HMOX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.32754486
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.32754486
3modulation by symbiont of host immune response (GO:0052553)6.32754486
4positive regulation by symbiont of host defense response (GO:0052509)6.32754486
5modulation by symbiont of host defense response (GO:0052031)6.32754486
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.32754486
7response to peptidoglycan (GO:0032494)5.06452668
8regulation of interferon-beta biosynthetic process (GO:0045357)4.65190928
9glycosphingolipid catabolic process (GO:0046479)4.63905814
10macrophage activation involved in immune response (GO:0002281)4.61099783
11neutrophil activation involved in immune response (GO:0002283)4.60605611
12positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.57334382
13positive regulation of interferon-alpha production (GO:0032727)4.47810304
14amino sugar catabolic process (GO:0046348)4.47638431
15cellular response to thyroid hormone stimulus (GO:0097067)4.42464261
16regulation of interferon-alpha production (GO:0032647)4.35977808
17oligosaccharide catabolic process (GO:0009313)4.16479505
18glycolipid catabolic process (GO:0019377)4.15797991
19respiratory burst (GO:0045730)4.01026874
20positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.99072802
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.93189952
22response to host immune response (GO:0052572)3.93189952
23immunoglobulin mediated immune response (GO:0016064)3.91471480
24regulation of mononuclear cell migration (GO:0071675)3.90625284
25N-acetylneuraminate metabolic process (GO:0006054)3.86473822
26lipopolysaccharide-mediated signaling pathway (GO:0031663)3.84226994
27response to muramyl dipeptide (GO:0032495)3.76069138
28wound healing, spreading of epidermal cells (GO:0035313)3.75529795
29positive regulation of heat generation (GO:0031652)3.75528219
30* positive regulation of chemokine biosynthetic process (GO:0045080)3.73215877
31regulation of dendritic cell antigen processing and presentation (GO:0002604)3.71434926
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.68414266
33negative regulation of interleukin-12 production (GO:0032695)3.67644002
34ceramide catabolic process (GO:0046514)3.64767788
35protein localization to endosome (GO:0036010)3.62114657
36hydrogen peroxide biosynthetic process (GO:0050665)3.59500005
37response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.58166475
38response to host (GO:0075136)3.58166475
39response to host defenses (GO:0052200)3.58166475
40response to thyroid hormone (GO:0097066)3.58152190
41regulation of fever generation (GO:0031620)3.58141383
42barbed-end actin filament capping (GO:0051016)3.57476368
43regulation of cholesterol storage (GO:0010885)3.52556211
44regulation of macrophage chemotaxis (GO:0010758)3.52357635
45regulation of podosome assembly (GO:0071801)3.50653506
46regulation of membrane protein ectodomain proteolysis (GO:0051043)3.50234457
47positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.43908763
48microglial cell activation (GO:0001774)3.35565538
49negative regulation of erythrocyte differentiation (GO:0045647)3.34399487
50positive regulation of monocyte chemotaxis (GO:0090026)3.31400879
51macrophage activation (GO:0042116)3.30308828
52membrane lipid catabolic process (GO:0046466)3.26861085
53T-helper 1 type immune response (GO:0042088)3.24939487
54granulocyte activation (GO:0036230)3.22564977
55apoptotic cell clearance (GO:0043277)3.21693954
56negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.19936471
57positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.19436227
58cell adhesion mediated by integrin (GO:0033627)3.17028739
59detection of other organism (GO:0098543)3.16451438
60regulation of interleukin-8 biosynthetic process (GO:0045414)3.16398360
61positive regulation of antigen processing and presentation (GO:0002579)3.15286438
62positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.14626454
63positive regulation of cellular amide metabolic process (GO:0034250)3.12260742
64sphingolipid catabolic process (GO:0030149)3.11633457
65positive regulation of interferon-beta production (GO:0032728)3.11399112
66regulation of heterotypic cell-cell adhesion (GO:0034114)3.09475641
67detection of molecule of bacterial origin (GO:0032490)3.08140387
68reactive oxygen species biosynthetic process (GO:1903409)3.07414506
69regulation of monocyte chemotaxis (GO:0090025)3.06913250
70detection of external biotic stimulus (GO:0098581)3.06157256
71* regulation of mast cell degranulation (GO:0043304)3.03099767
72* low-density lipoprotein particle clearance (GO:0034383)3.02839859
73regulation of antigen processing and presentation (GO:0002577)2.98519052
74natural killer cell mediated immunity (GO:0002228)2.96537074
75natural killer cell mediated cytotoxicity (GO:0042267)2.96537074
76positive regulation of p38MAPK cascade (GO:1900745)2.96357607
77negative regulation of lipid storage (GO:0010888)2.94916557
78B cell mediated immunity (GO:0019724)2.94755527
79positive regulation of cholesterol efflux (GO:0010875)2.93586549
80hyaluronan catabolic process (GO:0030214)2.92581709
81myeloid cell activation involved in immune response (GO:0002275)2.92260316
82* regulation of leukocyte degranulation (GO:0043300)2.90990801
83positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.90217734
84wound healing, spreading of cells (GO:0044319)2.90149354
85cellular extravasation (GO:0045123)2.89533424
86chronic inflammatory response (GO:0002544)2.88250787
87leukocyte aggregation (GO:0070486)2.87725494
88superoxide anion generation (GO:0042554)2.87519757
89detection of bacterium (GO:0016045)2.87297111
90regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.86095480
91adenosine receptor signaling pathway (GO:0001973)2.85565437
92virion attachment to host cell (GO:0019062)2.85431958
93adhesion of symbiont to host cell (GO:0044650)2.85431958
94negative regulation of nitric oxide biosynthetic process (GO:0045019)2.83599055
95neutrophil activation (GO:0042119)2.83351476
96positive regulation of extracellular matrix organization (GO:1903055)2.82711327
97response to laminar fluid shear stress (GO:0034616)2.80798927
98positive regulation of gamma-delta T cell activation (GO:0046645)2.80752096
99regulation of early endosome to late endosome transport (GO:2000641)2.79805105
100positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.79431749
101mannose metabolic process (GO:0006013)2.78299862
102peptide catabolic process (GO:0043171)2.77698274
103regulation of superoxide anion generation (GO:0032928)2.77617665
104regulation of heat generation (GO:0031650)2.76867675
105regulation of vitamin D biosynthetic process (GO:0060556)2.76259893
106regulation of macrophage cytokine production (GO:0010935)2.75109907
107positive regulation of NF-kappaB import into nucleus (GO:0042346)2.73575955
108myeloid dendritic cell differentiation (GO:0043011)2.73495221
109macrophage differentiation (GO:0030225)2.72714765
110negative regulation of cell killing (GO:0031342)2.72384865
111negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.72384865
112monocyte chemotaxis (GO:0002548)2.71869576
113negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.70977048
114* regulation of mast cell activation involved in immune response (GO:0033006)2.70930183
115negative regulation of interleukin-6 production (GO:0032715)2.70480202
116positive regulation of leukocyte degranulation (GO:0043302)2.70228578
117eosinophil chemotaxis (GO:0048245)2.68195594
118positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.67961310
119I-kappaB phosphorylation (GO:0007252)2.67505877
120* regulation of chemokine biosynthetic process (GO:0045073)2.66919774
121pinocytosis (GO:0006907)2.66545942
122detection of biotic stimulus (GO:0009595)2.65529037
123neutrophil chemotaxis (GO:0030593)2.63186275
124eosinophil migration (GO:0072677)2.63102899
125cellular response to interferon-alpha (GO:0035457)2.62255435
126leukocyte cell-cell adhesion (GO:0007159)2.61505765
127positive regulation of mast cell activation (GO:0033005)2.61164256
128decidualization (GO:0046697)2.61163115
129Arp2/3 complex-mediated actin nucleation (GO:0034314)2.61052501
130NIK/NF-kappaB signaling (GO:0038061)2.60813017
131regulation of integrin activation (GO:0033623)2.60451414
132positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.60266184
133* regulation of myeloid leukocyte mediated immunity (GO:0002886)2.59953777
134phagosome maturation (GO:0090382)2.59793551
135* positive regulation of chemokine production (GO:0032722)2.59322405
136positive regulation of leukocyte apoptotic process (GO:2000108)2.58555104
137positive regulation of interleukin-6 production (GO:0032755)2.57477058
138adhesion of symbiont to host (GO:0044406)2.57077059
139positive regulation of mast cell activation involved in immune response (GO:0033008)2.56868524
140positive regulation of mast cell degranulation (GO:0043306)2.56868524
141stress fiber assembly (GO:0043149)2.56810105
142positive regulation of lipid storage (GO:0010884)2.56606788
143positive regulation of receptor recycling (GO:0001921)2.56400297
144* myeloid cell homeostasis (GO:0002262)2.56003004
145germinal center formation (GO:0002467)2.55736708
146neutrophil migration (GO:1990266)2.55725392
147negative regulation of granulocyte differentiation (GO:0030853)2.54389476
148L-alpha-amino acid transmembrane transport (GO:1902475)2.54095436
149antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.53726616
150antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.53726616
151regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.53472828
152regulation of T-helper 2 cell differentiation (GO:0045628)2.52356241
153keratan sulfate catabolic process (GO:0042340)2.51881718
154cellular response to lipopolysaccharide (GO:0071222)2.51212824
155regulation of T cell tolerance induction (GO:0002664)2.47270077
156regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.44718350
157modulation by symbiont of host cellular process (GO:0044068)2.44351429
158response to acidic pH (GO:0010447)2.42010286
159lytic vacuole organization (GO:0080171)2.40810401
160lysosome organization (GO:0007040)2.40810401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_21731497_ChIP-ChIP_J774_Mouse5.30974033
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.18927514
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.50420472
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.42022289
5* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.65056364
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.49925838
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.49286627
8* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.45460260
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.35556452
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.33333704
11* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.20682185
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.96905535
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.66510879
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.54599287
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.54302266
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.51434542
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.44439515
18BRD4_27068464_Chip-Seq_AML-cells_Mouse2.23479981
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21582200
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.98354137
21* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97935922
22* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.92508975
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.91661841
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88218456
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85591758
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.85324888
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.83449726
28* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.78453568
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.78192277
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.72487072
31SPI1_23547873_ChIP-Seq_NB4_Human1.69404121
32PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.65449968
33CLOCK_20551151_ChIP-Seq_293T_Human1.64414406
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62491751
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61855047
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59863486
37RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.58957170
38GATA1_19941826_ChIP-Seq_K562_Human1.57624390
39VDR_24763502_ChIP-Seq_THP-1_Human1.54709549
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.53532526
41CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52298064
42SCL_19346495_ChIP-Seq_HPC-7_Human1.49237830
43* TFEB_21752829_ChIP-Seq_HELA_Human1.49157460
44ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.48910695
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48552726
46SPI1_23127762_ChIP-Seq_K562_Human1.48538384
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.46815661
48SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44652698
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44578402
50MAF_26560356_Chip-Seq_TH1_Human1.44382969
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43515015
52CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42594352
53VDR_21846776_ChIP-Seq_THP-1_Human1.38534406
54PU_27001747_Chip-Seq_BMDM_Mouse1.37695274
55FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.37679320
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37092391
57SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36255935
58SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36255935
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.36120404
60VDR_24787735_ChIP-Seq_THP-1_Human1.32938407
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31354425
62RXR_22158963_ChIP-Seq_LIVER_Mouse1.29347280
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28326268
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.27017178
65KDM2B_26808549_Chip-Seq_K562_Human1.26781655
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26616009
67ATF3_27146783_Chip-Seq_COLON_Human1.25089802
68MYB_26560356_Chip-Seq_TH2_Human1.22926185
69* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22107456
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21371585
71* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20249296
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20240339
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13891094
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12275765
75MYC_22102868_ChIP-Seq_BL_Human1.12235187
76* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12231375
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11130440
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10904292
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09918894
80* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08974894
81* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08974894
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08668660
83* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08652110
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08447148
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07341131
86* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06737870
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06672885
88* TCF7_22412390_ChIP-Seq_EML_Mouse1.06431210
89* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06200394
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04441157
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04126715
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.03491104
93BCOR_27268052_Chip-Seq_Bcells_Human1.03449449
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03336784
95FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02525436
96* CJUN_26792858_Chip-Seq_BT549_Human1.02017419
97* UTX_26944678_Chip-Seq_JUKART_Human1.01872278
98TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01848607
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01596132
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01447890
101MAF_26560356_Chip-Seq_TH2_Human1.01267536
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01117351
103LXR_22292898_ChIP-Seq_THP-1_Human1.01036932
104KDM2B_26808549_Chip-Seq_DND41_Human1.00670819
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99834270
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99831028
107SOX2_20726797_ChIP-Seq_SW620_Human0.99043622
108GATA2_19941826_ChIP-Seq_K562_Human0.97395793
109LXR_22158963_ChIP-Seq_LIVER_Mouse0.97042791
110P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96654510
111ESR1_21235772_ChIP-Seq_MCF-7_Human0.96551884
112BCL6_27268052_Chip-Seq_Bcells_Human0.96248267
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96137969
114PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96037188
115PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95988070
116P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95796876
117* MYB_26560356_Chip-Seq_TH1_Human0.95739953
118RACK7_27058665_Chip-Seq_MCF-7_Human0.95651221
119RUNX_20019798_ChIP-Seq_JUKART_Human0.95528817
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94785309
121ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93801367
122* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93550654
123PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93388157
124SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92706486
125FOXO3_23340844_ChIP-Seq_DLD1_Human0.91505096
126EGR1_19032775_ChIP-ChIP_M12_Human0.90932144
127* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90252817
128KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90158886
129* NCOR1_26117541_ChIP-Seq_K562_Human0.88227780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.08041096
2MP0003436_decreased_susceptibility_to3.54139872
3MP0005058_abnormal_lysosome_morphology3.19140154
4MP0006082_CNS_inflammation2.76683071
5MP0002419_abnormal_innate_immunity2.74738639
6MP0008438_abnormal_cutaneous_collagen2.71569461
7MP0001835_abnormal_antigen_presentation2.65781960
8MP0004510_myositis2.62398592
9MP0003705_abnormal_hypodermis_morpholog2.58103196
10* MP0009785_altered_susceptibility_to2.55032806
11MP0010352_gastrointestinal_tract_polyps2.41164415
12MP0001533_abnormal_skeleton_physiology2.40846721
13MP0002139_abnormal_hepatobiliary_system2.40762920
14* MP0005000_abnormal_immune_tolerance2.35615085
15MP0003724_increased_susceptibility_to2.30984075
16MP0004947_skin_inflammation2.27113294
17MP0002148_abnormal_hypersensitivity_rea2.18810800
18* MP0005025_abnormal_response_to2.12018657
19MP0003566_abnormal_cell_adhesion2.09544130
20MP0003172_abnormal_lysosome_physiology2.04477136
21MP0003448_altered_tumor_morphology2.02503378
22MP0009840_abnormal_foam_cell2.00465971
23MP0002452_abnormal_antigen_presenting2.00117784
24MP0005451_abnormal_body_composition1.95201808
25MP0001790_abnormal_immune_system1.92891800
26MP0005387_immune_system_phenotype1.92891800
27MP0009278_abnormal_bone_marrow1.90688970
28* MP0000343_altered_response_to1.84850430
29MP0005023_abnormal_wound_healing1.82491989
30MP0005464_abnormal_platelet_physiology1.80630233
31MP0001853_heart_inflammation1.76934908
32MP0008260_abnormal_autophagy1.76343707
33MP0003300_gastrointestinal_ulcer1.74830074
34* MP0002723_abnormal_immune_serum1.70603654
35MP0002998_abnormal_bone_remodeling1.70086503
36MP0003191_abnormal_cellular_cholesterol1.69549643
37MP0000604_amyloidosis1.67818773
38MP0005257_abnormal_intraocular_pressure1.66709121
39MP0003075_altered_response_to1.64617849
40MP0001800_abnormal_humoral_immune1.63435731
41MP0000685_abnormal_immune_system1.59013267
42* MP0002405_respiratory_system_inflammati1.57899497
43MP0000858_altered_metastatic_potential1.56961621
44* MP0001845_abnormal_inflammatory_respons1.55364933
45MP0005164_abnormal_response_to1.54051266
46MP0001958_emphysema1.53457911
47MP0005076_abnormal_cell_differentiation1.52699976
48MP0001819_abnormal_immune_cell1.52510615
49MP0010307_abnormal_tumor_latency1.51654020
50MP0009764_decreased_sensitivity_to1.51084024
51MP0002420_abnormal_adaptive_immunity1.50460288
52MP0003091_abnormal_cell_migration1.47042857
53MP0005390_skeleton_phenotype1.40442771
54MP0003453_abnormal_keratinocyte_physiol1.39005831
55MP0003279_aneurysm1.36774508
56MP0003329_amyloid_beta_deposits1.35509184
57MP0002933_joint_inflammation1.35112443
58* MP0008469_abnormal_protein_level1.34643817
59MP0004858_abnormal_nervous_system1.34263973
60MP0005275_abnormal_skin_tensile1.28429070
61MP0005671_abnormal_response_to1.28237055
62MP0002254_reproductive_system_inflammat1.23915420
63MP0005397_hematopoietic_system_phenotyp1.20328930
64MP0001545_abnormal_hematopoietic_system1.20328930
65MP0010155_abnormal_intestine_physiology1.18907607
66* MP0003186_abnormal_redox_activity1.17881771
67MP0002877_abnormal_melanocyte_morpholog1.16377411
68MP0005166_decreased_susceptibility_to1.15516703
69MP0001851_eye_inflammation1.15432847
70MP0008004_abnormal_stomach_pH1.08850835
71MP0003828_pulmonary_edema1.08667182
72MP0002138_abnormal_hepatobiliary_system1.07287822
73* MP0009333_abnormal_splenocyte_physiolog1.05973136
74MP0000920_abnormal_myelination1.05028556
75MP0003656_abnormal_erythrocyte_physiolo1.01169543
76MP0005365_abnormal_bile_salt0.98977647
77MP0000465_gastrointestinal_hemorrhage0.98652694
78* MP0000716_abnormal_immune_system0.97724408
79MP0003795_abnormal_bone_structure0.96854817
80MP0002295_abnormal_pulmonary_circulatio0.95080109
81MP0000249_abnormal_blood_vessel0.94648626
82MP0000750_abnormal_muscle_regeneration0.89880101
83MP0009763_increased_sensitivity_to0.89086679
84MP0002398_abnormal_bone_marrow0.88992924
85* MP0000689_abnormal_spleen_morphology0.88868240
86MP0000569_abnormal_digit_pigmentation0.88493281
87MP0004272_abnormal_basement_membrane0.87493240
88MP0000767_abnormal_smooth_muscle0.87279497
89MP0004883_abnormal_blood_vessel0.86596864
90MP0001542_abnormal_bone_strength0.85501410
91MP0003806_abnormal_nucleotide_metabolis0.84381583
92MP0005167_abnormal_blood-brain_barrier0.83726078
93* MP0002429_abnormal_blood_cell0.83321648
94MP0001243_abnormal_dermal_layer0.83073252
95MP0003183_abnormal_peptide_metabolism0.81553325
96MP0002006_tumorigenesis0.81285784
97MP0003690_abnormal_glial_cell0.80759207
98* MP0002722_abnormal_immune_system0.80353737
99MP0006054_spinal_hemorrhage0.80242489
100MP0005310_abnormal_salivary_gland0.79285108
101MP0003634_abnormal_glial_cell0.79191205
102MP0003195_calcinosis0.79069078
103MP0000733_abnormal_muscle_development0.78331448
104MP0002796_impaired_skin_barrier0.77499673
105MP0005165_increased_susceptibility_to0.75328613
106MP0003045_fibrosis0.74882177
107MP0001849_ear_inflammation0.71089957
108* MP0005595_abnormal_vascular_smooth0.71038770
109MP0002896_abnormal_bone_mineralization0.70944880
110MP0000371_diluted_coat_color0.70122109
111MP0004808_abnormal_hematopoietic_stem0.68875108
112MP0005197_abnormal_uvea_morphology0.66744413
113MP0005503_abnormal_tendon_morphology0.66567592
114MP0001915_intracranial_hemorrhage0.66238626
115MP0002332_abnormal_exercise_endurance0.65757234
116MP0005319_abnormal_enzyme/_coenzyme0.64992389
117MP0001663_abnormal_digestive_system0.62757330
118* MP0000609_abnormal_liver_physiology0.62712049

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.58306956
2Recurrent abscess formation (HP:0002722)5.52993261
3Recurrent gram-negative bacterial infections (HP:0005420)5.07760177
4Increased cerebral lipofuscin (HP:0011813)5.05616901
5Recurrent bacterial skin infections (HP:0005406)4.70858739
6Abnormality of macrophages (HP:0004311)4.56456741
7Increased neuronal autofluorescent lipopigment (HP:0002074)4.40903065
8Vacuolated lymphocytes (HP:0001922)4.11453805
9Systemic lupus erythematosus (HP:0002725)4.07582488
10Vertebral compression fractures (HP:0002953)3.94777022
11Orchitis (HP:0100796)3.90664363
12Elevated erythrocyte sedimentation rate (HP:0003565)3.89999975
13Stomatitis (HP:0010280)3.70615633
14Myositis (HP:0100614)3.64745338
15Mediastinal lymphadenopathy (HP:0100721)3.64236467
16Peritonitis (HP:0002586)3.62034521
17Neurofibrillary tangles (HP:0002185)3.53250422
18Nuclear cataract (HP:0100018)3.52521818
19Dysostosis multiplex (HP:0000943)3.49511165
20Tetraparesis (HP:0002273)3.43807100
21Axonal loss (HP:0003447)3.43292227
22Mutism (HP:0002300)3.43119097
23Autoimmune thrombocytopenia (HP:0001973)3.24929862
24Retrobulbar optic neuritis (HP:0100654)3.24619897
25Optic neuritis (HP:0100653)3.24619897
26Abnormality of liposaccharide metabolism (HP:0010968)3.18037403
27Abnormality of glycosphingolipid metabolism (HP:0004343)3.18037403
28Abnormality of glycolipid metabolism (HP:0010969)3.18037403
29Interstitial pulmonary disease (HP:0006530)3.17469069
30Gingivitis (HP:0000230)3.16415382
31Myocardial infarction (HP:0001658)3.14969968
32Urinary glycosaminoglycan excretion (HP:0003541)3.06956596
33Mucopolysacchariduria (HP:0008155)3.06956596
34Premature rupture of membranes (HP:0001788)3.02577076
35Protrusio acetabuli (HP:0003179)2.93489861
36Disinhibition (HP:0000734)2.89078799
37Abnormality of polysaccharide metabolism (HP:0011012)2.88059203
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.88059203
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.88059203
40Chronic obstructive pulmonary disease (HP:0006510)2.86656830
41Obstructive lung disease (HP:0006536)2.86656830
42Cerebral inclusion bodies (HP:0100314)2.79729144
43Purpura (HP:0000979)2.79025893
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.71845113
45Complement deficiency (HP:0004431)2.70584925
46Cervical subluxation (HP:0003308)2.63417432
47Glomerulonephritis (HP:0000099)2.60356218
48Recurrent skin infections (HP:0001581)2.60005768
49Urticaria (HP:0001025)2.58770528
50Cerebral aneurysm (HP:0004944)2.58657883
51Cellulitis (HP:0100658)2.53170430
52Apathy (HP:0000741)2.47769422
53Neuronal loss in central nervous system (HP:0002529)2.45353228
54Diminished motivation (HP:0000745)2.44676076
55Loss of speech (HP:0002371)2.43402837
56Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.42137834
57Pustule (HP:0200039)2.39198555
58Hematochezia (HP:0002573)2.36218501
59Osteolytic defects of the phalanges of the hand (HP:0009771)2.34641175
60Osteolytic defects of the hand bones (HP:0009699)2.34641175
61Vasculitis (HP:0002633)2.29423625
62Pulmonary infiltrates (HP:0002113)2.27342670
63Progressive neurologic deterioration (HP:0002344)2.26040107
64Abnormality of proline metabolism (HP:0010907)2.24222339
65Hydroxyprolinuria (HP:0003080)2.24222339
66Recurrent fungal infections (HP:0002841)2.23918066
67Thick nail (HP:0001805)2.20667238
68Amyloidosis (HP:0011034)2.16524551
69Nausea (HP:0002018)2.16375458
70Retinal atrophy (HP:0001105)2.14653769
71Polycythemia (HP:0001901)2.14339331
72Nephritis (HP:0000123)2.13436796
73Arterial thrombosis (HP:0004420)2.12943867
74Prolonged neonatal jaundice (HP:0006579)2.12475871
75Prostate neoplasm (HP:0100787)2.10242271
76Abnormality of the vasculature of the conjunctiva (HP:0008054)2.08000711
77Pathologic fracture (HP:0002756)2.06085982
78Supranuclear gaze palsy (HP:0000605)2.05039894
79Leukocytosis (HP:0001974)2.04252431
80Dilatation of the ascending aorta (HP:0005111)2.04245876
81Abnormality of complement system (HP:0005339)2.04004373
82Bone pain (HP:0002653)2.02685182
83Abnormality of the pericardium (HP:0001697)2.00361401
84Thoracic kyphosis (HP:0002942)2.00277546
85Dementia (HP:0000726)1.99932137
86Osteomyelitis (HP:0002754)1.98794719
87Increased density of long bones (HP:0006392)1.98783278
88Progressive visual loss (HP:0000529)1.97696724
89Increased serum ferritin (HP:0003281)1.95800538
90Abnormality of the nasal mucosa (HP:0000433)1.95498753
91Basal ganglia calcification (HP:0002135)1.94642012
92Ulnar bowing (HP:0003031)1.94548684
93Aortic aneurysm (HP:0004942)1.93913893
94Inappropriate behavior (HP:0000719)1.93496772
95Conjunctival telangiectasia (HP:0000524)1.93410027
96Cardiomegaly (HP:0001640)1.92808747
97Increased IgE level (HP:0003212)1.91161007
98Peripheral demyelination (HP:0011096)1.90747253
99Hepatosplenomegaly (HP:0001433)1.90036392
100Personality changes (HP:0000751)1.89787547
101Aortic dissection (HP:0002647)1.88513839
102Abnormality of the peritoneum (HP:0002585)1.88203479
103Joint stiffness (HP:0001387)1.87167505
104Abnormality of iron homeostasis (HP:0011031)1.86727407
105Upper limb amyotrophy (HP:0009129)1.86122132
106Distal upper limb amyotrophy (HP:0007149)1.86122132
107Global brain atrophy (HP:0002283)1.85644347
108Metaphyseal irregularity (HP:0003025)1.85322296
109Asymmetric septal hypertrophy (HP:0001670)1.85276751
110Emphysema (HP:0002097)1.85226732
111Spondylolisthesis (HP:0003302)1.85217775
112Malnutrition (HP:0004395)1.84064054
113Petechiae (HP:0000967)1.82962585
114Esophageal varix (HP:0002040)1.82957820
115Keratoconjunctivitis sicca (HP:0001097)1.82351426
116Spontaneous hematomas (HP:0007420)1.81663032
117Achilles tendon contracture (HP:0001771)1.79784192
118Periodontitis (HP:0000704)1.79724986
119Xanthomatosis (HP:0000991)1.78954807
120Upper motor neuron abnormality (HP:0002127)1.78425835
121Agnosia (HP:0010524)1.78388733
122Poor head control (HP:0002421)1.77790098
123Segmental peripheral demyelination/remyelination (HP:0003481)1.77706366
124Hand muscle atrophy (HP:0009130)1.77590218
125Anorexia (HP:0002039)1.76874811
126Recurrent viral infections (HP:0004429)1.76635946
127Mucosal telangiectasiae (HP:0100579)1.75392295
128Increased CSF protein (HP:0002922)1.75204081
129Distal lower limb muscle weakness (HP:0009053)1.74923233
130Fused cervical vertebrae (HP:0002949)1.74035434
131Episodic fever (HP:0001954)1.71598507
132Acrocyanosis (HP:0001063)1.68641212
133Restrictive lung disease (HP:0002091)1.67790382
134Hemoptysis (HP:0002105)1.66258751
135Ovoid vertebral bodies (HP:0003300)1.64511860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.00223483
2TBK13.86829753
3BLK3.03250271
4PBK2.94219600
5IRAK32.72832557
6MAP3K142.66039125
7PRPF4B2.59837045
8RIPK42.36122345
9TRIB32.27985178
10PIM22.23034683
11TESK12.16447339
12TYK22.13324706
13IKBKB2.06372898
14BMX2.00087086
15EPHB11.98616719
16GRK71.96044130
17STK101.81440837
18KIT1.80856562
19IRAK41.79942797
20RPS6KA41.75758985
21IKBKE1.69837014
22MAP3K31.62756739
23MAP3K111.60597586
24NME21.58590587
25TTN1.52434738
26PKN21.50619713
27TGFBR21.45570814
28CDC42BPA1.42075645
29ABL21.40736782
30ERBB41.40221340
31CSK1.38099181
32MAP4K11.36186403
33LRRK21.33707800
34MAP2K31.30802092
35JAK31.30064949
36TIE11.29421139
37FGR1.24208100
38LIMK11.21147564
39ACVR1B1.20238610
40JAK11.19829262
41EPHA31.18438855
42CHUK1.16009305
43PTK61.15926263
44SCYL21.15652550
45HCK1.13025664
46CSF1R1.10827097
47MARK31.09550828
48DDR21.09202755
49MOS1.09166322
50TESK21.08361005
51KSR21.06689147
52ICK1.04733810
53PIM11.03215748
54TAOK21.02273526
55PAK41.01819364
56MST1R0.99270310
57ZAP700.97602693
58RIPK10.92681441
59TAOK10.90891587
60CAMKK20.89366428
61PRKG20.86979942
62KDR0.82625940
63EPHB20.82295339
64FGFR40.81744678
65MAP3K50.79011847
66TRPM70.78277418
67SIK30.78184052
68EGFR0.77597350
69MAP3K10.77359758
70MATK0.76410834
71IRAK20.76288890
72PRKD20.75957794
73PDPK10.75488058
74ALK0.75425683
75LYN0.74579754
76MAP3K80.73036249
77PIK3CG0.71263319
78CDK60.70711511
79JAK20.70409806
80CDK120.67562957
81NEK90.67313780
82MAP3K130.66192896
83ABL10.66142465
84MET0.65839815
85TGFBR10.65410622
86LCK0.64769655
87DAPK30.64526593
88PDGFRB0.63647438
89RPS6KL10.63244808
90RPS6KC10.63244808
91PTK2B0.63069793
92SYK0.62055730
93LATS20.61926662
94CAMK1G0.61650709
95PDGFRA0.61552681
96TXK0.60253720
97MST40.59858183
98MAP3K100.59575382
99PAK20.58131595
100MAP3K60.57751323
101PDK20.56820820
102TYRO30.56554981
103FES0.56446574
104RPS6KA20.55274199
105SMG10.54885078
106MARK20.54722520
107MAPKAPK20.52337694
108PTK20.52239291
109PRKCD0.52092466
110MAPK70.50509311
111EPHA20.50471873
112MAPK120.50413377
113IRAK10.49631329
114SIK10.49599256
115BTK0.47632653
116FGFR30.46396599
117TAOK30.45441592
118RPS6KA60.45367096
119PAK10.44108724
120STK40.42996994
121CAMK1D0.42328606
122PDK10.42218181
123BMPR20.41209932
124STK30.40842721
125MAPK40.40760563
126MAP2K10.40725820
127INSR0.40517723
128ERBB30.40050434
129ARAF0.39274449
130ADRBK20.39051384
131GSK3A0.38718985
132MAPKAPK30.38128114
133PRKAA20.35955088
134DYRK1B0.34221375
135DYRK30.33963860
136MAP2K60.32104646

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.44867881
2Staphylococcus aureus infection_Homo sapiens_hsa051503.09544406
3Legionellosis_Homo sapiens_hsa051342.80922643
4Malaria_Homo sapiens_hsa051442.73812601
5Lysosome_Homo sapiens_hsa041422.56517767
6Osteoclast differentiation_Homo sapiens_hsa043802.43693908
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.42692043
8Pertussis_Homo sapiens_hsa051332.37891431
9Tuberculosis_Homo sapiens_hsa051522.26337744
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.22934564
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.18122656
12Phagosome_Homo sapiens_hsa041452.13447937
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.09016009
14TNF signaling pathway_Homo sapiens_hsa046682.06410294
15Graft-versus-host disease_Homo sapiens_hsa053322.03830325
16Rheumatoid arthritis_Homo sapiens_hsa053232.02914770
17Salmonella infection_Homo sapiens_hsa051321.93166830
18Shigellosis_Homo sapiens_hsa051311.77598188
19Apoptosis_Homo sapiens_hsa042101.60510404
20Other glycan degradation_Homo sapiens_hsa005111.60203906
21Asthma_Homo sapiens_hsa053101.59931705
22Toxoplasmosis_Homo sapiens_hsa051451.52240447
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.51363645
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50237419
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48528843
26Measles_Homo sapiens_hsa051621.47907703
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46901103
28Influenza A_Homo sapiens_hsa051641.46798810
29Autoimmune thyroid disease_Homo sapiens_hsa053201.44185115
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42805917
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42776103
32Antigen processing and presentation_Homo sapiens_hsa046121.42097756
33B cell receptor signaling pathway_Homo sapiens_hsa046621.38775917
34Amoebiasis_Homo sapiens_hsa051461.38442726
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38420057
36Hematopoietic cell lineage_Homo sapiens_hsa046401.34517122
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26684514
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.25864864
39Allograft rejection_Homo sapiens_hsa053301.22934511
40African trypanosomiasis_Homo sapiens_hsa051431.21735088
41Complement and coagulation cascades_Homo sapiens_hsa046101.15136025
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.13865895
43Type I diabetes mellitus_Homo sapiens_hsa049401.09739641
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07795724
45Hepatitis B_Homo sapiens_hsa051611.05659993
46Chemokine signaling pathway_Homo sapiens_hsa040621.04404853
47Prion diseases_Homo sapiens_hsa050201.04360123
48Chronic myeloid leukemia_Homo sapiens_hsa052201.00703469
49Sphingolipid metabolism_Homo sapiens_hsa006001.00358091
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98150115
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95712450
52Herpes simplex infection_Homo sapiens_hsa051680.95283417
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95086536
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.91885001
55Viral myocarditis_Homo sapiens_hsa054160.91104709
56Proteoglycans in cancer_Homo sapiens_hsa052050.90167058
57Hepatitis C_Homo sapiens_hsa051600.89309944
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88039268
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86609371
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.86484774
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.81892470
62Acute myeloid leukemia_Homo sapiens_hsa052210.81852121
63Small cell lung cancer_Homo sapiens_hsa052220.81733472
64Pancreatic cancer_Homo sapiens_hsa052120.80029719
65PPAR signaling pathway_Homo sapiens_hsa033200.78582004
66Bladder cancer_Homo sapiens_hsa052190.77022566
67Focal adhesion_Homo sapiens_hsa045100.71630034
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69398043
69Collecting duct acid secretion_Homo sapiens_hsa049660.66659815
70Viral carcinogenesis_Homo sapiens_hsa052030.66603198
71* HIF-1 signaling pathway_Homo sapiens_hsa040660.65573529
72p53 signaling pathway_Homo sapiens_hsa041150.65054913
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64023426
74Epstein-Barr virus infection_Homo sapiens_hsa051690.63934750
75VEGF signaling pathway_Homo sapiens_hsa043700.63340246
76ECM-receptor interaction_Homo sapiens_hsa045120.61658398
77Vibrio cholerae infection_Homo sapiens_hsa051100.58228026
78Endocytosis_Homo sapiens_hsa041440.57470808
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56358103
80Adherens junction_Homo sapiens_hsa045200.55517876
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.54402566
82Platelet activation_Homo sapiens_hsa046110.53577608
83Notch signaling pathway_Homo sapiens_hsa043300.52992443
84Renin-angiotensin system_Homo sapiens_hsa046140.52712097
85* MicroRNAs in cancer_Homo sapiens_hsa052060.52141090
86Fructose and mannose metabolism_Homo sapiens_hsa000510.49774060
87Caffeine metabolism_Homo sapiens_hsa002320.47819592
88Insulin resistance_Homo sapiens_hsa049310.46897098
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.46785465
90Prolactin signaling pathway_Homo sapiens_hsa049170.46164088
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45955750
92T cell receptor signaling pathway_Homo sapiens_hsa046600.45929866
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45439076
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45186969
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.43620866
96GnRH signaling pathway_Homo sapiens_hsa049120.43530253
97HTLV-I infection_Homo sapiens_hsa051660.42456736
98Renal cell carcinoma_Homo sapiens_hsa052110.42027847
99Nitrogen metabolism_Homo sapiens_hsa009100.40505952
100Pentose phosphate pathway_Homo sapiens_hsa000300.40043519
101* Mineral absorption_Homo sapiens_hsa049780.38232806
102mTOR signaling pathway_Homo sapiens_hsa041500.34643254
103Non-small cell lung cancer_Homo sapiens_hsa052230.33784888
104Synaptic vesicle cycle_Homo sapiens_hsa047210.33709718
105TGF-beta signaling pathway_Homo sapiens_hsa043500.33617675
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33492863
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32796651
108Prostate cancer_Homo sapiens_hsa052150.31813238
109FoxO signaling pathway_Homo sapiens_hsa040680.31482470
110Melanoma_Homo sapiens_hsa052180.31408290
111Galactose metabolism_Homo sapiens_hsa000520.30077567
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.29402672
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28095383
114Glutathione metabolism_Homo sapiens_hsa004800.27457934
115Dorso-ventral axis formation_Homo sapiens_hsa043200.27365781
116Sulfur metabolism_Homo sapiens_hsa009200.24419098

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