ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	folic acid-containing compound biosynthetic process (GO:0009396)	8.07552750
2	purine nucleotide salvage (GO:0032261)	6.99158930
3	homocysteine metabolic process (GO:0050667)	6.21429782
4	regulation of plasminogen activation (GO:0010755)	6.19716464
5	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	6.16828198
6	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	6.16828198
7	pteridine-containing compound biosynthetic process (GO:0042559)	5.48714613
8	regulation of gonadotropin secretion (GO:0032276)	5.46928461
9	protein-cofactor linkage (GO:0018065)	5.35937967
10	sulfur amino acid catabolic process (GO:0000098)	5.32286377
11	mitochondrial RNA metabolic process (GO:0000959)	5.06487299
12	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	4.80802257
13	adenosine metabolic process (GO:0046085)	4.80754926
14	platelet dense granule organization (GO:0060155)	4.60173911
15	IMP biosynthetic process (GO:0006188)	4.59746364
16	GMP metabolic process (GO:0046037)	4.52523465
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.37762887
18	NADH dehydrogenase complex assembly (GO:0010257)	4.37762887
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.37762887
20	negative regulation of DNA biosynthetic process (GO:2000279)	4.30207696
21	alternative mRNA splicing, via spliceosome (GO:0000380)	4.26007477
22	cysteine metabolic process (GO:0006534)	4.20452180
23	pseudouridine synthesis (GO:0001522)	4.17208356
24	metallo-sulfur cluster assembly (GO:0031163)	4.10126534
25	iron-sulfur cluster assembly (GO:0016226)	4.10126534
26	tetrahydrofolate metabolic process (GO:0046653)	4.09890864
27	folic acid-containing compound metabolic process (GO:0006760)	4.06131692
28	protein-chromophore linkage (GO:0018298)	3.79104532
29	purine-containing compound salvage (GO:0043101)	3.75203285
30	ribosome biogenesis (GO:0042254)	3.75092469
31	microtubule nucleation (GO:0007020)	3.72718791
32	protein complex biogenesis (GO:0070271)	3.71988673
33	proteasome assembly (GO:0043248)	3.71193290
34	DNA deamination (GO:0045006)	3.70759268
35	rRNA modification (GO:0000154)	3.62536891
36	nucleotide salvage (GO:0043173)	3.62455867
37	protein deneddylation (GO:0000338)	3.61016390
38	IMP metabolic process (GO:0046040)	3.60591648
39	tRNA modification (GO:0006400)	3.58294894
40	cullin deneddylation (GO:0010388)	3.46734539
41	galactose catabolic process (GO:0019388)	3.44427534
42	desmosome organization (GO:0002934)	3.43725124
43	positive regulation of endothelial cell differentiation (GO:0045603)	3.41087727
44	GPI anchor biosynthetic process (GO:0006506)	3.38568275
45	pteridine-containing compound metabolic process (GO:0042558)	3.37848611
46	organic cation transport (GO:0015695)	3.36125757
47	mitochondrial respiratory chain complex assembly (GO:0033108)	3.35136539
48	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	3.34952780
49	cytidine metabolic process (GO:0046087)	3.34113413
50	cytidine catabolic process (GO:0006216)	3.34113413
51	cytidine deamination (GO:0009972)	3.34113413
52	regulation of vitamin D biosynthetic process (GO:0060556)	3.27156862
53	rRNA methylation (GO:0031167)	3.26850559
54	aldehyde catabolic process (GO:0046185)	3.24031565
55	polyamine biosynthetic process (GO:0006596)	3.23232514
56	one-carbon metabolic process (GO:0006730)	3.21208050
57	white fat cell differentiation (GO:0050872)	3.20859068
58	serine family amino acid biosynthetic process (GO:0009070)	3.19774071
59	sulfur amino acid biosynthetic process (GO:0000097)	3.19232314
60	galactose metabolic process (GO:0006012)	3.19197579
61	inner mitochondrial membrane organization (GO:0007007)	3.16253441
62	response to gravity (GO:0009629)	3.13527558
63	L-serine metabolic process (GO:0006563)	3.11468414
64	negative regulation of Ras GTPase activity (GO:0034261)	3.10009623
65	guanosine-containing compound biosynthetic process (GO:1901070)	3.04875471
66	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.03123548
67	GPI anchor metabolic process (GO:0006505)	3.02458151
68	cartilage morphogenesis (GO:0060536)	3.02037135
69	primary amino compound metabolic process (GO:1901160)	3.00032440
70	negative regulation of telomerase activity (GO:0051974)	2.99381099
71	transcription from mitochondrial promoter (GO:0006390)	2.97872934
72	folic acid metabolic process (GO:0046655)	2.97306393
73	purine nucleobase biosynthetic process (GO:0009113)	2.91495169
74	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.91086278
75	polyamine metabolic process (GO:0006595)	2.90807753
76	tRNA processing (GO:0008033)	2.90656845
77	positive regulation of hair follicle development (GO:0051798)	2.87639779
78	positive regulation of hair cycle (GO:0042635)	2.87639779
79	regulation of vitamin metabolic process (GO:0030656)	2.85592714
80	cochlea development (GO:0090102)	2.81548389
81	viral mRNA export from host cell nucleus (GO:0046784)	2.76022408
82	cellular component biogenesis (GO:0044085)	2.74410302
83	regulation of endothelial cell differentiation (GO:0045601)	2.73360252
84	aminoglycoside antibiotic metabolic process (GO:0030647)	2.71521308
85	RNA modification (GO:0009451)	2.70363521
86	fucose catabolic process (GO:0019317)	2.66225446
87	L-fucose metabolic process (GO:0042354)	2.66225446
88	L-fucose catabolic process (GO:0042355)	2.66225446
89	regulation of sequestering of triglyceride (GO:0010889)	2.62162855
90	peptidyl-histidine modification (GO:0018202)	2.61595392
91	serine family amino acid catabolic process (GO:0009071)	2.60943162
92	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.58426651
93	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.58371193
94	placenta development (GO:0001890)	2.55601793
95	DNA replication-dependent nucleosome organization (GO:0034723)	2.54552286
96	DNA replication-dependent nucleosome assembly (GO:0006335)	2.54552286
97	rRNA metabolic process (GO:0016072)	2.53271328
98	rRNA processing (GO:0006364)	2.53170322
99	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.53099725
100	ATP synthesis coupled proton transport (GO:0015986)	2.53099725

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	9.51065684
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.03207909
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.78288489
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.57980896
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.43757485
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.41606966
7	VDR_22108803_ChIP-Seq_LS180_Human	3.32244417
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.04630578
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.98530302
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.90286792
11	FOXP3_21729870_ChIP-Seq_TREG_Human	2.38829977
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.34594020
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.29884985
14	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.26275541
15	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.17936603
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.12186454
17	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.05054676
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.96049803
19	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.89931154
20	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.88959944
21	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.84921194
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.84854217
23	STAT1_20625510_ChIP-Seq_HELA_Human	1.72671964
24	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.71967074
25	ZNF274_21170338_ChIP-Seq_K562_Hela	1.70566645
26	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.63526366
27	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.61236503
28	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.60117446
29	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.59634338
30	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.56700718
31	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.52820442
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.51435401
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.50581543
34	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.50530276
35	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.46182748
36	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.37318674
37	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.35453593
38	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.30736468
39	ELK1_19687146_ChIP-ChIP_HELA_Human	1.30628131
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.29592446
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.28783961
42	FUS_26573619_Chip-Seq_HEK293_Human	1.26184661
43	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.22616892
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.22072978
45	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.21481122
46	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.21130956
47	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.19145756
48	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.18910578
49	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.16648391
50	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.16414819
51	E2F7_22180533_ChIP-Seq_HELA_Human	1.16338943
52	P300_27268052_Chip-Seq_Bcells_Human	1.15634668
53	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13332859
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13332859
55	NCOR_22424771_ChIP-Seq_293T_Human	1.13036013
56	TTF2_22483619_ChIP-Seq_HELA_Human	1.12846840
57	CDX2_22108803_ChIP-Seq_LS180_Human	1.12055936
58	EWS_26573619_Chip-Seq_HEK293_Human	1.11343266
59	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.06536634
60	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.05827499
61	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.03913846
62	GATA3_26560356_Chip-Seq_TH2_Human	1.03785616
63	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03149274
64	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.03082627
65	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.02967289
66	XRN2_22483619_ChIP-Seq_HELA_Human	1.02283359
67	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.01652100
68	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98699071
69	MYB_26560356_Chip-Seq_TH2_Human	0.97286579
70	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.97197201
71	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.96666632
72	MYC_18940864_ChIP-ChIP_HL60_Human	0.94934171
73	TAF2_19829295_ChIP-Seq_ESCs_Human	0.93384381
74	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.92009575
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91672181
76	ER_23166858_ChIP-Seq_MCF-7_Human	0.91375958
77	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.91184584
78	AR_20517297_ChIP-Seq_VCAP_Human	0.90174522
79	ERG_20517297_ChIP-Seq_VCAP_Human	0.89985040
80	CIITA_25753668_ChIP-Seq_RAJI_Human	0.89736807
81	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.89285144
82	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.87509466
83	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.86577495
84	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.86309208
85	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.86239179
86	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.86018615
87	NANOG_20526341_ChIP-Seq_ESCs_Human	0.84945208
88	P300_19829295_ChIP-Seq_ESCs_Human	0.84849726
89	GATA3_26560356_Chip-Seq_TH1_Human	0.84371239
90	OCT4_20526341_ChIP-Seq_ESCs_Human	0.83673264
91	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.83079168
92	P53_21459846_ChIP-Seq_SAOS-2_Human	0.83053487
93	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.83047729
94	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.82673152
95	ZNF263_19887448_ChIP-Seq_K562_Human	0.80278153
96	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.79680665
97	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.79237934
98	ETS1_21867929_ChIP-Seq_TH2_Mouse	0.78543976
99	SPI1_23547873_ChIP-Seq_NB4_Human	0.77634895
100	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.77179764

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005646_abnormal_pituitary_gland	5.08373691
2	MP0000013_abnormal_adipose_tissue	3.91999260
3	MP0008995_early_reproductive_senescence	3.88968607
4	MP0005670_abnormal_white_adipose	3.63995630
5	MP0003724_increased_susceptibility_to	3.52869379
6	MP0005360_urolithiasis	3.20798676
7	MP0002163_abnormal_gland_morphology	2.90383519
8	MP0003806_abnormal_nucleotide_metabolis	2.76606687
9	MP0005645_abnormal_hypothalamus_physiol	2.73987270
10	MP0004147_increased_porphyrin_level	2.70190984
11	MP0002736_abnormal_nociception_after	2.33474989
12	MP0002138_abnormal_hepatobiliary_system	2.22691555
13	MP0005671_abnormal_response_to	2.18369161
14	MP0002938_white_spotting	2.17988093
15	MP0008058_abnormal_DNA_repair	2.05622693
16	MP0004885_abnormal_endolymph	2.03499069
17	MP0001661_extended_life_span	2.00706755
18	MP0008872_abnormal_physiological_respon	1.99174931
19	MP0003786_premature_aging	1.92498041
20	MP0003787_abnormal_imprinting	1.92306853
21	MP0002102_abnormal_ear_morphology	1.79536416
22	MP0001764_abnormal_homeostasis	1.78842792
23	MP0008875_abnormal_xenobiotic_pharmacok	1.67148282
24	MP0001968_abnormal_touch/_nociception	1.66942788
25	MP0003183_abnormal_peptide_metabolism	1.62502069
26	MP0000516_abnormal_urinary_system	1.59739112
27	MP0005367_renal/urinary_system_phenotyp	1.59739112
28	MP0000372_irregular_coat_pigmentation	1.54565050
29	MP0000647_abnormal_sebaceous_gland	1.48898579
30	MP0003878_abnormal_ear_physiology	1.42113109
31	MP0005377_hearing/vestibular/ear_phenot	1.42113109
32	MP0005332_abnormal_amino_acid	1.41560624
33	MP0004043_abnormal_pH_regulation	1.40920739
34	MP0009764_decreased_sensitivity_to	1.38238081
35	MP0005084_abnormal_gallbladder_morpholo	1.37684806
36	MP0006276_abnormal_autonomic_nervous	1.35853426
37	MP0006292_abnormal_olfactory_placode	1.31510187
38	MP0002876_abnormal_thyroid_physiology	1.25354646
39	MP0002148_abnormal_hypersensitivity_rea	1.23706521
40	MP0002139_abnormal_hepatobiliary_system	1.22187996
41	MP0005379_endocrine/exocrine_gland_phen	1.20661729
42	MP0000631_abnormal_neuroendocrine_gland	1.20417799
43	MP0000003_abnormal_adipose_tissue	1.17760157
44	MP0003186_abnormal_redox_activity	1.17141451
45	MP0002735_abnormal_chemical_nociception	1.14605294
46	MP0006072_abnormal_retinal_apoptosis	1.14026237
47	MP0005551_abnormal_eye_electrophysiolog	1.12170049
48	MP0004947_skin_inflammation	1.09411379
49	MP0001984_abnormal_olfaction	1.06585515
50	MP0001502_abnormal_circadian_rhythm	1.06082888
51	MP0002277_abnormal_respiratory_mucosa	1.02919508
52	MP0001800_abnormal_humoral_immune	1.02088034
53	MP0005636_abnormal_mineral_homeostasis	1.01391785
54	MP0000534_abnormal_ureter_morphology	0.97632721
55	MP0005085_abnormal_gallbladder_physiolo	0.97522987
56	MP0009643_abnormal_urine_homeostasis	0.97494846
57	MP0005164_abnormal_response_to	0.96650356
58	MP0009046_muscle_twitch	0.94801676
59	MP0002006_tumorigenesis	0.93508343
60	MP0003718_maternal_effect	0.91366112
61	MP0005000_abnormal_immune_tolerance	0.88142809
62	MP0001986_abnormal_taste_sensitivity	0.86840720
63	MP0003436_decreased_susceptibility_to	0.85915637
64	MP0005253_abnormal_eye_physiology	0.84033165
65	MP0001119_abnormal_female_reproductive	0.83337231
66	MP0001919_abnormal_reproductive_system	0.81341605
67	MP0003880_abnormal_central_pattern	0.80023922
68	MP0002733_abnormal_thermal_nociception	0.78756707
69	MP0002723_abnormal_immune_serum	0.78314409
70	MP0005389_reproductive_system_phenotype	0.78258055
71	MP0000750_abnormal_muscle_regeneration	0.76771169
72	MP0008469_abnormal_protein_level	0.76507208
73	MP0000613_abnormal_salivary_gland	0.74814098
74	MP0001905_abnormal_dopamine_level	0.74483902
75	MP0000383_abnormal_hair_follicle	0.74234642
76	MP0005319_abnormal_enzyme/_coenzyme	0.74200019
77	MP0004133_heterotaxia	0.74021143
78	MP0001845_abnormal_inflammatory_respons	0.71852139
79	MP0009785_altered_susceptibility_to	0.71617296
80	MP0002452_abnormal_antigen_presenting	0.71022062
81	MP0001765_abnormal_ion_homeostasis	0.70595750
82	MP0003936_abnormal_reproductive_system	0.70571224
83	MP0009697_abnormal_copulation	0.69578733
84	MP0000747_muscle_weakness	0.68830597
85	MP0003646_muscle_fatigue	0.67792682
86	MP0002396_abnormal_hematopoietic_system	0.67601524
87	MP0002160_abnormal_reproductive_system	0.67335056
88	MP0002095_abnormal_skin_pigmentation	0.64666481
89	MP0000639_abnormal_adrenal_gland	0.64175652
90	MP0001819_abnormal_immune_cell	0.63982871
91	MP0002420_abnormal_adaptive_immunity	0.63689644
92	MP0002132_abnormal_respiratory_system	0.63669038
93	MP0005376_homeostasis/metabolism_phenot	0.63296514
94	MP0006035_abnormal_mitochondrial_morpho	0.63120255
95	MP0000703_abnormal_thymus_morphology	0.62901210
96	MP0000627_abnormal_mammary_gland	0.62884125
97	MP0001756_abnormal_urination	0.62561247
98	MP0008873_increased_physiological_sensi	0.62506363
99	MP0001881_abnormal_mammary_gland	0.62065694
100	MP0003638_abnormal_response/metabolism_	0.61557313

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	7.95096384
2	Hyperalaninemia (HP:0003348)	7.95096384
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	7.95096384
4	Constricted visual fields (HP:0001133)	6.33329738
5	Decreased electroretinogram (ERG) amplitude (HP:0000654)	4.34099646
6	Attenuation of retinal blood vessels (HP:0007843)	4.03768052
7	Congenital sensorineural hearing impairment (HP:0008527)	3.90231722
8	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.74852792
9	Spontaneous hematomas (HP:0007420)	3.55665422
10	Chronic otitis media (HP:0000389)	3.40290460
11	Abnormality of serum amino acid levels (HP:0003112)	3.31143369
12	Esophageal varix (HP:0002040)	3.17823936
13	Homocystinuria (HP:0002156)	3.00502561
14	Abnormality of homocysteine metabolism (HP:0010919)	3.00502561
15	Tetany (HP:0001281)	2.96631665
16	Abnormal umbilical cord blood vessels (HP:0011403)	2.92294032
17	Single umbilical artery (HP:0001195)	2.92294032
18	Abnormality of the fetal cardiovascular system (HP:0010948)	2.92294032
19	Abolished electroretinogram (ERG) (HP:0000550)	2.86253418
20	Brittle hair (HP:0002299)	2.83825020
21	Pigmentary retinal degeneration (HP:0001146)	2.81534916
22	Hyperuricemia (HP:0002149)	2.81472239
23	Increased purine levels (HP:0004368)	2.81472239
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.77325918
25	Anorexia (HP:0002039)	2.64464879
26	Poor speech (HP:0002465)	2.62091620
27	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.56328088
28	Elevated erythrocyte sedimentation rate (HP:0003565)	2.54461145
29	Patchy hypopigmentation of hair (HP:0011365)	2.53586498
30	White forelock (HP:0002211)	2.52620948
31	Chorioretinal atrophy (HP:0000533)	2.50517821
32	Abnormality of purine metabolism (HP:0004352)	2.48359018
33	Pulmonary embolism (HP:0002204)	2.45463330
34	Hypoplasia of the uterus (HP:0000013)	2.40548193
35	Hypomagnesemia (HP:0002917)	2.36976207
36	Aplasia/hypoplasia of the uterus (HP:0008684)	2.35018577
37	Hyperglycinemia (HP:0002154)	2.33602091
38	Reduced antithrombin III activity (HP:0001976)	2.32991467
39	Decreased subcutaneous fat (HP:0001002)	2.30982212
40	Increased serum pyruvate (HP:0003542)	2.27845778
41	Heterochromia iridis (HP:0001100)	2.23888741
42	Cortical visual impairment (HP:0100704)	2.23507853
43	Pendular nystagmus (HP:0012043)	2.19455363
44	Conjunctival telangiectasia (HP:0000524)	2.18467148
45	Increased serum lactate (HP:0002151)	2.16109852
46	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.15823781
47	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.14206465
48	Myopathic facies (HP:0002058)	2.11763643
49	Chronic hepatic failure (HP:0100626)	2.09942954
50	Abnormality of the pons (HP:0007361)	2.08374751
51	Oligomenorrhea (HP:0000876)	2.06482541
52	Abnormality of dental color (HP:0011073)	2.05516195
53	Lactic acidosis (HP:0003128)	2.04700540
54	Methylmalonic acidemia (HP:0002912)	2.03106511
55	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.02935370
56	Conjugated hyperbilirubinemia (HP:0002908)	2.02270755
57	True hermaphroditism (HP:0010459)	1.97985901
58	Mitochondrial inheritance (HP:0001427)	1.97544189
59	Potter facies (HP:0002009)	1.95585078
60	Facial shape deformation (HP:0011334)	1.95585078
61	IgG deficiency (HP:0004315)	1.95078918
62	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.92624943
63	Abnormality of DNA repair (HP:0003254)	1.92507926
64	Pancreatic fibrosis (HP:0100732)	1.92363545
65	Abnormal respiratory epithelium morphology (HP:0012253)	1.91759701
66	Abnormal respiratory motile cilium morphology (HP:0005938)	1.91759701
67	Granulocytopenia (HP:0001913)	1.91478300
68	Abnormality of glycolysis (HP:0004366)	1.91253575
69	Arthropathy (HP:0003040)	1.88781310
70	Birth length less than 3rd percentile (HP:0003561)	1.87663634
71	Myocardial infarction (HP:0001658)	1.83168411
72	Abnormality of nucleobase metabolism (HP:0010932)	1.82944545
73	Abnormality of the renal collecting system (HP:0004742)	1.82868440
74	Thrombophlebitis (HP:0004418)	1.82773910
75	Optic disc pallor (HP:0000543)	1.82217092
76	Abnormality of subcutaneous fat tissue (HP:0001001)	1.80913342
77	Insulin-resistant diabetes mellitus (HP:0000831)	1.80282449
78	Abnormality of magnesium homeostasis (HP:0004921)	1.79512361
79	Recurrent corneal erosions (HP:0000495)	1.79336518
80	Maternal diabetes (HP:0009800)	1.79234512
81	Hypoplastic left heart (HP:0004383)	1.77337605
82	Orthostatic hypotension (HP:0001278)	1.76061669
83	Biconcave vertebral bodies (HP:0004586)	1.76038001
84	Methylmalonic aciduria (HP:0012120)	1.75284986
85	Short tibia (HP:0005736)	1.74395770
86	Hyperphosphaturia (HP:0003109)	1.73176832
87	Hypoalphalipoproteinemia (HP:0003233)	1.72803194
88	Type II diabetes mellitus (HP:0005978)	1.72269244
89	Chronic sinusitis (HP:0011109)	1.71094039
90	Hypergonadotropic hypogonadism (HP:0000815)	1.70859349
91	Abnormality of eosinophils (HP:0001879)	1.70081419
92	Duplicated collecting system (HP:0000081)	1.70042709
93	Chronic diarrhea (HP:0002028)	1.69956716
94	Type II lissencephaly (HP:0007260)	1.68515897
95	Nausea (HP:0002018)	1.68329522
96	Type 2 muscle fiber atrophy (HP:0003554)	1.67396495
97	Increased CSF lactate (HP:0002490)	1.67144979
98	Acute necrotizing encephalopathy (HP:0006965)	1.67101966
99	Generalized aminoaciduria (HP:0002909)	1.66768731
100	Pustule (HP:0200039)	1.65148667

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	6.92059373
2	TLK1	6.68278182
3	MAP4K2	4.25775871
4	VRK1	2.56613937
5	BCKDK	2.46869804
6	MAP2K3	2.32755999
7	LMTK2	2.29241480
8	VRK2	2.26826399
9	TAOK3	2.17357616
10	MAP3K3	2.00150838
11	MST4	1.96051910
12	TNK2	1.81843067
13	RPS6KB2	1.75957222
14	TSSK6	1.71113437
15	NME2	1.64484402
16	MAP4K1	1.61404506
17	ADRBK2	1.43897187
18	CDK8	1.33850031
19	NTRK2	1.29624133
20	MAPKAPK5	1.24977152
21	JAK3	1.22345183
22	CDK9	1.21879829
23	NTRK1	1.19285885
24	FGR	1.11590258
25	IKBKB	1.06939747
26	MAPKAPK3	1.06884210
27	MKNK1	1.06505770
28	CSNK1G3	0.94699654
29	CSNK1G1	0.94360737
30	SRPK1	0.94280064
31	ADRBK1	0.92214385
32	ACVR1B	0.91265603
33	CSNK1A1L	0.90492632
34	RPS6KA5	0.85323809
35	SGK494	0.85192022
36	SGK223	0.85192022
37	ABL2	0.84902571
38	EIF2AK3	0.84725913
39	SCYL2	0.84222042
40	PHKG2	0.82795805
41	PHKG1	0.82795805
42	IKBKE	0.82614861
43	MATK	0.78490313
44	SGK2	0.78256415
45	TXK	0.75625566
46	DYRK2	0.75090030
47	CSNK1A1	0.73006288
48	GRK1	0.71412792
49	AURKA	0.71112310
50	SYK	0.69711343
51	BUB1	0.68738605
52	TIE1	0.68361571
53	TNIK	0.67528223
54	PIM1	0.66403039
55	DAPK2	0.65726815
56	PRKCQ	0.65236584
57	NTRK3	0.62146206
58	KDR	0.61969690
59	NEK6	0.61691596
60	NUAK1	0.60623401
61	TRPM7	0.60403660
62	MAP2K1	0.58091325
63	PKN1	0.56825498
64	MAP3K14	0.56211438
65	CSNK1G2	0.53596048
66	GRK6	0.50811394
67	OBSCN	0.49956615
68	MAPK13	0.48839052
69	PLK3	0.48418442
70	BMPR1B	0.47335198
71	PRKG2	0.47065859
72	PRKD3	0.46854209
73	CDK7	0.46481059
74	PDK2	0.46084681
75	GRK7	0.45318757
76	AKT2	0.44852594
77	EPHB2	0.43788910
78	EPHA2	0.40256721
79	FES	0.39308990
80	RIPK1	0.37604883
81	ITK	0.37484592
82	ALK	0.37211275
83	EPHA3	0.36532138
84	EIF2AK2	0.35802749
85	INSRR	0.35644808
86	CSNK2A1	0.35641782
87	RPS6KA4	0.34238395
88	INSR	0.33980089
89	RPS6KB1	0.33504256
90	CCNB1	0.33276540
91	TRIM28	0.32761070
92	SGK3	0.32087216
93	GRK5	0.31194867
94	PRKCA	0.31106710
95	ATR	0.30410976
96	TAF1	0.30383279
97	OXSR1	0.30000036
98	KIT	0.29872767
99	LYN	0.27496219
100	TEC	0.26949866

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	One carbon pool by folate_Homo sapiens_hsa00670	4.87123196
2	Proteasome_Homo sapiens_hsa03050	3.26933152
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.65520075
4	Sulfur relay system_Homo sapiens_hsa04122	2.52948011
5	Sulfur metabolism_Homo sapiens_hsa00920	2.44589867
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.30081055
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.28199570
8	Basal transcription factors_Homo sapiens_hsa03022	2.01166285
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.99765024
10	RNA polymerase_Homo sapiens_hsa03020	1.98971524
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.92815420
12	Ribosome_Homo sapiens_hsa03010	1.88517089
13	Collecting duct acid secretion_Homo sapiens_hsa04966	1.86192832
14	Spliceosome_Homo sapiens_hsa03040	1.84969119
15	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.82110423
16	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.76010702
17	Parkinsons disease_Homo sapiens_hsa05012	1.72315810
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.68931358
19	RNA degradation_Homo sapiens_hsa03018	1.67113365
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.61445152
21	Arginine biosynthesis_Homo sapiens_hsa00220	1.59672571
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.55260080
23	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.54071143
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.45556588
25	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.45411247
26	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.44249384
27	Asthma_Homo sapiens_hsa05310	1.40102589
28	Base excision repair_Homo sapiens_hsa03410	1.29184716
29	Regulation of autophagy_Homo sapiens_hsa04140	1.27278713
30	Folate biosynthesis_Homo sapiens_hsa00790	1.21442431
31	Homologous recombination_Homo sapiens_hsa03440	1.21229881
32	Graft-versus-host disease_Homo sapiens_hsa05332	1.20540607
33	Protein export_Homo sapiens_hsa03060	1.18538916
34	Peroxisome_Homo sapiens_hsa04146	1.17032298
35	RNA transport_Homo sapiens_hsa03013	1.15554818
36	Nucleotide excision repair_Homo sapiens_hsa03420	1.15358305
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.09054849
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.08954758
39	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.07965066
40	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.07476530
41	Propanoate metabolism_Homo sapiens_hsa00640	1.05497685
42	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.04566153
43	Morphine addiction_Homo sapiens_hsa05032	1.01739158
44	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.00551468
45	Huntingtons disease_Homo sapiens_hsa05016	1.00104756
46	Retinol metabolism_Homo sapiens_hsa00830	0.97340452
47	Alzheimers disease_Homo sapiens_hsa05010	0.97295656
48	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.96386461
49	Type I diabetes mellitus_Homo sapiens_hsa04940	0.95041890
50	Phototransduction_Homo sapiens_hsa04744	0.94961377
51	Antigen processing and presentation_Homo sapiens_hsa04612	0.92889368
52	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.92555843
53	Galactose metabolism_Homo sapiens_hsa00052	0.91533861
54	Rheumatoid arthritis_Homo sapiens_hsa05323	0.90823170
55	Allograft rejection_Homo sapiens_hsa05330	0.90018254
56	Purine metabolism_Homo sapiens_hsa00230	0.88291636
57	DNA replication_Homo sapiens_hsa03030	0.86940008
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.85486769
59	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.85363156
60	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.84643600
61	Alcoholism_Homo sapiens_hsa05034	0.84543416
62	GABAergic synapse_Homo sapiens_hsa04727	0.81961817
63	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.81480134
64	Other glycan degradation_Homo sapiens_hsa00511	0.79932375
65	Vibrio cholerae infection_Homo sapiens_hsa05110	0.79229386
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.78490699
67	Mismatch repair_Homo sapiens_hsa03430	0.77810413
68	Pyrimidine metabolism_Homo sapiens_hsa00240	0.77258933
69	Nicotine addiction_Homo sapiens_hsa05033	0.75646097
70	Linoleic acid metabolism_Homo sapiens_hsa00591	0.66163680
71	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.65918717
72	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.62776661
73	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.62017364
74	Serotonergic synapse_Homo sapiens_hsa04726	0.60218926
75	Metabolic pathways_Homo sapiens_hsa01100	0.59763818
76	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.57113586
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56958771
78	Olfactory transduction_Homo sapiens_hsa04740	0.55736538
79	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.55070392
80	Butanoate metabolism_Homo sapiens_hsa00650	0.53648944
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.53093594
82	Renin-angiotensin system_Homo sapiens_hsa04614	0.51480009
83	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.50224028
84	Caffeine metabolism_Homo sapiens_hsa00232	0.50007593
85	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49742491
86	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.49167042
87	Circadian entrainment_Homo sapiens_hsa04713	0.48991142
88	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.48795437
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.46651430
90	Tryptophan metabolism_Homo sapiens_hsa00380	0.45372428
91	Chemical carcinogenesis_Homo sapiens_hsa05204	0.44632823
92	mRNA surveillance pathway_Homo sapiens_hsa03015	0.42429430
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.41934062
94	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.40803983
95	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.39965972
96	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.38462254
97	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.38046463
98	Legionellosis_Homo sapiens_hsa05134	0.37278809
99	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.36058444
100	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.35979384

HNRNPA1P18

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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