HMOX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.17956424
2central nervous system myelination (GO:0022010)8.17956424
3fatty acid elongation (GO:0030497)6.52830053
4proteasome assembly (GO:0043248)5.81138405
5DNA deamination (GO:0045006)5.76696501
6long-chain fatty acid biosynthetic process (GO:0042759)5.26958992
7acrosome reaction (GO:0007340)5.00882562
8fusion of sperm to egg plasma membrane (GO:0007342)4.97431953
9sperm motility (GO:0030317)4.91088679
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.88893362
11protein neddylation (GO:0045116)4.55155161
12regulation of cellular amino acid metabolic process (GO:0006521)4.47903323
13cytidine deamination (GO:0009972)4.34763319
14cytidine metabolic process (GO:0046087)4.34763319
15cytidine catabolic process (GO:0006216)4.34763319
16cell wall macromolecule metabolic process (GO:0044036)4.26640074
17cell wall macromolecule catabolic process (GO:0016998)4.26640074
18negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.25440210
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.11764291
20establishment of protein localization to mitochondrial membrane (GO:0090151)4.11716835
21DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.01946385
22multicellular organism reproduction (GO:0032504)4.00042452
23myelination (GO:0042552)3.99463006
24amyloid precursor protein metabolic process (GO:0042982)3.99185932
25ATP synthesis coupled proton transport (GO:0015986)3.98839040
26energy coupled proton transport, down electrochemical gradient (GO:0015985)3.98839040
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.98476301
28ensheathment of neurons (GO:0007272)3.98424018
29axon ensheathment (GO:0008366)3.98424018
30respiratory electron transport chain (GO:0022904)3.96027535
31regulation of cilium movement (GO:0003352)3.95804554
32cholesterol biosynthetic process (GO:0006695)3.92930024
33electron transport chain (GO:0022900)3.90687914
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.89226604
35intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.85025631
36signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.85025631
37negative regulation of ligase activity (GO:0051352)3.83518159
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.83518159
39signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.81940482
40signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.81940482
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.81940482
42rRNA modification (GO:0000154)3.81182943
43plasma membrane fusion (GO:0045026)3.79784763
44sperm capacitation (GO:0048240)3.78749433
45mannosylation (GO:0097502)3.78665672
46sperm-egg recognition (GO:0035036)3.74602572
47NADH dehydrogenase complex assembly (GO:0010257)3.72802815
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.72802815
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.72802815
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.71462222
51termination of RNA polymerase III transcription (GO:0006386)3.71462222
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.71362829
53L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.67046893
54signal transduction involved in DNA damage checkpoint (GO:0072422)3.66122168
55signal transduction involved in DNA integrity checkpoint (GO:0072401)3.66122168
56negative regulation of neurotransmitter transport (GO:0051589)3.65769020
57antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.62432453
58sterol biosynthetic process (GO:0016126)3.62262375
59chaperone-mediated protein transport (GO:0072321)3.61766673
60protein complex biogenesis (GO:0070271)3.61674828
61pseudouridine synthesis (GO:0001522)3.60289156
62regulation of isotype switching to IgG isotypes (GO:0048302)3.58586059
63pyrimidine ribonucleoside catabolic process (GO:0046133)3.57983211
64signal transduction involved in cell cycle checkpoint (GO:0072395)3.57974833
65negative regulation of inclusion body assembly (GO:0090084)3.52868271
66amyloid precursor protein catabolic process (GO:0042987)3.52548267
67establishment of mitochondrion localization (GO:0051654)3.52111251
68response to methylmercury (GO:0051597)3.51991388
69epithelial cilium movement (GO:0003351)3.51334416
70protein deneddylation (GO:0000338)3.48271928
71signal peptide processing (GO:0006465)3.45812472
72positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.45725320
73axonemal dynein complex assembly (GO:0070286)3.44702222
74protein targeting to mitochondrion (GO:0006626)3.43231856
75myelin maintenance (GO:0043217)3.42833656
76metallo-sulfur cluster assembly (GO:0031163)3.42767286
77iron-sulfur cluster assembly (GO:0016226)3.42767286
78regulation of cellular amine metabolic process (GO:0033238)3.42487721
79substantia nigra development (GO:0021762)3.42281391
80anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.42131151
81reproduction (GO:0000003)3.41928292
82long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.37277509
83acrosome assembly (GO:0001675)3.33192045
84galactose catabolic process (GO:0019388)3.32316484
85cellular response to interleukin-15 (GO:0071350)3.31198620
86regulation of collateral sprouting (GO:0048670)3.30529410
87binding of sperm to zona pellucida (GO:0007339)3.30378927
88positive regulation of ligase activity (GO:0051351)3.29602611
89establishment of protein localization to mitochondrion (GO:0072655)3.29364381
90long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.29168257
91rRNA methylation (GO:0031167)3.29018581
92isoprenoid biosynthetic process (GO:0008299)3.28108517
93cell-cell recognition (GO:0009988)3.27887592
94negative regulation of neurotransmitter secretion (GO:0046929)3.26954712
95galactose metabolic process (GO:0006012)3.26664509
96mitochondrial respiratory chain complex assembly (GO:0033108)3.25693710
97GPI anchor biosynthetic process (GO:0006506)3.24632455
98response to redox state (GO:0051775)3.22681153
99respiratory chain complex IV assembly (GO:0008535)3.20981945
100single fertilization (GO:0007338)3.16305467
101ATP hydrolysis coupled proton transport (GO:0015991)3.15472521
102energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.15472521
103positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.14986356
104spermatid development (GO:0007286)3.13379394
105positive regulation of oligodendrocyte differentiation (GO:0048714)3.13256754
106cytochrome complex assembly (GO:0017004)3.12717024
107protein localization to mitochondrion (GO:0070585)3.12154324
108neutrophil activation involved in immune response (GO:0002283)3.11882425
109intracellular pH reduction (GO:0051452)3.11797708
110tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.10105743
111RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.10105743
112GDP-mannose metabolic process (GO:0019673)3.10013023
113protein localization to cilium (GO:0061512)3.06683221
114base-excision repair, AP site formation (GO:0006285)3.06511647
115microtubule polymerization or depolymerization (GO:0031109)3.05384436
116fatty-acyl-CoA metabolic process (GO:0035337)3.04676952
117negative regulation of protein localization to cell surface (GO:2000009)3.04224875
118regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.03530040
119antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.02542598
120cellular response to interferon-beta (GO:0035458)3.01904057
121positive regulation of cell cycle arrest (GO:0071158)3.01809537
122DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.01004556
123pH reduction (GO:0045851)2.99311807
124hydrogen ion transmembrane transport (GO:1902600)2.98556608
125response to interferon-beta (GO:0035456)2.97020626
126regulation of microtubule-based movement (GO:0060632)2.95261664
127negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.94923021
128GPI anchor metabolic process (GO:0006505)2.91257962
129presynaptic membrane organization (GO:0097090)2.90991164
130glycosylceramide metabolic process (GO:0006677)2.90809219
131regulation of ubiquitin-protein transferase activity (GO:0051438)2.89467487
132regulation of mitochondrial translation (GO:0070129)2.89427749
133protein maturation by protein folding (GO:0022417)2.86872317
134GTP biosynthetic process (GO:0006183)2.86601034
135fatty-acyl-CoA biosynthetic process (GO:0046949)2.84176629
136regulation of lipoprotein metabolic process (GO:0050746)2.84080220
137proton transport (GO:0015992)2.82855030
138cilium or flagellum-dependent cell motility (GO:0001539)2.81667111
139L-methionine salvage (GO:0071267)2.81348378
140L-methionine biosynthetic process (GO:0071265)2.81348378
141amino acid salvage (GO:0043102)2.81348378
142creatine metabolic process (GO:0006600)2.81164483
143glycerophospholipid catabolic process (GO:0046475)2.79961754
144cilium movement (GO:0003341)2.79879600
145regulation of ligase activity (GO:0051340)2.78384521
146phagosome maturation (GO:0090382)2.76015419
147negative regulation of protein ubiquitination (GO:0031397)2.75931616
148hydrogen transport (GO:0006818)2.75834402
149regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.75473098
150inner mitochondrial membrane organization (GO:0007007)2.75330435
151protein polyglutamylation (GO:0018095)2.73165051
152calcium ion-dependent exocytosis (GO:0017156)2.72919009
153purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.72022236
154positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.71969627
155purine nucleoside triphosphate biosynthetic process (GO:0009145)2.71769370
156cullin deneddylation (GO:0010388)2.70305465
157behavioral response to nicotine (GO:0035095)2.69976121
158regulation of inclusion body assembly (GO:0090083)2.68532407
159oligodendrocyte differentiation (GO:0048709)2.67952697
160ATP biosynthetic process (GO:0006754)2.67856865
161neurotransmitter uptake (GO:0001504)2.66625523
162spermatid nucleus differentiation (GO:0007289)2.66509104
163tRNA processing (GO:0008033)2.65741854
164aldehyde catabolic process (GO:0046185)2.63241789
165sequestering of actin monomers (GO:0042989)2.62832412
166protein-cofactor linkage (GO:0018065)2.61872995
167presynaptic membrane assembly (GO:0097105)2.61046528
168positive regulation of prostaglandin secretion (GO:0032308)2.60062192
169intracellular protein transmembrane import (GO:0044743)2.59902062
170negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.59496952
171mitochondrial transport (GO:0006839)2.58960154
172regulation of cell cycle arrest (GO:0071156)2.57949485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.28014047
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.68393080
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.67608378
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.32061244
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.63839780
6TAF15_26573619_Chip-Seq_HEK293_Human2.54823494
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.46039354
8PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.44946596
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44644501
10* VDR_23849224_ChIP-Seq_CD4+_Human2.42962624
11YY1_21170310_ChIP-Seq_MESCs_Mouse2.34979453
12VDR_22108803_ChIP-Seq_LS180_Human2.32963055
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31849304
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.23747747
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.21501114
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17022444
17FOXP3_21729870_ChIP-Seq_TREG_Human2.15799631
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15219704
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15067007
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07254168
21GABP_19822575_ChIP-Seq_HepG2_Human2.03405777
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.02512973
23EZH2_22144423_ChIP-Seq_EOC_Human1.95496868
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94145281
25GBX2_23144817_ChIP-Seq_PC3_Human1.87020347
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.86014489
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.85738565
28DCP1A_22483619_ChIP-Seq_HELA_Human1.80741134
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79739739
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76858403
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75159396
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74451247
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69480182
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.69321962
35ER_23166858_ChIP-Seq_MCF-7_Human1.58638999
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.57356042
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57057311
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54434536
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54093077
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.53302964
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.53089700
42ELK1_19687146_ChIP-ChIP_HELA_Human1.47844716
43EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.47098406
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43598054
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.42735294
46* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42088765
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.40718714
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39639630
49TAL1_26923725_Chip-Seq_HPCs_Mouse1.38494843
50SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.36266872
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35144024
52XRN2_22483619_ChIP-Seq_HELA_Human1.34776358
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33957941
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33863111
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33526254
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33016776
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.32852308
58HTT_18923047_ChIP-ChIP_STHdh_Human1.32118877
59BCL6_27268052_Chip-Seq_Bcells_Human1.32070633
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31764627
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31590700
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.31072002
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.30171979
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29766018
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27954710
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27385795
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25672385
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24262352
69* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23998731
70FUS_26573619_Chip-Seq_HEK293_Human1.21236770
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18047600
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.15801688
73SOX2_19829295_ChIP-Seq_ESCs_Human1.15619886
74NANOG_19829295_ChIP-Seq_ESCs_Human1.15619886
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15542717
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15479529
77* E2F1_20622854_ChIP-Seq_HELA_Human1.14185181
78ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13756070
79STAT1_20625510_ChIP-Seq_HELA_Human1.12402283
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11418166
81CTCF_20526341_ChIP-Seq_ESCs_Human1.10924808
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10851067
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10339949
84PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08545620
85ERA_21632823_ChIP-Seq_H3396_Human1.07989259
86SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06602443
87CMYC_18555785_Chip-Seq_ESCs_Mouse1.06064115
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05415061
89BCOR_27268052_Chip-Seq_Bcells_Human1.04767522
90MYC_18940864_ChIP-ChIP_HL60_Human1.04639541
91PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04344351
92* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04222859
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04183176
94P300_18555785_Chip-Seq_ESCs_Mouse1.03892958
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03717265
96IRF8_27001747_Chip-Seq_BMDM_Mouse1.03013744
97CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01829847
98STAT3_18555785_Chip-Seq_ESCs_Mouse1.01017375
99* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00326906
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99829059
101* PHF8_20622854_ChIP-Seq_HELA_Human0.99376669
102NANOG_20526341_ChIP-Seq_ESCs_Human0.98903973
103PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97947279
104RUNX1_27457419_Chip-Seq_LIVER_Mouse0.97831432
105P300_19829295_ChIP-Seq_ESCs_Human0.96860574
106ETS1_20019798_ChIP-Seq_JURKAT_Human0.96774770
107* GATA3_26560356_Chip-Seq_TH2_Human0.96713572
108GATA3_21867929_ChIP-Seq_TH1_Mouse0.96607812
109NANOG_18555785_Chip-Seq_ESCs_Mouse0.96030883
110TTF2_22483619_ChIP-Seq_HELA_Human0.95854390
111CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95526132
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95194942
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94762894
114ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94655722
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94618040
116P53_22387025_ChIP-Seq_ESCs_Mouse0.94376926
117REST_21632747_ChIP-Seq_MESCs_Mouse0.94339487
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94274737
119* YY1_22570637_ChIP-Seq_MALME-3M_Human0.93915399
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93292926
121HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92459871
122* KDM2B_26808549_Chip-Seq_REH_Human0.92140571
123SMAD1_18555785_Chip-Seq_ESCs_Mouse0.91944001
124CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91731894
125CBX2_27304074_Chip-Seq_ESCs_Mouse0.91429882
126* FOXP1_21924763_ChIP-Seq_HESCs_Human0.91358602
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90532243
128CTCF_26484167_Chip-Seq_Bcells_Mouse0.90496185
129CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90372141
130KDM5A_27292631_Chip-Seq_BREAST_Human0.89584294
131ELF5_23300383_ChIP-Seq_T47D_Human0.89578396
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89397206
133SOX2_21211035_ChIP-Seq_LN229_Human0.89231777
134CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88748166
135CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88625812
136SOX2_18555785_Chip-Seq_ESCs_Mouse0.88302660
137RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88259605
138PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87723572
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87676497
140SOX2_22085726_ChIP-Seq_NPCs_Mouse0.87649410
141CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87354501
142PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87082433
143KLF4_18555785_Chip-Seq_ESCs_Mouse0.86880539
144BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86704535
145IRF8_22096565_ChIP-ChIP_GC-B_Human0.86489232
146P300_27268052_Chip-Seq_Bcells_Human0.86472329
147CRX_20693478_ChIP-Seq_RETINA_Mouse0.86462014
148FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85984585
149GATA1_26923725_Chip-Seq_HPCs_Mouse0.85927714
150SA1_27219007_Chip-Seq_Bcells_Human0.85561892
151MYC_19079543_ChIP-ChIP_MESCs_Mouse0.85193402
152* OCT4_20526341_ChIP-Seq_ESCs_Human0.84855128
153EOMES_21245162_ChIP-Seq_HESCs_Human0.84730593
154FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84184535
155IRF1_19129219_ChIP-ChIP_H3396_Human0.83524812
156TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83343590
157FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83187376
158TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82828080
159* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82400138
160LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81328844
161PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80668888
162HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80090722
163NCOR_22424771_ChIP-Seq_293T_Human0.79831363
164NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.79020758
165FLI1_21867929_ChIP-Seq_TH2_Mouse0.78473815
166PU1_27457419_Chip-Seq_LIVER_Mouse0.78265912
167PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77781565
168ERG_20517297_ChIP-Seq_VCAP_Human0.77418843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.18637711
2MP0000920_abnormal_myelination4.18140501
3MP0003880_abnormal_central_pattern3.55206749
4MP0001529_abnormal_vocalization3.17496043
5MP0001905_abnormal_dopamine_level3.01363242
6MP0005058_abnormal_lysosome_morphology2.61306425
7MP0003786_premature_aging2.52931885
8MP0004270_analgesia2.46292464
9MP0003011_delayed_dark_adaptation2.43693496
10MP0003806_abnormal_nucleotide_metabolis2.25293161
11MP0003690_abnormal_glial_cell2.25080936
12MP0008875_abnormal_xenobiotic_pharmacok2.23034642
13MP0003950_abnormal_plasma_membrane2.22629708
14MP0003763_abnormal_thymus_physiology2.19207437
15* MP0002272_abnormal_nervous_system2.17748833
16MP0005171_absent_coat_pigmentation2.16296431
17MP0009333_abnormal_splenocyte_physiolog2.15866290
18MP0001853_heart_inflammation2.14304431
19MP0003329_amyloid_beta_deposits2.09453512
20MP0001986_abnormal_taste_sensitivity1.99794826
21MP0004142_abnormal_muscle_tone1.95960646
22MP0003698_abnormal_male_reproductive1.95346405
23MP0002064_seizures1.88432777
24MP0008877_abnormal_DNA_methylation1.83120602
25MP0006082_CNS_inflammation1.79395195
26MP0006036_abnormal_mitochondrial_physio1.77879742
27MP0008872_abnormal_physiological_respon1.77632823
28MP0009046_muscle_twitch1.68628127
29MP0002229_neurodegeneration1.65770095
30MP0008058_abnormal_DNA_repair1.65543885
31MP0004147_increased_porphyrin_level1.64917249
32MP0003634_abnormal_glial_cell1.64050368
33MP0002734_abnormal_mechanical_nocicepti1.63214181
34MP0004043_abnormal_pH_regulation1.62857643
35MP0002138_abnormal_hepatobiliary_system1.62832281
36MP0004742_abnormal_vestibular_system1.60697526
37MP0000604_amyloidosis1.58944517
38* MP0002736_abnormal_nociception_after1.58663595
39MP0001929_abnormal_gametogenesis1.57601077
40MP0008260_abnormal_autophagy1.57025632
41MP0003866_abnormal_defecation1.46131620
42MP0003195_calcinosis1.44545853
43MP0002735_abnormal_chemical_nociception1.44273129
44MP0009745_abnormal_behavioral_response1.44255115
45MP0002148_abnormal_hypersensitivity_rea1.42016841
46MP0001970_abnormal_pain_threshold1.41541753
47MP0001486_abnormal_startle_reflex1.40298612
48MP0003631_nervous_system_phenotype1.38743283
49MP0003633_abnormal_nervous_system1.37958372
50MP0000685_abnormal_immune_system1.36380660
51MP0000372_irregular_coat_pigmentation1.36219290
52MP0000358_abnormal_cell_content/1.31698447
53MP0005332_abnormal_amino_acid1.30267178
54MP0001485_abnormal_pinna_reflex1.30168255
55MP0005084_abnormal_gallbladder_morpholo1.29334739
56MP0003632_abnormal_nervous_system1.28865298
57MP0001542_abnormal_bone_strength1.23965506
58MP0003635_abnormal_synaptic_transmissio1.22663481
59MP0004019_abnormal_vitamin_homeostasis1.21792211
60MP0003186_abnormal_redox_activity1.20678319
61MP0001835_abnormal_antigen_presentation1.20427982
62MP0002572_abnormal_emotion/affect_behav1.20251067
63MP0003656_abnormal_erythrocyte_physiolo1.20163234
64MP0009785_altered_susceptibility_to1.16693139
65MP0003724_increased_susceptibility_to1.16019835
66MP0003638_abnormal_response/metabolism_1.14111427
67MP0002420_abnormal_adaptive_immunity1.12983431
68MP0005360_urolithiasis1.12275481
69MP0001800_abnormal_humoral_immune1.11261771
70MP0001819_abnormal_immune_cell1.09863086
71MP0000427_abnormal_hair_cycle1.09068653
72MP0005451_abnormal_body_composition1.07593881
73MP0005389_reproductive_system_phenotype1.06632087
74MP0002419_abnormal_innate_immunity1.06091659
75MP0005671_abnormal_response_to1.05330744
76MP0002733_abnormal_thermal_nociception1.05282419
77MP0005083_abnormal_biliary_tract1.04537670
78MP0009840_abnormal_foam_cell1.04126271
79MP0005670_abnormal_white_adipose1.03423372
80MP0001764_abnormal_homeostasis1.02249988
81MP0008873_increased_physiological_sensi1.00358312
82MP0003646_muscle_fatigue1.00342688
83MP0006276_abnormal_autonomic_nervous0.99872224
84MP0005000_abnormal_immune_tolerance0.99748562
85MP0004782_abnormal_surfactant_physiolog0.99533912
86MP0001440_abnormal_grooming_behavior0.97438443
87MP0005409_darkened_coat_color0.96841922
88MP0002837_dystrophic_cardiac_calcinosis0.96746028
89MP0000749_muscle_degeneration0.95803550
90MP0002161_abnormal_fertility/fecundity0.95686152
91MP0005584_abnormal_enzyme/coenzyme_acti0.95503029
92MP0005365_abnormal_bile_salt0.95023512
93MP0001919_abnormal_reproductive_system0.94520077
94MP0005551_abnormal_eye_electrophysiolog0.94345610
95MP0000538_abnormal_urinary_bladder0.94241050
96MP0002063_abnormal_learning/memory/cond0.93746449
97MP0001845_abnormal_inflammatory_respons0.93296364
98MP0003136_yellow_coat_color0.93074424
99MP0005025_abnormal_response_to0.92517774
100MP0001727_abnormal_embryo_implantation0.92471311
101MP0003718_maternal_effect0.92292639
102MP0002066_abnormal_motor_capabilities/c0.91798940
103* MP0008469_abnormal_protein_level0.91687600
104* MP0002067_abnormal_sensory_capabilities0.91639904
105MP0003693_abnormal_embryo_hatching0.90714315
106MP0002452_abnormal_antigen_presenting0.89641301
107MP0004924_abnormal_behavior0.89116956
108MP0005386_behavior/neurological_phenoty0.89116956
109MP0001851_eye_inflammation0.88921640
110MP0001963_abnormal_hearing_physiology0.87035439
111MP0005423_abnormal_somatic_nervous0.86452054
112MP0002822_catalepsy0.86077716
113MP0004215_abnormal_myocardial_fiber0.85791412
114MP0003436_decreased_susceptibility_to0.85667026
115MP0002295_abnormal_pulmonary_circulatio0.84937045
116MP0009764_decreased_sensitivity_to0.84759839
117MP0005310_abnormal_salivary_gland0.84497154
118MP0005379_endocrine/exocrine_gland_phen0.84308885
119MP0001984_abnormal_olfaction0.84052283
120MP0002405_respiratory_system_inflammati0.83914089
121MP0009643_abnormal_urine_homeostasis0.83710205
122MP0003137_abnormal_impulse_conducting0.83403587
123MP0003879_abnormal_hair_cell0.83175332
124MP0004859_abnormal_synaptic_plasticity0.83107866
125MP0006035_abnormal_mitochondrial_morpho0.82264899
126MP0003183_abnormal_peptide_metabolism0.82118214
127MP0004885_abnormal_endolymph0.82042521
128MP0005085_abnormal_gallbladder_physiolo0.81793841
129MP0002163_abnormal_gland_morphology0.81474851
130MP0001501_abnormal_sleep_pattern0.81333965
131MP0010386_abnormal_urinary_bladder0.81026409
132MP0005075_abnormal_melanosome_morpholog0.80206975
133MP0005165_increased_susceptibility_to0.79642561
134MP0000703_abnormal_thymus_morphology0.79639545
135MP0002160_abnormal_reproductive_system0.79391300
136MP0002723_abnormal_immune_serum0.78680697
137MP0009697_abnormal_copulation0.78300328
138MP0005387_immune_system_phenotype0.77773610
139MP0001790_abnormal_immune_system0.77773610
140MP0003075_altered_response_to0.77527112
141MP0005408_hypopigmentation0.77478128
142MP0002882_abnormal_neuron_morphology0.76405036
143MP0008569_lethality_at_weaning0.76371974
144MP0001765_abnormal_ion_homeostasis0.75734495
145MP0002210_abnormal_sex_determination0.75029347
146* MP0001968_abnormal_touch/_nociception0.73126849
147MP0000955_abnormal_spinal_cord0.71870906
148MP0002876_abnormal_thyroid_physiology0.71072220
149MP0004381_abnormal_hair_follicle0.70996415
150MP0003191_abnormal_cellular_cholesterol0.70814049

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.74747669
2Absent/shortened dynein arms (HP:0200106)4.55121162
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.55121162
4Neurofibrillary tangles (HP:0002185)4.34713744
5Abnormal mitochondria in muscle tissue (HP:0008316)4.30647760
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.21397743
7Mitochondrial inheritance (HP:0001427)4.14825658
8Increased serum pyruvate (HP:0003542)4.09263904
9Abnormality of glycolysis (HP:0004366)4.09263904
10Hepatocellular necrosis (HP:0001404)4.05752202
11Acute encephalopathy (HP:0006846)4.01250517
12Progressive macrocephaly (HP:0004481)3.92529476
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.82232516
14Degeneration of the lateral corticospinal tracts (HP:0002314)3.82232516
15Oral leukoplakia (HP:0002745)3.76945180
16Leukodystrophy (HP:0002415)3.59425079
17Increased CSF lactate (HP:0002490)3.49191535
18Hepatic necrosis (HP:0002605)3.48148755
19Sensory axonal neuropathy (HP:0003390)3.42836434
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.27934023
21Elevated erythrocyte sedimentation rate (HP:0003565)3.26905207
22Abnormal respiratory epithelium morphology (HP:0012253)3.22107824
23Abnormal respiratory motile cilium morphology (HP:0005938)3.22107824
24Neuroendocrine neoplasm (HP:0100634)3.19296121
25Renal Fanconi syndrome (HP:0001994)3.14015179
26Abnormal respiratory motile cilium physiology (HP:0012261)3.12810612
27IgG deficiency (HP:0004315)3.10810219
28Cerebral hypomyelination (HP:0006808)3.09029990
29Pheochromocytoma (HP:0002666)3.06703898
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.06407267
313-Methylglutaconic aciduria (HP:0003535)3.05878102
32Parakeratosis (HP:0001036)2.99383044
33Cerebral inclusion bodies (HP:0100314)2.95408916
34Aplastic anemia (HP:0001915)2.92158485
35Supranuclear gaze palsy (HP:0000605)2.86933397
36Increased hepatocellular lipid droplets (HP:0006565)2.79330965
37Cerebral hemorrhage (HP:0001342)2.78058710
38Retinal dysplasia (HP:0007973)2.77377299
39Respiratory failure (HP:0002878)2.76528624
40Abnormal ciliary motility (HP:0012262)2.74097402
41Lipid accumulation in hepatocytes (HP:0006561)2.68202983
42Medial flaring of the eyebrow (HP:0010747)2.67771204
43Cerebral edema (HP:0002181)2.64386687
44Type I transferrin isoform profile (HP:0003642)2.62118131
45Rough bone trabeculation (HP:0100670)2.59225700
46Rhinitis (HP:0012384)2.55693357
47Optic disc pallor (HP:0000543)2.55682865
48Abnormality of the corticospinal tract (HP:0002492)2.53387237
49Hepatosplenomegaly (HP:0001433)2.50401792
50Delusions (HP:0000746)2.49306306
51Autoamputation (HP:0001218)2.48768530
52Lethargy (HP:0001254)2.47756840
53Hypothermia (HP:0002045)2.47291184
54Peripheral hypomyelination (HP:0007182)2.47175176
55Stomatitis (HP:0010280)2.44850099
56Generalized aminoaciduria (HP:0002909)2.42968227
57Chronic bronchitis (HP:0004469)2.40215985
58Abnormality of renal resorption (HP:0011038)2.38742714
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34273902
60Abnormality of placental membranes (HP:0011409)2.34045920
61Amniotic constriction ring (HP:0009775)2.34045920
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33349906
63Lactic acidosis (HP:0003128)2.30922103
64Vacuolated lymphocytes (HP:0001922)2.30629550
65Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.29364591
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.29364591
67Pancytopenia (HP:0001876)2.28693209
68Abnormal protein glycosylation (HP:0012346)2.27118124
69Abnormal glycosylation (HP:0012345)2.27118124
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27118124
71Abnormal protein N-linked glycosylation (HP:0012347)2.27118124
72Axonal loss (HP:0003447)2.24353866
73Increased serum lactate (HP:0002151)2.23671212
74Abnormality of T cells (HP:0002843)2.23655636
75Congenital ichthyosiform erythroderma (HP:0007431)2.23080550
76Exercise intolerance (HP:0003546)2.21470404
77Increased neuronal autofluorescent lipopigment (HP:0002074)2.21125667
78Sparse eyelashes (HP:0000653)2.20515651
79Myokymia (HP:0002411)2.15534999
80Increased intramyocellular lipid droplets (HP:0012240)2.12093857
81Infertility (HP:0000789)2.10159940
82Abnormality of alanine metabolism (HP:0010916)2.09987089
83Hyperalaninemia (HP:0003348)2.09987089
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09987089
85Slow saccadic eye movements (HP:0000514)2.09480775
86Increased IgM level (HP:0003496)2.09476222
87CNS hypomyelination (HP:0003429)2.09310418
88Abnormal trabecular bone morphology (HP:0100671)2.08888545
89Dicarboxylic aciduria (HP:0003215)2.08631766
90Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08631766
91Gait imbalance (HP:0002141)2.04689504
92Concave nail (HP:0001598)2.04108290
93Progressive neurologic deterioration (HP:0002344)2.03707560
94Opisthotonus (HP:0002179)2.03623453
95Progressive microcephaly (HP:0000253)2.02966606
96Spastic paraparesis (HP:0002313)2.02160040
97T lymphocytopenia (HP:0005403)2.01733293
98CNS demyelination (HP:0007305)2.00815336
99Methylmalonic acidemia (HP:0002912)1.99677865
100Abnormality of T cell physiology (HP:0011840)1.99251820
101Vaginal atresia (HP:0000148)1.98042132
102Congenital primary aphakia (HP:0007707)1.97955395
103Nephrogenic diabetes insipidus (HP:0009806)1.96972484
104Spastic gait (HP:0002064)1.96783147
105Type II lissencephaly (HP:0007260)1.96454927
106Increased muscle lipid content (HP:0009058)1.95748886
107Spastic tetraparesis (HP:0001285)1.94533543
108Onion bulb formation (HP:0003383)1.94234333
109Genital tract atresia (HP:0001827)1.93277537
110Tongue fasciculations (HP:0001308)1.93012491
111Unsteady gait (HP:0002317)1.92939053
112Segmental peripheral demyelination/remyelination (HP:0003481)1.92740231
113Abnormality of T cell number (HP:0011839)1.91478376
114Testicular atrophy (HP:0000029)1.91187238
115Severe combined immunodeficiency (HP:0004430)1.90244318
116Premature ovarian failure (HP:0008209)1.90205883
117Exertional dyspnea (HP:0002875)1.90073529
118Abnormal hair whorl (HP:0010721)1.88053941
119Reduced antithrombin III activity (HP:0001976)1.87761265
120Abnormality of aromatic amino acid family metabolism (HP:0004338)1.85673873
121Poor speech (HP:0002465)1.84774878
122Muscle fibrillation (HP:0010546)1.84239775
123Hypoplasia of the uterus (HP:0000013)1.83944975
124Aplasia/hypoplasia of the uterus (HP:0008684)1.82845778
125Patchy hypopigmentation of hair (HP:0011365)1.81138470
126Delayed CNS myelination (HP:0002188)1.78827435
127Increased cerebral lipofuscin (HP:0011813)1.78447226
128Pustule (HP:0200039)1.78304900
129Abnormal gallbladder physiology (HP:0012438)1.78164616
130Cholecystitis (HP:0001082)1.78164616
131Postnatal microcephaly (HP:0005484)1.77258700
132Methylmalonic aciduria (HP:0012120)1.77187864
133Emotional lability (HP:0000712)1.77021735
134Posterior subcapsular cataract (HP:0007787)1.76349491
135Hypoproteinemia (HP:0003075)1.76162069
136Hypokalemic alkalosis (HP:0001949)1.75756577
137Prolonged neonatal jaundice (HP:0006579)1.74437763
138Respiratory difficulties (HP:0002880)1.72848650
139Decreased electroretinogram (ERG) amplitude (HP:0000654)1.72822530
140Gliosis (HP:0002171)1.72115943
141Dysmetria (HP:0001310)1.71852652
142Congenital stationary night blindness (HP:0007642)1.71764124
143Abnormality of liposaccharide metabolism (HP:0010968)1.70747700
144Abnormality of glycosphingolipid metabolism (HP:0004343)1.70747700
145Abnormality of glycolipid metabolism (HP:0010969)1.70747700
146Loss of speech (HP:0002371)1.70571904
147Abnormal number of erythroid precursors (HP:0012131)1.70283999
148X-linked dominant inheritance (HP:0001423)1.69557958
149Ankle clonus (HP:0011448)1.68571821
150Abnormality of macrophages (HP:0004311)1.67739703
151Metabolic acidosis (HP:0001942)1.67669094
152Death in infancy (HP:0001522)1.66346596
153Chronic diarrhea (HP:0002028)1.66187457
154Premature graying of hair (HP:0002216)1.66165909
155Abnormality of eosinophils (HP:0001879)1.65331477
156Bronchitis (HP:0012387)1.65093024
157Recurrent abscess formation (HP:0002722)1.64956304
158Hypokinesia (HP:0002375)1.64622982
159Vomiting (HP:0002013)1.63566034

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.14243106
2OXSR13.46567426
3MAPKAPK53.25502130
4KDR3.09732435
5WNK42.61259890
6TLK12.52900636
7CDK192.39197570
8PDK32.37231851
9PDK42.37231851
10TXK2.36614225
11BCKDK2.18348530
12PDK22.17755751
13PBK2.11452490
14TESK22.02835470
15MST41.99321771
16ARAF1.84552925
17BCR1.81970789
18LIMK11.79074332
19BMPR1B1.78330445
20TESK11.74559077
21CASK1.72592311
22MAP3K111.68307610
23EPHB11.68038586
24PKN11.67822462
25MUSK1.65157495
26NME21.65144057
27STK161.64471837
28ZAK1.49416739
29PAK41.45502511
30VRK21.45269059
31DAPK11.43315833
32MAPKAPK31.42253591
33GRK71.41626431
34MAPK151.41478130
35CSNK1G31.39954773
36CLK11.36634278
37GRK61.29070333
38TRIM281.26673499
39CAMK2B1.26145760
40WNK11.23783489
41MET1.23244691
42MAP3K121.22772160
43PAK61.20395946
44NEK61.20326531
45CAMKK21.19708479
46EPHA31.19603731
47BUB11.17865826
48UHMK11.14512893
49NEK11.11155640
50PTK2B1.10008643
51ITK1.08932008
52EPHA21.07935362
53PNCK1.07807378
54MAP4K21.06564419
55PRKCI1.05615275
56EIF2AK31.05558041
57ADRBK21.05350598
58MAP2K71.03991458
59SGK2231.03932237
60SGK4941.03932237
61CAMK2D1.02576820
62GRK51.01923944
63MYLK1.01866309
64PAK31.01678916
65BMPR20.99328751
66MAP3K30.99310217
67KIT0.99066619
68FGR0.95540750
69ZAP700.94890813
70NME10.92995166
71CSF1R0.92446055
72PRPF4B0.91317474
73RIPK40.89107897
74NTRK10.88896219
75CSNK1G20.87223671
76EIF2AK10.87135446
77GRK10.87130152
78SIK30.86139890
79CSNK1G10.85563359
80CAMK2G0.85397703
81ILK0.82701807
82CSNK1A1L0.82682422
83CAMK2A0.82357900
84DYRK20.79950863
85NUAK10.79660302
86PRKD30.78280016
87DAPK20.76661903
88MINK10.76471832
89VRK10.76429680
90PRKCQ0.74916804
91PLK20.74717463
92PIK3CG0.74183888
93TNIK0.73292526
94ROCK20.72846215
95BRSK10.72408740
96SRPK10.70740160
97RPS6KA50.69739753
98LMTK20.69612846
99BLK0.66944870
100PINK10.66860303
101CDK140.65852624
102BRAF0.65581444
103IRAK40.65439243
104CCNB10.64849124
105IKBKB0.62071195
106FES0.60515416
107PRKCE0.59771000
108FGFR20.59016365
109OBSCN0.57645121
110SYK0.57442806
111CAMKK10.57176901
112CDK180.56597748
113TIE10.56537436
114PRKD20.56490188
115PDPK10.55974452
116CDK150.55363006
117MAP2K60.53934970
118PIM20.53603128
119PDK10.53544224
120CDK11A0.52301827
121AURKA0.50726324
122MKNK10.50559192
123CSK0.50280767
124LCK0.49537026
125FER0.48910562
126STK100.47868356
127ADRBK10.47761945
128TEC0.47658993
129ICK0.46908932
130EPHA40.46457843
131PRKCG0.46401453
132CDK50.46262006
133TBK10.46172184
134PAK10.43258943
135MAPK130.42016695
136TGFBR20.41545009
137MST1R0.41195794
138TSSK60.41042404
139PRKG10.39913901
140LYN0.38802541
141ABL20.38473243
142RAF10.38090440
143MAPK40.38063412
144MAP4K10.37929130
145PHKG10.37464286
146PHKG20.37464286
147BTK0.36906946
148PRKCH0.36871636
149TNK20.36746341
150DAPK30.36318270
151INSRR0.36162231
152PRKG20.35451491

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.49798500
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.93347487
3Fatty acid elongation_Homo sapiens_hsa000623.88099500
4Parkinsons disease_Homo sapiens_hsa050123.71909407
5Protein export_Homo sapiens_hsa030603.38789697
6Steroid biosynthesis_Homo sapiens_hsa001002.99615123
7Sulfur relay system_Homo sapiens_hsa041222.95115146
8Alzheimers disease_Homo sapiens_hsa050102.89039122
9Proteasome_Homo sapiens_hsa030502.61153110
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.59625408
11Collecting duct acid secretion_Homo sapiens_hsa049662.52718595
12Huntingtons disease_Homo sapiens_hsa050162.52441184
13Primary immunodeficiency_Homo sapiens_hsa053402.41688283
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33404050
15Ether lipid metabolism_Homo sapiens_hsa005652.23726809
16Vitamin B6 metabolism_Homo sapiens_hsa007502.20093140
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.11803921
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08927010
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06758338
20Pyruvate metabolism_Homo sapiens_hsa006201.88984147
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.86691842
22Vibrio cholerae infection_Homo sapiens_hsa051101.71363330
23Sulfur metabolism_Homo sapiens_hsa009201.69695429
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66403818
25Histidine metabolism_Homo sapiens_hsa003401.59214420
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58029487
27Linoleic acid metabolism_Homo sapiens_hsa005911.57391399
28Homologous recombination_Homo sapiens_hsa034401.48433192
29Rheumatoid arthritis_Homo sapiens_hsa053231.44305352
30Propanoate metabolism_Homo sapiens_hsa006401.41760690
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37783275
32Cardiac muscle contraction_Homo sapiens_hsa042601.36864966
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36733348
34Sphingolipid metabolism_Homo sapiens_hsa006001.25949046
35RNA polymerase_Homo sapiens_hsa030201.25662459
36Phagosome_Homo sapiens_hsa041451.20582863
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18307604
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09585069
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08691447
40Lysosome_Homo sapiens_hsa041421.07594065
41Mismatch repair_Homo sapiens_hsa034301.06884811
42Synaptic vesicle cycle_Homo sapiens_hsa047211.06230015
43Arachidonic acid metabolism_Homo sapiens_hsa005901.03884025
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99738120
45Basal transcription factors_Homo sapiens_hsa030220.97078079
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96867493
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96665888
48Base excision repair_Homo sapiens_hsa034100.96472052
49Glutathione metabolism_Homo sapiens_hsa004800.96195882
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94496557
51One carbon pool by folate_Homo sapiens_hsa006700.94212817
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93953850
53DNA replication_Homo sapiens_hsa030300.92757149
54Metabolic pathways_Homo sapiens_hsa011000.88855062
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88712100
56Antigen processing and presentation_Homo sapiens_hsa046120.88498182
57Butanoate metabolism_Homo sapiens_hsa006500.87511088
58Arginine and proline metabolism_Homo sapiens_hsa003300.84488074
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.84379250
60Ribosome_Homo sapiens_hsa030100.83642655
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82118166
62Folate biosynthesis_Homo sapiens_hsa007900.81438213
63Nucleotide excision repair_Homo sapiens_hsa034200.80326205
64Galactose metabolism_Homo sapiens_hsa000520.78831589
65Fatty acid metabolism_Homo sapiens_hsa012120.77920617
66Peroxisome_Homo sapiens_hsa041460.75952911
67Other glycan degradation_Homo sapiens_hsa005110.73503186
68Tryptophan metabolism_Homo sapiens_hsa003800.70636093
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70268482
70Serotonergic synapse_Homo sapiens_hsa047260.68547377
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.66999380
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.66914905
73beta-Alanine metabolism_Homo sapiens_hsa004100.65721829
74Purine metabolism_Homo sapiens_hsa002300.63907321
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63237399
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60945763
77* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60760647
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60135642
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58486383
80Nicotine addiction_Homo sapiens_hsa050330.57391265
81Selenocompound metabolism_Homo sapiens_hsa004500.57045739
82Biosynthesis of amino acids_Homo sapiens_hsa012300.55555368
83Chemical carcinogenesis_Homo sapiens_hsa052040.55456570
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.55433876
85Regulation of autophagy_Homo sapiens_hsa041400.54520857
86Shigellosis_Homo sapiens_hsa051310.54156109
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53918174
88Graft-versus-host disease_Homo sapiens_hsa053320.52877531
89Caffeine metabolism_Homo sapiens_hsa002320.51970919
90GABAergic synapse_Homo sapiens_hsa047270.51570660
91Carbon metabolism_Homo sapiens_hsa012000.50631861
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49286049
93Pyrimidine metabolism_Homo sapiens_hsa002400.47888035
94Tyrosine metabolism_Homo sapiens_hsa003500.46701361
95RNA transport_Homo sapiens_hsa030130.46420051
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44697061
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44558222
98T cell receptor signaling pathway_Homo sapiens_hsa046600.44528262
99Morphine addiction_Homo sapiens_hsa050320.43376310
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43328270
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.42736312
102Staphylococcus aureus infection_Homo sapiens_hsa051500.42685650
103Taste transduction_Homo sapiens_hsa047420.41201134
104Hematopoietic cell lineage_Homo sapiens_hsa046400.40304556
105Autoimmune thyroid disease_Homo sapiens_hsa053200.39661202
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39128742
107RNA degradation_Homo sapiens_hsa030180.38763265
108N-Glycan biosynthesis_Homo sapiens_hsa005100.38697291
109Fanconi anemia pathway_Homo sapiens_hsa034600.38324637
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37299135
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35961981
112Pertussis_Homo sapiens_hsa051330.34097194
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32910290
114Pentose phosphate pathway_Homo sapiens_hsa000300.32227418
115Glutamatergic synapse_Homo sapiens_hsa047240.32089568
116Asthma_Homo sapiens_hsa053100.30708808
117Retinol metabolism_Homo sapiens_hsa008300.30331285
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30103876
119Non-homologous end-joining_Homo sapiens_hsa034500.29370971
120Circadian entrainment_Homo sapiens_hsa047130.29337258
121Salmonella infection_Homo sapiens_hsa051320.28801784
122Endocytosis_Homo sapiens_hsa041440.28768582
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27846238
124Amphetamine addiction_Homo sapiens_hsa050310.26351410
125Olfactory transduction_Homo sapiens_hsa047400.25715081
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.25163438
127Cocaine addiction_Homo sapiens_hsa050300.22625415
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21874445
129Phototransduction_Homo sapiens_hsa047440.21044393
130Allograft rejection_Homo sapiens_hsa053300.20939377
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.20628408
132Fatty acid degradation_Homo sapiens_hsa000710.19250783
133Long-term depression_Homo sapiens_hsa047300.19246819
134Phenylalanine metabolism_Homo sapiens_hsa003600.19041580
135Vitamin digestion and absorption_Homo sapiens_hsa049770.18661181
136Glycerolipid metabolism_Homo sapiens_hsa005610.18393406
137Dopaminergic synapse_Homo sapiens_hsa047280.18170315
138Malaria_Homo sapiens_hsa051440.16805942
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.15409406
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.15128634

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