

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081) | 7.33420755 |
| 2 | regulation of guanylate cyclase activity (GO:0031282) | 7.15994535 |
| 3 | vitamin A metabolic process (GO:0006776) | 7.09071010 |
| 4 | fat-soluble vitamin biosynthetic process (GO:0042362) | 6.41286256 |
| 5 | virion attachment to host cell (GO:0019062) | 6.13300140 |
| 6 | adhesion of symbiont to host cell (GO:0044650) | 6.13300140 |
| 7 | flavonoid metabolic process (GO:0009812) | 6.06940618 |
| 8 | regulation of bile acid biosynthetic process (GO:0070857) | 5.88625793 |
| 9 | actin filament depolymerization (GO:0030042) | 5.72627902 |
| 10 | digestive system process (GO:0022600) | 5.70349708 |
| 11 | positive regulation of guanylate cyclase activity (GO:0031284) | 5.68210467 |
| 12 | cellular glucuronidation (GO:0052695) | 5.67754924 |
| 13 | glucuronate metabolic process (GO:0019585) | 5.59934392 |
| 14 | uronic acid metabolic process (GO:0006063) | 5.59934392 |
| 15 | drug catabolic process (GO:0042737) | 5.53405153 |
| 16 | purine ribonucleoside bisphosphate metabolic process (GO:0034035) | 5.39390294 |
| 17 | 3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427) | 5.39390294 |
| 18 | phospholipid efflux (GO:0033700) | 5.32093420 |
| 19 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 5.13503001 |
| 20 | fructose metabolic process (GO:0006000) | 5.10869445 |
| 21 | hormone catabolic process (GO:0042447) | 5.08189833 |
| 22 | plasma lipoprotein particle assembly (GO:0034377) | 5.06463145 |
| 23 | regulation of cholesterol esterification (GO:0010872) | 5.05554972 |
| 24 | peptide hormone processing (GO:0016486) | 5.00349972 |
| 25 | regulation of cellular extravasation (GO:0002691) | 4.97136685 |
| 26 | adhesion of symbiont to host (GO:0044406) | 4.93036316 |
| 27 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 4.90521230 |
| 28 | glucose 6-phosphate metabolic process (GO:0051156) | 4.86408835 |
| 29 | lipoprotein metabolic process (GO:0042157) | 4.85225251 |
| 30 | positive regulation of triglyceride lipase activity (GO:0061365) | 4.79624044 |
| 31 | positive regulation of lipoprotein lipase activity (GO:0051006) | 4.79624044 |
| 32 | protein-lipid complex assembly (GO:0065005) | 4.78843981 |
| 33 | digestion (GO:0007586) | 4.76692383 |
| 34 | peptide catabolic process (GO:0043171) | 4.74949458 |
| 35 | very-low-density lipoprotein particle assembly (GO:0034379) | 4.69683684 |
| 36 | regulation of triglyceride catabolic process (GO:0010896) | 4.67236529 |
| 37 | cholesterol efflux (GO:0033344) | 4.65955714 |
| 38 | modified amino acid transport (GO:0072337) | 4.61027395 |
| 39 | UDP-N-acetylglucosamine metabolic process (GO:0006047) | 4.58427788 |
| 40 | sulfate transmembrane transport (GO:1902358) | 4.56982957 |
| 41 | cellular response to hepatocyte growth factor stimulus (GO:0035729) | 4.52092248 |
| 42 | response to hepatocyte growth factor (GO:0035728) | 4.52092248 |
| 43 | regulation of cGMP biosynthetic process (GO:0030826) | 4.45991481 |
| 44 | receptor guanylyl cyclase signaling pathway (GO:0007168) | 4.40222191 |
| 45 | lipoprotein transport (GO:0042953) | 4.31531951 |
| 46 | drinking behavior (GO:0042756) | 4.25504063 |
| 47 | oligosaccharide catabolic process (GO:0009313) | 4.18727662 |
| 48 | cholesterol transport (GO:0030301) | 4.14575797 |
| 49 | sterol transport (GO:0015918) | 4.14575797 |
| 50 | transepithelial transport (GO:0070633) | 4.12855279 |
| 51 | bicarbonate transport (GO:0015701) | 4.09553694 |
| 52 | cholesterol homeostasis (GO:0042632) | 4.07168393 |
| 53 | glycolipid catabolic process (GO:0019377) | 4.06246442 |
| 54 | sterol homeostasis (GO:0055092) | 4.02397570 |
| 55 | nitrogen cycle metabolic process (GO:0071941) | 4.02344811 |
| 56 | sperm capacitation (GO:0048240) | 4.00552326 |
| 57 | glycosphingolipid catabolic process (GO:0046479) | 3.99612235 |
| 58 | regulation of vitamin metabolic process (GO:0030656) | 3.96683035 |
| 59 | renal system process involved in regulation of blood volume (GO:0001977) | 3.90196434 |
| 60 | antibacterial humoral response (GO:0019731) | 3.90043698 |
| 61 | alkaloid metabolic process (GO:0009820) | 3.87402054 |
| 62 | diacylglycerol metabolic process (GO:0046339) | 3.82792506 |
| 63 | fat-soluble vitamin metabolic process (GO:0006775) | 3.76183755 |
| 64 | bile acid metabolic process (GO:0008206) | 3.75821165 |
| 65 | antimicrobial humoral response (GO:0019730) | 3.73487253 |
| 66 | sulfation (GO:0051923) | 3.71812601 |
| 67 | cellular carbohydrate catabolic process (GO:0044275) | 3.71041362 |
| 68 | sulfate transport (GO:0008272) | 3.70444104 |
| 69 | negative regulation of cholesterol transport (GO:0032375) | 3.69953619 |
| 70 | negative regulation of sterol transport (GO:0032372) | 3.69953619 |
| 71 | regulation of cGMP metabolic process (GO:0030823) | 3.67634940 |
| 72 | positive regulation of glycoprotein biosynthetic process (GO:0010560) | 3.66716631 |
| 73 | sulfur compound transport (GO:0072348) | 3.60782334 |
| 74 | reverse cholesterol transport (GO:0043691) | 3.58407503 |
| 75 | arginine metabolic process (GO:0006525) | 3.56408121 |
| 76 | vitamin transmembrane transport (GO:0035461) | 3.56192380 |
| 77 | regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044) | 3.55603485 |
| 78 | endocrine process (GO:0050886) | 3.55603485 |
| 79 | regulation of systemic arterial blood pressure by hormone (GO:0001990) | 3.55603485 |
| 80 | glutamine family amino acid biosynthetic process (GO:0009084) | 3.53039309 |
| 81 | vitamin biosynthetic process (GO:0009110) | 3.52138986 |
| 82 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 3.51814128 |
| 83 | maintenance of gastrointestinal epithelium (GO:0030277) | 3.49631470 |
| 84 | polyol transport (GO:0015791) | 3.49405309 |
| 85 | NADH metabolic process (GO:0006734) | 3.49028820 |
| 86 | homocysteine metabolic process (GO:0050667) | 3.46547928 |
| 87 | positive regulation of fatty acid biosynthetic process (GO:0045723) | 3.46534935 |
| 88 | vitamin transport (GO:0051180) | 3.45592576 |
| 89 | mRNA modification (GO:0016556) | 3.42374631 |
| 90 | sphingomyelin metabolic process (GO:0006684) | 3.41654682 |
| 91 | negative regulation of digestive system process (GO:0060457) | 3.41002422 |
| 92 | positive regulation of cGMP biosynthetic process (GO:0030828) | 3.40678825 |
| 93 | cellular response to nitric oxide (GO:0071732) | 3.36526880 |
| 94 | nucleobase catabolic process (GO:0046113) | 3.36011263 |
| 95 | regulation of cholesterol homeostasis (GO:2000188) | 3.35740198 |
| 96 | glycerol metabolic process (GO:0006071) | 3.34800422 |
| 97 | cGMP biosynthetic process (GO:0006182) | 3.34700709 |
| 98 | thyroid hormone metabolic process (GO:0042403) | 3.34472407 |
| 99 | phospholipase C-activating dopamine receptor signaling pathway (GO:0060158) | 3.34461686 |
| 100 | purine nucleotide salvage (GO:0032261) | 3.34043780 |
| 101 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 3.30720908 |
| 102 | regulation of digestive system process (GO:0044058) | 3.29851203 |
| 103 | ceramide catabolic process (GO:0046514) | 3.28166252 |
| 104 | cytidine deamination (GO:0009972) | 3.27150606 |
| 105 | cytidine metabolic process (GO:0046087) | 3.27150606 |
| 106 | cytidine catabolic process (GO:0006216) | 3.27150606 |
| 107 | positive regulation of lipid catabolic process (GO:0050996) | 3.26330002 |
| 108 | glomerulus development (GO:0032835) | 3.26150920 |
| 109 | intestinal epithelial cell development (GO:0060576) | 3.24496864 |
| 110 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338) | 3.21479489 |
| 111 | regulation of actin nucleation (GO:0051125) | 3.21131230 |
| 112 | positive regulation of glycoprotein metabolic process (GO:1903020) | 3.20307180 |
| 113 | nucleoside diphosphate biosynthetic process (GO:0009133) | 3.19067589 |
| 114 | midgut development (GO:0007494) | 3.18803223 |
| 115 | drug transport (GO:0015893) | 3.18756854 |
| 116 | glycosylceramide metabolic process (GO:0006677) | 3.18353142 |
| 117 | positive regulation of pseudopodium assembly (GO:0031274) | 3.17522431 |
| 118 | urate metabolic process (GO:0046415) | 3.16401145 |
| 119 | O-glycan processing (GO:0016266) | 3.15819849 |
| 120 | cobalamin metabolic process (GO:0009235) | 3.15644023 |
| 121 | plasma lipoprotein particle organization (GO:0071827) | 3.14441897 |
| 122 | high-density lipoprotein particle remodeling (GO:0034375) | 3.13362746 |
| 123 | bile acid and bile salt transport (GO:0015721) | 3.12950329 |
| 124 | omega-hydroxylase P450 pathway (GO:0097267) | 3.11509019 |
| 125 | plasma lipoprotein particle remodeling (GO:0034369) | 3.11475939 |
| 126 | protein-lipid complex remodeling (GO:0034368) | 3.11475939 |
| 127 | macromolecular complex remodeling (GO:0034367) | 3.11475939 |
| 128 | protein-lipid complex subunit organization (GO:0071825) | 3.10793431 |
| 129 | epoxygenase P450 pathway (GO:0019373) | 3.09841655 |
| 130 | negative regulation of steroid metabolic process (GO:0045939) | 3.09280531 |
| 131 | phenylpropanoid metabolic process (GO:0009698) | 3.08802612 |
| 132 | transcytosis (GO:0045056) | 3.08311907 |
| 133 | urea cycle (GO:0000050) | 3.07747797 |
| 134 | urea metabolic process (GO:0019627) | 3.07747797 |
| 135 | vitamin D metabolic process (GO:0042359) | 3.06434882 |
| 136 | L-alpha-amino acid transmembrane transport (GO:1902475) | 3.06280733 |
| 137 | regulation of systemic arterial blood pressure (GO:0003073) | 3.04921587 |
| 138 | response to hydroperoxide (GO:0033194) | 3.03352244 |
| 139 | cellular anion homeostasis (GO:0030002) | 3.02723547 |
| 140 | glucan catabolic process (GO:0009251) | 3.01406363 |
| 141 | positive regulation of p38MAPK cascade (GO:1900745) | 2.97432652 |
| 142 | renal absorption (GO:0070293) | 2.95642841 |
| 143 | drug transmembrane transport (GO:0006855) | 2.95425983 |
| 144 | drug metabolic process (GO:0017144) | 2.94310889 |
| 145 | regulation of Golgi to plasma membrane protein transport (GO:0042996) | 2.91871362 |
| 146 | membrane repolarization during cardiac muscle cell action potential (GO:0086013) | 2.90924373 |
| 147 | exogenous drug catabolic process (GO:0042738) | 2.90135333 |
| 148 | phospholipid scrambling (GO:0017121) | 2.87624004 |
| 149 | intestinal absorption (GO:0050892) | 13.0514510 |
| 150 | intestinal cholesterol absorption (GO:0030299) | 12.2784516 |
| 151 | angiotensin maturation (GO:0002003) | 11.5445154 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 7.79482991 |
| 2 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 5.71776410 |
| 3 | * SOX2_27498859_Chip-Seq_STOMACH_Mouse | 3.67251603 |
| 4 | GATA4_25053715_ChIP-Seq_YYC3_Human | 3.13328678 |
| 5 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.97465517 |
| 6 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 2.84657303 |
| 7 | GATA6_25053715_ChIP-Seq_YYC3_Human | 2.62304234 |
| 8 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 2.60731955 |
| 9 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 2.60706194 |
| 10 | * SOX2_20726797_ChIP-Seq_SW620_Human | 2.59833314 |
| 11 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 2.58058094 |
| 12 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 2.55284057 |
| 13 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 2.39685750 |
| 14 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 2.18209252 |
| 15 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 2.16101375 |
| 16 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 2.04643575 |
| 17 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.04310561 |
| 18 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.96854841 |
| 19 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.92387723 |
| 20 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.90623399 |
| 21 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.83835140 |
| 22 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.83322271 |
| 23 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.82340705 |
| 24 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.73342770 |
| 25 | GATA1_22025678_ChIP-Seq_K562_Human | 1.72068749 |
| 26 | KLF5_25053715_ChIP-Seq_YYC3_Human | 1.64828147 |
| 27 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.60673399 |
| 28 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.60623891 |
| 29 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.56530800 |
| 30 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.50979642 |
| 31 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.49736045 |
| 32 | GATA2_19941826_ChIP-Seq_K562_Human | 1.45702922 |
| 33 | HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.40964538 |
| 34 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.40748997 |
| 35 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.40025763 |
| 36 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.38607292 |
| 37 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.33060146 |
| 38 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.32941353 |
| 39 | * RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.30479394 |
| 40 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.30336487 |
| 41 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.29122337 |
| 42 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.28023913 |
| 43 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.27278627 |
| 44 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.26607699 |
| 45 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.25015458 |
| 46 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.19915936 |
| 47 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.18229029 |
| 48 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 1.18139349 |
| 49 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.16761418 |
| 50 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.16426152 |
| 51 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.16259109 |
| 52 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.13039564 |
| 53 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.11877271 |
| 54 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.11170228 |
| 55 | VDR_22108803_ChIP-Seq_LS180_Human | 1.10344148 |
| 56 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.08800407 |
| 57 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.08794129 |
| 58 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.07246762 |
| 59 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.07216020 |
| 60 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.05775214 |
| 61 | TP53_16413492_ChIP-PET_HCT116_Human | 1.05375429 |
| 62 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.01885527 |
| 63 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.01414524 |
| 64 | TP63_23658742_ChIP-Seq_EP156T_Human | 0.99876998 |
| 65 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.99470418 |
| 66 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.99372215 |
| 67 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.99043651 |
| 68 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.98880002 |
| 69 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.98124603 |
| 70 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 0.97998260 |
| 71 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.97740744 |
| 72 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.97441316 |
| 73 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.96466540 |
| 74 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.96316722 |
| 75 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.95990082 |
| 76 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.95990082 |
| 77 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.95815361 |
| 78 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.94489422 |
| 79 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 0.94223470 |
| 80 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.92779155 |
| 81 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.91930949 |
| 82 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 0.91868887 |
| 83 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.91702284 |
| 84 | GATA1_19941826_ChIP-Seq_K562_Human | 0.91630156 |
| 85 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.90954670 |
| 86 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.90859730 |
| 87 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.90258645 |
| 88 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.90067112 |
| 89 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.89043597 |
| 90 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.88636084 |
| 91 | ATF3_27146783_Chip-Seq_COLON_Human | 0.87866695 |
| 92 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.87543517 |
| 93 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.87195407 |
| 94 | STAT1_17558387_ChIP-Seq_HELA_Human | 0.87133977 |
| 95 | CJUN_26792858_Chip-Seq_BT549_Human | 0.87059423 |
| 96 | DROSHA_22980978_ChIP-Seq_HELA_Human | 0.86895867 |
| 97 | * AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.84885767 |
| 98 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.84661349 |
| 99 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.82386412 |
| 100 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.82205317 |
| 101 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.81938839 |
| 102 | SA1_27219007_Chip-Seq_Bcells_Human | 0.81261093 |
| 103 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.80693401 |
| 104 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.80465325 |
| 105 | PCGF4_22325352_ChIP-Seq_293T-Rex_Human | 0.80426397 |
| 106 | CBP_21632823_ChIP-Seq_H3396_Human | 0.80294128 |
| 107 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.79999972 |
| 108 | AR_20517297_ChIP-Seq_VCAP_Human | 0.79794313 |
| 109 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.77807569 |
| 110 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.76873356 |
| 111 | NFYA_21822215_ChIP-Seq_K562_Human | 0.76314484 |
| 112 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.76208980 |
| 113 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.75942538 |
| 114 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.75780574 |
| 115 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.75336656 |
| 116 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 0.74863974 |
| 117 | * CDX2_22108803_ChIP-Seq_LS180_Human | 0.74690372 |
| 118 | ETV1_20927104_ChIP-Seq_GIST48_Human | 0.74683670 |
| 119 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.74557156 |
| 120 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 0.74214239 |
| 121 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.73993190 |
| 122 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.73719575 |
| 123 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.73613808 |
| 124 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.72310668 |
| 125 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.71350496 |
| 126 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.70031918 |
| 127 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.69920099 |
| 128 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.69385545 |
| 129 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.69363521 |
| 130 | RXR_22108803_ChIP-Seq_LS180_Human | 0.69282475 |
| 131 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.69186048 |
| 132 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.68815476 |
| 133 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.68542215 |
| 134 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.67612664 |
| 135 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.66816796 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005360_urolithiasis | 9.37584393 |
| 2 | MP0001666_abnormal_nutrient_absorption | 6.22442470 |
| 3 | MP0003183_abnormal_peptide_metabolism | 4.18909120 |
| 4 | MP0009840_abnormal_foam_cell | 3.74590954 |
| 5 | MP0002139_abnormal_hepatobiliary_system | 3.73521528 |
| 6 | MP0004264_abnormal_extraembryonic_tissu | 3.65583710 |
| 7 | MP0003252_abnormal_bile_duct | 3.38692967 |
| 8 | MP0008875_abnormal_xenobiotic_pharmacok | 3.33870053 |
| 9 | MP0010234_abnormal_vibrissa_follicle | 3.27050920 |
| 10 | MP0005085_abnormal_gallbladder_physiolo | 3.24331371 |
| 11 | MP0000462_abnormal_digestive_system | 3.23970822 |
| 12 | MP0003866_abnormal_defecation | 2.76453564 |
| 13 | MP0010329_abnormal_lipoprotein_level | 2.54242884 |
| 14 | MP0004147_increased_porphyrin_level | 2.24816075 |
| 15 | MP0004043_abnormal_pH_regulation | 2.23841315 |
| 16 | MP0004019_abnormal_vitamin_homeostasis | 2.20263342 |
| 17 | MP0003300_gastrointestinal_ulcer | 2.17906346 |
| 18 | MP0005365_abnormal_bile_salt | 2.06384807 |
| 19 | MP0002822_catalepsy | 2.05021503 |
| 20 | MP0005084_abnormal_gallbladder_morpholo | 1.93957400 |
| 21 | MP0000538_abnormal_urinary_bladder | 1.83574346 |
| 22 | MP0001664_abnormal_digestion | 1.82282661 |
| 23 | MP0005381_digestive/alimentary_phenotyp | 1.73686058 |
| 24 | MP0009697_abnormal_copulation | 1.72440786 |
| 25 | MP0001663_abnormal_digestive_system | 1.71555284 |
| 26 | MP0002254_reproductive_system_inflammat | 1.69171590 |
| 27 | MP0001873_stomach_inflammation | 1.64476472 |
| 28 | MP0005670_abnormal_white_adipose | 1.62828030 |
| 29 | MP0010155_abnormal_intestine_physiology | 1.58651299 |
| 30 | MP0002089_abnormal_postnatal_growth/wei | 1.51940526 |
| 31 | MP0009379_abnormal_foot_pigmentation | 1.51340573 |
| 32 | MP0000537_abnormal_urethra_morphology | 1.50774403 |
| 33 | MP0003878_abnormal_ear_physiology | 1.49663167 |
| 34 | MP0005377_hearing/vestibular/ear_phenot | 1.49663167 |
| 35 | MP0000477_abnormal_intestine_morphology | 1.49172083 |
| 36 | MP0009780_abnormal_chondrocyte_physiolo | 1.42300985 |
| 37 | MP0010352_gastrointestinal_tract_polyps | 1.39473385 |
| 38 | MP0006054_spinal_hemorrhage | 1.37707040 |
| 39 | MP0000490_abnormal_crypts_of | 1.35944929 |
| 40 | MP0001501_abnormal_sleep_pattern | 1.18554068 |
| 41 | MP0009643_abnormal_urine_homeostasis | 1.14876792 |
| 42 | MP0003191_abnormal_cellular_cholesterol | 1.14507107 |
| 43 | MP0005332_abnormal_amino_acid | 1.13914147 |
| 44 | MP0004782_abnormal_surfactant_physiolog | 1.13479285 |
| 45 | * MP0005448_abnormal_energy_balance | 1.10386888 |
| 46 | MP0002796_impaired_skin_barrier | 1.07456572 |
| 47 | MP0002138_abnormal_hepatobiliary_system | 1.06454206 |
| 48 | MP0003879_abnormal_hair_cell | 1.05935033 |
| 49 | MP0002876_abnormal_thyroid_physiology | 1.04315857 |
| 50 | MP0002118_abnormal_lipid_homeostasis | 1.00962383 |
| 51 | MP0005535_abnormal_body_temperature | 0.98349584 |
| 52 | MP0003806_abnormal_nucleotide_metabolis | 0.95375213 |
| 53 | MP0003705_abnormal_hypodermis_morpholog | 0.95137207 |
| 54 | MP0005451_abnormal_body_composition | 0.94537728 |
| 55 | MP0002277_abnormal_respiratory_mucosa | 0.94214069 |
| 56 | MP0008872_abnormal_physiological_respon | 0.94157956 |
| 57 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.91989813 |
| 58 | MP0000609_abnormal_liver_physiology | 0.90903059 |
| 59 | MP0003283_abnormal_digestive_organ | 0.90550941 |
| 60 | MP0000467_abnormal_esophagus_morphology | 0.89867768 |
| 61 | MP0002971_abnormal_brown_adipose | 0.89845401 |
| 62 | MP0001849_ear_inflammation | 0.89665497 |
| 63 | MP0002396_abnormal_hematopoietic_system | 0.89348311 |
| 64 | MP0004270_analgesia | 0.89002817 |
| 65 | MP0000678_abnormal_parathyroid_gland | 0.88482684 |
| 66 | MP0002098_abnormal_vibrissa_morphology | 0.86514004 |
| 67 | MP0003718_maternal_effect | 0.85381374 |
| 68 | MP0004947_skin_inflammation | 0.84515159 |
| 69 | MP0004858_abnormal_nervous_system | 0.82750176 |
| 70 | MP0009053_abnormal_anal_canal | 0.81129854 |
| 71 | MP0001765_abnormal_ion_homeostasis | 0.80838537 |
| 72 | MP0005266_abnormal_metabolism | 0.79970539 |
| 73 | MP0000230_abnormal_systemic_arterial | 0.79909287 |
| 74 | MP0010678_abnormal_skin_adnexa | 0.78732806 |
| 75 | MP0001845_abnormal_inflammatory_respons | 0.76528184 |
| 76 | MP0005367_renal/urinary_system_phenotyp | 0.76459740 |
| 77 | MP0000516_abnormal_urinary_system | 0.76459740 |
| 78 | MP0001764_abnormal_homeostasis | 0.75312897 |
| 79 | MP0000566_synostosis | 0.74239150 |
| 80 | MP0008469_abnormal_protein_level | 0.73023475 |
| 81 | MP0005408_hypopigmentation | 0.71208576 |
| 82 | MP0005636_abnormal_mineral_homeostasis | 0.70671798 |
| 83 | MP0009785_altered_susceptibility_to | 0.70632751 |
| 84 | MP0000613_abnormal_salivary_gland | 0.69896526 |
| 85 | MP0009765_abnormal_xenobiotic_induced | 0.66829017 |
| 86 | MP0003453_abnormal_keratinocyte_physiol | 0.65299990 |
| 87 | MP0002009_preneoplasia | 0.65076767 |
| 88 | MP0002136_abnormal_kidney_physiology | 0.64908658 |
| 89 | MP0005319_abnormal_enzyme/_coenzyme | 0.64500045 |
| 90 | MP0009384_cardiac_valve_regurgitation | 0.62659728 |
| 91 | MP0005501_abnormal_skin_physiology | 0.59623669 |
| 92 | MP0000470_abnormal_stomach_morphology | 0.59214323 |
| 93 | MP0005167_abnormal_blood-brain_barrier | 0.58986979 |
| 94 | MP0002166_altered_tumor_susceptibility | 0.56478097 |
| 95 | MP0003953_abnormal_hormone_level | 0.55920155 |
| 96 | MP0001485_abnormal_pinna_reflex | 0.55380917 |
| 97 | MP0006082_CNS_inflammation | 0.55190878 |
| 98 | MP0000249_abnormal_blood_vessel | 0.55000593 |
| 99 | MP0005310_abnormal_salivary_gland | 0.54828946 |
| 100 | MP0005666_abnormal_adipose_tissue | 0.53719366 |
| 101 | MP0009642_abnormal_blood_homeostasis | 0.53255863 |
| 102 | MP0000465_gastrointestinal_hemorrhage | 0.53240003 |
| 103 | MP0002163_abnormal_gland_morphology | 0.52520411 |
| 104 | MP0008004_abnormal_stomach_pH | 0.51946581 |
| 105 | MP0005376_homeostasis/metabolism_phenot | 0.50653140 |
| 106 | MP0002078_abnormal_glucose_homeostasis | 0.49042077 |
| 107 | MP0001216_abnormal_epidermal_layer | 0.48330593 |
| 108 | MP0003941_abnormal_skin_development | 0.48142698 |
| 109 | MP0003638_abnormal_response/metabolism_ | 0.47925990 |
| 110 | MP0001191_abnormal_skin_condition | 0.47253467 |
| 111 | MP0009764_decreased_sensitivity_to | 0.47244763 |
| 112 | MP0009115_abnormal_fat_cell | 0.47116396 |
| 113 | MP0005409_darkened_coat_color | 0.47091961 |
| 114 | MP0005166_decreased_susceptibility_to | 0.46832548 |
| 115 | MP0005334_abnormal_fat_pad | 0.46452540 |
| 116 | MP0005025_abnormal_response_to | 0.43451785 |
| 117 | MP0009333_abnormal_splenocyte_physiolog | 0.43405608 |
| 118 | MP0001756_abnormal_urination | 0.42934666 |
| 119 | MP0003868_abnormal_feces_composition | 0.42658388 |
| 120 | MP0005165_increased_susceptibility_to | 0.41842595 |
| 121 | MP0000427_abnormal_hair_cycle | 0.41757090 |
| 122 | MP0003119_abnormal_digestive_system | 0.40602453 |
| 123 | MP0001790_abnormal_immune_system | 0.40582158 |
| 124 | MP0005387_immune_system_phenotype | 0.40582158 |
| 125 | MP0002896_abnormal_bone_mineralization | 0.40459056 |
| 126 | MP0006138_congestive_heart_failure | 0.40188673 |
| 127 | MP0001188_hyperpigmentation | 0.40084560 |
| 128 | MP0005174_abnormal_tail_pigmentation | 0.39748000 |
| 129 | MP0001881_abnormal_mammary_gland | 0.39600784 |
| 130 | MP0000681_abnormal_thyroid_gland | 0.39218326 |
| 131 | MP0000604_amyloidosis | 0.39018687 |
| 132 | MP0001835_abnormal_antigen_presentation | 0.38510503 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ileus (HP:0002595) | 9.38802622 |
| 2 | Acanthocytosis (HP:0001927) | 7.52349337 |
| 3 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 7.06679534 |
| 4 | Hypobetalipoproteinemia (HP:0003563) | 7.01032029 |
| 5 | Conjugated hyperbilirubinemia (HP:0002908) | 5.88791100 |
| 6 | Malnutrition (HP:0004395) | 5.63346824 |
| 7 | Hydroxyprolinuria (HP:0003080) | 5.51116920 |
| 8 | Abnormality of proline metabolism (HP:0010907) | 5.51116920 |
| 9 | Autoimmune thrombocytopenia (HP:0001973) | 5.28342574 |
| 10 | Right ventricular cardiomyopathy (HP:0011663) | 4.84073079 |
| 11 | Chronic diarrhea (HP:0002028) | 4.51357023 |
| 12 | Autoimmune hemolytic anemia (HP:0001890) | 4.38809745 |
| 13 | Fat malabsorption (HP:0002630) | 4.38323034 |
| 14 | Poikilocytosis (HP:0004447) | 4.36644144 |
| 15 | Pigmentary retinal degeneration (HP:0001146) | 4.33616624 |
| 16 | Widely patent fontanelles and sutures (HP:0004492) | 4.13304044 |
| 17 | Cupped ribs (HP:0000887) | 4.05283614 |
| 18 | Glycosuria (HP:0003076) | 3.98994413 |
| 19 | Abnormality of urine glucose concentration (HP:0011016) | 3.98994413 |
| 20 | Hypolipoproteinemia (HP:0010981) | 3.83981048 |
| 21 | Facial shape deformation (HP:0011334) | 3.74057543 |
| 22 | Potter facies (HP:0002009) | 3.74057543 |
| 23 | Abdominal distention (HP:0003270) | 3.72900046 |
| 24 | Systemic lupus erythematosus (HP:0002725) | 3.50156608 |
| 25 | Metabolic alkalosis (HP:0200114) | 3.38424681 |
| 26 | Abnormal glucose tolerance (HP:0001952) | 3.33524992 |
| 27 | Dehydration (HP:0001944) | 3.33412431 |
| 28 | Increased IgE level (HP:0003212) | 3.32695122 |
| 29 | Gastrointestinal dysmotility (HP:0002579) | 3.32641648 |
| 30 | Decreased circulating renin level (HP:0003351) | 3.30265056 |
| 31 | Hyperglycinuria (HP:0003108) | 3.24530010 |
| 32 | Steatorrhea (HP:0002570) | 3.23800676 |
| 33 | Alkalosis (HP:0001948) | 3.19078217 |
| 34 | Hyperuricemia (HP:0002149) | 3.01482646 |
| 35 | Increased purine levels (HP:0004368) | 3.01482646 |
| 36 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 3.00158130 |
| 37 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 2.98371648 |
| 38 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 2.89447707 |
| 39 | Mesangial abnormality (HP:0001966) | 2.87164389 |
| 40 | Wide cranial sutures (HP:0010537) | 2.86568004 |
| 41 | Rectal prolapse (HP:0002035) | 2.86044473 |
| 42 | Abnormality of chloride homeostasis (HP:0011422) | 2.85921310 |
| 43 | Abnormality of vitamin B metabolism (HP:0004340) | 2.83481235 |
| 44 | Hyperammonemia (HP:0001987) | 2.82376759 |
| 45 | Posterior subcapsular cataract (HP:0007787) | 2.78734139 |
| 46 | Abnormal biliary tract morphology (HP:0012440) | 2.78515858 |
| 47 | Xanthomatosis (HP:0000991) | 2.78088665 |
| 48 | Abnormality of renin-angiotensin system (HP:0000847) | 2.76404990 |
| 49 | Abnormality of purine metabolism (HP:0004352) | 2.75221966 |
| 50 | Epidermoid cyst (HP:0200040) | 2.69530450 |
| 51 | Intrahepatic cholestasis (HP:0001406) | 2.68446431 |
| 52 | Nephrolithiasis (HP:0000787) | 2.67310935 |
| 53 | Focal segmental glomerulosclerosis (HP:0000097) | 2.63952419 |
| 54 | Hypercholesterolemia (HP:0003124) | 2.62395383 |
| 55 | Congenital sensorineural hearing impairment (HP:0008527) | 2.61138572 |
| 56 | Hyperphosphaturia (HP:0003109) | 2.60182309 |
| 57 | Abnormality of the gastric mucosa (HP:0004295) | 2.59130180 |
| 58 | Abnormality of B cell number (HP:0010975) | 2.57369150 |
| 59 | B lymphocytopenia (HP:0010976) | 2.57369150 |
| 60 | Villous atrophy (HP:0011473) | 2.52797355 |
| 61 | Abnormality of small intestinal villus morphology (HP:0011472) | 2.52797355 |
| 62 | Hypoproteinemia (HP:0003075) | 2.52442681 |
| 63 | Severe combined immunodeficiency (HP:0004430) | 2.51901279 |
| 64 | Symptomatic seizures (HP:0011145) | 2.51770188 |
| 65 | Abnormality of the costochondral junction (HP:0000919) | 2.48162771 |
| 66 | Progressive sensorineural hearing impairment (HP:0000408) | 2.47762160 |
| 67 | Abnormality of vitamin metabolism (HP:0100508) | 2.47173558 |
| 68 | Gout (HP:0001997) | 2.47007083 |
| 69 | Increased mean platelet volume (HP:0011877) | 2.46769092 |
| 70 | Reticulocytosis (HP:0001923) | 2.39880418 |
| 71 | Renal tubular acidosis (HP:0001947) | 2.38880073 |
| 72 | Metabolic acidosis (HP:0001942) | 2.37762258 |
| 73 | Abnormal urine phosphate concentration (HP:0012599) | 2.37065622 |
| 74 | Palpitations (HP:0001962) | 2.35891042 |
| 75 | Delayed epiphyseal ossification (HP:0002663) | 2.34130804 |
| 76 | Proximal tubulopathy (HP:0000114) | 2.31992257 |
| 77 | Hyperactive renin-angiotensin system (HP:0000841) | 2.30977688 |
| 78 | Hypotension (HP:0002615) | 2.26968439 |
| 79 | Subcapsular cataract (HP:0000523) | 2.25080519 |
| 80 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.25029654 |
| 81 | Abnormal platelet volume (HP:0011876) | 2.24173601 |
| 82 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.23927971 |
| 83 | Thyroiditis (HP:0100646) | 2.22759354 |
| 84 | Fragile skin (HP:0001030) | 2.22700656 |
| 85 | Hemorrhage of the eye (HP:0011885) | 2.21887665 |
| 86 | Syncope (HP:0001279) | 2.18301948 |
| 87 | Confusion (HP:0001289) | 2.17156685 |
| 88 | Combined immunodeficiency (HP:0005387) | 2.16746544 |
| 89 | Thin bony cortex (HP:0002753) | 2.15416309 |
| 90 | Osteomalacia (HP:0002749) | 2.14278287 |
| 91 | Protuberant abdomen (HP:0001538) | 2.13177987 |
| 92 | Hypoglycemic coma (HP:0001325) | 2.13053914 |
| 93 | Abnormality of nucleobase metabolism (HP:0010932) | 2.12724832 |
| 94 | Hyperparathyroidism (HP:0000843) | 2.08583984 |
| 95 | Late onset (HP:0003584) | 2.07896137 |
| 96 | Nausea (HP:0002018) | 2.06927339 |
| 97 | Woolly hair (HP:0002224) | 2.06633546 |
| 98 | Polycythemia (HP:0001901) | 2.06423517 |
| 99 | Generalized aminoaciduria (HP:0002909) | 2.06211651 |
| 100 | Renal tubular dysfunction (HP:0000124) | 2.05449185 |
| 101 | Cerebral palsy (HP:0100021) | 2.05046750 |
| 102 | Hypophosphatemia (HP:0002148) | 2.04584334 |
| 103 | Male infertility (HP:0003251) | 2.04076032 |
| 104 | Complement deficiency (HP:0004431) | 2.03860385 |
| 105 | Glomerulosclerosis (HP:0000096) | 2.03675072 |
| 106 | Eczematoid dermatitis (HP:0000976) | 2.03102732 |
| 107 | Abnormality of glycine metabolism (HP:0010895) | 2.02097259 |
| 108 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.02097259 |
| 109 | Progressive hearing impairment (HP:0001730) | 2.01399005 |
| 110 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.00689504 |
| 111 | Dicarboxylic aciduria (HP:0003215) | 2.00689504 |
| 112 | Glomerulonephritis (HP:0000099) | 1.97533186 |
| 113 | Pancreatitis (HP:0001733) | 1.97373926 |
| 114 | Milia (HP:0001056) | 1.96922630 |
| 115 | Hyperbilirubinemia (HP:0002904) | 1.96208601 |
| 116 | Abnormality of magnesium homeostasis (HP:0004921) | 1.96077542 |
| 117 | Cheilitis (HP:0100825) | 1.95556750 |
| 118 | Hyperphosphatemia (HP:0002905) | 1.94981846 |
| 119 | Exocrine pancreatic insufficiency (HP:0001738) | 1.92773266 |
| 120 | Flat acetabular roof (HP:0003180) | 1.92384739 |
| 121 | Enlarged epiphyses (HP:0010580) | 1.89806921 |
| 122 | Abnormality of complement system (HP:0005339) | 1.88315917 |
| 123 | Pustule (HP:0200039) | 1.86625282 |
| 124 | Ventricular fibrillation (HP:0001663) | 1.85692485 |
| 125 | Abnormal tarsal ossification (HP:0008369) | 1.84839127 |
| 126 | Irritability (HP:0000737) | 1.84548829 |
| 127 | Metaphyseal irregularity (HP:0003025) | 1.83337160 |
| 128 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 1.82744136 |
| 129 | Pili torti (HP:0003777) | 1.80230558 |
| 130 | Hyperaldosteronism (HP:0000859) | 1.77761789 |
| 131 | Nephritis (HP:0000123) | 1.77605528 |
| 132 | Hypokalemia (HP:0002900) | 1.73402908 |
| 133 | Hypophosphatemic rickets (HP:0004912) | 1.72999361 |
| 134 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 1.72307154 |
| 135 | Biliary tract neoplasm (HP:0100574) | 1.72223678 |
| 136 | Multiple lipomas (HP:0001012) | 1.71261943 |
| 137 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.70350640 |
| 138 | Megaloblastic anemia (HP:0001889) | 1.70078806 |
| 139 | Hypoalbuminemia (HP:0003073) | 1.70001829 |
| 140 | Abnormal albumin level (HP:0012116) | 1.70001829 |
| 141 | Reduced antithrombin III activity (HP:0001976) | 1.68186534 |
| 142 | Hypoplasia of dental enamel (HP:0006297) | 1.65807800 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ACVR1B | 8.16245745 |
| 2 | FRK | 7.71073723 |
| 3 | LMTK2 | 6.95658998 |
| 4 | MST4 | 5.00013320 |
| 5 | PRKG2 | 3.78515149 |
| 6 | MST1R | 3.66385529 |
| 7 | NME1 | 3.12689104 |
| 8 | AKT3 | 3.05525821 |
| 9 | STK24 | 2.96357764 |
| 10 | GRK6 | 2.74605258 |
| 11 | NUAK1 | 2.48490434 |
| 12 | RIPK1 | 2.47988696 |
| 13 | EPHA2 | 2.29218345 |
| 14 | MAP3K10 | 2.03548597 |
| 15 | MAP3K2 | 2.02000219 |
| 16 | MAP3K12 | 2.00670014 |
| 17 | PTK6 | 1.87533284 |
| 18 | MAP2K2 | 1.75863849 |
| 19 | ERN1 | 1.49002266 |
| 20 | EPHA3 | 1.44751671 |
| 21 | EPHB2 | 1.31809582 |
| 22 | BMPR2 | 1.27833118 |
| 23 | LATS1 | 1.23753380 |
| 24 | INSRR | 1.20683194 |
| 25 | MET | 1.19367225 |
| 26 | TAOK3 | 1.18685029 |
| 27 | STK38L | 1.18115967 |
| 28 | FGFR3 | 1.06438367 |
| 29 | EPHA4 | 1.03503463 |
| 30 | TESK1 | 1.03108572 |
| 31 | PRKCI | 0.93437029 |
| 32 | MAP2K6 | 0.89956876 |
| 33 | STK10 | 0.88741227 |
| 34 | EPHB1 | 0.86301247 |
| 35 | PTK2 | 0.85047839 |
| 36 | IRAK3 | 0.83925690 |
| 37 | PIK3CA | 0.82600815 |
| 38 | MAP3K7 | 0.81241162 |
| 39 | ERBB2 | 0.80863196 |
| 40 | PRKAA2 | 0.79904839 |
| 41 | DYRK1B | 0.79200547 |
| 42 | TNIK | 0.78809111 |
| 43 | FER | 0.76456841 |
| 44 | TTK | 0.74423498 |
| 45 | MAPK15 | 0.73849563 |
| 46 | MYLK | 0.69307975 |
| 47 | TAOK1 | 0.67140988 |
| 48 | MATK | 0.66534484 |
| 49 | BMX | 0.66297082 |
| 50 | PIM1 | 0.64928154 |
| 51 | PBK | 0.64876644 |
| 52 | YES1 | 0.62663077 |
| 53 | DDR2 | 0.62274870 |
| 54 | STK39 | 0.61350508 |
| 55 | GRK1 | 0.58804652 |
| 56 | RIPK4 | 0.58757959 |
| 57 | MAP4K1 | 0.57871183 |
| 58 | SCYL2 | 0.57779305 |
| 59 | MAP3K8 | 0.57079377 |
| 60 | TESK2 | 0.56579253 |
| 61 | IKBKE | 0.53147988 |
| 62 | IRAK1 | 0.52493074 |
| 63 | PRKAA1 | 0.51020519 |
| 64 | PRKCZ | 0.50434977 |
| 65 | MAPK11 | 0.48124299 |
| 66 | PAK3 | 0.48120430 |
| 67 | ERBB3 | 0.47711150 |
| 68 | RET | 0.46380925 |
| 69 | MAP3K14 | 0.43839026 |
| 70 | ABL2 | 0.43407488 |
| 71 | MAP3K11 | 0.42473615 |
| 72 | OXSR1 | 0.42241961 |
| 73 | NEK6 | 0.41975886 |
| 74 | CSF1R | 0.41958781 |
| 75 | NLK | 0.39556254 |
| 76 | PDK2 | 0.39061836 |
| 77 | MAP3K1 | 0.38952215 |
| 78 | TBK1 | 0.38659887 |
| 79 | CAMK2G | 0.38589982 |
| 80 | PAK4 | 0.38531101 |
| 81 | MELK | 0.38324038 |
| 82 | JAK1 | 0.38221645 |
| 83 | CSK | 0.38039440 |
| 84 | SIK3 | 0.37420415 |
| 85 | MAP2K1 | 0.36837436 |
| 86 | PRKCA | 0.34448827 |
| 87 | PDGFRA | 0.32626857 |
| 88 | CSNK1A1 | 0.31889065 |
| 89 | ERBB4 | 0.31099808 |
| 90 | TYK2 | 0.29487636 |
| 91 | MAP3K3 | 0.29412543 |
| 92 | STK3 | 0.27919721 |
| 93 | CASK | 0.27006858 |
| 94 | PDPK1 | 0.25252519 |
| 95 | PIK3CG | 0.24918915 |
| 96 | MAP3K5 | 0.24679710 |
| 97 | WNK4 | 0.24589646 |
| 98 | CDK12 | 0.23890479 |
| 99 | CDK6 | 0.23831024 |
| 100 | HIPK2 | 0.23293039 |
| 101 | SRC | 0.23248288 |
| 102 | PRKCD | 0.22660185 |
| 103 | TEC | 0.22461385 |
| 104 | PRKACG | 0.21735937 |
| 105 | PDK3 | 0.21459154 |
| 106 | PDK4 | 0.21459154 |
| 107 | MAP3K6 | 0.21171029 |
| 108 | PRKACA | 0.20762186 |
| 109 | AKT2 | 0.20595316 |
| 110 | CHUK | 0.18771637 |
| 111 | IGF1R | 0.18278582 |
| 112 | ITK | 0.18241211 |
| 113 | CDC42BPA | 0.17696332 |
| 114 | GSK3A | 0.17653495 |
| 115 | ROCK1 | 0.17421604 |
| 116 | CAMK2D | 0.17049972 |
| 117 | CDK19 | 0.16790205 |
| 118 | CAMK2A | 0.16768519 |
| 119 | PRKCQ | 0.16704727 |
| 120 | SYK | 0.16440074 |
| 121 | MAPKAPK3 | 0.16337189 |
| 122 | KSR2 | 0.15451758 |
| 123 | PDK1 | 0.14621502 |
| 124 | AURKB | 0.13459622 |
| 125 | MAPKAPK2 | 0.12855206 |
| 126 | BCR | 0.11961782 |
| 127 | JAK2 | 0.11572202 |
| 128 | FGFR4 | 0.11411516 |
| 129 | CDK5 | 0.11125849 |
| 130 | ICK | 0.10856819 |
| 131 | PRKCE | 0.10536207 |
| 132 | FYN | 0.10355124 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Fat digestion and absorption_Homo sapiens_hsa04975 | 5.80049065 |
| 2 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 5.07816918 |
| 3 | Renin-angiotensin system_Homo sapiens_hsa04614 | 4.47537033 |
| 4 | Mineral absorption_Homo sapiens_hsa04978 | 4.19375243 |
| 5 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 3.86215093 |
| 6 | Galactose metabolism_Homo sapiens_hsa00052 | 3.35529501 |
| 7 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 3.25591104 |
| 8 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.06222567 |
| 9 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 3.03181696 |
| 10 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.65809250 |
| 11 | Protein digestion and absorption_Homo sapiens_hsa04974 | 2.31947767 |
| 12 | Folate biosynthesis_Homo sapiens_hsa00790 | 2.25094301 |
| 13 | Bile secretion_Homo sapiens_hsa04976 | 2.12513994 |
| 14 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.84001856 |
| 15 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.79070367 |
| 16 | * Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.73279988 |
| 17 | Histidine metabolism_Homo sapiens_hsa00340 | 1.68802458 |
| 18 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.64288807 |
| 19 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.62240165 |
| 20 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.47488441 |
| 21 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.34024021 |
| 22 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.32034565 |
| 23 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.28557964 |
| 24 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.21564748 |
| 25 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.21372336 |
| 26 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.20127474 |
| 27 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.19408152 |
| 28 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.18318078 |
| 29 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.15435930 |
| 30 | ABC transporters_Homo sapiens_hsa02010 | 1.13054372 |
| 31 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.11738866 |
| 32 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.10908974 |
| 33 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.02305109 |
| 34 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.02289625 |
| 35 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.87771109 |
| 36 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.84827421 |
| 37 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.83232340 |
| 38 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.81469712 |
| 39 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.78626569 |
| 40 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.77977701 |
| 41 | Asthma_Homo sapiens_hsa05310 | 0.76582725 |
| 42 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.73142056 |
| 43 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.69843476 |
| 44 | Retinol metabolism_Homo sapiens_hsa00830 | 0.61447610 |
| 45 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.60833431 |
| 46 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.59799347 |
| 47 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.56338273 |
| 48 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.55665436 |
| 49 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.54909304 |
| 50 | Allograft rejection_Homo sapiens_hsa05330 | 0.53966078 |
| 51 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.53947592 |
| 52 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.53400305 |
| 53 | Tight junction_Homo sapiens_hsa04530 | 0.52728380 |
| 54 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.51295795 |
| 55 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.50527941 |
| 56 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.49618776 |
| 57 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.49435295 |
| 58 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.49341964 |
| 59 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.48012960 |
| 60 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.47180237 |
| 61 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.45681470 |
| 62 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.43284664 |
| 63 | Carbon metabolism_Homo sapiens_hsa01200 | 0.41151653 |
| 64 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.40929399 |
| 65 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.40858472 |
| 66 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.40457645 |
| 67 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.36828654 |
| 68 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.36327970 |
| 69 | Insulin secretion_Homo sapiens_hsa04911 | 0.33601013 |
| 70 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.33359215 |
| 71 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.28435670 |
| 72 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.28278069 |
| 73 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.27953432 |
| 74 | Metabolic pathways_Homo sapiens_hsa01100 | 0.26167173 |
| 75 | Lysine degradation_Homo sapiens_hsa00310 | 0.25295491 |
| 76 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.24787792 |
| 77 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.24652512 |
| 78 | Adherens junction_Homo sapiens_hsa04520 | 0.23619030 |
| 79 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.22647208 |
| 80 | Peroxisome_Homo sapiens_hsa04146 | 0.22625387 |
| 81 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.22461607 |
| 82 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.22271453 |
| 83 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.21802495 |
| 84 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.20125026 |
| 85 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.20122478 |
| 86 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.19738336 |
| 87 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.19632003 |
| 88 | Salmonella infection_Homo sapiens_hsa05132 | 0.18844045 |
| 89 | Thyroid cancer_Homo sapiens_hsa05216 | 0.18673206 |
| 90 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.16746639 |
| 91 | Hepatitis C_Homo sapiens_hsa05160 | 0.15822918 |
| 92 | Salivary secretion_Homo sapiens_hsa04970 | 0.15466324 |
| 93 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.14682804 |
| 94 | Renin secretion_Homo sapiens_hsa04924 | 0.13881811 |
| 95 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.13644378 |
| 96 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.12960450 |
| 97 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.12421793 |
| 98 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.12417681 |
| 99 | Other glycan degradation_Homo sapiens_hsa00511 | 0.12325145 |
| 100 | Pertussis_Homo sapiens_hsa05133 | 0.10462216 |
| 101 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.10073534 |
| 102 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.09884955 |
| 103 | Cocaine addiction_Homo sapiens_hsa05030 | 0.07699621 |
| 104 | Sulfur relay system_Homo sapiens_hsa04122 | 0.07475547 |
| 105 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.07419287 |
| 106 | Leishmaniasis_Homo sapiens_hsa05140 | 0.07059859 |
| 107 | Insulin resistance_Homo sapiens_hsa04931 | 0.06895972 |
| 108 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.06212241 |
| 109 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.05637846 |
| 110 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.05635803 |
| 111 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.05401526 |
| 112 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.03774800 |
| 113 | Bladder cancer_Homo sapiens_hsa05219 | 0.03262349 |
| 114 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.02762619 |
| 115 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.02738553 |
| 116 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.02679080 |
| 117 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.00592905 |
| 118 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.00402349 |
| 119 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.00335996 |
| 120 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | -0.0319129 |
| 121 | Influenza A_Homo sapiens_hsa05164 | -0.0294259 |
| 122 | Amphetamine addiction_Homo sapiens_hsa05031 | -0.0249317 |
| 123 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | -0.0182320 |
| 124 | Legionellosis_Homo sapiens_hsa05134 | -0.0180447 |

