HNRNPA1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.53481500
2regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.43565055
3regulation of mitotic spindle checkpoint (GO:1903504)4.43565055
4proteasome assembly (GO:0043248)4.33789531
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.00789779
6positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.92903358
7establishment of protein localization to mitochondrial membrane (GO:0090151)3.74256708
8ATP synthesis coupled proton transport (GO:0015986)3.67120119
9energy coupled proton transport, down electrochemical gradient (GO:0015985)3.67120119
10kinetochore assembly (GO:0051382)3.64463179
11water-soluble vitamin biosynthetic process (GO:0042364)3.61899950
12protein neddylation (GO:0045116)3.54061919
13tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.49004582
14RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.49004582
15regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.47915252
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.45401857
17pseudouridine synthesis (GO:0001522)3.44535016
18chromatin remodeling at centromere (GO:0031055)3.41724768
19ribosomal small subunit assembly (GO:0000028)3.41048012
20regulation of immunoglobulin secretion (GO:0051023)3.38812750
21DNA replication-dependent nucleosome assembly (GO:0006335)3.30522588
22DNA replication-dependent nucleosome organization (GO:0034723)3.30522588
23rRNA modification (GO:0000154)3.28655583
24somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28116651
25somatic hypermutation of immunoglobulin genes (GO:0016446)3.28116651
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.27233206
27maturation of SSU-rRNA (GO:0030490)3.26946816
28CENP-A containing nucleosome assembly (GO:0034080)3.26817770
29DNA catabolic process, exonucleolytic (GO:0000738)3.25867070
30kinetochore organization (GO:0051383)3.21146105
31nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20113218
32exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19299088
33tRNA processing (GO:0008033)3.16726773
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.15640908
35NADH dehydrogenase complex assembly (GO:0010257)3.15640908
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15640908
37signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.15474409
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.15474409
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.15474409
40mitochondrial RNA metabolic process (GO:0000959)3.15087438
41piRNA metabolic process (GO:0034587)3.15086899
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.13884364
43termination of RNA polymerase III transcription (GO:0006386)3.13884364
44DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.13408826
45DNA double-strand break processing (GO:0000729)3.12252218
46histone exchange (GO:0043486)3.10701215
47RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.10406489
48DNA damage response, detection of DNA damage (GO:0042769)3.09733680
49regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.09235280
50DNA ligation (GO:0006266)3.07672553
51L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.05191906
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05012647
53intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05012647
54cullin deneddylation (GO:0010388)3.04495815
55protein complex biogenesis (GO:0070271)3.03277234
56somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.02337210
57somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.02337210
58isotype switching (GO:0045190)3.02337210
59maturation of 5.8S rRNA (GO:0000460)3.01529136
60signal transduction involved in DNA integrity checkpoint (GO:0072401)3.01262906
61signal transduction involved in DNA damage checkpoint (GO:0072422)3.01262906
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99468924
63signal transduction involved in cell cycle checkpoint (GO:0072395)2.99065700
64regulation of isotype switching to IgG isotypes (GO:0048302)2.96803161
65mitochondrial respiratory chain complex assembly (GO:0033108)2.95869101
66chaperone-mediated protein transport (GO:0072321)2.92570951
67negative regulation of DNA-dependent DNA replication (GO:2000104)2.92099839
68IMP biosynthetic process (GO:0006188)2.91774981
69regulation of cellular amino acid metabolic process (GO:0006521)2.91148994
70ribosome assembly (GO:0042255)2.90188290
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89929983
72negative regulation of ligase activity (GO:0051352)2.89929983
73tRNA metabolic process (GO:0006399)2.89777863
74synapsis (GO:0007129)2.88242741
75rRNA processing (GO:0006364)2.88223322
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87462041
77rRNA methylation (GO:0031167)2.86850814
78rRNA metabolic process (GO:0016072)2.84972992
79nucleobase biosynthetic process (GO:0046112)2.83606271
80protein deneddylation (GO:0000338)2.80382348
81mismatch repair (GO:0006298)2.78210931
82respiratory chain complex IV assembly (GO:0008535)2.78200972
83tRNA modification (GO:0006400)2.76806143
84ribosomal large subunit biogenesis (GO:0042273)2.75652856
85L-methionine salvage (GO:0071267)2.73970054
86L-methionine biosynthetic process (GO:0071265)2.73970054
87amino acid salvage (GO:0043102)2.73970054
88purine nucleobase biosynthetic process (GO:0009113)2.73246312
89male meiosis (GO:0007140)2.72902918
90adenosine metabolic process (GO:0046085)2.71361897
91ncRNA metabolic process (GO:0034660)2.70403547
92preassembly of GPI anchor in ER membrane (GO:0016254)2.68720726
93regulation of nuclear cell cycle DNA replication (GO:0033262)2.67707172
94organelle disassembly (GO:1903008)2.66673748
95ncRNA processing (GO:0034470)2.65376239
96transcription from mitochondrial promoter (GO:0006390)2.64947573
97regulation of chronic inflammatory response (GO:0002676)2.63402845
98somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.62756779
99somatic cell DNA recombination (GO:0016444)2.62756779
100somatic diversification of immune receptors (GO:0002200)2.62119043

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.10929916
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.25161345
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.63569541
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.22425771
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.16613115
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.07909873
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.05381957
8E2F7_22180533_ChIP-Seq_HELA_Human2.76569832
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.74197252
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59688562
11VDR_23849224_ChIP-Seq_CD4+_Human2.58054046
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57010907
13ELK1_19687146_ChIP-ChIP_HELA_Human2.54098654
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.53754865
15VDR_22108803_ChIP-Seq_LS180_Human2.45358223
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.44041273
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40620252
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36570896
19ZNF274_21170338_ChIP-Seq_K562_Hela2.28195560
20FOXP3_21729870_ChIP-Seq_TREG_Human2.22796237
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15816488
22EWS_26573619_Chip-Seq_HEK293_Human2.04041684
23MYC_18940864_ChIP-ChIP_HL60_Human1.98836125
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.95702385
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.95578915
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94716437
27FUS_26573619_Chip-Seq_HEK293_Human1.88860226
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88394317
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.82811100
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82665400
31IRF1_19129219_ChIP-ChIP_H3396_Human1.81146914
32IGF1R_20145208_ChIP-Seq_DFB_Human1.80244179
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75081993
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.71893947
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68057081
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.64845595
37TTF2_22483619_ChIP-Seq_HELA_Human1.63230584
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61416044
39TAF15_26573619_Chip-Seq_HEK293_Human1.56816701
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55414293
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47405772
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46276222
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46060437
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44085598
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43703217
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39504661
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37305173
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35033005
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.31791008
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28154999
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27927206
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26999864
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.26999864
54TP53_22573176_ChIP-Seq_HFKS_Human1.25525339
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25027595
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24061256
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.23742678
58P300_19829295_ChIP-Seq_ESCs_Human1.23645229
59DCP1A_22483619_ChIP-Seq_HELA_Human1.23637666
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21473614
61ER_23166858_ChIP-Seq_MCF-7_Human1.21323992
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18896332
63E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18202041
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16962479
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13581760
66XRN2_22483619_ChIP-Seq_HELA_Human1.13491565
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13135190
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13099772
69CBP_20019798_ChIP-Seq_JUKART_Human1.11501650
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11501650
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11433348
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10938736
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.07467634
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.06029377
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05211868
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05208042
77GABP_19822575_ChIP-Seq_HepG2_Human1.05062327
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04477896
79AR_20517297_ChIP-Seq_VCAP_Human1.03667857
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00576447
81E2F1_21310950_ChIP-Seq_MCF-7_Human0.98814867
82NCOR_22424771_ChIP-Seq_293T_Human0.97815467
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96165738
84CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95645223
85AR_21909140_ChIP-Seq_LNCAP_Human0.95351068
86ELK1_22589737_ChIP-Seq_MCF10A_Human0.95150349
87NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94030119
88KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93991843
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92734168
90NANOG_19829295_ChIP-Seq_ESCs_Human0.91882137
91SOX2_19829295_ChIP-Seq_ESCs_Human0.91882137
92NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91346707
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91321250
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.89973978
95EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89420348
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88987266
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87278517
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.86952461
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86418885
100SALL4_22934838_ChIP-ChIP_CD34+_Human0.85129642

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation3.82311685
2MP0006292_abnormal_olfactory_placode3.48865776
3MP0002102_abnormal_ear_morphology3.24025731
4MP0008877_abnormal_DNA_methylation3.05171714
5MP0003718_maternal_effect2.62453765
6MP0003806_abnormal_nucleotide_metabolis2.61257575
7MP0008058_abnormal_DNA_repair2.58168490
8MP0006072_abnormal_retinal_apoptosis2.54226682
9MP0001293_anophthalmia2.49076235
10MP0000566_synostosis2.47012634
11MP0010094_abnormal_chromosome_stability2.39964154
12MP0003693_abnormal_embryo_hatching2.35556906
13MP0005377_hearing/vestibular/ear_phenot2.32427720
14MP0003878_abnormal_ear_physiology2.32427720
15MP0005075_abnormal_melanosome_morpholog2.16678892
16MP0002938_white_spotting2.07932733
17MP0005408_hypopigmentation1.95994174
18MP0003567_abnormal_fetal_cardiomyocyte1.88482160
19MP0003786_premature_aging1.86709065
20MP0004957_abnormal_blastocyst_morpholog1.83687262
21MP0005084_abnormal_gallbladder_morpholo1.73340135
22MP0001348_abnormal_lacrimal_gland1.72540958
23MP0005253_abnormal_eye_physiology1.71587411
24MP0003111_abnormal_nucleus_morphology1.65529799
25MP0008872_abnormal_physiological_respon1.64135990
26MP0002736_abnormal_nociception_after1.63652561
27MP0005671_abnormal_response_to1.62488323
28MP0008875_abnormal_xenobiotic_pharmacok1.54721864
29MP0004147_increased_porphyrin_level1.51711457
30MP0004885_abnormal_endolymph1.39670437
31MP0001968_abnormal_touch/_nociception1.36420327
32MP0002234_abnormal_pharynx_morphology1.36183799
33MP0001529_abnormal_vocalization1.36165474
34MP0001835_abnormal_antigen_presentation1.33009709
35MP0005551_abnormal_eye_electrophysiolog1.32884805
36MP0003195_calcinosis1.31717936
37MP0003136_yellow_coat_color1.31228356
38MP0000537_abnormal_urethra_morphology1.26385924
39MP0008007_abnormal_cellular_replicative1.20645583
40MP0002095_abnormal_skin_pigmentation1.19148327
41MP0008995_early_reproductive_senescence1.18126794
42MP0000631_abnormal_neuroendocrine_gland1.16199036
43MP0006036_abnormal_mitochondrial_physio1.16143805
44MP0002837_dystrophic_cardiac_calcinosis1.14416196
45MP0000647_abnormal_sebaceous_gland1.11772009
46MP0003077_abnormal_cell_cycle1.10771969
47MP0003186_abnormal_redox_activity1.09939172
48MP0001485_abnormal_pinna_reflex1.08721834
49MP0001984_abnormal_olfaction1.07162191
50MP0005646_abnormal_pituitary_gland1.06893861
51MP0003121_genomic_imprinting1.06481112
52MP0001764_abnormal_homeostasis1.03113292
53MP0002282_abnormal_trachea_morphology1.02890139
54MP0002751_abnormal_autonomic_nervous1.02345640
55MP0001929_abnormal_gametogenesis1.01925383
56MP0003646_muscle_fatigue0.98533855
57MP0008789_abnormal_olfactory_epithelium0.97403486
58MP0005391_vision/eye_phenotype0.97361003
59MP0002210_abnormal_sex_determination0.97324294
60MP0001853_heart_inflammation0.96472366
61MP0000569_abnormal_digit_pigmentation0.95946931
62MP0003011_delayed_dark_adaptation0.95593479
63MP0002272_abnormal_nervous_system0.95532624
64MP0002006_tumorigenesis0.94497021
65MP0003937_abnormal_limbs/digits/tail_de0.94363144
66MP0002138_abnormal_hepatobiliary_system0.94036124
67MP0008932_abnormal_embryonic_tissue0.93438892
68MP0009046_muscle_twitch0.89681174
69MP0003787_abnormal_imprinting0.88373033
70MP0004043_abnormal_pH_regulation0.86982690
71MP0006035_abnormal_mitochondrial_morpho0.84222869
72MP0000049_abnormal_middle_ear0.83313169
73MP0004142_abnormal_muscle_tone0.83233598
74MP0001119_abnormal_female_reproductive0.82601382
75MP0001145_abnormal_male_reproductive0.82080858
76MP0000653_abnormal_sex_gland0.81683413
77MP0001986_abnormal_taste_sensitivity0.81055158
78MP0005174_abnormal_tail_pigmentation0.79655104
79MP0003119_abnormal_digestive_system0.79353486
80MP0005389_reproductive_system_phenotype0.78969307
81MP0008775_abnormal_heart_ventricle0.77257687
82MP0009697_abnormal_copulation0.76733361
83MP0001919_abnormal_reproductive_system0.74078659
84MP0004133_heterotaxia0.73701719
85MP0001324_abnormal_eye_pigmentation0.72196615
86MP0005167_abnormal_blood-brain_barrier0.70758891
87MP0010030_abnormal_orbit_morphology0.70617678
88MP0003880_abnormal_central_pattern0.69777748
89MP0001286_abnormal_eye_development0.68592324
90MP0000427_abnormal_hair_cycle0.68378995
91MP0003698_abnormal_male_reproductive0.68364605
92MP0005645_abnormal_hypothalamus_physiol0.67706135
93MP0002111_abnormal_tail_morphology0.67207688
94MP0000490_abnormal_crypts_of0.67119921
95MP0003283_abnormal_digestive_organ0.66834415
96MP0004924_abnormal_behavior0.65691627
97MP0005386_behavior/neurological_phenoty0.65691627
98MP0004134_abnormal_chest_morphology0.65350658
99MP0002822_catalepsy0.64715639
100MP0001873_stomach_inflammation0.62946839

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.70330326
2Acute necrotizing encephalopathy (HP:0006965)3.54700509
3Colon cancer (HP:0003003)3.44095950
4Acute encephalopathy (HP:0006846)3.30679383
5Increased hepatocellular lipid droplets (HP:0006565)3.27850537
6Increased CSF lactate (HP:0002490)3.23834956
7Mitochondrial inheritance (HP:0001427)3.19782357
8Lipid accumulation in hepatocytes (HP:0006561)3.17584940
9Progressive macrocephaly (HP:0004481)3.08628032
10Methylmalonic acidemia (HP:0002912)3.00957155
11Abnormality of aspartate family amino acid metabolism (HP:0010899)2.96196433
12Abnormal mitochondria in muscle tissue (HP:0008316)2.90740013
13Pancreatic cysts (HP:0001737)2.84139733
14Congenital stationary night blindness (HP:0007642)2.81445232
15IgG deficiency (HP:0004315)2.78478114
16Aplasia/Hypoplasia of the uvula (HP:0010293)2.61004356
17Abnormality of serum amino acid levels (HP:0003112)2.59916100
18Renal cortical cysts (HP:0000803)2.57545784
19Hyperglycinemia (HP:0002154)2.53088022
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.51729621
21Abnormality of alanine metabolism (HP:0010916)2.51729621
22Hyperalaninemia (HP:0003348)2.51729621
23Increased serum lactate (HP:0002151)2.51441953
24Renal Fanconi syndrome (HP:0001994)2.50356525
25Abnormality of methionine metabolism (HP:0010901)2.47643197
26Cerebral edema (HP:0002181)2.46730379
27Decreased central vision (HP:0007663)2.46237569
28True hermaphroditism (HP:0010459)2.45984858
29Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45658431
30Pancreatic fibrosis (HP:0100732)2.45297098
31Abnormality of the pons (HP:0007361)2.42580971
32Hepatocellular necrosis (HP:0001404)2.40037543
33Bilateral microphthalmos (HP:0007633)2.38882710
34Abnormality of midbrain morphology (HP:0002418)2.35239734
35Molar tooth sign on MRI (HP:0002419)2.35239734
36Abnormality of the ileum (HP:0001549)2.34272820
37Meckel diverticulum (HP:0002245)2.32534837
38Aplasia/hypoplasia of the uterus (HP:0008684)2.31919568
39Ependymoma (HP:0002888)2.30047035
40Methylmalonic aciduria (HP:0012120)2.28593986
41Hypoplasia of the uterus (HP:0000013)2.27798889
42Nephronophthisis (HP:0000090)2.26869227
43Pendular nystagmus (HP:0012043)2.26404918
44Hepatic necrosis (HP:0002605)2.24479949
45Optic disc pallor (HP:0000543)2.20906400
46Hypoplasia of the fovea (HP:0007750)2.20798791
47Aplasia/Hypoplasia of the fovea (HP:0008060)2.20798791
48Abnormal lung lobation (HP:0002101)2.20261779
49Abolished electroretinogram (ERG) (HP:0000550)2.19718042
50Pancytopenia (HP:0001876)2.17204856
51Type 2 muscle fiber atrophy (HP:0003554)2.14476760
52Stomach cancer (HP:0012126)2.13777424
53Exertional dyspnea (HP:0002875)2.12216474
54Pancreatic islet-cell hyperplasia (HP:0004510)2.11533355
55Abnormality of the preputium (HP:0100587)2.10902110
56Hypoplasia of the pons (HP:0012110)2.10030741
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.09547285
58Intestinal atresia (HP:0011100)2.07230687
593-Methylglutaconic aciduria (HP:0003535)2.06471673
60Lactic acidosis (HP:0003128)2.04739105
61Abnormality of the vitamin B12 metabolism (HP:0004341)2.03261516
62Absent thumb (HP:0009777)2.02068871
63Abnormality of the renal cortex (HP:0011035)1.99676295
64Abnormality of glycine metabolism (HP:0010895)1.96947733
65Abnormality of serine family amino acid metabolism (HP:0010894)1.96947733
66Abnormal rod and cone electroretinograms (HP:0008323)1.96844792
67Leukodystrophy (HP:0002415)1.95734366
68Cleft eyelid (HP:0000625)1.94493038
69Congenital, generalized hypertrichosis (HP:0004540)1.94436583
70Type II lissencephaly (HP:0007260)1.93640552
71Inability to walk (HP:0002540)1.90724464
72Small intestinal stenosis (HP:0012848)1.89951171
73Duodenal stenosis (HP:0100867)1.89951171
74Septo-optic dysplasia (HP:0100842)1.89847841
75Sclerocornea (HP:0000647)1.86128161
76Abnormality of vitamin B metabolism (HP:0004340)1.84964447
77Hyperglycinuria (HP:0003108)1.84278995
78Abnormality of the fovea (HP:0000493)1.83238367
79Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82998481
80Lethargy (HP:0001254)1.82261656
81Agnosia (HP:0010524)1.80125385
82Type I transferrin isoform profile (HP:0003642)1.78618588
83Neoplasm of the adrenal cortex (HP:0100641)1.78380489
84Horseshoe kidney (HP:0000085)1.76365715
85Anophthalmia (HP:0000528)1.76307156
86Abnormal number of erythroid precursors (HP:0012131)1.76134512
87Abnormality of the duodenum (HP:0002246)1.74524670
88Triphalangeal thumb (HP:0001199)1.74437193
89Abnormality of the renal medulla (HP:0100957)1.73775699
90Muscle fiber atrophy (HP:0100295)1.72793477
91Glycosuria (HP:0003076)1.72720988
92Abnormality of urine glucose concentration (HP:0011016)1.72720988
93Gonadotropin excess (HP:0000837)1.72283748
94Constricted visual fields (HP:0001133)1.72216895
95Glioma (HP:0009733)1.71711230
96Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71256619
97Medial flaring of the eyebrow (HP:0010747)1.70541030
98Abnormality of the prostate (HP:0008775)1.70152690
99Sensory axonal neuropathy (HP:0003390)1.68843465
100Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.68179129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.50806288
2BUB13.16498814
3VRK23.10533063
4PBK3.03163258
5TLK12.81496818
6NUAK12.53904636
7TSSK62.41492588
8PLK32.40391123
9VRK12.31653700
10PLK42.30232737
11WEE12.17924397
12TXK2.13931799
13FRK2.13771988
14EIF2AK32.12641864
15NEK12.08569020
16MKNK12.02714458
17BRSK21.91107562
18SRPK11.89738190
19WNK31.87025625
20MST41.83783779
21MKNK21.79515676
22TAF11.79010140
23MAP4K21.78295858
24ADRBK21.53711907
25PDK21.51930171
26EIF2AK11.47988785
27BMPR1B1.42236807
28STK161.41698692
29TRIM281.37022970
30NME11.33790018
31EIF2AK21.32891752
32GRK11.31212534
33ERBB31.25837539
34PLK21.21270161
35PASK1.16331954
36TTK1.14233801
37CDC71.14007008
38PINK11.13461415
39TAOK31.05899821
40PLK11.01249328
41TNIK1.00147719
42WNK40.97169544
43ATR0.95729835
44TEC0.92778824
45AURKB0.87426952
46DYRK20.84172971
47CHEK20.80580649
48NEK20.78248773
49GRK60.77228252
50ITK0.75941681
51CSNK1G10.75418969
52TGFBR10.73128021
53FGFR20.67782477
54ALK0.64825185
55CSNK1G30.64244740
56STK390.63075162
57OXSR10.62606870
58GRK50.61167671
59BRSK10.60298481
60STK40.60271605
61BCKDK0.59561529
62EPHB20.57370541
63TIE10.56943221
64CDK30.56768219
65WNK10.54099812
66PIK3CG0.53503008
67PRKCG0.52779575
68CSNK1A1L0.49602878
69DAPK10.48562043
70INSRR0.47944378
71IKBKB0.47555296
72TESK20.47140328
73ERBB20.46639757
74ATM0.46549746
75ACVR1B0.46055402
76RPS6KA50.45216536
77MAP3K40.42023905
78CSNK1G20.41635331
79CSNK2A10.40472603
80CSNK2A20.38960358
81SYK0.38128166
82IGF1R0.35361369
83PIM10.34031684
84CHEK10.33386703
85STK38L0.32126160
86CSNK1E0.31678580
87CSNK1A10.31645173
88CDK70.31185327
89MARK30.31017420
90MAP4K10.28733746
91FGFR10.27788186
92MAPKAPK50.25783740
93PRKCA0.24755929
94PKN10.24184615
95PTK2B0.24073198
96LYN0.23990370
97PHKG10.23923336
98PHKG20.23923336
99ADRBK10.23541558
100PRKCQ0.22819451

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.73761716
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.94740769
3Ribosome_Homo sapiens_hsa030102.70004067
4Protein export_Homo sapiens_hsa030602.66323586
5RNA polymerase_Homo sapiens_hsa030202.64629910
6One carbon pool by folate_Homo sapiens_hsa006702.51778551
7Mismatch repair_Homo sapiens_hsa034302.48021069
8Oxidative phosphorylation_Homo sapiens_hsa001902.37413716
9DNA replication_Homo sapiens_hsa030302.33994073
10Asthma_Homo sapiens_hsa053102.33724739
11Homologous recombination_Homo sapiens_hsa034402.31327041
12RNA degradation_Homo sapiens_hsa030182.08192773
13Fanconi anemia pathway_Homo sapiens_hsa034602.07465113
14Parkinsons disease_Homo sapiens_hsa050122.06103577
15Non-homologous end-joining_Homo sapiens_hsa034501.97956096
16Base excision repair_Homo sapiens_hsa034101.96613641
17Basal transcription factors_Homo sapiens_hsa030221.96108553
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.94340823
19Allograft rejection_Homo sapiens_hsa053301.90498781
20Spliceosome_Homo sapiens_hsa030401.88690460
21Propanoate metabolism_Homo sapiens_hsa006401.88106649
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82227456
23Autoimmune thyroid disease_Homo sapiens_hsa053201.81250114
24RNA transport_Homo sapiens_hsa030131.75578531
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74128388
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56941895
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54551281
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.54212601
29Pyrimidine metabolism_Homo sapiens_hsa002401.47576109
30Nucleotide excision repair_Homo sapiens_hsa034201.36994197
31Huntingtons disease_Homo sapiens_hsa050161.36540293
32Tryptophan metabolism_Homo sapiens_hsa003801.27959805
33Purine metabolism_Homo sapiens_hsa002301.27410872
34Phototransduction_Homo sapiens_hsa047441.23353836
35Systemic lupus erythematosus_Homo sapiens_hsa053221.20642999
36Primary immunodeficiency_Homo sapiens_hsa053401.19497089
37Nitrogen metabolism_Homo sapiens_hsa009101.19010256
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18757462
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14080774
40Type I diabetes mellitus_Homo sapiens_hsa049401.13224707
41Linoleic acid metabolism_Homo sapiens_hsa005911.12752554
42Graft-versus-host disease_Homo sapiens_hsa053321.11347559
43Alzheimers disease_Homo sapiens_hsa050101.09398954
44Butanoate metabolism_Homo sapiens_hsa006500.99426426
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97758204
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95592042
47Cell cycle_Homo sapiens_hsa041100.94130832
48Caffeine metabolism_Homo sapiens_hsa002320.90534104
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87546149
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87345979
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85002154
52Pyruvate metabolism_Homo sapiens_hsa006200.84852669
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82627426
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78462248
55Selenocompound metabolism_Homo sapiens_hsa004500.73052093
56Vitamin digestion and absorption_Homo sapiens_hsa049770.70992137
57Peroxisome_Homo sapiens_hsa041460.69643128
58p53 signaling pathway_Homo sapiens_hsa041150.68557447
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.68107221
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67734904
61Glutathione metabolism_Homo sapiens_hsa004800.66539990
62Antigen processing and presentation_Homo sapiens_hsa046120.65722004
63Metabolic pathways_Homo sapiens_hsa011000.63965659
64Olfactory transduction_Homo sapiens_hsa047400.63441068
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63228940
66Fat digestion and absorption_Homo sapiens_hsa049750.63107220
67Hematopoietic cell lineage_Homo sapiens_hsa046400.57628638
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57322469
69Cardiac muscle contraction_Homo sapiens_hsa042600.56688278
70Chemical carcinogenesis_Homo sapiens_hsa052040.56462115
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54298396
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53548993
73Nicotine addiction_Homo sapiens_hsa050330.51944052
74mRNA surveillance pathway_Homo sapiens_hsa030150.51914521
75Carbon metabolism_Homo sapiens_hsa012000.50913280
76Fatty acid degradation_Homo sapiens_hsa000710.50516087
77Arachidonic acid metabolism_Homo sapiens_hsa005900.49863226
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49412587
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48367381
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47487309
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45094145
82Fatty acid elongation_Homo sapiens_hsa000620.44784396
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44493922
84Retinol metabolism_Homo sapiens_hsa008300.44042904
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42625520
86Alcoholism_Homo sapiens_hsa050340.41526096
87Steroid biosynthesis_Homo sapiens_hsa001000.41514206
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40693563
89Ether lipid metabolism_Homo sapiens_hsa005650.40578245
90Epstein-Barr virus infection_Homo sapiens_hsa051690.40117275
91Oocyte meiosis_Homo sapiens_hsa041140.40068588
92beta-Alanine metabolism_Homo sapiens_hsa004100.37691431
93Taste transduction_Homo sapiens_hsa047420.37078437
94Regulation of autophagy_Homo sapiens_hsa041400.37018771
95Biosynthesis of amino acids_Homo sapiens_hsa012300.36408844
96Sulfur relay system_Homo sapiens_hsa041220.35902068
97Arginine and proline metabolism_Homo sapiens_hsa003300.33564540
98Rheumatoid arthritis_Homo sapiens_hsa053230.33484853
99Tyrosine metabolism_Homo sapiens_hsa003500.32986553
100Vitamin B6 metabolism_Homo sapiens_hsa007500.32473513

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