HMGN2P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)9.07427429
2tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)9.07427429
3folic acid-containing compound biosynthetic process (GO:0009396)8.07895215
4homocysteine metabolic process (GO:0050667)7.66141075
5regulation of plasminogen activation (GO:0010755)7.55799780
6sulfur amino acid catabolic process (GO:0000098)6.18716829
7cysteine metabolic process (GO:0006534)5.94167623
8purine nucleotide salvage (GO:0032261)5.54974839
9alternative mRNA splicing, via spliceosome (GO:0000380)5.53024827
10microtubule nucleation (GO:0007020)5.51585760
11negative regulation of synaptic transmission, glutamatergic (GO:0051967)5.45348687
12epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.44768483
13adenosine metabolic process (GO:0046085)5.30623181
14white fat cell differentiation (GO:0050872)5.24238794
15pteridine-containing compound biosynthetic process (GO:0042559)5.04093443
16galactose catabolic process (GO:0019388)5.01895415
17negative regulation of DNA biosynthetic process (GO:2000279)4.84254754
18regulation of vitamin D biosynthetic process (GO:0060556)4.66926163
19rRNA methylation (GO:0031167)4.48316733
20sequestering of actin monomers (GO:0042989)4.46298565
21neurotransmitter catabolic process (GO:0042135)4.46200311
22CENP-A containing nucleosome assembly (GO:0034080)4.41870062
23IMP biosynthetic process (GO:0006188)4.37842570
24mitochondrial RNA metabolic process (GO:0000959)4.33065543
25rRNA modification (GO:0000154)4.32041307
26desmosome organization (GO:0002934)4.24346556
27neurofilament cytoskeleton organization (GO:0060052)4.19090177
28tetrahydrofolate metabolic process (GO:0046653)4.18900402
29galactose metabolic process (GO:0006012)4.09125099
30chromatin remodeling at centromere (GO:0031055)4.06795033
31histone H4-K12 acetylation (GO:0043983)4.04977855
32positive regulation of amino acid transport (GO:0051957)4.02511052
33behavioral response to pain (GO:0048266)3.99403704
34regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.93354279
35L-serine metabolic process (GO:0006563)3.89433663
36positive regulation of endothelial cell differentiation (GO:0045603)3.87024024
37DNA strand renaturation (GO:0000733)3.86636471
38folic acid-containing compound metabolic process (GO:0006760)3.84622537
39inner ear receptor cell development (GO:0060119)3.83471639
40DNA ligation (GO:0006266)3.80886649
41cartilage morphogenesis (GO:0060536)3.79593130
42cell migration involved in heart development (GO:0060973)3.77273491
43protein-chromophore linkage (GO:0018298)3.71980952
44negative regulation of catenin import into nucleus (GO:0035414)3.71234360
45tRNA modification (GO:0006400)3.70531964
46positive regulation of fatty acid oxidation (GO:0046321)3.64032181
47regulation of vitamin metabolic process (GO:0030656)3.63564819
48pseudouridine synthesis (GO:0001522)3.60027876
49DNA replication-independent nucleosome organization (GO:0034724)3.56377739
50DNA replication-independent nucleosome assembly (GO:0006336)3.56377739
51regulation of gonadotropin secretion (GO:0032276)3.55138895
52IMP metabolic process (GO:0046040)3.54848740
53positive regulation of synaptic transmission, GABAergic (GO:0032230)3.54783378
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.52195931
55mitochondrial respiratory chain complex I assembly (GO:0032981)3.52195931
56NADH dehydrogenase complex assembly (GO:0010257)3.52195931
57serine family amino acid biosynthetic process (GO:0009070)3.51236377
58ribosome biogenesis (GO:0042254)3.49261511
59sulfur amino acid biosynthetic process (GO:0000097)3.46455688
60negative regulation of Ras GTPase activity (GO:0034261)3.45558448
61regulation of tight junction assembly (GO:2000810)3.43292532
62negative regulation of keratinocyte proliferation (GO:0010839)3.41510224
63aldehyde catabolic process (GO:0046185)3.35357949
64aminoglycoside antibiotic metabolic process (GO:0030647)3.34776851
65protein complex biogenesis (GO:0070271)3.26488450
66histone exchange (GO:0043486)3.23435181
67intermediate filament organization (GO:0045109)3.23149879
68negative regulation of telomerase activity (GO:0051974)3.22573606
69cochlea development (GO:0090102)3.20959359
70behavioral defense response (GO:0002209)3.17563275
71behavioral fear response (GO:0001662)3.17563275
72regulation of sequestering of triglyceride (GO:0010889)3.16639272
73tRNA processing (GO:0008033)3.14593738
74acrosome assembly (GO:0001675)3.13269867
75DNA double-strand break processing (GO:0000729)3.10354351
76regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.08894115
77regulation of energy homeostasis (GO:2000505)3.08592608
78proteasome assembly (GO:0043248)3.06568827
79response to vitamin A (GO:0033189)3.05890823
80negative regulation of acute inflammatory response (GO:0002674)3.05084402
81mitochondrial respiratory chain complex assembly (GO:0033108)3.03552088
82protein-cofactor linkage (GO:0018065)3.02926769
83positive regulation of fatty acid metabolic process (GO:0045923)2.99992544
84response to BMP (GO:0071772)2.99716016
85cellular response to BMP stimulus (GO:0071773)2.99716016
86inner mitochondrial membrane organization (GO:0007007)2.98966684
87pteridine-containing compound metabolic process (GO:0042558)2.96141205
88muscle atrophy (GO:0014889)2.93701107
89anterograde axon cargo transport (GO:0008089)2.92226053
90nucleoside transmembrane transport (GO:1901642)2.92192146
91platelet dense granule organization (GO:0060155)2.90939715
92negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.89530999
93regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89456381
94negative regulation of cell cycle arrest (GO:0071157)2.89166963
95phosphatidylglycerol biosynthetic process (GO:0006655)2.89131532
96peptidyl-arginine omega-N-methylation (GO:0035247)2.87314156
97DNA strand elongation involved in DNA replication (GO:0006271)2.81990656
98nucleotide salvage (GO:0043173)2.80446830
99sulfur amino acid metabolic process (GO:0000096)2.78806370
100DNA strand elongation (GO:0022616)2.76281388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.34742601
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.09903536
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.39866336
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25431943
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.88626807
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.81769649
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57708888
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36840942
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29787202
10AR_21909140_ChIP-Seq_LNCAP_Human2.28736967
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26572088
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.25159616
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24064608
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.18583495
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15180116
16ZNF263_19887448_ChIP-Seq_K562_Human2.14792257
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse12.8929227
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.97846165
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90086811
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.84484935
21CIITA_25753668_ChIP-Seq_RAJI_Human1.73533876
22MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72252449
23E2F1_21310950_ChIP-Seq_MCF-7_Human1.70085603
24XRN2_22483619_ChIP-Seq_HELA_Human1.68388865
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68339222
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65708385
27FOXP3_21729870_ChIP-Seq_TREG_Human1.63753241
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61227091
29VDR_23849224_ChIP-Seq_CD4+_Human1.58525358
30GABP_19822575_ChIP-Seq_HepG2_Human1.53124471
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48466340
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40806474
33ELK1_19687146_ChIP-ChIP_HELA_Human1.38958392
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35033264
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29973121
36ERG_20517297_ChIP-Seq_VCAP_Human1.27294597
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.23533404
38VDR_22108803_ChIP-Seq_LS180_Human1.23344355
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.22570186
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22098990
41ZNF274_21170338_ChIP-Seq_K562_Hela1.21738811
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20930847
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20310086
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.16482684
45CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.16015047
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15846941
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14914082
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14512911
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12437422
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.11385676
51TTF2_22483619_ChIP-Seq_HELA_Human1.11074690
52KDM5A_27292631_Chip-Seq_BREAST_Human1.07337726
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06346975
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06008119
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05765965
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05530386
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04267978
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03629079
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.01378453
60BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99388664
61DCP1A_22483619_ChIP-Seq_HELA_Human0.97500865
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94994241
63EED_16625203_ChIP-ChIP_MESCs_Mouse0.94951409
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93362599
65FUS_26573619_Chip-Seq_HEK293_Human0.92965875
66SOX2_22085726_ChIP-Seq_NPCs_Mouse0.91973577
67LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91722161
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90925583
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89810909
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89549436
71CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87543715
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87069931
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83912441
74PADI4_21655091_ChIP-ChIP_MCF-7_Human0.82291490
75NCOR_22424771_ChIP-Seq_293T_Human0.81727173
76TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81660957
77IRF1_19129219_ChIP-ChIP_H3396_Human0.81463354
78SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.81145456
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.79275498
80STAT6_21828071_ChIP-Seq_BEAS2B_Human0.78768269
81OCT1_27270436_Chip-Seq_PROSTATE_Human0.78079374
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.77898260
83NELFA_20434984_ChIP-Seq_ESCs_Mouse0.77895829
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76697878
85ETS1_21867929_ChIP-Seq_TH2_Mouse0.76576619
86YY1_22570637_ChIP-Seq_MALME-3M_Human0.74803596
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.74516193
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.72704016
89MYC_18940864_ChIP-ChIP_HL60_Human0.72324568
90CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.71412760
91TP53_22573176_ChIP-Seq_HFKS_Human0.70253239
92KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.68357148
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68321433
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.66758513
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.65473264
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.65296889
97KLF4_18555785_ChIP-Seq_MESCs_Mouse0.64814260
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.64522663
99EWS_26573619_Chip-Seq_HEK293_Human0.64462429
100STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.63253266

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.54861382
2MP0005360_urolithiasis4.79305908
3MP0008995_early_reproductive_senescence4.60789910
4MP0002735_abnormal_chemical_nociception4.49717073
5MP0005646_abnormal_pituitary_gland4.34024329
6MP0003705_abnormal_hypodermis_morpholog4.13463427
7MP0000013_abnormal_adipose_tissue3.04922899
8MP0002736_abnormal_nociception_after2.98000786
9MP0003183_abnormal_peptide_metabolism2.96353373
10MP0002396_abnormal_hematopoietic_system2.75181435
11MP0001661_extended_life_span2.61614721
12MP0009780_abnormal_chondrocyte_physiolo2.58385126
13MP0003724_increased_susceptibility_to2.51210427
14MP0000537_abnormal_urethra_morphology2.41383180
15MP0004185_abnormal_adipocyte_glucose2.39104262
16MP0002938_white_spotting2.29618849
17MP0008057_abnormal_DNA_replication2.07748309
18MP0002138_abnormal_hepatobiliary_system1.91571532
19MP0005367_renal/urinary_system_phenotyp1.91416884
20MP0000516_abnormal_urinary_system1.91416884
21MP0001968_abnormal_touch/_nociception1.90282055
22MP0010094_abnormal_chromosome_stability1.89133730
23MP0004885_abnormal_endolymph1.85136507
24MP0005076_abnormal_cell_differentiation1.83859136
25MP0003786_premature_aging1.71357440
26MP0003806_abnormal_nucleotide_metabolis1.64829736
27MP0002638_abnormal_pupillary_reflex1.60547867
28MP0001764_abnormal_homeostasis1.60182204
29MP0000534_abnormal_ureter_morphology1.57694130
30MP0004233_abnormal_muscle_weight1.55093295
31MP0000566_synostosis1.53897381
32MP0010386_abnormal_urinary_bladder1.51796052
33MP0002095_abnormal_skin_pigmentation1.49880452
34MP0005075_abnormal_melanosome_morpholog1.47203621
35MP0001756_abnormal_urination1.44214525
36MP0004381_abnormal_hair_follicle1.42506210
37MP0008058_abnormal_DNA_repair1.41558261
38MP0004147_increased_porphyrin_level1.39992075
39MP0009697_abnormal_copulation1.38971345
40MP0003942_abnormal_urinary_system1.23169086
41MP0000003_abnormal_adipose_tissue1.21940510
42MP0002282_abnormal_trachea_morphology1.19415529
43MP0000647_abnormal_sebaceous_gland1.16791717
44MP0002160_abnormal_reproductive_system1.10333391
45MP0003718_maternal_effect1.08605708
46MP0008872_abnormal_physiological_respon1.05985909
47MP0006072_abnormal_retinal_apoptosis1.03907790
48MP0005595_abnormal_vascular_smooth1.03727674
49MP0005332_abnormal_amino_acid1.02442257
50MP0001944_abnormal_pancreas_morphology1.00871067
51MP0003111_abnormal_nucleus_morphology0.95296817
52MP0004130_abnormal_muscle_cell0.91340669
53MP0001919_abnormal_reproductive_system0.90893704
54MP0002184_abnormal_innervation0.90475153
55MP0001145_abnormal_male_reproductive0.90409149
56MP0000631_abnormal_neuroendocrine_gland0.89718150
57MP0008873_increased_physiological_sensi0.88988180
58MP0004957_abnormal_blastocyst_morpholog0.86070317
59MP0005389_reproductive_system_phenotype0.85703612
60MP0000372_irregular_coat_pigmentation0.85034369
61MP0000371_diluted_coat_color0.85028276
62MP0000681_abnormal_thyroid_gland0.84161760
63MP0000653_abnormal_sex_gland0.82646510
64MP0005197_abnormal_uvea_morphology0.80244711
65MP0002210_abnormal_sex_determination0.78991288
66MP0001666_abnormal_nutrient_absorption0.78468155
67MP0001243_abnormal_dermal_layer0.76916534
68MP0008932_abnormal_embryonic_tissue0.76013074
69MP0009643_abnormal_urine_homeostasis0.74994762
70MP0009765_abnormal_xenobiotic_induced0.74255635
71MP0001346_abnormal_lacrimal_gland0.71830644
72MP0003186_abnormal_redox_activity0.71684794
73MP0010030_abnormal_orbit_morphology0.71471051
74MP0003936_abnormal_reproductive_system0.71084337
75MP0002075_abnormal_coat/hair_pigmentati0.70212475
76MP0004019_abnormal_vitamin_homeostasis0.68993237
77MP0004883_abnormal_blood_vessel0.68129582
78MP0009250_abnormal_appendicular_skeleto0.67687985
79MP0004043_abnormal_pH_regulation0.67436788
80MP0002139_abnormal_hepatobiliary_system0.65397415
81MP0001970_abnormal_pain_threshold0.65278151
82MP0005253_abnormal_eye_physiology0.64842849
83MP0005551_abnormal_eye_electrophysiolog0.63053616
84MP0000538_abnormal_urinary_bladder0.62660804
85MP0005220_abnormal_exocrine_pancreas0.61909589
86MP0000026_abnormal_inner_ear0.61842831
87MP0003077_abnormal_cell_cycle0.61626484
88MP0002734_abnormal_mechanical_nocicepti0.61014287
89MP0000678_abnormal_parathyroid_gland0.60805389
90MP0005376_homeostasis/metabolism_phenot0.60713053
91MP0001533_abnormal_skeleton_physiology0.58632109
92MP0008775_abnormal_heart_ventricle0.57658071
93MP0004133_heterotaxia0.57366101
94MP0009333_abnormal_splenocyte_physiolog0.53920222
95MP0009053_abnormal_anal_canal0.53601536
96MP0005666_abnormal_adipose_tissue0.53141076
97MP0003698_abnormal_male_reproductive0.53139658
98MP0003693_abnormal_embryo_hatching0.52426881
99MP0001929_abnormal_gametogenesis0.51491629
100MP0001119_abnormal_female_reproductive0.50317865

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)7.50404665
2Hyperalaninemia (HP:0003348)7.50404665
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)7.50404665
4Ulnar claw (HP:0001178)5.74033531
5Constricted visual fields (HP:0001133)5.12410440
6Birth length less than 3rd percentile (HP:0003561)5.05868566
7Esophageal varix (HP:0002040)4.50676660
8Abnormal umbilical cord blood vessels (HP:0011403)4.45723443
9Single umbilical artery (HP:0001195)4.45723443
10Abnormality of the fetal cardiovascular system (HP:0010948)4.45723443
11Congenital sensorineural hearing impairment (HP:0008527)4.40348804
12Spontaneous hematomas (HP:0007420)4.05095732
13White forelock (HP:0002211)3.98137369
14Segmental peripheral demyelination/remyelination (HP:0003481)3.86927859
15Patchy hypopigmentation of hair (HP:0011365)3.69783728
16Decreased electroretinogram (ERG) amplitude (HP:0000654)3.59876317
17Abnormality of the vasculature of the conjunctiva (HP:0008054)3.32881131
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.02360328
19Homocystinuria (HP:0002156)3.01830721
20Abnormality of homocysteine metabolism (HP:0010919)3.01830721
21Anorexia (HP:0002039)2.90171573
22Myocardial infarction (HP:0001658)2.87870246
23Reduced subcutaneous adipose tissue (HP:0003758)2.81757237
24Poor speech (HP:0002465)2.80957698
25Long clavicles (HP:0000890)2.80541942
26Oligomenorrhea (HP:0000876)2.77127812
27Abnormality of the umbilical cord (HP:0010881)2.75382861
28Abnormality of serum amino acid levels (HP:0003112)2.74748830
29Conjunctival telangiectasia (HP:0000524)2.74132145
30Heterochromia iridis (HP:0001100)2.66353851
31Action tremor (HP:0002345)2.64912394
32Stenosis of the external auditory canal (HP:0000402)2.59110094
33Panhypogammaglobulinemia (HP:0003139)2.56405094
343-Methylglutaconic aciduria (HP:0003535)2.53703524
35Conjugated hyperbilirubinemia (HP:0002908)2.52835242
36Arteriovenous malformation (HP:0100026)2.52564424
37Dyskinesia (HP:0100660)2.52046861
38Chronic otitis media (HP:0000389)2.51653749
39Toxemia of pregnancy (HP:0100603)2.49497499
40Steppage gait (HP:0003376)2.44390441
41Maternal diabetes (HP:0009800)2.43504747
42Attenuation of retinal blood vessels (HP:0007843)2.42440883
43Pigmentary retinal degeneration (HP:0001146)2.39717186
44Chromsome breakage (HP:0040012)2.39485748
45Abnormality of sulfur amino acid metabolism (HP:0004339)2.38028889
46Visceral angiomatosis (HP:0100761)2.37040375
47Biconcave vertebral bodies (HP:0004586)2.29438130
48Volvulus (HP:0002580)2.28869744
49Pulmonary embolism (HP:0002204)2.23222453
50Small hand (HP:0200055)2.22667227
51Pendular nystagmus (HP:0012043)2.21591696
52Hypopigmentation of the fundus (HP:0007894)2.21128222
53Chorioretinal atrophy (HP:0000533)2.19331003
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.19321772
55Abnormality of pyrimidine metabolism (HP:0004353)2.18743911
56Bone marrow hypocellularity (HP:0005528)2.17981489
57Generalized aminoaciduria (HP:0002909)2.17188893
58Fatigue (HP:0012378)2.16026051
59Insulin-resistant diabetes mellitus (HP:0000831)2.08622393
60Abnormality of the carotid arteries (HP:0005344)2.08129094
61Ectopic kidney (HP:0000086)2.05892928
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04313483
63Cavernous hemangioma (HP:0001048)2.03787815
64Abnormalities of placenta or umbilical cord (HP:0001194)2.02231710
65Cortical visual impairment (HP:0100704)2.01754950
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.00594965
67Hypomagnesemia (HP:0002917)2.00232561
68Focal segmental glomerulosclerosis (HP:0000097)1.99133129
69Hemangiomatosis (HP:0007461)1.98782946
70Hypoplastic left heart (HP:0004383)1.98642497
71Onion bulb formation (HP:0003383)1.96802573
72Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.93125580
73Increased serum lactate (HP:0002151)1.92316283
74Hyperglycinemia (HP:0002154)1.90019465
75Metabolic acidosis (HP:0001942)1.89432382
76Abnormality of the labia minora (HP:0012880)1.89328138
77Premature ovarian failure (HP:0008209)1.88203938
78Abnormal lung lobation (HP:0002101)1.86703478
79Symptomatic seizures (HP:0011145)1.83415699
80Anencephaly (HP:0002323)1.79980366
81Hammertoe (HP:0001765)1.79652454
82Premature graying of hair (HP:0002216)1.79638768
83Decreased subcutaneous fat (HP:0001002)1.79605931
84Peripheral demyelination (HP:0011096)1.79223499
85Hypoalphalipoproteinemia (HP:0003233)1.77414702
86Thrombophlebitis (HP:0004418)1.77208359
87Pustule (HP:0200039)1.77066256
88Type 2 muscle fiber atrophy (HP:0003554)1.74728104
89Hyperphosphaturia (HP:0003109)1.73127385
90Abnormality of placental membranes (HP:0011409)1.70695276
91Amniotic constriction ring (HP:0009775)1.70695276
92Abnormality of magnesium homeostasis (HP:0004921)1.69729966
93Nephrogenic diabetes insipidus (HP:0009806)1.68083033
94Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.68054918
95Meckel diverticulum (HP:0002245)1.66754956
96Abnormality of the preputium (HP:0100587)1.65741211
97Lactic acidosis (HP:0003128)1.65726717
98Duplicated collecting system (HP:0000081)1.64892951
99Abnormality of the renal collecting system (HP:0004742)1.63839668
100Reticulocytopenia (HP:0001896)1.62929150

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B6.31842057
2ACVR1B5.42078483
3CDK93.25171957
4TGFBR13.24270278
5MAP2K33.12864751
6CDK83.02237845
7MAP3K32.94135720
8VRK22.87297504
9RPS6KB22.01124269
10FGFR21.98531410
11SIK11.94725865
12BCKDK1.90422591
13CCNB11.86350019
14JAK31.83599148
15FGR1.81512824
16TRIB31.74099614
17KDR1.71933528
18KIT1.70584553
19BRSK21.70546503
20NTRK21.66230169
21CDK71.65013782
22TAF11.58238504
23SGK2231.54992872
24SGK4941.54992872
25SMG11.52092461
26AURKA1.44122145
27SGK21.42670074
28SIK21.42063109
29BRSK11.36906608
30MAP2K11.36676280
31DYRK21.25676696
32NEK61.17886832
33CDC71.15724971
34MST41.04147289
35FLT31.02796928
36EPHB21.00627921
37RPS6KB10.97617594
38PRKCH0.96802312
39VRK10.93915069
40PLK30.92186426
41TYRO30.86582023
42PAK40.86558463
43GRK10.85733530
44ATR0.85172091
45PRKCI0.80559602
46BUB10.75204098
47MARK10.74063969
48AURKB0.71413582
49SGK30.70309264
50PLK20.69788038
51CSF1R0.69176750
52ADRBK10.68607992
53PLK10.65097625
54STK110.62621281
55TESK20.62537793
56MTOR0.62390515
57MAP3K110.62384060
58CHEK20.59873680
59SCYL20.59858895
60ERBB40.56467938
61CSNK1A10.55627697
62EIF2AK20.54948775
63RPS6KA10.54681370
64ERBB30.54663371
65MET0.53875699
66CAMKK20.49129377
67EIF2AK30.48890689
68CAMK2A0.45694716
69PLK40.45409608
70PIK3CA0.38703550
71CSNK2A20.38247221
72INSRR0.38056169
73RPS6KL10.37973689
74RPS6KC10.37973689
75RPS6KA60.37444132
76ATM0.37188797
77SIK30.36555801
78PRKCG0.35793733
79PRKD30.34590621
80PRKCD0.34433219
81GSK3A0.34280166
82PDGFRB0.31464593
83NTRK30.31440832
84PIM20.30791585
85MINK10.30129340
86NUAK10.30004416
87PRKCA0.29212341
88CAMK10.28829991
89INSR0.28794960
90CDK20.28213583
91LRRK20.27967125
92PRKCE0.27481665
93WNK30.27063025
94CSNK2A10.26813483
95SYK0.26577735
96BCR0.26262710
97MAPK90.25122942
98ERBB20.23650760
99PRKCQ0.22712758
100CAMK2B0.21708395

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006705.24174946
2Proteasome_Homo sapiens_hsa030503.65511154
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.46256263
4DNA replication_Homo sapiens_hsa030303.17013210
5Sulfur relay system_Homo sapiens_hsa041222.56239125
6Oxidative phosphorylation_Homo sapiens_hsa001902.48298971
7Sulfur metabolism_Homo sapiens_hsa009202.29005464
8Base excision repair_Homo sapiens_hsa034102.17819850
9Arginine biosynthesis_Homo sapiens_hsa002202.15732492
10Non-homologous end-joining_Homo sapiens_hsa034502.05259961
11Cysteine and methionine metabolism_Homo sapiens_hsa002702.05151945
12Collecting duct acid secretion_Homo sapiens_hsa049661.96538127
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92396453
14RNA polymerase_Homo sapiens_hsa030201.88482264
15Fanconi anemia pathway_Homo sapiens_hsa034601.87021865
16Spliceosome_Homo sapiens_hsa030401.85482801
17Parkinsons disease_Homo sapiens_hsa050121.83327486
18Selenocompound metabolism_Homo sapiens_hsa004501.78114183
19Mismatch repair_Homo sapiens_hsa034301.70095497
20Huntingtons disease_Homo sapiens_hsa050161.67714699
21Nucleotide excision repair_Homo sapiens_hsa034201.66130272
22GABAergic synapse_Homo sapiens_hsa047271.65701183
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63980189
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63581631
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62172535
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.55727551
27Morphine addiction_Homo sapiens_hsa050321.47963013
28Basal transcription factors_Homo sapiens_hsa030221.47550868
29RNA degradation_Homo sapiens_hsa030181.45370923
30Biosynthesis of amino acids_Homo sapiens_hsa012301.41819552
31Homologous recombination_Homo sapiens_hsa034401.31380060
32Alzheimers disease_Homo sapiens_hsa050101.31266283
33mRNA surveillance pathway_Homo sapiens_hsa030151.27706036
34Nicotine addiction_Homo sapiens_hsa050331.27372551
35RNA transport_Homo sapiens_hsa030131.23016715
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22965608
37Pyrimidine metabolism_Homo sapiens_hsa002401.22730023
38Protein export_Homo sapiens_hsa030601.13323719
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11036346
40Other glycan degradation_Homo sapiens_hsa005111.08958465
41Glutamatergic synapse_Homo sapiens_hsa047241.04174650
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02823809
43Regulation of autophagy_Homo sapiens_hsa041401.02382805
44Cell cycle_Homo sapiens_hsa041101.01907841
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01615623
46Galactose metabolism_Homo sapiens_hsa000521.01578388
47Asthma_Homo sapiens_hsa053101.00928646
48Serotonergic synapse_Homo sapiens_hsa047260.93754359
49Taste transduction_Homo sapiens_hsa047420.87874945
50Phototransduction_Homo sapiens_hsa047440.83196412
51Vitamin digestion and absorption_Homo sapiens_hsa049770.78192925
52Purine metabolism_Homo sapiens_hsa002300.76056903
53Systemic lupus erythematosus_Homo sapiens_hsa053220.75763883
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74888038
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.72901967
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71481035
57Cholinergic synapse_Homo sapiens_hsa047250.71291890
58Graft-versus-host disease_Homo sapiens_hsa053320.70334063
59Alcoholism_Homo sapiens_hsa050340.67523940
60Rheumatoid arthritis_Homo sapiens_hsa053230.66037305
61Ribosome_Homo sapiens_hsa030100.63669239
62Primary immunodeficiency_Homo sapiens_hsa053400.62507197
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57641585
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57058723
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56432041
66Autoimmune thyroid disease_Homo sapiens_hsa053200.55647123
67Antigen processing and presentation_Homo sapiens_hsa046120.53654051
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52304480
69Circadian entrainment_Homo sapiens_hsa047130.51320925
70Arginine and proline metabolism_Homo sapiens_hsa003300.51145557
71Allograft rejection_Homo sapiens_hsa053300.50303786
72Dopaminergic synapse_Homo sapiens_hsa047280.49952745
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48826018
74Folate biosynthesis_Homo sapiens_hsa007900.47135975
75Metabolic pathways_Homo sapiens_hsa011000.46693647
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45519601
77Vibrio cholerae infection_Homo sapiens_hsa051100.45451875
78Type I diabetes mellitus_Homo sapiens_hsa049400.44048583
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43456374
80Carbon metabolism_Homo sapiens_hsa012000.43227624
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42926831
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41468409
83Thyroid cancer_Homo sapiens_hsa052160.40833159
84Cardiac muscle contraction_Homo sapiens_hsa042600.39961347
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39500400
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38458790
87Pyruvate metabolism_Homo sapiens_hsa006200.36995004
88Nitrogen metabolism_Homo sapiens_hsa009100.36673003
89HTLV-I infection_Homo sapiens_hsa051660.35131309
90Tryptophan metabolism_Homo sapiens_hsa003800.34421438
91Retinol metabolism_Homo sapiens_hsa008300.33649442
92AMPK signaling pathway_Homo sapiens_hsa041520.29305928
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28998541
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28187835
95Synaptic vesicle cycle_Homo sapiens_hsa047210.27183886
96Oocyte meiosis_Homo sapiens_hsa041140.25893430
97Epstein-Barr virus infection_Homo sapiens_hsa051690.25509636
98Olfactory transduction_Homo sapiens_hsa047400.24664368
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21477250
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.20875804

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