HMSD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serpin-domain containing protein that may function as a serine protease inhibitor. This gene is primarily expressed in cells of myeloid lineage. A polymorphism in this gene may result in the expression a splice variant that encodes a minor histocompatibility antigen. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)4.47900590
2DNA strand elongation involved in DNA replication (GO:0006271)4.45002766
3establishment of viral latency (GO:0019043)4.43101703
4establishment of integrated proviral latency (GO:0075713)4.42023283
5CENP-A containing nucleosome assembly (GO:0034080)4.28029599
6telomere maintenance via semi-conservative replication (GO:0032201)4.22457908
7DNA strand elongation (GO:0022616)4.22006559
8CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.96141207
9mitotic metaphase plate congression (GO:0007080)3.83137762
10deoxyribonucleotide biosynthetic process (GO:0009263)3.82084465
11telomere maintenance via recombination (GO:0000722)3.66865060
12mitotic recombination (GO:0006312)3.65844576
13telomere maintenance via telomere lengthening (GO:0010833)3.59727351
14telomere maintenance via telomerase (GO:0007004)3.54711745
15establishment of protein localization to mitochondrial membrane (GO:0090151)3.51066515
16histone exchange (GO:0043486)3.44389231
17DNA unwinding involved in DNA replication (GO:0006268)3.43304322
18DNA replication checkpoint (GO:0000076)3.40910304
19mitotic sister chromatid segregation (GO:0000070)3.40219203
20negative regulation of DNA-dependent DNA replication (GO:2000104)3.39390859
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.37921384
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.35730338
23metaphase plate congression (GO:0051310)3.35315630
24ribosome assembly (GO:0042255)3.31794522
25positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.31369826
26RNA-dependent DNA replication (GO:0006278)3.31093860
27IMP biosynthetic process (GO:0006188)3.29784344
28positive regulation of immune response to tumor cell (GO:0002839)3.21280977
29regulation of immune response to tumor cell (GO:0002837)3.21280977
30regulation of response to tumor cell (GO:0002834)3.21280977
31positive regulation of response to tumor cell (GO:0002836)3.21280977
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.20912621
33T cell lineage commitment (GO:0002360)3.20849978
34nucleotide-excision repair, DNA gap filling (GO:0006297)3.19394084
352-deoxyribonucleotide biosynthetic process (GO:0009265)3.19100701
36deoxyribose phosphate biosynthetic process (GO:0046385)3.19100701
37mitotic chromosome condensation (GO:0007076)3.18608228
38purine nucleobase biosynthetic process (GO:0009113)3.18124669
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16951667
40regulation of DNA endoreduplication (GO:0032875)3.16909184
41folic acid-containing compound biosynthetic process (GO:0009396)3.16736072
42protein localization to kinetochore (GO:0034501)3.13633828
43proteasome assembly (GO:0043248)3.13273881
44DNA replication-independent nucleosome organization (GO:0034724)3.12443835
45DNA replication-independent nucleosome assembly (GO:0006336)3.12443835
46DNA double-strand break processing (GO:0000729)3.09993409
47anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09417229
48negative regulation of ligase activity (GO:0051352)3.09396700
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.09396700
50telomere maintenance (GO:0000723)3.08141265
51telomere organization (GO:0032200)3.06192080
52cytidine deamination (GO:0009972)3.05610865
53cytidine metabolic process (GO:0046087)3.05610865
54cytidine catabolic process (GO:0006216)3.05610865
55somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.03332760
56isotype switching (GO:0045190)3.03332760
57somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.03332760
58establishment of chromosome localization (GO:0051303)3.02320720
59protein K6-linked ubiquitination (GO:0085020)2.96926224
60positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.96248187
61heterochromatin organization (GO:0070828)2.94991531
62positive regulation of alpha-beta T cell proliferation (GO:0046641)2.93689049
63nucleobase biosynthetic process (GO:0046112)2.93013662
64mitotic G2/M transition checkpoint (GO:0044818)2.91939553
65regulation of interferon-gamma biosynthetic process (GO:0045072)2.89767800
66negative regulation of telomere maintenance (GO:0032205)2.88458586
67sister chromatid segregation (GO:0000819)2.88189699
68pyrimidine ribonucleoside catabolic process (GO:0046133)2.87357596
69regulation of T-helper 1 cell differentiation (GO:0045625)2.85065847
70DNA strand renaturation (GO:0000733)2.85034521
71kinetochore organization (GO:0051383)2.84147348
72negative regulation of chromosome segregation (GO:0051985)2.83853867
73negative regulation of mitotic sister chromatid separation (GO:2000816)2.83508796
74negative regulation of sister chromatid segregation (GO:0033046)2.83508796
75negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.83508796
76negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.83508796
77negative regulation of mitotic sister chromatid segregation (GO:0033048)2.83508796
78DNA catabolic process, exonucleolytic (GO:0000738)2.83316139
79somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83118199
80somatic hypermutation of immunoglobulin genes (GO:0016446)2.83118199
81regulation of helicase activity (GO:0051095)2.82473775
82IMP metabolic process (GO:0046040)2.81239929
83myeloid dendritic cell differentiation (GO:0043011)2.80452369
84rRNA modification (GO:0000154)2.79174639
85T-helper 1 type immune response (GO:0042088)2.78753972
86protein localization to chromosome, centromeric region (GO:0071459)2.76223382
87rRNA methylation (GO:0031167)2.76044780
88DNA replication initiation (GO:0006270)2.75841024
89regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.75308109
90regulation of mitotic metaphase/anaphase transition (GO:0030071)2.75308109
91DNA replication-dependent nucleosome assembly (GO:0006335)2.75124469
92DNA replication-dependent nucleosome organization (GO:0034723)2.75124469
93regulation of alpha-beta T cell proliferation (GO:0046640)2.74948225
94DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.74598989
95mitotic nuclear envelope disassembly (GO:0007077)2.74409475
96pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.73391544
97pteridine-containing compound biosynthetic process (GO:0042559)2.72556566
98response to X-ray (GO:0010165)2.71928168
99spindle checkpoint (GO:0031577)2.71028531
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.70784147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.12545077
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.69104673
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.96220343
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.63230139
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.53332369
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.50238882
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.35933740
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.31934358
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.23792504
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.87220378
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.73479685
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.72822731
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69452142
14ELK1_19687146_ChIP-ChIP_HELA_Human2.66798992
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61613356
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.55659294
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.54554220
18AR_21909140_ChIP-Seq_LNCAP_Human2.53148095
19VDR_23849224_ChIP-Seq_CD4+_Human2.46588299
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40072154
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.39817056
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37451197
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.34134661
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.32685915
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27786543
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.26325584
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17120709
28FOXP3_21729870_ChIP-Seq_TREG_Human2.16472137
29IRF8_22096565_ChIP-ChIP_GC-B_Human2.03466913
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01031374
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97076328
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89268673
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87052412
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86102308
35DCP1A_22483619_ChIP-Seq_HELA_Human1.84631869
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83596699
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82450918
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81294109
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76992383
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.75721264
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72389494
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71985833
43TTF2_22483619_ChIP-Seq_HELA_Human1.70006668
44XRN2_22483619_ChIP-Seq_HELA_Human1.69620262
45DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.64242237
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.63796076
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53744276
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53675578
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49882072
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47910672
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.47785654
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46721842
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45669715
54MYC_18940864_ChIP-ChIP_HL60_Human1.43704798
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42035175
56GABP_19822575_ChIP-Seq_HepG2_Human1.41298535
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.38936633
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.37904305
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.36985349
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35364894
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33568651
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.31024571
63CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.27021544
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26781712
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24141590
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.23923408
67IRF1_19129219_ChIP-ChIP_H3396_Human1.23414054
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20982822
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20125656
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19850305
71MYC_22102868_ChIP-Seq_BL_Human1.15852303
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.09671983
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09314287
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09021462
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07284530
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02133652
77ELK1_22589737_ChIP-Seq_MCF10A_Human1.00968779
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00886631
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98656843
80POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98109007
81SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93941556
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92375237
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91651921
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91512126
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91459517
86EWS_26573619_Chip-Seq_HEK293_Human0.85002702
87KDM5A_27292631_Chip-Seq_BREAST_Human0.84648872
88CIITA_25753668_ChIP-Seq_RAJI_Human0.83890563
89SPI1_23547873_ChIP-Seq_NB4_Human0.83141380
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82379710
91MYB_26560356_Chip-Seq_TH2_Human0.80367931
92MYB_26560356_Chip-Seq_TH1_Human0.78675800
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.78416000
94TFEB_21752829_ChIP-Seq_HELA_Human0.77896347
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76960871
96STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.74005573
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.73332316
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.73301484
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.73088747
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.70941535

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.45194070
2MP0008057_abnormal_DNA_replication3.86859508
3MP0000685_abnormal_immune_system3.85277602
4MP0003693_abnormal_embryo_hatching3.81451474
5MP0003111_abnormal_nucleus_morphology3.44267315
6MP0003077_abnormal_cell_cycle3.05678054
7MP0001348_abnormal_lacrimal_gland3.03841901
8MP0004957_abnormal_blastocyst_morpholog3.02938717
9MP0005671_abnormal_response_to2.92963568
10MP0008058_abnormal_DNA_repair2.91101998
11MP0001835_abnormal_antigen_presentation2.57133182
12MP0001790_abnormal_immune_system2.51655943
13MP0005387_immune_system_phenotype2.51655943
14MP0001800_abnormal_humoral_immune2.45383727
15MP0002163_abnormal_gland_morphology2.42959576
16MP0001346_abnormal_lacrimal_gland2.23072310
17MP0005310_abnormal_salivary_gland2.13037094
18MP0003941_abnormal_skin_development2.06729470
19MP0003806_abnormal_nucleotide_metabolis2.05018374
20MP0002452_abnormal_antigen_presenting2.00980344
21MP0008932_abnormal_embryonic_tissue1.93738453
22MP0005000_abnormal_immune_tolerance1.93723714
23MP0002006_tumorigenesis1.87870738
24MP0009785_altered_susceptibility_to1.86410274
25MP0003718_maternal_effect1.85830835
26MP0000350_abnormal_cell_proliferation1.83650413
27MP0002148_abnormal_hypersensitivity_rea1.77805918
28MP0002166_altered_tumor_susceptibility1.76794563
29MP0005623_abnormal_meninges_morphology1.76752309
30MP0008007_abnormal_cellular_replicative1.71963883
31MP0002723_abnormal_immune_serum1.71876423
32MP0008877_abnormal_DNA_methylation1.67700891
33MP0003786_premature_aging1.55012254
34MP0009333_abnormal_splenocyte_physiolog1.53532446
35MP0002398_abnormal_bone_marrow1.52946846
36MP0001819_abnormal_immune_cell1.48718793
37MP0002420_abnormal_adaptive_immunity1.48433508
38MP0005645_abnormal_hypothalamus_physiol1.46997297
39MP0002138_abnormal_hepatobiliary_system1.44460300
40MP0006035_abnormal_mitochondrial_morpho1.44166735
41MP0000716_abnormal_immune_system1.35528358
42MP0001529_abnormal_vocalization1.28995721
43MP0000313_abnormal_cell_death1.28897370
44MP0000689_abnormal_spleen_morphology1.28706223
45MP0002019_abnormal_tumor_incidence1.24719164
46MP0002254_reproductive_system_inflammat1.24256939
47MP0002429_abnormal_blood_cell1.23549563
48MP0005379_endocrine/exocrine_gland_phen1.16396383
49MP0001727_abnormal_embryo_implantation1.09713112
50MP0002722_abnormal_immune_system1.08620772
51MP0001984_abnormal_olfaction1.08174225
52MP0001730_embryonic_growth_arrest1.07618264
53MP0003283_abnormal_digestive_organ1.07456051
54MP0009697_abnormal_copulation1.07345401
55MP0009278_abnormal_bone_marrow1.07280425
56MP0003950_abnormal_plasma_membrane1.03047732
57MP0001697_abnormal_embryo_size1.02867621
58MP0006082_CNS_inflammation1.01759701
59MP0001853_heart_inflammation1.01236474
60MP0000703_abnormal_thymus_morphology1.00966552
61MP0010307_abnormal_tumor_latency0.99685627
62MP0009379_abnormal_foot_pigmentation0.98866252
63MP0003763_abnormal_thymus_physiology0.98731428
64MP0001845_abnormal_inflammatory_respons0.96955658
65MP0000358_abnormal_cell_content/0.96011658
66MP0002102_abnormal_ear_morphology0.95887550
67MP0002396_abnormal_hematopoietic_system0.95708776
68MP0005394_taste/olfaction_phenotype0.94031443
69MP0005499_abnormal_olfactory_system0.94031443
70MP0005025_abnormal_response_to0.91166767
71MP0006036_abnormal_mitochondrial_physio0.89855380
72MP0009672_abnormal_birth_weight0.89660349
73MP0003221_abnormal_cardiomyocyte_apopto0.89330848
74MP0000490_abnormal_crypts_of0.89073386
75MP0008789_abnormal_olfactory_epithelium0.88010712
76MP0005395_other_phenotype0.87815472
77MP0004510_myositis0.85233420
78MP0003890_abnormal_embryonic-extraembry0.84142562
79MP0004808_abnormal_hematopoietic_stem0.79624856
80MP0003303_peritoneal_inflammation0.77323872
81MP0000858_altered_metastatic_potential0.77317952
82MP0004134_abnormal_chest_morphology0.77096439
83MP0005397_hematopoietic_system_phenotyp0.77092242
84MP0001545_abnormal_hematopoietic_system0.77092242
85MP0010030_abnormal_orbit_morphology0.76071451
86MP0004742_abnormal_vestibular_system0.75617127
87MP0002405_respiratory_system_inflammati0.75154278
88MP0002080_prenatal_lethality0.73939176
89MP0005451_abnormal_body_composition0.70647036
90MP0002210_abnormal_sex_determination0.69763228
91MP0010352_gastrointestinal_tract_polyps0.69286665
92MP0008260_abnormal_autophagy0.69211296
93MP0003567_abnormal_fetal_cardiomyocyte0.68479021
94MP0000372_irregular_coat_pigmentation0.68331735
95MP0005384_cellular_phenotype0.67343265
96MP0005621_abnormal_cell_physiology0.65604263
97MP0003448_altered_tumor_morphology0.65078956
98MP0003123_paternal_imprinting0.64648319
99MP0002085_abnormal_embryonic_tissue0.63893918
100MP0002938_white_spotting0.62826547

Predicted human phenotypes

RankGene SetZ-score
1IgA deficiency (HP:0002720)5.60781229
2Chromsome breakage (HP:0040012)4.87568122
3IgM deficiency (HP:0002850)4.84982539
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.63074388
5Gastrointestinal stroma tumor (HP:0100723)4.39104689
6Abnormality of chromosome stability (HP:0003220)4.17821447
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.76939598
8Squamous cell carcinoma (HP:0002860)3.74620976
9Agammaglobulinemia (HP:0004432)3.51109659
10Abnormality of the preputium (HP:0100587)3.44466407
11Meckel diverticulum (HP:0002245)3.41864657
12Increased hepatocellular lipid droplets (HP:0006565)3.25805619
13IgG deficiency (HP:0004315)3.25423634
14Lipid accumulation in hepatocytes (HP:0006561)3.15866203
15Abnormality of the ileum (HP:0001549)3.15208102
16Recurrent sinusitis (HP:0011108)3.11188802
17Abnormality of the labia minora (HP:0012880)3.10848850
18Oral leukoplakia (HP:0002745)3.10773586
19Colon cancer (HP:0003003)3.10496903
20Reticulocytopenia (HP:0001896)3.10161595
21Birth length less than 3rd percentile (HP:0003561)2.99381333
22Abnormality of cells of the lymphoid lineage (HP:0012140)2.98811875
23Abnormality of the carotid arteries (HP:0005344)2.97472028
24Lymphopenia (HP:0001888)2.91883050
25Abnormal delayed hypersensitivity skin test (HP:0002963)2.86256891
26Medulloblastoma (HP:0002885)2.86152330
27Small intestinal stenosis (HP:0012848)2.79676377
28Duodenal stenosis (HP:0100867)2.79676377
29Increased IgM level (HP:0003496)2.66111361
30Abnormality of glycolysis (HP:0004366)2.58653298
31Aplastic anemia (HP:0001915)2.55657466
32Clubbing of toes (HP:0100760)2.54663087
33Increased serum pyruvate (HP:0003542)2.53413197
34Recurrent bronchitis (HP:0002837)2.51851601
35Absent thumb (HP:0009777)2.49624098
36Leukopenia (HP:0001882)2.44626574
37Abnormality of T cell physiology (HP:0011840)2.43160582
38Lymphoma (HP:0002665)2.43059795
39Myelodysplasia (HP:0002863)2.37136479
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.36120091
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.36120091
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33377977
43Basal cell carcinoma (HP:0002671)2.32190403
44Abnormality of the duodenum (HP:0002246)2.30486985
45Acute necrotizing encephalopathy (HP:0006965)2.28463574
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26201459
47Recurrent viral infections (HP:0004429)2.25130383
48Abnormality of DNA repair (HP:0003254)2.23488106
49Overlapping toe (HP:0001845)2.21610680
50Microvesicular hepatic steatosis (HP:0001414)2.21341584
51Increased CSF lactate (HP:0002490)2.21006624
52Horseshoe kidney (HP:0000085)2.19001209
53Nephroblastoma (Wilms tumor) (HP:0002667)2.18163776
54Hypokinesia (HP:0002375)2.16880740
55Mitochondrial inheritance (HP:0001427)2.15144212
56Hepatocellular necrosis (HP:0001404)2.15143927
57Abnormality of cells of the erythroid lineage (HP:0012130)2.14724258
58Embryonal renal neoplasm (HP:0011794)2.14548701
59Abnormal lung lobation (HP:0002101)2.14451641
60Abnormal number of incisors (HP:0011064)2.14422545
61Autoimmune hemolytic anemia (HP:0001890)2.14232455
62Exertional dyspnea (HP:0002875)2.11629875
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10750463
64Overriding aorta (HP:0002623)2.10309084
65Vasculitis (HP:0002633)2.09628028
66Increased nuchal translucency (HP:0010880)2.08182071
67Sloping forehead (HP:0000340)2.08038414
68Abnormal number of erythroid precursors (HP:0012131)2.07863635
69Renal Fanconi syndrome (HP:0001994)2.06478530
70Acute encephalopathy (HP:0006846)2.05295648
71Increased serum lactate (HP:0002151)2.04721900
72Abnormality of methionine metabolism (HP:0010901)2.02421169
73Macrocytic anemia (HP:0001972)2.00784784
74Recurrent lower respiratory tract infections (HP:0002783)1.99970977
75Cleft eyelid (HP:0000625)1.98843945
76Abnormal mitochondria in muscle tissue (HP:0008316)1.98307186
77Triphalangeal thumb (HP:0001199)1.97330287
78Progressive macrocephaly (HP:0004481)1.97079293
79B lymphocytopenia (HP:0010976)1.96722879
80Premature loss of primary teeth (HP:0006323)1.96595601
81Emphysema (HP:0002097)1.95972040
82Panhypogammaglobulinemia (HP:0003139)1.93736351
83Hepatic necrosis (HP:0002605)1.93459950
84Methylmalonic aciduria (HP:0012120)1.92789206
85Methylmalonic acidemia (HP:0002912)1.90676703
86Pancytopenia (HP:0001876)1.88211705
87Exercise-induced muscle cramps (HP:0003710)1.86725502
88Poikiloderma (HP:0001029)1.86645066
89Increased intramyocellular lipid droplets (HP:0012240)1.80432551
90Tracheoesophageal fistula (HP:0002575)1.80320897
91Abnormality of the anterior horn cell (HP:0006802)1.78827835
92Degeneration of anterior horn cells (HP:0002398)1.78827835
93Stenosis of the external auditory canal (HP:0000402)1.78236182
94Abnormality of lateral ventricle (HP:0030047)1.78096499
953-Methylglutaconic aciduria (HP:0003535)1.75601931
96Neutropenia (HP:0001875)1.75549760
97Meningitis (HP:0001287)1.75264057
98Breast hypoplasia (HP:0003187)1.74927572
99Lactic acidosis (HP:0003128)1.73577442
100Multiple enchondromatosis (HP:0005701)1.73152458

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.14082363
2BUB13.86648531
3CDC73.68368384
4TAF13.33481065
5EIF2AK33.32447570
6VRK13.01567405
7MST42.91462486
8WEE12.54328987
9PBK2.43612988
10NEK12.31175467
11TSSK62.23902230
12TTK2.19971713
13NME22.15114727
14ARAF2.02260261
15SRPK11.96102757
16PASK1.95649811
17MAP3K131.80182719
18ZAK1.78314502
19PLK41.76888510
20MAP3K91.73051596
21PLK31.72581384
22TNIK1.60434352
23BCR1.57928768
24MKNK21.47263517
25STK241.45720965
26SMG11.37584391
27NUAK11.36475814
28NME11.35643359
29EIF2AK11.34072386
30MAP3K141.29850641
31BRSK21.28013312
32STK161.27921591
33PLK11.25697927
34EIF2AK21.24646958
35MKNK11.24568728
36MELK1.17871342
37INSRR1.09100525
38RIPK41.02488210
39JAK11.01783678
40MAP4K11.00010237
41BRAF0.96170015
42NEK90.95216506
43TYK20.94522367
44DAPK30.92918224
45STK30.88876111
46AURKB0.88759570
47ATR0.86289687
48PRPF4B0.80493459
49PNCK0.80426350
50CCNB10.80027001
51STK40.79729649
52MOS0.78745117
53CHEK20.78742814
54DAPK10.77076954
55IKBKB0.76984198
56TGFBR10.76877501
57CDK190.75833271
58CDK80.71390926
59STK38L0.70306071
60BMPR1B0.70111737
61IKBKE0.70043775
62TRIM280.69702775
63CHEK10.69178830
64TBK10.69139998
65TLK10.68811604
66ALK0.68560589
67MAP3K80.67410220
68IRAK40.66492866
69STK100.61799017
70RPS6KA50.60598526
71BCKDK0.58833056
72PRKCQ0.56932627
73ACVR1B0.55809281
74GRK70.55357533
75NEK20.53026982
76BRSK10.51903987
77KIT0.51094348
78PKN10.49647773
79SIK30.49537920
80ATM0.49480351
81MAPKAPK50.48427140
82PAK10.47232881
83MAP3K50.47106262
84LIMK10.46935707
85AURKA0.45949690
86CSNK2A20.43758436
87TAOK20.43262315
88PLK20.42845607
89CDK30.41846592
90TESK20.40755478
91SYK0.40180040
92WNK30.38750927
93CSNK2A10.36343023
94MAPKAPK20.35576920
95CSNK1G10.34296078
96SIK20.34099441
97MATK0.33822148
98CDK90.33802417
99RAF10.33387720
100CDK70.32321923

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.72720712
2Proteasome_Homo sapiens_hsa030503.40762196
3Mismatch repair_Homo sapiens_hsa034303.33781986
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.32270664
5Homologous recombination_Homo sapiens_hsa034403.20158499
6Allograft rejection_Homo sapiens_hsa053302.87006548
7Ribosome_Homo sapiens_hsa030102.67817313
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.41041891
9Autoimmune thyroid disease_Homo sapiens_hsa053202.37277816
10Asthma_Homo sapiens_hsa053102.28695030
11Nucleotide excision repair_Homo sapiens_hsa034202.16354067
12Systemic lupus erythematosus_Homo sapiens_hsa053222.14923610
13Graft-versus-host disease_Homo sapiens_hsa053322.13360936
14Type I diabetes mellitus_Homo sapiens_hsa049402.12819820
15Base excision repair_Homo sapiens_hsa034102.03667501
16Non-homologous end-joining_Homo sapiens_hsa034502.03289481
17Primary immunodeficiency_Homo sapiens_hsa053402.01156255
18Protein export_Homo sapiens_hsa030601.99824886
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84616030
20Spliceosome_Homo sapiens_hsa030401.84524492
21Basal transcription factors_Homo sapiens_hsa030221.83198991
22Fanconi anemia pathway_Homo sapiens_hsa034601.78770276
23RNA polymerase_Homo sapiens_hsa030201.65914769
24One carbon pool by folate_Homo sapiens_hsa006701.62533745
25Cell cycle_Homo sapiens_hsa041101.56895493
26Oxidative phosphorylation_Homo sapiens_hsa001901.54676159
27Parkinsons disease_Homo sapiens_hsa050121.52273308
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48746534
29RNA transport_Homo sapiens_hsa030131.44176965
30Antigen processing and presentation_Homo sapiens_hsa046121.39967125
31RNA degradation_Homo sapiens_hsa030181.39620953
32Pyrimidine metabolism_Homo sapiens_hsa002401.39335225
33Viral myocarditis_Homo sapiens_hsa054161.38198374
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.37238142
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37133380
36Herpes simplex infection_Homo sapiens_hsa051681.35512382
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35457980
38Epstein-Barr virus infection_Homo sapiens_hsa051691.35429366
39Selenocompound metabolism_Homo sapiens_hsa004501.25529284
40p53 signaling pathway_Homo sapiens_hsa041151.23043646
41Influenza A_Homo sapiens_hsa051641.20682157
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20159121
43Measles_Homo sapiens_hsa051621.14735269
44Folate biosynthesis_Homo sapiens_hsa007901.12885476
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10530459
46Huntingtons disease_Homo sapiens_hsa050161.01817212
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95334510
48Viral carcinogenesis_Homo sapiens_hsa052030.93404293
49Rheumatoid arthritis_Homo sapiens_hsa053230.92214343
50Alcoholism_Homo sapiens_hsa050340.90706822
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90470879
52Alzheimers disease_Homo sapiens_hsa050100.89194158
53Propanoate metabolism_Homo sapiens_hsa006400.86148064
54Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83986444
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82792509
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81715114
57mRNA surveillance pathway_Homo sapiens_hsa030150.81367538
58Apoptosis_Homo sapiens_hsa042100.77950150
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76903202
60Purine metabolism_Homo sapiens_hsa002300.73617235
61B cell receptor signaling pathway_Homo sapiens_hsa046620.71825639
62Glutathione metabolism_Homo sapiens_hsa004800.70729545
63Biosynthesis of amino acids_Homo sapiens_hsa012300.69123377
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.66872390
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.63238339
66Pyruvate metabolism_Homo sapiens_hsa006200.61361128
67Hepatitis B_Homo sapiens_hsa051610.60193712
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59901119
69Leishmaniasis_Homo sapiens_hsa051400.58053025
70Carbon metabolism_Homo sapiens_hsa012000.57972480
71HTLV-I infection_Homo sapiens_hsa051660.57279088
72Steroid biosynthesis_Homo sapiens_hsa001000.56055659
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55434345
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53658660
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51842656
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51563374
77Vitamin B6 metabolism_Homo sapiens_hsa007500.51065856
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49617247
79Oocyte meiosis_Homo sapiens_hsa041140.49186014
80Toxoplasmosis_Homo sapiens_hsa051450.46105517
81African trypanosomiasis_Homo sapiens_hsa051430.45074203
82TNF signaling pathway_Homo sapiens_hsa046680.43791070
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41704559
84Shigellosis_Homo sapiens_hsa051310.36499012
85Legionellosis_Homo sapiens_hsa051340.35172144
86Sulfur metabolism_Homo sapiens_hsa009200.34347452
87Hepatitis C_Homo sapiens_hsa051600.25064820
88Tuberculosis_Homo sapiens_hsa051520.21417557
89Tryptophan metabolism_Homo sapiens_hsa003800.21249313
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19505287
91Staphylococcus aureus infection_Homo sapiens_hsa051500.18423065
92Prostate cancer_Homo sapiens_hsa052150.15030795
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13615773
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12832387
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12549321
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12096542
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.12037713
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.11712622
99Hematopoietic cell lineage_Homo sapiens_hsa046400.10548653
100Metabolic pathways_Homo sapiens_hsa011000.08572229

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