HMGN2P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.68747531
2folic acid-containing compound biosynthetic process (GO:0009396)5.34918469
3regulation of autophagic vacuole assembly (GO:2000785)4.98281987
4V(D)J recombination (GO:0033151)4.72367023
5purine nucleotide salvage (GO:0032261)4.64561839
6ribosome biogenesis (GO:0042254)4.48655374
7DNA strand elongation involved in DNA replication (GO:0006271)4.44978689
8maturation of SSU-rRNA (GO:0030490)4.41671478
9telomere maintenance via semi-conservative replication (GO:0032201)4.35424065
10regulation of G0 to G1 transition (GO:0070316)4.26226925
11rRNA modification (GO:0000154)4.25630464
12DNA strand elongation (GO:0022616)4.25175169
13ribonucleoprotein complex biogenesis (GO:0022613)4.13788284
14response to vitamin A (GO:0033189)4.11126266
15rRNA methylation (GO:0031167)4.08852529
16regulation of vacuole organization (GO:0044088)4.00601909
17cellular response to lithium ion (GO:0071285)3.99894099
18negative regulation of T cell apoptotic process (GO:0070233)3.92502815
19DNA replication initiation (GO:0006270)3.92276886
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.91612262
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.91612262
22galactose catabolic process (GO:0019388)3.76538789
23positive regulation of fatty acid oxidation (GO:0046321)3.76297290
24negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.68813177
25nucleotide salvage (GO:0043173)3.68120239
26telomere maintenance via recombination (GO:0000722)3.65426943
27L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.61815997
28negative regulation of macroautophagy (GO:0016242)3.58615942
29homocysteine metabolic process (GO:0050667)3.46744215
30negative regulation of organelle assembly (GO:1902116)3.41167467
31cellular response to epidermal growth factor stimulus (GO:0071364)3.34703004
32positive regulation by host of viral transcription (GO:0043923)3.33629149
33regulation of receptor binding (GO:1900120)3.32171750
34RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)3.30057448
35heterochromatin organization (GO:0070828)3.29182773
36mesonephros development (GO:0001823)3.28075658
37DNA ligation (GO:0006266)3.27345672
38ribosome assembly (GO:0042255)3.26022357
39cellular component biogenesis (GO:0044085)3.24922739
40mitotic recombination (GO:0006312)3.22820700
41intra-S DNA damage checkpoint (GO:0031573)3.22246706
42negative regulation of lymphocyte apoptotic process (GO:0070229)3.14965560
43telomere maintenance via telomere lengthening (GO:0010833)3.14587513
44modulation by host of symbiont transcription (GO:0052472)3.14069987
45modulation by host of viral transcription (GO:0043921)3.14069987
46DNA catabolic process, exonucleolytic (GO:0000738)3.13663656
47detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.13440470
48pseudouridine synthesis (GO:0001522)3.12565975
49peptidyl-arginine omega-N-methylation (GO:0035247)3.09759132
50AMP metabolic process (GO:0046033)3.09509093
51barbed-end actin filament capping (GO:0051016)3.08329859
52behavioral response to nicotine (GO:0035095)3.07836413
53tRNA modification (GO:0006400)3.07045715
54modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)3.05203333
55cellular response to zinc ion (GO:0071294)3.02283776
56pteridine-containing compound biosynthetic process (GO:0042559)3.00789561
57alternative mRNA splicing, via spliceosome (GO:0000380)2.99081466
58ribosomal small subunit assembly (GO:0000028)2.97758614
59negative regulation of striated muscle cell apoptotic process (GO:0010664)2.95764653
60regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.93863917
61DNA replication checkpoint (GO:0000076)2.93759061
62C21-steroid hormone biosynthetic process (GO:0006700)2.92801915
63rRNA transcription (GO:0009303)2.92516034
64negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.90906253
65regulation of oxidative phosphorylation (GO:0002082)2.90873280
66amino acid salvage (GO:0043102)2.88992806
67L-methionine salvage (GO:0071267)2.88992806
68L-methionine biosynthetic process (GO:0071265)2.88992806
69thyroid gland development (GO:0030878)2.88753859
70oligosaccharide biosynthetic process (GO:0009312)2.87417486
71DNA double-strand break processing (GO:0000729)2.84479218
72negative regulation of response to nutrient levels (GO:0032108)2.84357515
73negative regulation of response to extracellular stimulus (GO:0032105)2.84357515
74positive regulation of fatty acid metabolic process (GO:0045923)2.81766140
75inner mitochondrial membrane organization (GO:0007007)2.80669758
76sulfur amino acid biosynthetic process (GO:0000097)2.79085127
77rRNA processing (GO:0006364)2.76135422
78epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.75692597
79chromatin assembly (GO:0031497)2.75538355
80positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.75183845
81mRNA cleavage (GO:0006379)2.74781972
82microtubule nucleation (GO:0007020)2.73779908
83TOR signaling (GO:0031929)2.73694444
84negative regulation of cell size (GO:0045792)2.73691669
85coenzyme catabolic process (GO:0009109)2.72894136
86UTP biosynthetic process (GO:0006228)2.70408094
87otic vesicle formation (GO:0030916)2.68692638
88tetrahydrofolate metabolic process (GO:0046653)2.68088956
89rRNA metabolic process (GO:0016072)2.66383514
90folic acid metabolic process (GO:0046655)2.65019647
91IMP biosynthetic process (GO:0006188)2.64531459
92GTP biosynthetic process (GO:0006183)2.63954795
93chaperone-mediated protein transport (GO:0072321)2.62899522
94adenosine metabolic process (GO:0046085)2.62854000
95negative regulation of DNA-templated transcription, elongation (GO:0032785)2.61423712
96establishment of protein localization to mitochondrial membrane (GO:0090151)2.58983943
97sulfur amino acid catabolic process (GO:0000098)2.58318489
98folic acid-containing compound metabolic process (GO:0006760)2.57515135
99response to muscle activity (GO:0014850)2.56946621
100positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.56699308

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.44120744
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.20011217
3E2F7_22180533_ChIP-Seq_HELA_Human5.47924527
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.23978974
5CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.16781096
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.95653603
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84557916
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.70348156
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.53030436
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45938322
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.38061148
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.30324657
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10377548
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.08735281
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.03527746
16E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94419808
17CIITA_25753668_ChIP-Seq_RAJI_Human1.91616636
18XRN2_22483619_ChIP-Seq_HELA_Human1.89219795
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.87402360
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.85906081
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83984891
22VDR_21846776_ChIP-Seq_THP-1_Human1.79369004
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.77982472
24VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.70997681
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69447035
26MAF_26560356_Chip-Seq_TH2_Human1.67161366
27GABP_19822575_ChIP-Seq_HepG2_Human1.65948741
28FOXP3_21729870_ChIP-Seq_TREG_Human1.62721367
29MYC_22102868_ChIP-Seq_BL_Human1.62325445
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61949276
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61873509
32KDM5A_27292631_Chip-Seq_BREAST_Human1.57441728
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55783150
34DCP1A_22483619_ChIP-Seq_HELA_Human1.54255953
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.54238966
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53989911
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52443738
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51911163
39E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.50255369
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.48702105
41VDR_23849224_ChIP-Seq_CD4+_Human1.46094582
42ZNF263_19887448_ChIP-Seq_K562_Human1.46014602
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.43928893
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40943832
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37693259
46UTX_26944678_Chip-Seq_JUKART_Human1.36530683
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.31822052
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29892067
49WDR5_24793694_ChIP-Seq_LNCAP_Human1.29263243
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29257584
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28630248
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25125438
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24508687
54P68_20966046_ChIP-Seq_HELA_Human1.21885352
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.19437728
56SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17368557
57BCL6_27268052_Chip-Seq_Bcells_Human1.16745883
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16612646
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16233071
60E2F1_20622854_ChIP-Seq_HELA_Human1.15085849
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14246722
62CTCF_20526341_ChIP-Seq_ESCs_Human1.14081677
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12350242
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12219086
65RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.10202177
66BCOR_27268052_Chip-Seq_Bcells_Human1.10013673
67MYB_26560356_Chip-Seq_TH2_Human1.09764724
68MYB_26560356_Chip-Seq_TH1_Human1.07607991
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05408600
70TTF2_22483619_ChIP-Seq_HELA_Human1.03713281
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03489824
72SPI1_20517297_ChIP-Seq_HL60_Human1.02432519
73LXR_22292898_ChIP-Seq_THP-1_Human1.02071825
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01005953
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00612974
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00590898
77PHF8_20622854_ChIP-Seq_HELA_Human1.00392683
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00355598
79TP53_22127205_ChIP-Seq_IMR90_Human0.99508921
80CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99319166
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98972108
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98860681
83ELF1_20517297_ChIP-Seq_JURKAT_Human0.98407049
84P300_27268052_Chip-Seq_Bcells_Human0.97415263
85SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93714150
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93069215
87AR_21909140_ChIP-Seq_LNCAP_Human0.92849075
88E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90953875
89CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89005111
90NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88972643
91SMC4_20622854_ChIP-Seq_HELA_Human0.88218441
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87836419
93CTCF_21964334_Chip-Seq_Bcells_Human0.87005418
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86417423
95TET1_21451524_ChIP-Seq_MESCs_Mouse0.86093613
96ERA_21632823_ChIP-Seq_H3396_Human0.84801231
97FOXP1_21924763_ChIP-Seq_HESCs_Human0.84749652
98TDRD3_21172665_ChIP-Seq_MCF-7_Human0.84275584
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83869094
100TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83351189

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.61683043
2MP0010094_abnormal_chromosome_stability3.35265665
3MP0003693_abnormal_embryo_hatching3.10891247
4MP0003315_abnormal_perineum_morphology3.03714897
5MP0002160_abnormal_reproductive_system2.97822659
6MP0000465_gastrointestinal_hemorrhage2.80419204
7MP0008004_abnormal_stomach_pH2.74585573
8MP0002132_abnormal_respiratory_system2.61017519
9MP0000678_abnormal_parathyroid_gland2.52564274
10MP0009697_abnormal_copulation2.48438918
11MP0008058_abnormal_DNA_repair2.46198034
12MP0003763_abnormal_thymus_physiology2.41175886
13MP0005646_abnormal_pituitary_gland2.40581910
14MP0003111_abnormal_nucleus_morphology2.37805669
15MP0001661_extended_life_span2.33083104
16MP0000749_muscle_degeneration2.07014906
17MP0004185_abnormal_adipocyte_glucose2.00371842
18MP0008995_early_reproductive_senescence1.99478300
19MP0002837_dystrophic_cardiac_calcinosis1.97837492
20MP0005451_abnormal_body_composition1.82287582
21MP0005360_urolithiasis1.76080781
22MP0003705_abnormal_hypodermis_morpholog1.74912714
23MP0003077_abnormal_cell_cycle1.74898071
24MP0002127_abnormal_cardiovascular_syste1.73841594
25MP0009840_abnormal_foam_cell1.70675039
26MP0002396_abnormal_hematopoietic_system1.68821481
27MP0004381_abnormal_hair_follicle1.58161986
28MP0002249_abnormal_larynx_morphology1.57205629
29MP0000703_abnormal_thymus_morphology1.56483312
30MP0003786_premature_aging1.47462542
31MP0001764_abnormal_homeostasis1.46284032
32MP0004957_abnormal_blastocyst_morpholog1.45772397
33MP0001849_ear_inflammation1.45332327
34MP0008932_abnormal_embryonic_tissue1.42936402
35MP0009250_abnormal_appendicular_skeleto1.38727740
36MP0008007_abnormal_cellular_replicative1.36232266
37MP0005410_abnormal_fertilization1.33752444
38MP0000681_abnormal_thyroid_gland1.29307035
39MP0000747_muscle_weakness1.27942972
40MP0001879_abnormal_lymphatic_vessel1.22501919
41MP0005389_reproductive_system_phenotype1.22297729
42MP0010368_abnormal_lymphatic_system1.18237944
43MP0000537_abnormal_urethra_morphology1.17919202
44MP0009278_abnormal_bone_marrow1.16632709
45MP0005330_cardiomyopathy1.15308856
46MP0000049_abnormal_middle_ear1.13079646
47MP0006036_abnormal_mitochondrial_physio1.10747129
48MP0002722_abnormal_immune_system1.09964357
49MP0000013_abnormal_adipose_tissue1.08059546
50MP0001270_distended_abdomen1.07276959
51MP0003385_abnormal_body_wall1.06840786
52MP0004233_abnormal_muscle_weight1.05623691
53MP0002108_abnormal_muscle_morphology1.04515468
54MP0002269_muscular_atrophy1.03556973
55MP0003183_abnormal_peptide_metabolism1.01950207
56MP0001853_heart_inflammation1.01690804
57MP0002398_abnormal_bone_marrow0.98762923
58MP0001666_abnormal_nutrient_absorption0.98635982
59MP0006035_abnormal_mitochondrial_morpho0.97962971
60MP0000759_abnormal_skeletal_muscle0.96790664
61MP0004084_abnormal_cardiac_muscle0.94600493
62MP0002019_abnormal_tumor_incidence0.94002672
63MP0001944_abnormal_pancreas_morphology0.89846084
64MP0009333_abnormal_splenocyte_physiolog0.88642432
65MP0002877_abnormal_melanocyte_morpholog0.85957101
66MP0005671_abnormal_response_to0.85445989
67MP0000516_abnormal_urinary_system0.84001171
68MP0005367_renal/urinary_system_phenotyp0.84001171
69MP0004087_abnormal_muscle_fiber0.83592326
70MP0004036_abnormal_muscle_relaxation0.81913929
71MP0000627_abnormal_mammary_gland0.81733454
72MP0000762_abnormal_tongue_morphology0.80706008
73MP0000490_abnormal_crypts_of0.80553964
74MP0001929_abnormal_gametogenesis0.78398081
75MP0008057_abnormal_DNA_replication0.78362407
76MP0004134_abnormal_chest_morphology0.76532508
77MP0002736_abnormal_nociception_after0.75748545
78MP0000733_abnormal_muscle_development0.75186022
79MP0003646_muscle_fatigue0.71596783
80MP0002210_abnormal_sex_determination0.71462713
81MP0005503_abnormal_tendon_morphology0.70143085
82MP0001145_abnormal_male_reproductive0.70056000
83MP0008789_abnormal_olfactory_epithelium0.68263543
84MP0005394_taste/olfaction_phenotype0.67552849
85MP0005499_abnormal_olfactory_system0.67552849
86MP0001664_abnormal_digestion0.67235200
87MP0002095_abnormal_skin_pigmentation0.64719671
88MP0001730_embryonic_growth_arrest0.63828733
89MP0005376_homeostasis/metabolism_phenot0.63788694
90MP0000350_abnormal_cell_proliferation0.63538837
91MP0003718_maternal_effect0.61888793
92MP0002429_abnormal_blood_cell0.60335898
93MP0000477_abnormal_intestine_morphology0.59586239
94MP0000716_abnormal_immune_system0.59411894
95MP0000653_abnormal_sex_gland0.58851068
96MP0000689_abnormal_spleen_morphology0.58128692
97MP0001800_abnormal_humoral_immune0.56624526
98MP0003936_abnormal_reproductive_system0.56613191
99MP0005670_abnormal_white_adipose0.56176340
100MP0005266_abnormal_metabolism0.55693799

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the columella (HP:0009929)6.23361122
2Aplastic anemia (HP:0001915)4.16362412
3Granulocytopenia (HP:0001913)3.81481526
4Reduced antithrombin III activity (HP:0001976)3.77650490
5Severe combined immunodeficiency (HP:0004430)3.56466560
6B lymphocytopenia (HP:0010976)3.47979441
7Chromsome breakage (HP:0040012)3.39811024
8Abnormality of DNA repair (HP:0003254)3.36406734
9Centrally nucleated skeletal muscle fibers (HP:0003687)3.35582488
10Thoracic kyphosis (HP:0002942)3.33908297
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.24126547
12Self-mutilation (HP:0000742)3.23536423
13Abnormality of the fetal cardiovascular system (HP:0010948)3.19887019
14Abnormal umbilical cord blood vessels (HP:0011403)3.19887019
15Single umbilical artery (HP:0001195)3.19887019
16Eosinophilia (HP:0001880)3.19546198
17Abnormality of B cell number (HP:0010975)3.11258507
18Abnormality of the renal collecting system (HP:0004742)3.08039611
19Aplasia/Hypoplasia of the sacrum (HP:0008517)3.06375195
20Myopathic facies (HP:0002058)3.05123680
21Duplicated collecting system (HP:0000081)3.05017670
22Reticulocytopenia (HP:0001896)3.02238814
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.00664059
24Decreased activity of mitochondrial respiratory chain (HP:0008972)3.00664059
25Thyroiditis (HP:0100646)2.98287318
26Progressive muscle weakness (HP:0003323)2.90370466
27Congenital sensorineural hearing impairment (HP:0008527)2.88273772
28Abnormality of eosinophils (HP:0001879)2.87003484
29Combined immunodeficiency (HP:0005387)2.86249353
30High anterior hairline (HP:0009890)2.85053171
31Abnormal number of erythroid precursors (HP:0012131)2.83180295
32Birth length less than 3rd percentile (HP:0003561)2.81293391
33Aplasia cutis congenita (HP:0001057)2.79677955
34Premature ovarian failure (HP:0008209)2.75873446
35Abnormality of pyrimidine metabolism (HP:0004353)2.73129400
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.71040027
37Absent thumb (HP:0009777)2.69342277
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68465556
39Abnormality of alanine metabolism (HP:0010916)2.68465556
40Hyperalaninemia (HP:0003348)2.68465556
41Squamous cell carcinoma (HP:0002860)2.66592744
42Abnormality of cells of the erythroid lineage (HP:0012130)2.58558062
43Hypergonadotropic hypogonadism (HP:0000815)2.55117377
44Abnormality of the preputium (HP:0100587)2.52607956
45Abnormality of the ileum (HP:0001549)2.49485185
46Hypoplasia of the thymus (HP:0000778)2.48264799
47Carpal bone hypoplasia (HP:0001498)2.45995115
48Abnormality of subcutaneous fat tissue (HP:0001001)2.45772246
49Ureteral duplication (HP:0000073)2.45315033
50Abnormality of the carotid arteries (HP:0005344)2.43347048
51Meckel diverticulum (HP:0002245)2.42877747
52Decreased subcutaneous fat (HP:0001002)2.37905792
53Pancytopenia (HP:0001876)2.37539911
54Unsteady gait (HP:0002317)2.35151974
55Arteriovenous malformation (HP:0100026)2.34527981
56Abnormality of cochlea (HP:0000375)2.32601809
57Abnormality of the thoracic spine (HP:0100711)2.26356998
58Abnormality of the incisor (HP:0000676)2.25123114
59Bone marrow hypocellularity (HP:0005528)2.24711108
60Ileus (HP:0002595)2.22210609
61Abnormality of chromosome stability (HP:0003220)2.18743385
62Abnormality of the umbilical cord (HP:0010881)2.18092771
63Reduced subcutaneous adipose tissue (HP:0003758)2.17759053
64Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.13537650
65Abnormality of the shoulder girdle musculature (HP:0001435)2.13368522
66Difficulty climbing stairs (HP:0003551)2.11078018
67Pendular nystagmus (HP:0012043)2.08345641
68Ectopic kidney (HP:0000086)2.08025793
69Panhypogammaglobulinemia (HP:0003139)2.07319878
70Diaphragmatic weakness (HP:0009113)2.06450127
71Spinal rigidity (HP:0003306)2.05810152
72Distal lower limb amyotrophy (HP:0008944)2.05246539
73Agammaglobulinemia (HP:0004432)2.04768132
74Duplication of thumb phalanx (HP:0009942)2.03768413
75Colitis (HP:0002583)2.01344287
76Oral leukoplakia (HP:0002745)1.98056072
77Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89956068
78Scapular winging (HP:0003691)1.89307298
79Hypoproteinemia (HP:0003075)1.88094285
80Pigmentary retinal degeneration (HP:0001146)1.87665335
81Sensory axonal neuropathy (HP:0003390)1.86096830
82Pili torti (HP:0003777)1.85969660
83Preauricular skin tag (HP:0000384)1.84792855
84Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.83056614
85Homocystinuria (HP:0002156)1.82059298
86Abnormality of homocysteine metabolism (HP:0010919)1.82059298
87Weak cry (HP:0001612)1.81416551
88Entropion (HP:0000621)1.81242502
89Nasolacrimal duct obstruction (HP:0000579)1.79445081
90Constricted visual fields (HP:0001133)1.75485603
91Chronic sinusitis (HP:0011109)1.75156383
92High pitched voice (HP:0001620)1.74464282
93Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73768980
94Horseshoe kidney (HP:0000085)1.72309319
95Aplasia/Hypoplasia of the thymus (HP:0010515)1.71517486
96Autoimmune hemolytic anemia (HP:0001890)1.71210064
97Poikiloderma (HP:0001029)1.70831474
98Fatigue (HP:0012378)1.68860056
99Increased muscle lipid content (HP:0009058)1.67288705
100Abnormality of the intrinsic pathway (HP:0010989)1.67098510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.98073756
2PINK14.25539902
3NEK23.63022839
4MARK33.18582250
5NME22.80285113
6MST1R2.60569709
7CDK122.52040108
8KDR2.15687214
9OBSCN2.10272205
10CCNB12.07901007
11NME12.02560007
12VRK21.92765102
13ARAF1.90089541
14MAP4K11.87882517
15MAP2K71.84681911
16ZAK1.83109989
17CDC71.82355722
18WNK41.81104205
19CSNK1A1L1.70442615
20CSNK1G31.64107346
21TESK21.63535015
22EEF2K1.56981249
23MAP3K131.54135679
24VRK11.43259733
25MAP2K31.40711585
26RPS6KB21.39877138
27MAP3K101.39022680
28NLK1.35987483
29BCKDK1.31284965
30AURKA1.30490418
31CSNK1G11.29947369
32AURKB1.14799419
33SGK4941.14285039
34SGK2231.14285039
35MYLK1.05039709
36PRKCQ1.00947763
37CDK70.99419605
38CDK90.97545653
39CSNK1G20.96997325
40TRIB30.96314410
41BMPR1B0.94582951
42CDK80.94035922
43MAP3K10.93945927
44ATR0.93649298
45RPS6KA50.92038357
46PIM20.91313643
47MTOR0.90312873
48MELK0.89925450
49CDK30.89649095
50RPS6KB10.89154289
51CLK10.85587730
52MAP3K30.85292793
53ICK0.82207203
54ZAP700.81593758
55LATS10.76590744
56PHKG20.76232134
57PHKG10.76232134
58BTK0.73016282
59TXK0.72369502
60PLK10.71976207
61FGR0.70174726
62SGK20.67052518
63BUB10.64912939
64RPS6KA40.61229740
65SRPK10.60455573
66ATM0.55946356
67MST40.55116811
68SYK0.54818826
69CSNK1A10.53732694
70PAK10.52732605
71ILK0.52487633
72PIK3CG0.52097870
73MAPK120.52068068
74DYRK30.52008060
75AKT20.50382167
76MAPKAPK30.50108078
77WNK10.49326730
78JAK30.46186144
79MOS0.45618794
80CDK40.45178661
81MAP3K110.44762138
82SCYL20.43710734
83CHEK10.43170022
84PRKD20.42810902
85CHEK20.42016756
86CSNK2A20.42003472
87ERN10.41795596
88MAP3K90.41582432
89FES0.40458001
90PBK0.39986219
91ACVR1B0.39967920
92CSNK2A10.39761910
93MAPK110.37521689
94PRKG20.37279191
95CDK20.35633687
96GRK60.34591692
97MAP3K80.34204725
98CDK10.33948762
99PDGFRB0.33753715
100DAPK30.31820947

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.11274143
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.82018823
3One carbon pool by folate_Homo sapiens_hsa006703.29296610
4Systemic lupus erythematosus_Homo sapiens_hsa053223.04746530
5Olfactory transduction_Homo sapiens_hsa047402.87184757
6Sulfur relay system_Homo sapiens_hsa041222.82591848
7Primary immunodeficiency_Homo sapiens_hsa053402.80370797
8RNA polymerase_Homo sapiens_hsa030202.79284849
9Ribosome_Homo sapiens_hsa030102.78713073
10Fanconi anemia pathway_Homo sapiens_hsa034602.52813395
11Pyrimidine metabolism_Homo sapiens_hsa002402.41581176
12Nucleotide excision repair_Homo sapiens_hsa034202.39247149
13Homologous recombination_Homo sapiens_hsa034402.34066876
14Alcoholism_Homo sapiens_hsa050342.29124030
15Base excision repair_Homo sapiens_hsa034102.24669120
16Mismatch repair_Homo sapiens_hsa034302.23803368
17Spliceosome_Homo sapiens_hsa030402.03687727
18Proteasome_Homo sapiens_hsa030501.80518247
19Purine metabolism_Homo sapiens_hsa002301.64794651
20RNA transport_Homo sapiens_hsa030131.63834107
21Basal transcription factors_Homo sapiens_hsa030221.57847299
22Phototransduction_Homo sapiens_hsa047441.54599086
23Arginine biosynthesis_Homo sapiens_hsa002201.51803727
24Oocyte meiosis_Homo sapiens_hsa041141.36002524
25Non-homologous end-joining_Homo sapiens_hsa034501.34695345
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29217034
27Pyruvate metabolism_Homo sapiens_hsa006201.27547297
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25056045
29RNA degradation_Homo sapiens_hsa030181.20442688
30Oxidative phosphorylation_Homo sapiens_hsa001901.20297078
31mRNA surveillance pathway_Homo sapiens_hsa030151.18481748
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13341580
33Parkinsons disease_Homo sapiens_hsa050121.11981730
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03973899
35Alzheimers disease_Homo sapiens_hsa050101.00658991
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97420242
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96156802
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90852154
39Maturity onset diabetes of the young_Homo sapiens_hsa049500.88536917
40Galactose metabolism_Homo sapiens_hsa000520.86775868
41Salivary secretion_Homo sapiens_hsa049700.85417540
42Huntingtons disease_Homo sapiens_hsa050160.83887137
43Vitamin digestion and absorption_Homo sapiens_hsa049770.83669257
44Nitrogen metabolism_Homo sapiens_hsa009100.82809780
45T cell receptor signaling pathway_Homo sapiens_hsa046600.80328992
46Folate biosynthesis_Homo sapiens_hsa007900.75387567
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74894331
48Thyroid cancer_Homo sapiens_hsa052160.74663794
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73927024
50Biosynthesis of amino acids_Homo sapiens_hsa012300.71772833
51Cell cycle_Homo sapiens_hsa041100.71692084
52Viral carcinogenesis_Homo sapiens_hsa052030.69221670
53Carbon metabolism_Homo sapiens_hsa012000.68657459
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.66169299
55Apoptosis_Homo sapiens_hsa042100.65764733
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63094404
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.61727989
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59720483
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59403241
60Chemical carcinogenesis_Homo sapiens_hsa052040.57717175
61Glucagon signaling pathway_Homo sapiens_hsa049220.55764264
62Fructose and mannose metabolism_Homo sapiens_hsa000510.55747272
63Melanoma_Homo sapiens_hsa052180.53198186
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52576836
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50838071
66Butanoate metabolism_Homo sapiens_hsa006500.49921475
67Endometrial cancer_Homo sapiens_hsa052130.49313958
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.45198579
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44698369
70Metabolic pathways_Homo sapiens_hsa011000.43450761
71Glutathione metabolism_Homo sapiens_hsa004800.39352066
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38765941
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37464653
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37188678
75B cell receptor signaling pathway_Homo sapiens_hsa046620.35499743
76Prostate cancer_Homo sapiens_hsa052150.34492061
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33832516
78Renin secretion_Homo sapiens_hsa049240.32543641
79Hematopoietic cell lineage_Homo sapiens_hsa046400.32506260
80Hedgehog signaling pathway_Homo sapiens_hsa043400.30919314
81AMPK signaling pathway_Homo sapiens_hsa041520.29850992
82Oxytocin signaling pathway_Homo sapiens_hsa049210.29703933
83Peroxisome_Homo sapiens_hsa041460.29587288
84Epstein-Barr virus infection_Homo sapiens_hsa051690.29408426
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28966083
86Sulfur metabolism_Homo sapiens_hsa009200.27907843
87Calcium signaling pathway_Homo sapiens_hsa040200.27372116
88Pentose phosphate pathway_Homo sapiens_hsa000300.27072198
89Insulin resistance_Homo sapiens_hsa049310.26634595
90Glioma_Homo sapiens_hsa052140.26314727
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26280009
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.26113226
93Non-small cell lung cancer_Homo sapiens_hsa052230.25448597
94Herpes simplex infection_Homo sapiens_hsa051680.24308133
95HTLV-I infection_Homo sapiens_hsa051660.23657739
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23531645
97Taste transduction_Homo sapiens_hsa047420.22704971
98Acute myeloid leukemia_Homo sapiens_hsa052210.22557056
99Regulation of autophagy_Homo sapiens_hsa041400.21728707
100Measles_Homo sapiens_hsa051620.21363354

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