HNMT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.88349911
2L-phenylalanine catabolic process (GO:0006559)4.88349911
3very-low-density lipoprotein particle assembly (GO:0034379)4.87660640
4cholesterol efflux (GO:0033344)4.59937641
5plasma lipoprotein particle clearance (GO:0034381)4.59814899
6plasma lipoprotein particle assembly (GO:0034377)4.56395129
7regulation of apoptotic cell clearance (GO:2000425)4.48581954
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.43576964
9L-phenylalanine metabolic process (GO:0006558)4.43576964
10negative regulation of protein activation cascade (GO:2000258)4.34500016
11protein-lipid complex assembly (GO:0065005)4.13566545
12negative regulation of cholesterol transport (GO:0032375)4.12101193
13negative regulation of sterol transport (GO:0032372)4.12101193
14plasma lipoprotein particle organization (GO:0071827)4.02480162
15aromatic amino acid family catabolic process (GO:0009074)4.01202811
16phospholipid efflux (GO:0033700)3.95023567
17negative regulation of complement activation (GO:0045916)3.92351115
18regulation of macrophage chemotaxis (GO:0010758)3.91167080
19ethanol oxidation (GO:0006069)3.90811692
20positive regulation of triglyceride lipase activity (GO:0061365)3.89693746
21positive regulation of lipoprotein lipase activity (GO:0051006)3.89693746
22fibrinolysis (GO:0042730)3.88752257
23negative regulation of synaptic transmission, GABAergic (GO:0032229)3.83598753
24protein-lipid complex subunit organization (GO:0071825)3.82386690
25low-density lipoprotein particle clearance (GO:0034383)3.76721340
26protein activation cascade (GO:0072376)3.70790041
27fatty acid elongation (GO:0030497)3.69645526
28reverse cholesterol transport (GO:0043691)3.66161689
29coenzyme catabolic process (GO:0009109)3.63122050
30intestinal cholesterol absorption (GO:0030299)3.62057398
31acute-phase response (GO:0006953)3.61455696
32complement activation, classical pathway (GO:0006958)3.60273034
33positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.57028434
34bile acid biosynthetic process (GO:0006699)3.54121627
35complement activation (GO:0006956)3.53848056
36regulation of cholesterol storage (GO:0010885)3.51526096
37negative regulation of hemostasis (GO:1900047)3.47089710
38negative regulation of blood coagulation (GO:0030195)3.47089710
39lipoprotein metabolic process (GO:0042157)3.41748917
40positive regulation of extracellular matrix organization (GO:1903055)3.37577694
41positive regulation of hemostasis (GO:1900048)3.37483698
42positive regulation of blood coagulation (GO:0030194)3.37483698
43negative regulation of coagulation (GO:0050819)3.36574136
44cellular ketone body metabolic process (GO:0046950)3.33530756
45alpha-linolenic acid metabolic process (GO:0036109)3.31319577
46regulation of humoral immune response (GO:0002920)3.28997097
47indole-containing compound catabolic process (GO:0042436)3.27457654
48indolalkylamine catabolic process (GO:0046218)3.27457654
49tryptophan catabolic process (GO:0006569)3.27457654
50neuron cell-cell adhesion (GO:0007158)3.26779924
51epoxygenase P450 pathway (GO:0019373)3.26432424
52negative regulation of humoral immune response (GO:0002921)3.25706366
53triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.24511123
54regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.21620877
55positive regulation of coagulation (GO:0050820)3.21402950
56cholesterol transport (GO:0030301)3.18249807
57sterol transport (GO:0015918)3.18249807
58ethanol metabolic process (GO:0006067)3.15694124
59presynaptic membrane assembly (GO:0097105)3.15611945
60positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.13408398
61fat-soluble vitamin biosynthetic process (GO:0042362)3.13278685
62synaptic vesicle exocytosis (GO:0016079)3.13194585
63gamma-aminobutyric acid transport (GO:0015812)3.11163027
64oligosaccharide catabolic process (GO:0009313)3.09939069
65kynurenine metabolic process (GO:0070189)3.05962866
66very long-chain fatty acid metabolic process (GO:0000038)3.04974706
67regulation of plasminogen activation (GO:0010755)3.04382790
68tryptophan metabolic process (GO:0006568)3.04329465
69glutamate metabolic process (GO:0006536)3.04311180
70detection of molecule of bacterial origin (GO:0032490)3.03333652
71dopamine transport (GO:0015872)3.03015816
72succinate metabolic process (GO:0006105)3.02485154
73cofactor catabolic process (GO:0051187)3.01029672
74tyrosine metabolic process (GO:0006570)3.00327154
75triglyceride homeostasis (GO:0070328)3.00019155
76acylglycerol homeostasis (GO:0055090)3.00019155
77intestinal absorption (GO:0050892)2.99668711
78presynaptic membrane organization (GO:0097090)2.98984989
79dicarboxylic acid catabolic process (GO:0043649)2.96275106
80vocalization behavior (GO:0071625)2.96190273
81regulation of mononuclear cell migration (GO:0071675)2.95598354
82positive regulation of fatty acid biosynthetic process (GO:0045723)2.93577454
83negative regulation of wound healing (GO:0061045)2.92759062
84exogenous drug catabolic process (GO:0042738)2.92176170
85bile acid metabolic process (GO:0008206)2.91225140
86mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.90391622
87complement activation, alternative pathway (GO:0006957)2.89102596
88gamma-aminobutyric acid signaling pathway (GO:0007214)2.88042911
89neuronal action potential propagation (GO:0019227)2.87865807
90acute inflammatory response (GO:0002526)2.87744758
91regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.86640193
92ketone body metabolic process (GO:1902224)2.86617500
93aromatic amino acid family metabolic process (GO:0009072)2.86385603
94glyoxylate metabolic process (GO:0046487)2.86219553
95sulfur amino acid catabolic process (GO:0000098)2.85266832
96positive regulation of chemokine secretion (GO:0090197)2.85013240
97glycosphingolipid catabolic process (GO:0046479)2.85009690
98cholesterol homeostasis (GO:0042632)2.84517555
99ionotropic glutamate receptor signaling pathway (GO:0035235)2.84094615
100phospholipid homeostasis (GO:0055091)2.81881970
101drug catabolic process (GO:0042737)2.81548875
102high-density lipoprotein particle remodeling (GO:0034375)2.81511017
103aldehyde catabolic process (GO:0046185)2.79907195
104glutamate receptor signaling pathway (GO:0007215)2.79454830
105sterol homeostasis (GO:0055092)2.79400115
106urea metabolic process (GO:0019627)2.78914500
107urea cycle (GO:0000050)2.78914500
108blood coagulation, intrinsic pathway (GO:0007597)2.78172632
109cellular glucuronidation (GO:0052695)2.77187184
110omega-hydroxylase P450 pathway (GO:0097267)2.76135472
111regulation of cholesterol homeostasis (GO:2000188)2.75697296
112lipoprotein transport (GO:0042953)2.75615201
113alpha-amino acid catabolic process (GO:1901606)2.75324978
114cysteine metabolic process (GO:0006534)2.74930630
115negative regulation of neurotransmitter transport (GO:0051589)2.74889098
116positive regulation of lipid storage (GO:0010884)2.74451322
117neurotransmitter-gated ion channel clustering (GO:0072578)2.74122688
118regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.74085231
119positive regulation of phagocytosis (GO:0050766)2.73432852
120opsonization (GO:0008228)2.72597031
121cellular response to thyroid hormone stimulus (GO:0097067)2.71336852
122fatty-acyl-CoA metabolic process (GO:0035337)2.71322177
123positive regulation of steroid metabolic process (GO:0045940)2.70716120
124uronic acid metabolic process (GO:0006063)2.70259003
125glucuronate metabolic process (GO:0019585)2.70259003
126regulation of acute inflammatory response (GO:0002673)2.69836009
127diacylglycerol metabolic process (GO:0046339)2.68942889
128regulation of fibrinolysis (GO:0051917)2.67817419
129fatty-acyl-CoA biosynthetic process (GO:0046949)2.67060544
130regulation of macrophage derived foam cell differentiation (GO:0010743)2.66299164
131regulation of protein activation cascade (GO:2000257)2.65851136
132cellular amino acid catabolic process (GO:0009063)2.65795595
133regulation of triglyceride catabolic process (GO:0010896)2.65683430
134regulation of glutamate secretion (GO:0014048)2.65285894
135positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.65220968
136dicarboxylic acid biosynthetic process (GO:0043650)2.65039288
137angiotensin maturation (GO:0002003)2.64904034
138long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.64073498
139short-chain fatty acid metabolic process (GO:0046459)2.64059508
140low-density lipoprotein particle remodeling (GO:0034374)2.63865347
141aspartate family amino acid catabolic process (GO:0009068)2.63684591
142behavioral response to cocaine (GO:0048148)2.63592726
143acylglycerol catabolic process (GO:0046464)2.62957524
144neuron-neuron synaptic transmission (GO:0007270)2.62392880
145plasma lipoprotein particle remodeling (GO:0034369)2.61973358
146protein-lipid complex remodeling (GO:0034368)2.61973358
147macromolecular complex remodeling (GO:0034367)2.61973358
148response to histamine (GO:0034776)2.61792870
149peroxisome fission (GO:0016559)2.61359155
150ATP hydrolysis coupled proton transport (GO:0015991)2.61270134
151energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.61270134
152acyl-CoA metabolic process (GO:0006637)2.60952888
153thioester metabolic process (GO:0035383)2.60952888
154negative regulation of fibrinolysis (GO:0051918)2.57502880
155nitrogen cycle metabolic process (GO:0071941)2.57495043
156lysine catabolic process (GO:0006554)2.57179127
157lysine metabolic process (GO:0006553)2.57179127
158glutamate secretion (GO:0014047)2.57060988
159fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.55984471
160long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.55940693
161oxaloacetate metabolic process (GO:0006107)2.55853279
162peptidyl-glutamic acid carboxylation (GO:0017187)2.55467548
163protein carboxylation (GO:0018214)2.55467548
164acyl-CoA biosynthetic process (GO:0071616)2.55424795
165thioester biosynthetic process (GO:0035384)2.55424795
166indolalkylamine metabolic process (GO:0006586)2.55041354
167neurotransmitter uptake (GO:0001504)2.54374776
168regulation of glutamate receptor signaling pathway (GO:1900449)2.54226011
169chaperone-mediated protein transport (GO:0072321)2.53093309
170regulation of cholesterol esterification (GO:0010872)2.52803081
171NADH metabolic process (GO:0006734)2.51110775
172amine catabolic process (GO:0009310)2.50011528
173cellular biogenic amine catabolic process (GO:0042402)2.50011528
174regulation of synaptic vesicle exocytosis (GO:2000300)2.49515680
175respiratory electron transport chain (GO:0022904)2.49274589
176protein localization to synapse (GO:0035418)2.48945086
177regulation of complement activation (GO:0030449)2.48524496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.02632068
2GBX2_23144817_ChIP-Seq_PC3_Human3.90081411
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.59722449
4TAF15_26573619_Chip-Seq_HEK293_Human3.57049599
5EZH2_22144423_ChIP-Seq_EOC_Human3.47144454
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.75474608
7* RXR_22158963_ChIP-Seq_LIVER_Mouse2.69609609
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.56219325
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.51227299
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45163812
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.40405094
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38555069
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32075630
14* FOXA2_19822575_ChIP-Seq_HepG2_Human2.31208075
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.27580617
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.26446944
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26343385
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.24457432
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.16115905
20* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14146336
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.10253879
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09102645
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08837433
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06464391
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03595494
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02156451
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94236980
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94170805
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.92030141
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90807896
31* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86663393
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.84229798
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83977800
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.83714331
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82533784
36* P300_19829295_ChIP-Seq_ESCs_Human1.81184332
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.77028261
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.75168306
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.75168306
40VDR_24787735_ChIP-Seq_THP-1_Human1.75003396
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.73537434
42REST_21632747_ChIP-Seq_MESCs_Mouse1.71241503
43* HNF4A_19822575_ChIP-Seq_HepG2_Human1.66358541
44CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.64194263
45SMAD4_21799915_ChIP-Seq_A2780_Human1.63590053
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61929912
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61774262
48HTT_18923047_ChIP-ChIP_STHdh_Human1.60205743
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59901729
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.59337322
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58034403
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58020529
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57498000
54AR_21572438_ChIP-Seq_LNCaP_Human1.56996895
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.55784462
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.54816434
57* SOX2_20726797_ChIP-Seq_SW620_Human1.54658533
58* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54595848
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52040655
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.46884180
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.46566775
62CDX2_20551321_ChIP-Seq_CACO-2_Human1.46461292
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.44847232
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43887612
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43551950
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43304983
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.40222283
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40172713
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39838646
70VDR_22108803_ChIP-Seq_LS180_Human1.38841522
71ER_23166858_ChIP-Seq_MCF-7_Human1.38812822
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38541722
73FUS_26573619_Chip-Seq_HEK293_Human1.36822970
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.36533762
75* AR_25329375_ChIP-Seq_VCAP_Human1.36200466
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.35634166
77EZH2_27294783_Chip-Seq_ESCs_Mouse1.34847608
78* GATA4_25053715_ChIP-Seq_YYC3_Human1.34642717
79CLOCK_20551151_ChIP-Seq_293T_Human1.34595098
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33679895
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33221039
82* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31794357
83FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31671560
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31057885
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29442475
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29442475
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28821881
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28632455
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28171594
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.27567464
91NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26996374
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25361619
93TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.25028634
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23975765
95* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23821389
96RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22739832
97PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21453749
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19896335
99* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19837518
100GATA1_22025678_ChIP-Seq_K562_Human1.19092958
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18863375
102* RARB_27405468_Chip-Seq_BRAIN_Mouse1.18141851
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17556838
104STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.16882055
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16347533
106FOXO3_23340844_ChIP-Seq_DLD1_Human1.16305366
107RNF2_27304074_Chip-Seq_ESCs_Mouse1.13434651
108IGF1R_20145208_ChIP-Seq_DFB_Human1.13397627
109BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12268085
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.11574238
111FLI1_27457419_Chip-Seq_LIVER_Mouse1.11464280
112PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11392430
113* CJUN_26792858_Chip-Seq_BT549_Human1.10793179
114BCAT_22108803_ChIP-Seq_LS180_Human1.10485503
115* SOX2_21211035_ChIP-Seq_LN229_Gbm1.09920718
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08171293
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06180813
118* NANOG_18555785_Chip-Seq_ESCs_Mouse1.06047569
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05358652
120SPI1_23127762_ChIP-Seq_K562_Human1.04926037
121CBX2_27304074_Chip-Seq_ESCs_Mouse1.04673516
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04271463
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.04012247
124* KDM2B_26808549_Chip-Seq_REH_Human1.02911382
125CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02463425
126JUN_21703547_ChIP-Seq_K562_Human1.02244264
127ZNF274_21170338_ChIP-Seq_K562_Hela1.02141500
128STAT3_23295773_ChIP-Seq_U87_Human1.01443705
129ERG_21242973_ChIP-ChIP_JURKAT_Human1.01396185
130PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01201809
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99637282
132TCF4_18268006_ChIP-ChIP_LS174T_Human0.99632864
133SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99447098
134NANOG_19829295_ChIP-Seq_ESCs_Human0.98471035
135SOX2_19829295_ChIP-Seq_ESCs_Human0.98471035
136* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97677788
137IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96609552
138* P53_22387025_ChIP-Seq_ESCs_Mouse0.95900131
139DROSHA_22980978_ChIP-Seq_HELA_Human0.95805421
140TAL1_26923725_Chip-Seq_HPCs_Mouse0.94423403
141CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94096021
142RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93849466
143* RUNX2_22187159_ChIP-Seq_PCA_Human0.93074056
144RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92884827
145* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92751336
146MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92168777
147FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90903635
148* TCF4_23295773_ChIP-Seq_U87_Human0.90820709
149CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90346926
150E2F1_18555785_Chip-Seq_ESCs_Mouse0.90081619
151AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89764737
152MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89394892
153PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89340704
154NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89301524
155CBP_20019798_ChIP-Seq_JUKART_Human0.88919195
156FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88410835
157* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86977257
158PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84957998
159PU_27001747_Chip-Seq_BMDM_Mouse0.84457524
160LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83432030
161CDX2_22108803_ChIP-Seq_LS180_Human0.82749349
162GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82521600
163ESR1_20079471_ChIP-ChIP_T-47D_Human0.82348498
164EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82326185
165IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.82038304
166CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81533254
167BRD4_27068464_Chip-Seq_AML-cells_Mouse0.80600557
168JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80546450
169CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80199615
170PU1_27457419_Chip-Seq_LIVER_Mouse0.78404283
171SUZ12_27294783_Chip-Seq_NPCs_Mouse0.78060651
172EP300_21415370_ChIP-Seq_HL-1_Mouse0.76695853
173EZH2_27294783_Chip-Seq_NPCs_Mouse0.75055061
174STAT4_19710469_ChIP-ChIP_TH1__Mouse0.73748718
175GATA1_19941827_ChIP-Seq_MEL_Mouse0.73433445
176SMAD1_18555785_Chip-Seq_ESCs_Mouse0.72585047
177CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72107487
178RUNX_20019798_ChIP-Seq_JUKART_Human0.72067201
179CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.71557956
180NFE2_27457419_Chip-Seq_LIVER_Mouse0.70981047
181* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70577103
182TP53_16413492_ChIP-PET_HCT116_Human0.70003258
183STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.69620727

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.52340301
2MP0003880_abnormal_central_pattern4.21503141
3MP0005360_urolithiasis3.93166075
4MP0008875_abnormal_xenobiotic_pharmacok3.55777290
5MP0005058_abnormal_lysosome_morphology3.45093434
6MP0005085_abnormal_gallbladder_physiolo3.37747460
7MP0005365_abnormal_bile_salt3.23167447
8MP0004859_abnormal_synaptic_plasticity2.92362687
9MP0002736_abnormal_nociception_after2.71894735
10MP0003635_abnormal_synaptic_transmissio2.51894865
11MP0001968_abnormal_touch/_nociception2.50653017
12MP0009745_abnormal_behavioral_response2.42351406
13MP0002064_seizures2.32710375
14MP0003806_abnormal_nucleotide_metabolis2.27225914
15MP0003172_abnormal_lysosome_physiology2.26542371
16MP0006082_CNS_inflammation2.19967507
17MP0010329_abnormal_lipoprotein_level2.15065283
18MP0005167_abnormal_blood-brain_barrier2.14435715
19MP0002837_dystrophic_cardiac_calcinosis2.14103708
20MP0002063_abnormal_learning/memory/cond2.06151175
21MP0001501_abnormal_sleep_pattern2.05272784
22MP0002822_catalepsy2.03646076
23MP0006054_spinal_hemorrhage2.01249190
24MP0004270_analgesia2.00196231
25MP0003303_peritoneal_inflammation1.98257094
26MP0002572_abnormal_emotion/affect_behav1.98143952
27MP0009046_muscle_twitch1.95930540
28MP0001529_abnormal_vocalization1.95392951
29MP0002272_abnormal_nervous_system1.94789749
30MP0003329_amyloid_beta_deposits1.90413049
31MP0003195_calcinosis1.87379842
32MP0009785_altered_susceptibility_to1.86046134
33MP0006276_abnormal_autonomic_nervous1.83983534
34MP0002876_abnormal_thyroid_physiology1.81982269
35MP0001440_abnormal_grooming_behavior1.79804963
36MP0003436_decreased_susceptibility_to1.76719409
37MP0002138_abnormal_hepatobiliary_system1.76029209
38MP0001486_abnormal_startle_reflex1.72807355
39MP0005332_abnormal_amino_acid1.72059157
40MP0001905_abnormal_dopamine_level1.70998043
41MP0004142_abnormal_muscle_tone1.70468933
42MP0002419_abnormal_innate_immunity1.66909733
43MP0002733_abnormal_thermal_nociception1.60892528
44MP0005408_hypopigmentation1.59649985
45MP0005670_abnormal_white_adipose1.58570836
46MP0002148_abnormal_hypersensitivity_rea1.54640414
47MP0005535_abnormal_body_temperature1.53318621
48MP0005646_abnormal_pituitary_gland1.53192823
49MP0000604_amyloidosis1.52065010
50MP0005464_abnormal_platelet_physiology1.50362042
51MP0002735_abnormal_chemical_nociception1.49687607
52MP0003300_gastrointestinal_ulcer1.49605273
53MP0000343_altered_response_to1.49040492
54MP0005083_abnormal_biliary_tract1.48780516
55MP0005164_abnormal_response_to1.46125439
56MP0002067_abnormal_sensory_capabilities1.44690441
57MP0001970_abnormal_pain_threshold1.44399557
58MP0002118_abnormal_lipid_homeostasis1.40413669
59MP0003252_abnormal_bile_duct1.38606748
60MP0001533_abnormal_skeleton_physiology1.38014539
61MP0003690_abnormal_glial_cell1.37143200
62MP0003191_abnormal_cellular_cholesterol1.36756987
63MP0005025_abnormal_response_to1.36100520
64MP0008469_abnormal_protein_level1.35948754
65MP0002734_abnormal_mechanical_nocicepti1.34996212
66MP0009764_decreased_sensitivity_to1.34736439
67MP0005584_abnormal_enzyme/coenzyme_acti1.32439210
68MP0000920_abnormal_myelination1.31317515
69MP0004883_abnormal_blood_vessel1.29821893
70MP0004924_abnormal_behavior1.27289190
71MP0005386_behavior/neurological_phenoty1.27289190
72MP0002998_abnormal_bone_remodeling1.26422090
73MP0001835_abnormal_antigen_presentation1.24860218
74MP0003868_abnormal_feces_composition1.23704634
75MP0001666_abnormal_nutrient_absorption1.23363285
76MP0006036_abnormal_mitochondrial_physio1.21955139
77MP0001790_abnormal_immune_system1.20209130
78MP0005387_immune_system_phenotype1.20209130
79MP0008874_decreased_physiological_sensi1.17269731
80MP0000685_abnormal_immune_system1.16865773
81MP0001764_abnormal_homeostasis1.16397368
82MP0003633_abnormal_nervous_system1.15002448
83MP0002971_abnormal_brown_adipose1.14941498
84MP0009697_abnormal_copulation1.14806043
85MP0003950_abnormal_plasma_membrane1.13741241
86MP0001845_abnormal_inflammatory_respons1.07702682
87MP0003011_delayed_dark_adaptation1.07038930
88MP0009115_abnormal_fat_cell1.06395220
89MP0005166_decreased_susceptibility_to1.04182179
90MP0008872_abnormal_physiological_respon1.04102070
91MP0002132_abnormal_respiratory_system1.03528495
92MP0003631_nervous_system_phenotype1.02280817
93MP0001853_heart_inflammation1.01323211
94MP0004130_abnormal_muscle_cell1.00256323
95MP0009643_abnormal_urine_homeostasis0.99072753
96MP0003879_abnormal_hair_cell0.99064510
97MP0004043_abnormal_pH_regulation0.97403563
98MP0005171_absent_coat_pigmentation0.97258127
99MP0010368_abnormal_lymphatic_system0.96298867
100MP0002066_abnormal_motor_capabilities/c0.96285067
101MP0000249_abnormal_blood_vessel0.94814904
102MP0005423_abnormal_somatic_nervous0.94768748
103MP0001756_abnormal_urination0.94523684
104MP0004885_abnormal_endolymph0.93961570
105MP0003656_abnormal_erythrocyte_physiolo0.93551831
106MP0005000_abnormal_immune_tolerance0.93255069
107MP0009780_abnormal_chondrocyte_physiolo0.92828986
108MP0002557_abnormal_social/conspecific_i0.92424617
109MP0004147_increased_porphyrin_level0.92148588
110MP0000858_altered_metastatic_potential0.92138477
111MP0005257_abnormal_intraocular_pressure0.91403607
112MP0002933_joint_inflammation0.90503846
113MP0000013_abnormal_adipose_tissue0.89500097
114MP0003122_maternal_imprinting0.88968757
115MP0000371_diluted_coat_color0.88951476
116MP0002229_neurodegeneration0.88475328
117MP0009840_abnormal_foam_cell0.88458086
118MP0001915_intracranial_hemorrhage0.87914360
119MP0009763_increased_sensitivity_to0.87236615
120MP0003136_yellow_coat_color0.86348896
121MP0003828_pulmonary_edema0.85686984
122MP0002909_abnormal_adrenal_gland0.84643605
123MP0008438_abnormal_cutaneous_collagen0.83317713
124MP0003183_abnormal_peptide_metabolism0.82482858
125MP0001664_abnormal_digestion0.81822992
126MP0002452_abnormal_antigen_presenting0.81654679
127MP0001502_abnormal_circadian_rhythm0.80480399
128MP0004019_abnormal_vitamin_homeostasis0.80255615
129MP0001661_extended_life_span0.79792982
130MP0000609_abnormal_liver_physiology0.78373074
131MP0001986_abnormal_taste_sensitivity0.78227610
132MP0002184_abnormal_innervation0.78141072
133MP0003632_abnormal_nervous_system0.76947152
134MP0005023_abnormal_wound_healing0.76909499
135MP0002405_respiratory_system_inflammati0.76753832
136MP0005671_abnormal_response_to0.76406163
137MP0005319_abnormal_enzyme/_coenzyme0.76088110
138MP0003075_altered_response_to0.76024040
139MP0001984_abnormal_olfaction0.75912594
140MP0005165_increased_susceptibility_to0.75499912
141MP0002332_abnormal_exercise_endurance0.75368352
142MP0003186_abnormal_redox_activity0.75015433
143MP0008569_lethality_at_weaning0.74787214
144MP0002723_abnormal_immune_serum0.74759272
145MP0000639_abnormal_adrenal_gland0.74144875
146MP0005647_abnormal_sex_gland0.73892399
147MP0010386_abnormal_urinary_bladder0.73804394
148MP0005551_abnormal_eye_electrophysiolog0.73703732
149MP0010155_abnormal_intestine_physiology0.73189180
150MP0000778_abnormal_nervous_system0.72702476
151MP0003724_increased_susceptibility_to0.72689948
152MP0006035_abnormal_mitochondrial_morpho0.72343620
153MP0005376_homeostasis/metabolism_phenot0.72278839
154MP0005636_abnormal_mineral_homeostasis0.71585870
155MP0000230_abnormal_systemic_arterial0.70486908
156MP0005451_abnormal_body_composition0.69852723
157MP0005645_abnormal_hypothalamus_physiol0.68928331
158MP0002069_abnormal_eating/drinking_beha0.68743187
159MP0005084_abnormal_gallbladder_morpholo0.68384568
160MP0000598_abnormal_liver_morphology0.67377611
161MP0009642_abnormal_blood_homeostasis0.67364384
162MP0001800_abnormal_humoral_immune0.66405542
163MP0001324_abnormal_eye_pigmentation0.64963318
164MP0005334_abnormal_fat_pad0.64689271
165MP0001958_emphysema0.64477632
166MP0008004_abnormal_stomach_pH0.63655037
167MP0005397_hematopoietic_system_phenotyp0.63340623

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.23994536
2Glomerulonephritis (HP:0000099)5.99221589
3Prolonged partial thromboplastin time (HP:0003645)4.96687504
4Focal motor seizures (HP:0011153)4.80750014
5Abnormality of liposaccharide metabolism (HP:0010968)4.52699528
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.52699528
7Abnormality of glycolipid metabolism (HP:0010969)4.52699528
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.44385488
9Hyperventilation (HP:0002883)4.43353163
10Recurrent gram-negative bacterial infections (HP:0005420)4.30864785
11Vacuolated lymphocytes (HP:0001922)3.90938881
12Hypobetalipoproteinemia (HP:0003563)3.58632087
13Deep venous thrombosis (HP:0002625)3.57032471
14Purpura (HP:0000979)3.56712895
15Joint hemorrhage (HP:0005261)3.52046864
16Nephritis (HP:0000123)3.51423623
17Myocardial infarction (HP:0001658)3.48243005
18Intrahepatic cholestasis (HP:0001406)3.47790869
19Dysostosis multiplex (HP:0000943)3.34227358
20Acute encephalopathy (HP:0006846)3.28536161
21Hyperlipoproteinemia (HP:0010980)3.25792199
22Acute necrotizing encephalopathy (HP:0006965)3.17445340
23Atonic seizures (HP:0010819)3.17405049
24Cerebral edema (HP:0002181)3.16434522
25Abnormality of polysaccharide metabolism (HP:0011012)3.14272032
26Abnormality of glycosaminoglycan metabolism (HP:0004371)3.14272032
27Abnormality of mucopolysaccharide metabolism (HP:0011020)3.14272032
28Myokymia (HP:0002411)3.13001900
29Urinary glycosaminoglycan excretion (HP:0003541)3.09073535
30Mucopolysacchariduria (HP:0008155)3.09073535
31Hypercholesterolemia (HP:0003124)3.07388327
32Epileptic encephalopathy (HP:0200134)3.06127254
33Xanthomatosis (HP:0000991)3.05315263
34Abnormal mitochondria in muscle tissue (HP:0008316)3.04094457
35Complement deficiency (HP:0004431)2.99880994
36Gingival bleeding (HP:0000225)2.95530088
37Focal seizures (HP:0007359)2.93680738
38Increased cerebral lipofuscin (HP:0011813)2.92364109
39Abnormal gallbladder physiology (HP:0012438)2.92148548
40Cholecystitis (HP:0001082)2.92148548
41Hemorrhage of the eye (HP:0011885)2.89777015
42Abnormality of macrophages (HP:0004311)2.85389230
43Mitochondrial inheritance (HP:0001427)2.84249491
44Neurofibrillary tangles (HP:0002185)2.84051378
45Progressive macrocephaly (HP:0004481)2.81187744
46Pheochromocytoma (HP:0002666)2.78998346
47Ketosis (HP:0001946)2.77513938
48Cerebral inclusion bodies (HP:0100314)2.77051353
49Neuroendocrine neoplasm (HP:0100634)2.71707229
50Cerebral hemorrhage (HP:0001342)2.71050846
51Hepatocellular necrosis (HP:0001404)2.70732917
52Abnormality of monocarboxylic acid metabolism (HP:0010996)2.67633731
53Hyperammonemia (HP:0001987)2.59560400
54Absence seizures (HP:0002121)2.59430790
55Hyperglycinemia (HP:0002154)2.59267699
56Vascular calcification (HP:0004934)2.58435845
57Abnormality of the intrinsic pathway (HP:0010989)2.57899943
58Mitral stenosis (HP:0001718)2.53841863
59Generalized tonic-clonic seizures (HP:0002069)2.52949680
60Dialeptic seizures (HP:0011146)2.52606203
61Eczematoid dermatitis (HP:0000976)2.52409550
62Hypothermia (HP:0002045)2.51813967
63Hepatic necrosis (HP:0002605)2.51239592
64Disinhibition (HP:0000734)2.49662857
65Lethargy (HP:0001254)2.48042744
66Skin nodule (HP:0200036)2.47856895
67Loss of speech (HP:0002371)2.47167859
68Orchitis (HP:0100796)2.44657672
69Increased CSF lactate (HP:0002490)2.44428997
70Abnormality of serine family amino acid metabolism (HP:0010894)2.43580884
71Abnormality of glycine metabolism (HP:0010895)2.43580884
72Abnormality of methionine metabolism (HP:0010901)2.43462564
73Thrombophlebitis (HP:0004418)2.38561188
74Increased serum pyruvate (HP:0003542)2.37830428
75Abnormality of glycolysis (HP:0004366)2.37830428
76Recurrent abscess formation (HP:0002722)2.36479187
77Retrobulbar optic neuritis (HP:0100654)2.35774983
78Optic neuritis (HP:0100653)2.35774983
79Spontaneous abortion (HP:0005268)2.34051738
80Increased neuronal autofluorescent lipopigment (HP:0002074)2.33881159
81Cardiovascular calcification (HP:0011915)2.33204555
82Hypolipoproteinemia (HP:0010981)2.32532908
83Abnormality of aspartate family amino acid metabolism (HP:0010899)2.31755699
84Metaphyseal irregularity (HP:0003025)2.30595621
85Renal Fanconi syndrome (HP:0001994)2.29900827
86Pulmonary embolism (HP:0002204)2.29550367
87Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.29548195
88Visual hallucinations (HP:0002367)2.29396275
89Recurrent bacterial skin infections (HP:0005406)2.29325881
90Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.28448201
91Steatorrhea (HP:0002570)2.26440553
92Abnormality of glutamine family amino acid metabolism (HP:0010902)2.23864713
93Febrile seizures (HP:0002373)2.23742268
94Methylmalonic acidemia (HP:0002912)2.23242935
95Potter facies (HP:0002009)2.21633421
96Facial shape deformation (HP:0011334)2.21633421
97Epidermoid cyst (HP:0200040)2.21141928
98Mutism (HP:0002300)2.20280202
99Status epilepticus (HP:0002133)2.19785314
100Sensorimotor neuropathy (HP:0007141)2.19275673
101Anxiety (HP:0000739)2.18507629
102Menorrhagia (HP:0000132)2.17557515
103Conjugated hyperbilirubinemia (HP:0002908)2.17234841
104Myositis (HP:0100614)2.16186029
105Retinal atrophy (HP:0001105)2.15445307
106Axonal loss (HP:0003447)2.15237112
107Fat malabsorption (HP:0002630)2.14605548
108Lipid accumulation in hepatocytes (HP:0006561)2.13789136
109Abnormality of fatty-acid metabolism (HP:0004359)2.13294781
110Lactic acidosis (HP:0003128)2.12616781
111Hyperglycinuria (HP:0003108)2.12484825
112Increased serum ferritin (HP:0003281)2.12170297
113Increased intramyocellular lipid droplets (HP:0012240)2.11451151
114Ketoacidosis (HP:0001993)2.11425084
115Hypoalphalipoproteinemia (HP:0003233)2.09613313
116Abnormality of the common coagulation pathway (HP:0010990)2.09570567
117Spastic paraparesis (HP:0002313)2.06741315
118Increased muscle lipid content (HP:0009058)2.06680907
119Rickets (HP:0002748)2.06278044
120Increased hepatocellular lipid droplets (HP:0006565)2.05582530
121Amyloidosis (HP:0011034)2.05489431
122Abnormality of proline metabolism (HP:0010907)2.04614535
123Hydroxyprolinuria (HP:0003080)2.04614535
124Oligomenorrhea (HP:0000876)2.04529495
125Abnormality of the vasculature of the conjunctiva (HP:0008054)2.03997043
126Leukodystrophy (HP:0002415)2.03491390
127Esophageal varix (HP:0002040)2.03289687
128Generalized aminoaciduria (HP:0002909)2.01930592
129Blue irides (HP:0000635)2.01780064
130Methylmalonic aciduria (HP:0012120)2.00392397
131Abnormality of carpal bone ossification (HP:0006257)2.00361343
132Abnormal gallbladder morphology (HP:0012437)1.99969203
133Flared iliac wings (HP:0002869)1.99368069
134Vomiting (HP:0002013)1.97670406
135Ovoid vertebral bodies (HP:0003300)1.96951089
136Dysmetria (HP:0001310)1.96506370
137Progressive inability to walk (HP:0002505)1.95475947
138Metabolic acidosis (HP:0001942)1.95438164
139Abnormality of iron homeostasis (HP:0011031)1.93903525
140Cholelithiasis (HP:0001081)1.93898795
141Generalized myoclonic seizures (HP:0002123)1.93654032
142Vertebral compression fractures (HP:0002953)1.93632359
143Epistaxis (HP:0000421)1.92886605
144Esophageal neoplasm (HP:0100751)1.92573312
145Neoplasm of head and neck (HP:0012288)1.92573312
146Fair hair (HP:0002286)1.88426111
147Hepatocellular carcinoma (HP:0001402)1.88145825
148Hypophosphatemic rickets (HP:0004912)1.87817558
149Acanthocytosis (HP:0001927)1.87727926
150Poor suck (HP:0002033)1.87636260
151Abnormality of sulfur amino acid metabolism (HP:0004339)1.87573270
152Dicarboxylic aciduria (HP:0003215)1.86167756
153Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86167756
154Scanning speech (HP:0002168)1.86021356
155Joint swelling (HP:0001386)1.85781894
156Optic disc pallor (HP:0000543)1.85635202
157Abnormality of purine metabolism (HP:0004352)1.85490748
158Nausea (HP:0002018)1.85309260
159Retinal dysplasia (HP:0007973)1.85196573
160Type II lissencephaly (HP:0007260)1.84729367
161Abnormality of transition element cation homeostasis (HP:0011030)1.82685323
162Acute hepatic failure (HP:0006554)1.82143962
163Respiratory failure (HP:0002878)1.80912156
164Abnormality of complement system (HP:0005339)1.80832169
165Craniofacial dystonia (HP:0012179)1.78718758
166Widely patent fontanelles and sutures (HP:0004492)1.78608950
167Abnormality of the lumbar spine (HP:0100712)1.78122301
168Peritonitis (HP:0002586)1.76671744
169Abnormal tarsal ossification (HP:0008369)1.76398904
170Gangrene (HP:0100758)1.74530427
171Pulmonary infiltrates (HP:0002113)1.74191706
172Gastrointestinal infarctions (HP:0005244)1.73238828
173Pathologic fracture (HP:0002756)1.69620625
174Malnutrition (HP:0004395)1.68644760
175Hypertriglyceridemia (HP:0002155)1.68363463
176Beaking of vertebral bodies (HP:0004568)1.68356845
177Arthropathy (HP:0003040)1.67525275
178Gingivitis (HP:0000230)1.63873262

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.78575159
2CASK4.20527579
3TGFBR24.07869316
4EPHA43.17540845
5FGFR43.13513129
6DDR23.12218697
7RIPK42.94556670
8BLK2.89720902
9MAP2K42.87028471
10TYK22.83176733
11FGFR32.77052272
12NTRK32.65457866
13MAP2K72.62863257
14ACVR1B2.50645053
15MAP3K42.41008430
16ERN12.37868386
17IRAK32.24550533
18CDK192.19932111
19PIK3CA2.17238567
20RIPK12.15620676
21OXSR12.13724453
22MUSK2.07697339
23ARAF1.89993188
24DAPK21.82230585
25BCKDK1.78015838
26MAP3K91.71764261
27PLK21.67697745
28DAPK11.64108283
29GRK51.61518949
30CSK1.59902903
31MAP3K141.58592067
32MATK1.57043053
33PDGFRA1.55876846
34CSF1R1.54731350
35BMPR21.53892323
36MINK11.52107406
37STK161.44915679
38NEK91.44212302
39KSR21.42401177
40MAPKAPK51.42397165
41ERBB41.41684722
42MAPKAPK31.40998372
43STK391.39611570
44MAP3K61.39160041
45JAK11.38684412
46PRKAA21.34102799
47AKT31.31985899
48FGR1.29586835
49PNCK1.29335899
50PDK21.29203616
51TBK11.27790423
52MAP3K31.27670749
53NME11.26439491
54ZAP701.25678780
55CAMK2A1.23809444
56MYLK1.23325814
57GRK71.20949465
58MAP3K21.19839377
59MAP3K131.14905904
60CAMK2B1.14424046
61GRK61.14266328
62CDC42BPA1.13997230
63TNIK1.12833983
64EPHA31.11582453
65FER1.06012524
66PTK2B1.04973155
67FES1.02417312
68NTRK11.01137594
69PRKCG1.00675724
70TYRO30.99812033
71KIT0.96491386
72SGK4940.95207621
73SGK2230.95207621
74JAK20.94872439
75RAF10.94059880
76ADRBK20.93476179
77CDK50.92768460
78LYN0.88839997
79TAOK30.87615338
80MAPK130.87611397
81FRK0.85825923
82BRAF0.84359821
83CAMKK20.83747142
84PRKCE0.82765429
85CAMK1D0.82052060
86CSNK1G20.81604277
87NTRK20.81219154
88PDGFRB0.80687253
89MAPK120.79378571
90IKBKB0.79061380
91SGK30.78877824
92CDK60.78801906
93CAMK2G0.78543452
94LMTK20.77303740
95IGF1R0.77048086
96ERBB20.75269121
97MARK10.75134064
98KSR10.74499592
99YES10.74247245
100PKN10.73747990
101JAK30.72879997
102SGK20.71824711
103CSNK1G30.70924557
104LATS10.69574703
105IKBKE0.69385221
106CAMK2D0.69205685
107PINK10.69102879
108MST40.67841553
109FGFR20.66671838
110ABL20.65064295
111NLK0.64918859
112MAP2K30.63572067
113ICK0.63194486
114MST1R0.62184463
115CSNK1G10.61681225
116PDPK10.61509535
117ABL10.60322862
118VRK10.59101206
119RET0.57964028
120PAK60.57319674
121MAP3K110.56828691
122TNK20.56066223
123PRKCQ0.55231776
124GSK3A0.54124251
125WNK40.53496099
126PDK40.52728826
127PDK30.52728826
128INSRR0.51642127
129CCNB10.51387376
130MAP3K10.50923425
131PRKACA0.50781711
132MAP2K10.50581919
133MAP2K60.49837504
134MAPK110.49833105
135PDK10.49824303
136LCK0.48545812
137NME20.47848140
138ADRBK10.47182825
139IRAK40.46963062
140SRC0.46733924
141BCR0.46117622
142SYK0.45750573
143PIK3CG0.44299065
144PRKG20.43363815
145SIK30.43285001
146STK38L0.42487687
147MAP3K50.41684399
148CAMKK10.41440585
149MOS0.41440247
150FGFR10.41272540
151DYRK1A0.40489229
152WNK30.39991261
153TSSK60.39307472
154SGK10.39108972
155IRAK10.38125820
156CAMK10.38084940
157CHUK0.37929885
158PRKCA0.37449124
159PRKG10.37192798
160PRKACG0.36498260
161FYN0.36184196
162CDK80.36098772
163HCK0.34952390
164INSR0.34631928
165ROCK20.34531068
166PIM20.34269473
167TIE10.34215685

Predicted pathways (KEGG)

RankGene SetZ-score
1Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.96253690
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.90737041
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.74827252
4Other glycan degradation_Homo sapiens_hsa005112.59770539
5Oxidative phosphorylation_Homo sapiens_hsa001902.17024933
6Nicotine addiction_Homo sapiens_hsa050332.14695551
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.13811099
8Nitrogen metabolism_Homo sapiens_hsa009102.12667500
9Fatty acid elongation_Homo sapiens_hsa000622.10857932
10Arginine biosynthesis_Homo sapiens_hsa002202.07211294
11Propanoate metabolism_Homo sapiens_hsa006401.94915955
12Lysosome_Homo sapiens_hsa041421.93502931
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91169482
14Collecting duct acid secretion_Homo sapiens_hsa049661.89012208
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88828979
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87720534
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.87368542
18Butanoate metabolism_Homo sapiens_hsa006501.85721097
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84663241
20Complement and coagulation cascades_Homo sapiens_hsa046101.69964160
21Pyruvate metabolism_Homo sapiens_hsa006201.67779217
22Fat digestion and absorption_Homo sapiens_hsa049751.64491883
23Pertussis_Homo sapiens_hsa051331.63857669
24Sulfur metabolism_Homo sapiens_hsa009201.61002325
25* Histidine metabolism_Homo sapiens_hsa003401.59781537
26Synaptic vesicle cycle_Homo sapiens_hsa047211.58341028
27Tryptophan metabolism_Homo sapiens_hsa003801.57693314
28Fatty acid degradation_Homo sapiens_hsa000711.57311648
29Peroxisome_Homo sapiens_hsa041461.56560622
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50396438
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49937565
32Parkinsons disease_Homo sapiens_hsa050121.49876522
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.47935737
34Fatty acid metabolism_Homo sapiens_hsa012121.45140379
35Alzheimers disease_Homo sapiens_hsa050101.42576432
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.41228618
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40092459
38GABAergic synapse_Homo sapiens_hsa047271.38247321
39Mineral absorption_Homo sapiens_hsa049781.29291958
40Phenylalanine metabolism_Homo sapiens_hsa003601.28409734
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26928092
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21121340
43Chemical carcinogenesis_Homo sapiens_hsa052041.20977122
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20736217
45beta-Alanine metabolism_Homo sapiens_hsa004101.19500963
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.16879867
47PPAR signaling pathway_Homo sapiens_hsa033201.16429652
48Tyrosine metabolism_Homo sapiens_hsa003501.14150537
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.13379590
50Asthma_Homo sapiens_hsa053101.13027217
51Steroid biosynthesis_Homo sapiens_hsa001001.10520199
52Glutamatergic synapse_Homo sapiens_hsa047241.08335949
53Morphine addiction_Homo sapiens_hsa050321.07667239
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07374293
55Amphetamine addiction_Homo sapiens_hsa050311.06398316
56Caffeine metabolism_Homo sapiens_hsa002321.05469103
57Leishmaniasis_Homo sapiens_hsa051401.03582869
58Renin-angiotensin system_Homo sapiens_hsa046141.02455397
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97456353
60Long-term potentiation_Homo sapiens_hsa047200.97027875
61Bile secretion_Homo sapiens_hsa049760.96267194
62Salivary secretion_Homo sapiens_hsa049700.96231181
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96187821
64Circadian entrainment_Homo sapiens_hsa047130.95311485
65Staphylococcus aureus infection_Homo sapiens_hsa051500.93152762
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.91136818
67Vitamin digestion and absorption_Homo sapiens_hsa049770.90323387
68Serotonergic synapse_Homo sapiens_hsa047260.89933133
69Osteoclast differentiation_Homo sapiens_hsa043800.89827565
70Carbon metabolism_Homo sapiens_hsa012000.88975742
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88880985
72Taste transduction_Homo sapiens_hsa047420.88810006
73Renin secretion_Homo sapiens_hsa049240.87930797
74Malaria_Homo sapiens_hsa051440.83369510
75Tuberculosis_Homo sapiens_hsa051520.83131020
76Vibrio cholerae infection_Homo sapiens_hsa051100.82903765
77Olfactory transduction_Homo sapiens_hsa047400.82891303
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81325089
79Starch and sucrose metabolism_Homo sapiens_hsa005000.80130154
80Dopaminergic synapse_Homo sapiens_hsa047280.79770207
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78820065
82Allograft rejection_Homo sapiens_hsa053300.78769166
83Arachidonic acid metabolism_Homo sapiens_hsa005900.76649179
84Retinol metabolism_Homo sapiens_hsa008300.76556104
85Huntingtons disease_Homo sapiens_hsa050160.76530205
86Vitamin B6 metabolism_Homo sapiens_hsa007500.75978825
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74420804
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74006739
89Long-term depression_Homo sapiens_hsa047300.73727782
90Graft-versus-host disease_Homo sapiens_hsa053320.71131719
91Folate biosynthesis_Homo sapiens_hsa007900.70266271
92Calcium signaling pathway_Homo sapiens_hsa040200.69324977
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68820627
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.65048341
95Cocaine addiction_Homo sapiens_hsa050300.64377444
96Sulfur relay system_Homo sapiens_hsa041220.63438757
97Linoleic acid metabolism_Homo sapiens_hsa005910.63240492
98Biosynthesis of amino acids_Homo sapiens_hsa012300.62591852
99Glycerolipid metabolism_Homo sapiens_hsa005610.62119947
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.60440680
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.59967706
102Sphingolipid metabolism_Homo sapiens_hsa006000.58689830
103Autoimmune thyroid disease_Homo sapiens_hsa053200.58608868
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58579962
105Arginine and proline metabolism_Homo sapiens_hsa003300.57535560
106Glutathione metabolism_Homo sapiens_hsa004800.56991951
107ABC transporters_Homo sapiens_hsa020100.55904591
108Cardiac muscle contraction_Homo sapiens_hsa042600.55680579
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.54485003
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54304014
111Metabolic pathways_Homo sapiens_hsa011000.52677592
112Legionellosis_Homo sapiens_hsa051340.52076999
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50946400
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49350577
115Insulin secretion_Homo sapiens_hsa049110.49329790
116Type I diabetes mellitus_Homo sapiens_hsa049400.49108885
117Galactose metabolism_Homo sapiens_hsa000520.48899798
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48633876
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48522638
120Antigen processing and presentation_Homo sapiens_hsa046120.48074046
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48066155
122Rheumatoid arthritis_Homo sapiens_hsa053230.47330491
123Gastric acid secretion_Homo sapiens_hsa049710.46491787
124Fatty acid biosynthesis_Homo sapiens_hsa000610.46306380
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44398498
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43733966
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43716508
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43362085
129Hematopoietic cell lineage_Homo sapiens_hsa046400.43285435
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42323807
131Phagosome_Homo sapiens_hsa041450.42299876
132TNF signaling pathway_Homo sapiens_hsa046680.42029300
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.39503738
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38823971
135Toxoplasmosis_Homo sapiens_hsa051450.38559932
136African trypanosomiasis_Homo sapiens_hsa051430.38255865
137Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37523674
138Prion diseases_Homo sapiens_hsa050200.37403496
139Fructose and mannose metabolism_Homo sapiens_hsa000510.35946162
140Amoebiasis_Homo sapiens_hsa051460.34436741
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33897277
142Salmonella infection_Homo sapiens_hsa051320.31238821
143Insulin resistance_Homo sapiens_hsa049310.31034785
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28366594
145Ether lipid metabolism_Homo sapiens_hsa005650.28144051

Most similar genes based on co-expression Upload to Enrichr

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