HMGN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.07096809
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.86698254
3regulation of B cell receptor signaling pathway (GO:0050855)3.56638049
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.56611937
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.55254530
6antigen processing and presentation of endogenous antigen (GO:0019883)3.43703868
7activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.42806764
8negative regulation of cell killing (GO:0031342)3.37403610
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.37403610
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.37206410
11positive regulation of B cell differentiation (GO:0045579)3.36596520
12negative T cell selection (GO:0043383)3.27449021
13nuclear pore complex assembly (GO:0051292)3.24844708
14formation of translation preinitiation complex (GO:0001731)3.19804763
15negative thymic T cell selection (GO:0045060)3.19023699
16Golgi transport vesicle coating (GO:0048200)3.17275319
17COPI coating of Golgi vesicle (GO:0048205)3.17275319
18RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.10359426
19tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.10359426
20response to interleukin-15 (GO:0070672)3.09979853
21ribosome assembly (GO:0042255)3.09149574
22establishment of integrated proviral latency (GO:0075713)3.05648839
23hepatocyte apoptotic process (GO:0097284)3.05344243
24folic acid-containing compound biosynthetic process (GO:0009396)3.04898827
25proteasome assembly (GO:0043248)3.04537954
26IMP biosynthetic process (GO:0006188)3.03636926
27regulation of B cell differentiation (GO:0045577)3.03101004
28Arp2/3 complex-mediated actin nucleation (GO:0034314)2.98253061
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.94503711
30T cell migration (GO:0072678)2.91246450
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91123646
32cellular response to interleukin-15 (GO:0071350)2.90013283
33nuclear pore organization (GO:0006999)2.89591774
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.86764147
35antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.86521681
36regulation of alpha-beta T cell proliferation (GO:0046640)2.84238655
37pore complex assembly (GO:0046931)2.82197656
38neutrophil activation involved in immune response (GO:0002283)2.81081598
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.80294398
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.78613987
41positive regulation of alpha-beta T cell proliferation (GO:0046641)2.75951711
42establishment of viral latency (GO:0019043)2.71391584
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.67677772
44negative regulation of ligase activity (GO:0051352)2.67677772
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.67491164
46IMP metabolic process (GO:0046040)2.60706519
47DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.58866470
48signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.57822001
49intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.57822001
50negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.56194033
51purine nucleotide salvage (GO:0032261)2.55345241
52signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.54460215
53signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.54460215
54signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.54460215
55antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.53654286
56positive regulation of granulocyte differentiation (GO:0030854)2.48615194
57signal transduction involved in DNA integrity checkpoint (GO:0072401)2.48165900
58signal transduction involved in DNA damage checkpoint (GO:0072422)2.48165900
59signal transduction involved in cell cycle checkpoint (GO:0072395)2.46877305
60regulation of regulatory T cell differentiation (GO:0045589)2.42306653
61ribosome biogenesis (GO:0042254)2.42033886
62positive regulation of macrophage differentiation (GO:0045651)2.41440462
63regulation of gamma-delta T cell differentiation (GO:0045586)2.41322533
64DNA unwinding involved in DNA replication (GO:0006268)2.40113637
65positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.39711276
66leukocyte aggregation (GO:0070486)2.38535835
67regulation of cellular amino acid metabolic process (GO:0006521)2.38494490
68cullin deneddylation (GO:0010388)2.38164463
69transcription from mitochondrial promoter (GO:0006390)2.37294963
70purine nucleobase biosynthetic process (GO:0009113)2.36990853
71regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.34887650
72regulation of natural killer cell mediated immunity (GO:0002715)2.34887650
73DNA ligation (GO:0006266)2.33475254
74COPII vesicle coating (GO:0048208)2.32569909
75proline biosynthetic process (GO:0006561)2.32139880
76regulation of retinoic acid receptor signaling pathway (GO:0048385)2.32127988
77GMP metabolic process (GO:0046037)2.31752915
78protein deneddylation (GO:0000338)2.31684663
79positive regulation of ligase activity (GO:0051351)2.29239654
80positive regulation of T cell mediated cytotoxicity (GO:0001916)2.28774099
81regulation of gamma-delta T cell activation (GO:0046643)2.27508091
82positive regulation of natural killer cell mediated immunity (GO:0002717)2.26056034
83deoxyribonucleotide biosynthetic process (GO:0009263)2.25818452
84thymic T cell selection (GO:0045061)2.24608626
85DNA strand elongation involved in DNA replication (GO:0006271)2.22952588
86negative regulation of T cell mediated immunity (GO:0002710)2.21946039
87regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.21396854
88T cell selection (GO:0045058)2.21386485
89mitotic nuclear envelope disassembly (GO:0007077)2.21184948
90positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.20927021
91rRNA modification (GO:0000154)2.20919182
92protein maturation by protein folding (GO:0022417)2.20431651
93DNA strand elongation (GO:0022616)2.19928367
94regulation of T cell tolerance induction (GO:0002664)2.19479574
95antigen processing and presentation via MHC class Ib (GO:0002475)2.19456158
96mitochondrial RNA metabolic process (GO:0000959)2.19006269
97regulation of sister chromatid cohesion (GO:0007063)2.18829917
98programmed necrotic cell death (GO:0097300)2.17832258
99peptidyl-arginine omega-N-methylation (GO:0035247)2.16876041
100regulation of ubiquitin-protein transferase activity (GO:0051438)2.16692239

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.84808368
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.50273272
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15457738
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.03327687
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77126995
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.67815049
7* GABP_17652178_ChIP-ChIP_JURKAT_Human2.66895690
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.52615631
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.50950228
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.45212618
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.43005465
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36225708
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30938837
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.30877535
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25237166
16HOXB4_20404135_ChIP-ChIP_EML_Mouse2.24016600
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.23935449
18* VDR_23849224_ChIP-Seq_CD4+_Human2.23128899
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18514375
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16432326
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.14257546
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14077969
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08353682
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07516333
25ELK1_19687146_ChIP-ChIP_HELA_Human2.06781252
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06760550
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06049115
28MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00748498
29* FOXP3_21729870_ChIP-Seq_TREG_Human1.99509527
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99167781
31* MYB_26560356_Chip-Seq_TH2_Human1.96082548
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96045654
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.95821209
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.95581800
35SPI1_23547873_ChIP-Seq_NB4_Human1.90049086
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87191769
37DCP1A_22483619_ChIP-Seq_HELA_Human1.84238178
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82991500
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.80079906
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71581502
41CIITA_25753668_ChIP-Seq_RAJI_Human1.67660530
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.67044471
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65857536
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64574378
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64549744
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63463703
47* MYC_22102868_ChIP-Seq_BL_Human1.63226377
48* GABP_19822575_ChIP-Seq_HepG2_Human1.60313634
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59765027
50* MYB_26560356_Chip-Seq_TH1_Human1.57186915
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57101132
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.55324959
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54952912
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52206833
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51777579
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50338227
57TFEB_21752829_ChIP-Seq_HELA_Human1.48951307
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47837278
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.47371744
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.46564787
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46526164
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45642599
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42561789
64XRN2_22483619_ChIP-Seq_HELA_Human1.41819112
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.35606204
66* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33889053
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33323527
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.30906482
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29274724
70MAF_26560356_Chip-Seq_TH1_Human1.28004606
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27988800
72TTF2_22483619_ChIP-Seq_HELA_Human1.23228629
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22639606
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.22385350
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.17264841
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17006660
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15377157
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13685999
79KDM5A_27292631_Chip-Seq_BREAST_Human1.12904285
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12796550
81* UTX_26944678_Chip-Seq_JUKART_Human1.12637961
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11921852
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10979023
84AR_21909140_ChIP-Seq_LNCAP_Human1.08192755
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07012545
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06037461
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05296708
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04428167
89RUNX1_22412390_ChIP-Seq_EML_Mouse1.01821731
90BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01559927
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00670111
92GATA3_27048872_Chip-Seq_THYMUS_Human1.00314873
93* MAF_26560356_Chip-Seq_TH2_Human1.00078872
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99958945
95FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99733874
96KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97402885
97* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96351439
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95825184
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95437923
100GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95432586

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.13181055
2MP0003763_abnormal_thymus_physiology3.04038940
3MP0005671_abnormal_response_to2.80798834
4MP0009333_abnormal_splenocyte_physiolog2.57700615
5MP0002396_abnormal_hematopoietic_system2.57442324
6MP0004957_abnormal_blastocyst_morpholog2.42313008
7MP0002166_altered_tumor_susceptibility2.30507206
8MP0001800_abnormal_humoral_immune2.25710038
9MP0010094_abnormal_chromosome_stability2.23886086
10MP0003806_abnormal_nucleotide_metabolis2.23049389
11MP0003111_abnormal_nucleus_morphology2.19857634
12MP0003436_decreased_susceptibility_to2.12629338
13MP0003693_abnormal_embryo_hatching2.12137820
14MP0008260_abnormal_autophagy2.09710415
15MP0002877_abnormal_melanocyte_morpholog2.08963913
16MP0002398_abnormal_bone_marrow2.08732035
17MP0003077_abnormal_cell_cycle2.06834979
18MP0000685_abnormal_immune_system2.05557908
19MP0005000_abnormal_immune_tolerance2.05240303
20MP0005464_abnormal_platelet_physiology2.03146515
21MP0000703_abnormal_thymus_morphology2.01510897
22MP0003724_increased_susceptibility_to2.01073536
23MP0010352_gastrointestinal_tract_polyps1.99913150
24MP0003221_abnormal_cardiomyocyte_apopto1.99134184
25MP0002006_tumorigenesis1.97468818
26MP0008058_abnormal_DNA_repair1.94651100
27MP0002452_abnormal_antigen_presenting1.90699733
28MP0008057_abnormal_DNA_replication1.90588620
29MP0002420_abnormal_adaptive_immunity1.90377151
30MP0001819_abnormal_immune_cell1.89793217
31MP0002723_abnormal_immune_serum1.89090324
32MP0009785_altered_susceptibility_to1.85322611
33MP0002722_abnormal_immune_system1.82725801
34MP0001790_abnormal_immune_system1.76903766
35MP0005387_immune_system_phenotype1.76903766
36MP0003300_gastrointestinal_ulcer1.75864697
37MP0000689_abnormal_spleen_morphology1.73683172
38MP0000716_abnormal_immune_system1.67516634
39MP0002132_abnormal_respiratory_system1.62934341
40MP0008932_abnormal_embryonic_tissue1.61123597
41MP0002148_abnormal_hypersensitivity_rea1.60263063
42MP0002429_abnormal_blood_cell1.58158491
43MP0005025_abnormal_response_to1.57383702
44MP0000858_altered_metastatic_potential1.53155951
45MP0002419_abnormal_innate_immunity1.51650267
46MP0005075_abnormal_melanosome_morpholog1.50092596
47MP0000465_gastrointestinal_hemorrhage1.48205169
48MP0000490_abnormal_crypts_of1.47194259
49MP0009697_abnormal_copulation1.44856328
50MP0002009_preneoplasia1.39747259
51MP0003866_abnormal_defecation1.39130374
52MP0003183_abnormal_peptide_metabolism1.37468359
53MP0001730_embryonic_growth_arrest1.32229266
54MP0010155_abnormal_intestine_physiology1.31497534
55MP0003566_abnormal_cell_adhesion1.31336985
56MP0005451_abnormal_body_composition1.29782033
57MP0000350_abnormal_cell_proliferation1.27548853
58MP0002405_respiratory_system_inflammati1.26788960
59MP0004947_skin_inflammation1.26408282
60MP0002019_abnormal_tumor_incidence1.26110201
61MP0001845_abnormal_inflammatory_respons1.22096397
62MP0003786_premature_aging1.19086994
63MP0001853_heart_inflammation1.18548222
64MP0000313_abnormal_cell_death1.17621364
65MP0008007_abnormal_cellular_replicative1.16464498
66MP0006035_abnormal_mitochondrial_morpho1.09160752
67MP0003191_abnormal_cellular_cholesterol1.03410722
68MP0003448_altered_tumor_morphology1.01734668
69MP0009763_increased_sensitivity_to0.99398106
70MP0000372_irregular_coat_pigmentation0.98938503
71MP0000358_abnormal_cell_content/0.98675763
72MP0003656_abnormal_erythrocyte_physiolo0.97980816
73MP0001533_abnormal_skeleton_physiology0.94106452
74MP0005621_abnormal_cell_physiology0.91724133
75MP0003186_abnormal_redox_activity0.90999208
76MP0001986_abnormal_taste_sensitivity0.90287127
77MP0008469_abnormal_protein_level0.89082516
78MP0005380_embryogenesis_phenotype0.86200903
79MP0001672_abnormal_embryogenesis/_devel0.86200903
80MP0004264_abnormal_extraembryonic_tissu0.85928345
81MP0002080_prenatal_lethality0.84795261
82MP0001661_extended_life_span0.83847805
83MP0001851_eye_inflammation0.83302671
84MP0005384_cellular_phenotype0.82837550
85MP0001243_abnormal_dermal_layer0.82189390
86MP0003984_embryonic_growth_retardation0.80823194
87MP0003303_peritoneal_inflammation0.80149816
88MP0002086_abnormal_extraembryonic_tissu0.79387352
89MP0001697_abnormal_embryo_size0.79286262
90MP0004883_abnormal_blood_vessel0.78199497
91MP0004808_abnormal_hematopoietic_stem0.77888761
92MP0002088_abnormal_embryonic_growth/wei0.77875226
93MP0006082_CNS_inflammation0.77795126
94MP0008873_increased_physiological_sensi0.71886329
95MP0004147_increased_porphyrin_level0.68786680
96MP0000516_abnormal_urinary_system0.67361439
97MP0005367_renal/urinary_system_phenotyp0.67361439
98MP0003943_abnormal_hepatobiliary_system0.67277957
99MP0004381_abnormal_hair_follicle0.66283822
100MP0003091_abnormal_cell_migration0.66193209

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.06769530
2Abnormality of T cell number (HP:0011839)3.71599479
3Increased IgM level (HP:0003496)3.56530756
4Eczematoid dermatitis (HP:0000976)3.37374929
5IgG deficiency (HP:0004315)3.33634548
6Abnormality of T cells (HP:0002843)3.32404387
7Panhypogammaglobulinemia (HP:0003139)3.30186968
8Autoimmune hemolytic anemia (HP:0001890)3.23352509
9Fatigue (HP:0012378)3.21385577
10Granulocytopenia (HP:0001913)3.18154149
11Recurrent viral infections (HP:0004429)3.16415764
12IgM deficiency (HP:0002850)3.07583290
13Severe combined immunodeficiency (HP:0004430)2.98010340
14Aplastic anemia (HP:0001915)2.97414025
15Chronic diarrhea (HP:0002028)2.90340430
16Petechiae (HP:0000967)2.82563330
17Abnormal delayed hypersensitivity skin test (HP:0002963)2.78172763
18Cholecystitis (HP:0001082)2.78167467
19Abnormal gallbladder physiology (HP:0012438)2.78167467
20Abnormality of T cell physiology (HP:0011840)2.77930940
21Gastrointestinal infarctions (HP:0005244)2.77097950
22Recurrent abscess formation (HP:0002722)2.72503991
23Acute hepatic failure (HP:0006554)2.71704946
24B lymphocytopenia (HP:0010976)2.69935697
25Combined immunodeficiency (HP:0005387)2.68459810
26Agammaglobulinemia (HP:0004432)2.67810657
27Eosinophilia (HP:0001880)2.67219017
28Elevated erythrocyte sedimentation rate (HP:0003565)2.65134840
29Meningitis (HP:0001287)2.60436701
30Recurrent bacterial skin infections (HP:0005406)2.57930969
31Abnormality of eosinophils (HP:0001879)2.56695689
32Lymphopenia (HP:0001888)2.52043618
33Spontaneous hematomas (HP:0007420)2.51428097
34Abnormality of cells of the lymphoid lineage (HP:0012140)2.49913786
35Increased serum pyruvate (HP:0003542)2.47202562
36Recurrent fungal infections (HP:0002841)2.46538779
37Abnormality of the fetal cardiovascular system (HP:0010948)2.44749112
38Abnormal umbilical cord blood vessels (HP:0011403)2.44749112
39Single umbilical artery (HP:0001195)2.44749112
40Abnormality of glycolysis (HP:0004366)2.43545658
41Encephalitis (HP:0002383)2.42444480
42Inflammation of the large intestine (HP:0002037)2.41632650
43Gastrointestinal inflammation (HP:0004386)2.39426500
44Lymphoma (HP:0002665)2.37765642
45IgA deficiency (HP:0002720)2.36834572
46Abnormality of B cell number (HP:0010975)2.36435453
47Hypoproteinemia (HP:0003075)2.33245291
48Hepatosplenomegaly (HP:0001433)2.26481367
49Pustule (HP:0200039)2.26377573
50Anorexia (HP:0002039)2.25371119
51Progressive external ophthalmoplegia (HP:0000590)2.24376003
52Microvesicular hepatic steatosis (HP:0001414)2.21920371
53Vasculitis (HP:0002633)2.21889210
54Chronic mucocutaneous candidiasis (HP:0002728)2.21844981
55Recurrent cutaneous fungal infections (HP:0011370)2.21844981
56Leukocytosis (HP:0001974)2.20813993
57Epistaxis (HP:0000421)2.20345215
58Chronic otitis media (HP:0000389)2.15483860
59Chest pain (HP:0100749)2.14973196
60Gingival bleeding (HP:0000225)2.14794203
61Urticaria (HP:0001025)2.13439393
62Abnormality of macrophages (HP:0004311)2.12305338
63Stomatitis (HP:0010280)2.12298906
64Obstructive lung disease (HP:0006536)2.07643258
65Chronic obstructive pulmonary disease (HP:0006510)2.07643258
66Myositis (HP:0100614)2.05285481
67Prolonged bleeding time (HP:0003010)2.04327921
68Hypergammaglobulinemia (HP:0010702)2.03942995
69Basal cell carcinoma (HP:0002671)2.01298448
70Mediastinal lymphadenopathy (HP:0100721)2.00897901
71Viral hepatitis (HP:0006562)1.99664270
72Abnormality of the prostate (HP:0008775)1.97031845
73Cellular immunodeficiency (HP:0005374)1.96668414
74Type I transferrin isoform profile (HP:0003642)1.96218040
75Degeneration of anterior horn cells (HP:0002398)1.95903415
76Abnormality of the anterior horn cell (HP:0006802)1.95903415
77Osteomyelitis (HP:0002754)1.95798321
78Recurrent skin infections (HP:0001581)1.93291402
79Abnormal platelet volume (HP:0011876)1.91399441
80Arterial thrombosis (HP:0004420)1.90329423
81Verrucae (HP:0200043)1.90146923
82Papilloma (HP:0012740)1.90146923
83Cutaneous melanoma (HP:0012056)1.90112796
84Recurrent bronchitis (HP:0002837)1.89727214
85Colitis (HP:0002583)1.88883308
86Abnormality of the umbilical cord (HP:0010881)1.88645855
87Joint swelling (HP:0001386)1.87893442
88Aplasia/Hypoplasia of the thymus (HP:0010515)1.86286397
89Hypoplasia of the thymus (HP:0000778)1.86203353
90Hypertensive crisis (HP:0100735)1.84072018
91Orthostatic hypotension (HP:0001278)1.81373861
92Micronodular cirrhosis (HP:0001413)1.80519341
93Glomerulopathy (HP:0100820)1.80219295
94Oral leukoplakia (HP:0002745)1.78999391
95Rough bone trabeculation (HP:0100670)1.77087118
96Cellulitis (HP:0100658)1.75366412
97Myelodysplasia (HP:0002863)1.73941942
98Upper limb muscle weakness (HP:0003484)1.73682944
99Abnormality of oral frenula (HP:0000190)1.72806631
100Skin rash (HP:0000988)1.72405861

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.11310207
2SRPK13.09268872
3TESK22.92787019
4SIK32.83648109
5BUB12.75936499
6TXK2.42547305
7TRIM282.37130786
8EIF2AK12.30523008
9MAP4K12.18000085
10BMPR22.12407158
11BCR2.12042251
12MAP2K32.10322350
13RIPK42.08847475
14JAK31.99577387
15EIF2AK31.98757294
16SCYL21.91830683
17CDK191.86431121
18STK101.80783524
19PRPF4B1.80470657
20RPS6KA41.75850227
21TSSK61.69526051
22FGR1.58865278
23NME21.55681854
24TYK21.51303907
25PAK41.50350658
26MAP3K141.50269460
27NEK11.45509351
28PBK1.41163576
29MAP3K121.40202577
30PASK1.35548592
31TESK11.25712213
32MAP3K31.22866798
33ERBB31.16343673
34GRK61.13304042
35JAK11.04869819
36MAP3K81.04530515
37CLK11.04139582
38LRRK21.03934740
39NEK90.99789307
40VRK20.99718487
41BTK0.97914608
42IRAK40.97160640
43VRK10.94061484
44ZAP700.93654811
45RAF10.93040805
46CDK60.91995447
47KDR0.91970525
48EPHB10.90927046
49FGFR40.89021275
50MAP3K130.85140618
51STK40.84195832
52PLK30.82469832
53CDK90.81701497
54MAP3K100.81682019
55BCKDK0.81252667
56ZAK0.80973012
57MAP4K20.80903589
58JAK20.80467186
59CSK0.80232649
60TEC0.79127297
61TBK10.76733528
62SYK0.74340551
63YES10.73864122
64ITK0.72213852
65LCK0.71674084
66CSF1R0.71659681
67TTK0.70625559
68MARK30.69022963
69KSR10.68971424
70CDK70.68636375
71LYN0.65481889
72MAP3K50.65440348
73PLK40.64117241
74FES0.63844313
75HCK0.62827986
76ILK0.62789778
77PIK3CG0.62492652
78TAOK30.61947447
79TAOK20.61183886
80KSR20.60055932
81TRPM70.59904680
82IKBKE0.56900752
83CSNK1G30.55535070
84BMX0.52060505
85AURKB0.51369548
86CDK40.50761028
87ATR0.50126268
88FGFR30.49927338
89CSNK1A1L0.49734389
90RPS6KA50.48373781
91CCNB10.47998027
92ARAF0.47563482
93MAPKAPK20.47220201
94PIM10.44995504
95NEK60.43052801
96CDK80.42629565
97ERBB40.42406286
98LIMK10.40363375
99IRAK10.40158594
100BRD40.39920752

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.51436041
2Primary immunodeficiency_Homo sapiens_hsa053403.16167268
3DNA replication_Homo sapiens_hsa030302.50554695
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.45578866
5Spliceosome_Homo sapiens_hsa030402.26106958
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19179331
7Mismatch repair_Homo sapiens_hsa034302.13079780
8Non-homologous end-joining_Homo sapiens_hsa034502.06667651
9Base excision repair_Homo sapiens_hsa034102.06399963
10Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.05506834
11Antigen processing and presentation_Homo sapiens_hsa046121.98063412
12Measles_Homo sapiens_hsa051621.90396375
13RNA transport_Homo sapiens_hsa030131.84752102
14Shigellosis_Homo sapiens_hsa051311.71702363
15Allograft rejection_Homo sapiens_hsa053301.65825467
16Graft-versus-host disease_Homo sapiens_hsa053321.62633211
17Autoimmune thyroid disease_Homo sapiens_hsa053201.61072593
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.56139151
19Herpes simplex infection_Homo sapiens_hsa051681.53786109
20Nucleotide excision repair_Homo sapiens_hsa034201.46525116
21T cell receptor signaling pathway_Homo sapiens_hsa046601.46171876
22Cell cycle_Homo sapiens_hsa041101.44658873
23Viral myocarditis_Homo sapiens_hsa054161.40725223
24Viral carcinogenesis_Homo sapiens_hsa052031.40641448
25Epstein-Barr virus infection_Homo sapiens_hsa051691.37590110
26Legionellosis_Homo sapiens_hsa051341.37509116
27Biosynthesis of amino acids_Homo sapiens_hsa012301.32224474
28mRNA surveillance pathway_Homo sapiens_hsa030151.32114824
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30804990
30One carbon pool by folate_Homo sapiens_hsa006701.29450859
31Hematopoietic cell lineage_Homo sapiens_hsa046401.29081389
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.27016434
33Pentose phosphate pathway_Homo sapiens_hsa000301.22006017
34Basal transcription factors_Homo sapiens_hsa030221.20443242
35B cell receptor signaling pathway_Homo sapiens_hsa046621.20027447
36Pyrimidine metabolism_Homo sapiens_hsa002401.18227285
37Leishmaniasis_Homo sapiens_hsa051401.12686489
38RNA polymerase_Homo sapiens_hsa030201.12337115
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12297900
40Apoptosis_Homo sapiens_hsa042101.11944010
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09377731
42RNA degradation_Homo sapiens_hsa030181.08379249
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06192221
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05196690
45Hepatitis B_Homo sapiens_hsa051611.05030910
46Type I diabetes mellitus_Homo sapiens_hsa049401.03526938
47Influenza A_Homo sapiens_hsa051641.02135797
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01622124
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97611865
50Acute myeloid leukemia_Homo sapiens_hsa052210.96294039
51p53 signaling pathway_Homo sapiens_hsa041150.95389509
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94865057
53Pancreatic cancer_Homo sapiens_hsa052120.92647773
54Carbon metabolism_Homo sapiens_hsa012000.92530716
55Thyroid cancer_Homo sapiens_hsa052160.91649601
56Protein export_Homo sapiens_hsa030600.89987873
57Fatty acid elongation_Homo sapiens_hsa000620.88449222
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88025741
59HTLV-I infection_Homo sapiens_hsa051660.86504492
60Osteoclast differentiation_Homo sapiens_hsa043800.86501895
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84611139
62N-Glycan biosynthesis_Homo sapiens_hsa005100.83198489
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.81772323
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81598696
65Galactose metabolism_Homo sapiens_hsa000520.81475248
66Systemic lupus erythematosus_Homo sapiens_hsa053220.80190425
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.79073827
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78274685
69Non-small cell lung cancer_Homo sapiens_hsa052230.77009048
70Chronic myeloid leukemia_Homo sapiens_hsa052200.76546251
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72036055
72Colorectal cancer_Homo sapiens_hsa052100.71027871
73Homologous recombination_Homo sapiens_hsa034400.70842822
74Toxoplasmosis_Homo sapiens_hsa051450.70743187
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70698171
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.68419827
77Salmonella infection_Homo sapiens_hsa051320.67145191
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65408859
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.63071421
80Sulfur metabolism_Homo sapiens_hsa009200.62965661
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62431623
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.62247325
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61777784
84Fanconi anemia pathway_Homo sapiens_hsa034600.58249978
85Chemokine signaling pathway_Homo sapiens_hsa040620.58139332
86Tuberculosis_Homo sapiens_hsa051520.56026806
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55191776
88Purine metabolism_Homo sapiens_hsa002300.54973193
89Endocytosis_Homo sapiens_hsa041440.54757134
90Ribosome_Homo sapiens_hsa030100.52673522
91Phagosome_Homo sapiens_hsa041450.51404078
92Small cell lung cancer_Homo sapiens_hsa052220.50793250
93Glutathione metabolism_Homo sapiens_hsa004800.50162838
94Regulation of autophagy_Homo sapiens_hsa041400.49742667
95Vibrio cholerae infection_Homo sapiens_hsa051100.48447173
96Hepatitis C_Homo sapiens_hsa051600.47406318
97Fructose and mannose metabolism_Homo sapiens_hsa000510.45985093
98TNF signaling pathway_Homo sapiens_hsa046680.44105540
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43176756
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42990203

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