ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	6.59182338
2	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	6.59182338
3	purine nucleotide salvage (GO:0032261)	6.37783213
4	adenosine metabolic process (GO:0046085)	6.24435201
5	folic acid-containing compound biosynthetic process (GO:0009396)	6.16234843
6	indole-containing compound catabolic process (GO:0042436)	6.15843234
7	indolalkylamine catabolic process (GO:0046218)	6.15843234
8	tryptophan catabolic process (GO:0006569)	6.15843234
9	mitochondrial RNA metabolic process (GO:0000959)	6.14219370
10	kynurenine metabolic process (GO:0070189)	6.13844354
11	homocysteine metabolic process (GO:0050667)	6.10800055
12	IMP biosynthetic process (GO:0006188)	5.39157535
13	sulfur amino acid catabolic process (GO:0000098)	5.38629198
14	transcription from mitochondrial promoter (GO:0006390)	5.37676496
15	tryptophan metabolic process (GO:0006568)	5.23323493
16	regulation of plasminogen activation (GO:0010755)	5.15666045
17	DNA double-strand break processing (GO:0000729)	4.99507601
18	non-recombinational repair (GO:0000726)	4.99232712
19	double-strand break repair via nonhomologous end joining (GO:0006303)	4.99232712
20	alternative mRNA splicing, via spliceosome (GO:0000380)	4.85689254
21	IMP metabolic process (GO:0046040)	4.79368288
22	cysteine metabolic process (GO:0006534)	4.62529946
23	rRNA modification (GO:0000154)	4.56011998
24	nucleotide salvage (GO:0043173)	4.38862103
25	L-serine metabolic process (GO:0006563)	4.36967682
26	proteasome assembly (GO:0043248)	4.34621447
27	rRNA methylation (GO:0031167)	4.27008979
28	white fat cell differentiation (GO:0050872)	4.19526291
29	negative regulation of DNA biosynthetic process (GO:2000279)	4.15355293
30	tRNA modification (GO:0006400)	4.14564263
31	cytochrome complex assembly (GO:0017004)	4.11180573
32	pteridine-containing compound biosynthetic process (GO:0042559)	3.93636271
33	water-soluble vitamin biosynthetic process (GO:0042364)	3.93578196
34	indolalkylamine metabolic process (GO:0006586)	3.90747336
35	pseudouridine synthesis (GO:0001522)	3.89066068
36	GMP metabolic process (GO:0046037)	3.74304944
37	protein-cofactor linkage (GO:0018065)	3.70173494
38	protein complex biogenesis (GO:0070271)	3.62595491
39	cellular biogenic amine catabolic process (GO:0042402)	3.58891903
40	amine catabolic process (GO:0009310)	3.58891903
41	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.54674788
42	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.54674788
43	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.54674788
44	respiratory chain complex IV assembly (GO:0008535)	3.50509100
45	platelet dense granule organization (GO:0060155)	3.46749656
46	aromatic amino acid family catabolic process (GO:0009074)	3.45857992
47	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.43592816
48	purine-containing compound salvage (GO:0043101)	3.41578789
49	serine family amino acid biosynthetic process (GO:0009070)	3.39940288
50	inner mitochondrial membrane organization (GO:0007007)	3.37931058
51	microtubule nucleation (GO:0007020)	3.37916628
52	CENP-A containing nucleosome assembly (GO:0034080)	3.37377375
53	tRNA processing (GO:0008033)	3.32999943
54	DNA ligation (GO:0006266)	3.32004733
55	tetrahydrofolate metabolic process (GO:0046653)	3.30670167
56	positive regulation of endothelial cell differentiation (GO:0045603)	3.27212864
57	mitochondrial respiratory chain complex assembly (GO:0033108)	3.25391002
58	folic acid-containing compound metabolic process (GO:0006760)	3.24970530
59	organic cation transport (GO:0015695)	3.23633164
60	mitochondrial DNA replication (GO:0006264)	3.20055378
61	histone exchange (GO:0043486)	3.19451784
62	DNA catabolic process, exonucleolytic (GO:0000738)	3.18092273
63	purine nucleobase biosynthetic process (GO:0009113)	3.16303759
64	protein-chromophore linkage (GO:0018298)	3.16263839
65	chromatin remodeling at centromere (GO:0031055)	3.15418685
66	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.14013512
67	NADH dehydrogenase complex assembly (GO:0010257)	3.11639016
68	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.11639016
69	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.11639016
70	protein deneddylation (GO:0000338)	3.10196581
71	indole-containing compound metabolic process (GO:0042430)	3.09911652
72	mitochondrial DNA metabolic process (GO:0032042)	3.01573658
73	sulfur amino acid biosynthetic process (GO:0000097)	2.97552496
74	serine family amino acid catabolic process (GO:0009071)	2.94266092
75	cochlea development (GO:0090102)	2.91488371
76	cullin deneddylation (GO:0010388)	2.89434599
77	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.88484267
78	benzene-containing compound metabolic process (GO:0042537)	2.87192631
79	dicarboxylic acid biosynthetic process (GO:0043650)	2.86740485
80	RNA modification (GO:0009451)	2.86421122
81	nucleobase biosynthetic process (GO:0046112)	2.86250009
82	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.85432257
83	oxidative phosphorylation (GO:0006119)	2.83740246
84	mRNA splice site selection (GO:0006376)	2.83196736
85	ribosome assembly (GO:0042255)	2.82918068
86	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	2.81815957
87	histone H4-K12 acetylation (GO:0043983)	2.81327889
88	negative regulation of telomerase activity (GO:0051974)	2.80532137
89	negative regulation of mast cell activation (GO:0033004)	2.80381722
90	primary amino compound metabolic process (GO:1901160)	2.74769348
91	regulation of endothelial cell differentiation (GO:0045601)	2.73418393
92	desmosome organization (GO:0002934)	2.70835151
93	kinetochore assembly (GO:0051382)	2.70021708
94	branched-chain amino acid catabolic process (GO:0009083)	2.69016095
95	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.67685608
96	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.65798733
97	guanosine-containing compound biosynthetic process (GO:1901070)	2.61500022
98	acrosome assembly (GO:0001675)	2.60928309
99	NAD biosynthetic process (GO:0009435)	2.60920119
100	tRNA metabolic process (GO:0006399)	2.59646387

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	8.95394244
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.45052733
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.62537937
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.28706002
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.21350477
6	VDR_22108803_ChIP-Seq_LS180_Human	3.17048489
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.97042749
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.64655502
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.58285025
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.56502019
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.51443976
12	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.28468503
13	EWS_26573619_Chip-Seq_HEK293_Human	2.19874161
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.08114934
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.06738591
16	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.00554789
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.96204854
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.93499354
19	FOXP3_21729870_ChIP-Seq_TREG_Human	1.93014955
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.92979971
21	ELK1_19687146_ChIP-ChIP_HELA_Human	1.85089633
22	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.81976410
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.77572292
24	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.75114637
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.63605602
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.63246476
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.58645941
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49407355
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.48171902
30	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.45860885
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.42397479
32	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.41966645
33	FUS_26573619_Chip-Seq_HEK293_Human	1.39919945
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.38052218
35	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.37814825
36	CDX2_22108803_ChIP-Seq_LS180_Human	1.36401073
37	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.32406961
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31355549
39	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.30656327
40	GABP_19822575_ChIP-Seq_HepG2_Human	1.30499469
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.30345128
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28565351
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28565351
44	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28135471
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26009873
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.25017458
47	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.23987388
48	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.22770507
49	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.19783876
50	HOXB7_26014856_ChIP-Seq_BT474_Human	1.19379420
51	AR_20517297_ChIP-Seq_VCAP_Human	1.18036762
52	NCOR_22424771_ChIP-Seq_293T_Human	1.16654017
53	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.15698177
54	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.13965773
55	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.13754991
56	P300_19829295_ChIP-Seq_ESCs_Human	1.13393558
57	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.13133033
58	GATA3_26560356_Chip-Seq_TH1_Human	1.11462155
59	BCAT_22108803_ChIP-Seq_LS180_Human	1.10650515
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09600078
61	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.09047452
62	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.09041185
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08659336
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08659336
65	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.05634759
66	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.04811947
67	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04277010
68	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.03485933
69	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.02274151
70	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.01436006
71	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01384049
72	CEBPB_22108803_ChIP-Seq_LS180_Human	0.99825494
73	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.98710233
74	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.98335312
75	E2F7_22180533_ChIP-Seq_HELA_Human	0.98051731
76	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.97992616
77	GATA3_26560356_Chip-Seq_TH2_Human	0.97852614
78	ERG_20517297_ChIP-Seq_VCAP_Human	0.97615857
79	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.95943187
80	STAT1_20625510_ChIP-Seq_HELA_Human	0.94618148
81	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.94259149
82	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.93987934
83	IRF1_19129219_ChIP-ChIP_H3396_Human	0.93509243
84	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.93296976
85	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.91462190
86	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.90711164
87	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.90546878
88	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.90528511
89	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.89656771
90	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.89603896
91	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.86720302
92	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.86450127
93	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.84391997
94	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.83642318
95	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.82933822
96	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.82573593
97	TCF4_22108803_ChIP-Seq_LS180_Human	0.82090379
98	P53_22387025_ChIP-Seq_ESCs_Mouse	0.81955792
99	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.81490269
100	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.80142713

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	5.21802048
2	MP0005646_abnormal_pituitary_gland	4.30499571
3	MP0001661_extended_life_span	3.55145745
4	MP0005360_urolithiasis	3.43684830
5	MP0004147_increased_porphyrin_level	2.98865543
6	MP0008995_early_reproductive_senescence	2.96996855
7	MP0000013_abnormal_adipose_tissue	2.93656459
8	MP0002736_abnormal_nociception_after	2.83929905
9	MP0000516_abnormal_urinary_system	2.82390837
10	MP0005367_renal/urinary_system_phenotyp	2.82390837
11	MP0003183_abnormal_peptide_metabolism	2.68852195
12	MP0005670_abnormal_white_adipose	2.65967403
13	MP0004885_abnormal_endolymph	2.53490650
14	MP0008058_abnormal_DNA_repair	2.51536616
15	MP0008872_abnormal_physiological_respon	2.49686306
16	MP0002138_abnormal_hepatobiliary_system	2.43035788
17	MP0001968_abnormal_touch/_nociception	2.28289476
18	MP0010094_abnormal_chromosome_stability	2.17700475
19	MP0003806_abnormal_nucleotide_metabolis	2.15498678
20	MP0006072_abnormal_retinal_apoptosis	2.13615083
21	MP0006292_abnormal_olfactory_placode	2.13604819
22	MP0002160_abnormal_reproductive_system	1.97482197
23	MP0001764_abnormal_homeostasis	1.94070961
24	MP0002938_white_spotting	1.93611212
25	MP0003724_increased_susceptibility_to	1.85202316
26	MP0003186_abnormal_redox_activity	1.80298962
27	MP0009697_abnormal_copulation	1.77473487
28	MP0005083_abnormal_biliary_tract	1.67421294
29	MP0003252_abnormal_bile_duct	1.65192194
30	MP0005332_abnormal_amino_acid	1.62596278
31	MP0005389_reproductive_system_phenotype	1.59110498
32	MP0005551_abnormal_eye_electrophysiolog	1.55065561
33	MP0005253_abnormal_eye_physiology	1.54789470
34	MP0005167_abnormal_blood-brain_barrier	1.51523487
35	MP0003786_premature_aging	1.50467066
36	MP0002095_abnormal_skin_pigmentation	1.49909497
37	MP0005671_abnormal_response_to	1.45069227
38	MP0005085_abnormal_gallbladder_physiolo	1.43596161
39	MP0008775_abnormal_heart_ventricle	1.40320756
40	MP0001919_abnormal_reproductive_system	1.32500507
41	MP0002006_tumorigenesis	1.27841381
42	MP0004043_abnormal_pH_regulation	1.23482431
43	MP0003693_abnormal_embryo_hatching	1.21338638
44	MP0001835_abnormal_antigen_presentation	1.15738620
45	MP0005647_abnormal_sex_gland	1.12393062
46	MP0001800_abnormal_humoral_immune	1.10944760
47	MP0009384_cardiac_valve_regurgitation	1.05843440
48	MP0003718_maternal_effect	1.03859306
49	MP0005636_abnormal_mineral_homeostasis	1.01675973
50	MP0002148_abnormal_hypersensitivity_rea	1.00927110
51	MP0009333_abnormal_splenocyte_physiolog	0.98815268
52	MP0000653_abnormal_sex_gland	0.96948868
53	MP0002396_abnormal_hematopoietic_system	0.96272656
54	MP0002210_abnormal_sex_determination	0.96225276
55	MP0000631_abnormal_neuroendocrine_gland	0.94702077
56	MP0003111_abnormal_nucleus_morphology	0.92063261
57	MP0001145_abnormal_male_reproductive	0.89485151
58	MP0009643_abnormal_urine_homeostasis	0.88830927
59	MP0005645_abnormal_hypothalamus_physiol	0.88398735
60	MP0002166_altered_tumor_susceptibility	0.86842001
61	MP0003638_abnormal_response/metabolism_	0.85585313
62	MP0000647_abnormal_sebaceous_gland	0.85255814
63	MP0002837_dystrophic_cardiac_calcinosis	0.79042111
64	MP0003763_abnormal_thymus_physiology	0.78980746
65	MP0001119_abnormal_female_reproductive	0.78030752
66	MP0002282_abnormal_trachea_morphology	0.77269183
67	MP0001929_abnormal_gametogenesis	0.76699983
68	MP0005084_abnormal_gallbladder_morpholo	0.76362230
69	MP0008877_abnormal_DNA_methylation	0.76177576
70	MP0001905_abnormal_dopamine_level	0.75910408
71	MP0005410_abnormal_fertilization	0.75817076
72	MP0005365_abnormal_bile_salt	0.75242408
73	MP0003698_abnormal_male_reproductive	0.74872918
74	MP0000230_abnormal_systemic_arterial	0.72984502
75	MP0004084_abnormal_cardiac_muscle	0.71183070
76	MP0003705_abnormal_hypodermis_morpholog	0.70775044
77	MP0004133_heterotaxia	0.69632631
78	MP0002452_abnormal_antigen_presenting	0.69198109
79	MP0002234_abnormal_pharynx_morphology	0.68760577
80	MP0000427_abnormal_hair_cycle	0.67605113
81	MP0009765_abnormal_xenobiotic_induced	0.67401807
82	MP0004957_abnormal_blastocyst_morpholog	0.66200588
83	MP0010155_abnormal_intestine_physiology	0.65684309
84	MP0005584_abnormal_enzyme/coenzyme_acti	0.63273945
85	MP0004215_abnormal_myocardial_fiber	0.63022128
86	MP0002723_abnormal_immune_serum	0.62645007
87	MP0001756_abnormal_urination	0.62543266
88	MP0005377_hearing/vestibular/ear_phenot	0.61739743
89	MP0003878_abnormal_ear_physiology	0.61739743
90	MP0002928_abnormal_bile_duct	0.59974562
91	MP0000538_abnormal_urinary_bladder	0.59072848
92	MP0003937_abnormal_limbs/digits/tail_de	0.57840703
93	MP0003936_abnormal_reproductive_system	0.55914667
94	MP0000703_abnormal_thymus_morphology	0.55214145
95	MP0002295_abnormal_pulmonary_circulatio	0.54869995
96	MP0002735_abnormal_chemical_nociception	0.54211565
97	MP0000613_abnormal_salivary_gland	0.53854510
98	MP0005165_increased_susceptibility_to	0.53778772
99	MP0009764_decreased_sensitivity_to	0.53567492
100	MP0004130_abnormal_muscle_cell	0.53275381

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	7.68884292
2	Hyperalaninemia (HP:0003348)	7.68884292
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	7.68884292
4	Homocystinuria (HP:0002156)	4.64414056
5	Abnormality of homocysteine metabolism (HP:0010919)	4.64414056
6	Constricted visual fields (HP:0001133)	4.52495669
7	Abnormality of serum amino acid levels (HP:0003112)	4.12583127
8	Esophageal varix (HP:0002040)	4.07784714
9	Congenital sensorineural hearing impairment (HP:0008527)	4.01482173
10	Methylmalonic acidemia (HP:0002912)	3.72469719
11	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.65974873
12	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.43472746
13	Spontaneous hematomas (HP:0007420)	3.34764018
14	Anorexia (HP:0002039)	3.25735112
15	Elevated erythrocyte sedimentation rate (HP:0003565)	3.17327239
16	Attenuation of retinal blood vessels (HP:0007843)	3.16666242
17	Pendular nystagmus (HP:0012043)	3.12404647
18	Birth length less than 3rd percentile (HP:0003561)	3.02626922
19	Hyperglycinemia (HP:0002154)	3.01015520
20	White forelock (HP:0002211)	2.96731277
21	Methylmalonic aciduria (HP:0012120)	2.74044892
22	Abnormality of methionine metabolism (HP:0010901)	2.73530840
23	Patchy hypopigmentation of hair (HP:0011365)	2.71601083
24	Type 2 muscle fiber atrophy (HP:0003554)	2.71146571
25	Conjugated hyperbilirubinemia (HP:0002908)	2.69950588
26	Pigmentary retinal degeneration (HP:0001146)	2.68126932
27	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.58605117
28	Pulmonary embolism (HP:0002204)	2.51555439
29	Abnormal umbilical cord blood vessels (HP:0011403)	2.49268912
30	Single umbilical artery (HP:0001195)	2.49268912
31	Abnormality of the fetal cardiovascular system (HP:0010948)	2.49268912
32	Heterochromia iridis (HP:0001100)	2.48877972
33	Abnormality of the carotid arteries (HP:0005344)	2.48351787
34	Abnormality of vitamin B metabolism (HP:0004340)	2.42870759
35	Oligomenorrhea (HP:0000876)	2.42443731
36	Generalized aminoaciduria (HP:0002909)	2.38560341
37	Abnormality of glycine metabolism (HP:0010895)	2.32201994
38	Abnormality of serine family amino acid metabolism (HP:0010894)	2.32201994
39	Increased serum pyruvate (HP:0003542)	2.30681944
40	Increased serum lactate (HP:0002151)	2.30629920
41	Megaloblastic anemia (HP:0001889)	2.30021357
42	Action tremor (HP:0002345)	2.28393454
43	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.28150409
44	Poor speech (HP:0002465)	2.27670259
45	Thyroiditis (HP:0100646)	2.26046652
46	Chorioretinal atrophy (HP:0000533)	2.25709573
47	Abolished electroretinogram (ERG) (HP:0000550)	2.24559861
48	Muscle fiber atrophy (HP:0100295)	2.22826561
49	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.19361722
50	Hypomagnesemia (HP:0002917)	2.18549444
51	3-Methylglutaconic aciduria (HP:0003535)	2.17745731
52	Conjunctival telangiectasia (HP:0000524)	2.12917833
53	Delayed CNS myelination (HP:0002188)	2.12371621
54	Tetraparesis (HP:0002273)	2.12345917
55	Meckel diverticulum (HP:0002245)	2.11283925
56	Arteriovenous malformation (HP:0100026)	2.08982658
57	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.07253617
58	Aplasia/hypoplasia of the uterus (HP:0008684)	2.05513533
59	Fatigue (HP:0012378)	2.05162279
60	Chronic otitis media (HP:0000389)	2.04534076
61	Arterial thrombosis (HP:0004420)	2.03608277
62	Abnormality of the ileum (HP:0001549)	2.02668152
63	Insulin-resistant diabetes mellitus (HP:0000831)	2.01780874
64	Hepatocellular necrosis (HP:0001404)	2.01462886
65	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.00188077
66	Portal hypertension (HP:0001409)	1.99750689
67	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.98805676
68	Thrombophlebitis (HP:0004418)	1.98516127
69	Increased corneal curvature (HP:0100692)	1.98151994
70	Keratoconus (HP:0000563)	1.98151994
71	Tubulointerstitial nephritis (HP:0001970)	1.97583799
72	Hypoplasia of the uterus (HP:0000013)	1.96918162
73	Maternal diabetes (HP:0009800)	1.96246493
74	Dyskinesia (HP:0100660)	1.96161820
75	Tubulointerstitial abnormality (HP:0001969)	1.95103706
76	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.92155703
77	Abnormal rod and cone electroretinograms (HP:0008323)	1.90208766
78	Pancreatic cysts (HP:0001737)	1.88457656
79	Opisthotonus (HP:0002179)	1.87225806
80	Fibular aplasia (HP:0002990)	1.86714108
81	True hermaphroditism (HP:0010459)	1.85984696
82	Congenital, generalized hypertrichosis (HP:0004540)	1.85698475
83	Lactic acidosis (HP:0003128)	1.85589471
84	Spastic paraparesis (HP:0002313)	1.84053407
85	Metabolic acidosis (HP:0001942)	1.82581879
86	Abnormal respiratory epithelium morphology (HP:0012253)	1.82379572
87	Abnormal respiratory motile cilium morphology (HP:0005938)	1.82379572
88	Bone marrow hypocellularity (HP:0005528)	1.80203332
89	Hepatic necrosis (HP:0002605)	1.78670799
90	Hypoalphalipoproteinemia (HP:0003233)	1.78192178
91	Abnormality of the hepatic vasculature (HP:0006707)	1.77999933
92	Myocardial infarction (HP:0001658)	1.77768832
93	Ketoacidosis (HP:0001993)	1.76217418
94	Neoplasm of the adrenal cortex (HP:0100641)	1.74494000
95	Hemoptysis (HP:0002105)	1.74364736
96	Tubulointerstitial fibrosis (HP:0005576)	1.73876567
97	Hyperglycemia (HP:0003074)	1.72730989
98	Abnormality of glycolysis (HP:0004366)	1.72057174
99	Lethargy (HP:0001254)	1.70476348
100	Abnormality of magnesium homeostasis (HP:0004921)	1.70302576

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.82212024
2	FRK	4.41303292
3	EIF2AK1	3.40837689
4	EIF2AK3	3.28178285
5	CCNB1	2.78455695
6	ZAK	2.72000095
7	VRK2	2.38974054
8	NUAK1	2.38325811
9	MKNK1	2.25676912
10	TAF1	2.25380581
11	TXK	2.21803757
12	TLK1	2.16696010
13	MAP3K3	2.14192256
14	MAP2K3	2.01113817
15	SRPK1	1.91538686
16	TSSK6	1.87054706
17	PLK3	1.85940403
18	FGFR2	1.77689861
19	MST4	1.75292398
20	NEK1	1.60939432
21	BCKDK	1.53635750
22	FGR	1.50988308
23	JAK3	1.34811904
24	CDK9	1.33608596
25	MKNK2	1.32785631
26	TIE1	1.25704326
27	RIPK4	1.22673974
28	ADRBK1	1.22097265
29	PBK	1.21725700
30	ACVR1B	1.20843560
31	MAP4K1	1.20172603
32	ADRBK2	1.20121603
33	NEK6	1.20079523
34	YES1	1.19473170
35	GRK1	1.18842138
36	VRK1	1.18433782
37	EIF2AK2	1.13146643
38	PLK2	1.07347997
39	NTRK2	1.05138912
40	RPS6KB2	1.03729513
41	PHKG1	1.03318457
42	PHKG2	1.03318457
43	PINK1	0.98601191
44	MAPKAPK5	0.98592981
45	FES	0.87024513
46	BUB1	0.82745094
47	TAOK3	0.82022227
48	CSNK1G1	0.73729004
49	ERBB3	0.73520445
50	CSNK1A1	0.73165595
51	PIK3CA	0.73030546
52	EPHB2	0.72756765
53	WNK3	0.68474670
54	PRKCQ	0.67222598
55	TNK2	0.65862625
56	GRK6	0.63807694
57	GRK5	0.62237856
58	CSNK1G3	0.61661459
59	PASK	0.61471498
60	ATR	0.60886782
61	PRKCI	0.60749915
62	PLK4	0.60288231
63	PLK1	0.57899908
64	SGK494	0.54318525
65	SGK223	0.54318525
66	STK10	0.54031392
67	CDK7	0.52045334
68	CSNK1A1L	0.50831737
69	INSRR	0.48478358
70	SYK	0.47611459
71	SGK2	0.46574390
72	BMPR1B	0.44092050
73	OXSR1	0.43719234
74	CSNK1G2	0.43110902
75	PAK6	0.42666984
76	TEC	0.42262017
77	NME2	0.42181855
78	TRIM28	0.40257655
79	ALK	0.40060291
80	FER	0.37707000
81	DYRK2	0.36919883
82	PRKCA	0.36344127
83	IKBKE	0.36313019
84	NTRK3	0.36185225
85	EPHA3	0.36038857
86	PRKCE	0.35945589
87	INSR	0.35231688
88	BRSK2	0.34579339
89	RPS6KA5	0.34408422
90	LYN	0.32422554
91	LCK	0.32327207
92	CSNK2A1	0.27962473
93	ATM	0.27951956
94	CAMKK2	0.27406614
95	CHEK2	0.27216902
96	DMPK	0.24732513
97	CAMK2D	0.24731379
98	TTK	0.24304116
99	PRKCD	0.23862303
100	AURKB	0.23325883

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	8.52675009
2	Proteasome_Homo sapiens_hsa03050	3.22854002
3	One carbon pool by folate_Homo sapiens_hsa00670	3.02387642
4	Sulfur metabolism_Homo sapiens_hsa00920	2.35504987
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.11113606
6	Linoleic acid metabolism_Homo sapiens_hsa00591	1.81037782
7	Selenocompound metabolism_Homo sapiens_hsa00450	1.78892869
8	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.73954317
9	RNA polymerase_Homo sapiens_hsa03020	1.72810703
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.61681748
11	Fanconi anemia pathway_Homo sapiens_hsa03460	1.60334065
12	Non-homologous end-joining_Homo sapiens_hsa03450	1.58647543
13	Oxidative phosphorylation_Homo sapiens_hsa00190	1.58049483
14	Propanoate metabolism_Homo sapiens_hsa00640	1.57543145
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.53656065
16	Asthma_Homo sapiens_hsa05310	1.52978214
17	RNA degradation_Homo sapiens_hsa03018	1.51307199
18	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.50801811
19	Collecting duct acid secretion_Homo sapiens_hsa04966	1.49295086
20	Allograft rejection_Homo sapiens_hsa05330	1.48773838
21	Homologous recombination_Homo sapiens_hsa03440	1.45594802
22	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.44472439
23	Basal transcription factors_Homo sapiens_hsa03022	1.39084377
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.37670000
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.36599911
26	Arginine biosynthesis_Homo sapiens_hsa00220	1.30303159
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.28273860
28	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.26039957
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.25311026
30	Phototransduction_Homo sapiens_hsa04744	1.24678101
31	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.22635510
32	Spliceosome_Homo sapiens_hsa03040	1.20794766
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.19792573
34	Graft-versus-host disease_Homo sapiens_hsa05332	1.19118714
35	Type I diabetes mellitus_Homo sapiens_hsa04940	1.17206405
36	Mismatch repair_Homo sapiens_hsa03430	1.09139577
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.06280931
38	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.05782976
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.04721419
40	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.04653895
41	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.03807909
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.03399915
43	RNA transport_Homo sapiens_hsa03013	0.99671619
44	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.95996601
45	Parkinsons disease_Homo sapiens_hsa05012	0.93563412
46	Olfactory transduction_Homo sapiens_hsa04740	0.90530511
47	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.88519050
48	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88353213
49	Sulfur relay system_Homo sapiens_hsa04122	0.87991259
50	Morphine addiction_Homo sapiens_hsa05032	0.84983987
51	Retinol metabolism_Homo sapiens_hsa00830	0.83856208
52	Protein export_Homo sapiens_hsa03060	0.81958139
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.79707995
54	Peroxisome_Homo sapiens_hsa04146	0.79344625
55	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.75241720
56	Purine metabolism_Homo sapiens_hsa00230	0.75100511
57	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.74573890
58	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.72864540
59	Nicotine addiction_Homo sapiens_hsa05033	0.70664548
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70394672
61	Serotonergic synapse_Homo sapiens_hsa04726	0.70390030
62	Base excision repair_Homo sapiens_hsa03410	0.68561383
63	Rheumatoid arthritis_Homo sapiens_hsa05323	0.67424924
64	GABAergic synapse_Homo sapiens_hsa04727	0.67018940
65	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.66954457
66	Pyrimidine metabolism_Homo sapiens_hsa00240	0.65957728
67	Metabolic pathways_Homo sapiens_hsa01100	0.64371113
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64038759
69	Antigen processing and presentation_Homo sapiens_hsa04612	0.63150442
70	Huntingtons disease_Homo sapiens_hsa05016	0.61034830
71	ABC transporters_Homo sapiens_hsa02010	0.57052867
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55859519
73	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.54606879
74	mRNA surveillance pathway_Homo sapiens_hsa03015	0.53901062
75	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.53601880
76	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.52529000
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50915021
78	Alzheimers disease_Homo sapiens_hsa05010	0.50794961
79	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.49080400
80	Regulation of autophagy_Homo sapiens_hsa04140	0.48472265
81	Butanoate metabolism_Homo sapiens_hsa00650	0.46044155
82	DNA replication_Homo sapiens_hsa03030	0.45151971
83	Taste transduction_Homo sapiens_hsa04742	0.42647431
84	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.42278235
85	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.41418313
86	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.40776801
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.40052029
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.37318333
89	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.36559177
90	Glutamatergic synapse_Homo sapiens_hsa04724	0.36203529
91	beta-Alanine metabolism_Homo sapiens_hsa00410	0.35666406
92	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.34785025
93	Primary immunodeficiency_Homo sapiens_hsa05340	0.34473806
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33135463
95	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.33034627
96	Nucleotide excision repair_Homo sapiens_hsa03420	0.29462271
97	Glutathione metabolism_Homo sapiens_hsa00480	0.28631966
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.28470941
99	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.26592028
100	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.26133555

HNRNPA1P19

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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