ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	4.07344027
2	protein deneddylation (GO:0000338)	4.04412595
3	cullin deneddylation (GO:0010388)	4.03464178
4	histone H2A acetylation (GO:0043968)	3.82486340
5	DNA double-strand break processing (GO:0000729)	3.78089248
6	proteasome assembly (GO:0043248)	3.60641490
7	rRNA modification (GO:0000154)	3.38857881
8	regulation of DNA endoreduplication (GO:0032875)	3.37502696
9	kinetochore assembly (GO:0051382)	3.37100628
10	neural tube formation (GO:0001841)	3.36976516
11	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.36501930
12	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.35879424
13	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.35879424
14	isotype switching (GO:0045190)	3.35879424
15	inositol phosphate catabolic process (GO:0071545)	3.34197267
16	double-strand break repair via nonhomologous end joining (GO:0006303)	3.31453205
17	non-recombinational repair (GO:0000726)	3.31453205
18	base-excision repair, AP site formation (GO:0006285)	3.30836666
19	rRNA methylation (GO:0031167)	3.30629725
20	DNA ligation (GO:0006266)	3.29577525
21	DNA damage response, detection of DNA damage (GO:0042769)	3.28918375
22	replication fork processing (GO:0031297)	3.26716690
23	centriole replication (GO:0007099)	3.26551478
24	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.25886104
25	synapsis (GO:0007129)	3.19541449
26	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.18862542
27	regulation of mitotic spindle checkpoint (GO:1903504)	3.18862542
28	resolution of meiotic recombination intermediates (GO:0000712)	3.16711774
29	DNA methylation involved in gamete generation (GO:0043046)	3.12433169
30	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.08240745
31	kinetochore organization (GO:0051383)	3.07063261
32	peptidyl-histidine modification (GO:0018202)	3.06016448
33	chromatin remodeling at centromere (GO:0031055)	3.03104468
34	protein K6-linked ubiquitination (GO:0085020)	3.00201961
35	DNA catabolic process, exonucleolytic (GO:0000738)	3.00049674
36	CENP-A containing nucleosome assembly (GO:0034080)	2.96089982
37	DNA deamination (GO:0045006)	2.94855332
38	male meiosis (GO:0007140)	2.94276521
39	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.94234830
40	positive regulation of mitochondrial fission (GO:0090141)	2.90985792
41	transcription from mitochondrial promoter (GO:0006390)	2.89424452
42	recombinational repair (GO:0000725)	2.88672854
43	spliceosomal snRNP assembly (GO:0000387)	2.88645836
44	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.88468162
45	DNA integration (GO:0015074)	2.88273451
46	double-strand break repair via homologous recombination (GO:0000724)	2.84250398
47	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.83462742
48	inositol phosphate dephosphorylation (GO:0046855)	2.83462742
49	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.82968925
50	rRNA catabolic process (GO:0016075)	2.81908511
51	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.81563950
52	somatic diversification of immune receptors via germline recombination within a single locus (GO:000	2.74870320
53	somatic cell DNA recombination (GO:0016444)	2.74870320
54	attachment of spindle microtubules to kinetochore (GO:0008608)	2.73317370
55	somatic diversification of immune receptors (GO:0002200)	2.72852412
56	histone exchange (GO:0043486)	2.71916128
57	response to pheromone (GO:0019236)	2.71731113
58	intraciliary transport (GO:0042073)	2.69405031
59	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.69213325
60	protein-cofactor linkage (GO:0018065)	2.66926947
61	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.66320602
62	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.66320602
63	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.65131925
64	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.65131925
65	secondary metabolite biosynthetic process (GO:0044550)	2.64785355
66	protein K11-linked deubiquitination (GO:0035871)	2.62589034
67	positive regulation of histone H3-K4 methylation (GO:0051571)	2.61279835
68	adenosine metabolic process (GO:0046085)	2.60308152
69	fucose catabolic process (GO:0019317)	2.59013501
70	L-fucose metabolic process (GO:0042354)	2.59013501
71	L-fucose catabolic process (GO:0042355)	2.59013501
72	protein polyglutamylation (GO:0018095)	2.56953544
73	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.56492224
74	histone mRNA metabolic process (GO:0008334)	2.56443001
75	somite development (GO:0061053)	2.56037015
76	somatic diversification of immunoglobulins (GO:0016445)	2.55818747
77	negative regulation of mRNA processing (GO:0050686)	2.55662661
78	positive regulation of granulocyte differentiation (GO:0030854)	2.53054976
79	polyol catabolic process (GO:0046174)	2.53006705
80	V(D)J recombination (GO:0033151)	2.49500033
81	cornea development in camera-type eye (GO:0061303)	2.48946186
82	mitochondrial RNA metabolic process (GO:0000959)	2.48872259
83	double-strand break repair (GO:0006302)	2.48384833
84	mitotic spindle checkpoint (GO:0071174)	2.48153489
85	respiratory chain complex IV assembly (GO:0008535)	2.48085394
86	DNA recombination (GO:0006310)	2.47936500
87	termination of RNA polymerase III transcription (GO:0006386)	2.47229037
88	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.47229037
89	ncRNA catabolic process (GO:0034661)	2.45850719
90	cell wall macromolecule catabolic process (GO:0016998)	2.45821553
91	spindle checkpoint (GO:0031577)	2.45532056
92	melanin biosynthetic process (GO:0042438)	2.45232780
93	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.44846124
94	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.44759826
95	melanin metabolic process (GO:0006582)	2.44689095
96	regulation of mRNA splicing, via spliceosome (GO:0048024)	2.43996392
97	histone mRNA catabolic process (GO:0071044)	2.42881432
98	L-methionine salvage (GO:0071267)	2.40627658
99	L-methionine biosynthetic process (GO:0071265)	2.40627658
100	amino acid salvage (GO:0043102)	2.40627658

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.08437653
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.67055281
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.30522441
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.27412750
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.99575815
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.87066471
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.85147937
8	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.82325590
9	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.77203446
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.69957412
11	* VDR_23849224_ChIP-Seq_CD4+_Human	2.62706854
12	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.57760128
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.55596920
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.52936423
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.36154862
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.34809048
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.33911275
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.21196131
19	E2F7_22180533_ChIP-Seq_HELA_Human	2.19988390
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.18840228
21	* FOXP3_21729870_ChIP-Seq_TREG_Human	2.16975150
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.15564807
23	FUS_26573619_Chip-Seq_HEK293_Human	2.08326723
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.05867927
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04477297
26	EWS_26573619_Chip-Seq_HEK293_Human	1.95624025
27	GBX2_23144817_ChIP-Seq_PC3_Human	1.95427818
28	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.94109992
29	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.90703164
30	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.86186864
31	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.83535833
32	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.82815694
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.81319495
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.81252818
35	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.69160233
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.67085575
37	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.62416095
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59729169
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.55396840
40	TAF15_26573619_Chip-Seq_HEK293_Human	1.55334409
41	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.54907689
42	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.54505140
43	VDR_22108803_ChIP-Seq_LS180_Human	1.54328556
44	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.54099877
45	GABP_19822575_ChIP-Seq_HepG2_Human	1.53807171
46	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.52782340
47	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.46508771
48	P300_19829295_ChIP-Seq_ESCs_Human	1.46459457
49	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.45913476
50	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.45374751
51	CIITA_25753668_ChIP-Seq_RAJI_Human	1.36592447
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.35380426
53	DCP1A_22483619_ChIP-Seq_HELA_Human	1.33190222
54	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33179085
55	TTF2_22483619_ChIP-Seq_HELA_Human	1.32473184
56	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.29550321
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27728378
58	CBP_20019798_ChIP-Seq_JUKART_Human	1.26992432
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26992432
60	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.22378298
61	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.19144697
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.17210048
63	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.12171720
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11094351
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10899972
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09615056
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07870853
68	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.07765947
69	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.06452146
70	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06212688
71	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.05741031
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03259155
73	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.02229252
74	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.01578237
75	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00435077
76	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.00262936
77	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.99542037
78	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.99095138
79	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.98543963
80	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.94455351
81	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.93682923
82	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.93025047
83	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.92354827
84	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.92146100
85	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.92141550
86	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.91930649
87	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.91775159
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.91213024
89	SMAD4_21799915_ChIP-Seq_A2780_Human	0.90953528
90	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.90118223
91	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.90006386
92	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.89062860
93	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.88843296
94	BCAT_22108803_ChIP-Seq_LS180_Human	0.88348311
95	KDM5A_27292631_Chip-Seq_BREAST_Human	0.87115307
96	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.86756741
97	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.84849592
98	* GATA3_26560356_Chip-Seq_TH2_Human	0.84627662
99	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.84386284
100	TCF4_22108803_ChIP-Seq_LS180_Human	0.83636324

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.67960039
2	MP0000372_irregular_coat_pigmentation	4.49251106
3	MP0008058_abnormal_DNA_repair	3.73718932
4	MP0010094_abnormal_chromosome_stability	3.49668940
5	MP0008877_abnormal_DNA_methylation	3.37777016
6	MP0005075_abnormal_melanosome_morpholog	2.77756072
7	MP0006292_abnormal_olfactory_placode	2.54450469
8	MP0006072_abnormal_retinal_apoptosis	2.52777053
9	MP0003693_abnormal_embryo_hatching	2.45975798
10	MP0008789_abnormal_olfactory_epithelium	2.02426462
11	MP0008057_abnormal_DNA_replication	2.02120111
12	MP0003718_maternal_effect	1.86717696
13	MP0003111_abnormal_nucleus_morphology	1.83567587
14	MP0000569_abnormal_digit_pigmentation	1.82484234
15	MP0001529_abnormal_vocalization	1.77372190
16	MP0003880_abnormal_central_pattern	1.76136696
17	MP0005253_abnormal_eye_physiology	1.74859798
18	MP0002095_abnormal_skin_pigmentation	1.70552762
19	MP0002751_abnormal_autonomic_nervous	1.69625371
20	MP0005645_abnormal_hypothalamus_physiol	1.65823995
21	MP0005394_taste/olfaction_phenotype	1.61620897
22	MP0005499_abnormal_olfactory_system	1.61620897
23	MP0003077_abnormal_cell_cycle	1.60440260
24	MP0005367_renal/urinary_system_phenotyp	1.58873286
25	MP0000516_abnormal_urinary_system	1.58873286
26	MP0002938_white_spotting	1.55949175
27	MP0005408_hypopigmentation	1.49503438
28	MP0003786_premature_aging	1.47509184
29	MP0004957_abnormal_blastocyst_morpholog	1.46966589
30	MP0000015_abnormal_ear_pigmentation	1.46921331
31	MP0008995_early_reproductive_senescence	1.41814355
32	MP0002234_abnormal_pharynx_morphology	1.41391346
33	MP0003787_abnormal_imprinting	1.38937388
34	MP0002736_abnormal_nociception_after	1.37072128
35	MP0005551_abnormal_eye_electrophysiolog	1.31399767
36	MP0004142_abnormal_muscle_tone	1.29217887
37	MP0006276_abnormal_autonomic_nervous	1.26927818
38	MP0003136_yellow_coat_color	1.20584175
39	MP0002163_abnormal_gland_morphology	1.20104680
40	MP0001929_abnormal_gametogenesis	1.19372850
41	MP0001986_abnormal_taste_sensitivity	1.18911680
42	MP0000465_gastrointestinal_hemorrhage	1.18551072
43	MP0002638_abnormal_pupillary_reflex	1.18302217
44	MP0005174_abnormal_tail_pigmentation	1.17144971
45	MP0003763_abnormal_thymus_physiology	1.14496426
46	MP0003121_genomic_imprinting	1.14314944
47	MP0009697_abnormal_copulation	1.14253500
48	MP0003195_calcinosis	1.14201076
49	MP0008007_abnormal_cellular_replicative	1.13707156
50	MP0005646_abnormal_pituitary_gland	1.12954756
51	MP0008932_abnormal_embryonic_tissue	1.12562549
52	MP0002210_abnormal_sex_determination	1.12069902
53	MP0001324_abnormal_eye_pigmentation	1.11170534
54	MP0008872_abnormal_physiological_respon	1.09563402
55	MP0002822_catalepsy	1.09416635
56	MP0001984_abnormal_olfaction	1.09183357
57	MP0006036_abnormal_mitochondrial_physio	1.08398162
58	MP0001968_abnormal_touch/_nociception	1.02550493
59	MP0000653_abnormal_sex_gland	0.98834233
60	MP0001293_anophthalmia	0.98236906
61	MP0001119_abnormal_female_reproductive	0.96904325
62	MP0003698_abnormal_male_reproductive	0.96558056
63	MP0001145_abnormal_male_reproductive	0.96413076
64	MP0005391_vision/eye_phenotype	0.91098676
65	MP0005379_endocrine/exocrine_gland_phen	0.87811836
66	MP0006035_abnormal_mitochondrial_morpho	0.84853300
67	MP0004885_abnormal_endolymph	0.84836582
68	MP0001919_abnormal_reproductive_system	0.84332544
69	MP0002396_abnormal_hematopoietic_system	0.83716131
70	MP0003890_abnormal_embryonic-extraembry	0.83629233
71	MP0005389_reproductive_system_phenotype	0.83544997
72	MP0002233_abnormal_nose_morphology	0.83329218
73	MP0000703_abnormal_thymus_morphology	0.80962359
74	MP0000631_abnormal_neuroendocrine_gland	0.80619504
75	MP0000049_abnormal_middle_ear	0.80320394
76	MP0001486_abnormal_startle_reflex	0.80214151
77	MP0000371_diluted_coat_color	0.80005922
78	MP0003567_abnormal_fetal_cardiomyocyte	0.79599217
79	MP0003011_delayed_dark_adaptation	0.79076822
80	MP0003221_abnormal_cardiomyocyte_apopto	0.75177433
81	MP0002184_abnormal_innervation	0.74930398
82	MP0004381_abnormal_hair_follicle	0.74753870
83	MP0003186_abnormal_redox_activity	0.73454969
84	MP0001485_abnormal_pinna_reflex	0.73448663
85	MP0001835_abnormal_antigen_presentation	0.71019033
86	MP0001764_abnormal_homeostasis	0.70907667
87	MP0000689_abnormal_spleen_morphology	0.68209368
88	MP0005671_abnormal_response_to	0.67749180
89	MP0000427_abnormal_hair_cycle	0.67073238
90	MP0002752_abnormal_somatic_nervous	0.65696963
91	MP0001905_abnormal_dopamine_level	0.65589959
92	MP0002272_abnormal_nervous_system	0.64849020
93	MP0000778_abnormal_nervous_system	0.64796631
94	MP0000358_abnormal_cell_content/	0.64436800
95	MP0003943_abnormal_hepatobiliary_system	0.64097565
96	MP0002019_abnormal_tumor_incidence	0.63198689
97	MP0002090_abnormal_vision	0.62933586
98	MP0004742_abnormal_vestibular_system	0.62005117
99	MP0009745_abnormal_behavioral_response	0.61581071
100	MP0005195_abnormal_posterior_eye	0.60721051

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe combined immunodeficiency (HP:0004430)	3.69964730
2	Abnormality of the labia minora (HP:0012880)	3.69852884
3	Volvulus (HP:0002580)	3.16153111
4	Thyroiditis (HP:0100646)	3.14850730
5	Combined immunodeficiency (HP:0005387)	3.09693722
6	Intestinal atresia (HP:0011100)	3.07736138
7	B lymphocytopenia (HP:0010976)	3.05078364
8	True hermaphroditism (HP:0010459)	3.03875291
9	Abnormality of midbrain morphology (HP:0002418)	2.83101031
10	Molar tooth sign on MRI (HP:0002419)	2.83101031
11	Abnormality of B cell number (HP:0010975)	2.77711351
12	Panhypogammaglobulinemia (HP:0003139)	2.75577307
13	Pancreatic cysts (HP:0001737)	2.68820400
14	Medial flaring of the eyebrow (HP:0010747)	2.61031424
15	Abnormality of chromosome stability (HP:0003220)	2.60949648
16	Nephrogenic diabetes insipidus (HP:0009806)	2.57551733
17	Chromsome breakage (HP:0040012)	2.55813052
18	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.55612471
19	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.53679215
20	IgG deficiency (HP:0004315)	2.53579859
21	Colon cancer (HP:0003003)	2.53428134
22	Methylmalonic acidemia (HP:0002912)	2.45314629
23	Congenital primary aphakia (HP:0007707)	2.43972884
24	Pancreatic fibrosis (HP:0100732)	2.42522900
25	Sloping forehead (HP:0000340)	2.40776097
26	Ependymoma (HP:0002888)	2.35584177
27	Nephronophthisis (HP:0000090)	2.35523280
28	Renal cortical cysts (HP:0000803)	2.34459573
29	Gait imbalance (HP:0002141)	2.33290087
30	Abnormality of the ileum (HP:0001549)	2.30506297
31	Meckel diverticulum (HP:0002245)	2.25816646
32	Abnormality of eosinophils (HP:0001879)	2.21252149
33	Increased hepatocellular lipid droplets (HP:0006565)	2.17619907
34	Increased CSF lactate (HP:0002490)	2.11660368
35	Abnormal lung lobation (HP:0002101)	2.10356822
36	Duodenal stenosis (HP:0100867)	2.09113595
37	Small intestinal stenosis (HP:0012848)	2.09113595
38	Pendular nystagmus (HP:0012043)	2.06840550
39	Mitochondrial inheritance (HP:0001427)	2.05006159
40	Abnormality of the preputium (HP:0100587)	2.04327590
41	Median cleft lip (HP:0000161)	2.02345937
42	Abnormal protein N-linked glycosylation (HP:0012347)	2.01364225
43	Abnormal protein glycosylation (HP:0012346)	2.01364225
44	Abnormal glycosylation (HP:0012345)	2.01364225
45	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.01364225
46	Hepatocellular necrosis (HP:0001404)	2.00104029
47	Hyperglycinemia (HP:0002154)	1.99958522
48	Abnormality of the renal medulla (HP:0100957)	1.98822626
49	Bifid tongue (HP:0010297)	1.98346296
50	Abnormality of the astrocytes (HP:0100707)	1.98007651
51	Astrocytoma (HP:0009592)	1.98007651
52	Lipid accumulation in hepatocytes (HP:0006561)	1.96817269
53	Abnormality of the renal cortex (HP:0011035)	1.95751838
54	Hypoplasia of the thymus (HP:0000778)	1.94655795
55	Astigmatism (HP:0000483)	1.93389198
56	Abnormality of macular pigmentation (HP:0008002)	1.91407668
57	Tubulointerstitial nephritis (HP:0001970)	1.90662904
58	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.89666512
59	Short 1st metacarpal (HP:0010034)	1.89666512
60	Long clavicles (HP:0000890)	1.88851036
61	Methylmalonic aciduria (HP:0012120)	1.88264921
62	Abnormality of the duodenum (HP:0002246)	1.87888073
63	Myelodysplasia (HP:0002863)	1.87461554
64	Abolished electroretinogram (ERG) (HP:0000550)	1.87331957
65	Acute necrotizing encephalopathy (HP:0006965)	1.84972520
66	Glioma (HP:0009733)	1.84468658
67	Postaxial foot polydactyly (HP:0001830)	1.83793211
68	Retinal dysplasia (HP:0007973)	1.82412060
69	Stomatitis (HP:0010280)	1.81932227
70	Abnormality of the fovea (HP:0000493)	1.80068341
71	Congenital stationary night blindness (HP:0007642)	1.79272301
72	3-Methylglutaconic aciduria (HP:0003535)	1.79160857
73	Failure to thrive in infancy (HP:0001531)	1.77955147
74	Narrow forehead (HP:0000341)	1.77016305
75	Progressive inability to walk (HP:0002505)	1.76265082
76	Aplasia/Hypoplasia of the macula (HP:0008059)	1.75013946
77	Clubbing of toes (HP:0100760)	1.74456065
78	Gaze-evoked nystagmus (HP:0000640)	1.74263398
79	Broad foot (HP:0001769)	1.73705427
80	Abnormality of the metopic suture (HP:0005556)	1.73677819
81	Hypoplasia of the fovea (HP:0007750)	1.72842797
82	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.72842797
83	Postaxial hand polydactyly (HP:0001162)	1.72414137
84	Hepatic necrosis (HP:0002605)	1.71406155
85	Increased serum lactate (HP:0002151)	1.71152243
86	Small hand (HP:0200055)	1.71054716
87	Hypoproteinemia (HP:0003075)	1.70399517
88	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.70115323
89	Increased intramyocellular lipid droplets (HP:0012240)	1.69132482
90	Adactyly (HP:0009776)	1.68494480
91	Albinism (HP:0001022)	1.66976853
92	Supernumerary spleens (HP:0009799)	1.66683636
93	Progressive microcephaly (HP:0000253)	1.66313809
94	Poor coordination (HP:0002370)	1.66278559
95	Genital tract atresia (HP:0001827)	1.65612469
96	Abnormal rod and cone electroretinograms (HP:0008323)	1.64788908
97	Oligodactyly (hands) (HP:0001180)	1.64699244
98	Eosinophilia (HP:0001880)	1.63755379
99	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.63544997
100	Patellar aplasia (HP:0006443)	1.63229175

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	5.45407133
2	TRIM28	3.75835846
3	EIF2AK3	2.72424698
4	TAOK3	2.46859831
5	NUAK1	2.26292696
6	FRK	2.23922945
7	EIF2AK1	2.20228314
8	SRPK1	2.10338399
9	BCR	2.02053837
10	TXK	2.01879115
11	BMPR1B	1.95860467
12	ZAK	1.87119629
13	MAP3K4	1.76738068
14	MKNK1	1.71521373
15	MKNK2	1.71314661
16	PLK3	1.70678537
17	ERBB3	1.69926334
18	WNK3	1.62288494
19	MAPK13	1.59776228
20	NEK1	1.57836551
21	SIK3	1.51584265
22	BUB1	1.47987847
23	PINK1	1.46777602
24	PLK2	1.46773283
25	MST4	1.37692381
26	PASK	1.34599351
27	WEE1	1.33601270
28	VRK2	1.31135309
29	MAP2K7	1.29852968
30	BCKDK	1.27834197
31	VRK1	1.24687108
32	BRD4	1.20186797
33	ATR	1.19496854
34	RPS6KA4	1.19485164
35	TAF1	1.14683692
36	FLT3	1.13544449
37	TSSK6	1.12299933
38	PLK4	1.11885093
39	NLK	1.10470980
40	GRK6	1.09931593
41	MARK3	1.08290734
42	EIF2AK2	1.00461245
43	CSNK1G1	0.98490890
44	BRSK2	0.97783607
45	PLK1	0.97435559
46	CCNB1	0.91184693
47	CSNK1G3	0.90916670
48	STK38L	0.90404598
49	TGFBR1	0.89116815
50	CDC7	0.85581609
51	DYRK2	0.83776015
52	DYRK1A	0.81999882
53	PAK3	0.79414119
54	DYRK3	0.78998317
55	STK16	0.76428430
56	CSNK1A1L	0.75023234
57	EPHA4	0.74808934
58	ATM	0.74524789
59	CAMKK2	0.73639265
60	TNK2	0.73004465
61	CDK3	0.72262122
62	ACVR1B	0.66505052
63	TTK	0.66307803
64	TEC	0.65842145
65	TNIK	0.65394579
66	CSNK1G2	0.65385360
67	EPHA3	0.63311434
68	ADRBK2	0.63252697
69	OXSR1	0.60343656
70	MAP4K1	0.59502473
71	GRK1	0.57787335
72	PBK	0.57360972
73	MINK1	0.55133598
74	SIK2	0.54071416
75	CHEK1	0.53029915
76	WNK4	0.52900136
77	AURKB	0.52189523
78	PTK2B	0.51753089
79	BMPR2	0.50640919
80	GRK5	0.48504283
81	CASK	0.45143154
82	STK39	0.43965189
83	PRKCE	0.41615143
84	TIE1	0.41111568
85	CDK8	0.37969340
86	PIM1	0.37243106
87	PRKCQ	0.36532797
88	KIT	0.36271081
89	CLK1	0.35524310
90	CDK19	0.34835952
91	CSNK1D	0.34272796
92	CHEK2	0.33260319
93	ADRBK1	0.32611614
94	CSNK2A1	0.31642272
95	RPS6KA5	0.31640730
96	CSNK1A1	0.30777663
97	NME1	0.30498310
98	KSR1	0.30304453
99	CSNK2A2	0.30025310
100	NTRK2	0.28410395

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	4.41788416
2	Protein export_Homo sapiens_hsa03060	3.18411195
3	Basal transcription factors_Homo sapiens_hsa03022	2.92041421
4	Proteasome_Homo sapiens_hsa03050	2.90191816
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.84779072
6	Homologous recombination_Homo sapiens_hsa03440	2.74979738
7	RNA polymerase_Homo sapiens_hsa03020	2.72455388
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.66457555
9	Mismatch repair_Homo sapiens_hsa03430	2.61609789
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.56935589
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.55321410
12	RNA degradation_Homo sapiens_hsa03018	2.39385019
13	* Spliceosome_Homo sapiens_hsa03040	2.39174337
14	Base excision repair_Homo sapiens_hsa03410	2.33309890
15	DNA replication_Homo sapiens_hsa03030	2.28011679
16	RNA transport_Homo sapiens_hsa03013	2.21318733
17	Propanoate metabolism_Homo sapiens_hsa00640	2.14273839
18	Nucleotide excision repair_Homo sapiens_hsa03420	2.00035842
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.86796307
20	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.85573063
21	Primary immunodeficiency_Homo sapiens_hsa05340	1.75361911
22	Regulation of autophagy_Homo sapiens_hsa04140	1.71054334
23	Butanoate metabolism_Homo sapiens_hsa00650	1.55571004
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.51566073
25	Phototransduction_Homo sapiens_hsa04744	1.51453479
26	Parkinsons disease_Homo sapiens_hsa05012	1.47311860
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.44964149
28	Cell cycle_Homo sapiens_hsa04110	1.28111652
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.27168243
30	Oocyte meiosis_Homo sapiens_hsa04114	1.26976426
31	Fatty acid elongation_Homo sapiens_hsa00062	1.26430342
32	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.26010387
33	Oxidative phosphorylation_Homo sapiens_hsa00190	1.25346777
34	Purine metabolism_Homo sapiens_hsa00230	1.25028060
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.23564773
36	mRNA surveillance pathway_Homo sapiens_hsa03015	1.21849822
37	Circadian rhythm_Homo sapiens_hsa04710	1.21770850
38	Caffeine metabolism_Homo sapiens_hsa00232	1.18803761
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.08912346
40	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.08084461
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.06136349
42	Huntingtons disease_Homo sapiens_hsa05016	1.02627745
43	Steroid biosynthesis_Homo sapiens_hsa00100	0.99164318
44	p53 signaling pathway_Homo sapiens_hsa04115	0.95872082
45	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.91832249
46	One carbon pool by folate_Homo sapiens_hsa00670	0.87204012
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.86671625
48	Peroxisome_Homo sapiens_hsa04146	0.85780754
49	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.84196174
50	Taste transduction_Homo sapiens_hsa04742	0.81457942
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75146077
52	Ribosome_Homo sapiens_hsa03010	0.72729502
53	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.71107458
54	Selenocompound metabolism_Homo sapiens_hsa00450	0.69959359
55	Allograft rejection_Homo sapiens_hsa05330	0.68376874
56	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.62783338
57	Asthma_Homo sapiens_hsa05310	0.60111544
58	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.59827097
59	Sulfur metabolism_Homo sapiens_hsa00920	0.58919616
60	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53315951
61	Olfactory transduction_Homo sapiens_hsa04740	0.53151140
62	Type I diabetes mellitus_Homo sapiens_hsa04940	0.52429123
63	Herpes simplex infection_Homo sapiens_hsa05168	0.50271139
64	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49505565
65	Metabolic pathways_Homo sapiens_hsa01100	0.48498528
66	Linoleic acid metabolism_Homo sapiens_hsa00591	0.46859648
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.44337059
68	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.41839803
69	Alzheimers disease_Homo sapiens_hsa05010	0.41284364
70	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.40050387
71	Nicotine addiction_Homo sapiens_hsa05033	0.39746720
72	Nitrogen metabolism_Homo sapiens_hsa00910	0.38423250
73	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.35017399
74	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.33688898
75	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.30836596
76	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.30829867
77	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.30285123
78	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.29691545
79	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.29337703
80	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.29149833
81	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.28107674
82	Ether lipid metabolism_Homo sapiens_hsa00565	0.28074183
83	Fatty acid metabolism_Homo sapiens_hsa01212	0.26254912
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.25920388
85	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.25728482
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.24386011
87	Graft-versus-host disease_Homo sapiens_hsa05332	0.23470820
88	GABAergic synapse_Homo sapiens_hsa04727	0.22364865
89	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.22353056
90	Carbon metabolism_Homo sapiens_hsa01200	0.20141210
91	Tryptophan metabolism_Homo sapiens_hsa00380	0.19369143
92	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.18375572
93	Wnt signaling pathway_Homo sapiens_hsa04310	0.18197388
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.17874658
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.17786849
96	Amphetamine addiction_Homo sapiens_hsa05031	0.17582633
97	Colorectal cancer_Homo sapiens_hsa05210	0.16941674
98	Measles_Homo sapiens_hsa05162	0.15459847
99	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.14745926
100	Folate biosynthesis_Homo sapiens_hsa00790	0.13970908

HNRNPA1L2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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