HMGN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)4.52385375
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.44341271
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.35152180
4sensory perception of smell (GO:0007608)4.35019616
5intraciliary transport (GO:0042073)4.31344494
6protein neddylation (GO:0045116)4.28698857
7axon ensheathment in central nervous system (GO:0032291)4.22808509
8central nervous system myelination (GO:0022010)4.22808509
9chromatin remodeling at centromere (GO:0031055)4.19981632
10protein localization to cilium (GO:0061512)4.19342194
11presynaptic membrane assembly (GO:0097105)4.15462356
12CENP-A containing nucleosome assembly (GO:0034080)4.12532795
13proteasome assembly (GO:0043248)3.94022164
14mitochondrial respiratory chain complex assembly (GO:0033108)3.86642166
15ER overload response (GO:0006983)3.81271588
16nonmotile primary cilium assembly (GO:0035058)3.80511049
17detection of calcium ion (GO:0005513)3.79125418
18neuron cell-cell adhesion (GO:0007158)3.78376639
19respiratory chain complex IV assembly (GO:0008535)3.77708207
20ribosomal small subunit assembly (GO:0000028)3.73898476
21signal peptide processing (GO:0006465)3.72956549
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.66429009
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.66429009
24NADH dehydrogenase complex assembly (GO:0010257)3.66429009
25presynaptic membrane organization (GO:0097090)3.65088846
26nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.59419855
27cytochrome complex assembly (GO:0017004)3.55800252
28neuron fate determination (GO:0048664)3.54943171
29axoneme assembly (GO:0035082)3.53233589
30exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.51641104
31cullin deneddylation (GO:0010388)3.51411261
32regulation of mitochondrial translation (GO:0070129)3.49614574
33cilium or flagellum-dependent cell motility (GO:0001539)3.45000177
34oxidative phosphorylation (GO:0006119)3.43989354
35histone exchange (GO:0043486)3.42872887
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.40119519
37establishment of integrated proviral latency (GO:0075713)3.38462088
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36444478
39DNA damage response, detection of DNA damage (GO:0042769)3.33681456
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.26098861
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.26098861
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.23707274
43termination of RNA polymerase III transcription (GO:0006386)3.23707274
44regulation of timing of cell differentiation (GO:0048505)3.22508780
45protein deneddylation (GO:0000338)3.20401684
46pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.19948102
47water-soluble vitamin biosynthetic process (GO:0042364)3.18525600
48aldehyde catabolic process (GO:0046185)3.17309604
49regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.17104307
50DNA double-strand break processing (GO:0000729)3.17033655
51postsynaptic membrane organization (GO:0001941)3.16757335
52DNA replication-independent nucleosome assembly (GO:0006336)3.16115608
53DNA replication-independent nucleosome organization (GO:0034724)3.16115608
54ATP biosynthetic process (GO:0006754)3.13993950
55photoreceptor cell differentiation (GO:0046530)3.13872424
56eye photoreceptor cell differentiation (GO:0001754)3.13872424
57cotranslational protein targeting to membrane (GO:0006613)3.13265822
58SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.13152002
59DNA ligation (GO:0006266)3.12733927
60endocrine pancreas development (GO:0031018)3.12693163
61sensory perception of chemical stimulus (GO:0007606)3.08622298
62synaptic vesicle exocytosis (GO:0016079)3.07790785
63response to redox state (GO:0051775)3.07790615
64purine nucleoside triphosphate biosynthetic process (GO:0009145)3.06712740
65translational termination (GO:0006415)3.04324965
66purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.04227790
67protein targeting to ER (GO:0045047)3.03963447
68spliceosomal snRNP assembly (GO:0000387)3.03957398
69viral transcription (GO:0019083)3.03282517
70regulation of mitotic spindle checkpoint (GO:1903504)3.03023668
71regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03023668
72positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01795160
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.97885168
74negative regulation of ligase activity (GO:0051352)2.97885168
75kinetochore assembly (GO:0051382)2.95262894
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93624670
77negative regulation of neurotransmitter transport (GO:0051589)2.92819558
78establishment of protein localization to endoplasmic reticulum (GO:0072599)2.92369333
79kinetochore organization (GO:0051383)2.89218015
80protein localization to endoplasmic reticulum (GO:0070972)2.88903063
81dopamine biosynthetic process (GO:0042416)2.88886048
82positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.86219816
83cilium morphogenesis (GO:0060271)2.85146599
84regulation of development, heterochronic (GO:0040034)2.84398317
85regulation of synaptic vesicle exocytosis (GO:2000300)2.83180024
86positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.81642939
87DNA replication checkpoint (GO:0000076)2.81326972
88inner mitochondrial membrane organization (GO:0007007)2.81292205
89translation (GO:0006412)2.79991500
90ribosomal large subunit biogenesis (GO:0042273)2.79898623
91platelet dense granule organization (GO:0060155)2.79017137
92COPI coating of Golgi vesicle (GO:0048205)2.78039887
93Golgi transport vesicle coating (GO:0048200)2.78039887
94magnesium ion transport (GO:0015693)2.77795265
95purine nucleobase biosynthetic process (GO:0009113)2.76781533
96maturation of SSU-rRNA (GO:0030490)2.76155893
97hydrogen ion transmembrane transport (GO:1902600)2.75929360
98protein polyglutamylation (GO:0018095)2.75268658
99regulation of helicase activity (GO:0051095)2.74722450
100cranial nerve development (GO:0021545)2.74659691
101neuronal action potential propagation (GO:0019227)2.74517620
102negative regulation of JUN kinase activity (GO:0043508)2.74197343
103ribonucleoside triphosphate biosynthetic process (GO:0009201)2.74095231
104histone mRNA metabolic process (GO:0008334)2.73720184
105base-excision repair, AP site formation (GO:0006285)2.73566801
106GTP biosynthetic process (GO:0006183)2.73301616
107negative regulation of neurotransmitter secretion (GO:0046929)2.73263133
108regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.72990168
109oligodendrocyte differentiation (GO:0048709)2.71575176
110nucleoside triphosphate biosynthetic process (GO:0009142)2.70723831
111intracellular protein transmembrane import (GO:0044743)2.70189572
112rRNA modification (GO:0000154)2.69406988
113regulation of cellular amino acid metabolic process (GO:0006521)2.68334002
114positive regulation of insulin secretion (GO:0032024)2.67200014
115centriole replication (GO:0007099)2.65270524
116negative regulation of DNA-dependent DNA replication (GO:2000104)2.63400764
117DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.62500847
118pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.62429258
119transmission of nerve impulse (GO:0019226)2.62206079
120cellular response to glucagon stimulus (GO:0071377)2.62065542
121protein targeting to mitochondrion (GO:0006626)2.61860695
122regulation of dopamine metabolic process (GO:0042053)2.61470805
123regulation of catecholamine metabolic process (GO:0042069)2.61470805
124protein maturation by protein folding (GO:0022417)2.61358825
125translational elongation (GO:0006414)2.61125309
126branched-chain amino acid catabolic process (GO:0009083)2.60897518
127peptide hormone processing (GO:0016486)2.60568389
128signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.60250387
129signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.60250387
130signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.60250387
131regulation of vesicle fusion (GO:0031338)2.60113663
132establishment of viral latency (GO:0019043)2.59601262
133mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.58984881
134glandular epithelial cell differentiation (GO:0002067)2.57991185
135regulation of amyloid precursor protein catabolic process (GO:1902991)2.56983896
136ATP synthesis coupled proton transport (GO:0015986)2.56797930
137energy coupled proton transport, down electrochemical gradient (GO:0015985)2.56797930
138positive regulation of oligodendrocyte differentiation (GO:0048714)2.56322885
139respiratory electron transport chain (GO:0022904)2.56013466
140electron transport chain (GO:0022900)2.55861310
141photoreceptor cell maintenance (GO:0045494)2.55664783
142startle response (GO:0001964)2.55403722
143establishment of melanosome localization (GO:0032401)2.53410546
144protein complex biogenesis (GO:0070271)2.53295560
145regulation of beta-amyloid formation (GO:1902003)2.52968905
146nucleotide transmembrane transport (GO:1901679)2.52520043
147regulation of cilium movement (GO:0003352)2.51660014
148neuron recognition (GO:0008038)2.51078460
149negative regulation of execution phase of apoptosis (GO:1900118)2.50664941
150positive regulation of amino acid transport (GO:0051957)2.50307244
151negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.50241217
152cilium assembly (GO:0042384)2.48981341
153insulin secretion (GO:0030073)2.48238863
154* regulation of insulin secretion (GO:0050796)2.46900985
155response to dietary excess (GO:0002021)2.46234724
156mannosylation (GO:0097502)2.45895990
157positive regulation of action potential (GO:0045760)2.44862633
158substantia nigra development (GO:0021762)2.44573403
159long-chain fatty acid biosynthetic process (GO:0042759)2.43372411
160regulation of type B pancreatic cell apoptotic process (GO:2000674)2.42878836
161establishment of pigment granule localization (GO:0051905)2.41552654
162fatty acid elongation (GO:0030497)2.40931769
163smoothened signaling pathway (GO:0007224)2.38411054
164chaperone-mediated protein transport (GO:0072321)2.38143647
165cilium organization (GO:0044782)2.37909508
166positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.37321346
167melanosome transport (GO:0032402)2.37054830
168protein localization to synapse (GO:0035418)2.36929823
169regulation of synaptic vesicle transport (GO:1902803)2.36333461
170axonemal dynein complex assembly (GO:0070286)2.35906060
171cellular response to leptin stimulus (GO:0044320)2.35554205
172negative regulation of synaptic transmission, GABAergic (GO:0032229)2.33125118
173gamma-aminobutyric acid signaling pathway (GO:0007214)2.32962986
174regulation of respiratory system process (GO:0044065)2.32514810
175myelination (GO:0042552)2.32497124
176regulation of secondary heart field cardioblast proliferation (GO:0003266)2.32395660
177regulation of cardioblast proliferation (GO:0003264)2.32395660
178mechanosensory behavior (GO:0007638)2.32177262
179catecholamine biosynthetic process (GO:0042423)2.32113843
180catechol-containing compound biosynthetic process (GO:0009713)2.32113843
181long-term synaptic potentiation (GO:0060291)2.31573071
182regulation of autophagic vacuole assembly (GO:2000785)2.31349009
183cilium movement (GO:0003341)2.31247145
184innervation (GO:0060384)2.29865597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.54129737
2EZH2_22144423_ChIP-Seq_EOC_Human4.32152748
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.14893394
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.93264468
5GBX2_23144817_ChIP-Seq_PC3_Human3.76096715
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.71872101
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.49696164
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.17427746
9* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.02169971
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.75481920
11ELK1_19687146_ChIP-ChIP_HELA_Human2.73263649
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.71456394
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.70047557
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65740764
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.64607395
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52948345
17* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52482359
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51962189
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.42786413
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.38976448
21* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38250498
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.32435178
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31998110
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.28621390
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24996170
26VDR_23849224_ChIP-Seq_CD4+_Human2.23574334
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21827509
28TAF15_26573619_Chip-Seq_HEK293_Human2.21422557
29* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20041336
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18429889
31* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15735485
32* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08609219
33POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05479011
34FOXP3_21729870_ChIP-Seq_TREG_Human2.00311568
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98763695
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98763695
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.97291426
38* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95641514
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.94000855
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89803390
41REST_21632747_ChIP-Seq_MESCs_Mouse1.88084748
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.87957979
43MYC_18940864_ChIP-ChIP_HL60_Human1.86856922
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83550383
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.83492129
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82939348
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.81137895
48E2F7_22180533_ChIP-Seq_HELA_Human1.80762098
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80053189
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.78874601
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.78802093
52FUS_26573619_Chip-Seq_HEK293_Human1.78350866
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78150658
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.77590348
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73288224
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.70466119
57* P300_19829295_ChIP-Seq_ESCs_Human1.68700263
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68312797
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68120740
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66291547
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63850229
62VDR_22108803_ChIP-Seq_LS180_Human1.63484199
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61556453
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59794793
65RNF2_27304074_Chip-Seq_NSC_Mouse1.58692470
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.57878505
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57829624
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57079923
69TTF2_22483619_ChIP-Seq_HELA_Human1.55381747
70* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55287741
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53491301
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.50238544
73SMAD4_21799915_ChIP-Seq_A2780_Human1.46018164
74DROSHA_22980978_ChIP-Seq_HELA_Human1.45800201
75* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42754147
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42393916
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.41970160
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41870720
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.41084208
80* REST_18959480_ChIP-ChIP_MESCs_Mouse1.39981192
81MYC_19079543_ChIP-ChIP_MESCs_Mouse1.39729862
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39127609
83DCP1A_22483619_ChIP-Seq_HELA_Human1.38655475
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38042332
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37651707
86SOX2_16153702_ChIP-ChIP_HESCs_Human1.37164636
87IGF1R_20145208_ChIP-Seq_DFB_Human1.37032805
88ER_23166858_ChIP-Seq_MCF-7_Human1.37009042
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36391437
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34373882
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31326824
92THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30378743
93GABP_19822575_ChIP-Seq_HepG2_Human1.29636315
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28368228
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27391928
96NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27207180
97NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26174238
98HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25542773
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25331741
100XRN2_22483619_ChIP-Seq_HELA_Human1.24211689
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21229944
102EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.20995613
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20234776
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.19713800
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19694650
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17175703
107STAT3_23295773_ChIP-Seq_U87_Human1.16230257
108YY1_21170310_ChIP-Seq_MESCs_Mouse1.15561713
109SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14530586
110MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13366067
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13357118
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12675711
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.12315473
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11816092
115IRF1_19129219_ChIP-ChIP_H3396_Human1.09063997
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09006397
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08685440
118* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06544496
119P53_22387025_ChIP-Seq_ESCs_Mouse1.06047389
120RARB_27405468_Chip-Seq_BRAIN_Mouse1.05867252
121AR_21909140_ChIP-Seq_LNCAP_Human1.05107976
122FOXM1_23109430_ChIP-Seq_U2OS_Human1.04846335
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04595002
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04223080
125RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03957001
126TP53_22573176_ChIP-Seq_HFKS_Human1.03382579
127RUNX2_22187159_ChIP-Seq_PCA_Human1.03315713
128CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03228840
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03196559
130* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02987500
131TCF4_23295773_ChIP-Seq_U87_Human1.01993700
132OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01791800
133E2F1_21310950_ChIP-Seq_MCF-7_Human1.01595270
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01245469
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01112343
136KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00851561
137HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00248389
138CMYC_18555785_Chip-Seq_ESCs_Mouse1.00208967
139SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99352922
140* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99212423
141RING1B_27294783_Chip-Seq_ESCs_Mouse0.98603451
142WT1_19549856_ChIP-ChIP_CCG9911_Human0.98599848
143EZH2_27294783_Chip-Seq_NPCs_Mouse0.98227297
144AR_25329375_ChIP-Seq_VCAP_Human0.97314540
145STAT3_18555785_Chip-Seq_ESCs_Mouse0.96904451
146MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96152995
147* SOX2_21211035_ChIP-Seq_LN229_Gbm0.95875140
148CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95524554
149NFE2_27457419_Chip-Seq_LIVER_Mouse0.95182738
150PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94285808
151E2F1_18555785_Chip-Seq_ESCs_Mouse0.93963398
152ZNF274_21170338_ChIP-Seq_K562_Hela0.93672054
153FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93544836
154FOXA1_25329375_ChIP-Seq_VCAP_Human0.93544836
155SOX2_18555785_Chip-Seq_ESCs_Mouse0.92804160
156KDM2B_26808549_Chip-Seq_REH_Human0.92421547
157JUN_21703547_ChIP-Seq_K562_Human0.92245045
158AR_20517297_ChIP-Seq_VCAP_Human0.92148727
159SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91918737
160POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91635710
161EWS_26573619_Chip-Seq_HEK293_Human0.91514247
162ELK1_22589737_ChIP-Seq_MCF10A_Human0.91156155
163CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90554786
164EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90464941
165NANOG_19829295_ChIP-Seq_ESCs_Human0.90297884
166SOX2_19829295_ChIP-Seq_ESCs_Human0.90297884
167ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89523564
168HTT_18923047_ChIP-ChIP_STHdh_Human0.89469402
169REST_19997604_ChIP-ChIP_NEURONS_Mouse0.89313852
170PRDM14_20953172_ChIP-Seq_ESCs_Human0.89295743
171PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84646380
172TCF4_22108803_ChIP-Seq_LS180_Human0.84442705

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction4.33081248
2MP0003880_abnormal_central_pattern3.11126988
3MP0005645_abnormal_hypothalamus_physiol2.94338336
4MP0010386_abnormal_urinary_bladder2.76060882
5MP0004270_analgesia2.60128877
6MP0008058_abnormal_DNA_repair2.56338759
7MP0000013_abnormal_adipose_tissue2.52907898
8MP0005379_endocrine/exocrine_gland_phen2.49799655
9MP0009379_abnormal_foot_pigmentation2.30248081
10MP0001293_anophthalmia2.24720240
11MP0005646_abnormal_pituitary_gland2.23669591
12MP0006072_abnormal_retinal_apoptosis2.21653430
13MP0010094_abnormal_chromosome_stability2.18624646
14MP0001529_abnormal_vocalization2.18420589
15MP0002272_abnormal_nervous_system2.09644661
16MP0002102_abnormal_ear_morphology2.08014498
17MP0003635_abnormal_synaptic_transmissio2.04821420
18MP0002734_abnormal_mechanical_nocicepti1.99019101
19MP0006292_abnormal_olfactory_placode1.96281272
20MP0008877_abnormal_DNA_methylation1.95768729
21MP0004957_abnormal_blastocyst_morpholog1.92878634
22MP0002909_abnormal_adrenal_gland1.92552882
23MP0008789_abnormal_olfactory_epithelium1.90791672
24MP0005423_abnormal_somatic_nervous1.90122714
25MP0001986_abnormal_taste_sensitivity1.89470525
26MP0004133_heterotaxia1.86557980
27MP0001905_abnormal_dopamine_level1.83837106
28MP0003693_abnormal_embryo_hatching1.83788134
29MP0005551_abnormal_eye_electrophysiolog1.83361878
30MP0001486_abnormal_startle_reflex1.81145101
31MP0001485_abnormal_pinna_reflex1.80176324
32MP0002638_abnormal_pupillary_reflex1.78211337
33MP0001502_abnormal_circadian_rhythm1.77989726
34MP0002064_seizures1.77095339
35MP0000631_abnormal_neuroendocrine_gland1.76653028
36MP0003186_abnormal_redox_activity1.75831972
37MP0004859_abnormal_synaptic_plasticity1.74936705
38MP0002572_abnormal_emotion/affect_behav1.74720952
39MP0002163_abnormal_gland_morphology1.73034856
40MP0003718_maternal_effect1.73004508
41MP0009745_abnormal_behavioral_response1.72189593
42MP0003011_delayed_dark_adaptation1.71525877
43MP0000778_abnormal_nervous_system1.70861934
44MP0006276_abnormal_autonomic_nervous1.70197791
45MP0002184_abnormal_innervation1.69928679
46MP0001188_hyperpigmentation1.67514287
47MP0005499_abnormal_olfactory_system1.67428190
48MP0005394_taste/olfaction_phenotype1.67428190
49MP0010030_abnormal_orbit_morphology1.67129637
50MP0003941_abnormal_skin_development1.65624619
51MP0003183_abnormal_peptide_metabolism1.64718692
52MP0002063_abnormal_learning/memory/cond1.64019282
53MP0004043_abnormal_pH_regulation1.63341272
54MP0002234_abnormal_pharynx_morphology1.61760406
55MP0003122_maternal_imprinting1.58751462
56MP0009780_abnormal_chondrocyte_physiolo1.58468644
57MP0002557_abnormal_social/conspecific_i1.57884954
58MP0008875_abnormal_xenobiotic_pharmacok1.56731704
59MP0006036_abnormal_mitochondrial_physio1.55375611
60MP0008995_early_reproductive_senescence1.54132006
61MP0008932_abnormal_embryonic_tissue1.51580720
62MP0005084_abnormal_gallbladder_morpholo1.49542673
63MP0002233_abnormal_nose_morphology1.46551269
64MP0002938_white_spotting1.44892176
65MP0000372_irregular_coat_pigmentation1.43931275
66MP0009046_muscle_twitch1.43428371
67MP0004885_abnormal_endolymph1.43393946
68MP0002693_abnormal_pancreas_physiology1.42868401
69MP0005171_absent_coat_pigmentation1.42150965
70MP0001944_abnormal_pancreas_morphology1.42131621
71MP0004742_abnormal_vestibular_system1.41736591
72MP0003937_abnormal_limbs/digits/tail_de1.41678457
73MP0003111_abnormal_nucleus_morphology1.41135508
74MP0005253_abnormal_eye_physiology1.41071698
75MP0002067_abnormal_sensory_capabilities1.40737617
76MP0003077_abnormal_cell_cycle1.40627226
77MP0002837_dystrophic_cardiac_calcinosis1.38899753
78MP0003806_abnormal_nucleotide_metabolis1.38307363
79MP0001968_abnormal_touch/_nociception1.38015142
80MP0002653_abnormal_ependyma_morphology1.37344636
81MP0003136_yellow_coat_color1.36260911
82MP0002877_abnormal_melanocyte_morpholog1.35778058
83MP0003567_abnormal_fetal_cardiomyocyte1.35218174
84MP0003634_abnormal_glial_cell1.34992721
85MP0003121_genomic_imprinting1.32322537
86MP0002733_abnormal_thermal_nociception1.31234962
87MP0000678_abnormal_parathyroid_gland1.31167034
88MP0003786_premature_aging1.29891728
89MP0002882_abnormal_neuron_morphology1.28130858
90MP0001970_abnormal_pain_threshold1.27775649
91MP0000955_abnormal_spinal_cord1.27595654
92MP0009697_abnormal_copulation1.25413658
93MP0001501_abnormal_sleep_pattern1.22236727
94MP0002876_abnormal_thyroid_physiology1.21503438
95MP0005248_abnormal_Harderian_gland1.20587623
96MP0006035_abnormal_mitochondrial_morpho1.20257862
97MP0000920_abnormal_myelination1.20196772
98MP0002282_abnormal_trachea_morphology1.19434365
99MP0005391_vision/eye_phenotype1.18389307
100MP0003938_abnormal_ear_development1.18023359
101MP0004142_abnormal_muscle_tone1.17341904
102MP0003283_abnormal_digestive_organ1.17257193
103MP0008007_abnormal_cellular_replicative1.15336791
104MP0002736_abnormal_nociception_after1.14087568
105MP0004215_abnormal_myocardial_fiber1.13734992
106MP0002277_abnormal_respiratory_mucosa1.12730763
107MP0004147_increased_porphyrin_level1.12281167
108MP0002752_abnormal_somatic_nervous1.12179466
109MP0003890_abnormal_embryonic-extraembry1.11074274
110MP0000026_abnormal_inner_ear1.10429134
111MP0002229_neurodegeneration1.10342676
112MP0003879_abnormal_hair_cell1.10095401
113MP0001764_abnormal_homeostasis1.08882448
114MP0001286_abnormal_eye_development1.08708910
115MP0001963_abnormal_hearing_physiology1.07210150
116MP0001440_abnormal_grooming_behavior1.03538305
117MP0002751_abnormal_autonomic_nervous1.02237532
118MP0003329_amyloid_beta_deposits1.02211105
119MP0008569_lethality_at_weaning1.01810888
120MP0002735_abnormal_chemical_nociception1.01185152
121MP0003787_abnormal_imprinting0.98102196
122MP0005377_hearing/vestibular/ear_phenot0.97839019
123MP0003878_abnormal_ear_physiology0.97839019
124MP0003137_abnormal_impulse_conducting0.97000806
125MP0000003_abnormal_adipose_tissue0.96526252
126MP0002928_abnormal_bile_duct0.96485301
127MP0004924_abnormal_behavior0.95489433
128MP0005386_behavior/neurological_phenoty0.95489433
129MP0008872_abnormal_physiological_respon0.93619009
130MP0000462_abnormal_digestive_system0.93276311
131MP0002066_abnormal_motor_capabilities/c0.93236626
132MP0002697_abnormal_eye_size0.92701346
133MP0003119_abnormal_digestive_system0.91819395
134MP0005409_darkened_coat_color0.90761018
135MP0000516_abnormal_urinary_system0.90557507
136MP0005367_renal/urinary_system_phenotyp0.90557507
137MP0002090_abnormal_vision0.89769528
138MP0001929_abnormal_gametogenesis0.87161456
139MP0005220_abnormal_exocrine_pancreas0.86421312
140MP0001324_abnormal_eye_pigmentation0.85933439
141MP0002152_abnormal_brain_morphology0.85717756
142MP0005195_abnormal_posterior_eye0.85311527
143MP0001664_abnormal_digestion0.84614746
144MP0003195_calcinosis0.83844145
145MP0002210_abnormal_sex_determination0.83047808
146MP0000049_abnormal_middle_ear0.82727994
147MP0000647_abnormal_sebaceous_gland0.82128540
148MP0000653_abnormal_sex_gland0.81956497
149MP0001145_abnormal_male_reproductive0.80963320
150MP0004145_abnormal_muscle_electrophysio0.80120402
151MP0002160_abnormal_reproductive_system0.79156004
152MP0001299_abnormal_eye_distance/0.78004826
153MP0000566_synostosis0.77506859
154MP0001346_abnormal_lacrimal_gland0.73664731
155MP0005389_reproductive_system_phenotype0.73138844
156MP0003698_abnormal_male_reproductive0.73068325
157MP0002009_preneoplasia0.72642197
158MP0003755_abnormal_palate_morphology0.72283047

Predicted human phenotypes

RankGene SetZ-score
1Retinal dysplasia (HP:0007973)3.90835252
2Congenital primary aphakia (HP:0007707)3.80907969
3Gait imbalance (HP:0002141)3.77355486
4Increased hepatocellular lipid droplets (HP:0006565)3.76807938
5Medial flaring of the eyebrow (HP:0010747)3.76387875
6Hypothermia (HP:0002045)3.68786572
7Acute necrotizing encephalopathy (HP:0006965)3.65683152
8Nephrogenic diabetes insipidus (HP:0009806)3.49971556
9Lipid accumulation in hepatocytes (HP:0006561)3.42510166
10Abnormal mitochondria in muscle tissue (HP:0008316)3.20226570
11Abnormal ciliary motility (HP:0012262)3.19670204
12Cerebral edema (HP:0002181)3.16763739
13Atonic seizures (HP:0010819)3.16399430
14Vaginal atresia (HP:0000148)3.15439499
15Abnormal respiratory motile cilium physiology (HP:0012261)3.12309761
16Colon cancer (HP:0003003)3.08951344
17Progressive macrocephaly (HP:0004481)3.08429332
18Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.07311846
19Genital tract atresia (HP:0001827)3.06434745
20True hermaphroditism (HP:0010459)3.01868952
21Abnormality of calcium-phosphate metabolism (HP:0100530)3.01466795
22Focal motor seizures (HP:0011153)2.97804856
23Hepatic necrosis (HP:0002605)2.97801602
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.94127356
25Aplasia/Hypoplasia of the lens (HP:0008063)2.91910478
26Decreased circulating renin level (HP:0003351)2.88685248
27Abnormality of macular pigmentation (HP:0008002)2.85696353
28Pheochromocytoma (HP:0002666)2.81766063
29Neuroendocrine neoplasm (HP:0100634)2.79857229
30Epileptic encephalopathy (HP:0200134)2.77298659
31Pancreatic fibrosis (HP:0100732)2.74618096
32Symptomatic seizures (HP:0011145)2.73863542
33Hyperglycinemia (HP:0002154)2.70693442
34Abnormality of midbrain morphology (HP:0002418)2.69153058
35Molar tooth sign on MRI (HP:0002419)2.69153058
36Acute encephalopathy (HP:0006846)2.66193112
37Mitochondrial inheritance (HP:0001427)2.64291984
383-Methylglutaconic aciduria (HP:0003535)2.64249725
39Abnormality of the labia minora (HP:0012880)2.64028481
40Neurofibrillary tangles (HP:0002185)2.62410095
41Poor coordination (HP:0002370)2.61380753
42Rhinitis (HP:0012384)2.60270924
43Limb dystonia (HP:0002451)2.59656099
44Bifid tongue (HP:0010297)2.58889739
45Agitation (HP:0000713)2.58600151
46Hyperinsulinemic hypoglycemia (HP:0000825)2.52644274
47Abnormal respiratory epithelium morphology (HP:0012253)2.50562253
48Abnormal respiratory motile cilium morphology (HP:0005938)2.50562253
49Large for gestational age (HP:0001520)2.47236506
50Septo-optic dysplasia (HP:0100842)2.47151263
51Methylmalonic acidemia (HP:0002912)2.47117692
52Increased intramyocellular lipid droplets (HP:0012240)2.46956855
53Bronchiectasis (HP:0002110)2.46063707
54Hypoglycemic seizures (HP:0002173)2.45718405
55Split foot (HP:0001839)2.43887890
56Pancreatic cysts (HP:0001737)2.41889277
57Abnormality of the fovea (HP:0000493)2.38326876
58Visual hallucinations (HP:0002367)2.34390498
59Lactic acidosis (HP:0003128)2.33298503
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.32664419
61Postaxial foot polydactyly (HP:0001830)2.30928017
62Exertional dyspnea (HP:0002875)2.30911951
63Respiratory failure (HP:0002878)2.30689122
64Chronic bronchitis (HP:0004469)2.28988657
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.28246819
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.28246819
67Reticulocytopenia (HP:0001896)2.27122350
68Increased serum lactate (HP:0002151)2.22834162
69Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.22309496
70Degeneration of the lateral corticospinal tracts (HP:0002314)2.22309496
71Exercise intolerance (HP:0003546)2.21583905
72Anencephaly (HP:0002323)2.20537891
73Epileptiform EEG discharges (HP:0011182)2.19729691
74Abnormal number of erythroid precursors (HP:0012131)2.19265052
75EEG with generalized epileptiform discharges (HP:0011198)2.18583254
76Absence seizures (HP:0002121)2.15258250
77Abnormality of the renal medulla (HP:0100957)2.14227902
78Congenital, generalized hypertrichosis (HP:0004540)2.13796158
79Optic disc pallor (HP:0000543)2.12932051
80Renal Fanconi syndrome (HP:0001994)2.12861293
81Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11579625
82Male pseudohermaphroditism (HP:0000037)2.11431019
83Hyperventilation (HP:0002883)2.10168767
84Abnormality of cells of the erythroid lineage (HP:0012130)2.10055170
85Abnormality of dentin (HP:0010299)2.09923211
86Abnormality of serum amino acid levels (HP:0003112)2.08597992
87Macrocytic anemia (HP:0001972)2.07572324
88Hypoplasia of the fovea (HP:0007750)2.07313113
89Aplasia/Hypoplasia of the fovea (HP:0008060)2.07313113
90Supernumerary spleens (HP:0009799)2.06827856
91Postaxial hand polydactyly (HP:0001162)2.06628006
92Occipital encephalocele (HP:0002085)2.06549984
93Abnormal rod and cone electroretinograms (HP:0008323)2.04528185
94Type II lissencephaly (HP:0007260)2.04321960
95Congenital sensorineural hearing impairment (HP:0008527)2.04112717
96Nuclear cataract (HP:0100018)2.03758897
97Nephronophthisis (HP:0000090)2.01181702
98Dialeptic seizures (HP:0011146)2.01117913
99Absent/shortened dynein arms (HP:0200106)2.00954160
100Dynein arm defect of respiratory motile cilia (HP:0012255)2.00954160
101Increased CSF lactate (HP:0002490)2.00933873
102Central scotoma (HP:0000603)1.99752957
103Abnormal biliary tract physiology (HP:0012439)1.99191228
104Bile duct proliferation (HP:0001408)1.99191228
105Febrile seizures (HP:0002373)1.99139774
106Type I transferrin isoform profile (HP:0003642)1.98969396
107Lethargy (HP:0001254)1.98450147
108Hypsarrhythmia (HP:0002521)1.98099305
109Intestinal atresia (HP:0011100)1.96005709
110Chronic hepatic failure (HP:0100626)1.95309879
111Hyperglycinuria (HP:0003108)1.95093233
112Methylmalonic aciduria (HP:0012120)1.94891334
113Abnormality of serine family amino acid metabolism (HP:0010894)1.94664116
114Abnormality of glycine metabolism (HP:0010895)1.94664116
115Abnormality of renal resorption (HP:0011038)1.94430344
116Median cleft lip (HP:0000161)1.94319734
117Increased muscle lipid content (HP:0009058)1.93782653
118Hypokalemia (HP:0002900)1.93183313
119Abnormal lung lobation (HP:0002101)1.92431109
120Abnormal protein glycosylation (HP:0012346)1.91570240
121Abnormal glycosylation (HP:0012345)1.91570240
122Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91570240
123Abnormal protein N-linked glycosylation (HP:0012347)1.91570240
124Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90990598
125Zonular cataract (HP:0010920)1.90878938
126Abnormality of the anterior horn cell (HP:0006802)1.89558440
127Degeneration of anterior horn cells (HP:0002398)1.89558440
128Megalencephaly (HP:0001355)1.89234407
129Abnormality of methionine metabolism (HP:0010901)1.89192349
130Preaxial hand polydactyly (HP:0001177)1.88681242
131Cerebral inclusion bodies (HP:0100314)1.88569837
132Meckel diverticulum (HP:0002245)1.86886722
133Leukodystrophy (HP:0002415)1.86753002
134Hemiparesis (HP:0001269)1.85693877
135Broad foot (HP:0001769)1.85533369
136Anxiety (HP:0000739)1.83918791
137Hyperparathyroidism (HP:0000843)1.81681942
138Abnormality of renin-angiotensin system (HP:0000847)1.81395508
139Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81090760
140Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80965506
141Stenosis of the external auditory canal (HP:0000402)1.80139055
142Congenital hepatic fibrosis (HP:0002612)1.79756157
143Progressive neurologic deterioration (HP:0002344)1.79538167
144Respiratory difficulties (HP:0002880)1.79422106
145Abnormality of the ileum (HP:0001549)1.79141598
146Triphalangeal thumb (HP:0001199)1.78392740
147Abolished electroretinogram (ERG) (HP:0000550)1.77861314
148Retinitis pigmentosa (HP:0000510)1.77702198
149Atelectasis (HP:0100750)1.76310810
150Aplasia/hypoplasia of the uterus (HP:0008684)1.76111616
151Anophthalmia (HP:0000528)1.75882281
152Anteriorly placed anus (HP:0001545)1.75575212
153Hepatocellular necrosis (HP:0001404)1.74557940
154Parakeratosis (HP:0001036)1.73592135
155Focal seizures (HP:0007359)1.71773184
156Increased serum pyruvate (HP:0003542)1.71739197
157Cystic liver disease (HP:0006706)1.71086427
158Abnormality of urine glucose concentration (HP:0011016)1.70025812
159Glycosuria (HP:0003076)1.70025812
160Sclerocornea (HP:0000647)1.69948821
161Absent septum pellucidum (HP:0001331)1.68075347
162Oculomotor apraxia (HP:0000657)1.67433597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK153.66049445
2VRK23.51415289
3CASK3.27285664
4BUB13.19381291
5WNK32.92528565
6INSRR2.71624691
7TNIK2.63412676
8BCKDK2.60731181
9STK392.58593230
10ZAK2.48681526
11WNK42.43075155
12CDC72.39745826
13NEK12.33698899
14SRPK12.25872831
15MAP4K22.22787107
16TRIM282.17017041
17MKNK12.16038685
18VRK12.12820144
19ARAF2.11531683
20PHKG11.96714216
21PHKG21.96714216
22MKNK21.96339727
23PLK31.95477075
24TTK1.89915506
25OXSR11.86777450
26WEE11.80652746
27NTRK31.79560385
28UHMK11.79470196
29BMPR21.78147554
30PASK1.78061580
31PLK41.75965572
32BCR1.75232316
33EPHA41.74429485
34MUSK1.72556380
35MAP2K71.66021780
36MAPK131.62118444
37NME11.62004778
38IRAK21.58161873
39ERBB31.55936509
40MAPKAPK51.53340623
41BRSK21.53261326
42PRKD31.48005880
43PAK31.44180536
44PRPF4B1.43909384
45STK161.42774220
46CAMK2D1.42183269
47HIPK21.40617956
48CAMK2B1.40555474
49ADRBK21.39422937
50MARK11.31476842
51EIF2AK11.29956001
52PLK11.29203750
53TAF11.27697159
54TSSK61.22551175
55GRK11.21854720
56BMPR1B1.21713682
57PLK21.18784206
58PRKCE1.15092789
59IRAK11.15000183
60BRAF1.14447075
61SGK4941.13181940
62SGK2231.13181940
63PNCK1.11138068
64MAP3K41.10548775
65DYRK1A1.07355244
66WNK11.06774687
67TLK11.03320681
68PKN11.03208656
69CDK191.02849399
70DYRK31.02500274
71CSNK1G31.02432230
72GRK51.01547106
73NTRK21.01045246
74CAMK2A1.00550139
75STK38L0.99845155
76NTRK10.99823849
77CSNK1A1L0.97991561
78PIK3CG0.97602217
79AKT30.96872648
80MAP3K20.96765039
81CAMKK20.94428151
82FRK0.93618177
83PINK10.91280229
84CDK30.90239243
85CDK50.87622242
86CSNK1G20.86425320
87CCNB10.86261390
88NEK60.86242729
89CAMK2G0.85379524
90FGFR20.83368277
91ADRBK10.81741770
92PDK20.80992781
93AURKB0.80409689
94ATR0.79912402
95PRKD20.78404531
96PRKCG0.74769457
97MINK10.74624368
98CSNK1G10.73155093
99ACVR1B0.72919378
100NUAK10.71650133
101DYRK20.71006219
102EIF2AK20.69945255
103PAK60.68945130
104RPS6KA40.68713301
105CHEK20.65297559
106FGR0.65123452
107TGFBR10.62972442
108BRSK10.60799681
109OBSCN0.60549469
110MST40.59679492
111PRKACA0.59167908
112TIE10.58941493
113LIMK10.58622264
114CSNK2A10.57714037
115PRKG10.57525157
116CDC42BPA0.56864536
117YES10.56713684
118MAP3K120.55292064
119MARK20.54917535
120STK30.54780066
121EPHA30.53535619
122ATM0.52980671
123CSNK2A20.51919298
124ROCK20.51893775
125EIF2AK30.51691261
126CDK140.50971612
127STK40.50022901
128DYRK1B0.49519050
129PRKCQ0.45069620
130NEK20.44228067
131CSNK1A10.43529565
132GRK70.43187991
133STK240.41601653
134AURKA0.40484332
135PRKCI0.40359676
136NME20.40037078
137TNK20.39587880
138SGK20.37842404
139CAMK10.37765361
140PRKCH0.37730003
141RPS6KA50.37471798
142CDK180.37065325
143PBK0.36871579
144MET0.36372727
145CSNK1E0.36229451
146CDK80.35349076
147CDK150.34449939
148FLT30.34380178
149SGK10.33897847
150PRKCA0.33848116
151CDK11A0.32809042
152NLK0.31464093
153FGFR10.30012937
154DAPK10.28252004
155TEC0.27924279

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.13400239
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.07684591
3Proteasome_Homo sapiens_hsa030503.39773221
4Ribosome_Homo sapiens_hsa030103.25814580
5Oxidative phosphorylation_Homo sapiens_hsa001902.90546991
6Olfactory transduction_Homo sapiens_hsa047402.89962801
7Mismatch repair_Homo sapiens_hsa034302.56536024
8RNA polymerase_Homo sapiens_hsa030202.46036656
9Sulfur metabolism_Homo sapiens_hsa009202.41940636
10Insulin secretion_Homo sapiens_hsa049112.39068369
11Parkinsons disease_Homo sapiens_hsa050122.27748489
12Homologous recombination_Homo sapiens_hsa034402.25874958
13Vibrio cholerae infection_Homo sapiens_hsa051102.21136685
14Propanoate metabolism_Homo sapiens_hsa006402.14664800
15GABAergic synapse_Homo sapiens_hsa047272.13291243
16DNA replication_Homo sapiens_hsa030302.10648178
17Alzheimers disease_Homo sapiens_hsa050102.08695870
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.05143215
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.04582009
20Nicotine addiction_Homo sapiens_hsa050332.00959965
21Taste transduction_Homo sapiens_hsa047422.00786022
22Circadian entrainment_Homo sapiens_hsa047131.99058289
23Morphine addiction_Homo sapiens_hsa050321.98703594
24Serotonergic synapse_Homo sapiens_hsa047261.97795828
25Collecting duct acid secretion_Homo sapiens_hsa049661.94377895
26Spliceosome_Homo sapiens_hsa030401.93787509
27Synaptic vesicle cycle_Homo sapiens_hsa047211.90741824
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.84944791
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83956876
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82340063
31Glutamatergic synapse_Homo sapiens_hsa047241.78251267
32Non-homologous end-joining_Homo sapiens_hsa034501.71586345
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70026696
34Dopaminergic synapse_Homo sapiens_hsa047281.65693034
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64766382
36Fanconi anemia pathway_Homo sapiens_hsa034601.62663315
37Amphetamine addiction_Homo sapiens_hsa050311.62074598
38RNA degradation_Homo sapiens_hsa030181.62074492
39Base excision repair_Homo sapiens_hsa034101.61472256
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61210844
41Steroid biosynthesis_Homo sapiens_hsa001001.58851387
42Cocaine addiction_Homo sapiens_hsa050301.56149894
43Nucleotide excision repair_Homo sapiens_hsa034201.55838684
44Huntingtons disease_Homo sapiens_hsa050161.51166944
45Phototransduction_Homo sapiens_hsa047441.49545072
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40467346
47Basal transcription factors_Homo sapiens_hsa030221.38773798
48Pyruvate metabolism_Homo sapiens_hsa006201.36573100
49RNA transport_Homo sapiens_hsa030131.36141311
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.35319274
51Cholinergic synapse_Homo sapiens_hsa047251.34114731
52Sphingolipid metabolism_Homo sapiens_hsa006001.30549291
53One carbon pool by folate_Homo sapiens_hsa006701.30225183
54Pyrimidine metabolism_Homo sapiens_hsa002401.27743268
55Ether lipid metabolism_Homo sapiens_hsa005651.26223628
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22677390
57Glutathione metabolism_Homo sapiens_hsa004801.22297665
58Fatty acid elongation_Homo sapiens_hsa000621.22263369
59Peroxisome_Homo sapiens_hsa041461.21363331
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18536624
61Long-term potentiation_Homo sapiens_hsa047201.18241867
62Cardiac muscle contraction_Homo sapiens_hsa042601.16642362
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16327855
64Purine metabolism_Homo sapiens_hsa002301.12701571
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08576750
66Salivary secretion_Homo sapiens_hsa049701.08316539
67Renin secretion_Homo sapiens_hsa049241.07224933
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03283417
69Long-term depression_Homo sapiens_hsa047301.03275481
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99256730
71Folate biosynthesis_Homo sapiens_hsa007900.99091305
72Chemical carcinogenesis_Homo sapiens_hsa052040.96612946
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95864583
74beta-Alanine metabolism_Homo sapiens_hsa004100.94261394
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.93123625
76Type I diabetes mellitus_Homo sapiens_hsa049400.90976684
77Nitrogen metabolism_Homo sapiens_hsa009100.90853527
78Alcoholism_Homo sapiens_hsa050340.90686082
79Caffeine metabolism_Homo sapiens_hsa002320.90684407
80Circadian rhythm_Homo sapiens_hsa047100.90126330
81Gastric acid secretion_Homo sapiens_hsa049710.88056148
82Axon guidance_Homo sapiens_hsa043600.87765942
83Calcium signaling pathway_Homo sapiens_hsa040200.87569294
84Tryptophan metabolism_Homo sapiens_hsa003800.87141840
85Linoleic acid metabolism_Homo sapiens_hsa005910.86370787
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85454798
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85392078
88Other glycan degradation_Homo sapiens_hsa005110.84690410
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84512207
90Cell cycle_Homo sapiens_hsa041100.83850656
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82515985
92Fatty acid degradation_Homo sapiens_hsa000710.81452766
93cAMP signaling pathway_Homo sapiens_hsa040240.80193792
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78619314
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78453413
96Carbon metabolism_Homo sapiens_hsa012000.78022028
97Pancreatic secretion_Homo sapiens_hsa049720.77829222
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76999431
99Rheumatoid arthritis_Homo sapiens_hsa053230.76467652
100N-Glycan biosynthesis_Homo sapiens_hsa005100.75872942
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75390120
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74676461
103Retinol metabolism_Homo sapiens_hsa008300.74313845
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73725776
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73594831
106Selenocompound metabolism_Homo sapiens_hsa004500.71867044
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70377911
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68683250
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68190743
110Vitamin B6 metabolism_Homo sapiens_hsa007500.68004971
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67393929
112Regulation of autophagy_Homo sapiens_hsa041400.65451426
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65310975
114Type II diabetes mellitus_Homo sapiens_hsa049300.64220705
115Tyrosine metabolism_Homo sapiens_hsa003500.62977708
116Ovarian steroidogenesis_Homo sapiens_hsa049130.62200541
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61795708
118Fatty acid metabolism_Homo sapiens_hsa012120.60824877
119Biosynthesis of amino acids_Homo sapiens_hsa012300.60521072
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.59775112
121Oxytocin signaling pathway_Homo sapiens_hsa049210.59336744
122Basal cell carcinoma_Homo sapiens_hsa052170.59061293
123Gap junction_Homo sapiens_hsa045400.58326154
124Melanogenesis_Homo sapiens_hsa049160.56747314
125Arachidonic acid metabolism_Homo sapiens_hsa005900.56726805
126Oocyte meiosis_Homo sapiens_hsa041140.55253476
127Thyroid hormone synthesis_Homo sapiens_hsa049180.54474935
128Arginine and proline metabolism_Homo sapiens_hsa003300.54010898
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52939702
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52832821
131Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51955094
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51939416
133Sulfur relay system_Homo sapiens_hsa041220.51769216
134GnRH signaling pathway_Homo sapiens_hsa049120.51093946
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50889335
136mRNA surveillance pathway_Homo sapiens_hsa030150.48574582
137Ras signaling pathway_Homo sapiens_hsa040140.48336602
138Lysosome_Homo sapiens_hsa041420.46216894
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44840087
140Steroid hormone biosynthesis_Homo sapiens_hsa001400.43375512
141Hedgehog signaling pathway_Homo sapiens_hsa043400.41610941
142Estrogen signaling pathway_Homo sapiens_hsa049150.40303638
143Glucagon signaling pathway_Homo sapiens_hsa049220.39889631
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39830606
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39726879
146p53 signaling pathway_Homo sapiens_hsa041150.39318153
147Asthma_Homo sapiens_hsa053100.38959541
148Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38657563
149Phagosome_Homo sapiens_hsa041450.38401544
150Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38066011
151Dilated cardiomyopathy_Homo sapiens_hsa054140.36755552
152Phenylalanine metabolism_Homo sapiens_hsa003600.36209903
153Histidine metabolism_Homo sapiens_hsa003400.35940441
154Drug metabolism - other enzymes_Homo sapiens_hsa009830.33679629
155Vitamin digestion and absorption_Homo sapiens_hsa049770.32779558
156Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29443086
157Wnt signaling pathway_Homo sapiens_hsa043100.27298220
158Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25961827
159Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25848594
160Systemic lupus erythematosus_Homo sapiens_hsa053220.25604480
161Sphingolipid signaling pathway_Homo sapiens_hsa040710.24520315
162Metabolic pathways_Homo sapiens_hsa011000.24089732
163ErbB signaling pathway_Homo sapiens_hsa040120.23576948
164Autoimmune thyroid disease_Homo sapiens_hsa053200.20570634
165Glycosaminoglycan degradation_Homo sapiens_hsa005310.20352476
166Butanoate metabolism_Homo sapiens_hsa006500.16382905
167Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14875689
168MAPK signaling pathway_Homo sapiens_hsa040100.14331453

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