HMX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the NKL homeobox family of transcription factors. Members in this family are of ancient origin and play an important role in organ development during embryogenesis. A related mouse protein plays a role in patterning of inner ear structures. In humans, variations in a region containing this gene have been associated with inner ear malformations, vestibular dysfunction, and hearing loss. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)7.06913127
2presynaptic membrane organization (GO:0097090)6.85587725
3postsynaptic membrane organization (GO:0001941)5.78408699
4neuron cell-cell adhesion (GO:0007158)5.58381784
5presynaptic membrane assembly (GO:0097105)5.55688134
6positive regulation of male gonad development (GO:2000020)5.20712453
7neuronal ion channel clustering (GO:0045161)5.03919804
8axon ensheathment in central nervous system (GO:0032291)5.03718769
9central nervous system myelination (GO:0022010)5.03718769
10regulation of male gonad development (GO:2000018)4.78151587
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.62506048
12vocalization behavior (GO:0071625)4.60865037
13regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.59826618
14regulation of somitogenesis (GO:0014807)4.52227861
15neuron remodeling (GO:0016322)4.31206201
16DNA strand elongation involved in DNA replication (GO:0006271)4.24826361
17positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.21798394
18neurotransmitter uptake (GO:0001504)4.17192701
19G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.16715024
20muscle organ morphogenesis (GO:0048644)4.15775786
21axonal fasciculation (GO:0007413)4.15618495
22regulation of short-term neuronal synaptic plasticity (GO:0048172)4.11482479
23peptidyl-arginine omega-N-methylation (GO:0035247)4.08339209
24DNA strand elongation (GO:0022616)4.07445962
25positive regulation of synapse assembly (GO:0051965)4.05052584
26establishment of viral latency (GO:0019043)4.01862697
27neuron recognition (GO:0008038)4.01416495
28establishment of integrated proviral latency (GO:0075713)4.00874493
29neuron maturation (GO:0042551)3.88693176
30short-term memory (GO:0007614)3.88650697
31regulation of respiratory system process (GO:0044065)3.88120340
32telomere maintenance via semi-conservative replication (GO:0032201)3.83914530
33protein localization to chromosome, centromeric region (GO:0071459)3.82241935
34sympathetic nervous system development (GO:0048485)3.78072493
35primary amino compound metabolic process (GO:1901160)3.75929567
36glutamate receptor signaling pathway (GO:0007215)3.72076374
37negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.68127706
38forebrain neuron differentiation (GO:0021879)3.68053638
39regulation of respiratory gaseous exchange (GO:0043576)3.67674621
40neurotransmitter-gated ion channel clustering (GO:0072578)3.65971866
41DNA replication-dependent nucleosome assembly (GO:0006335)3.65332191
42DNA replication-dependent nucleosome organization (GO:0034723)3.65332191
43long-chain fatty acid biosynthetic process (GO:0042759)3.63534055
44transcription from mitochondrial promoter (GO:0006390)3.63011225
45regulation of glutamate receptor signaling pathway (GO:1900449)3.58877057
46mitotic sister chromatid segregation (GO:0000070)3.58791768
47DNA unwinding involved in DNA replication (GO:0006268)3.57384482
48protein localization to kinetochore (GO:0034501)3.56498946
49regulation of mitochondrial depolarization (GO:0051900)3.51157274
50regulation of mitochondrial translation (GO:0070129)3.50844701
51chromatin assembly (GO:0031497)3.50407440
52serotonin metabolic process (GO:0042428)3.47956324
53L-amino acid import (GO:0043092)3.47543524
54gamma-aminobutyric acid signaling pathway (GO:0007214)3.45997718
55peptidyl-arginine N-methylation (GO:0035246)3.45507417
56peptidyl-arginine methylation (GO:0018216)3.45507417
57sodium ion export (GO:0071436)3.45209881
58regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.44039483
59histone arginine methylation (GO:0034969)3.43029822
60synaptic vesicle exocytosis (GO:0016079)3.41971429
61regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.41872777
62positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.41112138
63formation of translation preinitiation complex (GO:0001731)3.38433857
64cranial nerve morphogenesis (GO:0021602)3.33613586
65activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.32896480
66righting reflex (GO:0060013)3.32614032
67regulation of interferon-gamma biosynthetic process (GO:0045072)3.30950628
68startle response (GO:0001964)3.30208601
69pseudouridine synthesis (GO:0001522)3.30108511
70regulation of histone H3-K9 methylation (GO:0051570)3.28870297
71superoxide anion generation (GO:0042554)3.26518911
72somatic diversification of immune receptors via somatic mutation (GO:0002566)3.26330732
73somatic hypermutation of immunoglobulin genes (GO:0016446)3.26330732
74spliceosomal snRNP assembly (GO:0000387)3.25485343
75opioid receptor signaling pathway (GO:0038003)3.25443110
76mitotic metaphase plate congression (GO:0007080)3.24977426
77protein localization to synapse (GO:0035418)3.24247863
78negative regulation of mRNA processing (GO:0050686)3.23873229
79inner ear receptor stereocilium organization (GO:0060122)3.22507967
80substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.22275642
81substrate-independent telencephalic tangential migration (GO:0021826)3.22275642
82developmental pigmentation (GO:0048066)3.21385977
83oligosaccharide catabolic process (GO:0009313)3.20917410
84negative regulation of RNA splicing (GO:0033119)3.17830273
85chromatin assembly or disassembly (GO:0006333)3.16404589
86ionotropic glutamate receptor signaling pathway (GO:0035235)3.15880143
87cell migration in hindbrain (GO:0021535)3.15514900
88telomere maintenance via recombination (GO:0000722)3.14080023
89CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.13093790
90thalamus development (GO:0021794)3.11678768
91sister chromatid segregation (GO:0000819)3.11432519
92mitochondrial RNA metabolic process (GO:0000959)3.11069715
93IMP biosynthetic process (GO:0006188)3.09828785
94calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.09718424
95B cell receptor signaling pathway (GO:0050853)3.08763404
96viral mRNA export from host cell nucleus (GO:0046784)3.08542967
97ribosome biogenesis (GO:0042254)3.08376069
98ribosomal small subunit biogenesis (GO:0042274)3.07245638
99negative regulation of osteoblast proliferation (GO:0033689)3.07099000
100regulation of synaptic vesicle exocytosis (GO:2000300)3.06435252
101mitotic chromosome condensation (GO:0007076)3.05057123
102regulation of synapse assembly (GO:0051963)3.05041402
103mitochondrial respiratory chain complex I assembly (GO:0032981)3.02853791
104NADH dehydrogenase complex assembly (GO:0010257)3.02853791
105mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.02853791
106T cell lineage commitment (GO:0002360)3.02693349
107cell communication by electrical coupling (GO:0010644)2.99329665
108B cell proliferation (GO:0042100)2.98456579
109rRNA transcription (GO:0009303)2.97584066
110negative regulation of homotypic cell-cell adhesion (GO:0034111)2.97328813
111termination of RNA polymerase II transcription (GO:0006369)2.96967464
112chromatin remodeling at centromere (GO:0031055)2.96868176
113maturation of SSU-rRNA (GO:0030490)2.96361557
114synaptic transmission, glutamatergic (GO:0035249)2.96115856
115polyol transport (GO:0015791)2.95754698
116regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94471903
117telomere maintenance via telomere lengthening (GO:0010833)2.93877511
118DNA replication initiation (GO:0006270)2.93409648
119B cell mediated immunity (GO:0019724)2.91963237
120SMAD protein complex assembly (GO:0007183)2.91652878
121CENP-A containing nucleosome assembly (GO:0034080)2.91130796
122mitotic nuclear envelope disassembly (GO:0007077)2.88820780
123synapse assembly (GO:0007416)2.87581516
124immunoglobulin mediated immune response (GO:0016064)2.87331279
125regulation of B cell receptor signaling pathway (GO:0050855)2.87240116
126endothelium development (GO:0003158)2.87125073
127neuronal action potential propagation (GO:0019227)2.86948435
128mRNA splicing, via spliceosome (GO:0000398)2.86447965
129RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.86447965
130response to histamine (GO:0034776)2.85823275
131B cell homeostasis (GO:0001782)2.84792350
132mitotic recombination (GO:0006312)2.84269505
133RNA splicing, via transesterification reactions (GO:0000375)2.84193015
134synaptic vesicle docking involved in exocytosis (GO:0016081)2.83566664
135regulation of interferon-beta biosynthetic process (GO:0045357)2.83537550
136nucleotide-excision repair, DNA gap filling (GO:0006297)2.83132324
137amino acid import (GO:0043090)2.81076471
138negative regulation of B cell apoptotic process (GO:0002903)2.80374750
139positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.80270938
140negative regulation of chromosome segregation (GO:0051985)2.79239125
141rRNA processing (GO:0006364)2.78954836
142ganglion development (GO:0061548)2.78301358
143ribonucleoprotein complex biogenesis (GO:0022613)2.77961288
144nucleosome assembly (GO:0006334)2.77594397
145spliceosomal tri-snRNP complex assembly (GO:0000244)2.77592635
146regulation of translational fidelity (GO:0006450)2.77049770
147post-embryonic morphogenesis (GO:0009886)2.77016973
148folic acid-containing compound biosynthetic process (GO:0009396)2.76473689
149proline biosynthetic process (GO:0006561)2.75508241
150regulation of helicase activity (GO:0051095)2.75014747
151DNA replication checkpoint (GO:0000076)2.75005610
152apical protein localization (GO:0045176)2.74699031
153regulation of translational termination (GO:0006449)2.74558377
154ATP-dependent chromatin remodeling (GO:0043044)2.74416758
155reflex (GO:0060004)2.74269314
156negative regulation of mRNA metabolic process (GO:1903312)2.73863525
157retina layer formation (GO:0010842)2.73148979
158somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.72964634
159isotype switching (GO:0045190)2.72964634
160somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.72964634
161positive regulation of action potential (GO:0045760)2.72824634
162positive regulation of protein oligomerization (GO:0032461)2.72401026
163regulation of astrocyte differentiation (GO:0048710)2.71950222
164chaperone-mediated protein transport (GO:0072321)2.71940576
165glucosamine-containing compound catabolic process (GO:1901072)2.71206940
166negative regulation of telomerase activity (GO:0051974)2.71173237
167transmission of nerve impulse (GO:0019226)2.71167322
168pyrimidine nucleobase catabolic process (GO:0006208)2.70250912
169base-excision repair (GO:0006284)2.69771955
170neurotransmitter transport (GO:0006836)2.69635717
171dendrite morphogenesis (GO:0048813)2.69458925
172IMP metabolic process (GO:0046040)2.69094312
173mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.68704058
174negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.68078918
175negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.68078918
176negative regulation of mitotic sister chromatid segregation (GO:0033048)2.68078918
177negative regulation of mitotic sister chromatid separation (GO:2000816)2.68078918
178negative regulation of sister chromatid segregation (GO:0033046)2.68078918
179somatic recombination of immunoglobulin gene segments (GO:0016447)2.67943025
180positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.67296873
181T cell migration (GO:0072678)2.66286814
182negative regulation of astrocyte differentiation (GO:0048712)2.66236475
183regulation of B cell apoptotic process (GO:0002902)2.66216667
184ribosome assembly (GO:0042255)2.66182793
185DNA ligation (GO:0006266)2.65699856
186dopamine transport (GO:0015872)2.65365239
187regulation of synapse maturation (GO:0090128)2.64727596
188heterochromatin organization (GO:0070828)2.64181230
189neuron-neuron synaptic transmission (GO:0007270)2.63721868
190regulation of timing of cell differentiation (GO:0048505)2.63230844
191membrane disassembly (GO:0030397)2.63179248
192nuclear envelope disassembly (GO:0051081)2.63179248
193inner ear receptor cell development (GO:0060119)2.62467949
194negative regulation of neurotransmitter transport (GO:0051589)2.62282942
195long-term synaptic potentiation (GO:0060291)2.61218937
196regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.60716119
197retinal rod cell development (GO:0046548)2.58226120
198organic cation transport (GO:0015695)2.57943255
199regulation of synaptic transmission, glutamatergic (GO:0051966)2.55747671
200cellular response to ammonium ion (GO:0071242)2.54550984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.85659161
2EZH2_22144423_ChIP-Seq_EOC_Human5.62292506
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.06063158
4GBX2_23144817_ChIP-Seq_PC3_Human3.84901009
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64602532
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.63547570
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.63020486
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47122170
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.42894573
10AR_21572438_ChIP-Seq_LNCaP_Human3.38720305
11MYC_22102868_ChIP-Seq_BL_Human3.33215585
12* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.30985802
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.05032899
14* EZH2_27304074_Chip-Seq_ESCs_Mouse3.04615728
15FOXM1_23109430_ChIP-Seq_U2OS_Human3.01676861
16EED_16625203_ChIP-ChIP_MESCs_Mouse3.00691169
17* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92633678
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91789398
19VDR_22108803_ChIP-Seq_LS180_Human2.85184133
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.82299674
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72872340
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.72446927
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71126223
24* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.70752407
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70488058
26* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.66344500
27* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63087513
28* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63087513
29* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62503663
30CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62447624
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57057149
32* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51930272
33MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50159773
34* CBX2_27304074_Chip-Seq_ESCs_Mouse2.46298485
35EST1_17652178_ChIP-ChIP_JURKAT_Human2.42600704
36* RNF2_27304074_Chip-Seq_ESCs_Mouse2.41345357
37VDR_21846776_ChIP-Seq_THP-1_Human2.39927053
38* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38889288
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33573414
40ETS1_20019798_ChIP-Seq_JURKAT_Human2.33471293
41CIITA_25753668_ChIP-Seq_RAJI_Human2.32171019
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31815261
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31209581
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28405003
45THAP11_20581084_ChIP-Seq_MESCs_Mouse2.26534767
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.24530848
47* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.24046858
48TAF15_26573619_Chip-Seq_HEK293_Human2.23513910
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21680379
50* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20103701
51NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19831303
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.19084849
53* EZH2_27294783_Chip-Seq_ESCs_Mouse2.18324494
54* RNF2_27304074_Chip-Seq_NSC_Mouse2.16540928
55CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16356166
56ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15844118
57XRN2_22483619_ChIP-Seq_HELA_Human2.14083949
58GABP_17652178_ChIP-ChIP_JURKAT_Human2.10002090
59E2F1_21310950_ChIP-Seq_MCF-7_Human2.08919151
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06100088
61* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05406876
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.02643017
63* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01005939
64ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00619760
65VDR_23849224_ChIP-Seq_CD4+_Human1.95994150
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.95904249
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95243052
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.94464769
69FOXP3_21729870_ChIP-Seq_TREG_Human1.89627878
70DCP1A_22483619_ChIP-Seq_HELA_Human1.87802448
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85476200
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.84821877
73FUS_26573619_Chip-Seq_HEK293_Human1.83714375
74P300_19829295_ChIP-Seq_ESCs_Human1.82783518
75IGF1R_20145208_ChIP-Seq_DFB_Human1.82369553
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82141140
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79582856
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76579577
79* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75907131
80E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74100553
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.71876858
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67395058
83REST_21632747_ChIP-Seq_MESCs_Mouse1.66113096
84GABP_19822575_ChIP-Seq_HepG2_Human1.65037009
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64760741
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63763561
87CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63005001
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.61160842
89MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60490837
90TTF2_22483619_ChIP-Seq_HELA_Human1.59825412
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.59238345
92HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58717989
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56608448
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55122304
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54883970
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54338011
97ER_23166858_ChIP-Seq_MCF-7_Human1.52061432
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51999344
99HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51574722
100NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51232904
101TP53_20018659_ChIP-ChIP_R1E_Mouse1.50821834
102SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50568304
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49822141
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48611688
105SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.46843519
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45530212
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44632871
108POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44516221
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44099096
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42574608
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.38313242
112SOX2_16153702_ChIP-ChIP_HESCs_Human1.38211531
113RING1B_27294783_Chip-Seq_NPCs_Mouse1.37940411
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35830585
115MAF_26560356_Chip-Seq_TH1_Human1.33389708
116RING1B_27294783_Chip-Seq_ESCs_Mouse1.32144112
117IRF8_22096565_ChIP-ChIP_GC-B_Human1.31596582
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30263366
119REST_18959480_ChIP-ChIP_MESCs_Mouse1.30069075
120SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29189220
121DROSHA_22980978_ChIP-Seq_HELA_Human1.27813442
122SMAD4_21799915_ChIP-Seq_A2780_Human1.27333101
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26177015
124AR_25329375_ChIP-Seq_VCAP_Human1.25644121
125* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25544752
126NANOG_18555785_Chip-Seq_ESCs_Mouse1.25283108
127TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24854110
128P53_22127205_ChIP-Seq_FIBROBLAST_Human1.24456843
129FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23647643
130KDM5A_27292631_Chip-Seq_BREAST_Human1.22380300
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22319136
132ELK1_19687146_ChIP-ChIP_HELA_Human1.22158982
133HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21925664
134ARNT_22903824_ChIP-Seq_MCF-7_Human1.20971388
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20597788
136HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19712287
137SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19208108
138TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17720203
139KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17631262
140P53_22387025_ChIP-Seq_ESCs_Mouse1.17628096
141EWS_26573619_Chip-Seq_HEK293_Human1.16341088
142OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16005989
143SALL1_21062744_ChIP-ChIP_HESCs_Human1.15809689
144MAF_26560356_Chip-Seq_TH2_Human1.14339223
145NFE2_27457419_Chip-Seq_LIVER_Mouse1.14292619
146BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13686994
147SRF_21415370_ChIP-Seq_HL-1_Mouse1.13280671
148SMAD3_21741376_ChIP-Seq_EPCs_Human1.12622674
149ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12581912
150CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12515661
151MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12146923
152TP53_18474530_ChIP-ChIP_U2OS_Human1.11743766
153EGR1_19374776_ChIP-ChIP_THP-1_Human1.11660398
154PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11260874
155EZH2_27294783_Chip-Seq_NPCs_Mouse1.10790241
156IRF1_19129219_ChIP-ChIP_H3396_Human1.10078040
157SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09817224
158CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09703157
159RUNX2_22187159_ChIP-Seq_PCA_Human1.05016619
160UTX_26944678_Chip-Seq_JUKART_Human1.04580959
161PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04532655
162STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04267392
163SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03760728
164E2F1_18555785_Chip-Seq_ESCs_Mouse1.02922635
165P300_18555785_Chip-Seq_ESCs_Mouse1.02607260
166TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02444089
167ZNF274_21170338_ChIP-Seq_K562_Hela1.02198969
168AHR_22903824_ChIP-Seq_MCF-7_Human1.01908595
169CMYC_18555785_Chip-Seq_ESCs_Mouse1.01861928
170FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01565199
171VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01452146
172STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00782710
173PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00597986
174CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00073381
175EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99971417
176SMAD_19615063_ChIP-ChIP_OVARY_Human0.99958484
177CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99812993
178GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99717831
179POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99624837
180VDR_24763502_ChIP-Seq_THP-1_Human0.99418205
181FLI1_27457419_Chip-Seq_LIVER_Mouse0.99373589
182NMYC_18555785_Chip-Seq_ESCs_Mouse0.99123397
183* MYC_18940864_ChIP-ChIP_HL60_Human0.98419676
184TFEB_21752829_ChIP-Seq_HELA_Human0.98237054
185E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98170812
186STAT3_18555785_Chip-Seq_ESCs_Mouse0.97848338
187AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97338250
188KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97060314
189ERG_21242973_ChIP-ChIP_JURKAT_Human0.97006583
190SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96329970
191SPI1_23547873_ChIP-Seq_NB4_Human0.95934273
192CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95542155
193KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94508184
194MYB_26560356_Chip-Seq_TH1_Human0.94502282
195CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94468663
196AR_21909140_ChIP-Seq_LNCAP_Human0.93292786
197POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.92331693

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous5.07234271
2* MP0005645_abnormal_hypothalamus_physiol4.93147337
3MP0010094_abnormal_chromosome_stability4.39158229
4MP0003693_abnormal_embryo_hatching4.37207884
5MP0008057_abnormal_DNA_replication4.11465482
6MP0003111_abnormal_nucleus_morphology3.95437775
7MP0003880_abnormal_central_pattern3.81379303
8MP0000685_abnormal_immune_system3.80573502
9MP0004957_abnormal_blastocyst_morpholog3.29845609
10MP0003077_abnormal_cell_cycle3.25396021
11MP0006276_abnormal_autonomic_nervous3.11880774
12MP0005671_abnormal_response_to3.03646258
13MP0003787_abnormal_imprinting2.96240313
14MP0001188_hyperpigmentation2.95704775
15MP0008058_abnormal_DNA_repair2.92556121
16MP0003122_maternal_imprinting2.86721294
17MP0001835_abnormal_antigen_presentation2.66508699
18MP0005387_immune_system_phenotype2.63719946
19MP0001790_abnormal_immune_system2.63719946
20MP0001486_abnormal_startle_reflex2.52353674
21* MP0009046_muscle_twitch2.50246145
22MP0001800_abnormal_humoral_immune2.49012069
23MP0008007_abnormal_cellular_replicative2.47662240
24MP0005646_abnormal_pituitary_gland2.41157917
25MP0002638_abnormal_pupillary_reflex2.37386071
26MP0005257_abnormal_intraocular_pressure2.32015699
27MP0004859_abnormal_synaptic_plasticity2.29050787
28MP0009745_abnormal_behavioral_response2.28581464
29MP0003635_abnormal_synaptic_transmissio2.26936513
30MP0009780_abnormal_chondrocyte_physiolo2.19784590
31MP0002396_abnormal_hematopoietic_system2.12086070
32MP0002572_abnormal_emotion/affect_behav2.09238731
33MP0005409_darkened_coat_color2.08267254
34MP0002064_seizures2.07105585
35MP0008260_abnormal_autophagy2.06394902
36MP0002272_abnormal_nervous_system2.01606122
37MP0000350_abnormal_cell_proliferation2.00413484
38MP0002063_abnormal_learning/memory/cond1.99465007
39MP0002398_abnormal_bone_marrow1.98819198
40MP0000778_abnormal_nervous_system1.93890811
41MP0009379_abnormal_foot_pigmentation1.92797407
42MP0001440_abnormal_grooming_behavior1.92599550
43MP0004742_abnormal_vestibular_system1.87654273
44MP0001968_abnormal_touch/_nociception1.85923556
45MP0003879_abnormal_hair_cell1.85065763
46MP0008932_abnormal_embryonic_tissue1.83841831
47MP0003763_abnormal_thymus_physiology1.83258778
48MP0006035_abnormal_mitochondrial_morpho1.82462930
49MP0001501_abnormal_sleep_pattern1.81943786
50MP0002452_abnormal_antigen_presenting1.77651269
51* MP0000026_abnormal_inner_ear1.77244485
52MP0001730_embryonic_growth_arrest1.76855472
53MP0008995_early_reproductive_senescence1.74720804
54MP0005000_abnormal_immune_tolerance1.72475675
55MP0002751_abnormal_autonomic_nervous1.70289602
56MP0003136_yellow_coat_color1.67136837
57MP0002736_abnormal_nociception_after1.66745067
58MP0002184_abnormal_innervation1.64959205
59MP0001502_abnormal_circadian_rhythm1.64663047
60MP0005171_absent_coat_pigmentation1.64474627
61MP0002723_abnormal_immune_serum1.64302726
62MP0002420_abnormal_adaptive_immunity1.62706888
63MP0009333_abnormal_splenocyte_physiolog1.60492141
64MP0002166_altered_tumor_susceptibility1.60065674
65MP0001819_abnormal_immune_cell1.59788851
66MP0002733_abnormal_thermal_nociception1.59499851
67MP0002067_abnormal_sensory_capabilities1.57625193
68MP0000689_abnormal_spleen_morphology1.55086308
69MP0000716_abnormal_immune_system1.54838132
70MP0000313_abnormal_cell_death1.53667857
71MP0000703_abnormal_thymus_morphology1.52124738
72MP0000490_abnormal_crypts_of1.51708671
73MP0002019_abnormal_tumor_incidence1.49983598
74MP0001986_abnormal_taste_sensitivity1.49673613
75MP0003121_genomic_imprinting1.48650014
76MP0002102_abnormal_ear_morphology1.48445804
77MP0002722_abnormal_immune_system1.47939520
78MP0001963_abnormal_hearing_physiology1.47743557
79MP0003786_premature_aging1.47440753
80MP0002429_abnormal_blood_cell1.46828010
81MP0005623_abnormal_meninges_morphology1.45530417
82MP0002557_abnormal_social/conspecific_i1.44049673
83MP0009672_abnormal_birth_weight1.39843023
84MP0002735_abnormal_chemical_nociception1.39822965
85MP0002734_abnormal_mechanical_nocicepti1.39274694
86MP0009384_cardiac_valve_regurgitation1.38662416
87MP0003183_abnormal_peptide_metabolism1.35139858
88* MP0000631_abnormal_neuroendocrine_gland1.35029445
89MP0002006_tumorigenesis1.32331590
90MP0002653_abnormal_ependyma_morphology1.29737773
91MP0008569_lethality_at_weaning1.28239962
92MP0003303_peritoneal_inflammation1.27874559
93MP0002254_reproductive_system_inflammat1.25487433
94* MP0002066_abnormal_motor_capabilities/c1.24020721
95MP0000015_abnormal_ear_pigmentation1.21196815
96MP0000569_abnormal_digit_pigmentation1.20920913
97* MP0002882_abnormal_neuron_morphology1.20183461
98MP0004142_abnormal_muscle_tone1.19994216
99MP0003718_maternal_effect1.17829260
100MP0005451_abnormal_body_composition1.16670540
101MP0005551_abnormal_eye_electrophysiolog1.16538608
102MP0006036_abnormal_mitochondrial_physio1.16400413
103MP0010307_abnormal_tumor_latency1.15839446
104MP0002080_prenatal_lethality1.13668730
105* MP0002752_abnormal_somatic_nervous1.12817245
106MP0001727_abnormal_embryo_implantation1.12170114
107MP0002138_abnormal_hepatobiliary_system1.09752545
108MP0001970_abnormal_pain_threshold1.09593768
109MP0002163_abnormal_gland_morphology1.09452591
110MP0006072_abnormal_retinal_apoptosis1.07558807
111MP0003938_abnormal_ear_development1.05028651
112MP0002148_abnormal_hypersensitivity_rea1.01931987
113MP0001697_abnormal_embryo_size1.01817262
114MP0005025_abnormal_response_to1.00277565
115MP0001485_abnormal_pinna_reflex1.00063539
116MP0003690_abnormal_glial_cell0.98458438
117* MP0002152_abnormal_brain_morphology0.98221704
118MP0001348_abnormal_lacrimal_gland0.97374723
119MP0004043_abnormal_pH_regulation0.96968402
120MP0004808_abnormal_hematopoietic_stem0.96372639
121MP0009250_abnormal_appendicular_skeleto0.95432426
122MP0001529_abnormal_vocalization0.94933657
123MP0005380_embryogenesis_phenotype0.93143815
124MP0001672_abnormal_embryogenesis/_devel0.93143815
125MP0009785_altered_susceptibility_to0.91725865
126MP0003123_paternal_imprinting0.91657519
127MP0000538_abnormal_urinary_bladder0.91624190
128MP0001905_abnormal_dopamine_level0.89184649
129MP0002876_abnormal_thyroid_physiology0.87213554
130MP0002932_abnormal_joint_morphology0.86531036
131MP0005310_abnormal_salivary_gland0.86287367
132MP0004270_analgesia0.85372064
133MP0005499_abnormal_olfactory_system0.85029935
134MP0005394_taste/olfaction_phenotype0.85029935
135MP0005360_urolithiasis0.84976142
136MP0004134_abnormal_chest_morphology0.84677237
137MP0000358_abnormal_cell_content/0.84368627
138MP0008877_abnormal_DNA_methylation0.83528929
139MP0010155_abnormal_intestine_physiology0.82691372
140MP0003941_abnormal_skin_development0.80985017
141MP0003221_abnormal_cardiomyocyte_apopto0.80302497
142MP0000049_abnormal_middle_ear0.80222667
143MP0001346_abnormal_lacrimal_gland0.80140243
144MP0002085_abnormal_embryonic_tissue0.78668054
145MP0003984_embryonic_growth_retardation0.78199766
146MP0008961_abnormal_basal_metabolism0.77878707
147MP0005501_abnormal_skin_physiology0.77816633
148MP0003172_abnormal_lysosome_physiology0.77683397
149MP0001845_abnormal_inflammatory_respons0.77252595
150MP0000003_abnormal_adipose_tissue0.75863936
151MP0005384_cellular_phenotype0.74131486
152MP0004381_abnormal_hair_follicle0.74023139
153MP0002088_abnormal_embryonic_growth/wei0.73142341
154MP0004858_abnormal_nervous_system0.72343588
155MP0006292_abnormal_olfactory_placode0.72301491
156MP0005220_abnormal_exocrine_pancreas0.71867419
157MP0003861_abnormal_nervous_system0.71206214
158MP0002069_abnormal_eating/drinking_beha0.70323897
159MP0002419_abnormal_innate_immunity0.69379006
160MP0009278_abnormal_bone_marrow0.68231457
161MP0003942_abnormal_urinary_system0.68103270
162MP0002229_neurodegeneration0.67448239
163MP0003634_abnormal_glial_cell0.67028496
164MP0001661_extended_life_span0.66905110
165MP0001664_abnormal_digestion0.66486713
166MP0000751_myopathy0.65584633
167MP0001943_abnormal_respiration0.65004035
168MP0005621_abnormal_cell_physiology0.64653293
169MP0004811_abnormal_neuron_physiology0.64372947
170MP0002086_abnormal_extraembryonic_tissu0.63253145
171MP0004197_abnormal_fetal_growth/weight/0.62032103
172MP0003959_abnormal_lean_body0.60095636
173* MP0010769_abnormal_survival0.60019121
174MP0001765_abnormal_ion_homeostasis0.59646161
175* MP0010770_preweaning_lethality0.59319603
176* MP0002082_postnatal_lethality0.59319603
177MP0001270_distended_abdomen0.59070921
178MP0002169_no_abnormal_phenotype0.56494453
179MP0002796_impaired_skin_barrier0.56073230
180MP0002873_normal_phenotype0.55372231
181MP0002210_abnormal_sex_determination0.54113551
182MP0005266_abnormal_metabolism0.53951152
183MP0004233_abnormal_muscle_weight0.47081001
184MP0002405_respiratory_system_inflammati0.46616067
185MP0002084_abnormal_developmental_patter0.46176444
186MP0001853_heart_inflammation0.45730241

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)6.35205558
2Anomalous pulmonary venous return (HP:0010772)6.21043622
3IgA deficiency (HP:0002720)5.33351297
4Abnormality of the pulmonary veins (HP:0011718)5.32449091
5Recurrent sinusitis (HP:0011108)5.19977354
6Myelomeningocele (HP:0002475)5.17186880
7IgM deficiency (HP:0002850)5.14098446
8Agammaglobulinemia (HP:0004432)5.09643365
9Lymphopenia (HP:0001888)4.27127841
10Abnormality of cells of the lymphoid lineage (HP:0012140)4.11565811
11Narrow nasal bridge (HP:0000446)3.82547463
12Epileptic encephalopathy (HP:0200134)3.74468994
13Aplasia involving bones of the upper limbs (HP:0009823)3.73826255
14Aplasia of the phalanges of the hand (HP:0009802)3.73826255
15Aplasia involving bones of the extremities (HP:0009825)3.73826255
16Febrile seizures (HP:0002373)3.56738245
17B lymphocytopenia (HP:0010976)3.52599210
18Panhypogammaglobulinemia (HP:0003139)3.43473068
19Squamous cell carcinoma (HP:0002860)3.36082782
20Hyperthyroidism (HP:0000836)3.27242043
21IgG deficiency (HP:0004315)3.25285964
22Mitochondrial inheritance (HP:0001427)3.15651294
23Hepatocellular necrosis (HP:0001404)3.09892815
24Meningitis (HP:0001287)3.07298859
25Metabolic alkalosis (HP:0200114)3.06855327
26Recurrent bronchitis (HP:0002837)3.06551376
27Recurrent viral infections (HP:0004429)3.04203637
28Meningocele (HP:0002435)2.99461228
29Lymphoma (HP:0002665)2.94836288
30Emphysema (HP:0002097)2.94468670
31Abnormality of glycolysis (HP:0004366)2.93479631
32Atonic seizures (HP:0010819)2.89216690
33Focal motor seizures (HP:0011153)2.86722523
34Abnormality of B cell number (HP:0010975)2.86131117
35Multiple enchondromatosis (HP:0005701)2.82365977
36Colon cancer (HP:0003003)2.81509498
37Renal Fanconi syndrome (HP:0001994)2.77799873
38Abnormality of T cell physiology (HP:0011840)2.76437842
39Colitis (HP:0002583)2.73854641
40Abnormal sex determination (HP:0012244)2.73634064
41Sex reversal (HP:0012245)2.73634064
42Abnormal eating behavior (HP:0100738)2.70992125
43Abnormality of the labia minora (HP:0012880)2.68310253
44Abnormality of cells of the erythroid lineage (HP:0012130)2.67372451
45Recurrent lower respiratory tract infections (HP:0002783)2.64826907
46Increased serum pyruvate (HP:0003542)2.60974312
47Long nose (HP:0003189)2.59686151
48Fetal akinesia sequence (HP:0001989)2.59304649
49Basal cell carcinoma (HP:0002671)2.58892363
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58518270
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58518270
52Acute necrotizing encephalopathy (HP:0006965)2.55870829
53Hypomagnesemia (HP:0002917)2.55542222
54Cellulitis (HP:0100658)2.54104091
55Leukopenia (HP:0001882)2.53154964
56Abnormal number of erythroid precursors (HP:0012131)2.52486937
57Focal seizures (HP:0007359)2.51766577
58Abnormality of the intervertebral disk (HP:0005108)2.50888727
59Acute lymphatic leukemia (HP:0006721)2.48875009
60Vasculitis (HP:0002633)2.48553410
61Ragged-red muscle fibers (HP:0003200)2.47033381
62Osteomalacia (HP:0002749)2.46836435
63Exotropia (HP:0000577)2.44388518
64Reticulocytopenia (HP:0001896)2.42834330
65Fibular aplasia (HP:0002990)2.42724684
66Abnormality of calcium-phosphate metabolism (HP:0100530)2.40559551
67Abnormality of renal resorption (HP:0011038)2.40308961
68Acute encephalopathy (HP:0006846)2.39198518
69Progressive muscle weakness (HP:0003323)2.36761904
70Dry hair (HP:0011359)2.34047233
71Morphological abnormality of the middle ear (HP:0008609)2.33559961
72Hypokalemic alkalosis (HP:0001949)2.33303205
73Polyphagia (HP:0002591)2.33050780
74Abnormal hair whorl (HP:0010721)2.32193770
75Oral leukoplakia (HP:0002745)2.31711196
76Hyperacusis (HP:0010780)2.31401375
77Amblyopia (HP:0000646)2.30834697
78Carpal bone hypoplasia (HP:0001498)2.30581455
79Cholecystitis (HP:0001082)2.29827171
80Abnormal gallbladder physiology (HP:0012438)2.29827171
81Polyuria (HP:0000103)2.29252118
82Submucous cleft hard palate (HP:0000176)2.28119041
83Congenital sensorineural hearing impairment (HP:0008527)2.27636371
84True hermaphroditism (HP:0010459)2.27440154
85Abnormal delayed hypersensitivity skin test (HP:0002963)2.27156786
86Absence seizures (HP:0002121)2.26831124
87Increased circulating renin level (HP:0000848)2.26659898
88Medulloblastoma (HP:0002885)2.24201275
89Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.23571049
90Birth length less than 3rd percentile (HP:0003561)2.23442152
91Increased serum lactate (HP:0002151)2.22671558
92Restrictive lung disease (HP:0002091)2.21995746
93Hyperaldosteronism (HP:0000859)2.21704127
94White forelock (HP:0002211)2.21666155
95Recurrent pneumonia (HP:0006532)2.20411646
96Abnormality of the lacrimal duct (HP:0011481)2.20296768
97Chromosomal breakage induced by crosslinking agents (HP:0003221)2.20074376
98Aplasia cutis congenita (HP:0001057)2.19855316
99Poor suck (HP:0002033)2.18645223
100Dialeptic seizures (HP:0011146)2.18357507
101Mediastinal lymphadenopathy (HP:0100721)2.17371449
102Increased intramyocellular lipid droplets (HP:0012240)2.15860243
103Thyroid-stimulating hormone excess (HP:0002925)2.15551452
104Status epilepticus (HP:0002133)2.14509792
105Chromsome breakage (HP:0040012)2.13455255
106Sensorimotor neuropathy (HP:0007141)2.12758633
107Abnormal urine phosphate concentration (HP:0012599)2.12644442
108Progressive external ophthalmoplegia (HP:0000590)2.12026710
109Aplastic anemia (HP:0001915)2.11169466
110Hyperphosphaturia (HP:0003109)2.10801845
111Increased hepatocellular lipid droplets (HP:0006565)2.09554126
112Increased nuchal translucency (HP:0010880)2.08913414
113Rough bone trabeculation (HP:0100670)2.07217373
114Bronchitis (HP:0012387)2.07092477
115Broad-based gait (HP:0002136)2.06723077
116Abnormal urine output (HP:0012590)2.06065872
117Confusion (HP:0001289)2.06002082
118Hyperactive renin-angiotensin system (HP:0000841)2.05492166
119Recurrent otitis media (HP:0000403)2.05009947
120Esotropia (HP:0000565)2.04586090
121Abnormality of the preputium (HP:0100587)2.03664526
122Hepatic necrosis (HP:0002605)2.03512168
123Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01967489
124Insomnia (HP:0100785)2.00356751
125Patchy hypopigmentation of hair (HP:0011365)1.99965652
126Lipid accumulation in hepatocytes (HP:0006561)1.99580465
127Microvesicular hepatic steatosis (HP:0001414)1.98878901
128Progressive macrocephaly (HP:0004481)1.98057982
129Abnormal respiratory epithelium morphology (HP:0012253)1.97713725
130Abnormal respiratory motile cilium morphology (HP:0005938)1.97713725
131Abnormality of binocular vision (HP:0011514)1.97161656
132Diplopia (HP:0000651)1.97161656
133Abnormality of renal excretion (HP:0011036)1.96949017
134Increased muscle lipid content (HP:0009058)1.96871647
135Sparse scalp hair (HP:0002209)1.96791492
136Cubitus valgus (HP:0002967)1.96633818
137Heterochromia iridis (HP:0001100)1.96544909
138Cutaneous syndactyly (HP:0012725)1.96368389
139Viral hepatitis (HP:0006562)1.95584833
140Progressive cerebellar ataxia (HP:0002073)1.95478619
141Increased CSF lactate (HP:0002490)1.95441708
142Chronic mucocutaneous candidiasis (HP:0002728)1.95423774
143Recurrent cutaneous fungal infections (HP:0011370)1.95423774
144Abnormal ciliary motility (HP:0012262)1.95183313
145Malnutrition (HP:0004395)1.95079712
146Abnormality of the odontoid process (HP:0003310)1.94734059
147Abnormality of the nasolacrimal system (HP:0000614)1.94449292
148Abnormal drinking behavior (HP:0030082)1.93479336
149Polydipsia (HP:0001959)1.93479336
150Limb dystonia (HP:0002451)1.93323848
151Abnormality of magnesium homeostasis (HP:0004921)1.93249154
152Hemiparesis (HP:0001269)1.93171894
153Protruding tongue (HP:0010808)1.93102299
154Abnormal mitochondria in muscle tissue (HP:0008316)1.93070647
155Generalized tonic-clonic seizures (HP:0002069)1.92793931
156Cranial hyperostosis (HP:0004437)1.91663453
157Cerebral edema (HP:0002181)1.90852519
158Midline defect of the nose (HP:0004122)1.90811265
159Osteomyelitis (HP:0002754)1.89986009
160Poikiloderma (HP:0001029)1.89757607
161Progressive hearing impairment (HP:0001730)1.89753805
162High anterior hairline (HP:0009890)1.89733359
163Aplasia of the musculature (HP:0100854)1.88341805
164Neonatal respiratory distress (HP:0002643)1.87854692
165Aplasia/Hypoplasia of the thymus (HP:0010515)1.87788079
166Exercise intolerance (HP:0003546)1.87720406
167Gastrointestinal inflammation (HP:0004386)1.87543556
168Progressive sensorineural hearing impairment (HP:0000408)1.87473250
169Cortical dysplasia (HP:0002539)1.86875309
170Prominent metopic ridge (HP:0005487)1.86602308
171Renal tubular dysfunction (HP:0000124)1.86231815
172Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.85581381
173Papilloma (HP:0012740)1.85565706
174Verrucae (HP:0200043)1.85565706
175Abnormality of chromosome stability (HP:0003220)1.85128119
176Overriding aorta (HP:0002623)1.84721186
177Premature loss of primary teeth (HP:0006323)1.84634832
178Hypoplastic left heart (HP:0004383)1.84470498
179Tubular atrophy (HP:0000092)1.84332301
180Nasolacrimal duct obstruction (HP:0000579)1.82871792
181Increased corneal curvature (HP:0100692)1.82597640
182Chronic otitis media (HP:0000389)1.81495525
183Inflammation of the large intestine (HP:0002037)1.81271904
184Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80930383
185Overlapping toe (HP:0001845)1.80805136
186Urticaria (HP:0001025)1.80691377
187Abnormality of T cells (HP:0002843)1.80602378
188Chronic diarrhea (HP:0002028)1.80136807
189Elfin facies (HP:0004428)1.79736856

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.04431810
2MKNK23.94752500
3SMG13.87892657
4VRK23.58777434
5VRK13.57963491
6CDC72.98385982
7GRK72.89278114
8MKNK12.89180962
9NTRK32.80865538
10BRD42.71632087
11MAP3K102.66132852
12TAF12.54306374
13RIPK42.46906028
14TNIK2.45368477
15NME22.42987757
16OXSR12.38591038
17BLK2.36016555
18MARK12.17251076
19EPHA32.16177923
20CDK122.15600660
21NTRK22.12326280
22BMPR1B2.03057182
23BUB11.98010083
24SIK21.95289583
25TEC1.92623555
26MAP4K11.92566530
27TTK1.88357654
28MAPK131.82568488
29EEF2K1.79971190
30NME11.72853658
31BCKDK1.70479541
32CDK31.63939535
33PAK31.62169874
34NEK11.55016945
35RPS6KA51.54733318
36MAP3K121.52751239
37AURKA1.52522109
38IRAK41.52263053
39NEK91.45076289
40BTK1.43956722
41WNK31.40034849
42IRAK21.38602590
43CDK191.38248974
44PKN11.37717001
45MAP2K71.37065598
46PRKCG1.36918470
47DAPK31.36497445
48UHMK11.36348263
49TLK11.35682225
50STK391.34284951
51ERBB31.32086490
52DYRK1A1.31492616
53MAP3K141.31231654
54MAP3K91.30848166
55PASK1.30680013
56STK41.28588484
57EPHA41.22290904
58CHEK21.18155189
59ADRBK11.17841820
60ITK1.17510690
61PAK61.16818153
62TRIB31.10693524
63WNK41.10570967
64CAMK2A1.10322464
65CSF1R1.08961409
66PRPF4B1.08879391
67AKT31.06714328
68STK161.06028264
69ALK1.05932783
70ATR1.04449199
71PLK41.01049566
72KIT1.00880201
73NEK60.99750734
74RPS6KA20.99725560
75SRPK10.97812414
76MAP3K40.96118414
77AURKB0.95273107
78MAP3K80.95236368
79DAPK20.91540221
80CDK80.91455482
81CDK40.90439746
82MAPKAPK50.90184529
83SGK2230.83382790
84SGK4940.83382790
85SYK0.82000611
86BRAF0.81847721
87CAMK2B0.81839200
88CHEK10.81244535
89STK240.80994991
90CDK70.79537599
91MAPK120.78369260
92MAP3K130.78066191
93FGFR20.77049949
94GRK10.76195219
95PLK10.76032555
96ROCK20.75915630
97PRKCE0.75685995
98YES10.72892544
99NUAK10.72751915
100RPS6KL10.72750344
101RPS6KC10.72750344
102EIF2AK20.72447748
103PLK30.71959636
104RPS6KB20.70659118
105TESK20.69875185
106CCNB10.69673742
107DAPK10.68376875
108INSRR0.67385293
109MAPK70.66474130
110FES0.65836954
111SGK10.65519262
112PIK3CG0.63848884
113TSSK60.63517069
114NEK20.61561988
115EIF2AK30.61373189
116ADRBK20.60424368
117KDR0.60152483
118ARAF0.58742056
119PLK20.57393832
120TBK10.57347827
121CDK50.54343950
122PIM10.54329933
123LYN0.53395701
124TAOK20.53165573
125MAPK40.52397672
126IKBKB0.52010099
127DYRK20.51766728
128PRKCQ0.50991574
129PRKCI0.50420573
130IKBKE0.49998705
131STK100.49587671
132CSNK1G30.49105481
133STK110.48793547
134CDK90.48514389
135PBK0.48009451
136FGFR40.47889907
137RPS6KA60.47529343
138MAPK90.47451418
139IRAK30.47427573
140CDK20.47104893
141FLT30.46421136
142PRKG10.44893264
143MAPK110.44048919
144CSNK2A20.43787843
145ROCK10.43207322
146PRKACA0.43186181
147ATM0.42698930
148CAMK1G0.42358029
149PRKCA0.41873319
150MINK10.41287993
151WEE10.40603139
152ACVR1B0.40382219
153CSNK1A1L0.38573897
154PRKCB0.37547104
155EPHB20.36934084
156GSK3A0.36584416
157AKT20.34893907
158CAMK1D0.34243925
159PIM20.31918144
160CDK10.31477453
161TRIM280.30868343
162LIMK10.30726688
163CSNK1G10.29568450
164PDGFRA0.28403258
165CDK180.27539046
166CDK150.27153140
167CDK11A0.25986092
168CAMK2G0.25926026
169MELK0.25460421
170CSNK1D0.25254881
171PRKDC0.25226742
172RAF10.25222824
173ZAK0.25219567
174SGK20.25127203
175FGR0.24051829

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050335.41913661
2DNA replication_Homo sapiens_hsa030303.58189788
3Serotonergic synapse_Homo sapiens_hsa047262.92328907
4Mismatch repair_Homo sapiens_hsa034302.87559031
5Primary immunodeficiency_Homo sapiens_hsa053402.83631869
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.77889011
7Allograft rejection_Homo sapiens_hsa053302.67767232
8Oxidative phosphorylation_Homo sapiens_hsa001902.64313656
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.54265438
10Spliceosome_Homo sapiens_hsa030402.50899217
11Asthma_Homo sapiens_hsa053102.49774311
12Autoimmune thyroid disease_Homo sapiens_hsa053202.40291621
13Base excision repair_Homo sapiens_hsa034102.39604125
14Synaptic vesicle cycle_Homo sapiens_hsa047212.38353895
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31692669
16Morphine addiction_Homo sapiens_hsa050322.27375431
17Glutamatergic synapse_Homo sapiens_hsa047242.27334295
18Collecting duct acid secretion_Homo sapiens_hsa049662.26399163
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.24681434
20GABAergic synapse_Homo sapiens_hsa047272.22089091
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14200670
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.07798088
23Type I diabetes mellitus_Homo sapiens_hsa049402.05325035
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.02652255
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01805424
26Taste transduction_Homo sapiens_hsa047422.01274253
27Sphingolipid metabolism_Homo sapiens_hsa006002.00909723
28Proteasome_Homo sapiens_hsa030502.00720174
29Axon guidance_Homo sapiens_hsa043601.97281238
30Long-term depression_Homo sapiens_hsa047301.91335066
31Salivary secretion_Homo sapiens_hsa049701.88538846
32Sulfur relay system_Homo sapiens_hsa041221.84333391
33Viral myocarditis_Homo sapiens_hsa054161.81536660
34Non-homologous end-joining_Homo sapiens_hsa034501.72055534
35RNA transport_Homo sapiens_hsa030131.69177609
36Homologous recombination_Homo sapiens_hsa034401.68407923
37Parkinsons disease_Homo sapiens_hsa050121.66688336
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66588236
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66422055
40Circadian entrainment_Homo sapiens_hsa047131.64661164
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.63605821
42B cell receptor signaling pathway_Homo sapiens_hsa046621.62208247
43Alzheimers disease_Homo sapiens_hsa050101.59324073
44Viral carcinogenesis_Homo sapiens_hsa052031.58970598
45Cardiac muscle contraction_Homo sapiens_hsa042601.58960490
46Amphetamine addiction_Homo sapiens_hsa050311.56055602
47Epstein-Barr virus infection_Homo sapiens_hsa051691.51094172
48Herpes simplex infection_Homo sapiens_hsa051681.48692624
49Cocaine addiction_Homo sapiens_hsa050301.46825062
50Nucleotide excision repair_Homo sapiens_hsa034201.46342105
51Vibrio cholerae infection_Homo sapiens_hsa051101.45647193
52Cell cycle_Homo sapiens_hsa041101.44027571
53Gastric acid secretion_Homo sapiens_hsa049711.40673860
54Gap junction_Homo sapiens_hsa045401.40317062
55Antigen processing and presentation_Homo sapiens_hsa046121.39578282
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38558848
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.36526916
58mRNA surveillance pathway_Homo sapiens_hsa030151.33550553
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.33377654
60One carbon pool by folate_Homo sapiens_hsa006701.32512124
61Pyrimidine metabolism_Homo sapiens_hsa002401.30052414
62Biosynthesis of amino acids_Homo sapiens_hsa012301.27389589
63Huntingtons disease_Homo sapiens_hsa050161.26193406
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23456816
65Dopaminergic synapse_Homo sapiens_hsa047281.23382830
66Olfactory transduction_Homo sapiens_hsa047401.20614338
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18984032
68Insulin secretion_Homo sapiens_hsa049111.15963666
69Fanconi anemia pathway_Homo sapiens_hsa034601.13297053
70Renin secretion_Homo sapiens_hsa049241.06446072
71Arginine and proline metabolism_Homo sapiens_hsa003301.05004626
72RNA degradation_Homo sapiens_hsa030181.04956205
73Alcoholism_Homo sapiens_hsa050341.03690416
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99560454
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99514958
76Leishmaniasis_Homo sapiens_hsa051400.99057706
77Long-term potentiation_Homo sapiens_hsa047200.98311559
78Choline metabolism in cancer_Homo sapiens_hsa052310.97883690
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.96689143
80Carbon metabolism_Homo sapiens_hsa012000.96131844
81Vitamin digestion and absorption_Homo sapiens_hsa049770.92428281
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92365882
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90344660
84Protein export_Homo sapiens_hsa030600.89868637
85Influenza A_Homo sapiens_hsa051640.89792576
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88804694
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88449211
88Calcium signaling pathway_Homo sapiens_hsa040200.87153273
89Oxytocin signaling pathway_Homo sapiens_hsa049210.86037323
90Butanoate metabolism_Homo sapiens_hsa006500.85958157
91p53 signaling pathway_Homo sapiens_hsa041150.84941986
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83580868
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.81645112
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81049200
95RNA polymerase_Homo sapiens_hsa030200.80573977
96Basal transcription factors_Homo sapiens_hsa030220.79583344
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.78869916
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76232999
99Pyruvate metabolism_Homo sapiens_hsa006200.74404301
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74288907
101Phagosome_Homo sapiens_hsa041450.73990994
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.73813225
103Melanogenesis_Homo sapiens_hsa049160.73269275
104HTLV-I infection_Homo sapiens_hsa051660.71948969
105Rheumatoid arthritis_Homo sapiens_hsa053230.70809500
106Cholinergic synapse_Homo sapiens_hsa047250.70669071
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69888938
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69687320
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69561207
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69357974
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68424157
112Purine metabolism_Homo sapiens_hsa002300.67524435
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61784823
114Pentose phosphate pathway_Homo sapiens_hsa000300.61132129
115Phenylalanine metabolism_Homo sapiens_hsa003600.60261636
116Apoptosis_Homo sapiens_hsa042100.58536576
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58404164
118Measles_Homo sapiens_hsa051620.58104550
119Mineral absorption_Homo sapiens_hsa049780.57818979
120Vitamin B6 metabolism_Homo sapiens_hsa007500.57437719
121Selenocompound metabolism_Homo sapiens_hsa004500.57187884
122Melanoma_Homo sapiens_hsa052180.53014619
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52890975
124Bile secretion_Homo sapiens_hsa049760.51960471
125Hepatitis B_Homo sapiens_hsa051610.50650300
126cAMP signaling pathway_Homo sapiens_hsa040240.48388627
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.46960008
128Graft-versus-host disease_Homo sapiens_hsa053320.46952298
129Glioma_Homo sapiens_hsa052140.46244193
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.46110982
131ErbB signaling pathway_Homo sapiens_hsa040120.45109025
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44728939
133Thyroid hormone synthesis_Homo sapiens_hsa049180.43445756
134Fructose and mannose metabolism_Homo sapiens_hsa000510.41870209
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41503730
136Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40332559
137Oocyte meiosis_Homo sapiens_hsa041140.39973929
138MAPK signaling pathway_Homo sapiens_hsa040100.39772151
139GnRH signaling pathway_Homo sapiens_hsa049120.39732273
140Type II diabetes mellitus_Homo sapiens_hsa049300.39703883
141African trypanosomiasis_Homo sapiens_hsa051430.39560860
142Dilated cardiomyopathy_Homo sapiens_hsa054140.38918097
143Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38426810
144Inositol phosphate metabolism_Homo sapiens_hsa005620.38000017
145Phototransduction_Homo sapiens_hsa047440.37740193
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37128767
1472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36727211
148Renal cell carcinoma_Homo sapiens_hsa052110.36112561
149Systemic lupus erythematosus_Homo sapiens_hsa053220.35619785
150Toxoplasmosis_Homo sapiens_hsa051450.35140969
151Glycerolipid metabolism_Homo sapiens_hsa005610.34883991
152Metabolic pathways_Homo sapiens_hsa011000.33506020
153Wnt signaling pathway_Homo sapiens_hsa043100.33398991
154Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31620782
155Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31224245
156Staphylococcus aureus infection_Homo sapiens_hsa051500.31125714
157Tyrosine metabolism_Homo sapiens_hsa003500.30426994
158Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28781510
159Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28701442
160Shigellosis_Homo sapiens_hsa051310.28146610
161Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27658603
162cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27450801
163Lysine degradation_Homo sapiens_hsa003100.27427508
164Ribosome_Homo sapiens_hsa030100.26744552
165Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25698389
166Bladder cancer_Homo sapiens_hsa052190.25544027
167Tuberculosis_Homo sapiens_hsa051520.25339821
168Ovarian steroidogenesis_Homo sapiens_hsa049130.25238687
169Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22392819
170Colorectal cancer_Homo sapiens_hsa052100.21145123
171Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20409327
172Hematopoietic cell lineage_Homo sapiens_hsa046400.18846424
173N-Glycan biosynthesis_Homo sapiens_hsa005100.15884204
174Galactose metabolism_Homo sapiens_hsa000520.13919440
175Acute myeloid leukemia_Homo sapiens_hsa052210.11406544
176RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10662237
177Renin-angiotensin system_Homo sapiens_hsa046140.10098853
178Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.06477844

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