HMMR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.78540965
2mitotic metaphase plate congression (GO:0007080)5.56767310
3mitotic sister chromatid segregation (GO:0000070)5.51048254
4kinetochore organization (GO:0051383)5.44224364
5sister chromatid segregation (GO:0000819)5.33636571
6nuclear pore organization (GO:0006999)5.17667806
7mitotic chromosome condensation (GO:0007076)5.15476185
8protein localization to chromosome, centromeric region (GO:0071459)5.11911861
9nuclear pore complex assembly (GO:0051292)5.11801979
10metaphase plate congression (GO:0051310)5.02706447
11regulation of spindle organization (GO:0090224)4.87949588
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.86964375
13CENP-A containing nucleosome assembly (GO:0034080)4.70181830
14chromatin remodeling at centromere (GO:0031055)4.69190937
15attachment of spindle microtubules to kinetochore (GO:0008608)4.69175480
16kinetochore assembly (GO:0051382)4.69129299
17establishment of integrated proviral latency (GO:0075713)4.65695265
18establishment of chromosome localization (GO:0051303)4.61698684
19DNA unwinding involved in DNA replication (GO:0006268)4.54316009
20regulation of mitotic spindle organization (GO:0060236)4.53021471
21mitotic nuclear envelope disassembly (GO:0007077)4.52259467
22DNA ligation (GO:0006266)4.42821393
23meiotic chromosome segregation (GO:0045132)4.34916815
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.31050133
25DNA replication-dependent nucleosome organization (GO:0034723)4.28254740
26DNA replication-dependent nucleosome assembly (GO:0006335)4.28254740
27DNA replication-independent nucleosome assembly (GO:0006336)4.25050302
28DNA replication-independent nucleosome organization (GO:0034724)4.25050302
29membrane disassembly (GO:0030397)4.20677883
30nuclear envelope disassembly (GO:0051081)4.20677883
31positive regulation of chromosome segregation (GO:0051984)4.17752960
32DNA replication initiation (GO:0006270)4.16416086
33spindle checkpoint (GO:0031577)4.04950861
34histone exchange (GO:0043486)4.03292169
35positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.01392571
36positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.01392571
37positive regulation of mitotic sister chromatid separation (GO:1901970)4.01392571
38mitotic sister chromatid cohesion (GO:0007064)4.00629975
39pore complex assembly (GO:0046931)3.97519562
40regulation of chromosome segregation (GO:0051983)3.95010046
41DNA strand elongation involved in DNA replication (GO:0006271)3.93071511
42microtubule depolymerization (GO:0007019)3.86705608
43protein localization to chromosome (GO:0034502)3.85565574
44spindle assembly checkpoint (GO:0071173)3.82934896
45chromosome segregation (GO:0007059)3.82146300
46regulation of mitotic metaphase/anaphase transition (GO:0030071)3.79540287
47negative regulation of chromosome segregation (GO:0051985)3.79294409
48negative regulation of mitotic sister chromatid separation (GO:2000816)3.75145654
49negative regulation of mitotic sister chromatid segregation (GO:0033048)3.75145654
50negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.75145654
51negative regulation of sister chromatid segregation (GO:0033046)3.75145654
52DNA strand elongation (GO:0022616)3.74641648
53protein K6-linked ubiquitination (GO:0085020)3.74088943
54DNA replication checkpoint (GO:0000076)3.71554452
55regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.70330806
56mitotic recombination (GO:0006312)3.69118098
57telomere maintenance via semi-conservative replication (GO:0032201)3.69112034
58mitotic spindle checkpoint (GO:0071174)3.68877553
59regulation of centrosome cycle (GO:0046605)3.67538683
60mitotic spindle assembly checkpoint (GO:0007094)3.67189160
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.63356756
62regulation of mitotic sister chromatid segregation (GO:0033047)3.63178540
63regulation of sister chromatid segregation (GO:0033045)3.63178540
64regulation of mitotic sister chromatid separation (GO:0010965)3.63178540
65chromatin assembly or disassembly (GO:0006333)3.55399715
66chromosome condensation (GO:0030261)3.51813810
67telomere maintenance via recombination (GO:0000722)3.50332682
68DNA topological change (GO:0006265)3.50254106
69DNA geometric change (GO:0032392)3.48948736
70DNA duplex unwinding (GO:0032508)3.48316015
71regulation of sister chromatid cohesion (GO:0007063)3.47002080
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.46418177
73IMP biosynthetic process (GO:0006188)3.45937682
74establishment of viral latency (GO:0019043)3.45499793
75regulation of centriole replication (GO:0046599)3.42859898
76nucleobase biosynthetic process (GO:0046112)3.37845751
77regulation of histone H3-K9 methylation (GO:0051570)3.35745945
78double-strand break repair via nonhomologous end joining (GO:0006303)3.35623617
79non-recombinational repair (GO:0000726)3.35623617
80folic acid-containing compound biosynthetic process (GO:0009396)3.33145253
81ATP-dependent chromatin remodeling (GO:0043044)3.29637644
82heterochromatin organization (GO:0070828)3.27449236
83regulation of telomere maintenance via telomerase (GO:0032210)3.23970191
84protein complex localization (GO:0031503)3.23815809
85telomere maintenance via telomere lengthening (GO:0010833)3.23293655
86nuclear envelope organization (GO:0006998)3.21539876
87DNA conformation change (GO:0071103)3.20331193
88DNA packaging (GO:0006323)3.20303897
89regulation of DNA endoreduplication (GO:0032875)3.18354705
90regulation of translational fidelity (GO:0006450)3.14007660
91purine nucleobase biosynthetic process (GO:0009113)3.10228863
92anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08152968
93negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.07596558
94somatic hypermutation of immunoglobulin genes (GO:0016446)3.07219563
95somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07219563
96regulation of helicase activity (GO:0051095)3.06781728
97negative regulation of histone methylation (GO:0031061)3.05322231
98regulation of centrosome duplication (GO:0010824)3.03722025
99mitotic cell cycle (GO:0000278)3.02029060
100negative regulation of DNA-dependent DNA replication (GO:2000104)3.01963478
101nucleotide-excision repair, DNA gap filling (GO:0006297)2.99858416
102IMP metabolic process (GO:0046040)2.98975593
103chromosome organization (GO:0051276)2.98041525
104mitotic spindle organization (GO:0007052)2.97437230
105ribosome assembly (GO:0042255)2.94182609
106formation of translation preinitiation complex (GO:0001731)2.93827858
107negative regulation of nuclear division (GO:0051784)2.93254574
108maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93058566
109maturation of SSU-rRNA (GO:0030490)2.89198613
110mitotic G2/M transition checkpoint (GO:0044818)2.89124955
111negative regulation of mitosis (GO:0045839)2.88949144
112dosage compensation (GO:0007549)2.87799165
113chromatin assembly (GO:0031497)2.87519887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human7.12085015
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.85159419
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.28890210
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.76083414
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.85936613
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77978047
7AR_21909140_ChIP-Seq_LNCAP_Human2.73266062
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.62775836
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60041655
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.58335898
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.56727522
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37118906
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.36049614
14* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.33674702
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.27695047
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25619796
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08459214
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07927232
19* EGR1_19374776_ChIP-ChIP_THP-1_Human2.06393439
20* XRN2_22483619_ChIP-Seq_HELA_Human2.00664326
21E2F7_22180533_ChIP-Seq_HELA_Human10.2490526
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99052063
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.97694960
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.87079376
25NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86916104
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86361112
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85844643
28VDR_23849224_ChIP-Seq_CD4+_Human1.82089096
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.79636447
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76722655
31* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74717142
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.69042111
33FOXP3_21729870_ChIP-Seq_TREG_Human1.68230623
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67497510
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66362311
36ELK1_19687146_ChIP-ChIP_HELA_Human1.65073691
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63057031
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60593363
39TTF2_22483619_ChIP-Seq_HELA_Human1.58626136
40DCP1A_22483619_ChIP-Seq_HELA_Human1.57155886
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.48217362
42CIITA_25753668_ChIP-Seq_RAJI_Human1.43754567
43* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40720214
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38545457
45KDM5A_27292631_Chip-Seq_BREAST_Human1.37060251
46MYC_22102868_ChIP-Seq_BL_Human1.35652354
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35216587
48GABP_19822575_ChIP-Seq_HepG2_Human1.34840249
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34337076
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31859945
51* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30269751
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30072291
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29896720
54* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29114662
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27780692
56* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26819417
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26342407
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22490528
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20329594
60* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20140755
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18543779
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17154996
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15139648
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13325130
65* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09557405
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08522748
67KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08522748
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08522748
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05723600
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03424089
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03109909
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01872611
73TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01568815
74SOX17_20123909_ChIP-Seq_XEN_Mouse1.01492145
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00422649
76NANOG_21062744_ChIP-ChIP_HESCs_Human1.00283658
77TFEB_21752829_ChIP-Seq_HELA_Human1.00140118
78YY1_21170310_ChIP-Seq_MESCs_Mouse0.98191508
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97690774
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95985587
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93369307
82ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93218321
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93144813
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92642307
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91904393
86TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91716385
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90358926
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90184502
89SRF_21415370_ChIP-Seq_HL-1_Mouse0.90084942
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89208797
91MYC_18940864_ChIP-ChIP_HL60_Human0.87371624
92NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.84782250
93* HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84780250
94CHD1_26751641_Chip-Seq_LNCaP_Human0.83510945
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82182631
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81815076
97SOX2_16153702_ChIP-ChIP_HESCs_Human0.81237274
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80122681
99NANOG_16153702_ChIP-ChIP_HESCs_Human0.79081107
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79029488
101SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.78797159
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78488776
103POU5F1_16153702_ChIP-ChIP_HESCs_Human0.77956863
104* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77686062
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.77590223
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.77540308
107EWS_26573619_Chip-Seq_HEK293_Human0.74569472
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72375311
109TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72176783
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71388354
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.69278367
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.67159842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.27530975
2MP0010094_abnormal_chromosome_stability4.92714107
3MP0003111_abnormal_nucleus_morphology4.89431995
4MP0003077_abnormal_cell_cycle4.24348981
5MP0004957_abnormal_blastocyst_morpholog4.16342221
6MP0008057_abnormal_DNA_replication3.91301299
7MP0008058_abnormal_DNA_repair3.11844017
8MP0008007_abnormal_cellular_replicative2.82499126
9MP0010307_abnormal_tumor_latency2.60710872
10MP0008932_abnormal_embryonic_tissue2.56843954
11MP0009697_abnormal_copulation2.52546548
12MP0001730_embryonic_growth_arrest2.39750855
13MP0003123_paternal_imprinting2.39417987
14MP0000350_abnormal_cell_proliferation2.33943642
15MP0010352_gastrointestinal_tract_polyps2.22619266
16MP0001672_abnormal_embryogenesis/_devel1.95946832
17MP0005380_embryogenesis_phenotype1.95946832
18MP0002396_abnormal_hematopoietic_system1.95810649
19MP0008877_abnormal_DNA_methylation1.95208216
20MP0005076_abnormal_cell_differentiation1.88807434
21MP0001697_abnormal_embryo_size1.84541749
22MP0003786_premature_aging1.77160357
23MP0002085_abnormal_embryonic_tissue1.74820208
24MP0003984_embryonic_growth_retardation1.74669807
25MP0002088_abnormal_embryonic_growth/wei1.71158378
26MP0003121_genomic_imprinting1.69177501
27MP0002084_abnormal_developmental_patter1.68303479
28MP0004197_abnormal_fetal_growth/weight/1.67973486
29MP0002086_abnormal_extraembryonic_tissu1.63767851
30MP0002080_prenatal_lethality1.60442138
31MP0010030_abnormal_orbit_morphology1.51832015
32MP0000490_abnormal_crypts_of1.50723576
33MP0003890_abnormal_embryonic-extraembry1.44416163
34MP0003567_abnormal_fetal_cardiomyocyte1.43420956
35MP0003718_maternal_effect1.42330288
36MP0001293_anophthalmia1.39682441
37MP0004808_abnormal_hematopoietic_stem1.39243168
38MP0003705_abnormal_hypodermis_morpholog1.38037411
39MP0000313_abnormal_cell_death1.37555491
40MP0003941_abnormal_skin_development1.30885799
41MP0009053_abnormal_anal_canal1.28597822
42MP0002019_abnormal_tumor_incidence1.26616219
43MP0003937_abnormal_limbs/digits/tail_de1.16341653
44MP0002210_abnormal_sex_determination1.15579710
45MP0000537_abnormal_urethra_morphology1.08060843
46MP0004185_abnormal_adipocyte_glucose1.07993244
47MP0005084_abnormal_gallbladder_morpholo1.03685449
48MP0001145_abnormal_male_reproductive1.02905614
49MP0002009_preneoplasia0.98912526
50MP0001529_abnormal_vocalization0.98853164
51MP0009672_abnormal_birth_weight0.98292146
52MP0002111_abnormal_tail_morphology0.96789596
53MP0009703_decreased_birth_body0.96772641
54MP0003566_abnormal_cell_adhesion0.95048751
55MP0006035_abnormal_mitochondrial_morpho0.94643360
56MP0000358_abnormal_cell_content/0.94630491
57MP0003315_abnormal_perineum_morphology0.94352303
58MP0005397_hematopoietic_system_phenotyp0.91702746
59MP0001545_abnormal_hematopoietic_system0.91702746
60MP0001929_abnormal_gametogenesis0.91531439
61MP0006054_spinal_hemorrhage0.90776317
62MP0003119_abnormal_digestive_system0.89755839
63MP0000703_abnormal_thymus_morphology0.88661526
64MP0000653_abnormal_sex_gland0.87479520
65MP0008961_abnormal_basal_metabolism0.86949086
66MP0001286_abnormal_eye_development0.86154148
67MP0001346_abnormal_lacrimal_gland0.85654382
68MP0001915_intracranial_hemorrhage0.83588148
69MP0005408_hypopigmentation0.81943350
70MP0005621_abnormal_cell_physiology0.81409084
71MP0005023_abnormal_wound_healing0.81044256
72MP0002697_abnormal_eye_size0.80918654
73MP0000432_abnormal_head_morphology0.80744722
74MP0006292_abnormal_olfactory_placode0.80518805
75MP0002092_abnormal_eye_morphology0.80113874
76MP0000428_abnormal_craniofacial_morphol0.79686724
77MP0003385_abnormal_body_wall0.79563091
78MP0005384_cellular_phenotype0.78726197
79MP0002796_impaired_skin_barrier0.77979990
80MP0004264_abnormal_extraembryonic_tissu0.77304534
81MP0003787_abnormal_imprinting0.77255548
82MP0003699_abnormal_female_reproductive0.77070048
83MP0001119_abnormal_female_reproductive0.76906452
84MP0005395_other_phenotype0.75155385
85MP0003806_abnormal_nucleotide_metabolis0.75086481
86MP0006072_abnormal_retinal_apoptosis0.74285891
87MP0001881_abnormal_mammary_gland0.73568641
88MP0002398_abnormal_bone_marrow0.72144601
89MP0004233_abnormal_muscle_weight0.71767646
90MP0002233_abnormal_nose_morphology0.71422292
91MP0009379_abnormal_foot_pigmentation0.71209477
92MP0004133_heterotaxia0.71149636
93MP0000733_abnormal_muscle_development0.70988095
94MP0002722_abnormal_immune_system0.70937502
95MP0002653_abnormal_ependyma_morphology0.69599778
96MP0003935_abnormal_craniofacial_develop0.69533716
97MP0008789_abnormal_olfactory_epithelium0.68592722
98MP0002925_abnormal_cardiovascular_devel0.68090468
99MP0003115_abnormal_respiratory_system0.68003876
100MP0000569_abnormal_digit_pigmentation0.67305938
101* MP0002161_abnormal_fertility/fecundity0.67283355
102MP0000579_abnormal_nail_morphology0.67201801
103MP0003186_abnormal_redox_activity0.66064339
104MP0001849_ear_inflammation0.65851809
105MP0004147_increased_porphyrin_level0.65787352
106MP0000858_altered_metastatic_potential0.65717136
107MP0009333_abnormal_splenocyte_physiolog0.65699905
108MP0002938_white_spotting0.64945414
109MP0001661_extended_life_span0.63831063
110MP0009278_abnormal_bone_marrow0.63717330
111MP0003698_abnormal_male_reproductive0.63497121
112MP0005389_reproductive_system_phenotype0.62388116
113MP0003943_abnormal_hepatobiliary_system0.62208904
114MP0000689_abnormal_spleen_morphology0.62091819
115MP0003221_abnormal_cardiomyocyte_apopto0.62044394
116MP0003755_abnormal_palate_morphology0.61482026
117MP0000762_abnormal_tongue_morphology0.61193555
118MP0003861_abnormal_nervous_system0.59933210
119MP0002160_abnormal_reproductive_system0.59851617
120MP0004272_abnormal_basement_membrane0.58325551
121MP0003448_altered_tumor_morphology0.58152238
122MP0005501_abnormal_skin_physiology0.57132902
123MP0002877_abnormal_melanocyte_morpholog0.56590669
124MP0000383_abnormal_hair_follicle0.56455708
125MP0002102_abnormal_ear_morphology0.55670945
126MP0010234_abnormal_vibrissa_follicle0.55361914
127MP0000477_abnormal_intestine_morphology0.54175170
128MP0002114_abnormal_axial_skeleton0.53121591
129MP0002095_abnormal_skin_pigmentation0.53105113
130MP0008770_decreased_survivor_rate0.52902108

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.16297876
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.97428815
3Abnormality of chromosome stability (HP:0003220)3.84238202
4Birth length less than 3rd percentile (HP:0003561)3.82563958
5Cortical dysplasia (HP:0002539)3.61340709
6Meckel diverticulum (HP:0002245)3.52050210
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.41931353
8Abnormality of the preputium (HP:0100587)3.37795204
9Reticulocytopenia (HP:0001896)3.35443735
10Abnormality of the ileum (HP:0001549)3.34984984
11Ependymoma (HP:0002888)3.34137516
12Impulsivity (HP:0100710)3.31983416
13Abnormality of the labia minora (HP:0012880)3.31754078
14Medulloblastoma (HP:0002885)3.31432163
15Small intestinal stenosis (HP:0012848)3.22425505
16Duodenal stenosis (HP:0100867)3.22425505
17Volvulus (HP:0002580)3.19133786
18Patellar aplasia (HP:0006443)3.17246665
19Selective tooth agenesis (HP:0001592)3.12219855
20Ectopic kidney (HP:0000086)3.01095406
21Increased nuchal translucency (HP:0010880)2.98469201
22Colon cancer (HP:0003003)2.97620474
23Absent radius (HP:0003974)2.96898924
24Breast hypoplasia (HP:0003187)2.96672475
25Aplasia/Hypoplasia of the patella (HP:0006498)2.91669095
26Myelodysplasia (HP:0002863)2.91348879
27Absent forearm bone (HP:0003953)2.76227661
28Aplasia involving forearm bones (HP:0009822)2.76227661
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.75875356
30Multiple enchondromatosis (HP:0005701)2.69792965
31Abnormal lung lobation (HP:0002101)2.69668012
32Abnormality of the duodenum (HP:0002246)2.66747238
33Agnosia (HP:0010524)2.66039438
34Deviation of the thumb (HP:0009603)2.64920096
35Rhabdomyosarcoma (HP:0002859)2.64511627
36Proximal placement of thumb (HP:0009623)2.61625208
37Sloping forehead (HP:0000340)2.61195586
38Nephroblastoma (Wilms tumor) (HP:0002667)2.59278339
39Carpal bone hypoplasia (HP:0001498)2.54105749
40Duplicated collecting system (HP:0000081)2.52759596
41Absent thumb (HP:0009777)2.51982521
42Abnormality of the carotid arteries (HP:0005344)2.48268370
43Short 4th metacarpal (HP:0010044)2.45102175
44Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.45102175
45Supernumerary spleens (HP:0009799)2.44681003
46Astrocytoma (HP:0009592)2.44258225
47Abnormality of the astrocytes (HP:0100707)2.44258225
48Oral leukoplakia (HP:0002745)2.44073856
49Embryonal renal neoplasm (HP:0011794)2.43719987
5011 pairs of ribs (HP:0000878)2.43292736
51Cafe-au-lait spot (HP:0000957)2.40742704
52Abnormal number of incisors (HP:0011064)2.38718449
53Glioma (HP:0009733)2.33783127
54Bone marrow hypocellularity (HP:0005528)2.31070426
55Missing ribs (HP:0000921)2.30437428
56Abnormality of the anterior horn cell (HP:0006802)2.26509065
57Degeneration of anterior horn cells (HP:0002398)2.26509065
58Facial hemangioma (HP:0000329)2.26449683
59Aplasia/Hypoplasia of the sternum (HP:0006714)2.26328329
60Neoplasm of the oral cavity (HP:0100649)2.24463905
61Abnormality of the renal collecting system (HP:0004742)2.24123582
62Short thumb (HP:0009778)2.23983540
63Embryonal neoplasm (HP:0002898)2.23274130
64Tracheoesophageal fistula (HP:0002575)2.22569725
65Neoplasm of the pancreas (HP:0002894)2.20888521
66Macrocytic anemia (HP:0001972)2.19570733
67Atresia of the external auditory canal (HP:0000413)2.12801571
68Basal cell carcinoma (HP:0002671)2.12622294
69Horseshoe kidney (HP:0000085)2.12174287
70Clubbing of toes (HP:0100760)2.10086921
71Microvesicular hepatic steatosis (HP:0001414)2.06948952
72Prominent nose (HP:0000448)2.06891785
73Biliary tract neoplasm (HP:0100574)2.06735843
74Progressive external ophthalmoplegia (HP:0000590)2.04559537
75Triphalangeal thumb (HP:0001199)2.04346782
76Squamous cell carcinoma (HP:0002860)2.02717367
77Abnormality of abdominal situs (HP:0011620)2.00095172
78Abdominal situs inversus (HP:0003363)2.00095172
79High pitched voice (HP:0001620)1.98481895
80Amaurosis fugax (HP:0100576)1.98210909
81Pallor (HP:0000980)1.97498191
82Overlapping toe (HP:0001845)1.96351319
83Neoplasm of the colon (HP:0100273)1.96111612
84Malignant gastrointestinal tract tumors (HP:0006749)1.95794217
85Gastrointestinal carcinoma (HP:0002672)1.95794217
86Neoplasm of striated muscle (HP:0009728)1.94584714
87Deep philtrum (HP:0002002)1.94383022
88Abnormality of DNA repair (HP:0003254)1.94366398
89Abnormality of glycolysis (HP:0004366)1.92843814
90Rough bone trabeculation (HP:0100670)1.92383677
91Premature graying of hair (HP:0002216)1.91787976
92Abnormality of cochlea (HP:0000375)1.91483061
93Aplasia/hypoplasia of the humerus (HP:0006507)1.91430321
94Skull defect (HP:0001362)1.91079792
95Progressive muscle weakness (HP:0003323)1.90392025
96Abnormality of the fetal cardiovascular system (HP:0010948)1.87232400
97Abnormal umbilical cord blood vessels (HP:0011403)1.87232400
98Single umbilical artery (HP:0001195)1.87232400
99Long eyelashes (HP:0000527)1.86974507
100Increased serum pyruvate (HP:0003542)1.85402894
101Ovarian neoplasm (HP:0100615)1.83730608
102Sandal gap (HP:0001852)1.82063294
103Abnormality of cells of the erythroid lineage (HP:0012130)1.81983033
104Abnormality of methionine metabolism (HP:0010901)1.80067744
105Abnormality of the umbilical cord (HP:0010881)1.77202931
106Duplication of thumb phalanx (HP:0009942)1.76417043
107Arteriovenous malformation (HP:0100026)1.75850880
108Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75809048
109Short middle phalanx of the 5th finger (HP:0004220)1.74980699
110Abnormality of chromosome segregation (HP:0002916)1.74667778
111Rib fusion (HP:0000902)1.74536841
112Facial cleft (HP:0002006)1.74136723
113Aplastic anemia (HP:0001915)1.73780287
114Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73638265
115Choanal atresia (HP:0000453)1.71765510
116Abnormality of reticulocytes (HP:0004312)1.71239336
117Abnormality of the calcaneus (HP:0008364)1.71160885
118Abnormal number of erythroid precursors (HP:0012131)1.70806713
119Short humerus (HP:0005792)1.70230861
120Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.69417191
121Pancreatic islet-cell hyperplasia (HP:0004510)1.67143078
122Hypoplastic pelvis (HP:0008839)1.66699306
123Megaloblastic anemia (HP:0001889)1.65917975
124Abnormality of the septum pellucidum (HP:0007375)1.64871798
125Uterine neoplasm (HP:0010784)1.62555512
126Ankyloglossia (HP:0010296)1.61880187
127Aplasia/Hypoplasia of the earlobes (HP:0009906)1.57584763
128Hypoplasia of the pons (HP:0012110)1.57237553
129Acute myeloid leukemia (HP:0004808)1.56638271
130Uterine leiomyosarcoma (HP:0002891)1.56545555
131Leiomyosarcoma (HP:0100243)1.56545555
132Reduced antithrombin III activity (HP:0001976)1.55123041
133Increased hepatocellular lipid droplets (HP:0006565)1.54590001
134Capillary hemangiomas (HP:0005306)1.54297793

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.58157493
2CDC74.52057000
3WEE14.10037057
4NEK23.80066503
5NEK13.34163986
6TTK3.10343024
7CDK122.87402507
8BRSK22.68219704
9SRPK12.50723240
10PLK12.35966053
11EIF2AK12.31263761
12PLK42.26130280
13AURKB2.11989016
14PLK32.11652755
15VRK22.00407344
16BRSK11.89291965
17ATR1.80517919
18CHEK21.72968291
19TLK11.72911326
20ZAK1.71658414
21MKNK11.68958891
22STK41.68254016
23STK101.66143254
24RPS6KB21.63190225
25CDK71.57698961
26TAF11.54855925
27EPHA21.50883112
28MAP3K81.49174283
29TSSK61.49098742
30CHEK11.48278562
31VRK11.45879220
32ACVR1B1.45257968
33EEF2K1.44732447
34CDK41.43945979
35PASK1.41610324
36AURKA1.38250958
37CCNB11.35230831
38BRD41.30481874
39MKNK21.21867208
40ATM1.19122254
41MELK1.18890207
42RPS6KA41.13848697
43STK31.13294755
44DYRK31.08839403
45CDK61.04968314
46EIF2AK31.03976890
47SMG11.01976872
48SCYL20.98691018
49CDK20.95550920
50TESK20.93439881
51EIF2AK20.90341481
52TNIK0.89341936
53LATS10.87762609
54PBK0.87716687
55CDK10.85870664
56PIM10.82299273
57STK38L0.78791794
58PKN20.78751209
59ERBB40.77278700
60PAK40.76212373
61NME10.75989548
62ALK0.73394597
63TRIM280.72580353
64NME20.72450212
65MST1R0.70972006
66MAP3K100.70480212
67FLT30.63977199
68TGFBR10.59197083
69CLK10.58387248
70PNCK0.56894214
71MARK30.55639688
72PAK10.54851169
73MTOR0.54484920
74CSNK2A20.53868709
75RPS6KA50.51355646
76CSNK2A10.50399906
77STK160.47769248
78MAP3K90.47711063
79PRKDC0.47096942
80PRKCI0.45444791
81AKT20.41616351
82CSNK1D0.40816254
83BRAF0.40687571
84PLK20.40259946
85MET0.39870057
86TTN0.39431099
87PDK20.39021785
88MAPK140.38405745
89CDK30.36871421
90AKT30.36330525
91CDK80.35483735
92LATS20.34592331
93CDK180.34336129
94CDK150.33803219
95CDK90.32860420
96CDK11A0.32506751
97FGFR10.31635146
98AKT10.31404217
99CSNK1E0.31367994
100NUAK10.29787291
101RAF10.29352352
102PAK20.28872975
103YES10.28653741
104LRRK20.27262279
105CDK140.26930651
106MAPK10.26030859
107GSK3B0.24835208
108STK240.23830093
109DMPK0.21680010
110NEK60.19529363
111TESK10.19398078
112MAPKAPK20.18835723
113BCR0.18427922
114CAMK1G0.18016868
115PDGFRA0.17951348
116NTRK20.16841459
117MAPK110.16655686
118CHUK0.16265018
119NEK90.15658260
120MST40.15181016
121TRPM70.15036728
122RPS6KB10.14646127
123TEC0.12757450
124ERBB20.12265561
125RPS6KA10.11401362

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.61183236
2Mismatch repair_Homo sapiens_hsa034304.21177793
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.56388787
4Cell cycle_Homo sapiens_hsa041103.46502389
5RNA transport_Homo sapiens_hsa030133.29960887
6Homologous recombination_Homo sapiens_hsa034403.23176613
7Spliceosome_Homo sapiens_hsa030403.19728584
8Base excision repair_Homo sapiens_hsa034102.98210629
9Fanconi anemia pathway_Homo sapiens_hsa034602.90800427
10One carbon pool by folate_Homo sapiens_hsa006702.85372377
11Nucleotide excision repair_Homo sapiens_hsa034202.82197260
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.59050108
13RNA polymerase_Homo sapiens_hsa030202.50079326
14Non-homologous end-joining_Homo sapiens_hsa034502.42571412
15Ribosome_Homo sapiens_hsa030102.20034496
16Systemic lupus erythematosus_Homo sapiens_hsa053222.15634277
17mRNA surveillance pathway_Homo sapiens_hsa030152.15152288
18p53 signaling pathway_Homo sapiens_hsa041152.05950938
19RNA degradation_Homo sapiens_hsa030181.99695149
20Pyrimidine metabolism_Homo sapiens_hsa002401.97250768
21Basal transcription factors_Homo sapiens_hsa030221.94497963
22Proteasome_Homo sapiens_hsa030501.88487755
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.69744838
24Pyruvate metabolism_Homo sapiens_hsa006201.46798182
25Oocyte meiosis_Homo sapiens_hsa041141.40796359
26Viral carcinogenesis_Homo sapiens_hsa052031.39390528
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.38909579
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38706850
29Protein export_Homo sapiens_hsa030601.27856595
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19592000
31Epstein-Barr virus infection_Homo sapiens_hsa051691.19304620
32MicroRNAs in cancer_Homo sapiens_hsa052061.15932633
33Herpes simplex infection_Homo sapiens_hsa051681.03399074
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02976461
35Purine metabolism_Homo sapiens_hsa002301.02048574
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95439680
37HTLV-I infection_Homo sapiens_hsa051660.95366143
38Small cell lung cancer_Homo sapiens_hsa052220.94253780
39Alcoholism_Homo sapiens_hsa050340.93005010
40Antigen processing and presentation_Homo sapiens_hsa046120.88546693
41Steroid biosynthesis_Homo sapiens_hsa001000.87284956
42Parkinsons disease_Homo sapiens_hsa050120.79909921
43Huntingtons disease_Homo sapiens_hsa050160.78490564
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78207022
45Vitamin B6 metabolism_Homo sapiens_hsa007500.77772396
46Selenocompound metabolism_Homo sapiens_hsa004500.75334999
47Propanoate metabolism_Homo sapiens_hsa006400.74213238
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72785158
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71758144
50Hippo signaling pathway_Homo sapiens_hsa043900.70955679
51Basal cell carcinoma_Homo sapiens_hsa052170.69400518
52TGF-beta signaling pathway_Homo sapiens_hsa043500.69178565
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67460356
54Thyroid cancer_Homo sapiens_hsa052160.66448533
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65418270
56Pentose phosphate pathway_Homo sapiens_hsa000300.64103640
57Adherens junction_Homo sapiens_hsa045200.64068451
58Colorectal cancer_Homo sapiens_hsa052100.61414630
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61066945
60Oxidative phosphorylation_Homo sapiens_hsa001900.59057739
61Biosynthesis of amino acids_Homo sapiens_hsa012300.58610675
62Apoptosis_Homo sapiens_hsa042100.55344571
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54671098
64Notch signaling pathway_Homo sapiens_hsa043300.51945239
65Sulfur relay system_Homo sapiens_hsa041220.51543973
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51310541
67Chronic myeloid leukemia_Homo sapiens_hsa052200.51292626
68Hepatitis B_Homo sapiens_hsa051610.49287545
69Lysine degradation_Homo sapiens_hsa003100.48312865
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48280510
71Fatty acid elongation_Homo sapiens_hsa000620.47850778
72Legionellosis_Homo sapiens_hsa051340.47542012
73Bladder cancer_Homo sapiens_hsa052190.47239383
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.45518374
75Prostate cancer_Homo sapiens_hsa052150.43405075
76Pathways in cancer_Homo sapiens_hsa052000.42977183
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.42819126
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42160583
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.41506077
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.39063632
81Viral myocarditis_Homo sapiens_hsa054160.38738553
82Hedgehog signaling pathway_Homo sapiens_hsa043400.37967499
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37335804
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37157011
85Olfactory transduction_Homo sapiens_hsa047400.36720892
86Primary immunodeficiency_Homo sapiens_hsa053400.36367136
87Measles_Homo sapiens_hsa051620.36229324
88FoxO signaling pathway_Homo sapiens_hsa040680.35366288
89mTOR signaling pathway_Homo sapiens_hsa041500.35079039
90Influenza A_Homo sapiens_hsa051640.34590475
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34165857
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34095852
93HIF-1 signaling pathway_Homo sapiens_hsa040660.33725800
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33138599
95Sulfur metabolism_Homo sapiens_hsa009200.32521402
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.31981777
97Hematopoietic cell lineage_Homo sapiens_hsa046400.31646120
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30852280
99Pancreatic cancer_Homo sapiens_hsa052120.30715010
100Melanoma_Homo sapiens_hsa052180.29117496
101Tight junction_Homo sapiens_hsa045300.28805087
102Proteoglycans in cancer_Homo sapiens_hsa052050.28753425
103Metabolic pathways_Homo sapiens_hsa011000.28425977
104Shigellosis_Homo sapiens_hsa051310.27605479
105Non-small cell lung cancer_Homo sapiens_hsa052230.26995782
106Alzheimers disease_Homo sapiens_hsa050100.24588123
107Wnt signaling pathway_Homo sapiens_hsa043100.23974230
108Glutathione metabolism_Homo sapiens_hsa004800.23655153
109Fatty acid metabolism_Homo sapiens_hsa012120.23105911
110Endometrial cancer_Homo sapiens_hsa052130.22176219
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.21033563
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21010497
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.20953114
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20578627
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20140779
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18779519
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18437177
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18376580
119Carbon metabolism_Homo sapiens_hsa012000.17674498
120N-Glycan biosynthesis_Homo sapiens_hsa005100.17436192
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16852666
122Vitamin digestion and absorption_Homo sapiens_hsa049770.15390341
123Renin-angiotensin system_Homo sapiens_hsa046140.14656367
124Folate biosynthesis_Homo sapiens_hsa007900.13827922
125Acute myeloid leukemia_Homo sapiens_hsa052210.12303827
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11289372
127Gap junction_Homo sapiens_hsa045400.11167504
128Galactose metabolism_Homo sapiens_hsa000520.10015802
129Focal adhesion_Homo sapiens_hsa045100.09995152
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08739658
131Arginine and proline metabolism_Homo sapiens_hsa003300.08689143

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