ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.84256381
2	response to pheromone (GO:0019236)	4.63554556
3	DNA deamination (GO:0045006)	4.53448672
4	indole-containing compound catabolic process (GO:0042436)	4.48803806
5	indolalkylamine catabolic process (GO:0046218)	4.48803806
6	tryptophan catabolic process (GO:0006569)	4.48803806
7	kynurenine metabolic process (GO:0070189)	4.39579884
8	indolalkylamine metabolic process (GO:0006586)	3.98134251
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.92953469
10	tryptophan metabolic process (GO:0006568)	3.90197148
11	L-fucose catabolic process (GO:0042355)	3.85047402
12	fucose catabolic process (GO:0019317)	3.85047402
13	L-fucose metabolic process (GO:0042354)	3.85047402
14	adaptation of signaling pathway (GO:0023058)	3.68660489
15	positive regulation of defense response to virus by host (GO:0002230)	3.62876435
16	cellular ketone body metabolic process (GO:0046950)	3.61437834
17	negative regulation of telomere maintenance (GO:0032205)	3.57915848
18	cellular biogenic amine catabolic process (GO:0042402)	3.49222112
19	amine catabolic process (GO:0009310)	3.49222112
20	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.47726488
21	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.44526997
22	multicellular organism reproduction (GO:0032504)	3.41921374
23	preassembly of GPI anchor in ER membrane (GO:0016254)	3.36628563
24	regulation of cilium movement (GO:0003352)	3.35544080
25	positive regulation of prostaglandin secretion (GO:0032308)	3.35240704
26	detection of light stimulus involved in visual perception (GO:0050908)	3.32978565
27	detection of light stimulus involved in sensory perception (GO:0050962)	3.32978565
28	epithelial cilium movement (GO:0003351)	3.24544388
29	protein polyglutamylation (GO:0018095)	3.24433168
30	cytidine metabolic process (GO:0046087)	3.22687769
31	cytidine catabolic process (GO:0006216)	3.22687769
32	cytidine deamination (GO:0009972)	3.22687769
33	positive regulation of fatty acid transport (GO:2000193)	3.21088085
34	ketone body metabolic process (GO:1902224)	3.18135524
35	water-soluble vitamin biosynthetic process (GO:0042364)	3.17935154
36	regulation of memory T cell differentiation (GO:0043380)	3.07277600
37	negative regulation of mast cell activation (GO:0033004)	3.01279260
38	sperm motility (GO:0030317)	2.95946293
39	axoneme assembly (GO:0035082)	2.95812212
40	piRNA metabolic process (GO:0034587)	2.94348095
41	respiratory chain complex IV assembly (GO:0008535)	2.92328156
42	protein complex biogenesis (GO:0070271)	2.91789379
43	negative regulation of systemic arterial blood pressure (GO:0003085)	2.90875588
44	regulation of microtubule-based movement (GO:0060632)	2.87678784
45	protein localization to cilium (GO:0061512)	2.85929156
46	indole-containing compound metabolic process (GO:0042430)	2.84525984
47	platelet dense granule organization (GO:0060155)	2.83844283
48	positive regulation of icosanoid secretion (GO:0032305)	2.83078298
49	GPI anchor metabolic process (GO:0006505)	2.78483674
50	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.78421892
51	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.77114700
52	NADH dehydrogenase complex assembly (GO:0010257)	2.77114700
53	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.77114700
54	S-adenosylmethionine metabolic process (GO:0046500)	2.75140852
55	aromatic amino acid family catabolic process (GO:0009074)	2.67936625
56	photoreceptor cell maintenance (GO:0045494)	2.66845912
57	cilium movement (GO:0003341)	2.66383684
58	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.66306995
59	sulfation (GO:0051923)	2.65286112
60	positive regulation of heat generation (GO:0031652)	2.62935255
61	mannosylation (GO:0097502)	2.61721848
62	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.60940101
63	cytochrome complex assembly (GO:0017004)	2.60333996
64	regulation of prostaglandin secretion (GO:0032306)	2.59468874
65	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.57939222
66	benzene-containing compound metabolic process (GO:0042537)	2.57734275
67	polyol catabolic process (GO:0046174)	2.57068344
68	adenosine metabolic process (GO:0046085)	2.55951876
69	mitochondrial respiratory chain complex assembly (GO:0033108)	2.55746416
70	cellular response to ATP (GO:0071318)	2.55605339
71	ubiquinone biosynthetic process (GO:0006744)	2.53128853
72	positive regulation of T-helper 1 type immune response (GO:0002827)	2.52934201
73	cornea development in camera-type eye (GO:0061303)	2.52606583
74	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.50931514
75	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.50850813
76	GPI anchor biosynthetic process (GO:0006506)	2.50233040
77	regulation of action potential (GO:0098900)	2.48832677
78	gamma-aminobutyric acid transport (GO:0015812)	2.48138821
79	neural tube formation (GO:0001841)	2.47398634
80	reflex (GO:0060004)	2.45255051
81	synaptic transmission, cholinergic (GO:0007271)	2.42597070
82	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.41902481
83	ubiquinone metabolic process (GO:0006743)	2.41032199
84	cilium morphogenesis (GO:0060271)	2.40373778
85	rhodopsin mediated signaling pathway (GO:0016056)	2.38976055
86	regulation of hippo signaling (GO:0035330)	2.36443720
87	mitotic cell cycle arrest (GO:0071850)	2.36114266
88	C-terminal protein lipidation (GO:0006501)	2.35214935
89	acrosome reaction (GO:0007340)	2.34111107
90	DNA methylation involved in gamete generation (GO:0043046)	2.32574841
91	cilium or flagellum-dependent cell motility (GO:0001539)	2.32412090
92	protein-cofactor linkage (GO:0018065)	2.32300745
93	establishment of protein localization to Golgi (GO:0072600)	2.31669704
94	dopamine transport (GO:0015872)	2.30786423
95	regulation of heat generation (GO:0031650)	2.29717703
96	NAD biosynthetic process (GO:0009435)	2.28768853
97	cellular response to exogenous dsRNA (GO:0071360)	2.28202811
98	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.28010930
99	auditory receptor cell stereocilium organization (GO:0060088)	2.28004152
100	C-terminal protein amino acid modification (GO:0018410)	2.27476278

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.90200765
2	VDR_22108803_ChIP-Seq_LS180_Human	3.65292460
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.93457739
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.36648606
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.36137982
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.29487036
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.27773411
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.18202448
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.15781905
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.08298652
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.01337363
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.99164177
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.98327005
14	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.97853916
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.88704280
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.87653260
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.85738255
18	P300_19829295_ChIP-Seq_ESCs_Human	1.84807866
19	EWS_26573619_Chip-Seq_HEK293_Human	1.77454824
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.76995839
21	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.70945360
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.70858790
23	FUS_26573619_Chip-Seq_HEK293_Human	1.66614460
24	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.63345812
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.63345812
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.62437590
27	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.57668530
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.52919677
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.49169453
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.48649563
31	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.44616705
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.44552984
33	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.42974111
34	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.42974111
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.41819396
36	AR_25329375_ChIP-Seq_VCAP_Human	1.41470320
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.40504948
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38639883
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.38533740
40	NANOG_19829295_ChIP-Seq_ESCs_Human	1.38533740
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38317370
42	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.37059545
43	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.36189174
44	STAT3_23295773_ChIP-Seq_U87_Human	1.33270121
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33001282
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32712363
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.32498744
48	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.32188208
49	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.31025813
50	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29539662
51	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.29539662
52	SMAD4_21799915_ChIP-Seq_A2780_Human	1.29280420
53	TCF4_23295773_ChIP-Seq_U87_Human	1.26927589
54	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.26902998
55	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.26382101
56	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.25625526
57	AR_20517297_ChIP-Seq_VCAP_Human	1.25571466
58	HOXB7_26014856_ChIP-Seq_BT474_Human	1.24910245
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.23120881
60	NCOR_22424771_ChIP-Seq_293T_Human	1.22230951
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20828122
62	REST_21632747_ChIP-Seq_MESCs_Mouse	1.20565285
63	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.20431318
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19899521
65	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.19774274
66	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.18625982
67	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17717870
68	MYC_19829295_ChIP-Seq_ESCs_Human	1.17544093
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16368001
70	AR_21572438_ChIP-Seq_LNCaP_Human	1.16281784
71	GATA3_26560356_Chip-Seq_TH2_Human	1.15915997
72	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.15263048
73	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13685795
74	ERA_21632823_ChIP-Seq_H3396_Human	1.13646198
75	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12235098
76	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.11589739
77	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11428888
78	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.11212754
79	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.10790707
80	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.10631694
81	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10194922
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.07676617
83	MYC_18940864_ChIP-ChIP_HL60_Human	1.06471086
84	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05599865
85	CDX2_22108803_ChIP-Seq_LS180_Human	1.05140577
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04815579
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04226130
88	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03882026
89	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02618295
90	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.02212402
91	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.02075703
92	TAF2_19829295_ChIP-Seq_ESCs_Human	1.01613384
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00944573
94	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00850145
95	OCT4_20526341_ChIP-Seq_ESCs_Human	0.99711153
96	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.96706743
97	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.96416600
98	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.95305414
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95111958
100	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.94729474

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.41260653
2	MP0002837_dystrophic_cardiac_calcinosis	2.87678990
3	MP0004043_abnormal_pH_regulation	2.78272849
4	MP0003011_delayed_dark_adaptation	2.71434653
5	MP0003646_muscle_fatigue	2.70853517
6	MP0002138_abnormal_hepatobiliary_system	2.65534708
7	MP0001968_abnormal_touch/_nociception	2.38348411
8	MP0005551_abnormal_eye_electrophysiolog	2.36614111
9	MP0005167_abnormal_blood-brain_barrier	2.31241690
10	MP0008877_abnormal_DNA_methylation	2.18879849
11	MP0002736_abnormal_nociception_after	2.14124729
12	MP0002876_abnormal_thyroid_physiology	2.12063741
13	MP0005410_abnormal_fertilization	2.11176370
14	MP0006072_abnormal_retinal_apoptosis	2.10435795
15	MP0001501_abnormal_sleep_pattern	2.00464106
16	MP0005671_abnormal_response_to	1.90793572
17	MP0005645_abnormal_hypothalamus_physiol	1.81990110
18	MP0009046_muscle_twitch	1.79161729
19	MP0005253_abnormal_eye_physiology	1.78794737
20	MP0005646_abnormal_pituitary_gland	1.77647633
21	MP0000569_abnormal_digit_pigmentation	1.72383132
22	MP0009745_abnormal_behavioral_response	1.63406186
23	MP0004142_abnormal_muscle_tone	1.62896760
24	MP0005084_abnormal_gallbladder_morpholo	1.57986029
25	MP0010386_abnormal_urinary_bladder	1.56982926
26	MP0002148_abnormal_hypersensitivity_rea	1.56118438
27	MP0005379_endocrine/exocrine_gland_phen	1.53594178
28	MP0002272_abnormal_nervous_system	1.53374773
29	MP0008872_abnormal_physiological_respon	1.50483492
30	MP0009785_altered_susceptibility_to	1.49201352
31	MP0002163_abnormal_gland_morphology	1.46069121
32	MP0009764_decreased_sensitivity_to	1.44194729
33	MP0002638_abnormal_pupillary_reflex	1.41937340
34	MP0004885_abnormal_endolymph	1.40020089
35	MP0008875_abnormal_xenobiotic_pharmacok	1.39459320
36	MP0002735_abnormal_chemical_nociception	1.37698546
37	MP0000372_irregular_coat_pigmentation	1.36885672
38	MP0004742_abnormal_vestibular_system	1.35680989
39	MP0001485_abnormal_pinna_reflex	1.34844314
40	MP0001986_abnormal_taste_sensitivity	1.33803735
41	MP0005310_abnormal_salivary_gland	1.32233976
42	MP0001970_abnormal_pain_threshold	1.31942187
43	MP0001835_abnormal_antigen_presentation	1.31834911
44	MP0002234_abnormal_pharynx_morphology	1.30831266
45	MP0002733_abnormal_thermal_nociception	1.30693316
46	MP0002102_abnormal_ear_morphology	1.29284568
47	MP0004147_increased_porphyrin_level	1.25673340
48	MP0006292_abnormal_olfactory_placode	1.25125055
49	MP0001764_abnormal_homeostasis	1.21917746
50	MP0002693_abnormal_pancreas_physiology	1.19795089
51	MP0000230_abnormal_systemic_arterial	1.19075376
52	MP0001873_stomach_inflammation	1.13688563
53	MP0003787_abnormal_imprinting	1.12690981
54	MP0002653_abnormal_ependyma_morphology	1.10973902
55	MP0001984_abnormal_olfaction	1.10070297
56	MP0005389_reproductive_system_phenotype	1.08809497
57	MP0002064_seizures	1.05593387
58	MP0003718_maternal_effect	1.05502009
59	MP0003724_increased_susceptibility_to	1.05239899
60	MP0000427_abnormal_hair_cycle	1.04951827
61	MP0004924_abnormal_behavior	1.02804092
62	MP0005386_behavior/neurological_phenoty	1.02804092
63	MP0003136_yellow_coat_color	1.02475597
64	MP0001919_abnormal_reproductive_system	1.02319175
65	MP0000685_abnormal_immune_system	1.01682907
66	MP0002572_abnormal_emotion/affect_behav	1.01238663
67	MP0006276_abnormal_autonomic_nervous	1.01163137
68	MP0002557_abnormal_social/conspecific_i	1.00576983
69	MP0001486_abnormal_startle_reflex	0.99295726
70	MP0005085_abnormal_gallbladder_physiolo	0.99158387
71	MP0000538_abnormal_urinary_bladder	0.98870488
72	MP0001905_abnormal_dopamine_level	0.95104299
73	MP0005332_abnormal_amino_acid	0.94612920
74	MP0000631_abnormal_neuroendocrine_gland	0.94525568
75	MP0005387_immune_system_phenotype	0.94420473
76	MP0001790_abnormal_immune_system	0.94420473
77	MP0005636_abnormal_mineral_homeostasis	0.93864349
78	MP0001765_abnormal_ion_homeostasis	0.93545727
79	MP0002067_abnormal_sensory_capabilities	0.90573312
80	MP0003880_abnormal_central_pattern	0.90075323
81	MP0003698_abnormal_male_reproductive	0.88703896
82	MP0002909_abnormal_adrenal_gland	0.87698238
83	MP0005647_abnormal_sex_gland	0.87352086
84	MP0004019_abnormal_vitamin_homeostasis	0.86443760
85	MP0001800_abnormal_humoral_immune	0.85278034
86	MP0005365_abnormal_bile_salt	0.84839318
87	MP0002229_neurodegeneration	0.84723581
88	MP0005448_abnormal_energy_balance	0.83993461
89	MP0002277_abnormal_respiratory_mucosa	0.81552550
90	MP0002160_abnormal_reproductive_system	0.81155823
91	MP0001756_abnormal_urination	0.80940892
92	MP0004145_abnormal_muscle_electrophysio	0.80572311
93	MP0006082_CNS_inflammation	0.80032470
94	MP0008775_abnormal_heart_ventricle	0.79742814
95	MP0002928_abnormal_bile_duct	0.79038734
96	MP0005195_abnormal_posterior_eye	0.78849225
97	MP0001664_abnormal_digestion	0.78775433
98	MP0003137_abnormal_impulse_conducting	0.77587738
99	MP0001502_abnormal_circadian_rhythm	0.77087534
100	MP0004133_heterotaxia	0.76496681

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.55105564
2	Congenital stationary night blindness (HP:0007642)	4.14887402
3	Abnormality of midbrain morphology (HP:0002418)	4.00489816
4	Molar tooth sign on MRI (HP:0002419)	4.00489816
5	Pancreatic fibrosis (HP:0100732)	3.92091517
6	Nephronophthisis (HP:0000090)	3.79589076
7	True hermaphroditism (HP:0010459)	3.63025582
8	Abnormality of the renal cortex (HP:0011035)	3.48198509
9	Abnormality of the renal medulla (HP:0100957)	3.32899770
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.21817494
11	Type II lissencephaly (HP:0007260)	3.16492763
12	Tubular atrophy (HP:0000092)	3.14373922
13	Attenuation of retinal blood vessels (HP:0007843)	3.09145313
14	Chronic hepatic failure (HP:0100626)	3.01389559
15	Polydipsia (HP:0001959)	2.99275722
16	Abnormal drinking behavior (HP:0030082)	2.99275722
17	Abolished electroretinogram (ERG) (HP:0000550)	2.82951377
18	Medial flaring of the eyebrow (HP:0010747)	2.79074255
19	Hyperventilation (HP:0002883)	2.74439976
20	Cystic liver disease (HP:0006706)	2.65988831
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.55997621
22	Abnormality of alanine metabolism (HP:0010916)	2.52068900
23	Hyperalaninemia (HP:0003348)	2.52068900
24	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.52068900
25	Absent/shortened dynein arms (HP:0200106)	2.49216488
26	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.49216488
27	Progressive cerebellar ataxia (HP:0002073)	2.48638556
28	Pendular nystagmus (HP:0012043)	2.47698836
29	Polyuria (HP:0000103)	2.39699072
30	Gaze-evoked nystagmus (HP:0000640)	2.38527016
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.33449018
32	Decreased central vision (HP:0007663)	2.33147217
33	Amelogenesis imperfecta (HP:0000705)	2.32736862
34	Stomatitis (HP:0010280)	2.30420769
35	Decreased circulating renin level (HP:0003351)	2.28460048
36	Renal cortical cysts (HP:0000803)	2.25911665
37	Genetic anticipation (HP:0003743)	2.25847239
38	Large for gestational age (HP:0001520)	2.24116130
39	3-Methylglutaconic aciduria (HP:0003535)	2.22772636
40	Inability to walk (HP:0002540)	2.20819342
41	Congenital hepatic fibrosis (HP:0002612)	2.16838161
42	Sclerocornea (HP:0000647)	2.16791249
43	Abnormality of macular pigmentation (HP:0008002)	2.16576715
44	Mitochondrial inheritance (HP:0001427)	2.16556848
45	Clumsiness (HP:0002312)	2.14705496
46	Gait imbalance (HP:0002141)	2.12984183
47	Keratoconus (HP:0000563)	2.12622938
48	Increased corneal curvature (HP:0100692)	2.12622938
49	Severe visual impairment (HP:0001141)	2.11340563
50	Aplasia/hypoplasia of the uterus (HP:0008684)	2.11209391
51	Hypothermia (HP:0002045)	2.10958737
52	Increased CSF lactate (HP:0002490)	2.10924238
53	Abnormal respiratory motile cilium morphology (HP:0005938)	2.07989100
54	Abnormal respiratory epithelium morphology (HP:0012253)	2.07989100
55	Cerebellar dysplasia (HP:0007033)	2.06871724
56	Bony spicule pigmentary retinopathy (HP:0007737)	2.05165743
57	Congenital primary aphakia (HP:0007707)	2.04959605
58	Ketosis (HP:0001946)	2.04031416
59	Congenital, generalized hypertrichosis (HP:0004540)	2.00783035
60	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.00731492
61	Broad-based gait (HP:0002136)	2.00475732
62	Optic disc pallor (HP:0000543)	1.95471915
63	Generalized aminoaciduria (HP:0002909)	1.94681721
64	Hepatocellular necrosis (HP:0001404)	1.94643117
65	Lissencephaly (HP:0001339)	1.94182196
66	Acute necrotizing encephalopathy (HP:0006965)	1.93875237
67	Abnormal urine output (HP:0012590)	1.93647234
68	Ketoacidosis (HP:0001993)	1.93619403
69	Male pseudohermaphroditism (HP:0000037)	1.92893685
70	Azoospermia (HP:0000027)	1.90813630
71	Furrowed tongue (HP:0000221)	1.88674612
72	Hepatic necrosis (HP:0002605)	1.88544786
73	Fair hair (HP:0002286)	1.88433696
74	Bile duct proliferation (HP:0001408)	1.88263069
75	Abnormal biliary tract physiology (HP:0012439)	1.88263069
76	Abnormality of renal excretion (HP:0011036)	1.85993864
77	Nephrogenic diabetes insipidus (HP:0009806)	1.85847199
78	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.84954853
79	Abnormal ciliary motility (HP:0012262)	1.84715926
80	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.84324302
81	Hypoplasia of the fovea (HP:0007750)	1.84324302
82	Retinal dysplasia (HP:0007973)	1.84142027
83	Anencephaly (HP:0002323)	1.83038490
84	Tubulointerstitial fibrosis (HP:0005576)	1.77141046
85	Optic neuritis (HP:0100653)	1.77087068
86	Retrobulbar optic neuritis (HP:0100654)	1.77087068
87	Constricted visual fields (HP:0001133)	1.76174884
88	Concave nail (HP:0001598)	1.76039942
89	Rib fusion (HP:0000902)	1.75480821
90	Thyroiditis (HP:0100646)	1.75337151
91	Lipid accumulation in hepatocytes (HP:0006561)	1.74849188
92	Progressive inability to walk (HP:0002505)	1.74640741
93	Generalized hypopigmentation of hair (HP:0011358)	1.73379126
94	IgG deficiency (HP:0004315)	1.71908589
95	Postaxial foot polydactyly (HP:0001830)	1.71292407
96	Congenital sensorineural hearing impairment (HP:0008527)	1.71279554
97	Pachygyria (HP:0001302)	1.70712664
98	Progressive macrocephaly (HP:0004481)	1.70666476
99	Agitation (HP:0000713)	1.70468573
100	Absent speech (HP:0001344)	1.69593887

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.54179251
2	ADRBK2	3.53915355
3	BMPR1B	3.30959340
4	MAP4K2	3.20471429
5	WNK4	2.90688057
6	GRK1	2.88434319
7	TLK1	2.68690581
8	PINK1	2.65379247
9	TXK	2.63001674
10	TAOK3	2.43831386
11	ZAK	2.32145486
12	ACVR1B	2.24121104
13	NUAK1	2.15246350
14	DAPK2	1.98728340
15	STK39	1.96638040
16	WNK3	1.96323528
17	INSRR	1.93883138
18	MAPK13	1.62147512
19	OXSR1	1.59717766
20	GRK7	1.48806693
21	AKT3	1.44049283
22	BCKDK	1.29336517
23	CASK	1.28049762
24	MAP3K4	1.27195273
25	MAP2K6	1.21501300
26	TGFBR1	1.15057645
27	IKBKB	1.13412071
28	MAPKAPK3	1.13091519
29	STK38L	1.06715852
30	EPHA3	1.04670000
31	TNK2	0.97714110
32	PIK3CA	0.97328724
33	MAP2K7	0.96398231
34	VRK1	0.93872214
35	CAMKK2	0.93099885
36	PHKG1	0.87705614
37	PHKG2	0.87705614
38	MAPK15	0.86336001
39	PRKCE	0.86123775
40	ADRBK1	0.81667673
41	PAK3	0.80051640
42	CSNK1A1L	0.76975274
43	PRKD3	0.72092849
44	CSNK1G2	0.71825531
45	CSNK1G3	0.71030095
46	PRKCG	0.70610238
47	PLK2	0.69791706
48	DYRK2	0.69366278
49	PRKCQ	0.69166546
50	KIT	0.67770361
51	CHUK	0.67672591
52	TEC	0.66195059
53	CAMK1D	0.66113781
54	MST4	0.64685422
55	ERBB3	0.64089713
56	PLK4	0.64012885
57	MKNK2	0.59723844
58	IRAK1	0.57555487
59	FER	0.57520490
60	MARK3	0.57044329
61	CDK8	0.56895719
62	MAPKAPK5	0.55581875
63	CSNK1G1	0.55121269
64	STK3	0.53907502
65	PKN1	0.53757667
66	TAF1	0.52099630
67	EIF2AK3	0.51757548
68	CAMK1	0.50669876
69	RPS6KA5	0.50461318
70	NTRK3	0.48527287
71	TRIM28	0.48005374
72	CAMK1G	0.47404442
73	ITK	0.47253633
74	CSNK1A1	0.46985874
75	BCR	0.46599626
76	SYK	0.45093129
77	TNIK	0.44486511
78	PRKACA	0.43617499
79	MYLK	0.43088787
80	SIK2	0.42944325
81	TRPM7	0.40870628
82	MATK	0.39203690
83	STK24	0.39095030
84	IKBKE	0.38516349
85	TIE1	0.36372596
86	PRKAA2	0.35568123
87	PTK2B	0.35066721
88	WNK1	0.34522539
89	OBSCN	0.34456871
90	KDR	0.34048280
91	STK11	0.33436813
92	PRKCI	0.32737097
93	PRKCA	0.31914543
94	CAMK2A	0.31749390
95	NLK	0.31369101
96	TESK2	0.31328934
97	PRKAA1	0.31129005
98	NME1	0.30923657
99	LYN	0.29972402
100	VRK2	0.29219304

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.78039846
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.67145621
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.50506884
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.46661060
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.25932703
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.23162098
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.16553070
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.10443154
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.06565430
10	Butanoate metabolism_Homo sapiens_hsa00650	1.98873743
11	Asthma_Homo sapiens_hsa05310	1.98604448
12	Tryptophan metabolism_Homo sapiens_hsa00380	1.90747082
13	Graft-versus-host disease_Homo sapiens_hsa05332	1.81334747
14	Allograft rejection_Homo sapiens_hsa05330	1.80900934
15	Type I diabetes mellitus_Homo sapiens_hsa04940	1.80282984
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.68641223
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.64044090
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.61807919
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.57473118
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.55105194
21	Rheumatoid arthritis_Homo sapiens_hsa05323	1.53291567
22	Parkinsons disease_Homo sapiens_hsa05012	1.50287066
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.49229346
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.48350901
25	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.48258212
26	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.40388693
27	Protein export_Homo sapiens_hsa03060	1.40321826
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.39814185
29	Caffeine metabolism_Homo sapiens_hsa00232	1.37846787
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.36762816
31	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.33043236
32	Olfactory transduction_Homo sapiens_hsa04740	1.31929416
33	RNA polymerase_Homo sapiens_hsa03020	1.31757718
34	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.31500661
35	Peroxisome_Homo sapiens_hsa04146	1.31184106
36	Mineral absorption_Homo sapiens_hsa04978	1.28093820
37	Nicotine addiction_Homo sapiens_hsa05033	1.27661514
38	Basal transcription factors_Homo sapiens_hsa03022	1.20068261
39	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.17138789
40	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.15697735
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.15320198
42	Primary immunodeficiency_Homo sapiens_hsa05340	1.14221122
43	ABC transporters_Homo sapiens_hsa02010	1.07467368
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.07351375
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.06435049
46	Chemical carcinogenesis_Homo sapiens_hsa05204	1.05897675
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.04870015
48	Cardiac muscle contraction_Homo sapiens_hsa04260	1.03577650
49	Propanoate metabolism_Homo sapiens_hsa00640	1.01134262
50	Alzheimers disease_Homo sapiens_hsa05010	1.00297393
51	Homologous recombination_Homo sapiens_hsa03440	0.97653496
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.97147141
53	Morphine addiction_Homo sapiens_hsa05032	0.94403006
54	Proteasome_Homo sapiens_hsa03050	0.92405083
55	Retinol metabolism_Homo sapiens_hsa00830	0.92307239
56	Taste transduction_Homo sapiens_hsa04742	0.91190403
57	Huntingtons disease_Homo sapiens_hsa05016	0.90397571
58	Sulfur metabolism_Homo sapiens_hsa00920	0.89685151
59	Fanconi anemia pathway_Homo sapiens_hsa03460	0.87607726
60	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.86003450
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84860114
62	Antigen processing and presentation_Homo sapiens_hsa04612	0.84039356
63	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.82861405
64	Regulation of autophagy_Homo sapiens_hsa04140	0.80424178
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.78202055
66	Salivary secretion_Homo sapiens_hsa04970	0.75059009
67	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.72776952
68	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.71525566
69	Insulin secretion_Homo sapiens_hsa04911	0.71411752
70	GABAergic synapse_Homo sapiens_hsa04727	0.70281138
71	RNA degradation_Homo sapiens_hsa03018	0.70043726
72	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.69633364
73	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.68703839
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.68698479
75	Serotonergic synapse_Homo sapiens_hsa04726	0.67289607
76	One carbon pool by folate_Homo sapiens_hsa00670	0.67054876
77	Circadian entrainment_Homo sapiens_hsa04713	0.63803095
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62961014
79	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.60682409
80	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.60102239
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.58847122
82	Fatty acid degradation_Homo sapiens_hsa00071	0.57645879
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.56258142
84	Purine metabolism_Homo sapiens_hsa00230	0.56190861
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.55775477
86	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.54235636
87	African trypanosomiasis_Homo sapiens_hsa05143	0.51591348
88	Metabolic pathways_Homo sapiens_hsa01100	0.51242944
89	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.49271529
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.46951860
91	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.45897933
92	Histidine metabolism_Homo sapiens_hsa00340	0.45035362
93	Steroid biosynthesis_Homo sapiens_hsa00100	0.44686978
94	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.44278325
95	Glutamatergic synapse_Homo sapiens_hsa04724	0.43501485
96	Calcium signaling pathway_Homo sapiens_hsa04020	0.42692536
97	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.40878473
98	Sphingolipid metabolism_Homo sapiens_hsa00600	0.40686396
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39440047
100	Pyrimidine metabolism_Homo sapiens_hsa00240	0.38910406

HMGN2P46

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »