HMP19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.85736616
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.07544852
3ionotropic glutamate receptor signaling pathway (GO:0035235)5.66089318
4pyrimidine nucleobase catabolic process (GO:0006208)5.60964126
5glutamate secretion (GO:0014047)5.59794103
6postsynaptic membrane organization (GO:0001941)5.51767890
7neuron cell-cell adhesion (GO:0007158)5.45131853
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.44479620
9regulation of synaptic vesicle exocytosis (GO:2000300)5.39874439
10synaptic vesicle exocytosis (GO:0016079)5.35194834
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.22427095
12vocalization behavior (GO:0071625)5.12968835
13protein localization to synapse (GO:0035418)5.10162042
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.99846362
15exploration behavior (GO:0035640)4.81030616
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.72976640
17neurotransmitter secretion (GO:0007269)4.72028223
18regulation of synaptic vesicle transport (GO:1902803)4.65160583
19layer formation in cerebral cortex (GO:0021819)4.61296998
20locomotory exploration behavior (GO:0035641)4.60068438
21dendritic spine morphogenesis (GO:0060997)4.59980769
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.58936381
23nucleobase catabolic process (GO:0046113)4.58730541
24synaptic transmission, glutamatergic (GO:0035249)4.58504872
25establishment of mitochondrion localization (GO:0051654)4.53714762
26presynaptic membrane assembly (GO:0097105)4.45346525
27neuron recognition (GO:0008038)4.45312320
28glutamate receptor signaling pathway (GO:0007215)4.45006250
29cell migration in hindbrain (GO:0021535)4.39681821
30neurotransmitter-gated ion channel clustering (GO:0072578)4.36567500
31presynaptic membrane organization (GO:0097090)4.28760358
32axonal fasciculation (GO:0007413)4.28416783
33regulation of synapse structural plasticity (GO:0051823)4.24066486
34auditory behavior (GO:0031223)4.13018490
35neuron-neuron synaptic transmission (GO:0007270)4.12844305
36regulation of neuronal synaptic plasticity (GO:0048168)4.08537806
37regulation of glutamate receptor signaling pathway (GO:1900449)4.07723697
38cellular potassium ion homeostasis (GO:0030007)4.03950106
39establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.95809222
40mitochondrion transport along microtubule (GO:0047497)3.95809222
41gamma-aminobutyric acid transport (GO:0015812)3.90999324
42positive regulation of synapse maturation (GO:0090129)3.90841163
43cerebellar granule cell differentiation (GO:0021707)3.84577145
44transmission of nerve impulse (GO:0019226)3.79061218
45neurotransmitter transport (GO:0006836)3.77654586
46neuronal action potential propagation (GO:0019227)3.72766204
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.69911122
48regulation of long-term neuronal synaptic plasticity (GO:0048169)3.68526113
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.65916581
50dendrite morphogenesis (GO:0048813)3.64332678
51positive regulation of membrane potential (GO:0045838)3.61616945
52central nervous system projection neuron axonogenesis (GO:0021952)3.60941305
53regulation of vesicle fusion (GO:0031338)3.60751155
54sodium ion export (GO:0071436)3.58381926
55positive regulation of dendritic spine morphogenesis (GO:0061003)3.56055163
56negative regulation of synaptic transmission, GABAergic (GO:0032229)3.55482501
57regulation of postsynaptic membrane potential (GO:0060078)3.54834820
58regulation of neurotransmitter secretion (GO:0046928)3.54006721
59positive regulation of synapse assembly (GO:0051965)3.50485984
60regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.50027116
61response to auditory stimulus (GO:0010996)3.50007762
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.49394335
63regulation of neurotransmitter levels (GO:0001505)3.48743277
64neuronal ion channel clustering (GO:0045161)3.48353299
65synapse assembly (GO:0007416)3.46887722
66adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.46666344
67positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.45812545
68positive regulation of dendritic spine development (GO:0060999)3.40901728
69regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.36847324
70startle response (GO:0001964)3.34869119
71membrane depolarization during action potential (GO:0086010)3.33680306
72regulation of dendritic spine morphogenesis (GO:0061001)3.32567201
73long-term memory (GO:0007616)3.32106890
74membrane depolarization (GO:0051899)3.31210870
75synaptic vesicle endocytosis (GO:0048488)3.28273277
76cerebellar Purkinje cell differentiation (GO:0021702)3.26226378
77dendritic spine organization (GO:0097061)3.24917818
78neuromuscular synaptic transmission (GO:0007274)3.23873050
79neuromuscular process controlling balance (GO:0050885)3.21323946
80G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.20247130
81mechanosensory behavior (GO:0007638)3.20131888
82regulation of neurotransmitter transport (GO:0051588)3.18983106
83negative regulation of dendrite morphogenesis (GO:0050774)3.17429857
84regulation of synaptic transmission, glutamatergic (GO:0051966)3.14494574
85axon extension (GO:0048675)3.14485976
86positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14476446
87negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.13786472
88regulation of synapse maturation (GO:0090128)3.12047156
89regulation of synaptic plasticity (GO:0048167)3.11402162
90cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.10455965
91regulation of voltage-gated calcium channel activity (GO:1901385)3.09247718
92gamma-aminobutyric acid signaling pathway (GO:0007214)3.06635462
93synapse organization (GO:0050808)3.05998058
94neurofilament cytoskeleton organization (GO:0060052)3.04823424
95positive regulation of neurotransmitter transport (GO:0051590)3.03716062
96regulation of dendritic spine development (GO:0060998)2.98843079
97adult walking behavior (GO:0007628)2.97794239
98cerebellar Purkinje cell layer development (GO:0021680)2.95298810
99negative regulation of dendrite development (GO:2000171)2.94672898
100learning (GO:0007612)2.94410479

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.30743389
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.38279389
3REST_21632747_ChIP-Seq_MESCs_Mouse3.17188863
4GBX2_23144817_ChIP-Seq_PC3_Human3.12820995
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.12464660
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02496269
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.89117082
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.89076513
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80814024
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64128972
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64128972
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64045516
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.60852356
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.56483668
15DROSHA_22980978_ChIP-Seq_HELA_Human2.56399832
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52664604
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47266347
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45482067
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.44296726
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.43065953
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.42660622
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40430518
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35875214
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.34640323
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32432700
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10048684
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.98846179
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88195024
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85787476
30TAF15_26573619_Chip-Seq_HEK293_Human1.80929026
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.79921270
32RNF2_27304074_Chip-Seq_NSC_Mouse1.77760883
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77139485
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70793558
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62279965
36RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.61544529
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61263733
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56285603
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53951474
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53814742
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.52706642
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52051426
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49282765
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47478874
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44003537
46AR_21572438_ChIP-Seq_LNCaP_Human1.41798328
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36158859
48SMAD4_21799915_ChIP-Seq_A2780_Human1.31662895
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29061324
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.24933864
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.24616582
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24256214
53IGF1R_20145208_ChIP-Seq_DFB_Human1.23790247
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21892461
55TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20052398
56OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19428937
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15779045
58AR_19668381_ChIP-Seq_PC3_Human1.12793462
59* SOX2_21211035_ChIP-Seq_LN229_Gbm1.12674204
60YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11912332
61* SMAD3_21741376_ChIP-Seq_EPCs_Human1.11257751
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10983796
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10983796
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09773106
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09059408
66P300_19829295_ChIP-Seq_ESCs_Human1.07503716
67* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07028244
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06487429
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04910901
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01587547
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01259934
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00721754
73TP53_20018659_ChIP-ChIP_R1E_Mouse1.00291167
74GATA1_26923725_Chip-Seq_HPCs_Mouse0.99795973
75LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98333919
76KDM2B_26808549_Chip-Seq_K562_Human0.98169236
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97715629
78POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95678237
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95670430
80* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94727615
81ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94322677
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94045881
83* AR_25329375_ChIP-Seq_VCAP_Human0.94043177
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93130116
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92778121
86STAT3_23295773_ChIP-Seq_U87_Human0.91269981
87PIAS1_25552417_ChIP-Seq_VCAP_Human0.88899588
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88221656
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88173356
90CTCF_27219007_Chip-Seq_Bcells_Human0.88164190
91TCF4_23295773_ChIP-Seq_U87_Human0.86775562
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86517999
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.85214095
94STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84680608
95SOX9_26525672_Chip-Seq_HEART_Mouse0.83741708
96TET1_21490601_ChIP-Seq_MESCs_Mouse0.83314249
97* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81922921
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.81809992
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80077984
100* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.79574867

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.07676027
2MP0003880_abnormal_central_pattern4.40184465
3MP0004270_analgesia4.24518203
4MP0005423_abnormal_somatic_nervous3.93454832
5MP0003635_abnormal_synaptic_transmissio3.86336310
6MP0002063_abnormal_learning/memory/cond3.14802817
7MP0002822_catalepsy3.14202460
8MP0009745_abnormal_behavioral_response3.06929939
9MP0002064_seizures3.03492723
10MP0002734_abnormal_mechanical_nocicepti2.95195753
11MP0002572_abnormal_emotion/affect_behav2.71522578
12MP0001968_abnormal_touch/_nociception2.71336170
13MP0002272_abnormal_nervous_system2.71309153
14MP0002735_abnormal_chemical_nociception2.68130777
15MP0009046_muscle_twitch2.64851384
16MP0000778_abnormal_nervous_system2.55960200
17MP0001486_abnormal_startle_reflex2.47810513
18MP0003122_maternal_imprinting2.40725303
19MP0002736_abnormal_nociception_after2.29451642
20MP0001970_abnormal_pain_threshold2.13721134
21MP0006276_abnormal_autonomic_nervous2.05620356
22MP0002733_abnormal_thermal_nociception2.05166384
23MP0003329_amyloid_beta_deposits2.03176818
24MP0003787_abnormal_imprinting1.99863236
25MP0001440_abnormal_grooming_behavior1.97105251
26MP0001984_abnormal_olfaction1.93832652
27MP0004811_abnormal_neuron_physiology1.92177252
28MP0002184_abnormal_innervation1.84420148
29MP0002557_abnormal_social/conspecific_i1.83486201
30MP0002067_abnormal_sensory_capabilities1.82278753
31MP0008569_lethality_at_weaning1.82104325
32MP0000955_abnormal_spinal_cord1.78480546
33MP0001501_abnormal_sleep_pattern1.76711651
34MP0001188_hyperpigmentation1.68784792
35MP0002882_abnormal_neuron_morphology1.66947717
36MP0005386_behavior/neurological_phenoty1.64252006
37MP0004924_abnormal_behavior1.64252006
38MP0002638_abnormal_pupillary_reflex1.60116491
39MP0004885_abnormal_endolymph1.59873104
40MP0001905_abnormal_dopamine_level1.55913036
41MP0003879_abnormal_hair_cell1.55081913
42MP0001529_abnormal_vocalization1.45506037
43MP0002066_abnormal_motor_capabilities/c1.45293809
44MP0001502_abnormal_circadian_rhythm1.42281139
45MP0003121_genomic_imprinting1.40811578
46MP0002909_abnormal_adrenal_gland1.40193132
47MP0004742_abnormal_vestibular_system1.37273771
48MP0002152_abnormal_brain_morphology1.32202287
49MP0003633_abnormal_nervous_system1.27168474
50MP0000569_abnormal_digit_pigmentation1.24803446
51MP0005646_abnormal_pituitary_gland1.18092259
52MP0003631_nervous_system_phenotype1.15525326
53MP0004142_abnormal_muscle_tone1.15480569
54MP0005645_abnormal_hypothalamus_physiol1.08931556
55MP0001177_atelectasis1.05531900
56MP0003123_paternal_imprinting1.05481958
57MP0010386_abnormal_urinary_bladder1.04245981
58MP0003634_abnormal_glial_cell0.99130382
59MP0002752_abnormal_somatic_nervous0.98331813
60MP0002229_neurodegeneration0.94524711
61MP0002069_abnormal_eating/drinking_beha0.93448747
62MP0003632_abnormal_nervous_system0.91176787
63MP0003861_abnormal_nervous_system0.90352386
64MP0003283_abnormal_digestive_organ0.87766220
65MP0003690_abnormal_glial_cell0.86334252
66MP0000631_abnormal_neuroendocrine_gland0.84284695
67MP0000920_abnormal_myelination0.84222621
68MP0008877_abnormal_DNA_methylation0.83935592
69MP0000604_amyloidosis0.83368501
70MP0005551_abnormal_eye_electrophysiolog0.83189766
71MP0001963_abnormal_hearing_physiology0.82864498
72MP0002751_abnormal_autonomic_nervous0.79339105
73MP0005187_abnormal_penis_morphology0.73830969
74MP0009780_abnormal_chondrocyte_physiolo0.71871438
75MP0010770_preweaning_lethality0.70296177
76MP0002082_postnatal_lethality0.70296177
77MP0000026_abnormal_inner_ear0.69742803
78MP0010769_abnormal_survival0.69733239
79MP0008872_abnormal_physiological_respon0.69316914
80MP0002102_abnormal_ear_morphology0.66699477
81MP0010768_mortality/aging0.66214287
82MP0001299_abnormal_eye_distance/0.64585941
83MP0005409_darkened_coat_color0.64471908
84MP0003938_abnormal_ear_development0.63941280
85MP0005499_abnormal_olfactory_system0.62693694
86MP0005394_taste/olfaction_phenotype0.62693694
87MP0001943_abnormal_respiration0.62594699
88MP0002081_perinatal_lethality0.61395222
89MP0008874_decreased_physiological_sensi0.60524785
90MP0005535_abnormal_body_temperature0.58559659
91MP0000534_abnormal_ureter_morphology0.57523308
92MP0001485_abnormal_pinna_reflex0.54983248
93MP0004133_heterotaxia0.54391980
94MP0001986_abnormal_taste_sensitivity0.53169662
95MP0004145_abnormal_muscle_electrophysio0.51768498
96MP0003956_abnormal_body_size0.51146061
97MP0004130_abnormal_muscle_cell0.50908549
98MP0000579_abnormal_nail_morphology0.49349375
99MP0004085_abnormal_heartbeat0.49174863
100MP0003137_abnormal_impulse_conducting0.47322721

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.58094651
2Focal motor seizures (HP:0011153)7.23951570
3Focal seizures (HP:0007359)6.03608444
4Limb dystonia (HP:0002451)5.66488710
5Febrile seizures (HP:0002373)4.96997109
6Epileptic encephalopathy (HP:0200134)4.94841892
7Action tremor (HP:0002345)4.81766915
8Atonic seizures (HP:0010819)4.68576661
9Mutism (HP:0002300)4.06178340
10Generalized tonic-clonic seizures (HP:0002069)3.95894243
11Neurofibrillary tangles (HP:0002185)3.95173350
12Polyphagia (HP:0002591)3.92016831
13Supranuclear gaze palsy (HP:0000605)3.90927332
14Ankle clonus (HP:0011448)3.69023615
15Progressive cerebellar ataxia (HP:0002073)3.65769653
16Abnormality of binocular vision (HP:0011514)3.65425344
17Diplopia (HP:0000651)3.65425344
18Abnormal eating behavior (HP:0100738)3.60030010
19Dialeptic seizures (HP:0011146)3.47869106
20Drooling (HP:0002307)3.45099728
21Absence seizures (HP:0002121)3.40565769
22Torticollis (HP:0000473)3.36678719
23Akinesia (HP:0002304)3.33984144
24Abnormality of the corticospinal tract (HP:0002492)3.33738844
25Spastic gait (HP:0002064)3.24711019
26Excessive salivation (HP:0003781)3.21064190
27Cerebral inclusion bodies (HP:0100314)3.15661183
28Impaired vibration sensation in the lower limbs (HP:0002166)3.14060933
29Epileptiform EEG discharges (HP:0011182)3.13728402
30Urinary bladder sphincter dysfunction (HP:0002839)3.07274905
31Broad-based gait (HP:0002136)3.01888190
32Amyotrophic lateral sclerosis (HP:0007354)2.95470070
33EEG with generalized epileptiform discharges (HP:0011198)2.94176684
34Amblyopia (HP:0000646)2.93309570
35Urinary urgency (HP:0000012)2.92837539
36Truncal ataxia (HP:0002078)2.88526503
37Hypsarrhythmia (HP:0002521)2.85796758
38Hyperventilation (HP:0002883)2.83895153
39Focal dystonia (HP:0004373)2.70953423
40Morphological abnormality of the pyramidal tract (HP:0002062)2.66840731
41Hemiparesis (HP:0001269)2.63965977
42Postural instability (HP:0002172)2.61961454
43Sleep apnea (HP:0010535)2.59053910
44Dysmetria (HP:0001310)2.58822563
45Visual hallucinations (HP:0002367)2.55152440
46Craniofacial dystonia (HP:0012179)2.49115953
47Status epilepticus (HP:0002133)2.48344193
48Failure to thrive in infancy (HP:0001531)2.47803529
49Fetal akinesia sequence (HP:0001989)2.47066347
50Intention tremor (HP:0002080)2.45578693
51Abnormality of the lower motor neuron (HP:0002366)2.41165030
52Agitation (HP:0000713)2.40807202
53Poor eye contact (HP:0000817)2.37469878
54Hemiplegia (HP:0002301)2.37214681
55Anxiety (HP:0000739)2.37083861
56Lower limb muscle weakness (HP:0007340)2.36945244
57Depression (HP:0000716)2.36766481
58Papilledema (HP:0001085)2.32077357
59Absent speech (HP:0001344)2.31396594
60Degeneration of the lateral corticospinal tracts (HP:0002314)2.30966895
61Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.30966895
62Gait imbalance (HP:0002141)2.29356845
63Dysdiadochokinesis (HP:0002075)2.28380951
64Megalencephaly (HP:0001355)2.27043838
65Apathy (HP:0000741)2.25568529
66Bradykinesia (HP:0002067)2.20575591
67Impaired social interactions (HP:0000735)2.18151814
68Abnormal social behavior (HP:0012433)2.18151814
69Pheochromocytoma (HP:0002666)2.17160302
70Hypoplasia of the brainstem (HP:0002365)2.16786433
71Aplasia/Hypoplasia of the brainstem (HP:0007362)2.16786433
72Neuronal loss in central nervous system (HP:0002529)2.14454617
73Spastic tetraplegia (HP:0002510)2.13267986
74Diminished motivation (HP:0000745)2.08236056
75Hypoplasia of the corpus callosum (HP:0002079)2.04696592
76Lissencephaly (HP:0001339)2.04477319
77Genetic anticipation (HP:0003743)2.02611007
78Esotropia (HP:0000565)1.99227741
79Inappropriate behavior (HP:0000719)1.96274694
80Peripheral hypomyelination (HP:0007182)1.95400408
81Poor suck (HP:0002033)1.94308248
82Pachygyria (HP:0001302)1.93594481
83Clonus (HP:0002169)1.92304850
84Abnormality of salivation (HP:0100755)1.91547180
85Spastic tetraparesis (HP:0001285)1.91459281
86Impaired vibratory sensation (HP:0002495)1.91251651
87Obstructive sleep apnea (HP:0002870)1.89848829
88Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.89472041
89Delusions (HP:0000746)1.86548483
90Impaired smooth pursuit (HP:0007772)1.86398784
91Insomnia (HP:0100785)1.86089831
92Hypoventilation (HP:0002791)1.85864183
93Annular pancreas (HP:0001734)1.85236262
94Specific learning disability (HP:0001328)1.84969023
95Cortical dysplasia (HP:0002539)1.84469248
96Incomplete penetrance (HP:0003829)1.83894311
97Exotropia (HP:0000577)1.83610780
98Gaze-evoked nystagmus (HP:0000640)1.81039903
99Neuroendocrine neoplasm (HP:0100634)1.80211393
100Muscular hypotonia of the trunk (HP:0008936)1.77141223

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.78631163
2CASK4.60926230
3EPHA43.47855684
4NTRK33.17614041
5NTRK23.02157769
6SIK22.84749993
7MAPK132.40031714
8PAK62.39727015
9MINK12.31343957
10NTRK12.25004703
11DAPK22.13978001
12MAP3K92.10649790
13DYRK21.96701966
14TNIK1.96220769
15MAP3K41.95265635
16UHMK11.91349841
17PHKG11.85827119
18PHKG21.85827119
19CAMKK11.84618640
20MAP2K71.71717744
21CDK51.57968741
22PRKD31.56244074
23PRKCG1.55061910
24LATS21.51897163
25CSNK1G21.28646744
26TYRO31.28599000
27PINK11.26110608
28CDK191.25938889
29BCR1.23288360
30PNCK1.21203642
31SGK2231.20687955
32SGK4941.20687955
33PLK21.19321397
34MAP2K41.14068089
35DYRK1A1.10780135
36PAK31.09469254
37CAMK2B1.05338639
38CAMKK21.03925090
39CDK181.02156746
40CDK151.01959592
41KSR11.01155758
42CAMK2A1.01044617
43CDK140.99974596
44PKN10.98112909
45CDK11A0.94314875
46WNK30.92850139
47SGK20.92562867
48MARK20.90179643
49GRK50.84342695
50DAPK10.82935901
51PRKCH0.81417392
52PRKCZ0.79402660
53CAMK10.76466233
54CSNK1G30.69126548
55STK110.64677499
56ARAF0.64202187
57SGK10.63116158
58MAPK120.62882188
59RIPK10.58873327
60ALK0.58317018
61SGK30.56707752
62PRKCE0.55543450
63EPHB20.55340075
64CSNK1A1L0.55125140
65MAP3K120.55047600
66CAMK40.51769411
67CAMK2G0.51130947
68KSR20.50582661
69OXSR10.47902758
70CSNK1G10.46173013
71FYN0.46064220
72RPS6KA30.45289653
73MAPK100.45080090
74ERBB30.44660586
75RET0.41697600
76CAMK1G0.41401090
77CCNB10.38790188
78CSNK1D0.38537694
79ROCK20.37757457
80CSNK1E0.36338822
81CAMK2D0.36188037
82TRIM280.35987452
83RPS6KB10.35814453
84RPS6KA20.35675399
85LIMK10.33902622
86TESK10.33706359
87PRKG10.33631193
88PRKACA0.30984545
89FES0.30458154
90ERBB20.30287970
91EPHA30.30013448
92STK380.29600371
93DYRK1B0.29334393
94MAPK80.29225377
95PRKCA0.25709933
96PRKCB0.24593374
97GSK3B0.24284253
98MAPK90.23736454
99MAPK40.23654171
100NEK60.23469241

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.87697742
2Synaptic vesicle cycle_Homo sapiens_hsa047213.47544791
3GABAergic synapse_Homo sapiens_hsa047272.98764281
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87204234
5Circadian entrainment_Homo sapiens_hsa047132.87010898
6Glutamatergic synapse_Homo sapiens_hsa047242.85866593
7Amphetamine addiction_Homo sapiens_hsa050312.82447063
8Morphine addiction_Homo sapiens_hsa050322.71655484
9Long-term potentiation_Homo sapiens_hsa047202.61966477
10Cocaine addiction_Homo sapiens_hsa050302.61372353
11Dopaminergic synapse_Homo sapiens_hsa047282.52533784
12Insulin secretion_Homo sapiens_hsa049112.09010184
13Cholinergic synapse_Homo sapiens_hsa047252.08854522
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94260847
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.94168308
16Gastric acid secretion_Homo sapiens_hsa049711.75243804
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68751257
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64478350
19Axon guidance_Homo sapiens_hsa043601.62257541
20Taste transduction_Homo sapiens_hsa047421.58199744
21Long-term depression_Homo sapiens_hsa047301.57035581
22Salivary secretion_Homo sapiens_hsa049701.53415915
23Oxytocin signaling pathway_Homo sapiens_hsa049211.50094238
24Gap junction_Homo sapiens_hsa045401.44231079
25Serotonergic synapse_Homo sapiens_hsa047261.40499926
26cAMP signaling pathway_Homo sapiens_hsa040241.38127970
27Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.31800682
28Calcium signaling pathway_Homo sapiens_hsa040201.31561817
29Renin secretion_Homo sapiens_hsa049241.29960564
30Phototransduction_Homo sapiens_hsa047441.28668920
31Cardiac muscle contraction_Homo sapiens_hsa042601.23136918
32Olfactory transduction_Homo sapiens_hsa047401.20497057
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20487975
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15895537
35Estrogen signaling pathway_Homo sapiens_hsa049151.14777277
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13593414
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09852107
38GnRH signaling pathway_Homo sapiens_hsa049121.06880452
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06759034
40Collecting duct acid secretion_Homo sapiens_hsa049661.05358724
41ErbB signaling pathway_Homo sapiens_hsa040121.04011759
42Melanogenesis_Homo sapiens_hsa049161.03397317
43Type II diabetes mellitus_Homo sapiens_hsa049301.01854954
44Oocyte meiosis_Homo sapiens_hsa041140.84490021
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84413284
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84181790
47Glioma_Homo sapiens_hsa052140.83104427
48Vibrio cholerae infection_Homo sapiens_hsa051100.80116426
49Alcoholism_Homo sapiens_hsa050340.78253510
50Ras signaling pathway_Homo sapiens_hsa040140.75818094
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.75284355
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.74003524
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72237459
54MAPK signaling pathway_Homo sapiens_hsa040100.71668632
55Dilated cardiomyopathy_Homo sapiens_hsa054140.71461953
56Pancreatic secretion_Homo sapiens_hsa049720.70615956
57Thyroid hormone synthesis_Homo sapiens_hsa049180.70610742
58Rap1 signaling pathway_Homo sapiens_hsa040150.70071370
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66775996
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65114262
61Dorso-ventral axis formation_Homo sapiens_hsa043200.65023811
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64526892
63Prion diseases_Homo sapiens_hsa050200.63984511
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59004906
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.58910075
66Bile secretion_Homo sapiens_hsa049760.58270303
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57541935
68Alzheimers disease_Homo sapiens_hsa050100.57327277
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57311572
70Vitamin B6 metabolism_Homo sapiens_hsa007500.56538878
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52137180
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50443247
73VEGF signaling pathway_Homo sapiens_hsa043700.49858728
74Wnt signaling pathway_Homo sapiens_hsa043100.46240352
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43840571
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43680607
77Endometrial cancer_Homo sapiens_hsa052130.43445196
78Choline metabolism in cancer_Homo sapiens_hsa052310.43412534
79Hippo signaling pathway_Homo sapiens_hsa043900.42961705
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.42441084
81Renal cell carcinoma_Homo sapiens_hsa052110.40654065
82Circadian rhythm_Homo sapiens_hsa047100.38965266
83Glucagon signaling pathway_Homo sapiens_hsa049220.36470861
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35625789
85Endocytosis_Homo sapiens_hsa041440.34757741
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34518207
87mTOR signaling pathway_Homo sapiens_hsa041500.32511933
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32348978
89Tight junction_Homo sapiens_hsa045300.32203720
90Prolactin signaling pathway_Homo sapiens_hsa049170.32132074
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31343067
92AMPK signaling pathway_Homo sapiens_hsa041520.30447065
93Ovarian steroidogenesis_Homo sapiens_hsa049130.29301823
94Inositol phosphate metabolism_Homo sapiens_hsa005620.29135639
95Hedgehog signaling pathway_Homo sapiens_hsa043400.28677276
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27817268
97Insulin signaling pathway_Homo sapiens_hsa049100.27592340
98Parkinsons disease_Homo sapiens_hsa050120.26970631
99Colorectal cancer_Homo sapiens_hsa052100.25689643
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24957303

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