HNRNPA1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)6.58699191
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.57284899
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.08618421
4ATP synthesis coupled proton transport (GO:0015986)6.08618421
5DNA deamination (GO:0045006)5.23135197
6chaperone-mediated protein transport (GO:0072321)5.22760909
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.94970161
8proteasome assembly (GO:0043248)4.86594400
9maturation of SSU-rRNA (GO:0030490)4.22374259
10tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.10825039
11RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.10825039
12pseudouridine synthesis (GO:0001522)4.10385505
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.96883797
14regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.90474930
15purine nucleoside triphosphate biosynthetic process (GO:0009145)3.85615588
16ATP biosynthetic process (GO:0006754)3.83648489
17purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.81191181
18negative regulation of calcium ion transport into cytosol (GO:0010523)3.76482195
19respiratory electron transport chain (GO:0022904)3.75738046
20water-soluble vitamin biosynthetic process (GO:0042364)3.74556200
21GTP biosynthetic process (GO:0006183)3.73409705
22electron transport chain (GO:0022900)3.73408292
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.64881909
24protein neddylation (GO:0045116)3.63053902
25positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.54892008
26positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.53768368
27platelet dense granule organization (GO:0060155)3.49542706
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.45902531
29NADH dehydrogenase complex assembly (GO:0010257)3.45902531
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.45902531
31protein complex biogenesis (GO:0070271)3.39129148
32exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33534866
33ribonucleoside triphosphate biosynthetic process (GO:0009201)3.33044863
34UTP biosynthetic process (GO:0006228)3.31586274
35negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.31492806
36negative regulation of ligase activity (GO:0051352)3.31492806
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.31390112
38ribosome assembly (GO:0042255)3.28577879
39positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.27664723
40UTP metabolic process (GO:0046051)3.25406238
41mitochondrial respiratory chain complex assembly (GO:0033108)3.23104678
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21588444
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.21095181
44ribosomal large subunit biogenesis (GO:0042273)3.20607337
45regulation of cellular amino acid metabolic process (GO:0006521)3.20003325
46rRNA modification (GO:0000154)3.19142282
47regulation of hypersensitivity (GO:0002883)3.16901824
48positive regulation of natural killer cell mediated immunity (GO:0002717)3.15939597
49purine nucleoside monophosphate biosynthetic process (GO:0009127)3.08984814
50purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.08984814
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.05661723
52protein peptidyl-prolyl isomerization (GO:0000413)3.05631425
53signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05316542
54signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05316542
55signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05316542
56tRNA processing (GO:0008033)3.01118267
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.00734573
58intracellular protein transmembrane import (GO:0044743)2.99852183
59mannosylation (GO:0097502)2.99848571
60piRNA metabolic process (GO:0034587)2.97671687
61signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.96413923
62intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.96413923
63signal transduction involved in cell cycle checkpoint (GO:0072395)2.96115745
64protein-cofactor linkage (GO:0018065)2.94968366
65protein deneddylation (GO:0000338)2.93401968
66signal transduction involved in DNA integrity checkpoint (GO:0072401)2.92867201
67signal transduction involved in DNA damage checkpoint (GO:0072422)2.92867201
68prenylation (GO:0097354)2.92458828
69protein prenylation (GO:0018342)2.92458828
70base-excision repair, AP site formation (GO:0006285)2.91732478
71preassembly of GPI anchor in ER membrane (GO:0016254)2.90836199
72nucleoside triphosphate biosynthetic process (GO:0009142)2.89894532
73positive regulation of defense response to virus by host (GO:0002230)2.89770524
74rRNA methylation (GO:0031167)2.89214645
75hydrogen ion transmembrane transport (GO:1902600)2.88091389
76positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.88088453
77cullin deneddylation (GO:0010388)2.85653069
78ribosomal small subunit assembly (GO:0000028)2.81853016
79cellular component biogenesis (GO:0044085)2.80053786
80cytidine deamination (GO:0009972)2.76741867
81cytidine metabolic process (GO:0046087)2.76741867
82cytidine catabolic process (GO:0006216)2.76741867
83regulation of leukocyte mediated cytotoxicity (GO:0001910)2.75070780
84positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.75023800
85Arp2/3 complex-mediated actin nucleation (GO:0034314)2.72516317
86termination of RNA polymerase III transcription (GO:0006386)2.72511910
87transcription elongation from RNA polymerase III promoter (GO:0006385)2.72511910
88guanosine-containing compound biosynthetic process (GO:1901070)2.70113871
89fucose catabolic process (GO:0019317)2.70077622
90L-fucose metabolic process (GO:0042354)2.70077622
91L-fucose catabolic process (GO:0042355)2.70077622
92transcription from mitochondrial promoter (GO:0006390)2.69721974
93positive regulation of ligase activity (GO:0051351)2.69160403
94regulation of natural killer cell mediated immunity (GO:0002715)2.68239001
95regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.68239001
96cellular ketone body metabolic process (GO:0046950)2.67809491
97proton transport (GO:0015992)2.64423788
98tRNA metabolic process (GO:0006399)2.63040750
99regulation of mitotic spindle checkpoint (GO:1903504)2.61446680
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.61446680

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.03487736
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.47031678
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.19897617
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.31103492
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.19183127
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.07424138
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.83790740
8VDR_23849224_ChIP-Seq_CD4+_Human2.80000334
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.70286294
10VDR_22108803_ChIP-Seq_LS180_Human2.68423461
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59584633
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.53676651
13ZNF274_21170338_ChIP-Seq_K562_Hela2.42878292
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37714890
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.36273124
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22334090
17TAF15_26573619_Chip-Seq_HEK293_Human2.19368920
18FOXP3_21729870_ChIP-Seq_TREG_Human2.11703374
19ELK1_19687146_ChIP-ChIP_HELA_Human2.09522434
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07330959
21YY1_21170310_ChIP-Seq_MESCs_Mouse2.06814088
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89759434
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88905420
24MYC_18940864_ChIP-ChIP_HL60_Human1.86049421
25EWS_26573619_Chip-Seq_HEK293_Human1.74765723
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70970668
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.70312778
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.68774842
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68689258
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.68219908
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.66176337
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.65864219
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63749225
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56595751
35GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.55293522
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55276825
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54370849
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.49599807
39TTF2_22483619_ChIP-Seq_HELA_Human1.49532679
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45097105
41IGF1R_20145208_ChIP-Seq_DFB_Human1.44621931
42IRF1_19129219_ChIP-ChIP_H3396_Human1.44320345
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42820549
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41770811
45ER_23166858_ChIP-Seq_MCF-7_Human1.38087869
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.37785614
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36274722
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34513612
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33988175
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30509851
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27102966
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26285536
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25735230
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.25142133
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25142133
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24967245
57GABP_19822575_ChIP-Seq_HepG2_Human1.24340597
58P300_19829295_ChIP-Seq_ESCs_Human1.24204688
59HTT_18923047_ChIP-ChIP_STHdh_Human1.22566591
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17799995
61NCOR_22424771_ChIP-Seq_293T_Human1.17355872
62DCP1A_22483619_ChIP-Seq_HELA_Human1.16864492
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16550757
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16485184
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16394234
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14567320
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14477473
68NANOG_19829295_ChIP-Seq_ESCs_Human1.14431389
69SOX2_19829295_ChIP-Seq_ESCs_Human1.14431389
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.13598813
71GATA3_26560356_Chip-Seq_TH2_Human1.13464843
72TP53_22573176_ChIP-Seq_HFKS_Human1.12578375
73XRN2_22483619_ChIP-Seq_HELA_Human1.10830944
74RBPJ_21746931_ChIP-Seq_IB4_Human1.08960625
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08493836
76GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07667940
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05911159
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.05068376
79AR_20517297_ChIP-Seq_VCAP_Human1.03857855
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03758661
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02380785
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00365279
83PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99719257
84E2F7_22180533_ChIP-Seq_HELA_Human0.99685236
85GATA6_21074721_ChIP-Seq_CACO-2_Human0.99577224
86CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98394259
87PHF8_20622853_ChIP-Seq_HELA_Human0.98160618
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97491803
89FOXH1_21741376_ChIP-Seq_EPCs_Human0.97328772
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96819823
91GATA3_21878914_ChIP-Seq_MCF-7_Human0.96176475
92ETV1_20927104_ChIP-Seq_GIST48_Human0.95471114
93MYB_26560356_Chip-Seq_TH2_Human0.95433871
94CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93584160
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93380251
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92931768
97TDRD3_21172665_ChIP-Seq_MCF-7_Human0.92472632
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92461366
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92258611
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92227177

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot3.88795674
2MP0003878_abnormal_ear_physiology3.88795674
3MP0003786_premature_aging3.27047557
4MP0008877_abnormal_DNA_methylation3.21813860
5MP0005671_abnormal_response_to3.14696593
6MP0003195_calcinosis3.03622571
7MP0002102_abnormal_ear_morphology2.72889534
8MP0004147_increased_porphyrin_level2.70827622
9MP0005084_abnormal_gallbladder_morpholo2.44356112
10MP0006292_abnormal_olfactory_placode2.41754032
11MP0003693_abnormal_embryo_hatching2.39769666
12MP0004957_abnormal_blastocyst_morpholog2.34496801
13MP0009379_abnormal_foot_pigmentation2.22330277
14MP0009785_altered_susceptibility_to2.21647630
15MP0008995_early_reproductive_senescence2.08449571
16MP0010094_abnormal_chromosome_stability2.08158866
17MP0006072_abnormal_retinal_apoptosis1.91858009
18MP0003787_abnormal_imprinting1.87245312
19MP0004145_abnormal_muscle_electrophysio1.87129034
20MP0003567_abnormal_fetal_cardiomyocyte1.84316206
21MP0008872_abnormal_physiological_respon1.79934068
22MP0008058_abnormal_DNA_repair1.79816004
23MP0001485_abnormal_pinna_reflex1.73306069
24MP0000685_abnormal_immune_system1.61599895
25MP0001835_abnormal_antigen_presentation1.55619344
26MP0005551_abnormal_eye_electrophysiolog1.55228990
27MP0008875_abnormal_xenobiotic_pharmacok1.48121480
28MP0001800_abnormal_humoral_immune1.46224657
29MP0002876_abnormal_thyroid_physiology1.44386453
30MP0008961_abnormal_basal_metabolism1.41941878
31MP0003646_muscle_fatigue1.41444722
32MP0002736_abnormal_nociception_after1.38273461
33MP0001919_abnormal_reproductive_system1.37850646
34MP0003111_abnormal_nucleus_morphology1.36648833
35MP0001661_extended_life_span1.34830784
36MP0005365_abnormal_bile_salt1.30228410
37MP0006054_spinal_hemorrhage1.28323493
38MP0005253_abnormal_eye_physiology1.26977747
39MP0002751_abnormal_autonomic_nervous1.26695298
40MP0004043_abnormal_pH_regulation1.20026214
41MP0002277_abnormal_respiratory_mucosa1.16726903
42MP0003724_increased_susceptibility_to1.14407981
43MP0008007_abnormal_cellular_replicative1.13889998
44MP0005389_reproductive_system_phenotype1.12834480
45MP0009333_abnormal_splenocyte_physiolog1.12257823
46MP0000647_abnormal_sebaceous_gland1.11687606
47MP0003718_maternal_effect1.11451668
48MP0004142_abnormal_muscle_tone1.10531185
49MP0001501_abnormal_sleep_pattern1.08943484
50MP0004133_heterotaxia1.08719239
51MP0001529_abnormal_vocalization1.06008974
52MP0005000_abnormal_immune_tolerance1.03613128
53MP0002090_abnormal_vision0.98014870
54MP0002163_abnormal_gland_morphology0.96916092
55MP0006036_abnormal_mitochondrial_physio0.96200389
56MP0001765_abnormal_ion_homeostasis0.95793250
57MP0002006_tumorigenesis0.94603328
58MP0000372_irregular_coat_pigmentation0.93580304
59MP0008789_abnormal_olfactory_epithelium0.93225294
60MP0002723_abnormal_immune_serum0.91007388
61MP0006035_abnormal_mitochondrial_morpho0.91003958
62MP0002138_abnormal_hepatobiliary_system0.90818964
63MP0005379_endocrine/exocrine_gland_phen0.90739786
64MP0003806_abnormal_nucleotide_metabolis0.90535014
65MP0003186_abnormal_redox_activity0.89405524
66MP0005387_immune_system_phenotype0.86759986
67MP0001790_abnormal_immune_system0.86759986
68MP0001873_stomach_inflammation0.85844941
69MP0005646_abnormal_pituitary_gland0.85762165
70MP0002452_abnormal_antigen_presenting0.85506659
71MP0001188_hyperpigmentation0.85494387
72MP0001293_anophthalmia0.83920264
73MP0004742_abnormal_vestibular_system0.83463822
74MP0005085_abnormal_gallbladder_physiolo0.83130446
75MP0002420_abnormal_adaptive_immunity0.82878620
76MP0001819_abnormal_immune_cell0.81356968
77MP0002166_altered_tumor_susceptibility0.80177231
78MP0002148_abnormal_hypersensitivity_rea0.80166382
79MP0000689_abnormal_spleen_morphology0.79939274
80MP0002272_abnormal_nervous_system0.79872975
81MP0009764_decreased_sensitivity_to0.79738305
82MP0005645_abnormal_hypothalamus_physiol0.79080252
83MP0008932_abnormal_embryonic_tissue0.78605382
84MP0000631_abnormal_neuroendocrine_gland0.78537873
85MP0002398_abnormal_bone_marrow0.78274862
86MP0003959_abnormal_lean_body0.77740527
87MP0001764_abnormal_homeostasis0.77479950
88MP0003763_abnormal_thymus_physiology0.77064304
89MP0003011_delayed_dark_adaptation0.77051624
90MP0001119_abnormal_female_reproductive0.76620510
91MP0005410_abnormal_fertilization0.75524306
92MP0001968_abnormal_touch/_nociception0.75266903
93MP0001929_abnormal_gametogenesis0.74708954
94MP0000716_abnormal_immune_system0.74069859
95MP0002210_abnormal_sex_determination0.73866795
96MP0005075_abnormal_melanosome_morpholog0.73069922
97MP0003638_abnormal_response/metabolism_0.72324236
98MP0001845_abnormal_inflammatory_respons0.71711596
99MP0000703_abnormal_thymus_morphology0.71119629
100MP0004019_abnormal_vitamin_homeostasis0.69704972

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)4.39185266
2Increased hepatocellular lipid droplets (HP:0006565)4.34143175
3Lipid accumulation in hepatocytes (HP:0006561)4.20753979
4Mitochondrial inheritance (HP:0001427)4.05343768
5Increased CSF lactate (HP:0002490)3.96355481
6IgG deficiency (HP:0004315)3.92415490
7Hepatic necrosis (HP:0002605)3.88547700
8Renal Fanconi syndrome (HP:0001994)3.65136080
9Acute necrotizing encephalopathy (HP:0006965)3.65029691
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.34225248
11Absent/shortened dynein arms (HP:0200106)3.34225248
12Acute encephalopathy (HP:0006846)3.32377573
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.15031827
14Hypoproteinemia (HP:0003075)3.12183797
15Azoospermia (HP:0000027)3.05263617
16Increased serum lactate (HP:0002151)3.04208650
173-Methylglutaconic aciduria (HP:0003535)3.03225108
18Abnormal mitochondria in muscle tissue (HP:0008316)3.02929373
19Increased serum pyruvate (HP:0003542)2.99626681
20Testicular atrophy (HP:0000029)2.96112953
21Progressive macrocephaly (HP:0004481)2.95306049
22Congenital, generalized hypertrichosis (HP:0004540)2.93540983
23Exertional dyspnea (HP:0002875)2.83254113
24Abolished electroretinogram (ERG) (HP:0000550)2.79291655
25Brittle hair (HP:0002299)2.77096028
26Methylmalonic acidemia (HP:0002912)2.70976123
27Congenital stationary night blindness (HP:0007642)2.67283019
28Thyroid-stimulating hormone excess (HP:0002925)2.67048132
29CNS demyelination (HP:0007305)2.67028340
30Aplastic anemia (HP:0001915)2.65849921
31Hyperglycinemia (HP:0002154)2.61735710
32Cerebral edema (HP:0002181)2.58947955
33Pancytopenia (HP:0001876)2.57451970
34Type I transferrin isoform profile (HP:0003642)2.57399207
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.54587488
36Supernumerary spleens (HP:0009799)2.53075390
37Abnormal spermatogenesis (HP:0008669)2.43595829
38Glycosuria (HP:0003076)2.43319078
39Abnormality of urine glucose concentration (HP:0011016)2.43319078
40Increased intramyocellular lipid droplets (HP:0012240)2.40029922
41Severe combined immunodeficiency (HP:0004430)2.38771483
42Microvesicular hepatic steatosis (HP:0001414)2.37264482
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.34129549
44Lactic acidosis (HP:0003128)2.33383687
45Abnormality of glycolysis (HP:0004366)2.29586517
46Parakeratosis (HP:0001036)2.28943360
47Constricted visual fields (HP:0001133)2.27202168
48Methylmalonic aciduria (HP:0012120)2.25788747
49Optic disc pallor (HP:0000543)2.24143645
50Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23838469
51Abnormal protein N-linked glycosylation (HP:0012347)2.23838469
52Abnormal protein glycosylation (HP:0012346)2.23838469
53Abnormal glycosylation (HP:0012345)2.23838469
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.19782913
55Reticulocytopenia (HP:0001896)2.18340561
56Progressive inability to walk (HP:0002505)2.17742755
57Generalized aminoaciduria (HP:0002909)2.15275309
58Abnormal respiratory motile cilium morphology (HP:0005938)2.14358787
59Abnormal respiratory epithelium morphology (HP:0012253)2.14358787
60Abnormality of methionine metabolism (HP:0010901)2.12716571
61Abnormality of the labia minora (HP:0012880)2.11567699
62Respiratory failure (HP:0002878)2.11026406
63Large eyes (HP:0001090)2.10366845
64Hyperphosphaturia (HP:0003109)2.09569895
65Respiratory difficulties (HP:0002880)2.09533533
66T lymphocytopenia (HP:0005403)2.09346771
67Hypomagnesemia (HP:0002917)2.09275305
68Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.08235270
69Premature ovarian failure (HP:0008209)2.06397793
70Dyschromatopsia (HP:0007641)2.04679747
71Pancreatic cysts (HP:0001737)2.02732366
72Macrocytic anemia (HP:0001972)2.01800617
73Increased muscle lipid content (HP:0009058)2.01428128
74Hypoplasia of the uterus (HP:0000013)1.99120746
75Leukodystrophy (HP:0002415)1.98826507
76Renal cortical cysts (HP:0000803)1.97442117
77Chronic sinusitis (HP:0011109)1.97239343
78Lethargy (HP:0001254)1.96182955
79Abnormality of cells of the erythroid lineage (HP:0012130)1.94981364
80Increased IgM level (HP:0003496)1.93180538
81Elevated erythrocyte sedimentation rate (HP:0003565)1.92481458
82Abnormality of serine family amino acid metabolism (HP:0010894)1.92328544
83Abnormality of glycine metabolism (HP:0010895)1.92328544
84Abnormality of renal resorption (HP:0011038)1.90508389
85Abnormality of serum amino acid levels (HP:0003112)1.90012649
86Pancreatic fibrosis (HP:0100732)1.88834581
87Combined immunodeficiency (HP:0005387)1.87883535
88Emotional lability (HP:0000712)1.86864066
89Stomatitis (HP:0010280)1.86365817
90Abnormality of T cell number (HP:0011839)1.85848046
91Opisthotonus (HP:0002179)1.83341544
92Abnormality of sulfur amino acid metabolism (HP:0004339)1.81187801
93Adrenal hypoplasia (HP:0000835)1.80387271
94Type 2 muscle fiber atrophy (HP:0003554)1.78706413
95Abnormality of magnesium homeostasis (HP:0004921)1.78148141
96Colon cancer (HP:0003003)1.77749982
97Exercise intolerance (HP:0003546)1.76406686
98Aplasia/hypoplasia of the uterus (HP:0008684)1.76319481
99Thyroiditis (HP:0100646)1.76028445
100Abnormal number of erythroid precursors (HP:0012131)1.75519135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.91023443
2TXK4.77929275
3BUB14.45690505
4TLK14.44730830
5SCYL22.77062788
6TRIM282.72859330
7VRK22.64814364
8TIE12.43558308
9VRK12.39304861
10NUAK12.28855500
11TSSK62.05351689
12NME11.99968783
13GRK11.99536423
14MAP3K121.79749413
15MKNK11.78391115
16PLK31.72610077
17TAOK31.69344076
18STK161.60139390
19WNK41.58702824
20ADRBK21.51454663
21KDR1.50079779
22MKNK21.47592514
23TEC1.38772432
24MST41.35309029
25GRK61.33672906
26PBK1.27503579
27CDC71.26702141
28TAF11.13428637
29OXSR11.12450682
30BMPR21.11572054
31EIF2AK31.11313161
32TRPM71.08741740
33MAP4K11.07084539
34ALK1.04531323
35PDK21.01149257
36TNIK1.00336077
37ERBB30.98169177
38CDK190.86096246
39NEK10.85273361
40EIF2AK20.83052775
41DYRK20.80428715
42SRPK10.80105991
43PLK10.79333875
44AURKB0.75375965
45BCKDK0.72978191
46TESK20.72571634
47ITK0.72005248
48FES0.70868959
49RPS6KA40.70180766
50IKBKB0.69491288
51MYLK0.67596655
52EPHA40.66735594
53IKBKE0.65924999
54PHKG10.63825972
55PHKG20.63825972
56STK38L0.62020806
57TTK0.59387095
58IGF1R0.57859843
59PASK0.57733513
60STK390.57669886
61NEK20.53903967
62ATR0.53477344
63PIM10.52730168
64SYK0.52492701
65RPS6KA50.51864923
66WNK30.51147684
67DAPK10.50669879
68DAPK30.50152303
69CDK30.49868786
70MAPKAPK50.49789736
71MAP2K20.49547208
72INSRR0.47838074
73MAPKAPK30.45632507
74BTK0.45627742
75SIK30.44277649
76TBK10.43469041
77RPS6KB20.43024129
78LYN0.42518330
79CSNK2A10.42315725
80BCR0.40634576
81FRK0.39985375
82CSNK1G30.38885549
83PLK40.38861276
84CHEK20.37441092
85CSNK1G10.34346794
86CSNK2A20.34340284
87PLK20.33828843
88LCK0.33078732
89CSNK1A1L0.32817163
90BMPR1B0.31188918
91ATM0.30618748
92PRKCQ0.30448978
93CCNB10.30145035
94CHEK10.29264419
95PRKCI0.29036299
96MINK10.26852028
97MAP3K140.26841058
98WNK10.26383515
99PRKCA0.24195807
100CSNK1A10.23173590

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.49372125
2Oxidative phosphorylation_Homo sapiens_hsa001903.71975853
3Parkinsons disease_Homo sapiens_hsa050123.01905496
4Protein export_Homo sapiens_hsa030602.75334208
5Ribosome_Homo sapiens_hsa030102.46092059
6Homologous recombination_Homo sapiens_hsa034402.42830509
7RNA polymerase_Homo sapiens_hsa030202.34571015
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.17919507
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17362649
10Huntingtons disease_Homo sapiens_hsa050162.00787689
11DNA replication_Homo sapiens_hsa030301.90451922
12Alzheimers disease_Homo sapiens_hsa050101.89572543
13Asthma_Homo sapiens_hsa053101.86624863
14Mismatch repair_Homo sapiens_hsa034301.83860499
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.82174140
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81929495
17One carbon pool by folate_Homo sapiens_hsa006701.81766957
18Primary immunodeficiency_Homo sapiens_hsa053401.79181961
19RNA degradation_Homo sapiens_hsa030181.73451859
20Spliceosome_Homo sapiens_hsa030401.68884923
21Nitrogen metabolism_Homo sapiens_hsa009101.61935665
22Base excision repair_Homo sapiens_hsa034101.61546714
23Non-homologous end-joining_Homo sapiens_hsa034501.60280894
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56202397
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.52898332
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50687372
27Basal transcription factors_Homo sapiens_hsa030221.49794628
28Cardiac muscle contraction_Homo sapiens_hsa042601.48209056
29RNA transport_Homo sapiens_hsa030131.47037849
30Propanoate metabolism_Homo sapiens_hsa006401.45994048
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44954200
32Fanconi anemia pathway_Homo sapiens_hsa034601.39849212
33Tryptophan metabolism_Homo sapiens_hsa003801.32685464
34Nucleotide excision repair_Homo sapiens_hsa034201.27204286
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26749950
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26103600
37Autoimmune thyroid disease_Homo sapiens_hsa053201.24930454
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20945103
39Sulfur metabolism_Homo sapiens_hsa009201.13483408
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.12171857
41Linoleic acid metabolism_Homo sapiens_hsa005911.11853872
42Caffeine metabolism_Homo sapiens_hsa002321.10904995
43Selenocompound metabolism_Homo sapiens_hsa004501.10524896
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10437628
45Pyrimidine metabolism_Homo sapiens_hsa002401.10189155
46Allograft rejection_Homo sapiens_hsa053301.08973693
47Graft-versus-host disease_Homo sapiens_hsa053321.06140497
48Phototransduction_Homo sapiens_hsa047441.05630412
49Type I diabetes mellitus_Homo sapiens_hsa049401.04659639
50Purine metabolism_Homo sapiens_hsa002301.04354414
51Butanoate metabolism_Homo sapiens_hsa006500.98100691
52Systemic lupus erythematosus_Homo sapiens_hsa053220.94300822
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91424900
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90554823
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90510763
56Peroxisome_Homo sapiens_hsa041460.87541640
57Antigen processing and presentation_Homo sapiens_hsa046120.80105959
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77863898
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76750615
60Fat digestion and absorption_Homo sapiens_hsa049750.72559836
61Sulfur relay system_Homo sapiens_hsa041220.72182804
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71510085
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68148583
64Metabolic pathways_Homo sapiens_hsa011000.65205256
65Fatty acid elongation_Homo sapiens_hsa000620.64827910
66Rheumatoid arthritis_Homo sapiens_hsa053230.61000863
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54501288
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52169217
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.49845719
70Pyruvate metabolism_Homo sapiens_hsa006200.49803373
71Viral myocarditis_Homo sapiens_hsa054160.48567213
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48281868
73Fatty acid degradation_Homo sapiens_hsa000710.47788037
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46873400
75Cell cycle_Homo sapiens_hsa041100.45632698
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45543136
77Arachidonic acid metabolism_Homo sapiens_hsa005900.45494628
78beta-Alanine metabolism_Homo sapiens_hsa004100.43512118
79T cell receptor signaling pathway_Homo sapiens_hsa046600.42448963
80mRNA surveillance pathway_Homo sapiens_hsa030150.40287219
81Folate biosynthesis_Homo sapiens_hsa007900.39808237
82Glutathione metabolism_Homo sapiens_hsa004800.39093751
83Glycerolipid metabolism_Homo sapiens_hsa005610.38639409
84Olfactory transduction_Homo sapiens_hsa047400.38600286
85Steroid biosynthesis_Homo sapiens_hsa001000.37969842
86Epstein-Barr virus infection_Homo sapiens_hsa051690.35639234
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35242949
88Hematopoietic cell lineage_Homo sapiens_hsa046400.34364085
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33700651
90Oocyte meiosis_Homo sapiens_hsa041140.33076700
91Retinol metabolism_Homo sapiens_hsa008300.32472075
92Collecting duct acid secretion_Homo sapiens_hsa049660.32249725
93Vitamin digestion and absorption_Homo sapiens_hsa049770.31224887
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.30834234
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30642535
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.30501569
97Ether lipid metabolism_Homo sapiens_hsa005650.30037786
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29052489
99Tyrosine metabolism_Homo sapiens_hsa003500.26996034
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26887670

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