HN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microtubule depolymerization (GO:0007019)4.80520803
2establishment of mitochondrion localization (GO:0051654)4.58712664
3pyrimidine nucleobase catabolic process (GO:0006208)4.15001026
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.00237220
5ribosomal small subunit assembly (GO:0000028)3.95387089
6sequestering of actin monomers (GO:0042989)3.94933639
7positive regulation of mitochondrial fission (GO:0090141)3.84727321
8negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74410445
9negative regulation of microtubule polymerization (GO:0031115)3.65666125
10cell migration in hindbrain (GO:0021535)3.65311730
11viral transcription (GO:0019083)3.63786830
12kinetochore organization (GO:0051383)3.63690410
13anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.60556682
14kinetochore assembly (GO:0051382)3.60342828
15ATP synthesis coupled proton transport (GO:0015986)3.58832715
16energy coupled proton transport, down electrochemical gradient (GO:0015985)3.58832715
17regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.57762873
18maturation of SSU-rRNA (GO:0030490)3.57747125
19positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.57515016
20behavioral response to nicotine (GO:0035095)3.56504657
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.50230474
22translational termination (GO:0006415)3.47219775
23ribosomal small subunit biogenesis (GO:0042274)3.45200175
24neuron cell-cell adhesion (GO:0007158)3.44418113
25negative regulation of ligase activity (GO:0051352)3.41434996
26negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.41434996
27spliceosomal snRNP assembly (GO:0000387)3.39369153
28mitotic metaphase plate congression (GO:0007080)3.36782503
29establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.34908202
30mitochondrion transport along microtubule (GO:0047497)3.34908202
31DNA damage response, detection of DNA damage (GO:0042769)3.33371252
32protein insertion into membrane (GO:0051205)3.23648615
33ribosomal large subunit biogenesis (GO:0042273)3.23030042
34protein localization to kinetochore (GO:0034501)3.20097299
35de novo posttranslational protein folding (GO:0051084)3.19190191
36viral protein processing (GO:0019082)3.18994299
37histone H2A acetylation (GO:0043968)3.16452017
38establishment of integrated proviral latency (GO:0075713)3.15452817
39DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.14584250
40protein localization to synapse (GO:0035418)3.14073335
41mitotic sister chromatid segregation (GO:0000070)3.13653811
42viral mRNA export from host cell nucleus (GO:0046784)3.12967193
43CENP-A containing nucleosome assembly (GO:0034080)3.10860405
44translational elongation (GO:0006414)3.10059319
45cellular protein complex disassembly (GO:0043624)3.09845203
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.09434450
47signal transduction involved in cell cycle checkpoint (GO:0072395)3.09017391
48postsynaptic membrane organization (GO:0001941)3.08801351
49positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.08665358
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.07289073
51neuron recognition (GO:0008038)3.06768254
52presynaptic membrane assembly (GO:0097105)3.06272767
53intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06186969
54signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06186969
55ribonucleoprotein complex disassembly (GO:0032988)3.05920369
56viral life cycle (GO:0019058)3.05878223
57telomere maintenance via semi-conservative replication (GO:0032201)3.05109501
58signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05091468
59signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05091468
60signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05091468
61spindle assembly checkpoint (GO:0071173)3.04387328
62negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03946382
63negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03946382
64negative regulation of sister chromatid segregation (GO:0033046)3.03946382
65negative regulation of mitotic sister chromatid separation (GO:2000816)3.03946382
66DNA strand elongation involved in DNA replication (GO:0006271)3.03819080
67mitotic spindle assembly checkpoint (GO:0007094)3.03638123
68protein localization to chromosome, centromeric region (GO:0071459)3.03306921
69protein complex disassembly (GO:0043241)3.03263494
70DNA deamination (GO:0045006)3.02497421
71chromatin remodeling at centromere (GO:0031055)3.02202873
72spindle checkpoint (GO:0031577)3.01792527
73axonal fasciculation (GO:0007413)3.01419159
74sister chromatid segregation (GO:0000819)3.00871788
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.99529347
76proteasome assembly (GO:0043248)2.99434493
77spliceosomal complex assembly (GO:0000245)2.99126740
78protein-DNA complex disassembly (GO:0032986)2.98924751
79nucleosome disassembly (GO:0006337)2.98924751
80translational initiation (GO:0006413)2.98847620
81de novo protein folding (GO:0006458)2.98142690
82negative regulation of chromosome segregation (GO:0051985)2.98070614
83presynaptic membrane organization (GO:0097090)2.98034001
84peptidyl-arginine omega-N-methylation (GO:0035247)2.97483024
85signal transduction involved in DNA damage checkpoint (GO:0072422)2.97243511
86signal transduction involved in DNA integrity checkpoint (GO:0072401)2.97243511
87activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.95166587
88DNA replication-independent nucleosome organization (GO:0034724)2.94522885
89DNA replication-independent nucleosome assembly (GO:0006336)2.94522885
90negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94402818
91cullin deneddylation (GO:0010388)2.93968236
92mitochondrial respiratory chain complex I assembly (GO:0032981)2.93881610
93NADH dehydrogenase complex assembly (GO:0010257)2.93881610
94mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93881610
95establishment of chromosome localization (GO:0051303)2.93004706
96termination of RNA polymerase III transcription (GO:0006386)2.91948070
97transcription elongation from RNA polymerase III promoter (GO:0006385)2.91948070
98substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.91832374
99substrate-independent telencephalic tangential migration (GO:0021826)2.91832374
100attachment of spindle microtubules to kinetochore (GO:0008608)2.90801491
101macromolecular complex disassembly (GO:0032984)2.90208685
102DNA strand elongation (GO:0022616)2.89664144
103mitotic spindle checkpoint (GO:0071174)2.89342988
104neurofilament cytoskeleton organization (GO:0060052)2.89319799
105positive regulation of ligase activity (GO:0051351)2.88782341
106protein complex biogenesis (GO:0070271)2.88538769
107mitotic recombination (GO:0006312)2.86385837
108nucleobase catabolic process (GO:0046113)2.86073909
109protein-cofactor linkage (GO:0018065)2.85701844
110pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.85556542
111respiratory electron transport chain (GO:0022904)2.84935216
112telomere maintenance via recombination (GO:0000722)2.84636196
113hippocampus development (GO:0021766)2.82953976
114metaphase plate congression (GO:0051310)2.82925413
115chaperone-mediated protein transport (GO:0072321)2.82362154
116regulation of protein heterodimerization activity (GO:0043497)2.81104633
117regulation of ubiquitin-protein transferase activity (GO:0051438)2.80129106
118SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.80105984
119gamma-aminobutyric acid transport (GO:0015812)2.79989897
120electron transport chain (GO:0022900)2.79941848
121establishment of viral latency (GO:0019043)2.79072220
122negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79061646
1237-methylguanosine mRNA capping (GO:0006370)2.78894057
124formation of translation preinitiation complex (GO:0001731)2.78303861
125protein deneddylation (GO:0000338)2.78230346
126DNA double-strand break processing (GO:0000729)2.76338218
127synapse assembly (GO:0007416)2.76236904
128organelle disassembly (GO:1903008)2.75419940
1297-methylguanosine RNA capping (GO:0009452)2.75381634
130RNA capping (GO:0036260)2.75381634
131histone arginine methylation (GO:0034969)2.74682383
132negative regulation of RNA splicing (GO:0033119)2.74566479
133retinal ganglion cell axon guidance (GO:0031290)2.74309126
134peptidyl-arginine N-methylation (GO:0035246)2.73913885
135peptidyl-arginine methylation (GO:0018216)2.73913885
136mitochondrial respiratory chain complex assembly (GO:0033108)2.73662264
137cotranslational protein targeting to membrane (GO:0006613)2.73604474
138regulation of cellular amino acid metabolic process (GO:0006521)2.72897618
139ATP-dependent chromatin remodeling (GO:0043044)2.71237964
140protein polyglutamylation (GO:0018095)2.70765951
141RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68414597
142tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68414597
143regulation of mitochondrial translation (GO:0070129)2.67826416
144protein neddylation (GO:0045116)2.66956427
145regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.65870121
146vocalization behavior (GO:0071625)2.65049126
147nonmotile primary cilium assembly (GO:0035058)2.53801340
148protein localization to mitochondrion (GO:0070585)2.53066317
149ganglion development (GO:0061548)2.52873955
150positive regulation of synapse assembly (GO:0051965)2.52468641
151ubiquinone metabolic process (GO:0006743)2.51778019
152establishment of protein localization to mitochondrion (GO:0072655)2.48835576
153negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.48563261
154metallo-sulfur cluster assembly (GO:0031163)2.46661574
155iron-sulfur cluster assembly (GO:0016226)2.46661574
156calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.46156086
157protein targeting to mitochondrion (GO:0006626)2.44558460
158negative regulation of telomere maintenance (GO:0032205)2.44039668
159regulation of mitochondrial fission (GO:0090140)2.44035647
160negative regulation of oligodendrocyte differentiation (GO:0048715)2.42964304
161regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.41561041
162regulation of synapse structural plasticity (GO:0051823)2.40782028
163forebrain neuron differentiation (GO:0021879)2.35745888
164cytoskeleton-dependent intracellular transport (GO:0030705)2.34925582
165sympathetic nervous system development (GO:0048485)2.33586534
166olfactory bulb development (GO:0021772)2.33120270
167regulation of feeding behavior (GO:0060259)2.30422885
168base-excision repair, AP site formation (GO:0006285)2.29976308
169anterograde axon cargo transport (GO:0008089)2.28729646
170GTP biosynthetic process (GO:0006183)2.28092722
171glycosphingolipid biosynthetic process (GO:0006688)2.27970365
172axon extension (GO:0048675)2.27497934
173limb bud formation (GO:0060174)2.26265435
174neurotransmitter-gated ion channel clustering (GO:0072578)2.25661698
175ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.25653098
176nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.25237815

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.87760561
2* FOXM1_23109430_ChIP-Seq_U2OS_Human4.73603885
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.70658407
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.47692659
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.47068354
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.42766158
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.25643288
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.25332107
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.24269870
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.15560346
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.00591928
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.98090549
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92637099
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.88260891
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.81101614
16* XRN2_22483619_ChIP-Seq_HELA_Human2.67494598
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61797680
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60605710
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56595971
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43579977
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.43055780
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34979630
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.34452972
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30480768
25RBPJ_22232070_ChIP-Seq_NCS_Mouse2.30423789
26ZNF274_21170338_ChIP-Seq_K562_Hela2.29955088
27* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27614741
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19541220
29YY1_21170310_ChIP-Seq_MESCs_Mouse2.13708719
30* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12215389
31* TTF2_22483619_ChIP-Seq_HELA_Human2.11923250
32* VDR_23849224_ChIP-Seq_CD4+_Human2.11894884
33IGF1R_20145208_ChIP-Seq_DFB_Human2.09310484
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08873731
35THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06073924
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01412128
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00817127
38CIITA_25753668_ChIP-Seq_RAJI_Human2.00761654
39* DCP1A_22483619_ChIP-Seq_HELA_Human1.98812933
40EZH2_22144423_ChIP-Seq_EOC_Human1.90954564
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.88118067
42FOXP3_21729870_ChIP-Seq_TREG_Human1.83394100
43GABP_19822575_ChIP-Seq_HepG2_Human1.81494154
44ELK1_19687146_ChIP-ChIP_HELA_Human1.75332799
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.74377155
46* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74288096
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70949412
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.70748788
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.65294577
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59918628
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59400295
52KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.59396355
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.58496539
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56879430
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.54043232
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49891704
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48387643
58REST_21632747_ChIP-Seq_MESCs_Mouse1.47789677
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45259114
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44758391
61RNF2_27304074_Chip-Seq_NSC_Mouse1.41749168
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.40374320
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38095104
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36565565
65IRF1_19129219_ChIP-ChIP_H3396_Human1.34474540
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33869629
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33123589
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33092846
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31596480
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.31212899
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27053324
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26642143
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23325507
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21174061
75MYC_18940864_ChIP-ChIP_HL60_Human1.16792511
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16439767
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16356542
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.16198973
79KDM5A_27292631_Chip-Seq_BREAST_Human1.15579796
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14627146
81EED_16625203_ChIP-ChIP_MESCs_Mouse1.13899706
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12626908
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12445684
84* SOX2_16153702_ChIP-ChIP_HESCs_Human1.08551499
85GATA1_26923725_Chip-Seq_HPCs_Mouse1.04493906
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04312563
87MYC_22102868_ChIP-Seq_BL_Human1.02334999
88SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00828769
89* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00073382
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98847629
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97612923
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97337546
93ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96969806
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96940664
95* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96857673
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95667305
97TAF15_26573619_Chip-Seq_HEK293_Human0.95259936
98* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93946952
99VDR_22108803_ChIP-Seq_LS180_Human0.93803267
100FUS_26573619_Chip-Seq_HEK293_Human0.93468126
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93042373
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92401730
103AR_21909140_ChIP-Seq_LNCAP_Human0.90851896
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89774967
105CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89174033
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88963452
107EWS_26573619_Chip-Seq_HEK293_Human0.88901037
108PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88756098
109* NANOG_16153702_ChIP-ChIP_HESCs_Human0.88353502
110GBX2_23144817_ChIP-Seq_PC3_Human0.87549310
111SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87525346
112CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86953959
113ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85896828
114FOXP1_21924763_ChIP-Seq_HESCs_Human0.85215166
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84933720
116TP53_22573176_ChIP-Seq_HFKS_Human0.84823130
117EZH2_27294783_Chip-Seq_ESCs_Mouse0.84715334
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84009750
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83442120
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82253322
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81794527
122YY1_22570637_ChIP-Seq_MALME-3M_Human0.80878084
123VDR_21846776_ChIP-Seq_THP-1_Human0.79944819
124OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79323840
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.78620644
126SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.78433605
127* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77808777
128IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.77117907
129EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.76735696
130BMI1_23680149_ChIP-Seq_NPCS_Mouse0.76680074
131CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.76614542
132NANOG_21062744_ChIP-ChIP_HESCs_Human0.76401761

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.19640719
2MP0006292_abnormal_olfactory_placode3.14161518
3MP0002822_catalepsy3.06699772
4MP0003077_abnormal_cell_cycle2.99954752
5MP0003111_abnormal_nucleus_morphology2.99709014
6MP0010094_abnormal_chromosome_stability2.89939678
7MP0002102_abnormal_ear_morphology2.73225368
8MP0008058_abnormal_DNA_repair2.69463822
9MP0008789_abnormal_olfactory_epithelium2.50438274
10MP0004957_abnormal_blastocyst_morpholog2.46462427
11MP0009379_abnormal_foot_pigmentation2.44002978
12MP0004270_analgesia2.37725075
13MP0006276_abnormal_autonomic_nervous2.34822549
14MP0004859_abnormal_synaptic_plasticity2.31230178
15MP0008007_abnormal_cellular_replicative2.17132980
16MP0008932_abnormal_embryonic_tissue2.15717585
17MP0003315_abnormal_perineum_morphology1.99938493
18MP0010030_abnormal_orbit_morphology1.93623731
19MP0005394_taste/olfaction_phenotype1.85254013
20MP0005499_abnormal_olfactory_system1.85254013
21MP0002751_abnormal_autonomic_nervous1.82710537
22MP0000569_abnormal_digit_pigmentation1.80367486
23MP0000778_abnormal_nervous_system1.79693641
24MP0003121_genomic_imprinting1.79674817
25MP0001529_abnormal_vocalization1.73793651
26MP0003635_abnormal_synaptic_transmissio1.71766347
27MP0002938_white_spotting1.67295399
28MP0003122_maternal_imprinting1.58278837
29MP0000955_abnormal_spinal_cord1.58027968
30MP0002736_abnormal_nociception_after1.55691604
31MP0001968_abnormal_touch/_nociception1.55079582
32MP0003786_premature_aging1.53697885
33MP0004142_abnormal_muscle_tone1.52737606
34MP0002735_abnormal_chemical_nociception1.52012916
35MP0002063_abnormal_learning/memory/cond1.50069444
36MP0002734_abnormal_mechanical_nocicepti1.49599273
37MP0000015_abnormal_ear_pigmentation1.49088740
38MP0002572_abnormal_emotion/affect_behav1.45549755
39MP0009046_muscle_twitch1.45119897
40MP0001905_abnormal_dopamine_level1.44992874
41MP0002234_abnormal_pharynx_morphology1.44043937
42MP0009745_abnormal_behavioral_response1.42338043
43MP0002557_abnormal_social/conspecific_i1.40634819
44MP0008057_abnormal_DNA_replication1.40622430
45MP0000350_abnormal_cell_proliferation1.39808324
46MP0000049_abnormal_middle_ear1.38174308
47MP0002132_abnormal_respiratory_system1.36520424
48MP0002882_abnormal_neuron_morphology1.34973397
49MP0002272_abnormal_nervous_system1.33262139
50MP0005423_abnormal_somatic_nervous1.30768583
51MP0000537_abnormal_urethra_morphology1.30390660
52MP0002184_abnormal_innervation1.27723153
53MP0000490_abnormal_crypts_of1.27370212
54MP0008877_abnormal_DNA_methylation1.25505962
55MP0001730_embryonic_growth_arrest1.25416314
56MP0008995_early_reproductive_senescence1.24206099
57MP0003861_abnormal_nervous_system1.24076998
58MP0003787_abnormal_imprinting1.23306775
59MP0002752_abnormal_somatic_nervous1.23253587
60MP0003890_abnormal_embryonic-extraembry1.22405206
61MP0009333_abnormal_splenocyte_physiolog1.20985517
62MP0003938_abnormal_ear_development1.18068869
63MP0002163_abnormal_gland_morphology1.18066973
64MP0000566_synostosis1.17848931
65MP0002733_abnormal_thermal_nociception1.17371217
66MP0006035_abnormal_mitochondrial_morpho1.16201151
67MP0002152_abnormal_brain_morphology1.15100798
68MP0005174_abnormal_tail_pigmentation1.15060482
69MP0002064_seizures1.13676994
70MP0002067_abnormal_sensory_capabilities1.13619246
71MP0001486_abnormal_startle_reflex1.13294819
72MP0004924_abnormal_behavior1.12794078
73MP0005386_behavior/neurological_phenoty1.12794078
74MP0002282_abnormal_trachea_morphology1.12723373
75MP0003763_abnormal_thymus_physiology1.11960685
76MP0005187_abnormal_penis_morphology1.11086676
77MP0006072_abnormal_retinal_apoptosis1.10288126
78MP0005377_hearing/vestibular/ear_phenot1.08893018
79MP0003878_abnormal_ear_physiology1.08893018
80MP0004742_abnormal_vestibular_system1.07982037
81MP0001970_abnormal_pain_threshold1.07654021
82MP0003718_maternal_effect1.07341223
83MP0003385_abnormal_body_wall1.07031167
84MP0000313_abnormal_cell_death1.05683957
85MP0003119_abnormal_digestive_system1.05534226
86MP0005084_abnormal_gallbladder_morpholo1.05346614
87MP0003937_abnormal_limbs/digits/tail_de1.04239961
88MP0002638_abnormal_pupillary_reflex1.03942895
89MP0003011_delayed_dark_adaptation1.01574524
90MP0000647_abnormal_sebaceous_gland1.00437532
91MP0005253_abnormal_eye_physiology1.00004180
92MP0000750_abnormal_muscle_regeneration0.99945331
93MP0005645_abnormal_hypothalamus_physiol0.99446191
94MP0002210_abnormal_sex_determination0.99182535
95MP0001835_abnormal_antigen_presentation0.97862853
96MP0009053_abnormal_anal_canal0.97249141
97MP0001286_abnormal_eye_development0.96100031
98MP0003123_paternal_imprinting0.95032541
99MP0002085_abnormal_embryonic_tissue0.94679815
100MP0001986_abnormal_taste_sensitivity0.94631067
101MP0002095_abnormal_skin_pigmentation0.92182325
102MP0002398_abnormal_bone_marrow0.91927531
103MP0001697_abnormal_embryo_size0.91555039
104MP0002066_abnormal_motor_capabilities/c0.89791443
105MP0002653_abnormal_ependyma_morphology0.89366324
106MP0002160_abnormal_reproductive_system0.88119913
107MP0001984_abnormal_olfaction0.87295441
108MP0004133_heterotaxia0.86763355
109MP0000372_irregular_coat_pigmentation0.86744817
110MP0002277_abnormal_respiratory_mucosa0.86342442
111MP0002909_abnormal_adrenal_gland0.85627149
112MP0003755_abnormal_palate_morphology0.85053432
113MP0000703_abnormal_thymus_morphology0.84820146
114MP0002080_prenatal_lethality0.84699825
115MP0002069_abnormal_eating/drinking_beha0.84613331
116MP0001299_abnormal_eye_distance/0.82713072
117MP0004811_abnormal_neuron_physiology0.82700774
118MP0002697_abnormal_eye_size0.82696802
119MP0003942_abnormal_urinary_system0.82457412
120MP0003880_abnormal_central_pattern0.81361161
121MP0009785_altered_susceptibility_to0.80904126
122MP0002019_abnormal_tumor_incidence0.80811350
123MP0005195_abnormal_posterior_eye0.80278996
124MP0002081_perinatal_lethality0.80181538
125MP0005391_vision/eye_phenotype0.79801638
126MP0001727_abnormal_embryo_implantation0.79246661
127MP0003567_abnormal_fetal_cardiomyocyte0.78794378
128MP0000631_abnormal_neuroendocrine_gland0.78769214
129MP0001188_hyperpigmentation0.77542044
130MP0001672_abnormal_embryogenesis/_devel0.77503293
131MP0005380_embryogenesis_phenotype0.77503293
132MP0001293_anophthalmia0.77421906
133MP0000858_altered_metastatic_potential0.77323551
134MP0005551_abnormal_eye_electrophysiolog0.75624139
135MP0004808_abnormal_hematopoietic_stem0.73204730
136MP0002116_abnormal_craniofacial_bone0.72568150
137MP0002177_abnormal_outer_ear0.71671798
138MP0000026_abnormal_inner_ear0.70500089
139MP0001119_abnormal_female_reproductive0.69840280
140MP0002233_abnormal_nose_morphology0.69173987
141MP0003221_abnormal_cardiomyocyte_apopto0.67658438
142MP0001145_abnormal_male_reproductive0.66769065
143MP0002396_abnormal_hematopoietic_system0.66432237
144MP0001929_abnormal_gametogenesis0.66272518
145MP0002932_abnormal_joint_morphology0.66204355
146MP0005257_abnormal_intraocular_pressure0.65714293
147MP0005671_abnormal_response_to0.65542616

Predicted human phenotypes

RankGene SetZ-score
1Patellar aplasia (HP:0006443)3.77994355
2Reticulocytopenia (HP:0001896)3.64878804
3Aplasia/Hypoplasia of the patella (HP:0006498)3.57289773
4Retinal dysplasia (HP:0007973)3.40303119
5Myokymia (HP:0002411)3.15268214
6Acute encephalopathy (HP:0006846)3.09203923
7Abnormality of cells of the erythroid lineage (HP:0012130)3.08171545
8Chromosomal breakage induced by crosslinking agents (HP:0003221)2.97736380
9Hepatocellular necrosis (HP:0001404)2.91132708
10Abnormal number of erythroid precursors (HP:0012131)2.90244726
11Abnormality of the intervertebral disk (HP:0005108)2.88044042
12Gait imbalance (HP:0002141)2.86700835
13Increased CSF lactate (HP:0002490)2.76702692
14Wrist flexion contracture (HP:0001239)2.74252180
15Poor suck (HP:0002033)2.69546407
16Chromsome breakage (HP:0040012)2.68729506
17Shoulder girdle muscle weakness (HP:0003547)2.64251160
18Hepatic necrosis (HP:0002605)2.61679204
19Lissencephaly (HP:0001339)2.60815261
20High anterior hairline (HP:0009890)2.60506204
21Abnormality of the preputium (HP:0100587)2.52773942
22Abnormal number of incisors (HP:0011064)2.52595650
23Colon cancer (HP:0003003)2.52130025
24Nephrogenic diabetes insipidus (HP:0009806)2.51196705
25Congenital primary aphakia (HP:0007707)2.49442006
26Medial flaring of the eyebrow (HP:0010747)2.48010285
27Abnormality of the anterior horn cell (HP:0006802)2.47738154
28Degeneration of anterior horn cells (HP:0002398)2.47738154
29Optic nerve coloboma (HP:0000588)2.44445423
30Drooling (HP:0002307)2.38173832
3111 pairs of ribs (HP:0000878)2.37434693
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.36253291
33Meckel diverticulum (HP:0002245)2.35188117
34Abnormality of the labia minora (HP:0012880)2.34086853
35Short 4th metacarpal (HP:0010044)2.32472917
36Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.32472917
37Pelvic girdle muscle weakness (HP:0003749)2.31583163
38Pallor (HP:0000980)2.31220050
39Atrophy/Degeneration involving motor neurons (HP:0007373)2.30987855
40Abnormal lung lobation (HP:0002101)2.29984311
41Birth length less than 3rd percentile (HP:0003561)2.29289789
42Abnormality of the ileum (HP:0001549)2.29245171
43Urinary urgency (HP:0000012)2.27949827
44Lipid accumulation in hepatocytes (HP:0006561)2.21034199
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.17392097
46Cerebral edema (HP:0002181)2.16991294
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.15796029
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.15796029
49Hypoplasia of the brainstem (HP:0002365)2.14246090
50Aplasia/Hypoplasia of the brainstem (HP:0007362)2.14246090
51Acute necrotizing encephalopathy (HP:0006965)2.13651562
52Excessive salivation (HP:0003781)2.12337546
53Specific learning disability (HP:0001328)2.11437905
54Spastic tetraplegia (HP:0002510)2.08887867
55Abnormality of the metopic suture (HP:0005556)2.08441886
56Oral leukoplakia (HP:0002745)2.07251212
57Split foot (HP:0001839)2.06803149
58Abnormal hair whorl (HP:0010721)2.05423895
59Cleft eyelid (HP:0000625)2.04302341
60Esotropia (HP:0000565)2.03936101
61Poikiloderma (HP:0001029)2.03785019
62Abnormality of the corticospinal tract (HP:0002492)2.03420209
63Hypoplastic pelvis (HP:0008839)2.02750484
64Sclerocornea (HP:0000647)2.02552428
65Small intestinal stenosis (HP:0012848)2.02398971
66Duodenal stenosis (HP:0100867)2.02398971
67Amblyopia (HP:0000646)2.02011332
68Hypsarrhythmia (HP:0002521)2.01895681
69Nephroblastoma (Wilms tumor) (HP:0002667)2.01172203
70Cerebral hypomyelination (HP:0006808)2.01072298
71Abnormality of hair growth rate (HP:0011363)1.99993837
72Slow-growing hair (HP:0002217)1.99993837
73Increased serum lactate (HP:0002151)1.99798511
74Abnormality of the hip-girdle musculature (HP:0001445)1.99766615
75Abnormality of the musculature of the pelvis (HP:0001469)1.99766615
76Cortical dysplasia (HP:0002539)1.99271234
77Aplastic anemia (HP:0001915)1.98561120
78Limb dystonia (HP:0002451)1.98366248
79Oligodactyly (hands) (HP:0001180)1.97971745
80Pancreatic cysts (HP:0001737)1.97901730
81Pancreatic fibrosis (HP:0100732)1.97644862
82Polymicrogyria (HP:0002126)1.97454514
83Mitochondrial inheritance (HP:0001427)1.96817202
84Triphalangeal thumb (HP:0001199)1.95980373
85Amyotrophic lateral sclerosis (HP:0007354)1.95706124
86Abnormality of DNA repair (HP:0003254)1.95163385
87Lactic acidosis (HP:0003128)1.94704726
88Increased hepatocellular lipid droplets (HP:0006565)1.94328326
89Vaginal atresia (HP:0000148)1.93266086
903-Methylglutaconic aciduria (HP:0003535)1.93107291
91Embryonal renal neoplasm (HP:0011794)1.93107268
92Medulloblastoma (HP:0002885)1.92913355
93Absent thumb (HP:0009777)1.92653342
94Prominent metopic ridge (HP:0005487)1.92288510
95Optic disc pallor (HP:0000543)1.92194739
96Abnormality of midbrain morphology (HP:0002418)1.91715950
97Molar tooth sign on MRI (HP:0002419)1.91715950
98Genital tract atresia (HP:0001827)1.90116623
99Hyperglycinemia (HP:0002154)1.89728762
100Depressed nasal ridge (HP:0000457)1.88498704
101Tracheoesophageal fistula (HP:0002575)1.88125613
102EEG with generalized epileptiform discharges (HP:0011198)1.87746556
103Aplasia/Hypoplasia of the sternum (HP:0006714)1.87391631
104Horseshoe kidney (HP:0000085)1.85419690
105Broad-based gait (HP:0002136)1.84693369
106Type II lissencephaly (HP:0007260)1.84686426
107Increased nuchal translucency (HP:0010880)1.84550265
108Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84349979
109Abnormality of the carotid arteries (HP:0005344)1.83927162
110Exertional dyspnea (HP:0002875)1.82229707
111Renal Fanconi syndrome (HP:0001994)1.82029983
112Abnormality of the lower motor neuron (HP:0002366)1.80914499
113Trismus (HP:0000211)1.80653204
114Epileptiform EEG discharges (HP:0011182)1.80233428
115Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78215129
116Glossoptosis (HP:0000162)1.78165868
117Macrocytic anemia (HP:0001972)1.78157599
118Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77231794
119Failure to thrive in infancy (HP:0001531)1.77079413
120Abnormal mitochondria in muscle tissue (HP:0008316)1.76529484
121Upper limb muscle weakness (HP:0003484)1.76098015
122Progressive macrocephaly (HP:0004481)1.75203439
123Anencephaly (HP:0002323)1.75140351
124Cerebellar hypoplasia (HP:0001321)1.74668044
125Agitation (HP:0000713)1.74352783
126Hepatoblastoma (HP:0002884)1.74230458
127Breast hypoplasia (HP:0003187)1.73852049
128Pendular nystagmus (HP:0012043)1.73789354
129Rimmed vacuoles (HP:0003805)1.73469700
130Oligodactyly (HP:0012165)1.73446002
131Emotional lability (HP:0000712)1.72403911
132Multiple enchondromatosis (HP:0005701)1.71798929
133Myelodysplasia (HP:0002863)1.71438652
134Heterochromia iridis (HP:0001100)1.71385087
135CNS hypomyelination (HP:0003429)1.71219197
136Leukodystrophy (HP:0002415)1.70804921
137Increased intramyocellular lipid droplets (HP:0012240)1.70683899
138Exercise intolerance (HP:0003546)1.69821482
139Concave nail (HP:0001598)1.67131720
140Proximal placement of thumb (HP:0009623)1.67023615
141Facial hemangioma (HP:0000329)1.66898543
142Polyphagia (HP:0002591)1.66884131
143Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66662303
144Degeneration of the lateral corticospinal tracts (HP:0002314)1.66662303
145Abnormality of glycolysis (HP:0004366)1.65496732
146Increased serum pyruvate (HP:0003542)1.65496732
147Anophthalmia (HP:0000528)1.65334420
148X-linked dominant inheritance (HP:0001423)1.65182633
149Epileptic encephalopathy (HP:0200134)1.65052972
150Abnormality of placental membranes (HP:0011409)1.64761174
151Amniotic constriction ring (HP:0009775)1.64761174
152Neoplasm of the pancreas (HP:0002894)1.62917187
153Rough bone trabeculation (HP:0100670)1.62735582
154Pachygyria (HP:0001302)1.62515008
155True hermaphroditism (HP:0010459)1.62400065
156Thick lower lip vermilion (HP:0000179)1.61769761
157Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.60543616
158Abnormality of chromosome stability (HP:0003220)1.60365748
159Large eyes (HP:0001090)1.60134390
160Preaxial hand polydactyly (HP:0001177)1.60026258
161Spina bifida occulta (HP:0003298)1.59996833
162Short philtrum (HP:0000322)1.59724763
163Respiratory difficulties (HP:0002880)1.59720973
164Increased IgM level (HP:0003496)1.58964570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.32795132
2MARK14.02406974
3DYRK23.46635175
4MAP3K42.98425183
5SRPK12.71925258
6LIMK12.56160526
7STK162.55024521
8DYRK32.36886224
9TRIM282.30287527
10WNK32.30250775
11ERBB32.27429377
12SIK32.20300833
13CCNB12.17949771
14MAPK132.16798941
15TESK12.06114321
16WEE12.02457041
17MAP4K21.96374779
18EIF2AK11.94733595
19TESK21.89536591
20CSNK1G21.89054008
21VRK11.86238373
22INSRR1.85531141
23PIM21.84510314
24CSNK1A1L1.80230944
25CDC71.80129954
26VRK21.77861075
27BRSK11.69950953
28NME21.69649373
29CDK191.67657271
30UHMK11.66323895
31TLK11.54757676
32AURKA1.53803239
33EPHB21.53543796
34NEK21.51706984
35CSNK1G11.51248467
36PLK31.49098493
37PLK11.48873059
38MAP3K121.46740693
39ACVR1B1.45988438
40BCKDK1.37958484
41PLK41.37234921
42AURKB1.33421192
43BMPR1B1.32510469
44MKNK11.28594139
45MAP2K41.26688078
46BRAF1.26137186
47DYRK1B1.25700196
48BCR1.21284883
49EIF2AK21.19548544
50NME11.17230875
51BRSK21.14265141
52KSR11.10671564
53BLK1.10157262
54TGFBR11.00495640
55EPHA40.99084196
56CHEK20.96646684
57IRAK40.96253293
58ATR0.93824794
59PRKCG0.92616362
60YES10.88458802
61RPS6KA40.85759242
62PINK10.84976063
63PAK30.83616226
64SIK20.82801544
65PAK60.82556926
66TTK0.81303853
67NTRK20.80925917
68CASK0.78545832
69TXK0.77172827
70PRKCI0.75461412
71PAK10.74530846
72RPS6KA20.74425752
73MINK10.71942849
74CDK180.71254923
75CDK50.66653401
76NEK10.66338239
77ILK0.66044181
78IRAK20.64758643
79MAP3K60.62403473
80PKN10.61217797
81ZAK0.59993703
82CDK70.58072997
83PHKG10.57712487
84PHKG20.57712487
85CDK150.57645002
86LMTK20.57113534
87EPHA30.56660055
88PBK0.56215133
89CSNK1G30.56026922
90CHEK10.55336628
91MAP3K100.54590250
92CDK11A0.54440075
93MAP2K70.54417019
94CDK140.53839976
95CLK10.52021713
96EPHA20.51666194
97CDK80.51439681
98TAOK20.51320830
99MKNK20.50840907
100CAMK2B0.49543931
101RPS6KC10.48538129
102RPS6KL10.48538129
103DYRK1A0.48333400
104CSNK2A10.47031884
105CSNK1E0.46523545
106TSSK60.44955489
107MAPK40.44765097
108DAPK10.44223980
109SYK0.44156049
110PRKCE0.42479031
111PRKCZ0.42331474
112RPS6KA60.42216106
113CDK10.41782600
114CAMK2A0.41645047
115MAPK90.41230126
116ARAF0.41085809
117EIF2AK30.40616416
118PLK20.40102643
119NTRK10.38766367
120MAPKAPK20.38744015
121PAK40.38599970
122PASK0.38469130
123ERBB20.38099665
124RPS6KA10.37433079
125MAP3K110.36980922
126MAP4K10.34843395
127PDK20.34673312
128CDK20.34149072
129RPS6KA50.33804644
130CSNK1A10.33737071
131MAP3K50.33435403
132CSNK2A20.33089454
133CAMK2G0.32742365
134ADRBK20.32184779
135TNIK0.32101720
136WNK40.31868531
137RPS6KB20.31548327
138MAP3K80.30724905

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.83006702
2Ribosome_Homo sapiens_hsa030103.48555111
3DNA replication_Homo sapiens_hsa030303.20973100
4Spliceosome_Homo sapiens_hsa030403.05082913
5RNA polymerase_Homo sapiens_hsa030203.04009086
6Mismatch repair_Homo sapiens_hsa034302.87855606
7Base excision repair_Homo sapiens_hsa034102.63060403
8Nicotine addiction_Homo sapiens_hsa050332.61921480
9Nucleotide excision repair_Homo sapiens_hsa034202.22104487
10Cell cycle_Homo sapiens_hsa041102.22098954
11Pyrimidine metabolism_Homo sapiens_hsa002402.20555878
12RNA transport_Homo sapiens_hsa030132.18721851
13Homologous recombination_Homo sapiens_hsa034402.17315037
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17065016
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.09573112
16Steroid biosynthesis_Homo sapiens_hsa001002.03746264
17Protein export_Homo sapiens_hsa030602.03008245
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95824421
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.94317836
20Synaptic vesicle cycle_Homo sapiens_hsa047211.91529454
21Sulfur relay system_Homo sapiens_hsa041221.84133182
22Parkinsons disease_Homo sapiens_hsa050121.78375461
23Fanconi anemia pathway_Homo sapiens_hsa034601.75113616
24Basal transcription factors_Homo sapiens_hsa030221.67274883
25mRNA surveillance pathway_Homo sapiens_hsa030151.62058628
26Oxidative phosphorylation_Homo sapiens_hsa001901.61235329
27Huntingtons disease_Homo sapiens_hsa050161.61110469
28GABAergic synapse_Homo sapiens_hsa047271.45753069
29RNA degradation_Homo sapiens_hsa030181.45251419
30Epstein-Barr virus infection_Homo sapiens_hsa051691.44661318
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44525343
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43522424
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41517980
34Vibrio cholerae infection_Homo sapiens_hsa051101.40505114
35Collecting duct acid secretion_Homo sapiens_hsa049661.40233059
36p53 signaling pathway_Homo sapiens_hsa041151.38823279
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35919439
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28343762
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27054784
40Viral myocarditis_Homo sapiens_hsa054161.22606480
41Colorectal cancer_Homo sapiens_hsa052101.21296270
42Biosynthesis of amino acids_Homo sapiens_hsa012301.19094345
43Fatty acid elongation_Homo sapiens_hsa000621.18581122
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16722979
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16004400
46Purine metabolism_Homo sapiens_hsa002301.09608762
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09162021
48Systemic lupus erythematosus_Homo sapiens_hsa053221.09124168
49Oocyte meiosis_Homo sapiens_hsa041141.07855163
50Phototransduction_Homo sapiens_hsa047441.06567402
51Alzheimers disease_Homo sapiens_hsa050101.06566598
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03907561
53Folate biosynthesis_Homo sapiens_hsa007901.01095757
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98519492
55Dopaminergic synapse_Homo sapiens_hsa047280.98287519
56Cocaine addiction_Homo sapiens_hsa050300.98059811
57Herpes simplex infection_Homo sapiens_hsa051680.97370707
58Morphine addiction_Homo sapiens_hsa050320.96075562
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93458645
60Graft-versus-host disease_Homo sapiens_hsa053320.92535175
61Shigellosis_Homo sapiens_hsa051310.91346033
62Allograft rejection_Homo sapiens_hsa053300.90719662
63One carbon pool by folate_Homo sapiens_hsa006700.89534849
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88410956
65Butanoate metabolism_Homo sapiens_hsa006500.87041535
66Regulation of autophagy_Homo sapiens_hsa041400.84896217
67Primary immunodeficiency_Homo sapiens_hsa053400.84570022
68Pyruvate metabolism_Homo sapiens_hsa006200.84119387
69Selenocompound metabolism_Homo sapiens_hsa004500.83468757
70Non-homologous end-joining_Homo sapiens_hsa034500.82811814
71Viral carcinogenesis_Homo sapiens_hsa052030.82740302
72Taste transduction_Homo sapiens_hsa047420.82161643
73Apoptosis_Homo sapiens_hsa042100.81588425
74Legionellosis_Homo sapiens_hsa051340.80998975
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.80113234
76Alcoholism_Homo sapiens_hsa050340.79653172
77Asthma_Homo sapiens_hsa053100.78331481
78Axon guidance_Homo sapiens_hsa043600.76603191
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75976713
80HTLV-I infection_Homo sapiens_hsa051660.75573712
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74192737
82Glutamatergic synapse_Homo sapiens_hsa047240.73335649
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73318699
84Endometrial cancer_Homo sapiens_hsa052130.72846689
85Metabolic pathways_Homo sapiens_hsa011000.70154154
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69450000
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.68431500
88Carbon metabolism_Homo sapiens_hsa012000.68229549
89Influenza A_Homo sapiens_hsa051640.67580144
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65516363
91Cardiac muscle contraction_Homo sapiens_hsa042600.64218786
92Leishmaniasis_Homo sapiens_hsa051400.64152130
93Phagosome_Homo sapiens_hsa041450.63503863
94Measles_Homo sapiens_hsa051620.63000405
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62637368
96MicroRNAs in cancer_Homo sapiens_hsa052060.62612058
97Salmonella infection_Homo sapiens_hsa051320.62097803
98Hepatitis B_Homo sapiens_hsa051610.60967461
99Sulfur metabolism_Homo sapiens_hsa009200.59757501
100T cell receptor signaling pathway_Homo sapiens_hsa046600.59592178
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57791779
102Arginine and proline metabolism_Homo sapiens_hsa003300.57246798
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57061900
104Basal cell carcinoma_Homo sapiens_hsa052170.56769894
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55811000
106Notch signaling pathway_Homo sapiens_hsa043300.54842395
107Antigen processing and presentation_Homo sapiens_hsa046120.54634277
108Circadian entrainment_Homo sapiens_hsa047130.53932774
109Peroxisome_Homo sapiens_hsa041460.51845460
110Autoimmune thyroid disease_Homo sapiens_hsa053200.51612564
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51552156
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.51370894
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50222946
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49768865
115Hippo signaling pathway_Homo sapiens_hsa043900.49156417
116Chronic myeloid leukemia_Homo sapiens_hsa052200.48962635
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48043613
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.47594596
119Pertussis_Homo sapiens_hsa051330.47160624
120Hedgehog signaling pathway_Homo sapiens_hsa043400.46257593
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45867197
122Hematopoietic cell lineage_Homo sapiens_hsa046400.45371730
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43587008
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43506651
125Propanoate metabolism_Homo sapiens_hsa006400.43490228
126Pancreatic cancer_Homo sapiens_hsa052120.42851054
127Amphetamine addiction_Homo sapiens_hsa050310.42802979
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41251787
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40733834
130Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40445919
131N-Glycan biosynthesis_Homo sapiens_hsa005100.40123061
132Fructose and mannose metabolism_Homo sapiens_hsa000510.39103032
133Small cell lung cancer_Homo sapiens_hsa052220.37330933
134Serotonergic synapse_Homo sapiens_hsa047260.36416120
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35770771
136Tuberculosis_Homo sapiens_hsa051520.35507096
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35491354
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35297167
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33891163
140Pathways in cancer_Homo sapiens_hsa052000.33800952
141Thyroid cancer_Homo sapiens_hsa052160.33522304
142Ether lipid metabolism_Homo sapiens_hsa005650.32789103
143VEGF signaling pathway_Homo sapiens_hsa043700.32558253
144Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32386890
145Glutathione metabolism_Homo sapiens_hsa004800.32311995
146Toxoplasmosis_Homo sapiens_hsa051450.31550280
147Gap junction_Homo sapiens_hsa045400.31117581
148Phenylalanine metabolism_Homo sapiens_hsa003600.30921697
149Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30630473
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30402290
151Olfactory transduction_Homo sapiens_hsa047400.30195698
152TNF signaling pathway_Homo sapiens_hsa046680.29771745
153AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29623081
154Type I diabetes mellitus_Homo sapiens_hsa049400.29284715
155Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29199640
156Wnt signaling pathway_Homo sapiens_hsa043100.28618728
157B cell receptor signaling pathway_Homo sapiens_hsa046620.27265523
158Non-small cell lung cancer_Homo sapiens_hsa052230.26896084

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