ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of isotype switching to IgG isotypes (GO:0048302)	5.96258540
2	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	5.65509684
3	regulation of immunoglobulin secretion (GO:0051023)	5.39130206
4	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.92488850
5	base-excision repair, AP site formation (GO:0006285)	4.66844622
6	rRNA methylation (GO:0031167)	4.58619694
7	rRNA modification (GO:0000154)	4.54305217
8	regulation of regulatory T cell differentiation (GO:0045589)	4.45300279
9	GTP biosynthetic process (GO:0006183)	4.42068284
10	positive regulation of DNA recombination (GO:0045911)	4.38508476
11	pseudouridine synthesis (GO:0001522)	4.23234807
12	protein complex biogenesis (GO:0070271)	4.18905119
13	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.17015675
14	positive regulation of isotype switching (GO:0045830)	4.14955789
15	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.11589210
16	chaperone-mediated protein transport (GO:0072321)	4.11428331
17	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.08752764
18	ATP synthesis coupled proton transport (GO:0015986)	4.08752764
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.06008350
20	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.06008350
21	NADH dehydrogenase complex assembly (GO:0010257)	4.06008350
22	DNA deamination (GO:0045006)	3.98528535
23	mitochondrial respiratory chain complex assembly (GO:0033108)	3.98226807
24	retinal cone cell development (GO:0046549)	3.91873947
25	protein polyglutamylation (GO:0018095)	3.84943283
26	UTP metabolic process (GO:0046051)	3.84423984
27	UTP biosynthetic process (GO:0006228)	3.72809399
28	respiratory chain complex IV assembly (GO:0008535)	3.72619657
29	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.69940895
30	regulation of chronic inflammatory response (GO:0002676)	3.62357966
31	positive regulation of immunoglobulin production (GO:0002639)	3.56992903
32	mitochondrial RNA metabolic process (GO:0000959)	3.54294547
33	positive regulation of interleukin-17 production (GO:0032740)	3.53491027
34	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.52480087
35	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.48180412
36	water-soluble vitamin biosynthetic process (GO:0042364)	3.37706743
37	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	3.35803110
38	transcription from mitochondrial promoter (GO:0006390)	3.34285444
39	inner mitochondrial membrane organization (GO:0007007)	3.33072269
40	DNA damage response, detection of DNA damage (GO:0042769)	3.30931424
41	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.29605834
42	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.29605834
43	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.27747104
44	negative regulation of B cell apoptotic process (GO:0002903)	3.27523532
45	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.26392839
46	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.26392839
47	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.26383446
48	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.25521744
49	regulation of mitotic spindle checkpoint (GO:1903504)	3.25521744
50	L-methionine salvage (GO:0071267)	3.22781252
51	L-methionine biosynthetic process (GO:0071265)	3.22781252
52	amino acid salvage (GO:0043102)	3.22781252
53	DNA replication-dependent nucleosome organization (GO:0034723)	3.19688036
54	DNA replication-dependent nucleosome assembly (GO:0006335)	3.19688036
55	proteasome assembly (GO:0043248)	3.18856900
56	CTP metabolic process (GO:0046036)	3.18020356
57	CTP biosynthetic process (GO:0006241)	3.18020356
58	ribosomal small subunit assembly (GO:0000028)	3.14027949
59	cytochrome complex assembly (GO:0017004)	3.06463065
60	positive regulation of activated T cell proliferation (GO:0042104)	3.05614147
61	ribosome biogenesis (GO:0042254)	3.03777903
62	adaptation of signaling pathway (GO:0023058)	3.01193399
63	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.97175277
64	retinal rod cell development (GO:0046548)	2.95241128
65	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.93700125
66	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.93410650
67	intracellular protein transmembrane import (GO:0044743)	2.93174996
68	guanosine-containing compound biosynthetic process (GO:1901070)	2.93140129
69	positive regulation of B cell mediated immunity (GO:0002714)	2.92383969
70	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.92383969
71	folic acid-containing compound biosynthetic process (GO:0009396)	2.90207902
72	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.89610574
73	negative regulation of T-helper cell differentiation (GO:0045623)	2.89610574
74	cellular component biogenesis (GO:0044085)	2.89589632
75	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.88603285
76	deoxyribonucleotide catabolic process (GO:0009264)	2.83721213
77	tRNA processing (GO:0008033)	2.82956948
78	methionine biosynthetic process (GO:0009086)	2.81555143
79	respiratory electron transport chain (GO:0022904)	2.81125258
80	electron transport chain (GO:0022900)	2.80764758
81	termination of RNA polymerase III transcription (GO:0006386)	2.80690177
82	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.80690177
83	nucleoside diphosphate phosphorylation (GO:0006165)	2.79613656
84	histone exchange (GO:0043486)	2.78927005
85	chromatin remodeling at centromere (GO:0031055)	2.75655963
86	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.74891601
87	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.72904557
88	CENP-A containing nucleosome assembly (GO:0034080)	2.72755839
89	regulation of isotype switching (GO:0045191)	2.72197276
90	regulation of podosome assembly (GO:0071801)	2.71830130
91	rRNA processing (GO:0006364)	2.69120796
92	regulation of immunoglobulin production (GO:0002637)	2.69076136
93	deoxyribose phosphate catabolic process (GO:0046386)	2.67633909
94	platelet dense granule organization (GO:0060155)	2.67631230
95	rRNA metabolic process (GO:0016072)	2.67603395
96	negative regulation of acute inflammatory response (GO:0002674)	2.64897860
97	transcription-coupled nucleotide-excision repair (GO:0006283)	2.64451692
98	nucleotide transmembrane transport (GO:1901679)	2.62538712
99	mismatch repair (GO:0006298)	2.61375145
100	purine deoxyribonucleotide catabolic process (GO:0009155)	2.60768568

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.44051185
2	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.00279321
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.91892152
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.12322399
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.04787546
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.88099733
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.85445303
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.80712417
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.68243260
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.67951053
11	E2F7_22180533_ChIP-Seq_HELA_Human	2.47874685
12	FOXP3_21729870_ChIP-Seq_TREG_Human	2.43679888
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.43492899
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.43015256
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.42072855
16	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.40196731
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.34291827
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.31409327
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.21785587
20	EWS_26573619_Chip-Seq_HEK293_Human	2.16250636
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.12917249
22	ELK1_19687146_ChIP-ChIP_HELA_Human	2.11821954
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.09334769
24	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.04989956
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.02585396
26	MYC_18940864_ChIP-ChIP_HL60_Human	2.01515497
27	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.00154211
28	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.94494020
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.92827221
30	FUS_26573619_Chip-Seq_HEK293_Human	1.92495398
31	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.90187006
32	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.81268587
33	IGF1R_20145208_ChIP-Seq_DFB_Human	1.64825291
34	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.63662769
35	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.59942654
36	VDR_22108803_ChIP-Seq_LS180_Human	1.59375993
37	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.57801356
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57737721
39	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.57048762
40	TTF2_22483619_ChIP-Seq_HELA_Human	1.52932304
41	P300_19829295_ChIP-Seq_ESCs_Human	1.44190367
42	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.44035808
43	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.40989602
44	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.36557300
45	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.36184442
46	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.35501869
47	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.32634608
48	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.32266394
49	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31245262
50	DCP1A_22483619_ChIP-Seq_HELA_Human	1.30968518
51	GBX2_23144817_ChIP-Seq_PC3_Human	1.30300972
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.28292731
53	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.27495272
54	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.26901760
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.26606705
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.24181439
57	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.24181439
58	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.22464141
59	TP53_22573176_ChIP-Seq_HFKS_Human	1.22317200
60	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.20390344
61	GABP_19822575_ChIP-Seq_HepG2_Human	1.19994660
62	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.19305566
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18307228
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18307228
65	EZH2_22144423_ChIP-Seq_EOC_Human	1.17810089
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16850749
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.15954140
68	NCOR_22424771_ChIP-Seq_293T_Human	1.14725374
69	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.11649216
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11437454
71	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.11334774
72	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.10824412
73	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.10587265
74	BCAT_22108803_ChIP-Seq_LS180_Human	1.10169694
75	XRN2_22483619_ChIP-Seq_HELA_Human	1.08985404
76	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.08749893
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06080521
78	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.05582817
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05385469
80	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03215444
81	GATA3_26560356_Chip-Seq_TH2_Human	1.03055515
82	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.01153418
83	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.99650156
84	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.98423103
85	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97241786
86	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97241786
87	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.96963535
88	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.96750177
89	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.94459338
90	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.93407968
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.93363331
92	PHF8_20622853_ChIP-Seq_HELA_Human	0.91782347
93	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.91543343
94	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.90871093
95	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.90359536
96	NFYB_21822215_ChIP-Seq_K562_Human	0.89941882
97	TCF4_22108803_ChIP-Seq_LS180_Human	0.89512823
98	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.88526990
99	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.87775168
100	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.86047288

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001348_abnormal_lacrimal_gland	3.76509900
2	MP0003787_abnormal_imprinting	3.64226724
3	MP0008872_abnormal_physiological_respon	3.14297100
4	MP0008877_abnormal_DNA_methylation	2.98438959
5	MP0006292_abnormal_olfactory_placode	2.95680996
6	MP0003646_muscle_fatigue	2.62351440
7	MP0002736_abnormal_nociception_after	2.53218191
8	MP0001835_abnormal_antigen_presentation	2.52804241
9	MP0008875_abnormal_xenobiotic_pharmacok	2.37627187
10	MP0003786_premature_aging	2.35007402
11	MP0006072_abnormal_retinal_apoptosis	2.20130472
12	MP0004957_abnormal_blastocyst_morpholog	2.15695279
13	MP0002102_abnormal_ear_morphology	2.15693027
14	MP0008058_abnormal_DNA_repair	2.11082958
15	MP0000465_gastrointestinal_hemorrhage	2.09614723
16	MP0010094_abnormal_chromosome_stability	2.08837341
17	MP0004885_abnormal_endolymph	2.06455456
18	MP0005377_hearing/vestibular/ear_phenot	2.03549015
19	MP0003878_abnormal_ear_physiology	2.03549015
20	MP0005646_abnormal_pituitary_gland	1.93527392
21	MP0000604_amyloidosis	1.89743119
22	MP0001873_stomach_inflammation	1.82845914
23	MP0006036_abnormal_mitochondrial_physio	1.80261574
24	MP0009379_abnormal_foot_pigmentation	1.75160037
25	MP0001968_abnormal_touch/_nociception	1.73570813
26	MP0005551_abnormal_eye_electrophysiolog	1.72856289
27	MP0003718_maternal_effect	1.69802616
28	MP0005671_abnormal_response_to	1.67483107
29	MP0002254_reproductive_system_inflammat	1.67045376
30	MP0003693_abnormal_embryo_hatching	1.66201841
31	MP0005085_abnormal_gallbladder_physiolo	1.59839335
32	MP0000613_abnormal_salivary_gland	1.55334434
33	MP0003045_fibrosis	1.51995016
34	MP0003941_abnormal_skin_development	1.50197971
35	MP0002148_abnormal_hypersensitivity_rea	1.47085366
36	MP0005410_abnormal_fertilization	1.46602794
37	MP0009333_abnormal_splenocyte_physiolog	1.44755213
38	MP0004142_abnormal_muscle_tone	1.43719717
39	MP0001919_abnormal_reproductive_system	1.41350878
40	MP0002234_abnormal_pharynx_morphology	1.40132665
41	MP0005253_abnormal_eye_physiology	1.37371766
42	MP0003195_calcinosis	1.35960416
43	MP0002138_abnormal_hepatobiliary_system	1.35144662
44	MP0005389_reproductive_system_phenotype	1.35011596
45	MP0001293_anophthalmia	1.33817488
46	MP0002837_dystrophic_cardiac_calcinosis	1.32152023
47	MP0005075_abnormal_melanosome_morpholog	1.29499752
48	MP0003121_genomic_imprinting	1.21818655
49	MP0001853_heart_inflammation	1.21104782
50	MP0002160_abnormal_reproductive_system	1.19831088
51	MP0005360_urolithiasis	1.18624521
52	MP0005645_abnormal_hypothalamus_physiol	1.13113781
53	MP0003937_abnormal_limbs/digits/tail_de	1.11373951
54	MP0003119_abnormal_digestive_system	1.10642834
55	MP0003111_abnormal_nucleus_morphology	1.09744587
56	MP0005310_abnormal_salivary_gland	1.09413584
57	MP0001529_abnormal_vocalization	1.08878485
58	MP0003567_abnormal_fetal_cardiomyocyte	1.07743601
59	MP0005387_immune_system_phenotype	1.06684915
60	MP0001790_abnormal_immune_system	1.06684915
61	MP0002272_abnormal_nervous_system	1.00635522
62	MP0003300_gastrointestinal_ulcer	0.99263685
63	MP0010386_abnormal_urinary_bladder	0.96218918
64	MP0008789_abnormal_olfactory_epithelium	0.96105761
65	MP0005395_other_phenotype	0.95882414
66	MP0001929_abnormal_gametogenesis	0.95509937
67	MP0002163_abnormal_gland_morphology	0.94595466
68	MP0003186_abnormal_redox_activity	0.93996643
69	MP0006035_abnormal_mitochondrial_morpho	0.93752128
70	MP0005379_endocrine/exocrine_gland_phen	0.93193378
71	MP0001764_abnormal_homeostasis	0.93188286
72	MP0002277_abnormal_respiratory_mucosa	0.91622323
73	MP0002006_tumorigenesis	0.90288713
74	MP0002210_abnormal_sex_determination	0.89569370
75	MP0002693_abnormal_pancreas_physiology	0.89168219
76	MP0001765_abnormal_ion_homeostasis	0.87270426
77	MP0002938_white_spotting	0.87201546
78	MP0001984_abnormal_olfaction	0.86259188
79	MP0000653_abnormal_sex_gland	0.86165491
80	MP0005636_abnormal_mineral_homeostasis	0.85980516
81	MP0005084_abnormal_gallbladder_morpholo	0.82950294
82	MP0002876_abnormal_thyroid_physiology	0.82246070
83	MP0005167_abnormal_blood-brain_barrier	0.81256927
84	MP0000537_abnormal_urethra_morphology	0.80259566
85	MP0004133_heterotaxia	0.80092441
86	MP0000049_abnormal_middle_ear	0.79696042
87	MP0001145_abnormal_male_reproductive	0.76658359
88	MP0001905_abnormal_dopamine_level	0.76074488
89	MP0008775_abnormal_heart_ventricle	0.75932385
90	MP0004145_abnormal_muscle_electrophysio	0.72581654
91	MP0002733_abnormal_thermal_nociception	0.71401575
92	MP0003698_abnormal_male_reproductive	0.70743207
93	MP0001501_abnormal_sleep_pattern	0.69550774
94	MP0003122_maternal_imprinting	0.69412530
95	MP0003077_abnormal_cell_cycle	0.68983588
96	MP0010329_abnormal_lipoprotein_level	0.68546576
97	MP0000631_abnormal_neuroendocrine_gland	0.67851664
98	MP0001119_abnormal_female_reproductive	0.67212263
99	MP0004742_abnormal_vestibular_system	0.67053004
100	MP0001485_abnormal_pinna_reflex	0.66923212

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.31016306
2	Increased hepatocellular lipid droplets (HP:0006565)	4.18608984
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.05726882
4	Lipid accumulation in hepatocytes (HP:0006561)	3.93863178
5	Mitochondrial inheritance (HP:0001427)	3.90172523
6	Increased intramyocellular lipid droplets (HP:0012240)	3.88190047
7	Acute encephalopathy (HP:0006846)	3.79607727
8	Congenital stationary night blindness (HP:0007642)	3.76555000
9	Increased CSF lactate (HP:0002490)	3.72382672
10	Abnormality of alanine metabolism (HP:0010916)	3.63085437
11	Hyperalaninemia (HP:0003348)	3.63085437
12	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.63085437
13	Progressive macrocephaly (HP:0004481)	3.62532890
14	Renal Fanconi syndrome (HP:0001994)	3.60291855
15	3-Methylglutaconic aciduria (HP:0003535)	3.57061688
16	Adactyly (HP:0009776)	3.49970983
17	Increased muscle lipid content (HP:0009058)	3.30036013
18	Abnormality of the labia minora (HP:0012880)	3.27599054
19	Methylmalonic acidemia (HP:0002912)	3.20964235
20	Hepatocellular necrosis (HP:0001404)	3.17294450
21	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	3.16300623
22	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.05273551
23	Type I transferrin isoform profile (HP:0003642)	3.03820598
24	Hepatic necrosis (HP:0002605)	2.95222940
25	Cerebral edema (HP:0002181)	2.93013822
26	Attenuation of retinal blood vessels (HP:0007843)	2.90011746
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.85295042
28	Increased serum lactate (HP:0002151)	2.80042104
29	Absent thumb (HP:0009777)	2.78059464
30	Hypoplasia of the pons (HP:0012110)	2.70738021
31	Exertional dyspnea (HP:0002875)	2.66010664
32	Hyperglycinemia (HP:0002154)	2.61545748
33	Optic disc pallor (HP:0000543)	2.58781559
34	Lactic acidosis (HP:0003128)	2.57933296
35	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.54604155
36	Abolished electroretinogram (ERG) (HP:0000550)	2.53686237
37	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.50656040
38	Abnormal protein N-linked glycosylation (HP:0012347)	2.50656040
39	Abnormal protein glycosylation (HP:0012346)	2.50656040
40	Abnormal glycosylation (HP:0012345)	2.50656040
41	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.48586627
42	Abnormality of the pons (HP:0007361)	2.47495468
43	Methylmalonic aciduria (HP:0012120)	2.45641781
44	IgG deficiency (HP:0004315)	2.40108717
45	Colon cancer (HP:0003003)	2.39041394
46	Hyperphosphaturia (HP:0003109)	2.32222816
47	Broad alveolar ridges (HP:0000187)	2.31705025
48	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.30101929
49	Respiratory failure (HP:0002878)	2.28329016
50	Lethargy (HP:0001254)	2.28262352
51	Asplenia (HP:0001746)	2.26643018
52	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.24573031
53	Respiratory difficulties (HP:0002880)	2.24367267
54	Abnormality of serum amino acid levels (HP:0003112)	2.22079872
55	Pancreatic cysts (HP:0001737)	2.21895208
56	Abnormality of urine glucose concentration (HP:0011016)	2.19241841
57	Glycosuria (HP:0003076)	2.19241841
58	Panhypogammaglobulinemia (HP:0003139)	2.18428368
59	Visual hallucinations (HP:0002367)	2.18246329
60	Abnormality of renal resorption (HP:0011038)	2.16191832
61	Distal arthrogryposis (HP:0005684)	2.15548382
62	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.13827969
63	Stomatitis (HP:0010280)	2.10755671
64	Pendular nystagmus (HP:0012043)	2.10324701
65	Reduced antithrombin III activity (HP:0001976)	2.10092459
66	Aplasia/hypoplasia of the uterus (HP:0008684)	2.10024418
67	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.08367913
68	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.08367913
69	True hermaphroditism (HP:0010459)	2.06201632
70	Sclerocornea (HP:0000647)	2.00835831
71	Abnormality of the distal phalanges of the toes (HP:0010182)	1.99943555
72	Leukodystrophy (HP:0002415)	1.98960144
73	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.98943359
74	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.98884624
75	Absent/shortened dynein arms (HP:0200106)	1.98884624
76	Increased serum pyruvate (HP:0003542)	1.98682072
77	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.97668842
78	Short tibia (HP:0005736)	1.97099278
79	Exercise intolerance (HP:0003546)	1.96048523
80	Pancreatic fibrosis (HP:0100732)	1.95872966
81	Abnormality of the middle phalanges of the toes (HP:0010183)	1.94617700
82	Nephronophthisis (HP:0000090)	1.92759177
83	Hypoplasia of the uterus (HP:0000013)	1.89610269
84	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.89218773
85	Anencephaly (HP:0002323)	1.88908054
86	Thyroid-stimulating hormone excess (HP:0002925)	1.88844100
87	Hypomagnesemia (HP:0002917)	1.81688607
88	Bile duct proliferation (HP:0001408)	1.81154451
89	Abnormal biliary tract physiology (HP:0012439)	1.81154451
90	Abnormality of vitamin B metabolism (HP:0004340)	1.80382429
91	CNS demyelination (HP:0007305)	1.78613232
92	Dyskinesia (HP:0100660)	1.78094984
93	Hypoproteinemia (HP:0003075)	1.77735255
94	Molar tooth sign on MRI (HP:0002419)	1.77615990
95	Abnormality of midbrain morphology (HP:0002418)	1.77615990
96	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.75538808
97	Congenital, generalized hypertrichosis (HP:0004540)	1.75517252
98	Renal cortical cysts (HP:0000803)	1.75311311
99	Constricted visual fields (HP:0001133)	1.74712144
100	Cerebral hypomyelination (HP:0006808)	1.74616491

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	6.11279557
2	PBK	4.06908537
3	ZAK	3.94726063
4	TLK1	3.28964690
5	ACVR1B	3.06142490
6	INSRR	2.85530798
7	NUAK1	2.79287182
8	BUB1	2.74466762
9	TSSK6	2.54312059
10	MST4	2.45930816
11	MKNK1	2.28774696
12	BCKDK	2.24797176
13	VRK2	2.18347566
14	ADRBK2	1.99393326
15	SRPK1	1.96974557
16	EIF2AK3	1.69934095
17	CDC7	1.68344469
18	TAF1	1.66046061
19	WNK3	1.58677797
20	STK38L	1.50788484
21	VRK1	1.50683513
22	STK16	1.48157900
23	GRK1	1.30764210
24	TXK	1.26344289
25	PLK3	1.24298122
26	NEK1	1.19287748
27	CSNK1G2	1.16232679
28	NME2	1.15068217
29	WNK4	1.14990813
30	MAPKAPK5	1.14585102
31	EIF2AK1	1.13767169
32	EIF2AK2	1.06512938
33	RPS6KA5	1.04855721
34	FRK	1.01570166
35	STK24	1.01449829
36	ITK	0.98804672
37	ATR	0.96590690
38	MUSK	0.95287790
39	TEC	0.94174404
40	PINK1	0.90945787
41	ERBB3	0.89886038
42	TNIK	0.89861804
43	STK4	0.88003585
44	OXSR1	0.85342265
45	CSNK1G1	0.82842794
46	CSNK1G3	0.82142709
47	SCYL2	0.80005366
48	NME1	0.79060732
49	PLK1	0.77414371
50	PHKG1	0.76033759
51	PHKG2	0.76033759
52	DAPK1	0.75207942
53	TAOK3	0.67886827
54	DYRK2	0.65710425
55	PAK4	0.65660817
56	MAP2K2	0.62228478
57	CSNK1A1L	0.61735319
58	STK39	0.61237729
59	PDK2	0.60116131
60	TRIM28	0.57086492
61	BRD4	0.56648172
62	ALK	0.48342889
63	AURKB	0.47811994
64	MKNK2	0.47180160
65	PRKCQ	0.45589579
66	PIM1	0.45447007
67	MAP3K4	0.44538855
68	OBSCN	0.44071073
69	ATM	0.40948544
70	CHEK2	0.40629476
71	MAP2K6	0.40214088
72	DAPK2	0.39727252
73	CSNK2A1	0.39514820
74	RPS6KA4	0.38214823
75	CSNK2A2	0.37632108
76	KDR	0.37391809
77	CDK19	0.37068669
78	TIE1	0.36692964
79	BTK	0.36561199
80	BMPR1B	0.36171357
81	IKBKB	0.36093726
82	DAPK3	0.35916559
83	CSNK1A1	0.35132591
84	PLK4	0.34098934
85	MAP3K8	0.32008956
86	CSNK1E	0.31561520
87	CAMK2A	0.29922614
88	IGF1R	0.26720952
89	AURKA	0.25468471
90	CHEK1	0.24653535
91	MAP3K13	0.24025330
92	SYK	0.23686742
93	EGFR	0.22623001
94	ADRBK1	0.22577548
95	IRAK1	0.22067692
96	TTK	0.21669012
97	BCR	0.21131252
98	PRKCG	0.20849989
99	MYLK	0.20468808
100	MAPK13	0.19737945

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.28456568
2	RNA polymerase_Homo sapiens_hsa03020	3.01494895
3	One carbon pool by folate_Homo sapiens_hsa00670	2.97631894
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.77841009
5	Asthma_Homo sapiens_hsa05310	2.50254524
6	Ribosome_Homo sapiens_hsa03010	2.40724352
7	Allograft rejection_Homo sapiens_hsa05330	2.38401073
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.38259235
9	Base excision repair_Homo sapiens_hsa03410	2.34733671
10	DNA replication_Homo sapiens_hsa03030	2.24598470
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.24452727
12	Sulfur metabolism_Homo sapiens_hsa00920	2.13569582
13	Mismatch repair_Homo sapiens_hsa03430	2.10926784
14	Parkinsons disease_Homo sapiens_hsa05012	2.10818149
15	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.03545256
16	Protein export_Homo sapiens_hsa03060	2.00247374
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.95991641
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.93997112
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.89239478
20	Propanoate metabolism_Homo sapiens_hsa00640	1.70376236
21	Homologous recombination_Homo sapiens_hsa03440	1.70280491
22	Basal transcription factors_Homo sapiens_hsa03022	1.68975797
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.68876785
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.68356574
25	RNA degradation_Homo sapiens_hsa03018	1.49366915
26	Phototransduction_Homo sapiens_hsa04744	1.47841142
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.47132992
28	Type I diabetes mellitus_Homo sapiens_hsa04940	1.46644065
29	Primary immunodeficiency_Homo sapiens_hsa05340	1.46360240
30	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.42709722
31	Graft-versus-host disease_Homo sapiens_hsa05332	1.38674877
32	Spliceosome_Homo sapiens_hsa03040	1.37020204
33	Huntingtons disease_Homo sapiens_hsa05016	1.36075649
34	Purine metabolism_Homo sapiens_hsa00230	1.30570371
35	Non-homologous end-joining_Homo sapiens_hsa03450	1.29065618
36	RNA transport_Homo sapiens_hsa03013	1.28168317
37	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.26151018
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.23783002
39	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.23038704
40	Alzheimers disease_Homo sapiens_hsa05010	1.22121787
41	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.20384899
42	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.14844325
43	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.11301391
44	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.08977667
45	Linoleic acid metabolism_Homo sapiens_hsa00591	1.08319287
46	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.08028543
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.04355981
48	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.01219487
49	Peroxisome_Homo sapiens_hsa04146	1.00140823
50	Fatty acid elongation_Homo sapiens_hsa00062	0.96116795
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.94185430
52	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.88679799
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86053218
54	Caffeine metabolism_Homo sapiens_hsa00232	0.84589681
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83132718
56	Pyruvate metabolism_Homo sapiens_hsa00620	0.81699993
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.81592121
58	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.80642199
59	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.78881759
60	Cardiac muscle contraction_Homo sapiens_hsa04260	0.78766074
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.78314318
62	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.77263769
63	Steroid biosynthesis_Homo sapiens_hsa00100	0.76562782
64	Antigen processing and presentation_Homo sapiens_hsa04612	0.75665197
65	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.75632151
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.72888948
67	Selenocompound metabolism_Homo sapiens_hsa00450	0.72583982
68	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.71457684
69	Metabolic pathways_Homo sapiens_hsa01100	0.70654677
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66165110
71	Glutathione metabolism_Homo sapiens_hsa00480	0.62024825
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.61517508
73	Fatty acid metabolism_Homo sapiens_hsa01212	0.55080651
74	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.54900518
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.54102147
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51075775
77	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.50689772
78	Butanoate metabolism_Homo sapiens_hsa00650	0.48178387
79	Retinol metabolism_Homo sapiens_hsa00830	0.43896511
80	Olfactory transduction_Homo sapiens_hsa04740	0.43127415
81	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.43116584
82	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.42575355
83	Arginine and proline metabolism_Homo sapiens_hsa00330	0.42067365
84	Carbon metabolism_Homo sapiens_hsa01200	0.41261337
85	Taste transduction_Homo sapiens_hsa04742	0.38738739
86	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.36216164
87	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.35934447
88	Ether lipid metabolism_Homo sapiens_hsa00565	0.35828010
89	Mineral absorption_Homo sapiens_hsa04978	0.34346177
90	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.34213615
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34072200
92	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.34050042
93	Rheumatoid arthritis_Homo sapiens_hsa05323	0.33796332
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33418162
95	Fat digestion and absorption_Homo sapiens_hsa04975	0.32717059
96	ABC transporters_Homo sapiens_hsa02010	0.32672245
97	Collecting duct acid secretion_Homo sapiens_hsa04966	0.32105099
98	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.31852978
99	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.30498451
100	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.28859493

HNRNPA1P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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