HNRNPA1P17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.77806075
2regulation of memory T cell differentiation (GO:0043380)5.30455746
3DNA deamination (GO:0045006)5.08931107
4regulation of interleukin-12 biosynthetic process (GO:0045075)4.89334271
5cellular response to interleukin-15 (GO:0071350)4.71195353
6positive regulation of T cell mediated cytotoxicity (GO:0001916)4.66882726
7positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.65645169
8cytidine deamination (GO:0009972)4.57750049
9cytidine metabolic process (GO:0046087)4.57750049
10cytidine catabolic process (GO:0006216)4.57750049
11regulation of isotype switching to IgG isotypes (GO:0048302)4.50331668
12regulation of chronic inflammatory response (GO:0002676)4.45630036
13regulation of vitamin D biosynthetic process (GO:0060556)4.37508331
14Peyers patch development (GO:0048541)4.34546414
15mucosal-associated lymphoid tissue development (GO:0048537)4.34546414
16regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.16796481
17regulation of T cell mediated cytotoxicity (GO:0001914)4.14415827
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.12086809
19regulation of regulatory T cell differentiation (GO:0045589)4.00469287
20positive regulation of cell killing (GO:0031343)4.00242338
21positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.96951942
22positive regulation of cell fate commitment (GO:0010455)3.94224819
23purine deoxyribonucleotide catabolic process (GO:0009155)3.93476662
24response to interleukin-15 (GO:0070672)3.92406009
25negative regulation of calcium ion transport into cytosol (GO:0010523)3.88424217
26negative regulation of cell killing (GO:0031342)3.76624775
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.76624775
28natural killer cell differentiation (GO:0001779)3.72162893
29positive regulation of osteoclast differentiation (GO:0045672)3.71526774
30base-excision repair, AP site formation (GO:0006285)3.68069287
31pyrimidine ribonucleoside catabolic process (GO:0046133)3.64359236
32sequestering of actin monomers (GO:0042989)3.63450225
33regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.63090877
34regulation of leukocyte mediated cytotoxicity (GO:0001910)3.60181376
35positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.59957269
36regulation of cell killing (GO:0031341)3.59439419
37positive regulation of interleukin-12 production (GO:0032735)3.54060337
38regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.53807384
39regulation of vitamin metabolic process (GO:0030656)3.53090958
40leukocyte aggregation (GO:0070486)3.31685294
41positive regulation of defense response to virus by host (GO:0002230)3.23901902
42regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.23616734
43positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.23616734
44positive regulation of humoral immune response (GO:0002922)3.17846487
45regulation of activation of Janus kinase activity (GO:0010533)3.13612647
46mast cell activation (GO:0045576)3.13416520
47tolerance induction (GO:0002507)3.09458732
48peptidyl-arginine omega-N-methylation (GO:0035247)3.07444237
49positive regulation of immunoglobulin mediated immune response (GO:0002891)3.05163721
50positive regulation of B cell mediated immunity (GO:0002714)3.05163721
51rRNA catabolic process (GO:0016075)3.05125275
52positive regulation of natural killer cell mediated immunity (GO:0002717)3.04738620
53positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.03663072
54negative T cell selection (GO:0043383)3.03453780
55positive regulation of T cell mediated immunity (GO:0002711)3.03374468
56negative regulation of monooxygenase activity (GO:0032769)3.03364044
57axoneme assembly (GO:0035082)3.02666890
58positive regulation of lymphocyte mediated immunity (GO:0002708)2.97935892
59positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.96057005
60chaperone-mediated protein transport (GO:0072321)2.95527074
61preassembly of GPI anchor in ER membrane (GO:0016254)2.95192703
62regulation of interleukin-1 beta secretion (GO:0050706)2.94605285
63negative regulation of interleukin-17 production (GO:0032700)2.94187616
64natural killer cell activation (GO:0030101)2.94007744
65platelet dense granule organization (GO:0060155)2.90923142
66negative regulation of mast cell activation (GO:0033004)2.90235924
67positive regulation of isotype switching (GO:0045830)2.88491379
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.86703756
69GDP-mannose metabolic process (GO:0019673)2.85995954
70regulation of interleukin-17 production (GO:0032660)2.84760079
71negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.83810472
72ubiquinone biosynthetic process (GO:0006744)2.83318728
73water-soluble vitamin biosynthetic process (GO:0042364)2.78854421
74regulation of growth of symbiont in host (GO:0044126)2.77954784
75negative regulation of growth of symbiont in host (GO:0044130)2.77954784
76negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.77954784
77modulation of growth of symbiont involved in interaction with host (GO:0044144)2.77954784
78negative regulation of metanephros development (GO:0072217)2.77769171
79negative thymic T cell selection (GO:0045060)2.77596808
80organelle membrane fusion (GO:0090174)2.77217120
81lymph node development (GO:0048535)2.76578552
82positive regulation of interleukin-17 production (GO:0032740)2.76215727
83negative regulation of interleukin-1 beta production (GO:0032691)2.76141969
84metallo-sulfur cluster assembly (GO:0031163)2.75492511
85iron-sulfur cluster assembly (GO:0016226)2.75492511
86positive regulation of tolerance induction (GO:0002645)2.75042080
87regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.74882000
88regulation of natural killer cell mediated immunity (GO:0002715)2.74882000
89positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.74064718
90positive regulation of DNA recombination (GO:0045911)2.71203453
91ribosomal small subunit assembly (GO:0000028)2.70779882
92regulation of interleukin-12 production (GO:0032655)2.69851596
93positive regulation of interleukin-1 beta secretion (GO:0050718)2.68488430
94negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.68096273
95positive regulation of T-helper 1 type immune response (GO:0002827)2.63853448
96GPI anchor metabolic process (GO:0006505)2.63395251
97chaperone mediated protein folding requiring cofactor (GO:0051085)2.62146039
98negative regulation of innate immune response (GO:0045824)2.60741093
99mast cell activation involved in immune response (GO:0002279)2.60361672
100mast cell degranulation (GO:0043303)2.60361672

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.89940631
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.52166145
3VDR_22108803_ChIP-Seq_LS180_Human3.15045030
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.92545586
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.80355351
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.80104524
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.79223119
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.73007258
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.71063943
10RUNX_20019798_ChIP-Seq_JUKART_Human2.61043074
11ZNF274_21170338_ChIP-Seq_K562_Hela2.58563645
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.51872977
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.47868141
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39100288
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.34669626
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27311375
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.22694559
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.18157752
19VDR_23849224_ChIP-Seq_CD4+_Human2.16980665
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.14359227
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13684793
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.05858626
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05439499
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.00295742
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96296876
26MYB_26560356_Chip-Seq_TH2_Human1.93312713
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.84593044
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82552924
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.81597104
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.71461607
31GATA3_26560356_Chip-Seq_TH2_Human1.68327492
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64859028
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63780148
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62751617
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.61494949
36FOXP3_21729870_ChIP-Seq_TREG_Human1.57697146
37IRF1_19129219_ChIP-ChIP_H3396_Human1.57686347
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57601153
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56660777
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55692049
41IGF1R_20145208_ChIP-Seq_DFB_Human1.55108955
42TP53_22573176_ChIP-Seq_HFKS_Human1.48670152
43ER_23166858_ChIP-Seq_MCF-7_Human1.47728095
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47690936
45GATA3_27048872_Chip-Seq_THYMUS_Human1.44253315
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.44184997
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37748486
48AR_20517297_ChIP-Seq_VCAP_Human1.35629713
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35511334
50MYC_18940864_ChIP-ChIP_HL60_Human1.35060197
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34579689
52NANOG_20526341_ChIP-Seq_ESCs_Human1.29624815
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27807002
54CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.24829323
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24428970
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24132657
57FOXA1_25329375_ChIP-Seq_VCAP_Human1.24132657
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.23146400
59EWS_26573619_Chip-Seq_HEK293_Human1.22947886
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22056054
61TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21021833
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19795988
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.17266868
64RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16724516
65MYB_26560356_Chip-Seq_TH1_Human1.15813031
66PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15234272
67UTX_26944678_Chip-Seq_JUKART_Human1.14631704
68ELK1_19687146_ChIP-ChIP_HELA_Human1.13118115
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08978128
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.08164552
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06732304
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05763530
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05540816
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05532545
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.04819985
76GATA1_22025678_ChIP-Seq_K562_Human1.04404606
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02327532
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00707181
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97057627
80CBP_20019798_ChIP-Seq_JUKART_Human0.97057627
81FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97023476
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95860236
83HOXB7_26014856_ChIP-Seq_BT474_Human0.95401968
84MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95153437
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94369331
86GATA3_26560356_Chip-Seq_TH1_Human0.94346477
87GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92898026
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92586985
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92374520
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92339397
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92006877
92RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91944066
93NANOG_19829295_ChIP-Seq_ESCs_Human0.91940459
94SOX2_19829295_ChIP-Seq_ESCs_Human0.91940459
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.91891189
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90843138
97MYC_19829295_ChIP-Seq_ESCs_Human0.90012961
98RBPJ_21746931_ChIP-Seq_IB4_Human0.89604380
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88516795
100NCOR_22424771_ChIP-Seq_293T_Human0.87499374

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.68370872
2MP0005377_hearing/vestibular/ear_phenot3.78739869
3MP0003878_abnormal_ear_physiology3.78739869
4MP0003436_decreased_susceptibility_to3.71324409
5MP0005257_abnormal_intraocular_pressure3.68117915
6MP0001835_abnormal_antigen_presentation3.17216508
7MP0009785_altered_susceptibility_to3.01839224
8MP0008872_abnormal_physiological_respon2.95436372
9MP0001873_stomach_inflammation2.89769508
10MP0005000_abnormal_immune_tolerance2.68590552
11MP0000372_irregular_coat_pigmentation2.46836952
12MP0009333_abnormal_splenocyte_physiolog2.37722050
13MP0008057_abnormal_DNA_replication2.29124270
14MP0000685_abnormal_immune_system2.01734977
15MP0002405_respiratory_system_inflammati2.00149771
16MP0006072_abnormal_retinal_apoptosis1.99439856
17MP0001800_abnormal_humoral_immune1.98047966
18MP0002148_abnormal_hypersensitivity_rea1.95921244
19MP0001485_abnormal_pinna_reflex1.92742194
20MP0003763_abnormal_thymus_physiology1.92216764
21MP0001790_abnormal_immune_system1.86797057
22MP0005387_immune_system_phenotype1.86797057
23MP0008875_abnormal_xenobiotic_pharmacok1.81761380
24MP0002723_abnormal_immune_serum1.77134024
25MP0001501_abnormal_sleep_pattern1.72523281
26MP0002420_abnormal_adaptive_immunity1.72348181
27MP0001819_abnormal_immune_cell1.71764547
28MP0010155_abnormal_intestine_physiology1.60244316
29MP0003646_muscle_fatigue1.56942406
30MP0001533_abnormal_skeleton_physiology1.56914567
31MP0005025_abnormal_response_to1.52693060
32MP0002933_joint_inflammation1.52047407
33MP0004742_abnormal_vestibular_system1.51408083
34MP0002452_abnormal_antigen_presenting1.47593686
35MP0002006_tumorigenesis1.44158184
36MP0001346_abnormal_lacrimal_gland1.42974424
37MP0004885_abnormal_endolymph1.41795909
38MP0008877_abnormal_DNA_methylation1.40210120
39MP0002102_abnormal_ear_morphology1.40154162
40MP0003195_calcinosis1.39088131
41MP0000703_abnormal_thymus_morphology1.37500348
42MP0005310_abnormal_salivary_gland1.35467126
43MP0005645_abnormal_hypothalamus_physiol1.33696014
44MP0001845_abnormal_inflammatory_respons1.30062856
45MP0002419_abnormal_innate_immunity1.29730258
46MP0002722_abnormal_immune_system1.27958949
47MP0006036_abnormal_mitochondrial_physio1.26405707
48MP0000716_abnormal_immune_system1.25326985
49MP0009764_decreased_sensitivity_to1.23131347
50MP0005646_abnormal_pituitary_gland1.20206274
51MP0004782_abnormal_surfactant_physiolog1.15938025
52MP0001905_abnormal_dopamine_level1.15519784
53MP0006035_abnormal_mitochondrial_morpho1.12005800
54MP0003866_abnormal_defecation1.11468168
55MP0008058_abnormal_DNA_repair1.10826914
56MP0000689_abnormal_spleen_morphology1.10637415
57MP0005551_abnormal_eye_electrophysiolog1.07959994
58MP0002163_abnormal_gland_morphology1.07547999
59MP0002398_abnormal_bone_marrow1.05846706
60MP0001881_abnormal_mammary_gland1.04523250
61MP0001919_abnormal_reproductive_system1.04437985
62MP0001984_abnormal_olfaction1.03857677
63MP0008469_abnormal_protein_level1.02093608
64MP0003806_abnormal_nucleotide_metabolis0.98263547
65MP0005085_abnormal_gallbladder_physiolo0.97970674
66MP0001853_heart_inflammation0.96501537
67MP0003724_increased_susceptibility_to0.94711162
68MP0005389_reproductive_system_phenotype0.93958193
69MP0002429_abnormal_blood_cell0.92940708
70MP0001663_abnormal_digestive_system0.91716920
71MP0005365_abnormal_bile_salt0.88828416
72MP0005253_abnormal_eye_physiology0.88774347
73MP0003786_premature_aging0.86772807
74MP0005636_abnormal_mineral_homeostasis0.84571386
75MP0000569_abnormal_digit_pigmentation0.83950206
76MP0000383_abnormal_hair_follicle0.83559194
77MP0005075_abnormal_melanosome_morpholog0.81075649
78MP0005360_urolithiasis0.78883437
79MP0005390_skeleton_phenotype0.78651412
80MP0006292_abnormal_olfactory_placode0.78199632
81MP0002693_abnormal_pancreas_physiology0.75732578
82MP0004142_abnormal_muscle_tone0.75617993
83MP0002876_abnormal_thyroid_physiology0.74961202
84MP0002160_abnormal_reproductive_system0.74145173
85MP0003137_abnormal_impulse_conducting0.73691551
86MP0001661_extended_life_span0.73448154
87MP0005379_endocrine/exocrine_gland_phen0.73116197
88MP0002138_abnormal_hepatobiliary_system0.71819131
89MP0002234_abnormal_pharynx_morphology0.71055078
90MP0005670_abnormal_white_adipose0.70129741
91MP0002166_altered_tumor_susceptibility0.69731263
92MP0002019_abnormal_tumor_incidence0.69654761
93MP0000465_gastrointestinal_hemorrhage0.69362584
94MP0003879_abnormal_hair_cell0.68871514
95MP0001765_abnormal_ion_homeostasis0.68437929
96MP0009697_abnormal_copulation0.68349874
97MP0006054_spinal_hemorrhage0.67229284
98MP0004957_abnormal_blastocyst_morpholog0.66867863
99MP0002751_abnormal_autonomic_nervous0.66018943
100MP0003448_altered_tumor_morphology0.65973022

Predicted human phenotypes

RankGene SetZ-score
1Stomach cancer (HP:0012126)6.74777854
2Abnormality of B cell number (HP:0010975)6.74006823
3Abnormality of T cell number (HP:0011839)4.27913962
4Increased IgM level (HP:0003496)4.27041431
5IgG deficiency (HP:0004315)4.21431429
6B lymphocytopenia (HP:0010976)4.19154269
7Congenital stationary night blindness (HP:0007642)4.11107155
8Reduced antithrombin III activity (HP:0001976)3.78936865
9Eosinophilia (HP:0001880)3.68723960
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.63519600
11Abnormality of eosinophils (HP:0001879)3.60483404
12Autoimmune thrombocytopenia (HP:0001973)3.55385955
13Methylmalonic acidemia (HP:0002912)3.40321408
14Optic neuritis (HP:0100653)3.30873341
15Retrobulbar optic neuritis (HP:0100654)3.30873341
16T lymphocytopenia (HP:0005403)3.28700739
17Methylmalonic aciduria (HP:0012120)3.14899945
18Increased intramyocellular lipid droplets (HP:0012240)3.09098665
19Autoimmune hemolytic anemia (HP:0001890)3.03600462
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.01656404
21Mitochondrial inheritance (HP:0001427)3.01502445
22Abnormality of T cells (HP:0002843)2.94610894
23Congenital, generalized hypertrichosis (HP:0004540)2.91667864
24Granulocytopenia (HP:0001913)2.82391474
25Type I transferrin isoform profile (HP:0003642)2.76076622
26Acute necrotizing encephalopathy (HP:0006965)2.74713889
27Absent/shortened dynein arms (HP:0200106)2.73037942
28Dynein arm defect of respiratory motile cilia (HP:0012255)2.73037942
29Orchitis (HP:0100796)2.70305988
30Increased hepatocellular lipid droplets (HP:0006565)2.69869315
31Leukocytosis (HP:0001974)2.66609590
32Increased CSF lactate (HP:0002490)2.66188797
33Abnormal rod and cone electroretinograms (HP:0008323)2.60859227
34Stomatitis (HP:0010280)2.60307352
35Attenuation of retinal blood vessels (HP:0007843)2.58460289
36Increased muscle lipid content (HP:0009058)2.57843292
37Renal cortical cysts (HP:0000803)2.57610656
38Abnormal mitochondria in muscle tissue (HP:0008316)2.54487825
39Abnormality of the renal cortex (HP:0011035)2.54411002
40Myositis (HP:0100614)2.53836378
41Abnormality of T cell physiology (HP:0011840)2.53835373
42Keratoconjunctivitis (HP:0001096)2.48921290
43Colon cancer (HP:0003003)2.47745948
44Abnormality of the pons (HP:0007361)2.47731772
45Hepatocellular necrosis (HP:0001404)2.45107456
46Abnormal ciliary motility (HP:0012262)2.40222877
47Hyperglycinemia (HP:0002154)2.39894755
48Carpal bone hypoplasia (HP:0001498)2.34974544
49Lipid accumulation in hepatocytes (HP:0006561)2.34907610
50Decreased electroretinogram (ERG) amplitude (HP:0000654)2.34373456
51Hypoplasia of the pons (HP:0012110)2.25367666
52Metabolic alkalosis (HP:0200114)2.24726772
53Abnormal respiratory motile cilium morphology (HP:0005938)2.23135520
54Abnormal respiratory epithelium morphology (HP:0012253)2.23135520
55Progressive macrocephaly (HP:0004481)2.17634724
56Severe combined immunodeficiency (HP:0004430)2.17297580
57Hypokalemic alkalosis (HP:0001949)2.17226355
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16143126
593-Methylglutaconic aciduria (HP:0003535)2.15427915
60Exertional dyspnea (HP:0002875)2.09520117
61Keratoconjunctivitis sicca (HP:0001097)2.08731113
62Abnormality of the vitamin B12 metabolism (HP:0004341)2.08429697
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.07721346
64Abnormal protein N-linked glycosylation (HP:0012347)2.07721346
65Abnormal protein glycosylation (HP:0012346)2.07721346
66Abnormal glycosylation (HP:0012345)2.07721346
67Arthropathy (HP:0003040)2.07020493
68Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.04674081
69Hyperphosphaturia (HP:0003109)2.04087892
70Hepatic necrosis (HP:0002605)2.03446492
71Abolished electroretinogram (ERG) (HP:0000550)2.01510951
72Acute encephalopathy (HP:0006846)2.00643421
73Neutropenia (HP:0001875)1.98136339
74Hypoproteinemia (HP:0003075)1.97292320
75Abnormality of vitamin B metabolism (HP:0004340)1.95680785
76Pancreatic cysts (HP:0001737)1.94130662
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92813085
78Encephalitis (HP:0002383)1.91931796
79Constricted visual fields (HP:0001133)1.91915563
80Anhidrosis (HP:0000970)1.91618654
81Ketosis (HP:0001946)1.90141396
82Lactic acidosis (HP:0003128)1.90011490
83Chronic diarrhea (HP:0002028)1.89569199
84Thyroiditis (HP:0100646)1.87998196
85Elevated erythrocyte sedimentation rate (HP:0003565)1.87960066
86Abnormal respiratory motile cilium physiology (HP:0012261)1.87903031
87Increased serum lactate (HP:0002151)1.85839121
88Pendular nystagmus (HP:0012043)1.84050813
89Cerebral edema (HP:0002181)1.83371558
90Pulmonary infiltrates (HP:0002113)1.83287906
91Renal salt wasting (HP:0000127)1.81558352
92Abnormality of chloride homeostasis (HP:0011422)1.80579106
93IgA deficiency (HP:0002720)1.80513289
94Recurrent bronchitis (HP:0002837)1.80262165
95Hypomagnesemia (HP:0002917)1.78797724
96Respiratory failure (HP:0002878)1.77745123
97Keratitis (HP:0000491)1.77333898
98Hypoalbuminemia (HP:0003073)1.75210915
99Abnormal albumin level (HP:0012116)1.75210915
100Medial flaring of the eyebrow (HP:0010747)1.75131315

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK14.52338914
2GRK64.47798833
3BCKDK4.12815273
4MAP4K24.03810256
5TXK3.97856715
6TSSK63.59238761
7PASK2.72446098
8ZAK2.64934161
9CAMKK22.22955293
10KDR2.10978344
11ADRBK22.07388811
12VRK22.00993486
13TAOK31.89938659
14EIF2AK11.83263224
15ERBB31.81594480
16NME11.78533360
17TESK21.75335445
18GRK11.72073957
19TLK11.69799837
20MST41.62532861
21CAMKK11.61864988
22MAP3K91.52010368
23NUAK11.48939306
24EIF2AK31.43587873
25IKBKE1.29753510
26NME21.25946438
27MATK1.22699823
28MAP2K21.18862199
29IKBKB1.11463449
30ITK1.09407681
31JAK11.08833802
32ARAF1.08648260
33IRAK41.07620601
34SRPK11.04195468
35VRK11.03383009
36ALK0.98033110
37MAP3K140.95825028
38MAP3K120.95340297
39BMPR20.93741010
40JAK30.92882064
41FRK0.91901836
42LCK0.89078550
43BTK0.88818447
44NEK60.86052731
45PRKCQ0.83804963
46PIM10.82002620
47CSNK1G30.80266590
48CSNK1G10.80176883
49MAP2K60.80064667
50NTRK10.79758652
51TBK10.72480765
52MAP4K10.72261038
53INSRR0.71801048
54CSNK1A1L0.71631268
55RAF10.67871126
56MAP3K110.67174365
57PLK30.66476000
58TRPM70.64906899
59SYK0.64807333
60STK240.62385972
61MAP3K50.61762172
62FLT30.61478956
63TEC0.58435497
64MYLK0.54177229
65IGF1R0.53864510
66CDK190.52309515
67TAOK10.52101136
68TAOK20.52080635
69KIT0.50618336
70CSNK1G20.46372556
71LYN0.46195746
72CDK40.43878536
73TNK20.43737824
74EIF2AK20.41843010
75AKT20.37982987
76OXSR10.37609977
77LIMK10.35752335
78MAP3K80.35485172
79CAMK10.34545755
80TIE10.33093420
81GRK70.32716369
82TESK10.32033533
83PIK3CA0.31601321
84PLK20.29933855
85HCK0.29369917
86WNK30.28008036
87MARK30.27994057
88PDK20.27238325
89PRKD20.27052322
90ZAP700.27036592
91RPS6KA50.26734527
92OBSCN0.26404966
93ABL20.25728016
94TYK20.25518133
95EGFR0.25391309
96MAPK150.24376190
97PKN10.21697624
98CSNK2A10.21642772
99ADRBK10.21121147
100PRKCA0.20153371

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.04182527
2Primary immunodeficiency_Homo sapiens_hsa053403.54142087
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.26875107
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.84169556
5Caffeine metabolism_Homo sapiens_hsa002322.78169945
6RNA polymerase_Homo sapiens_hsa030202.75598796
7Oxidative phosphorylation_Homo sapiens_hsa001902.32393079
8Allograft rejection_Homo sapiens_hsa053302.21629175
9Ribosome_Homo sapiens_hsa030102.21145911
10Graft-versus-host disease_Homo sapiens_hsa053322.14339080
11Type I diabetes mellitus_Homo sapiens_hsa049402.13566766
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.01665415
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.01276050
14Parkinsons disease_Homo sapiens_hsa050121.82570498
15Antigen processing and presentation_Homo sapiens_hsa046121.81815570
16Sulfur metabolism_Homo sapiens_hsa009201.76303249
17Protein export_Homo sapiens_hsa030601.73710427
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.62880224
19T cell receptor signaling pathway_Homo sapiens_hsa046601.61654964
20Hematopoietic cell lineage_Homo sapiens_hsa046401.57466505
21Autoimmune thyroid disease_Homo sapiens_hsa053201.55363086
22Basal transcription factors_Homo sapiens_hsa030221.52718195
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48771684
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44850464
25Nitrogen metabolism_Homo sapiens_hsa009101.43951452
26Huntingtons disease_Homo sapiens_hsa050161.43662840
27RNA degradation_Homo sapiens_hsa030181.38548565
28Base excision repair_Homo sapiens_hsa034101.33279112
29Chemical carcinogenesis_Homo sapiens_hsa052041.30662834
30Pyrimidine metabolism_Homo sapiens_hsa002401.29026760
31Rheumatoid arthritis_Homo sapiens_hsa053231.27928048
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24602393
33Malaria_Homo sapiens_hsa051441.24533537
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22737935
35Alzheimers disease_Homo sapiens_hsa050101.22456488
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.22147008
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17423264
38Spliceosome_Homo sapiens_hsa030401.17063367
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.16840972
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.16455779
41Linoleic acid metabolism_Homo sapiens_hsa005911.16323978
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14826355
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.11690846
44Measles_Homo sapiens_hsa051621.10048132
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08719513
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07860691
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.07282368
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00533629
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98638531
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98033094
51Retinol metabolism_Homo sapiens_hsa008300.93731994
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90587410
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86685254
54Phototransduction_Homo sapiens_hsa047440.86638841
55Regulation of autophagy_Homo sapiens_hsa041400.85876635
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84146611
57Purine metabolism_Homo sapiens_hsa002300.83188077
58TNF signaling pathway_Homo sapiens_hsa046680.81080066
59Tryptophan metabolism_Homo sapiens_hsa003800.80819223
60Cardiac muscle contraction_Homo sapiens_hsa042600.80467844
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78349846
62Herpes simplex infection_Homo sapiens_hsa051680.77802282
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76250587
64Asthma_Homo sapiens_hsa053100.76075065
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71748483
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.71102915
67Glycerolipid metabolism_Homo sapiens_hsa005610.70638926
68African trypanosomiasis_Homo sapiens_hsa051430.69571947
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68908276
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67260296
71Propanoate metabolism_Homo sapiens_hsa006400.66727937
72ABC transporters_Homo sapiens_hsa020100.65136247
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65125185
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.61345060
75Peroxisome_Homo sapiens_hsa041460.61216452
76Fat digestion and absorption_Homo sapiens_hsa049750.60224717
77One carbon pool by folate_Homo sapiens_hsa006700.58010263
78Viral myocarditis_Homo sapiens_hsa054160.57235918
79Epstein-Barr virus infection_Homo sapiens_hsa051690.55437280
80Non-homologous end-joining_Homo sapiens_hsa034500.54025306
81Arachidonic acid metabolism_Homo sapiens_hsa005900.52218254
82Nicotine addiction_Homo sapiens_hsa050330.50653574
83Folate biosynthesis_Homo sapiens_hsa007900.49885551
84Sphingolipid metabolism_Homo sapiens_hsa006000.49220670
85Apoptosis_Homo sapiens_hsa042100.48456631
86Metabolic pathways_Homo sapiens_hsa011000.48345905
87RNA transport_Homo sapiens_hsa030130.44414320
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38115093
89Nucleotide excision repair_Homo sapiens_hsa034200.38112639
90Salivary secretion_Homo sapiens_hsa049700.37125807
91Butanoate metabolism_Homo sapiens_hsa006500.35919240
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.35880781
93Homologous recombination_Homo sapiens_hsa034400.33071032
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32617238
95Vitamin digestion and absorption_Homo sapiens_hsa049770.32375521
96p53 signaling pathway_Homo sapiens_hsa041150.30373501
97Shigellosis_Homo sapiens_hsa051310.28005283
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27129398
99Phenylalanine metabolism_Homo sapiens_hsa003600.26970130
100Systemic lupus erythematosus_Homo sapiens_hsa053220.25289624

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