HNF1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)7.38159440
2urate metabolic process (GO:0046415)7.22433623
3lysine catabolic process (GO:0006554)6.70053882
4lysine metabolic process (GO:0006553)6.70053882
5cysteine metabolic process (GO:0006534)6.68805268
6L-phenylalanine catabolic process (GO:0006559)6.59691916
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.59691916
8L-phenylalanine metabolic process (GO:0006558)6.47192887
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.47192887
10glyoxylate metabolic process (GO:0046487)6.42073841
11drug transport (GO:0015893)6.17739860
12aromatic amino acid family catabolic process (GO:0009074)5.83687594
13drug catabolic process (GO:0042737)5.60807330
14organic cation transport (GO:0015695)5.50846654
15phosphate ion transport (GO:0006817)5.40914256
16aminoglycoside antibiotic metabolic process (GO:0030647)5.29295600
17indole-containing compound catabolic process (GO:0042436)5.18069714
18indolalkylamine catabolic process (GO:0046218)5.18069714
19tryptophan catabolic process (GO:0006569)5.18069714
20exogenous drug catabolic process (GO:0042738)5.08475378
21homocysteine metabolic process (GO:0050667)5.05767640
22sulfur amino acid catabolic process (GO:0000098)5.01774509
23tryptophan metabolic process (GO:0006568)4.98745455
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.94964540
25serine family amino acid catabolic process (GO:0009071)4.86342477
26phosphate ion transmembrane transport (GO:0035435)4.67788034
27aspartate family amino acid catabolic process (GO:0009068)4.67736633
28response to mercury ion (GO:0046689)4.66851046
29cellular modified amino acid catabolic process (GO:0042219)4.63562302
30tricarboxylic acid metabolic process (GO:0072350)4.60685747
31kynurenine metabolic process (GO:0070189)4.57729206
32short-chain fatty acid metabolic process (GO:0046459)4.56396084
33amino-acid betaine metabolic process (GO:0006577)4.53896614
34serine family amino acid metabolic process (GO:0009069)4.45714705
35quaternary ammonium group transport (GO:0015697)4.43034441
36aromatic amino acid family metabolic process (GO:0009072)4.29701054
37high-density lipoprotein particle remodeling (GO:0034375)4.26940420
38valine metabolic process (GO:0006573)4.26135178
39regulation of cholesterol homeostasis (GO:2000188)4.21526089
40cellular ketone body metabolic process (GO:0046950)4.17290501
41branched-chain amino acid metabolic process (GO:0009081)4.15158712
42calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.15076264
43alpha-amino acid catabolic process (GO:1901606)4.09533626
44sulfation (GO:0051923)4.08733288
45fatty acid beta-oxidation (GO:0006635)4.06942820
46cellular amino acid catabolic process (GO:0009063)4.06547548
47bile acid biosynthetic process (GO:0006699)4.04970561
48glutamate metabolic process (GO:0006536)4.01496897
49proline metabolic process (GO:0006560)3.97532378
502-oxoglutarate metabolic process (GO:0006103)3.96840482
51transepithelial transport (GO:0070633)3.93665163
52regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.92330935
53serine family amino acid biosynthetic process (GO:0009070)3.89604934
54fatty acid oxidation (GO:0019395)3.89174022
55reverse cholesterol transport (GO:0043691)3.86244330
56renal absorption (GO:0070293)3.81339998
57lipid oxidation (GO:0034440)3.80257534
58otic vesicle formation (GO:0030916)3.79194580
59indolalkylamine metabolic process (GO:0006586)3.79184284
60nonribosomal peptide biosynthetic process (GO:0019184)3.78373238
61excretion (GO:0007588)3.69948835
62vitamin D metabolic process (GO:0042359)3.68963584
63drug metabolic process (GO:0017144)3.66084407
64carboxylic acid catabolic process (GO:0046395)3.64720392
65organic acid catabolic process (GO:0016054)3.64720392
66branched-chain amino acid catabolic process (GO:0009083)3.64280082
67benzene-containing compound metabolic process (GO:0042537)3.63808508
68fatty acid catabolic process (GO:0009062)3.62242002
69* regulation of apoptotic process involved in morphogenesis (GO:1902337)3.61019852
70acetyl-CoA metabolic process (GO:0006084)3.60688708
71alpha-linolenic acid metabolic process (GO:0036109)3.58869018
72carnitine metabolic process (GO:0009437)3.57952596
73ketone body metabolic process (GO:1902224)3.56234839
74glutathione biosynthetic process (GO:0006750)3.55425037
75regulation of bile acid biosynthetic process (GO:0070857)3.55357261
76monocarboxylic acid catabolic process (GO:0072329)3.52954922
773-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.49752128
78purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.49752128
79amino-acid betaine transport (GO:0015838)3.47185656
80carnitine transport (GO:0015879)3.47185656
81bile acid metabolic process (GO:0008206)3.46691055
82phospholipid efflux (GO:0033700)3.45871276
83water-soluble vitamin biosynthetic process (GO:0042364)3.44460614
84tyrosine metabolic process (GO:0006570)3.42071715
85urea cycle (GO:0000050)3.40937086
86urea metabolic process (GO:0019627)3.40937086
87plasma lipoprotein particle assembly (GO:0034377)3.40567814
88regulation of cholesterol esterification (GO:0010872)3.39604556
89peptide catabolic process (GO:0043171)3.37974103
90aldehyde catabolic process (GO:0046185)3.33332452
91fructose metabolic process (GO:0006000)3.32778482
92cellular biogenic amine catabolic process (GO:0042402)3.31792964
93amine catabolic process (GO:0009310)3.31792964
94phosphate ion homeostasis (GO:0055062)3.28524458
95trivalent inorganic anion homeostasis (GO:0072506)3.28524458
96flavonoid metabolic process (GO:0009812)3.27553027
97cellular glucuronidation (GO:0052695)3.23848708
98glucuronate metabolic process (GO:0019585)3.23249401
99uronic acid metabolic process (GO:0006063)3.23249401
100auditory receptor cell differentiation (GO:0042491)3.22744521
101regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.22258987
102nitrogen cycle metabolic process (GO:0071941)3.21298971
103negative regulation of sterol transport (GO:0032372)3.21205480
104negative regulation of cholesterol transport (GO:0032375)3.21205480
105intestinal cholesterol absorption (GO:0030299)3.21052129
106intestinal absorption (GO:0050892)3.20290920
107glutathione derivative metabolic process (GO:1901685)3.20169542
108glutathione derivative biosynthetic process (GO:1901687)3.20169542
109triglyceride homeostasis (GO:0070328)3.19825457
110acylglycerol homeostasis (GO:0055090)3.19825457
1114-hydroxyproline metabolic process (GO:0019471)3.19799520
112toxin transport (GO:1901998)3.18616770
113metanephric nephron tubule development (GO:0072234)3.17902127
114metanephric tubule development (GO:0072170)3.17902127
115protein carboxylation (GO:0018214)3.15836988
116peptidyl-glutamic acid carboxylation (GO:0017187)3.15836988
117ethanol oxidation (GO:0006069)3.14001499
118indole-containing compound metabolic process (GO:0042430)3.13713385
119glycine metabolic process (GO:0006544)3.12993093
120regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.11803211
121protein K11-linked deubiquitination (GO:0035871)3.10110554
122coenzyme catabolic process (GO:0009109)3.09977304
123response to growth hormone (GO:0060416)3.09890946
124cytidine metabolic process (GO:0046087)3.09817101
125cytidine catabolic process (GO:0006216)3.09817101
126cytidine deamination (GO:0009972)3.09817101
127branching involved in labyrinthine layer morphogenesis (GO:0060670)3.07090156
128protein-lipid complex remodeling (GO:0034368)3.03986940
129macromolecular complex remodeling (GO:0034367)3.03986940
130plasma lipoprotein particle remodeling (GO:0034369)3.03986940
131cobalamin metabolic process (GO:0009235)3.01988519
132regulation of cytokine secretion involved in immune response (GO:0002739)2.96101438
133basic amino acid transport (GO:0015802)2.95923492
134triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.90461110
135phospholipid homeostasis (GO:0055091)2.88796230
136* endocrine pancreas development (GO:0031018)2.88676826
137very-low-density lipoprotein particle assembly (GO:0034379)2.87544420
138protein-lipid complex assembly (GO:0065005)2.84532836
139regulation of glomerulus development (GO:0090192)2.84507376
140regulation of alkaline phosphatase activity (GO:0010692)2.84161602
141positive regulation of digestive system process (GO:0060456)2.82045519
142regulation of glucokinase activity (GO:0033131)2.80552921
143regulation of hexokinase activity (GO:1903299)2.80552921
144cholesterol efflux (GO:0033344)2.79802358
145L-ascorbic acid metabolic process (GO:0019852)2.77006493
146signal transduction involved in regulation of gene expression (GO:0023019)2.75800277
147cellular response to ATP (GO:0071318)2.73406616
148positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.72100156
149regulation of hippo signaling (GO:0035330)2.71940466
150xenobiotic catabolic process (GO:0042178)2.65609600
151metanephric nephron epithelium development (GO:0072243)2.65590956
152positive regulation of glomerulus development (GO:0090193)2.64685077
153regulation of digestive system process (GO:0044058)2.61886029
154ethanol metabolic process (GO:0006067)2.57916201
155positive regulation of metanephros development (GO:0072216)2.57266917
156positive regulation of icosanoid secretion (GO:0032305)2.56325853
157heme transport (GO:0015886)2.55551938
158regulation of triglyceride catabolic process (GO:0010896)2.54257933
159plasma lipoprotein particle organization (GO:0071827)2.53976044
160regulation of protein activation cascade (GO:2000257)2.53717499
161epoxygenase P450 pathway (GO:0019373)2.53651177
162metanephric epithelium development (GO:0072207)2.52374025
163negative regulation of coagulation (GO:0050819)2.51807420
164cholesterol homeostasis (GO:0042632)2.51408228
165cholesterol transport (GO:0030301)2.51405358
166sterol transport (GO:0015918)2.51405358

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.94561189
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.75407515
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.02077577
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.25783699
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.07550706
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.05921337
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.63655049
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.24739606
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.04759551
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.77517302
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.63656598
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.58132915
13CLOCK_20551151_ChIP-Seq_293T_Human2.37658482
14SOX2_27498859_Chip-Seq_STOMACH_Mouse2.34499171
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31134411
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28718478
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.11262616
18GBX2_23144817_ChIP-Seq_PC3_Human2.10455356
19ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.02987400
20GATA4_25053715_ChIP-Seq_YYC3_Human2.01247460
21* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.96309418
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.91575914
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.85226855
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.82497171
25* FOXA2_19822575_ChIP-Seq_HepG2_Human1.82351908
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.78070662
27ZNF274_21170338_ChIP-Seq_K562_Hela1.72749081
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.71197806
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.70877916
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.70192521
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66235381
32GATA1_22025678_ChIP-Seq_K562_Human1.65420842
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64644478
34* HNF4A_19822575_ChIP-Seq_HepG2_Human1.61659007
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.60120327
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59361035
37* GATA6_25053715_ChIP-Seq_YYC3_Human1.58705660
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54688768
39AR_21909140_ChIP-Seq_LNCAP_Human1.51853180
40AHR_22903824_ChIP-Seq_MCF-7_Human1.49197284
41TP53_16413492_ChIP-PET_HCT116_Human1.47445623
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.46181990
43TP53_18474530_ChIP-ChIP_U2OS_Human1.41078199
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40363836
45* SMAD3_21741376_ChIP-Seq_HESCs_Human1.39629613
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.39500244
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39245637
48FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35373587
49* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.35269945
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34399865
51CJUN_26792858_Chip-Seq_BT549_Human1.32829795
52* SMAD4_21741376_ChIP-Seq_HESCs_Human1.30366349
53SMAD4_21741376_ChIP-Seq_EPCs_Human1.29578605
54SOX2_20726797_ChIP-Seq_SW620_Human1.27450865
55VDR_22108803_ChIP-Seq_LS180_Human1.27378389
56* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26626826
57* FOXA1_25329375_ChIP-Seq_VCAP_Human1.26626826
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24931633
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23480642
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23367478
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23232746
62FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22196325
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.21695342
64BCAT_22108803_ChIP-Seq_LS180_Human1.20123866
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17527204
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.17371722
67P300_19829295_ChIP-Seq_ESCs_Human1.16449360
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16235425
69SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15522632
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15487122
71TCF4_22108803_ChIP-Seq_LS180_Human1.13895180
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13862589
73FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13653558
74AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13261674
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13232840
76* RACK7_27058665_Chip-Seq_MCF-7_Human1.13156916
77SMAD4_21799915_ChIP-Seq_A2780_Human1.12652310
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11071400
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09422893
80LXR_22292898_ChIP-Seq_THP-1_Human1.09221724
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08993419
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07775344
83AR_25329375_ChIP-Seq_VCAP_Human1.05807802
84* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05382793
85NANOG_19829295_ChIP-Seq_ESCs_Human1.05329645
86SOX2_19829295_ChIP-Seq_ESCs_Human1.05329645
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04708431
88TP63_23658742_ChIP-Seq_EP156T_Human1.04255039
89* STAT3_23295773_ChIP-Seq_U87_Human1.03938149
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03210889
91FUS_26573619_Chip-Seq_HEK293_Human1.03138294
92ER_23166858_ChIP-Seq_MCF-7_Human1.03023132
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02680863
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01379986
95* CBP_20019798_ChIP-Seq_JUKART_Human0.98578661
96* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98578661
97STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97584063
98SMAD3_21741376_ChIP-Seq_EPCs_Human0.97100112
99CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96996039
100GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96351683
101TCF4_23295773_ChIP-Seq_U87_Human0.96337786
102AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95118461
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95117382
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95069231
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94149196
106GATA3_24758297_ChIP-Seq_MCF-7_Human0.94080161
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93094397
108* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91542750
109* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91407301
110TCF4_18268006_ChIP-ChIP_LS174T_Human0.90965561
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90758355
112ZNF263_19887448_ChIP-Seq_K562_Human0.90684965
113TBX20_22080862_ChIP-Seq_HEART_Mouse0.90204170
114TBX20_22328084_ChIP-Seq_HEART_Mouse0.90204170
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.89643390
116ATF3_27146783_Chip-Seq_COLON_Human0.85289634
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84114599
118* FOXA1_25552417_ChIP-Seq_VCAP_Human0.82859028
119RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80588053
120RUNX1_27514584_Chip-Seq_MCF-7_Human0.79965496
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.79350655
122ZNF217_24962896_ChIP-Seq_MCF-7_Human0.76280066
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73911346
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71872809
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71819393
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.71625704
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.70517877
128P63_26484246_Chip-Seq_KERATINOCYTES_Human0.70126868
129IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.70099554
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69435125
131CREB1_26743006_Chip-Seq_LNCaP_Human0.68932448
132CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.68734245
133RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68656620
134EGR1_19032775_ChIP-ChIP_M12_Human0.67296627
135SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.67220764
136CDX2_22108803_ChIP-Seq_LS180_Human0.66894013
137SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.65950934
138IRF8_22096565_ChIP-ChIP_GC-B_Human0.64839953
139RARA_24833708_ChIP-Seq_LIVER_Mouse0.64196076
140SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63952415
141EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.63629517
142GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.63369183
143TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.62549960
144MYC_19915707_ChIP-ChIP_AK7_Human0.62391665
145AR_20517297_ChIP-Seq_VCAP_Human0.61713591
146TET1_21451524_ChIP-Seq_MESCs_Mouse0.61655964
147RAC3_21632823_ChIP-Seq_H3396_Human0.61125244
148NFIB_24661679_ChIP-Seq_LUNG_Mouse0.60690706
149SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.60584111
150EP300_21415370_ChIP-Seq_HL-1_Mouse0.58159447
151PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.58058757
152NRF2_20460467_ChIP-Seq_MEFs_Mouse0.57560766
153NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.57560766
154PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.57015147
155* TP63_22573176_ChIP-Seq_HFKS_Human0.55893279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.97093671
2MP0005365_abnormal_bile_salt4.91959018
3* MP0002139_abnormal_hepatobiliary_system4.90744530
4MP0005085_abnormal_gallbladder_physiolo4.63860155
5MP0003252_abnormal_bile_duct4.33990252
6MP0008875_abnormal_xenobiotic_pharmacok3.83999178
7MP0005332_abnormal_amino_acid3.79862546
8MP0003195_calcinosis3.76386869
9MP0004043_abnormal_pH_regulation3.75124082
10MP0004019_abnormal_vitamin_homeostasis3.64025265
11MP0003183_abnormal_peptide_metabolism3.49980205
12MP0002163_abnormal_gland_morphology3.34909010
13MP0005083_abnormal_biliary_tract3.25689563
14MP0009643_abnormal_urine_homeostasis3.05317555
15MP0001666_abnormal_nutrient_absorption2.93899686
16* MP0002138_abnormal_hepatobiliary_system2.92409125
17MP0008872_abnormal_physiological_respon2.47315960
18MP0001765_abnormal_ion_homeostasis2.42492194
19MP0005379_endocrine/exocrine_gland_phen2.36002580
20MP0003806_abnormal_nucleotide_metabolis2.28979615
21MP0005636_abnormal_mineral_homeostasis2.28058813
22MP0001756_abnormal_urination2.25516131
23MP0005220_abnormal_exocrine_pancreas2.17327897
24* MP0002928_abnormal_bile_duct2.11950050
25MP0003300_gastrointestinal_ulcer2.03422507
26MP0010329_abnormal_lipoprotein_level1.96037967
27MP0002136_abnormal_kidney_physiology1.94499922
28MP0002132_abnormal_respiratory_system1.83654646
29* MP0005084_abnormal_gallbladder_morpholo1.83067297
30MP0002254_reproductive_system_inflammat1.70357331
31MP0004264_abnormal_extraembryonic_tissu1.70060323
32MP0003191_abnormal_cellular_cholesterol1.69860722
33MP0005058_abnormal_lysosome_morphology1.65719990
34MP0002277_abnormal_respiratory_mucosa1.60216205
35MP0005319_abnormal_enzyme/_coenzyme1.56020992
36MP0010234_abnormal_vibrissa_follicle1.55480723
37MP0010678_abnormal_skin_adnexa1.55322625
38MP0000613_abnormal_salivary_gland1.49290258
39* MP0002118_abnormal_lipid_homeostasis1.46836359
40MP0003283_abnormal_digestive_organ1.44033737
41MP0003868_abnormal_feces_composition1.41612978
42MP0000538_abnormal_urinary_bladder1.41058201
43* MP0000609_abnormal_liver_physiology1.37866557
44MP0003186_abnormal_redox_activity1.37342173
45MP0005584_abnormal_enzyme/coenzyme_acti1.33691096
46MP0005645_abnormal_hypothalamus_physiol1.26180923
47MP0009840_abnormal_foam_cell1.25308223
48MP0001873_stomach_inflammation1.23652459
49MP0001944_abnormal_pancreas_morphology1.22830993
50MP0005377_hearing/vestibular/ear_phenot1.20067760
51MP0003878_abnormal_ear_physiology1.20067760
52MP0001958_emphysema1.19416573
53MP0008961_abnormal_basal_metabolism1.18698793
54MP0002876_abnormal_thyroid_physiology1.14598725
55MP0003950_abnormal_plasma_membrane1.12559676
56MP0000685_abnormal_immune_system1.11956188
57MP0001764_abnormal_homeostasis1.09823166
58MP0002168_other_aberrant_phenotype1.09522106
59MP0000003_abnormal_adipose_tissue1.09491578
60MP0000566_synostosis1.07021908
61MP0000383_abnormal_hair_follicle1.06370103
62MP0009780_abnormal_chondrocyte_physiolo1.01242242
63MP0003705_abnormal_hypodermis_morpholog0.97553678
64MP0005451_abnormal_body_composition0.97347177
65MP0005310_abnormal_salivary_gland0.96899112
66MP0004133_heterotaxia0.95109936
67MP0003943_abnormal_hepatobiliary_system0.94596028
68MP0005408_hypopigmentation0.94579741
69MP0002078_abnormal_glucose_homeostasis0.93048930
70* MP0000598_abnormal_liver_morphology0.93039921
71MP0002135_abnormal_kidney_morphology0.92505175
72MP0006036_abnormal_mitochondrial_physio0.89252952
73* MP0009642_abnormal_blood_homeostasis0.84820577
74MP0002166_altered_tumor_susceptibility0.84791317
75MP0005551_abnormal_eye_electrophysiolog0.83536487
76MP0003879_abnormal_hair_cell0.83138858
77MP0001986_abnormal_taste_sensitivity0.82662614
78MP0001485_abnormal_pinna_reflex0.82154525
79MP0002896_abnormal_bone_mineralization0.81886497
80MP0000639_abnormal_adrenal_gland0.80616722
81MP0005670_abnormal_white_adipose0.80434462
82MP0000516_abnormal_urinary_system0.80429365
83MP0005367_renal/urinary_system_phenotyp0.80429365
84MP0004272_abnormal_basement_membrane0.78863106
85MP0003938_abnormal_ear_development0.78634910
86MP0001348_abnormal_lacrimal_gland0.77696158
87MP0000372_irregular_coat_pigmentation0.77517250
88MP0005410_abnormal_fertilization0.77415022
89MP0002006_tumorigenesis0.76995548
90MP0000230_abnormal_systemic_arterial0.75340688
91MP0002796_impaired_skin_barrier0.70165379
92MP0003638_abnormal_response/metabolism_0.69240099
93MP0003959_abnormal_lean_body0.68143753
94MP0005395_other_phenotype0.66186101
95MP0000477_abnormal_intestine_morphology0.64751061
96MP0003953_abnormal_hormone_level0.64617648
97MP0005535_abnormal_body_temperature0.64341797
98MP0000678_abnormal_parathyroid_gland0.63369684
99MP0003724_increased_susceptibility_to0.62474168
100MP0002693_abnormal_pancreas_physiology0.62064643
101MP0001661_extended_life_span0.59931674
102MP0000631_abnormal_neuroendocrine_gland0.59418472
103MP0009764_decreased_sensitivity_to0.58828743
104MP0000462_abnormal_digestive_system0.58819004
105MP0008469_abnormal_protein_level0.58626606
106MP0002160_abnormal_reproductive_system0.58416654
107MP0004134_abnormal_chest_morphology0.57854226
108MP0008004_abnormal_stomach_pH0.57786622
109MP0009384_cardiac_valve_regurgitation0.57583762
110MP0005389_reproductive_system_phenotype0.57566575
111MP0003329_amyloid_beta_deposits0.56821388
112MP0009672_abnormal_birth_weight0.56632520
113MP0005666_abnormal_adipose_tissue0.56584988
114MP0010386_abnormal_urinary_bladder0.56307868
115MP0001849_ear_inflammation0.56238231
116MP0006054_spinal_hemorrhage0.54705416
117MP0003936_abnormal_reproductive_system0.54038759
118MP0004782_abnormal_surfactant_physiolog0.53863441
119MP0001790_abnormal_immune_system0.52765175
120MP0005387_immune_system_phenotype0.52765175
121MP0000534_abnormal_ureter_morphology0.52589911
122MP0010368_abnormal_lymphatic_system0.52479114
123MP0001984_abnormal_olfaction0.51483006
124MP0002098_abnormal_vibrissa_morphology0.50171315
125MP0000604_amyloidosis0.49279286
126MP0005167_abnormal_blood-brain_barrier0.48678795
127MP0001664_abnormal_digestion0.48652809
128MP0004885_abnormal_endolymph0.42532197
129MP0000537_abnormal_urethra_morphology0.41499719
130MP0005501_abnormal_skin_physiology0.40176509
131MP0000013_abnormal_adipose_tissue0.39247692
132MP0005375_adipose_tissue_phenotype0.38509367
133MP0005647_abnormal_sex_gland0.37597476
134MP0003942_abnormal_urinary_system0.37010424
135MP0009763_increased_sensitivity_to0.36810570
136MP0003045_fibrosis0.36720734
137MP0001270_distended_abdomen0.36676341
138MP0002089_abnormal_postnatal_growth/wei0.36052428
139MP0009765_abnormal_xenobiotic_induced0.35862791
140MP0003566_abnormal_cell_adhesion0.34638899
141MP0005376_homeostasis/metabolism_phenot0.34293219
142MP0002909_abnormal_adrenal_gland0.34188760

Predicted human phenotypes

RankGene SetZ-score
1* Gout (HP:0001997)5.52258010
2Hyperactive renin-angiotensin system (HP:0000841)5.09234973
3Increased circulating renin level (HP:0000848)5.03477840
4Hypokalemic alkalosis (HP:0001949)5.01808568
5Metabolic alkalosis (HP:0200114)4.89405931
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.87406262
7Abnormality of chloride homeostasis (HP:0011422)4.75222240
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.67838738
9Hyperglycinuria (HP:0003108)4.54194368
10Hypomagnesemia (HP:0002917)4.49808430
11Proximal tubulopathy (HP:0000114)4.43863693
12Polyuria (HP:0000103)4.40778395
13Ketoacidosis (HP:0001993)4.39662289
14Abnormal urine output (HP:0012590)4.33348911
15Abnormality of renal excretion (HP:0011036)4.33107458
16Ketosis (HP:0001946)4.21917285
17* Abnormality of purine metabolism (HP:0004352)4.11110400
18Alkalosis (HP:0001948)4.03830486
19Generalized aminoaciduria (HP:0002909)3.97829597
20Abnormality of serine family amino acid metabolism (HP:0010894)3.92372096
21Abnormality of glycine metabolism (HP:0010895)3.92372096
22Abnormality of magnesium homeostasis (HP:0004921)3.84235808
23Intrahepatic cholestasis (HP:0001406)3.82871330
24* Hyperuricemia (HP:0002149)3.78093724
25* Increased purine levels (HP:0004368)3.78093724
26Hypoglycemic coma (HP:0001325)3.76111668
27Pigmentary retinal degeneration (HP:0001146)3.74921971
28Abnormality of monocarboxylic acid metabolism (HP:0010996)3.54405387
29Abnormality of renin-angiotensin system (HP:0000847)3.53439344
30Renal salt wasting (HP:0000127)3.51731022
31Abnormal drinking behavior (HP:0030082)3.46158005
32Polydipsia (HP:0001959)3.46158005
33Enlarged kidneys (HP:0000105)3.43067364
34Tubular atrophy (HP:0000092)3.42375497
35Facial shape deformation (HP:0011334)3.40278106
36Potter facies (HP:0002009)3.40278106
37Hyperglycinemia (HP:0002154)3.38337157
38Hyperammonemia (HP:0001987)3.33365135
39Tetany (HP:0001281)3.31130429
40* Abnormality of nucleobase metabolism (HP:0010932)3.30798892
41Abnormality of fatty-acid metabolism (HP:0004359)3.26835868
42Abnormality of aspartate family amino acid metabolism (HP:0010899)3.24776453
43Xanthomatosis (HP:0000991)3.23400070
44Hyperaldosteronism (HP:0000859)3.21044705
45Congenital sensorineural hearing impairment (HP:0008527)3.20663184
46Hypothermia (HP:0002045)3.13290194
47Abnormality of sulfur amino acid metabolism (HP:0004339)3.07475405
48Abnormality of the nasal septum (HP:0000419)3.06810388
49* Glycosuria (HP:0003076)2.98361524
50* Abnormality of urine glucose concentration (HP:0011016)2.98361524
51* Abnormal pancreas size (HP:0012094)2.97841372
52Vascular calcification (HP:0004934)2.95691023
53Renal tubular acidosis (HP:0001947)2.91595008
54Pancreatic cysts (HP:0001737)2.89173099
55Deep venous thrombosis (HP:0002625)2.87566597
56Hypokalemia (HP:0002900)2.86706247
57Abnormality of vitamin B metabolism (HP:0004340)2.86554092
58Abnormality of proline metabolism (HP:0010907)2.83012828
59Hydroxyprolinuria (HP:0003080)2.83012828
60Delayed CNS myelination (HP:0002188)2.80569502
61Hyperphosphaturia (HP:0003109)2.78843816
62Decreased circulating renin level (HP:0003351)2.76744383
63Hypercalciuria (HP:0002150)2.76518281
64Tubulointerstitial fibrosis (HP:0005576)2.74667891
65Hypoglycemic seizures (HP:0002173)2.73086629
66Spontaneous abortion (HP:0005268)2.72357250
67Malnutrition (HP:0004395)2.72226111
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.70953354
69Dicarboxylic aciduria (HP:0003215)2.70953354
70Abnormality of vitamin metabolism (HP:0100508)2.69685527
71Cardiovascular calcification (HP:0011915)2.66471423
72Azoospermia (HP:0000027)2.63161363
73Metabolic acidosis (HP:0001942)2.60434570
74Fat malabsorption (HP:0002630)2.59808814
75Hypolipoproteinemia (HP:0010981)2.58752008
76Symptomatic seizures (HP:0011145)2.52469578
77Abnormality of the vitamin B12 metabolism (HP:0004341)2.52306743
78* Nephrolithiasis (HP:0000787)2.48904889
79Hypophosphatemia (HP:0002148)2.48546947
80Abnormal urine phosphate concentration (HP:0012599)2.48032821
81Rickets (HP:0002748)2.47956668
82Glomerulosclerosis (HP:0000096)2.46543316
83Cystic liver disease (HP:0006706)2.45037796
84Hyperinsulinemic hypoglycemia (HP:0000825)2.44978751
85Hepatocellular carcinoma (HP:0001402)2.44320132
86Hypoalphalipoproteinemia (HP:0003233)2.44244149
87Vacuolated lymphocytes (HP:0001922)2.42005811
88Abnormality of potassium homeostasis (HP:0011042)2.41550198
89Dehydration (HP:0001944)2.36362049
90Chronic hepatic failure (HP:0100626)2.32745968
91Irritability (HP:0000737)2.32104455
92Lethargy (HP:0001254)2.31933829
93Abnormality of the middle phalanges of the toes (HP:0010183)2.30954388
94Pendular nystagmus (HP:0012043)2.30619730
95Abnormal biliary tract morphology (HP:0012440)2.28565638
96Vomiting (HP:0002013)2.26603678
97Abnormal tarsal ossification (HP:0008369)2.25734390
98Stenosis of the external auditory canal (HP:0000402)2.25196894
99Sensorimotor neuropathy (HP:0007141)2.25150885
100Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.25094811
101Chorioretinal atrophy (HP:0000533)2.25003019
102Nephrocalcinosis (HP:0000121)2.24317534
103* Exocrine pancreatic insufficiency (HP:0001738)2.22606082
104Conical tooth (HP:0000698)2.20845270
105* Abnormal enzyme/coenzyme activity (HP:0012379)2.19749357
106Abnormality of the renal medulla (HP:0100957)2.17566033
107Abolished electroretinogram (ERG) (HP:0000550)2.16597202
108Hypobetalipoproteinemia (HP:0003563)2.16529331
109Widely patent fontanelles and sutures (HP:0004492)2.15906785
110Rectal prolapse (HP:0002035)2.15447080
111Delayed epiphyseal ossification (HP:0002663)2.14067196
112Methylmalonic acidemia (HP:0002912)2.10590489
113Severe visual impairment (HP:0001141)2.09682295
114Abnormality of the intrinsic pathway (HP:0010989)2.08897592
115Ileus (HP:0002595)2.08885337
116Abnormality of the common coagulation pathway (HP:0010990)2.07833337
117Esophageal varix (HP:0002040)2.06102174
118Abnormality of the renal cortex (HP:0011035)2.05547696
119Hyperglycemia (HP:0003074)2.04768624
120* Abnormality of alkaline phosphatase activity (HP:0004379)2.04756622
121Abnormality of serum amino acid levels (HP:0003112)2.04420800
122Focal segmental glomerulosclerosis (HP:0000097)2.02356028
123Conjugated hyperbilirubinemia (HP:0002908)2.01586974
124Prolonged partial thromboplastin time (HP:0003645)2.00527716
125Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.00498117
126Elevated alkaline phosphatase (HP:0003155)1.99478250
127Metaphyseal cupping (HP:0003021)1.99270952
128Confusion (HP:0001289)1.98149589
129Hyperkalemia (HP:0002153)1.97223921
130Hypophosphatemic rickets (HP:0004912)1.95179196
131Short hallux (HP:0010109)1.94214100
132Protuberant abdomen (HP:0001538)1.93949126
133Steatorrhea (HP:0002570)1.93863160
134* Late onset (HP:0003584)1.92720439
135Chronic diarrhea (HP:0002028)1.91619141
136Abnormality of endocrine pancreas physiology (HP:0012093)1.90492191
137True hermaphroditism (HP:0010459)1.90413364
138Tubulointerstitial abnormality (HP:0001969)1.88023219
139Abnormality of macular pigmentation (HP:0008002)1.87500482
140Decreased central vision (HP:0007663)1.85983166
141Stomach cancer (HP:0012126)1.82462495
142Osteomalacia (HP:0002749)1.82360966
143Methylmalonic aciduria (HP:0012120)1.82072384
144Renal cortical cysts (HP:0000803)1.81500787
145Amelogenesis imperfecta (HP:0000705)1.80556180
146Aplasia/Hypoplasia of the hallux (HP:0008362)1.79146188
147Insulin-resistant diabetes mellitus (HP:0000831)1.77257291
148Congenital stationary night blindness (HP:0007642)1.74066044

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK46.88880859
2WNK35.77155334
3BCKDK4.25941026
4OXSR14.23371909
5ERN13.16150607
6GRK12.86002432
7FRK2.74016977
8FGFR42.62814928
9MST1R2.48771825
10STK392.48622656
11INSRR2.35985297
12MAPK152.33065682
13STK38L2.27403264
14MAP3K91.83944760
15TAOK31.81859061
16TLK11.81187771
17ADRBK21.74508696
18PTK61.71671662
19STK241.60781642
20TRIB31.59901603
21EPHA21.57708842
22TNIK1.57510114
23ACVR1B1.55724557
24PTK21.52684512
25PDK31.44892716
26PDK41.44892716
27MST41.43705708
28SIK11.38619915
29DAPK21.35474510
30MET1.34516054
31MAP3K121.33790708
32EPHB11.33255127
33DYRK1B1.32793604
34PIK3CA1.25188549
35SGK4941.24462296
36SGK2231.24462296
37BMPR1B1.24333367
38LATS11.24137583
39MAP3K31.23821572
40IKBKB1.22438019
41MAPKAPK31.21381781
42ZAK1.19745989
43AKT31.11938493
44PRKCE1.11432053
45WNK11.10194231
46ERBB41.09241023
47MAP3K21.04634991
48LRRK21.04538863
49MAP2K21.03881426
50PAK41.02815141
51PRKCQ1.02807732
52RIPK11.00176313
53TRPM70.99986165
54NEK10.99769450
55BCR0.95445304
56SGK30.92384935
57PIK3CG0.91283344
58STK380.87361317
59GSK3A0.85317746
60FER0.85302376
61MAP3K100.82507230
62PASK0.81756388
63PDK20.80190624
64MAP3K70.79918913
65MAP4K20.79710019
66IRAK30.77348898
67MUSK0.75587473
68PRKCI0.73977770
69SGK20.72312615
70PNCK0.71116068
71LMTK20.68126367
72MAPK110.64440141
73IRAK10.62509772
74NUAK10.60706844
75EPHA30.59980804
76NME10.57700230
77GRK60.56798656
78PDGFRA0.54935700
79FGFR20.54897423
80PRKAA20.53823285
81PKN20.53375077
82PAK30.51742561
83CSF1R0.51612349
84FLT30.50367516
85MAP2K30.49482389
86NEK20.49168604
87PHKG20.48989706
88PHKG10.48989706
89PDPK10.48862614
90MAP2K60.47136544
91CDK90.47013142
92PRKAA10.46586057
93STK100.46353936
94PRKCZ0.45795355
95PRKD20.45709727
96MTOR0.45682289
97TGFBR20.45077035
98MAP3K140.45040150
99NLK0.44505851
100TESK10.44442114
101CAMK1G0.42097595
102PRKD30.41642853
103MAP2K10.41394720
104NEK90.41298503
105BRSK20.40464830
106MAP3K10.39987260
107MYLK0.39019419
108CSNK1A10.38939085
109PRKG20.38936057
110ROCK10.38339986
111DAPK30.38330571
112MAP4K10.38214686
113NTRK10.37536868
114MAPK70.35065255
115JAK20.34432109
116PRKCA0.34114412
117ABL20.34080689
118ERBB20.33655281
119MATK0.33186500
120TAOK20.32929723
121CSK0.32306946
122TBK10.32252927
123MAP3K110.31080436
124MELK0.30874310
125IRAK40.28807729
126PRKCH0.28722774
127JAK10.28519583
128IGF1R0.28317116
129MAP3K80.27776708
130DAPK10.27442941
131TIE10.27137251
132STK30.25757141
133PRKACG0.25405887
134CHUK0.25302369
135SGK10.25258139
136EIF2AK30.25147823
137BMX0.24937033
138PINK10.24180670
139VRK10.23995834
140FGFR10.22425900
141ZAP700.20949640
142TYK20.20483454
143EPHB20.19684798
144HIPK20.19391721
145FGFR30.18863014
146KSR20.18691323
147SCYL20.18542724
148PDK10.18532712
149PTK2B0.17371536

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.47946006
2Butanoate metabolism_Homo sapiens_hsa006502.99703104
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.91886249
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.90852803
5Tryptophan metabolism_Homo sapiens_hsa003802.71295787
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.69221111
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.65393694
8Sulfur metabolism_Homo sapiens_hsa009202.62868146
9Fatty acid degradation_Homo sapiens_hsa000712.52854940
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.49933971
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.49752859
12Propanoate metabolism_Homo sapiens_hsa006402.43936145
13Cyanoamino acid metabolism_Homo sapiens_hsa004602.38872168
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.35499412
15* Maturity onset diabetes of the young_Homo sapiens_hsa049502.33264640
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30874251
17Peroxisome_Homo sapiens_hsa041462.29208609
18Nitrogen metabolism_Homo sapiens_hsa009102.27025108
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.21423935
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.05344420
21Arginine biosynthesis_Homo sapiens_hsa002202.01100569
22Pyruvate metabolism_Homo sapiens_hsa006201.95973182
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90487278
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.89566387
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.87837541
26beta-Alanine metabolism_Homo sapiens_hsa004101.75126031
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72120590
28Selenocompound metabolism_Homo sapiens_hsa004501.71880723
29Fatty acid metabolism_Homo sapiens_hsa012121.71012762
30Vitamin digestion and absorption_Homo sapiens_hsa049771.69442613
31Bile secretion_Homo sapiens_hsa049761.65189322
32Histidine metabolism_Homo sapiens_hsa003401.63947491
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58857478
34PPAR signaling pathway_Homo sapiens_hsa033201.48591081
35Folate biosynthesis_Homo sapiens_hsa007901.40745775
36Carbon metabolism_Homo sapiens_hsa012001.36959725
37Starch and sucrose metabolism_Homo sapiens_hsa005001.36083516
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34621582
39Arginine and proline metabolism_Homo sapiens_hsa003301.30107607
40Phenylalanine metabolism_Homo sapiens_hsa003601.29726518
41Phototransduction_Homo sapiens_hsa047441.26660783
42Sphingolipid metabolism_Homo sapiens_hsa006001.26008747
43Ether lipid metabolism_Homo sapiens_hsa005651.24259306
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22933574
45Glutathione metabolism_Homo sapiens_hsa004801.22634702
46Chemical carcinogenesis_Homo sapiens_hsa052041.19973261
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18442993
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17728599
49Fat digestion and absorption_Homo sapiens_hsa049751.17220585
50Lysine degradation_Homo sapiens_hsa003101.17119714
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.16920676
52Complement and coagulation cascades_Homo sapiens_hsa046101.13148626
53Drug metabolism - other enzymes_Homo sapiens_hsa009831.09045959
54Protein digestion and absorption_Homo sapiens_hsa049741.07023669
55Glycerolipid metabolism_Homo sapiens_hsa005611.04978808
56Biosynthesis of amino acids_Homo sapiens_hsa012301.03819545
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.02461583
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00443257
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99517689
60Retinol metabolism_Homo sapiens_hsa008300.95362897
61Type I diabetes mellitus_Homo sapiens_hsa049400.89701351
62Mineral absorption_Homo sapiens_hsa049780.86555921
63Tyrosine metabolism_Homo sapiens_hsa003500.84032936
64Systemic lupus erythematosus_Homo sapiens_hsa053220.83977898
65Asthma_Homo sapiens_hsa053100.83081049
66Fatty acid elongation_Homo sapiens_hsa000620.82244637
67Steroid biosynthesis_Homo sapiens_hsa001000.81431084
68ABC transporters_Homo sapiens_hsa020100.77984110
69Other glycan degradation_Homo sapiens_hsa005110.77887625
70Allograft rejection_Homo sapiens_hsa053300.76090610
71Sulfur relay system_Homo sapiens_hsa041220.74749310
72Collecting duct acid secretion_Homo sapiens_hsa049660.68044114
73Fructose and mannose metabolism_Homo sapiens_hsa000510.65848936
74Autoimmune thyroid disease_Homo sapiens_hsa053200.65445947
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64499792
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64234517
77Fatty acid biosynthesis_Homo sapiens_hsa000610.62579968
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61931369
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57440229
80Graft-versus-host disease_Homo sapiens_hsa053320.56946908
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55136826
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53846227
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53518527
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.53391651
85Pentose phosphate pathway_Homo sapiens_hsa000300.52178771
86Renin-angiotensin system_Homo sapiens_hsa046140.51560032
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51409997
88Metabolic pathways_Homo sapiens_hsa011000.51362512
89Pancreatic secretion_Homo sapiens_hsa049720.50062863
90Caffeine metabolism_Homo sapiens_hsa002320.48870150
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44018916
92Dorso-ventral axis formation_Homo sapiens_hsa043200.42223872
93Thyroid hormone synthesis_Homo sapiens_hsa049180.41588501
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41331345
95Lysosome_Homo sapiens_hsa041420.40645146
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38990475
97Galactose metabolism_Homo sapiens_hsa000520.37619779
98African trypanosomiasis_Homo sapiens_hsa051430.35649908
99Protein export_Homo sapiens_hsa030600.34139821
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33676953
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32000716
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31606644
103Hepatitis C_Homo sapiens_hsa051600.31398164
104One carbon pool by folate_Homo sapiens_hsa006700.31177238
105Insulin resistance_Homo sapiens_hsa049310.30298738
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.29899104
107Insulin secretion_Homo sapiens_hsa049110.29581770
108Circadian rhythm_Homo sapiens_hsa047100.29537662
109Staphylococcus aureus infection_Homo sapiens_hsa051500.29221206
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.26331169
111Bladder cancer_Homo sapiens_hsa052190.24903169
112Vibrio cholerae infection_Homo sapiens_hsa051100.24082825
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17335619
114Vitamin B6 metabolism_Homo sapiens_hsa007500.14914062
115Arachidonic acid metabolism_Homo sapiens_hsa005900.13294686
116Glucagon signaling pathway_Homo sapiens_hsa049220.11933676
117Linoleic acid metabolism_Homo sapiens_hsa005910.07830059
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.06657467
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.05246780
120N-Glycan biosynthesis_Homo sapiens_hsa005100.04195371
121AMPK signaling pathway_Homo sapiens_hsa041520.03573394
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.01820636
123Regulation of autophagy_Homo sapiens_hsa041400.00186568
124Tight junction_Homo sapiens_hsa04530-0.0143718
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0115371

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