HNRNPA1P10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.37026583
2proteasome assembly (GO:0043248)4.18648709
3CENP-A containing nucleosome assembly (GO:0034080)4.04350506
4chromatin remodeling at centromere (GO:0031055)3.99599527
5metallo-sulfur cluster assembly (GO:0031163)3.85274188
6iron-sulfur cluster assembly (GO:0016226)3.85274188
7DNA replication-dependent nucleosome assembly (GO:0006335)3.81039956
8DNA replication-dependent nucleosome organization (GO:0034723)3.81039956
9DNA deamination (GO:0045006)3.72285235
10ribosome assembly (GO:0042255)3.70854434
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59832990
12DNA catabolic process, exonucleolytic (GO:0000738)3.59698377
13telomere maintenance via semi-conservative replication (GO:0032201)3.59658692
14cullin deneddylation (GO:0010388)3.55922378
15IMP biosynthetic process (GO:0006188)3.54216925
16establishment of protein localization to mitochondrial membrane (GO:0090151)3.51474939
17regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.43949478
18histone exchange (GO:0043486)3.42123925
19positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.41319468
20DNA strand elongation involved in DNA replication (GO:0006271)3.40251814
21somatic diversification of immune receptors via somatic mutation (GO:0002566)3.37697367
22somatic hypermutation of immunoglobulin genes (GO:0016446)3.37697367
23exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37602263
24nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.36139020
25protein deneddylation (GO:0000338)3.33291567
26GMP metabolic process (GO:0046037)3.31857444
27histone H2A acetylation (GO:0043968)3.31259147
28signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.28371122
29signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.28371122
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.28371122
31telomere maintenance via recombination (GO:0000722)3.28337955
32DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.28286557
33anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.25670724
34DNA strand elongation (GO:0022616)3.25603974
35establishment of integrated proviral latency (GO:0075713)3.24495727
36GTP biosynthetic process (GO:0006183)3.23614040
37purine nucleobase biosynthetic process (GO:0009113)3.23461874
38DNA damage response, detection of DNA damage (GO:0042769)3.23325194
39intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.22528858
40signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.22528858
41regulation of helicase activity (GO:0051095)3.22431716
42nucleobase biosynthetic process (GO:0046112)3.22068329
43non-recombinational repair (GO:0000726)3.20977425
44double-strand break repair via nonhomologous end joining (GO:0006303)3.20977425
45mitotic recombination (GO:0006312)3.20412854
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.19772572
47termination of RNA polymerase III transcription (GO:0006386)3.19772572
48signal transduction involved in cell cycle checkpoint (GO:0072395)3.17725810
49formation of translation preinitiation complex (GO:0001731)3.16833554
50signal transduction involved in DNA integrity checkpoint (GO:0072401)3.16353335
51signal transduction involved in DNA damage checkpoint (GO:0072422)3.16353335
52negative regulation of ligase activity (GO:0051352)3.15595742
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.15595742
54L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.15251004
55pseudouridine synthesis (GO:0001522)3.14649152
56regulation of cellular amino acid metabolic process (GO:0006521)3.12782928
57spliceosomal snRNP assembly (GO:0000387)3.12624697
58guanosine-containing compound biosynthetic process (GO:1901070)3.11954709
59nucleotide-excision repair, DNA gap filling (GO:0006297)3.07890623
60UTP biosynthetic process (GO:0006228)3.05243342
61DNA replication-independent nucleosome organization (GO:0034724)3.04319698
62DNA replication-independent nucleosome assembly (GO:0006336)3.04319698
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.03730547
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.03730547
65regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03026101
66regulation of mitotic spindle checkpoint (GO:1903504)3.03026101
67RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.02661550
68mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.02164458
69mitochondrial respiratory chain complex I assembly (GO:0032981)3.02164458
70NADH dehydrogenase complex assembly (GO:0010257)3.02164458
71folic acid-containing compound biosynthetic process (GO:0009396)3.00769552
72intra-S DNA damage checkpoint (GO:0031573)2.99088790
73IMP metabolic process (GO:0046040)2.94016017
74positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93124065
75mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.92254506
76UTP metabolic process (GO:0046051)2.91983238
77telomere maintenance via telomere lengthening (GO:0010833)2.90752040
78ATP synthesis coupled proton transport (GO:0015986)2.90614408
79energy coupled proton transport, down electrochemical gradient (GO:0015985)2.90614408
80DNA replication checkpoint (GO:0000076)2.89982356
81pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.89590575
82DNA ligation (GO:0006266)2.89544281
83mismatch repair (GO:0006298)2.89017505
84recombinational repair (GO:0000725)2.88264575
85water-soluble vitamin biosynthetic process (GO:0042364)2.86178256
86branched-chain amino acid catabolic process (GO:0009083)2.85174751
87mitotic metaphase plate congression (GO:0007080)2.84851911
88double-strand break repair via homologous recombination (GO:0000724)2.84767861
89pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.84366123
90somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.80627829
91isotype switching (GO:0045190)2.80627829
92somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.80627829
93ubiquinone biosynthetic process (GO:0006744)2.79060798
94positive regulation of ligase activity (GO:0051351)2.79049991
95CTP metabolic process (GO:0046036)2.78165451
96CTP biosynthetic process (GO:0006241)2.78165451
97pteridine-containing compound biosynthetic process (GO:0042559)2.77789882
98rRNA modification (GO:0000154)2.76699481
99replication fork processing (GO:0031297)2.75976522
100transcription-coupled nucleotide-excision repair (GO:0006283)2.75375821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.28644921
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.85713986
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.09931402
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67426965
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.61923518
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.39266185
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.13469800
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.07907843
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.05519293
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.97797560
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.82031113
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.78915984
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.74122184
14VDR_23849224_ChIP-Seq_CD4+_Human2.73886075
15ELK1_19687146_ChIP-ChIP_HELA_Human2.70905156
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63458227
17IGF1R_20145208_ChIP-Seq_DFB_Human2.50238579
18FOXP3_21729870_ChIP-Seq_TREG_Human2.46308462
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42332811
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34000043
21ZNF274_21170338_ChIP-Seq_K562_Hela2.30468638
22* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27432187
23FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.01584144
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00833585
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98753757
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.94360513
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94170014
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.93933725
29MYC_18940864_ChIP-ChIP_HL60_Human1.91670367
30IRF1_19129219_ChIP-ChIP_H3396_Human1.91617593
31VDR_22108803_ChIP-Seq_LS180_Human1.91144911
32DCP1A_22483619_ChIP-Seq_HELA_Human1.88073236
33EWS_26573619_Chip-Seq_HEK293_Human1.87347928
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87167028
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86048256
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85695115
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83714093
38GABP_19822575_ChIP-Seq_HepG2_Human1.82762543
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.82716187
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78833068
41TTF2_22483619_ChIP-Seq_HELA_Human1.73898734
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66663954
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64427012
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63859335
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61441487
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60183317
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55160615
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.53832441
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53578887
50TAF15_26573619_Chip-Seq_HEK293_Human1.46080459
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44188035
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41767745
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41015008
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.40050913
55XRN2_22483619_ChIP-Seq_HELA_Human1.38479597
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38137681
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.27943148
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26795504
59FUS_26573619_Chip-Seq_HEK293_Human1.25870094
60FOXM1_23109430_ChIP-Seq_U2OS_Human1.23758253
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22893294
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21993102
63AR_21909140_ChIP-Seq_LNCAP_Human1.21652015
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19314316
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18834307
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14069215
67CIITA_25753668_ChIP-Seq_RAJI_Human1.13328049
68SOX2_16153702_ChIP-ChIP_HESCs_Human1.12702836
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.12136086
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.10927725
71TP53_22573176_ChIP-Seq_HFKS_Human1.08781922
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07545206
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06494198
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05299318
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04372966
76KDM5A_27292631_Chip-Seq_BREAST_Human1.04182955
77IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03360592
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00541568
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98530999
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97455342
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97451723
82CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92343896
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91248233
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90420255
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90338121
86ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89705005
87P300_19829295_ChIP-Seq_ESCs_Human0.88371548
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85118618
89EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84883668
90ZFX_18555785_ChIP-Seq_MESCs_Mouse0.82076854
91ELK1_22589737_ChIP-Seq_MCF10A_Human0.82049553
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80959434
93ZFP57_27257070_Chip-Seq_ESCs_Mouse0.79953946
94CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79198484
95FOXA1_25329375_ChIP-Seq_VCAP_Human0.79033348
96FOXA1_27270436_Chip-Seq_PROSTATE_Human0.79033348
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78826375
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.78056197
99AR_20517297_ChIP-Seq_VCAP_Human0.76738674
100NANOG_19829295_ChIP-Seq_ESCs_Human0.76207569

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.36523831
2MP0010094_abnormal_chromosome_stability4.22244961
3MP0002102_abnormal_ear_morphology3.62990426
4MP0008877_abnormal_DNA_methylation3.54232126
5MP0003693_abnormal_embryo_hatching3.39863440
6MP0008057_abnormal_DNA_replication3.04863569
7MP0003786_premature_aging2.80272402
8MP0004957_abnormal_blastocyst_morpholog2.78986965
9MP0003111_abnormal_nucleus_morphology2.73589435
10MP0009697_abnormal_copulation2.71358751
11MP0006072_abnormal_retinal_apoptosis2.60142835
12MP0006292_abnormal_olfactory_placode2.40420636
13MP0003077_abnormal_cell_cycle2.32638658
14MP0008995_early_reproductive_senescence2.31188932
15MP0003718_maternal_effect2.27296304
16MP0008932_abnormal_embryonic_tissue2.16370010
17MP0001529_abnormal_vocalization2.08875992
18MP0004147_increased_porphyrin_level2.05362619
19MP0003567_abnormal_fetal_cardiomyocyte2.04399502
20MP0008007_abnormal_cellular_replicative2.00031244
21MP0008789_abnormal_olfactory_epithelium1.97544512
22MP0006035_abnormal_mitochondrial_morpho1.78869592
23MP0005645_abnormal_hypothalamus_physiol1.68234550
24MP0005253_abnormal_eye_physiology1.59408495
25MP0002938_white_spotting1.51653037
26MP0005499_abnormal_olfactory_system1.51081883
27MP0005394_taste/olfaction_phenotype1.51081883
28MP0005646_abnormal_pituitary_gland1.50446786
29MP0005671_abnormal_response_to1.48288979
30MP0002736_abnormal_nociception_after1.47288423
31MP0001764_abnormal_homeostasis1.42724855
32MP0006036_abnormal_mitochondrial_physio1.42395099
33MP0005084_abnormal_gallbladder_morpholo1.41012824
34MP0001929_abnormal_gametogenesis1.39046705
35MP0002210_abnormal_sex_determination1.36409922
36MP0001293_anophthalmia1.32331209
37MP0003806_abnormal_nucleotide_metabolis1.30975090
38MP0000372_irregular_coat_pigmentation1.30852797
39MP0008872_abnormal_physiological_respon1.30101152
40MP0008875_abnormal_xenobiotic_pharmacok1.23502064
41MP0002234_abnormal_pharynx_morphology1.22608992
42MP0005551_abnormal_eye_electrophysiolog1.21283287
43MP0002751_abnormal_autonomic_nervous1.21171219
44MP0003943_abnormal_hepatobiliary_system1.14633754
45MP0003880_abnormal_central_pattern1.14471105
46MP0001145_abnormal_male_reproductive1.12960160
47MP0001119_abnormal_female_reproductive1.12889789
48MP0000653_abnormal_sex_gland1.11877434
49MP0000049_abnormal_middle_ear1.10372498
50MP0006276_abnormal_autonomic_nervous1.09808527
51MP0005410_abnormal_fertilization1.08535111
52MP0002638_abnormal_pupillary_reflex1.02890741
53MP0002160_abnormal_reproductive_system1.01437422
54MP0003698_abnormal_male_reproductive1.01229729
55MP0000358_abnormal_cell_content/1.01228038
56MP0002233_abnormal_nose_morphology0.99439012
57MP0000465_gastrointestinal_hemorrhage0.99214384
58MP0001730_embryonic_growth_arrest0.98724060
59MP0004133_heterotaxia0.96141590
60MP0003186_abnormal_redox_activity0.95229348
61MP0003937_abnormal_limbs/digits/tail_de0.93778322
62MP0001661_extended_life_span0.90039215
63MP0005389_reproductive_system_phenotype0.88486548
64MP0003119_abnormal_digestive_system0.88389370
65MP0001697_abnormal_embryo_size0.84062569
66MP0000631_abnormal_neuroendocrine_gland0.81792661
67MP0001485_abnormal_pinna_reflex0.81764806
68MP0005377_hearing/vestibular/ear_phenot0.81318624
69MP0003878_abnormal_ear_physiology0.81318624
70MP0001968_abnormal_touch/_nociception0.81296323
71MP0000350_abnormal_cell_proliferation0.79413670
72MP0003787_abnormal_imprinting0.79077678
73MP0003763_abnormal_thymus_physiology0.77903140
74MP0001835_abnormal_antigen_presentation0.77354196
75MP0002006_tumorigenesis0.76744559
76MP0003121_genomic_imprinting0.76314886
77MP0000647_abnormal_sebaceous_gland0.75718095
78MP0002019_abnormal_tumor_incidence0.74124622
79MP0000313_abnormal_cell_death0.73964460
80MP0005391_vision/eye_phenotype0.72924646
81MP0002084_abnormal_developmental_patter0.72340014
82MP0004145_abnormal_muscle_electrophysio0.72323072
83MP0002282_abnormal_trachea_morphology0.70629283
84MP0005380_embryogenesis_phenotype0.70028301
85MP0001672_abnormal_embryogenesis/_devel0.70028301
86MP0002254_reproductive_system_inflammat0.69944383
87MP0002166_altered_tumor_susceptibility0.69014981
88MP0004197_abnormal_fetal_growth/weight/0.68900901
89MP0001986_abnormal_taste_sensitivity0.68356466
90MP0005075_abnormal_melanosome_morpholog0.66373979
91MP0001919_abnormal_reproductive_system0.65973601
92MP0002009_preneoplasia0.65471319
93MP0003938_abnormal_ear_development0.64918890
94MP0010386_abnormal_urinary_bladder0.64796584
95MP0001188_hyperpigmentation0.63725522
96MP0000639_abnormal_adrenal_gland0.63593492
97MP0002080_prenatal_lethality0.63244115
98MP0002085_abnormal_embryonic_tissue0.62752917
99MP0001286_abnormal_eye_development0.61260529
100MP0005395_other_phenotype0.60424695

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)3.35311154
2Acute necrotizing encephalopathy (HP:0006965)3.33937708
3Acute encephalopathy (HP:0006846)3.22139538
4Increased CSF lactate (HP:0002490)3.14564231
5Dyschromatopsia (HP:0007641)3.06209699
6Mitochondrial inheritance (HP:0001427)3.03503110
7Abnormality of the labia minora (HP:0012880)3.00302280
8Increased hepatocellular lipid droplets (HP:0006565)2.93316232
9Aplastic anemia (HP:0001915)2.90693222
10Abnormal mitochondria in muscle tissue (HP:0008316)2.87678039
11Lipid accumulation in hepatocytes (HP:0006561)2.86721259
12Hyperglycinemia (HP:0002154)2.85611105
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83579054
14Microvesicular hepatic steatosis (HP:0001414)2.77917423
15Meckel diverticulum (HP:0002245)2.74686754
163-Methylglutaconic aciduria (HP:0003535)2.73827148
17Methylmalonic acidemia (HP:0002912)2.73377886
18Increased serum lactate (HP:0002151)2.71348941
19Colon cancer (HP:0003003)2.67639039
20Pancreatic cysts (HP:0001737)2.67512279
21Abnormality of the ileum (HP:0001549)2.66066153
22Progressive macrocephaly (HP:0004481)2.57535481
23Hepatocellular necrosis (HP:0001404)2.56636751
24Abnormal lung lobation (HP:0002101)2.56448731
25Abnormality of midbrain morphology (HP:0002418)2.52988393
26Molar tooth sign on MRI (HP:0002419)2.52988393
27Chromsome breakage (HP:0040012)2.52919949
28Pancytopenia (HP:0001876)2.52518802
29Pancreatic fibrosis (HP:0100732)2.48075660
30Cerebral edema (HP:0002181)2.42682204
31Abnormality of glycine metabolism (HP:0010895)2.40522940
32Abnormality of serine family amino acid metabolism (HP:0010894)2.40522940
33Intestinal atresia (HP:0011100)2.36895496
34Hyperglycinuria (HP:0003108)2.31183034
35Abnormality of the anterior horn cell (HP:0006802)2.29595858
36Degeneration of anterior horn cells (HP:0002398)2.29595858
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.28931090
38IgG deficiency (HP:0004315)2.28682174
39Type I transferrin isoform profile (HP:0003642)2.28557561
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25731509
41Abolished electroretinogram (ERG) (HP:0000550)2.24122740
42Abnormal biliary tract physiology (HP:0012439)2.23093354
43Bile duct proliferation (HP:0001408)2.23093354
44Hepatic necrosis (HP:0002605)2.22780071
45Pendular nystagmus (HP:0012043)2.20600346
46Lactic acidosis (HP:0003128)2.20293330
47Hypoproteinemia (HP:0003075)2.20035074
48Medial flaring of the eyebrow (HP:0010747)2.17554182
49Methylmalonic aciduria (HP:0012120)2.15489288
50Small intestinal stenosis (HP:0012848)2.12463975
51Duodenal stenosis (HP:0100867)2.12463975
52Renal Fanconi syndrome (HP:0001994)2.12025782
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11798804
54Increased serum pyruvate (HP:0003542)2.11434315
55Abnormal protein glycosylation (HP:0012346)2.10698889
56Abnormal glycosylation (HP:0012345)2.10698889
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10698889
58Abnormal protein N-linked glycosylation (HP:0012347)2.10698889
59Abnormality of the preputium (HP:0100587)2.10568735
60Nephronophthisis (HP:0000090)2.07106394
61Abnormality of serum amino acid levels (HP:0003112)2.06433311
62Abnormality of chromosome stability (HP:0003220)2.02101021
63Constricted visual fields (HP:0001133)1.99990521
64Abnormality of glycolysis (HP:0004366)1.98781240
65Abnormality of the duodenum (HP:0002246)1.97359926
66Congenital primary aphakia (HP:0007707)1.95702500
67Sloping forehead (HP:0000340)1.95425210
68Lethargy (HP:0001254)1.95242404
69Optic disc pallor (HP:0000543)1.94818787
70Opisthotonus (HP:0002179)1.93518981
71Sclerocornea (HP:0000647)1.91948332
72Abnormal rod and cone electroretinograms (HP:0008323)1.91840751
73Horseshoe kidney (HP:0000085)1.88825296
74Aplasia/Hypoplasia of the tongue (HP:0010295)1.88405102
75Male pseudohermaphroditism (HP:0000037)1.86780328
76Renal cortical cysts (HP:0000803)1.86099824
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85042290
78Abnormality of methionine metabolism (HP:0010901)1.84687905
79Ependymoma (HP:0002888)1.84493783
80Decreased activity of mitochondrial respiratory chain (HP:0008972)1.84343755
81Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.84343755
82B lymphocytopenia (HP:0010976)1.84200346
83Abnormality of B cell number (HP:0010975)1.83073679
84Abnormality of the prostate (HP:0008775)1.83068230
85Nephrogenic diabetes insipidus (HP:0009806)1.82965835
86Atrophy/Degeneration involving motor neurons (HP:0007373)1.81226776
87Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79917923
88Congenital stationary night blindness (HP:0007642)1.79536936
89Multiple enchondromatosis (HP:0005701)1.79122147
90Gait imbalance (HP:0002141)1.77835658
91Respiratory failure (HP:0002878)1.75958726
92Abnormality of the vitamin B12 metabolism (HP:0004341)1.75737524
93Attenuation of retinal blood vessels (HP:0007843)1.72564617
94Postaxial foot polydactyly (HP:0001830)1.72284920
95Short tibia (HP:0005736)1.72072670
96Severe combined immunodeficiency (HP:0004430)1.70785074
97Increased intramyocellular lipid droplets (HP:0012240)1.70151845
98Decreased electroretinogram (ERG) amplitude (HP:0000654)1.69297252
99Triphalangeal thumb (HP:0001199)1.68790969
100Panhypogammaglobulinemia (HP:0003139)1.68367289

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.09669102
2VRK23.49771303
3MST43.27251731
4VRK13.16199850
5SRPK12.96022612
6EIF2AK32.76571694
7PBK2.76251486
8BUB12.67443486
9MAP4K22.51881671
10TRIM282.33977607
11TLK12.25555264
12NUAK12.25376423
13TSSK62.24027409
14MKNK12.09133552
15NEK12.03596600
16EIF2AK11.88727928
17PLK31.87043072
18CDC71.84309978
19TXK1.73178902
20STK391.66200845
21WEE11.64031046
22MKNK21.58715910
23NME11.54157141
24BCKDK1.52458979
25BCR1.47568372
26TTK1.46069071
27WNK31.45730812
28TAF11.43957024
29BRSK21.41896214
30OXSR11.38181733
31PLK41.32668188
32INSRR1.24247774
33PLK11.17692428
34STK38L1.14241189
35BMPR1B1.11632143
36ATR1.10066376
37MAP2K71.00003944
38AURKB0.98585394
39GRK10.97280661
40DYRK20.96865529
41PASK0.96601253
42CSNK1G30.94303565
43CDK190.93480288
44EIF2AK20.92118471
45CSNK1G10.91296557
46CHEK20.90012979
47MAP3K40.87555632
48STK160.86050487
49ADRBK20.85728970
50WNK40.85535634
51ACVR1B0.85175994
52ERBB30.83263341
53RPS6KA40.82851457
54DAPK10.82414149
55SCYL20.81652217
56AURKA0.80847127
57CSNK1A1L0.80537703
58MAP3K120.79187374
59KDR0.76630730
60FLT30.76004256
61BRD40.73275559
62TNIK0.70375875
63BRSK10.67690627
64RPS6KA50.67084274
65TAOK30.65875613
66ATM0.63220807
67CSNK1G20.60904416
68PLK20.59111966
69CASK0.57080619
70PINK10.56966569
71CHEK10.56285332
72DYRK30.51092345
73CDK70.50858771
74PDK20.50380465
75NEK90.47796851
76CSNK2A10.47061251
77CCNB10.45634697
78PAK30.41002541
79FGFR10.40764933
80TGFBR10.39943444
81PRKCE0.38992623
82CSNK2A20.38349553
83NEK20.38027630
84STK40.35976740
85TESK20.34577481
86EPHA30.34434658
87MAP3K50.33779251
88MAPK130.33506323
89STK30.30180562
90ALK0.28197533
91AKT20.26000836
92CDK10.25910445
93CDK30.25017266
94DAPK30.24885591
95BMPR20.24770442
96TEC0.24477381
97CSNK1A10.23963025
98CDK90.23672985
99IKBKB0.22446773
100CDK60.22171454

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.13985192
2Mismatch repair_Homo sapiens_hsa034303.31128438
3DNA replication_Homo sapiens_hsa030303.22695120
4Protein export_Homo sapiens_hsa030603.07927658
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.72309709
6Non-homologous end-joining_Homo sapiens_hsa034502.68257164
7Homologous recombination_Homo sapiens_hsa034402.65738085
8Base excision repair_Homo sapiens_hsa034102.59531255
9RNA polymerase_Homo sapiens_hsa030202.57904015
10Basal transcription factors_Homo sapiens_hsa030222.38325562
11Spliceosome_Homo sapiens_hsa030402.30111251
12Nucleotide excision repair_Homo sapiens_hsa034202.24511177
13One carbon pool by folate_Homo sapiens_hsa006702.20483616
14RNA transport_Homo sapiens_hsa030132.15936899
15Fanconi anemia pathway_Homo sapiens_hsa034602.13495479
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09496911
17RNA degradation_Homo sapiens_hsa030182.05593807
18Oxidative phosphorylation_Homo sapiens_hsa001901.97846579
19Propanoate metabolism_Homo sapiens_hsa006401.92426222
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81189497
21Parkinsons disease_Homo sapiens_hsa050121.79806631
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77661822
23Pyrimidine metabolism_Homo sapiens_hsa002401.77462554
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64641043
25Systemic lupus erythematosus_Homo sapiens_hsa053221.56515013
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50383585
27Primary immunodeficiency_Homo sapiens_hsa053401.35893183
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.34902894
29Cell cycle_Homo sapiens_hsa041101.34900255
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33994992
31Steroid biosynthesis_Homo sapiens_hsa001001.30427442
32Huntingtons disease_Homo sapiens_hsa050161.30346911
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29361281
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28530899
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27804597
36Purine metabolism_Homo sapiens_hsa002301.26062394
37Ribosome_Homo sapiens_hsa030101.22099953
38Fatty acid elongation_Homo sapiens_hsa000621.13103665
39Butanoate metabolism_Homo sapiens_hsa006501.06030800
40mRNA surveillance pathway_Homo sapiens_hsa030151.05388400
41Folate biosynthesis_Homo sapiens_hsa007901.04121689
42Pyruvate metabolism_Homo sapiens_hsa006201.02100923
43Asthma_Homo sapiens_hsa053100.91239819
44Alcoholism_Homo sapiens_hsa050340.91035452
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89555462
46Vitamin B6 metabolism_Homo sapiens_hsa007500.85787135
47Alzheimers disease_Homo sapiens_hsa050100.83032761
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82722568
49Nitrogen metabolism_Homo sapiens_hsa009100.82649632
50Carbon metabolism_Homo sapiens_hsa012000.81583719
51Peroxisome_Homo sapiens_hsa041460.80505677
52Glutathione metabolism_Homo sapiens_hsa004800.79567637
53Phototransduction_Homo sapiens_hsa047440.79153809
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.79080232
55Regulation of autophagy_Homo sapiens_hsa041400.78329630
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78212747
57Oocyte meiosis_Homo sapiens_hsa041140.75155191
58Allograft rejection_Homo sapiens_hsa053300.73342495
59Selenocompound metabolism_Homo sapiens_hsa004500.73066630
60Biosynthesis of amino acids_Homo sapiens_hsa012300.72023500
61Autoimmune thyroid disease_Homo sapiens_hsa053200.71028590
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67860394
63Tryptophan metabolism_Homo sapiens_hsa003800.67652534
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65773852
65Metabolic pathways_Homo sapiens_hsa011000.65694756
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64779476
67p53 signaling pathway_Homo sapiens_hsa041150.61911687
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60737526
69Antigen processing and presentation_Homo sapiens_hsa046120.60083838
70Sulfur relay system_Homo sapiens_hsa041220.59807250
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59559894
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57256817
73Caffeine metabolism_Homo sapiens_hsa002320.55710795
74beta-Alanine metabolism_Homo sapiens_hsa004100.53045279
75Fatty acid metabolism_Homo sapiens_hsa012120.50074996
76Viral carcinogenesis_Homo sapiens_hsa052030.46022252
77Type I diabetes mellitus_Homo sapiens_hsa049400.45829906
78Epstein-Barr virus infection_Homo sapiens_hsa051690.44202142
79Sulfur metabolism_Homo sapiens_hsa009200.44049295
80N-Glycan biosynthesis_Homo sapiens_hsa005100.41587730
81Fatty acid degradation_Homo sapiens_hsa000710.41417793
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.39920736
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38817658
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.37823730
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37664461
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36313421
87Graft-versus-host disease_Homo sapiens_hsa053320.36265391
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35546514
89Ether lipid metabolism_Homo sapiens_hsa005650.34454010
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.34252845
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33603760
92Linoleic acid metabolism_Homo sapiens_hsa005910.32457452
93Olfactory transduction_Homo sapiens_hsa047400.30986806
94Arginine and proline metabolism_Homo sapiens_hsa003300.30756332
95Taste transduction_Homo sapiens_hsa047420.30367551
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27598265
97Cardiac muscle contraction_Homo sapiens_hsa042600.26445541
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25403059
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24469978
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22510844

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