ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	7.44293463
2	chaperone-mediated protein transport (GO:0072321)	5.32849589
3	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.21224749
4	sulfation (GO:0051923)	4.89736430
5	protein polyglutamylation (GO:0018095)	4.34527447
6	preassembly of GPI anchor in ER membrane (GO:0016254)	4.26088853
7	positive regulation of prostaglandin secretion (GO:0032308)	3.96170607
8	positive regulation of transcription regulatory region DNA binding (GO:2000679)	3.88916910
9	regulation of immunoglobulin secretion (GO:0051023)	3.84331383
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.82965708
11	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.82965708
12	NADH dehydrogenase complex assembly (GO:0010257)	3.82965708
13	cytidine metabolic process (GO:0046087)	3.78372788
14	cytidine catabolic process (GO:0006216)	3.78372788
15	cytidine deamination (GO:0009972)	3.78372788
16	water-soluble vitamin biosynthetic process (GO:0042364)	3.72101910
17	regulation of DNA endoreduplication (GO:0032875)	3.65732549
18	activated T cell proliferation (GO:0050798)	3.65206617
19	positive regulation of granulocyte differentiation (GO:0030854)	3.55304648
20	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.51518531
21	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.51518531
22	protein complex biogenesis (GO:0070271)	3.50833420
23	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.47415425
24	mannosylation (GO:0097502)	3.44520836
25	response to lipoprotein particle (GO:0055094)	3.41756864
26	maturation of 5.8S rRNA (GO:0000460)	3.40482942
27	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.37029922
28	branched-chain amino acid catabolic process (GO:0009083)	3.34935530
29	mitochondrial respiratory chain complex assembly (GO:0033108)	3.34435497
30	regulation of prostaglandin secretion (GO:0032306)	3.23926769
31	replication fork processing (GO:0031297)	3.20994177
32	respiratory chain complex IV assembly (GO:0008535)	3.14261821
33	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.11234016
34	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.08428431
35	termination of RNA polymerase III transcription (GO:0006386)	3.08023483
36	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.08023483
37	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.06509227
38	protein deneddylation (GO:0000338)	3.03300203
39	one-carbon compound transport (GO:0019755)	3.02368651
40	behavioral response to nicotine (GO:0035095)	3.00343033
41	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.98296353
42	C-terminal protein lipidation (GO:0006501)	2.97473956
43	mechanosensory behavior (GO:0007638)	2.96058130
44	negative regulation of Rho protein signal transduction (GO:0035024)	2.93062490
45	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.91938222
46	C-terminal protein amino acid modification (GO:0018410)	2.90885340
47	amyloid precursor protein catabolic process (GO:0042987)	2.90452522
48	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.89135875
49	resolution of meiotic recombination intermediates (GO:0000712)	2.84716743
50	signal peptide processing (GO:0006465)	2.84014382
51	mismatch repair (GO:0006298)	2.83073266
52	cellular ketone body metabolic process (GO:0046950)	2.81097040
53	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.78690834
54	7-methylguanosine mRNA capping (GO:0006370)	2.78520081
55	cytochrome complex assembly (GO:0017004)	2.77018276
56	GPI anchor biosynthetic process (GO:0006506)	2.75581248
57	response to xenobiotic stimulus (GO:0009410)	2.74593057
58	positive regulation of cell fate commitment (GO:0010455)	2.74311574
59	GDP-mannose metabolic process (GO:0019673)	2.74220891
60	protein-cofactor linkage (GO:0018065)	2.71092651
61	RNA capping (GO:0036260)	2.70873687
62	7-methylguanosine RNA capping (GO:0009452)	2.70873687
63	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.70797352
64	regulation of chronic inflammatory response (GO:0002676)	2.70684043
65	regulation of mitotic spindle checkpoint (GO:1903504)	2.68871774
66	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.68871774
67	artery smooth muscle contraction (GO:0014824)	2.68662531
68	ribosomal small subunit assembly (GO:0000028)	2.68509993
69	regulation of fever generation (GO:0031620)	2.68056393
70	positive regulation of osteoclast differentiation (GO:0045672)	2.67731360
71	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	2.66505468
72	rRNA catabolic process (GO:0016075)	2.65362357
73	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.63789580
74	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.63761923
75	GPI anchor metabolic process (GO:0006505)	2.63708127
76	cellular response to exogenous dsRNA (GO:0071360)	2.63179632
77	detection of light stimulus involved in sensory perception (GO:0050962)	2.61802252
78	detection of light stimulus involved in visual perception (GO:0050908)	2.61802252
79	mitochondrial RNA metabolic process (GO:0000959)	2.60716116
80	phospholipid homeostasis (GO:0055091)	2.60464038
81	DNA double-strand break processing (GO:0000729)	2.59456154
82	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.58874686
83	UMP biosynthetic process (GO:0006222)	2.57361002
84	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	2.57361002
85	UMP metabolic process (GO:0046049)	2.57361002
86	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	2.57361002
87	ketone body metabolic process (GO:1902224)	2.56807442
88	tRNA processing (GO:0008033)	2.56364189
89	lysine catabolic process (GO:0006554)	2.55314527
90	lysine metabolic process (GO:0006553)	2.55314527
91	folic acid-containing compound biosynthetic process (GO:0009396)	2.53943129
92	proteasome assembly (GO:0043248)	2.52796221
93	tetrahydrofolate metabolic process (GO:0046653)	2.52599633
94	cytokine biosynthetic process (GO:0042089)	2.52400541
95	righting reflex (GO:0060013)	2.50971311
96	interleukin-1-mediated signaling pathway (GO:0070498)	2.49822431
97	response to methylmercury (GO:0051597)	2.49435256
98	DNA strand renaturation (GO:0000733)	2.49256147
99	RNA phosphodiester bond hydrolysis (GO:0090501)	2.48813584
100	reflex (GO:0060004)	2.48491287

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.03419876
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.16350504
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.42582492
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.38071872
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.35474473
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.28636530
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.23631125
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.66473174
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.64221582
10	VDR_22108803_ChIP-Seq_LS180_Human	2.63407858
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.54603807
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.44023553
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.37557922
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.34798500
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.16411531
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.10232493
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.05240049
18	GBX2_23144817_ChIP-Seq_PC3_Human	2.04827017
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.01021104
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.99412821
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.97997814
22	EWS_26573619_Chip-Seq_HEK293_Human	1.94418855
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.94329472
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.93315455
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.92596623
26	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.84665794
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.84631737
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.77706713
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.76387098
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.74925854
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.73741715
32	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.73129190
33	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.65293206
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.65257050
35	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.64952205
36	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.61335780
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55405841
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.54688497
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.54053747
40	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.50185093
41	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.49355438
42	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.43985654
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41517348
44	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.38373591
45	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38338978
46	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.31347825
47	P300_19829295_ChIP-Seq_ESCs_Human	1.30935923
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.28990662
49	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.23978505
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.23172504
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23172504
52	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.22454024
53	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.21195115
54	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.19560795
55	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18518059
56	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.16036130
57	FUS_26573619_Chip-Seq_HEK293_Human	1.14232784
58	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13061420
59	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.11209239
60	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10041401
61	GATA3_26560356_Chip-Seq_TH2_Human	1.09207570
62	TTF2_22483619_ChIP-Seq_HELA_Human	1.08232085
63	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.07698892
64	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.07371963
65	XRN2_22483619_ChIP-Seq_HELA_Human	1.06435712
66	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.05961146
67	TP53_22573176_ChIP-Seq_HFKS_Human	1.02989041
68	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.02808863
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02369871
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02369871
71	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.99895264
72	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.99805380
73	BCAT_22108803_ChIP-Seq_LS180_Human	0.98755896
74	ERG_20517297_ChIP-Seq_VCAP_Human	0.98428406
75	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.97224430
76	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.97055583
77	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97023718
78	TCF4_22108803_ChIP-Seq_LS180_Human	0.95478890
79	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.95210306
80	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.95146244
81	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.94218531
82	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.93624766
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.92492110
84	P300_18555785_Chip-Seq_ESCs_Mouse	0.91667125
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.86232015
86	CIITA_25753668_ChIP-Seq_RAJI_Human	0.85435693
87	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.84969068
88	AR_20517297_ChIP-Seq_VCAP_Human	0.84948614
89	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.84858850
90	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.84858850
91	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.83282553
92	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.82401712
93	GABP_19822575_ChIP-Seq_HepG2_Human	0.82062812
94	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.81175311
95	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.81118016
96	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.81083773
97	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.81011390
98	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.80777914
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.80690910
100	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.80422178

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.61151673
2	MP0002138_abnormal_hepatobiliary_system	3.37140376
3	MP0001873_stomach_inflammation	3.33738608
4	MP0008877_abnormal_DNA_methylation	3.29500705
5	MP0006072_abnormal_retinal_apoptosis	2.94413602
6	MP0005671_abnormal_response_to	2.84897380
7	MP0002254_reproductive_system_inflammat	2.81723265
8	MP0001348_abnormal_lacrimal_gland	2.76359526
9	MP0008875_abnormal_xenobiotic_pharmacok	2.76335194
10	MP0001529_abnormal_vocalization	2.70792042
11	MP0001986_abnormal_taste_sensitivity	2.64448185
12	MP0000569_abnormal_digit_pigmentation	2.50932782
13	MP0004885_abnormal_endolymph	2.27457846
14	MP0004782_abnormal_surfactant_physiolog	2.18607165
15	MP0003436_decreased_susceptibility_to	2.10656565
16	MP0003191_abnormal_cellular_cholesterol	2.10054106
17	MP0000685_abnormal_immune_system	2.08717346
18	MP0008872_abnormal_physiological_respon	1.97918976
19	MP0001188_hyperpigmentation	1.84270089
20	MP0000613_abnormal_salivary_gland	1.83938959
21	MP0008058_abnormal_DNA_repair	1.80891312
22	MP0005551_abnormal_eye_electrophysiolog	1.64152971
23	MP0005253_abnormal_eye_physiology	1.59834180
24	MP0006292_abnormal_olfactory_placode	1.51796667
25	MP0001919_abnormal_reproductive_system	1.49492248
26	MP0009840_abnormal_foam_cell	1.45634113
27	MP0008995_early_reproductive_senescence	1.44411308
28	MP0005389_reproductive_system_phenotype	1.43199883
29	MP0002148_abnormal_hypersensitivity_rea	1.42741057
30	MP0005174_abnormal_tail_pigmentation	1.42346383
31	MP0001968_abnormal_touch/_nociception	1.42205217
32	MP0001905_abnormal_dopamine_level	1.40223274
33	MP0001485_abnormal_pinna_reflex	1.39964454
34	MP0001835_abnormal_antigen_presentation	1.38583021
35	MP0003011_delayed_dark_adaptation	1.38395830
36	MP0001486_abnormal_startle_reflex	1.33357178
37	MP0005000_abnormal_immune_tolerance	1.29852314
38	MP0008007_abnormal_cellular_replicative	1.29403056
39	MP0006082_CNS_inflammation	1.29137583
40	MP0004742_abnormal_vestibular_system	1.26197769
41	MP0009764_decreased_sensitivity_to	1.26115533
42	MP0000372_irregular_coat_pigmentation	1.25968382
43	MP0002405_respiratory_system_inflammati	1.22650107
44	MP0001984_abnormal_olfaction	1.17868807
45	MP0002938_white_spotting	1.17810039
46	MP0001800_abnormal_humoral_immune	1.16594423
47	MP0010094_abnormal_chromosome_stability	1.16454106
48	MP0005187_abnormal_penis_morphology	1.13820611
49	MP0002277_abnormal_respiratory_mucosa	1.13006243
50	MP0001661_extended_life_span	1.10642403
51	MP0005646_abnormal_pituitary_gland	1.07852502
52	MP0002095_abnormal_skin_pigmentation	1.06546981
53	MP0003724_increased_susceptibility_to	1.06272335
54	MP0002272_abnormal_nervous_system	1.06142632
55	MP0003136_yellow_coat_color	1.04606084
56	MP0003786_premature_aging	1.03058132
57	MP0005084_abnormal_gallbladder_morpholo	1.02557295
58	MP0004142_abnormal_muscle_tone	1.02422159
59	MP0000383_abnormal_hair_follicle	1.02322394
60	MP0001963_abnormal_hearing_physiology	1.02288670
61	MP0002736_abnormal_nociception_after	1.01572792
62	MP0001790_abnormal_immune_system	1.00819923
63	MP0005387_immune_system_phenotype	1.00819923
64	MP0002723_abnormal_immune_serum	0.99330905
65	MP0008569_lethality_at_weaning	0.96701313
66	MP0008057_abnormal_DNA_replication	0.94810553
67	MP0001765_abnormal_ion_homeostasis	0.92508915
68	MP0003119_abnormal_digestive_system	0.92030454
69	MP0003195_calcinosis	0.91226326
70	MP0009765_abnormal_xenobiotic_induced	0.90510420
71	MP0003252_abnormal_bile_duct	0.88715000
72	MP0002160_abnormal_reproductive_system	0.87258353
73	MP0005377_hearing/vestibular/ear_phenot	0.87231981
74	MP0003878_abnormal_ear_physiology	0.87231981
75	MP0000049_abnormal_middle_ear	0.85756897
76	MP0004147_increased_porphyrin_level	0.83722842
77	MP0002822_catalepsy	0.82437929
78	MP0008775_abnormal_heart_ventricle	0.81314291
79	MP0003567_abnormal_fetal_cardiomyocyte	0.80820144
80	MP0005386_behavior/neurological_phenoty	0.80655004
81	MP0004924_abnormal_behavior	0.80655004
82	MP0002452_abnormal_antigen_presenting	0.79254342
83	MP0000647_abnormal_sebaceous_gland	0.79023950
84	MP0001819_abnormal_immune_cell	0.78547706
85	MP0002234_abnormal_pharynx_morphology	0.77926303
86	MP0002420_abnormal_adaptive_immunity	0.77627714
87	MP0002876_abnormal_thyroid_physiology	0.76420627
88	MP0009333_abnormal_splenocyte_physiolog	0.74706861
89	MP0001346_abnormal_lacrimal_gland	0.74160301
90	MP0004215_abnormal_myocardial_fiber	0.73557969
91	MP0009745_abnormal_behavioral_response	0.72257474
92	MP0005410_abnormal_fertilization	0.72238735
93	MP0004145_abnormal_muscle_electrophysio	0.71650573
94	MP0002722_abnormal_immune_system	0.70950705
95	MP0000703_abnormal_thymus_morphology	0.70630561
96	MP0004134_abnormal_chest_morphology	0.70134900
97	MP0005636_abnormal_mineral_homeostasis	0.69498226
98	MP0008789_abnormal_olfactory_epithelium	0.69418021
99	MP0002735_abnormal_chemical_nociception	0.68604286
100	MP0001929_abnormal_gametogenesis	0.68468170

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of B cell number (HP:0010975)	3.91260622
2	Abolished electroretinogram (ERG) (HP:0000550)	3.90074711
3	B lymphocytopenia (HP:0010976)	3.80515669
4	3-Methylglutaconic aciduria (HP:0003535)	3.74042850
5	Colon cancer (HP:0003003)	3.70994180
6	Mitochondrial inheritance (HP:0001427)	3.31777559
7	Increased CSF lactate (HP:0002490)	3.19037555
8	Increased hepatocellular lipid droplets (HP:0006565)	3.15282264
9	Acute necrotizing encephalopathy (HP:0006965)	3.13053999
10	Large for gestational age (HP:0001520)	2.99496112
11	Lipid accumulation in hepatocytes (HP:0006561)	2.96774769
12	Increased serum lactate (HP:0002151)	2.90227437
13	IgG deficiency (HP:0004315)	2.88630563
14	Pendular nystagmus (HP:0012043)	2.85437453
15	Abnormal gallbladder physiology (HP:0012438)	2.82891741
16	Cholecystitis (HP:0001082)	2.82891741
17	Hepatocellular necrosis (HP:0001404)	2.79048739
18	Attenuation of retinal blood vessels (HP:0007843)	2.73628729
19	Hypoalbuminemia (HP:0003073)	2.62022428
20	Abnormal albumin level (HP:0012116)	2.62022428
21	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.57906951
22	Cerebellar dysplasia (HP:0007033)	2.56264256
23	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.56050148
24	Fibular aplasia (HP:0002990)	2.51865394
25	Type II lissencephaly (HP:0007260)	2.51343850
26	Abnormal mitochondria in muscle tissue (HP:0008316)	2.49039386
27	Hypoplasia of the uterus (HP:0000013)	2.42498662
28	Short tibia (HP:0005736)	2.41721961
29	Cerebral edema (HP:0002181)	2.39814336
30	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.39023147
31	Acute encephalopathy (HP:0006846)	2.37971975
32	Progressive macrocephaly (HP:0004481)	2.37125326
33	Abnormality of the pons (HP:0007361)	2.36892326
34	Pancreatic cysts (HP:0001737)	2.36623482
35	Congenital, generalized hypertrichosis (HP:0004540)	2.35294194
36	Keratoconjunctivitis (HP:0001096)	2.35195399
37	Stomach cancer (HP:0012126)	2.33625220
38	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.31699710
39	Chronic mucocutaneous candidiasis (HP:0002728)	2.30803456
40	Recurrent cutaneous fungal infections (HP:0011370)	2.30803456
41	Increased density of long bones (HP:0006392)	2.30158980
42	Type 2 muscle fiber atrophy (HP:0003554)	2.27868013
43	Asplenia (HP:0001746)	2.27162290
44	Type I transferrin isoform profile (HP:0003642)	2.25869032
45	Abnormal number of erythroid precursors (HP:0012131)	2.24139150
46	Persistence of primary teeth (HP:0006335)	2.23117812
47	Congenital stationary night blindness (HP:0007642)	2.22879138
48	Lactic acidosis (HP:0003128)	2.22036698
49	Decreased central vision (HP:0007663)	2.21413859
50	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.21341432
51	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.20570788
52	Reduced antithrombin III activity (HP:0001976)	2.20481161
53	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.19041943
54	Hepatic necrosis (HP:0002605)	2.17957164
55	Severe combined immunodeficiency (HP:0004430)	2.13487944
56	Nephronophthisis (HP:0000090)	2.07144982
57	Muscle fiber atrophy (HP:0100295)	2.06257281
58	Aplasia/hypoplasia of the uterus (HP:0008684)	2.06182968
59	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.02639364
60	Conjunctival hamartoma (HP:0100780)	2.01799075
61	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.00643920
62	Parakeratosis (HP:0001036)	2.00605890
63	Optic disc pallor (HP:0000543)	2.00564997
64	Abnormal protein glycosylation (HP:0012346)	1.98989310
65	Abnormal glycosylation (HP:0012345)	1.98989310
66	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.98989310
67	Abnormal protein N-linked glycosylation (HP:0012347)	1.98989310
68	Renal Fanconi syndrome (HP:0001994)	1.95300481
69	Abnormality of DNA repair (HP:0003254)	1.94168099
70	Hypoplastic pelvis (HP:0008839)	1.93938871
71	Hypokalemic alkalosis (HP:0001949)	1.90074231
72	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.89480161
73	Hyperinsulinemic hypoglycemia (HP:0000825)	1.88304204
74	Abnormality of the middle phalanges of the toes (HP:0010183)	1.88100513
75	Oral leukoplakia (HP:0002745)	1.86031632
76	Abnormality of the renal collecting system (HP:0004742)	1.83786724
77	Exertional dyspnea (HP:0002875)	1.83643544
78	Pancreatic fibrosis (HP:0100732)	1.83449255
79	Duplicated collecting system (HP:0000081)	1.82690710
80	Septo-optic dysplasia (HP:0100842)	1.80412879
81	Premature loss of primary teeth (HP:0006323)	1.78495362
82	True hermaphroditism (HP:0010459)	1.78285105
83	Hypomagnesemia (HP:0002917)	1.78025174
84	Adenoma sebaceum (HP:0009720)	1.77767260
85	Angiofibromas (HP:0010615)	1.77767260
86	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.76433082
87	Rhinitis (HP:0012384)	1.76143013
88	Prostate neoplasm (HP:0100787)	1.75782469
89	Abnormality of the renal cortex (HP:0011035)	1.74653150
90	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.73378093
91	Abnormality of the renal medulla (HP:0100957)	1.72244756
92	Bony spicule pigmentary retinopathy (HP:0007737)	1.71924558
93	Lissencephaly (HP:0001339)	1.71462034
94	CNS hypomyelination (HP:0003429)	1.71206057
95	Adactyly (HP:0009776)	1.70855001
96	Abnormality of cells of the erythroid lineage (HP:0012130)	1.69701964
97	Hypoplasia of the ulna (HP:0003022)	1.69369353
98	Methylmalonic acidemia (HP:0002912)	1.68896236
99	Respiratory failure (HP:0002878)	1.67101195
100	Pancytopenia (HP:0001876)	1.66308702

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	5.10800942
2	TAOK3	4.60821574
3	VRK2	3.81873495
4	GRK6	3.26558781
5	TESK2	2.78174168
6	TLK1	2.74492080
7	TXK	2.69787376
8	NUAK1	2.69627436
9	PBK	2.33661997
10	TNIK	2.14679388
11	ZAK	2.03933459
12	TSSK6	2.02911665
13	WNK4	1.77614531
14	TAF1	1.69103454
15	VRK1	1.56122727
16	GRK1	1.51948821
17	ADRBK2	1.48130849
18	TIE1	1.42104944
19	BMPR1B	1.41243947
20	MAP2K2	1.37338427
21	EIF2AK1	1.37079425
22	CSNK1G3	1.35304097
23	STK39	1.31604455
24	MAP4K2	1.26702077
25	EIF2AK3	1.25913592
26	CSNK1A1L	1.23419511
27	KIT	1.21368912
28	CSF1R	1.16902084
29	MKNK2	1.07705825
30	NME2	1.07596845
31	MKNK1	1.07029146
32	MST4	1.06887007
33	OXSR1	1.06389306
34	CCNB1	1.06101893
35	MAP4K1	1.03243900
36	CSNK1G1	1.02941452
37	CSNK1G2	1.01441372
38	STK38L	1.00548183
39	NEK1	0.99615235
40	NEK9	0.96630593
41	PLK2	0.90436424
42	FES	0.88421487
43	EIF2AK2	0.86687035
44	CLK1	0.85475475
45	GRK7	0.84704592
46	PLK3	0.84613300
47	DAPK1	0.78243451
48	IKBKB	0.75630044
49	PIK3CG	0.74380978
50	ACVR1B	0.74208395
51	SYK	0.72240116
52	GRK5	0.71490655
53	DYRK2	0.68713699
54	INSRR	0.67709847
55	SRPK1	0.65925290
56	TEC	0.64400512
57	STK16	0.64081270
58	MAPKAPK5	0.63135688
59	TRIM28	0.62663949
60	PHKG1	0.62350847
61	PHKG2	0.62350847
62	ATR	0.61669247
63	WNK3	0.61643197
64	BUB1	0.60603509
65	ITK	0.60450928
66	PRKCQ	0.57365327
67	AURKB	0.55507848
68	FLT3	0.54903486
69	CDK8	0.53415217
70	MAP3K4	0.53113101
71	LCK	0.52739466
72	ADRBK1	0.51978616
73	MAP2K6	0.51850287
74	LYN	0.50635856
75	PTK2B	0.49053868
76	ABL2	0.48320487
77	NME1	0.47907925
78	PASK	0.46704556
79	PRKCG	0.46400458
80	CSNK2A2	0.44638720
81	BMPR2	0.44551592
82	KDR	0.43876426
83	STK4	0.42189473
84	PLK1	0.42054301
85	SMG1	0.41637191
86	IGF1R	0.41078525
87	MAP3K14	0.39379549
88	CSNK2A1	0.39198512
89	TGFBR1	0.38216416
90	PKN1	0.37376713
91	STK3	0.35708114
92	NTRK2	0.34853760
93	FRK	0.34829333
94	CHEK1	0.33368232
95	ALK	0.32779279
96	LATS1	0.32357630
97	TBK1	0.32015230
98	AURKA	0.31741840
99	PAK3	0.31479162
100	DAPK3	0.30789985

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.78291829
2	RNA polymerase_Homo sapiens_hsa03020	3.51322087
3	Proteasome_Homo sapiens_hsa03050	3.04020806
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.87259363
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.58941850
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.47904065
7	Ribosome_Homo sapiens_hsa03010	2.13949823
8	RNA degradation_Homo sapiens_hsa03018	2.10988933
9	Protein export_Homo sapiens_hsa03060	1.97253019
10	DNA replication_Homo sapiens_hsa03030	1.94580258
11	Asthma_Homo sapiens_hsa05310	1.87510255
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.86155067
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.80774403
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.80335950
15	Pyrimidine metabolism_Homo sapiens_hsa00240	1.79476391
16	One carbon pool by folate_Homo sapiens_hsa00670	1.78119233
17	Phototransduction_Homo sapiens_hsa04744	1.76361571
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.76295227
19	Homologous recombination_Homo sapiens_hsa03440	1.74318502
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.68644699
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.67936144
22	Mismatch repair_Homo sapiens_hsa03430	1.64004973
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.59014396
24	RNA transport_Homo sapiens_hsa03013	1.52900608
25	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.52398562
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.51739995
27	Allograft rejection_Homo sapiens_hsa05330	1.50899512
28	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.48727586
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.46822341
30	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.45685576
31	Spliceosome_Homo sapiens_hsa03040	1.44000854
32	Purine metabolism_Homo sapiens_hsa00230	1.42532648
33	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.41339068
34	Parkinsons disease_Homo sapiens_hsa05012	1.40998842
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.36777090
36	Caffeine metabolism_Homo sapiens_hsa00232	1.36445575
37	Basal transcription factors_Homo sapiens_hsa03022	1.30757966
38	Linoleic acid metabolism_Homo sapiens_hsa00591	1.28571206
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.20644391
40	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.17922613
41	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.11236132
42	Fatty acid elongation_Homo sapiens_hsa00062	1.04501187
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.03998101
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.01295731
45	Base excision repair_Homo sapiens_hsa03410	0.99050369
46	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.98942764
47	Non-homologous end-joining_Homo sapiens_hsa03450	0.98057040
48	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.95786331
49	Nitrogen metabolism_Homo sapiens_hsa00910	0.92643815
50	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.91043831
51	Rheumatoid arthritis_Homo sapiens_hsa05323	0.90600171
52	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.87056008
53	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.82514346
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.82174359
55	Huntingtons disease_Homo sapiens_hsa05016	0.81953393
56	Propanoate metabolism_Homo sapiens_hsa00640	0.80792161
57	Graft-versus-host disease_Homo sapiens_hsa05332	0.79896060
58	Peroxisome_Homo sapiens_hsa04146	0.79071271
59	Type I diabetes mellitus_Homo sapiens_hsa04940	0.78653233
60	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.77899517
61	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.74399541
62	Nicotine addiction_Homo sapiens_hsa05033	0.66469867
63	Alzheimers disease_Homo sapiens_hsa05010	0.66052422
64	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.62970946
65	Antigen processing and presentation_Homo sapiens_hsa04612	0.61062065
66	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.58978214
67	Phenylalanine metabolism_Homo sapiens_hsa00360	0.58156257
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.56184957
69	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.55550893
70	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.55081157
71	Metabolic pathways_Homo sapiens_hsa01100	0.54968807
72	Olfactory transduction_Homo sapiens_hsa04740	0.54452620
73	Taste transduction_Homo sapiens_hsa04742	0.52689269
74	Glutathione metabolism_Homo sapiens_hsa00480	0.51958173
75	Selenocompound metabolism_Homo sapiens_hsa00450	0.51105590
76	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47698706
77	Cardiac muscle contraction_Homo sapiens_hsa04260	0.47275915
78	mRNA surveillance pathway_Homo sapiens_hsa03015	0.47075914
79	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.47025992
80	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.46808045
81	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.46539039
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.46039698
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.45185492
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.43469813
85	Salivary secretion_Homo sapiens_hsa04970	0.42010570
86	Butanoate metabolism_Homo sapiens_hsa00650	0.41206047
87	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.40989601
88	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.38702107
89	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.38163371
90	ABC transporters_Homo sapiens_hsa02010	0.37817536
91	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.35716827
92	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.35053998
93	Collecting duct acid secretion_Homo sapiens_hsa04966	0.34653303
94	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.34592250
95	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.33881933
96	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.33669562
97	Tyrosine metabolism_Homo sapiens_hsa00350	0.32073402
98	Sulfur metabolism_Homo sapiens_hsa00920	0.32025110
99	Arginine and proline metabolism_Homo sapiens_hsa00330	0.31734346
100	Morphine addiction_Homo sapiens_hsa05032	0.31345227

HNRNPA1P13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »