ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.95019528
2	sequestering of actin monomers (GO:0042989)	4.83917923
3	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.64062965
4	protein neddylation (GO:0045116)	4.41355055
5	cytidine metabolic process (GO:0046087)	4.37565031
6	cytidine catabolic process (GO:0006216)	4.37565031
7	cytidine deamination (GO:0009972)	4.37565031
8	platelet dense granule organization (GO:0060155)	3.85537573
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.77910735
10	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.77630588
11	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.76504630
12	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.66786028
13	ATP synthesis coupled proton transport (GO:0015986)	3.66786028
14	GPI anchor metabolic process (GO:0006505)	3.63202865
15	proteasome assembly (GO:0043248)	3.60079781
16	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.47903018
17	GPI anchor biosynthetic process (GO:0006506)	3.44530673
18	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.43493097
19	response to pheromone (GO:0019236)	3.42851924
20	base-excision repair, AP site formation (GO:0006285)	3.40080740
21	protein complex biogenesis (GO:0070271)	3.37338937
22	mannosylation (GO:0097502)	3.35824638
23	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.31062064
24	preassembly of GPI anchor in ER membrane (GO:0016254)	3.30588584
25	iron-sulfur cluster assembly (GO:0016226)	3.29274425
26	metallo-sulfur cluster assembly (GO:0031163)	3.29274425
27	purine deoxyribonucleotide catabolic process (GO:0009155)	3.28942760
28	ribosomal small subunit assembly (GO:0000028)	3.26639354
29	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.25715177
30	actin nucleation (GO:0045010)	3.22750722
31	regulation of cellular amino acid metabolic process (GO:0006521)	3.15895381
32	respiratory electron transport chain (GO:0022904)	3.12630297
33	electron transport chain (GO:0022900)	3.12556928
34	respiratory chain complex IV assembly (GO:0008535)	3.10533807
35	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.09659139
36	cytochrome complex assembly (GO:0017004)	3.09254867
37	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.08494513
38	behavioral response to nicotine (GO:0035095)	3.06794162
39	water-soluble vitamin biosynthetic process (GO:0042364)	3.06178710
40	mitochondrial respiratory chain complex assembly (GO:0033108)	3.05373100
41	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.03480032
42	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.99094393
43	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.99094393
44	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.98485623
45	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.98485623
46	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.98485623
47	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.96131802
48	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.96131802
49	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.94445744
50	negative regulation by host of viral transcription (GO:0043922)	2.89109065
51	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.87273790
52	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.84348261
53	deoxyribonucleotide catabolic process (GO:0009264)	2.83653853
54	deoxyribose phosphate catabolic process (GO:0046386)	2.82283718
55	negative T cell selection (GO:0043383)	2.81008369
56	purine deoxyribonucleotide metabolic process (GO:0009151)	2.79218124
57	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.77951363
58	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.77951363
59	NADH dehydrogenase complex assembly (GO:0010257)	2.77951363
60	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.77284230
61	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.77284230
62	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.76888696
63	chaperone-mediated protein transport (GO:0072321)	2.76860944
64	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.76544711
65	positive regulation of calcium-mediated signaling (GO:0050850)	2.73747592
66	neural tube formation (GO:0001841)	2.72621466
67	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.70160753
68	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.66207189
69	DNA double-strand break processing (GO:0000729)	2.64852603
70	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.64184043
71	negative regulation of mast cell activation (GO:0033004)	2.64049896
72	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.63886915
73	negative regulation of ligase activity (GO:0051352)	2.63480134
74	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.63480134
75	aggressive behavior (GO:0002118)	2.61225033
76	cytolysis (GO:0019835)	2.57974356
77	ubiquinone metabolic process (GO:0006743)	2.55934418
78	positive regulation of interleukin-8 secretion (GO:2000484)	2.55703505
79	sulfation (GO:0051923)	2.55371007
80	organelle disassembly (GO:1903008)	2.54191692
81	regulation of T cell receptor signaling pathway (GO:0050856)	2.53765799
82	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.53266004
83	rRNA modification (GO:0000154)	2.52797303
84	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.52504925
85	negative regulation of T cell apoptotic process (GO:0070233)	2.52294043
86	2-deoxyribonucleotide metabolic process (GO:0009394)	2.51452781
87	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.49819645
88	indole-containing compound catabolic process (GO:0042436)	2.47884190
89	indolalkylamine catabolic process (GO:0046218)	2.47884190
90	tryptophan catabolic process (GO:0006569)	2.47884190
91	deoxyribose phosphate metabolic process (GO:0019692)	2.47384142
92	kynurenine metabolic process (GO:0070189)	2.46889192
93	regulation of interleukin-8 secretion (GO:2000482)	2.46730464
94	positive T cell selection (GO:0043368)	2.46127351
95	ubiquinone biosynthetic process (GO:0006744)	2.45336755
96	glycolipid biosynthetic process (GO:0009247)	2.43843801
97	adenosine metabolic process (GO:0046085)	2.43834396
98	T cell migration (GO:0072678)	2.42466010
99	DNA demethylation (GO:0080111)	2.40621810
100	S-adenosylmethionine metabolic process (GO:0046500)	2.40607766

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.54919527
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.50872062
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.49388298
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.18888483
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.09775530
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.07342499
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.98338354
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.86171950
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.84569921
10	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.79701081
11	VDR_22108803_ChIP-Seq_LS180_Human	2.77500034
12	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.71666006
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.50845005
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.43921159
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.29061507
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.16926755
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.12849623
18	EWS_26573619_Chip-Seq_HEK293_Human	2.05597892
19	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.01960399
20	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.00504904
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.97345877
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.94125131
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.89185978
24	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.87126851
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.83911988
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.80621989
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.76431902
28	FUS_26573619_Chip-Seq_HEK293_Human	1.73277995
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73158206
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.69511407
31	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.66710004
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.64672400
33	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.63177005
34	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.61014907
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55778146
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.55180499
37	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.53613900
38	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.52304718
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.52195143
40	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.50199258
41	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.45341173
42	P300_19829295_ChIP-Seq_ESCs_Human	1.44403530
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39630006
44	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.37436052
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.37291838
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.37291838
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33312275
48	AR_20517297_ChIP-Seq_VCAP_Human	1.31817511
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30830643
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30830643
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29933505
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.29933505
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29365491
54	MYB_26560356_Chip-Seq_TH2_Human	1.28689234
55	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.27950014
56	GATA3_26560356_Chip-Seq_TH2_Human	1.25273926
57	GBX2_23144817_ChIP-Seq_PC3_Human	1.22888012
58	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.22809695
59	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.22494322
60	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.21630719
61	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.20918802
62	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20900826
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.20620394
64	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.17376918
65	NCOR_22424771_ChIP-Seq_293T_Human	1.16815214
66	HTT_18923047_ChIP-ChIP_STHdh_Human	1.16326970
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16146074
68	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.16039361
69	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.14758744
70	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.14629884
71	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13708946
72	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.13539030
73	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11578313
74	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.10342231
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10006905
76	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.09808701
77	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.08601429
78	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.08459383
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08311008
80	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.07839111
81	ERG_20517297_ChIP-Seq_VCAP_Human	1.07299122
82	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.07160347
83	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05255201
84	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05075867
85	GATA3_27048872_Chip-Seq_THYMUS_Human	1.04888782
86	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04664261
87	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.04221648
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02398970
89	BCAT_22108803_ChIP-Seq_LS180_Human	0.99206494
90	NANOG_20526341_ChIP-Seq_ESCs_Human	0.98988937
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98079155
92	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.96358849
93	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.95136097
94	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.90424776
95	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.89920556
96	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89626413
97	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.89496637
98	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89357240
99	EZH2_22144423_ChIP-Seq_EOC_Human	0.89210973
100	TCF4_22108803_ChIP-Seq_LS180_Human	0.88902511

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.78190401
2	MP0002102_abnormal_ear_morphology	2.94414909
3	MP0006072_abnormal_retinal_apoptosis	2.76109017
4	MP0003880_abnormal_central_pattern	2.64870696
5	MP0000372_irregular_coat_pigmentation	2.46560327
6	MP0009785_altered_susceptibility_to	2.28362224
7	MP0004147_increased_porphyrin_level	2.26975553
8	MP0001835_abnormal_antigen_presentation	2.20697998
9	MP0008877_abnormal_DNA_methylation	2.15481296
10	MP0006292_abnormal_olfactory_placode	2.14969266
11	MP0003787_abnormal_imprinting	2.05348438
12	MP0008995_early_reproductive_senescence	2.05323665
13	MP0008058_abnormal_DNA_repair	2.02702468
14	MP0002234_abnormal_pharynx_morphology	1.95750372
15	MP0005645_abnormal_hypothalamus_physiol	1.94430523
16	MP0005646_abnormal_pituitary_gland	1.94419241
17	MP0005551_abnormal_eye_electrophysiolog	1.92775196
18	MP0003786_premature_aging	1.86641135
19	MP0005253_abnormal_eye_physiology	1.86015798
20	MP0008872_abnormal_physiological_respon	1.85661608
21	MP0010386_abnormal_urinary_bladder	1.80239858
22	MP0002166_altered_tumor_susceptibility	1.76864664
23	MP0006276_abnormal_autonomic_nervous	1.76780443
24	MP0003763_abnormal_thymus_physiology	1.72715240
25	MP0001764_abnormal_homeostasis	1.71774190
26	MP0003195_calcinosis	1.66672302
27	MP0005075_abnormal_melanosome_morpholog	1.57304565
28	MP0008875_abnormal_xenobiotic_pharmacok	1.54745142
29	MP0002006_tumorigenesis	1.50858650
30	MP0001968_abnormal_touch/_nociception	1.49332521
31	MP0005084_abnormal_gallbladder_morpholo	1.45035616
32	MP0003011_delayed_dark_adaptation	1.41803648
33	MP0004145_abnormal_muscle_electrophysio	1.41110651
34	MP0004885_abnormal_endolymph	1.40726343
35	MP0002148_abnormal_hypersensitivity_rea	1.37114712
36	MP0009697_abnormal_copulation	1.35163527
37	MP0001800_abnormal_humoral_immune	1.34352998
38	MP0003646_muscle_fatigue	1.34251604
39	MP0002837_dystrophic_cardiac_calcinosis	1.33700945
40	MP0003806_abnormal_nucleotide_metabolis	1.29747215
41	MP0002736_abnormal_nociception_after	1.27032075
42	MP0001905_abnormal_dopamine_level	1.25526150
43	MP0001529_abnormal_vocalization	1.23626649
44	MP0005000_abnormal_immune_tolerance	1.23521726
45	MP0008789_abnormal_olfactory_epithelium	1.23076294
46	MP0002420_abnormal_adaptive_immunity	1.21066307
47	MP0005387_immune_system_phenotype	1.20867537
48	MP0001790_abnormal_immune_system	1.20867537
49	MP0005025_abnormal_response_to	1.18503899
50	MP0000631_abnormal_neuroendocrine_gland	1.18373571
51	MP0004142_abnormal_muscle_tone	1.17984693
52	MP0002723_abnormal_immune_serum	1.17973606
53	MP0001819_abnormal_immune_cell	1.17588000
54	MP0003866_abnormal_defecation	1.14588824
55	MP0002638_abnormal_pupillary_reflex	1.13932943
56	MP0009379_abnormal_foot_pigmentation	1.12500369
57	MP0000685_abnormal_immune_system	1.12401552
58	MP0009333_abnormal_splenocyte_physiolog	1.08995888
59	MP0002277_abnormal_respiratory_mucosa	1.08796118
60	MP0003567_abnormal_fetal_cardiomyocyte	1.07163067
61	MP0001501_abnormal_sleep_pattern	1.06884803
62	MP0005389_reproductive_system_phenotype	1.04472955
63	MP0001919_abnormal_reproductive_system	1.03736725
64	MP0003137_abnormal_impulse_conducting	1.03000578
65	MP0002876_abnormal_thyroid_physiology	1.02231042
66	MP0002751_abnormal_autonomic_nervous	1.02170886
67	MP0006036_abnormal_mitochondrial_physio	1.01322729
68	MP0002160_abnormal_reproductive_system	1.00256126
69	MP0005085_abnormal_gallbladder_physiolo	0.98833684
70	MP0001986_abnormal_taste_sensitivity	0.97464456
71	MP0004043_abnormal_pH_regulation	0.96154033
72	MP0002452_abnormal_antigen_presenting	0.95888055
73	MP0000716_abnormal_immune_system	0.93977097
74	MP0009764_decreased_sensitivity_to	0.93093881
75	MP0004133_heterotaxia	0.88791430
76	MP0002398_abnormal_bone_marrow	0.88784747
77	MP0002095_abnormal_skin_pigmentation	0.88336566
78	MP0000689_abnormal_spleen_morphology	0.86323004
79	MP0001293_anophthalmia	0.85764151
80	MP0002272_abnormal_nervous_system	0.85204881
81	MP0003718_maternal_effect	0.85132778
82	MP0002822_catalepsy	0.84245867
83	MP0009745_abnormal_behavioral_response	0.81179516
84	MP0000647_abnormal_sebaceous_gland	0.80173267
85	MP0003252_abnormal_bile_duct	0.79906369
86	MP0005410_abnormal_fertilization	0.79441131
87	MP0002733_abnormal_thermal_nociception	0.79218484
88	MP0002163_abnormal_gland_morphology	0.78918850
89	MP0003724_increased_susceptibility_to	0.78574683
90	MP0001119_abnormal_female_reproductive	0.78515802
91	MP0006082_CNS_inflammation	0.78393697
92	MP0010094_abnormal_chromosome_stability	0.76639954
93	MP0001929_abnormal_gametogenesis	0.76402924
94	MP0000049_abnormal_middle_ear	0.76393020
95	MP0005083_abnormal_biliary_tract	0.74651142
96	MP0010155_abnormal_intestine_physiology	0.73877433
97	MP0002722_abnormal_immune_system	0.73763418
98	MP0001984_abnormal_olfaction	0.73651948
99	MP0000703_abnormal_thymus_morphology	0.73507371
100	MP0001188_hyperpigmentation	0.73110934

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Mitochondrial inheritance (HP:0001427)	3.72185833
2	Congenital stationary night blindness (HP:0007642)	3.65360737
3	Acute necrotizing encephalopathy (HP:0006965)	3.61732811
4	Increased hepatocellular lipid droplets (HP:0006565)	3.48995471
5	Aplastic anemia (HP:0001915)	3.46015285
6	IgG deficiency (HP:0004315)	3.38661768
7	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.35195371
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.32737062
9	Increased CSF lactate (HP:0002490)	3.32354047
10	Hepatocellular necrosis (HP:0001404)	3.27649521
11	Lipid accumulation in hepatocytes (HP:0006561)	3.25251023
12	Methylmalonic acidemia (HP:0002912)	3.24388389
13	3-Methylglutaconic aciduria (HP:0003535)	3.22214253
14	Severe combined immunodeficiency (HP:0004430)	3.18385423
15	Pancreatic cysts (HP:0001737)	3.17755973
16	Acute encephalopathy (HP:0006846)	3.15394914
17	True hermaphroditism (HP:0010459)	3.14708383
18	Hypoproteinemia (HP:0003075)	3.11587647
19	Progressive macrocephaly (HP:0004481)	3.00088316
20	Hepatic necrosis (HP:0002605)	2.97332750
21	Molar tooth sign on MRI (HP:0002419)	2.97010157
22	Abnormality of midbrain morphology (HP:0002418)	2.97010157
23	Renal Fanconi syndrome (HP:0001994)	2.95725041
24	Attenuation of retinal blood vessels (HP:0007843)	2.94622101
25	Pancreatic fibrosis (HP:0100732)	2.84330983
26	Increased intramyocellular lipid droplets (HP:0012240)	2.83782777
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.82309225
28	T lymphocytopenia (HP:0005403)	2.79701224
29	Abnormality of T cell number (HP:0011839)	2.78379919
30	Abolished electroretinogram (ERG) (HP:0000550)	2.72228918
31	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.68841240
32	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.68841240
33	Colon cancer (HP:0003003)	2.66956594
34	Nephronophthisis (HP:0000090)	2.65274007
35	Abnormality of B cell number (HP:0010975)	2.61284004
36	Hyperglycinemia (HP:0002154)	2.57595318
37	Thyroiditis (HP:0100646)	2.57455508
38	Increased IgM level (HP:0003496)	2.53063474
39	Methylmalonic aciduria (HP:0012120)	2.51840251
40	Abnormality of the prostate (HP:0008775)	2.51536024
41	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.50937645
42	Medial flaring of the eyebrow (HP:0010747)	2.50244926
43	Cerebral edema (HP:0002181)	2.47941756
44	Combined immunodeficiency (HP:0005387)	2.44457205
45	Optic disc pallor (HP:0000543)	2.41964277
46	Constricted visual fields (HP:0001133)	2.41310172
47	Abnormality of the renal cortex (HP:0011035)	2.38289731
48	Increased muscle lipid content (HP:0009058)	2.35451380
49	Renal cortical cysts (HP:0000803)	2.31091140
50	Decreased central vision (HP:0007663)	2.30799988
51	Exertional dyspnea (HP:0002875)	2.30145315
52	Lactic acidosis (HP:0003128)	2.26442777
53	Increased serum lactate (HP:0002151)	2.26440974
54	Stomatitis (HP:0010280)	2.25523444
55	Autoimmune hemolytic anemia (HP:0001890)	2.25225862
56	Pancytopenia (HP:0001876)	2.24239056
57	Abnormality of the renal medulla (HP:0100957)	2.16069879
58	Abnormality of eosinophils (HP:0001879)	2.15767475
59	B lymphocytopenia (HP:0010976)	2.15254500
60	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.14964953
61	Abnormality of T cells (HP:0002843)	2.14317692
62	Type 2 muscle fiber atrophy (HP:0003554)	2.12210685
63	Elevated erythrocyte sedimentation rate (HP:0003565)	2.08280807
64	Abnormality of alanine metabolism (HP:0010916)	2.04163939
65	Hyperalaninemia (HP:0003348)	2.04163939
66	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.04163939
67	Hypothermia (HP:0002045)	2.03864353
68	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.99856684
69	Lethargy (HP:0001254)	1.98113371
70	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.96298262
71	Abnormality of serum amino acid levels (HP:0003112)	1.95982454
72	Respiratory failure (HP:0002878)	1.95385926
73	Dicarboxylic aciduria (HP:0003215)	1.91639609
74	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.91639609
75	Abnormality of renal resorption (HP:0011038)	1.90469391
76	Type I transferrin isoform profile (HP:0003642)	1.87985397
77	Generalized aminoaciduria (HP:0002909)	1.86943975
78	Abnormality of vitamin B metabolism (HP:0004340)	1.83478987
79	Thyroid-stimulating hormone excess (HP:0002925)	1.81808582
80	Stomach cancer (HP:0012126)	1.81220446
81	Encephalitis (HP:0002383)	1.80482018
82	Pendular nystagmus (HP:0012043)	1.80069441
83	Congenital primary aphakia (HP:0007707)	1.79215108
84	Amyotrophic lateral sclerosis (HP:0007354)	1.78441457
85	Abnormality of DNA repair (HP:0003254)	1.78403090
86	Sclerocornea (HP:0000647)	1.78283780
87	Abnormality of serine family amino acid metabolism (HP:0010894)	1.78093832
88	Abnormality of glycine metabolism (HP:0010895)	1.78093832
89	Autoimmune thrombocytopenia (HP:0001973)	1.77546531
90	Aplasia/hypoplasia of the uterus (HP:0008684)	1.75807272
91	Postaxial foot polydactyly (HP:0001830)	1.75061952
92	Nephrogenic diabetes insipidus (HP:0009806)	1.74282032
93	Eosinophilia (HP:0001880)	1.73676701
94	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.72420178
95	Panhypogammaglobulinemia (HP:0003139)	1.71544370
96	Cystic liver disease (HP:0006706)	1.71027249
97	Chronic hepatic failure (HP:0100626)	1.70709132
98	Exercise intolerance (HP:0003546)	1.70571639
99	Short tibia (HP:0005736)	1.70251739
100	Abnormal respiratory epithelium morphology (HP:0012253)	1.69986244

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	3.89548103
2	MAP4K2	3.61357304
3	KDR	3.37276057
4	VRK2	3.20095529
5	TXK	3.00125314
6	ZAK	2.83263176
7	TAOK3	2.43686008
8	PINK1	2.41378983
9	BCKDK	2.27289448
10	ADRBK2	2.26238397
11	NUAK1	2.22524276
12	VRK1	2.21220509
13	TLK1	2.20440908
14	GRK1	2.11346802
15	ERBB3	1.89900826
16	WNK3	1.55501279
17	PASK	1.54747687
18	BCR	1.53885624
19	ITK	1.51304032
20	FRK	1.50200673
21	MAP4K1	1.48045993
22	BUB1	1.38020560
23	TRIM28	1.37468980
24	MKNK1	1.33613334
25	MUSK	1.33293321
26	EIF2AK3	1.28696477
27	CSNK1G3	1.26573424
28	CAMKK2	1.25809722
29	LIMK1	1.18723406
30	TEC	1.17749308
31	MAP3K12	1.11376665
32	MAPK13	1.10286539
33	MST4	1.07953257
34	WNK4	1.06120355
35	BMPR1B	1.06027391
36	CSNK1G2	1.04692644
37	TESK1	1.00151197
38	MAP2K7	0.99578678
39	CSNK1G1	0.99422600
40	MAP3K4	0.99340153
41	NME1	0.95449445
42	STK16	0.95309045
43	CDK19	0.94881622
44	SYK	0.93641202
45	CSNK1A1L	0.92215298
46	CCNB1	0.90796983
47	INSRR	0.89018357
48	TAF1	0.87025021
49	SRPK1	0.82040847
50	KIT	0.79597177
51	DAPK1	0.78931662
52	PRKCQ	0.76131970
53	CSF1R	0.75193935
54	DYRK2	0.74641893
55	TIE1	0.73222404
56	MAPKAPK3	0.72222466
57	IKBKE	0.69956942
58	FLT3	0.69302781
59	RPS6KA4	0.68256595
60	PLK3	0.67887556
61	TNK2	0.67084542
62	BTK	0.65359280
63	NEK1	0.62815326
64	RPS6KA5	0.59641646
65	SCYL2	0.59561667
66	EPHA4	0.59369342
67	PLK4	0.59246385
68	IKBKB	0.58941572
69	CDC7	0.57955946
70	OXSR1	0.57207159
71	LCK	0.56752808
72	GRK6	0.56232212
73	LYN	0.53886709
74	ADRBK1	0.52512240
75	MYLK	0.52408015
76	MAPKAPK5	0.52162595
77	FES	0.50988194
78	PIK3CG	0.48255039
79	DAPK2	0.48245019
80	MATK	0.46754124
81	CSNK2A1	0.45803554
82	PRKCE	0.44835040
83	OBSCN	0.44451637
84	IGF1R	0.44101449
85	GRK7	0.43791209
86	CAMKK1	0.41954295
87	ATR	0.41581880
88	ACVR1B	0.40759121
89	EIF2AK2	0.39335306
90	EPHA3	0.38571568
91	PBK	0.37933664
92	CSNK1A1	0.37848347
93	PLK2	0.37379145
94	AURKB	0.37066313
95	CAMK2A	0.35158736
96	STK39	0.34346570
97	PRKACA	0.33967765
98	PRKCA	0.32835312
99	TRPM7	0.31649804
100	NEK2	0.31627547

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.12190296
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.49244418
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.33416230
4	Protein export_Homo sapiens_hsa03060	2.96611414
5	Parkinsons disease_Homo sapiens_hsa05012	2.82435392
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.56268239
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.34899780
8	Ribosome_Homo sapiens_hsa03010	2.24362947
9	Phototransduction_Homo sapiens_hsa04744	2.09081045
10	RNA polymerase_Homo sapiens_hsa03020	1.94133091
11	Homologous recombination_Homo sapiens_hsa03440	1.90292752
12	Allograft rejection_Homo sapiens_hsa05330	1.83314827
13	Antigen processing and presentation_Homo sapiens_hsa04612	1.82093700
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.80842753
15	Graft-versus-host disease_Homo sapiens_hsa05332	1.80547266
16	Asthma_Homo sapiens_hsa05310	1.72124804
17	Basal transcription factors_Homo sapiens_hsa03022	1.71423161
18	Huntingtons disease_Homo sapiens_hsa05016	1.69802854
19	Alzheimers disease_Homo sapiens_hsa05010	1.65395198
20	Propanoate metabolism_Homo sapiens_hsa00640	1.62389145
21	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.58086967
22	Type I diabetes mellitus_Homo sapiens_hsa04940	1.55257880
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.53393868
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.51969119
25	RNA degradation_Homo sapiens_hsa03018	1.51475893
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.44919108
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.39292382
28	Base excision repair_Homo sapiens_hsa03410	1.36890618
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.35876461
30	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.31577386
31	Nucleotide excision repair_Homo sapiens_hsa03420	1.29615769
32	Butanoate metabolism_Homo sapiens_hsa00650	1.27023327
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.26372472
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.23897211
35	Spliceosome_Homo sapiens_hsa03040	1.19857882
36	Mismatch repair_Homo sapiens_hsa03430	1.18443288
37	DNA replication_Homo sapiens_hsa03030	1.17280291
38	Peroxisome_Homo sapiens_hsa04146	1.15671707
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.14493215
40	Cardiac muscle contraction_Homo sapiens_hsa04260	1.13533848
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.04302642
42	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.00813145
43	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.00752586
44	RNA transport_Homo sapiens_hsa03013	0.98590020
45	One carbon pool by folate_Homo sapiens_hsa00670	0.97937526
46	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.97839094
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.96342545
48	Non-homologous end-joining_Homo sapiens_hsa03450	0.95493506
49	Purine metabolism_Homo sapiens_hsa00230	0.95099439
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.90235812
51	Rheumatoid arthritis_Homo sapiens_hsa05323	0.89799438
52	Caffeine metabolism_Homo sapiens_hsa00232	0.89372395
53	Taste transduction_Homo sapiens_hsa04742	0.87387446
54	Olfactory transduction_Homo sapiens_hsa04740	0.86196787
55	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84868011
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80620410
57	Retinol metabolism_Homo sapiens_hsa00830	0.80355843
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.79540695
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79310078
60	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.79236920
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.79029514
62	Nicotine addiction_Homo sapiens_hsa05033	0.78034450
63	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74530878
64	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.72859869
65	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.72437375
66	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.71817874
67	Sulfur metabolism_Homo sapiens_hsa00920	0.69487566
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.68550795
69	Regulation of autophagy_Homo sapiens_hsa04140	0.68537233
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67519130
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66153014
72	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.65712087
73	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.64764663
74	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.62613380
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62134290
76	Metabolic pathways_Homo sapiens_hsa01100	0.61332524
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60199435
78	Ether lipid metabolism_Homo sapiens_hsa00565	0.59627605
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59197893
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.58928743
81	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.54749496
82	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.51416635
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.48349583
84	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47994789
85	Selenocompound metabolism_Homo sapiens_hsa00450	0.47134670
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45675478
87	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44396319
88	Glutathione metabolism_Homo sapiens_hsa00480	0.43435721
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42875722
90	Viral myocarditis_Homo sapiens_hsa05416	0.42618044
91	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.41214554
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.38721492
93	Collecting duct acid secretion_Homo sapiens_hsa04966	0.37979887
94	Fatty acid elongation_Homo sapiens_hsa00062	0.35495708
95	Morphine addiction_Homo sapiens_hsa05032	0.32708977
96	Fatty acid degradation_Homo sapiens_hsa00071	0.32423630
97	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.30410804
98	Salivary secretion_Homo sapiens_hsa04970	0.29949904
99	Measles_Homo sapiens_hsa05162	0.26377579
100	Herpes simplex infection_Homo sapiens_hsa05168	0.26275067

HNRNPA1P12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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