ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	opioid receptor signaling pathway (GO:0038003)	5.15924666
2	proteasome assembly (GO:0043248)	4.81987877
3	DNA damage response, detection of DNA damage (GO:0042769)	4.59035083
4	chaperone-mediated protein transport (GO:0072321)	4.50769186
5	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.37501444
6	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.21891955
7	termination of RNA polymerase III transcription (GO:0006386)	4.21891955
8	base-excision repair, AP site formation (GO:0006285)	4.15074714
9	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.07159233
10	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.07159233
11	behavioral response to nicotine (GO:0035095)	4.06323108
12	maturation of 5.8S rRNA (GO:0000460)	4.02718913
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.85778534
14	ATP synthesis coupled proton transport (GO:0015986)	3.85778534
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.77845223
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.77845223
17	NADH dehydrogenase complex assembly (GO:0010257)	3.77845223
18	cellular ketone body metabolic process (GO:0046950)	3.76319661
19	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.74262666
20	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.70967882
21	protein neddylation (GO:0045116)	3.65256195
22	somite rostral/caudal axis specification (GO:0032525)	3.58991649
23	DNA deamination (GO:0045006)	3.50610530
24	L-fucose catabolic process (GO:0042355)	3.48901793
25	fucose catabolic process (GO:0019317)	3.48901793
26	L-fucose metabolic process (GO:0042354)	3.48901793
27	kynurenine metabolic process (GO:0070189)	3.47924897
28	protein complex biogenesis (GO:0070271)	3.46543084
29	pseudouridine synthesis (GO:0001522)	3.45582873
30	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.45252757
31	purine deoxyribonucleotide catabolic process (GO:0009155)	3.42024433
32	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.41160295
33	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.39898830
34	regulation of mitotic spindle checkpoint (GO:1903504)	3.39898830
35	maturation of SSU-rRNA (GO:0030490)	3.37854091
36	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.37363885
37	ketone body metabolic process (GO:1902224)	3.31379144
38	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.30214938
39	gamma-aminobutyric acid transport (GO:0015812)	3.18184054
40	rRNA catabolic process (GO:0016075)	3.15986533
41	tryptophan catabolic process (GO:0006569)	3.14973363
42	indole-containing compound catabolic process (GO:0042436)	3.14973363
43	indolalkylamine catabolic process (GO:0046218)	3.14973363
44	mitochondrial respiratory chain complex assembly (GO:0033108)	3.14286114
45	intracellular protein transmembrane import (GO:0044743)	3.13730612
46	water-soluble vitamin biosynthetic process (GO:0042364)	3.08477408
47	tRNA processing (GO:0008033)	3.08244371
48	endoderm formation (GO:0001706)	3.03712050
49	regulation of meiosis I (GO:0060631)	3.03538488
50	spliceosomal snRNP assembly (GO:0000387)	3.01834169
51	deoxyribonucleotide catabolic process (GO:0009264)	2.97364504
52	AMP metabolic process (GO:0046033)	2.95806215
53	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.94318403
54	deoxyribose phosphate catabolic process (GO:0046386)	2.92636822
55	C4-dicarboxylate transport (GO:0015740)	2.88460638
56	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.85786214
57	positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)	2.84867612
58	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.81986316
59	ribosomal small subunit assembly (GO:0000028)	2.81916464
60	tryptophan metabolic process (GO:0006568)	2.79720749
61	RNA phosphodiester bond hydrolysis (GO:0090501)	2.79560712
62	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.79450804
63	electron transport chain (GO:0022900)	2.79358967
64	tRNA metabolic process (GO:0006399)	2.78688973
65	response to pheromone (GO:0019236)	2.76283353
66	respiratory electron transport chain (GO:0022904)	2.76146640
67	preassembly of GPI anchor in ER membrane (GO:0016254)	2.76041092
68	tRNA modification (GO:0006400)	2.74911317
69	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.74567107
70	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.74567107
71	isotype switching (GO:0045190)	2.74567107
72	indolalkylamine metabolic process (GO:0006586)	2.72785415
73	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.72642648
74	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.69202139
75	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.69202139
76	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.69202139
77	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.68597665
78	signal peptide processing (GO:0006465)	2.66611073
79	regulation of cellular amino acid metabolic process (GO:0006521)	2.66122191
80	rRNA metabolic process (GO:0016072)	2.66011223
81	rRNA modification (GO:0000154)	2.65212382
82	positive regulation of protein homodimerization activity (GO:0090073)	2.64695260
83	transcription from RNA polymerase III promoter (GO:0006383)	2.64098008
84	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.62296379
85	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.62296379
86	rRNA processing (GO:0006364)	2.61335336
87	cullin deneddylation (GO:0010388)	2.61159254
88	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.61043867
89	protein deneddylation (GO:0000338)	2.60121611
90	indole-containing compound metabolic process (GO:0042430)	2.59563864
91	negative regulation of mast cell activation (GO:0033004)	2.59433447
92	purine deoxyribonucleotide metabolic process (GO:0009151)	2.58791208
93	protein-cofactor linkage (GO:0018065)	2.57682415
94	neuronal action potential (GO:0019228)	2.57554739
95	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.57000367
96	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.57000367
97	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.56562842
98	primary amino compound metabolic process (GO:1901160)	2.56436960
99	cellular component biogenesis (GO:0044085)	2.56078698
100	spliceosomal complex assembly (GO:0000245)	2.56027563

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.48592334
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.33574625
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.55906152
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.51982265
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.47791590
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.38655224
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.97175658
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.81901431
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.75279053
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.54392176
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.54057133
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.49300799
13	VDR_22108803_ChIP-Seq_LS180_Human	2.39558927
14	EWS_26573619_Chip-Seq_HEK293_Human	2.26437336
15	MYC_18940864_ChIP-ChIP_HL60_Human	2.20372069
16	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.17855661
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.16697720
18	FUS_26573619_Chip-Seq_HEK293_Human	2.12206071
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.90847327
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.89715709
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.88550115
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.87307048
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.82878625
24	GBX2_23144817_ChIP-Seq_PC3_Human	1.80879556
25	ELK1_19687146_ChIP-ChIP_HELA_Human	1.79962853
26	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.77123283
27	IGF1R_20145208_ChIP-Seq_DFB_Human	1.76537170
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.72586283
29	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.65913976
30	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.65614140
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64765918
32	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.63225918
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.63088099
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.63051114
35	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.48310551
36	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.46088557
37	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.45804849
38	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.44801671
39	P300_19829295_ChIP-Seq_ESCs_Human	1.41873859
40	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.38667501
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.38655707
42	GABP_19822575_ChIP-Seq_HepG2_Human	1.35307088
43	TAF15_26573619_Chip-Seq_HEK293_Human	1.30225251
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29671730
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29671730
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28646735
47	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.27719735
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.27701340
49	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.24641034
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20923077
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.20923077
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20890941
53	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.20380051
54	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.19029685
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.18977368
56	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.18433524
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18363552
58	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.17136565
59	AR_20517297_ChIP-Seq_VCAP_Human	1.15575667
60	TTF2_22483619_ChIP-Seq_HELA_Human	1.14578435
61	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.14345796
62	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13352890
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13164310
64	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.12407724
65	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.12284007
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10589134
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10200537
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10200537
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09744561
70	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.08632990
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06905781
72	NCOR_22424771_ChIP-Seq_293T_Human	1.06730095
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03786666
74	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.02945739
75	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.00220541
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.99872184
77	GATA3_26560356_Chip-Seq_TH2_Human	0.99845220
78	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.99574678
79	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99559933
80	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.99166847
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.97364620
82	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.95953866
83	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.95712147
84	AR_21572438_ChIP-Seq_LNCaP_Human	0.95673837
85	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.95336169
86	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.93881627
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.92609542
88	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92411146
89	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.90973502
90	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.90824677
91	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.90426235
92	XRN2_22483619_ChIP-Seq_HELA_Human	0.89923137
93	DCP1A_22483619_ChIP-Seq_HELA_Human	0.89768032
94	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.88875364
95	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.88376766
96	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.88005691
97	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.87657130
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.86798947
99	TCF4_23295773_ChIP-Seq_U87_Human	0.85892467
100	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.85684253

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	3.45033000
2	MP0006072_abnormal_retinal_apoptosis	3.28309022
3	MP0008995_early_reproductive_senescence	3.18815821
4	MP0006292_abnormal_olfactory_placode	3.12037488
5	MP0003195_calcinosis	3.11210316
6	MP0008877_abnormal_DNA_methylation	2.99229468
7	MP0003786_premature_aging	2.40377126
8	MP0005646_abnormal_pituitary_gland	2.32380170
9	MP0002163_abnormal_gland_morphology	2.19639064
10	MP0002876_abnormal_thyroid_physiology	2.14631236
11	MP0005551_abnormal_eye_electrophysiolog	2.07484967
12	MP0000372_irregular_coat_pigmentation	2.05559554
13	MP0008058_abnormal_DNA_repair	2.04835628
14	MP0003787_abnormal_imprinting	2.01219819
15	MP0003806_abnormal_nucleotide_metabolis	2.00721922
16	MP0005377_hearing/vestibular/ear_phenot	1.94772492
17	MP0003878_abnormal_ear_physiology	1.94772492
18	MP0008872_abnormal_physiological_respon	1.91805565
19	MP0003718_maternal_effect	1.90903210
20	MP0003693_abnormal_embryo_hatching	1.87002375
21	MP0005084_abnormal_gallbladder_morpholo	1.83862042
22	MP0005671_abnormal_response_to	1.83446972
23	MP0002102_abnormal_ear_morphology	1.72067737
24	MP0008875_abnormal_xenobiotic_pharmacok	1.69013689
25	MP0001529_abnormal_vocalization	1.65964267
26	MP0004147_increased_porphyrin_level	1.64359543
27	MP0002822_catalepsy	1.62771420
28	MP0003880_abnormal_central_pattern	1.62376991
29	MP0002277_abnormal_respiratory_mucosa	1.56405611
30	MP0005360_urolithiasis	1.55286302
31	MP0005253_abnormal_eye_physiology	1.51381252
32	MP0005379_endocrine/exocrine_gland_phen	1.44983526
33	MP0005332_abnormal_amino_acid	1.44888570
34	MP0001293_anophthalmia	1.43657719
35	MP0001502_abnormal_circadian_rhythm	1.42527576
36	MP0000569_abnormal_digit_pigmentation	1.42424065
37	MP0009745_abnormal_behavioral_response	1.41853629
38	MP0002272_abnormal_nervous_system	1.40894383
39	MP0003119_abnormal_digestive_system	1.33462857
40	MP0001984_abnormal_olfaction	1.27991924
41	MP0004145_abnormal_muscle_electrophysio	1.24950669
42	MP0008057_abnormal_DNA_replication	1.24023093
43	MP0001764_abnormal_homeostasis	1.22859242
44	MP0008961_abnormal_basal_metabolism	1.19306315
45	MP0003890_abnormal_embryonic-extraembry	1.19043681
46	MP0001968_abnormal_touch/_nociception	1.16906653
47	MP0003567_abnormal_fetal_cardiomyocyte	1.16241722
48	MP0008789_abnormal_olfactory_epithelium	1.14601479
49	MP0004142_abnormal_muscle_tone	1.14221709
50	MP0002938_white_spotting	1.13213926
51	MP0001501_abnormal_sleep_pattern	1.13049185
52	MP0000631_abnormal_neuroendocrine_gland	1.12790149
53	MP0002837_dystrophic_cardiac_calcinosis	1.08051109
54	MP0003011_delayed_dark_adaptation	1.07602741
55	MP0001485_abnormal_pinna_reflex	1.07102629
56	MP0005085_abnormal_gallbladder_physiolo	1.06976388
57	MP0006276_abnormal_autonomic_nervous	1.05685136
58	MP0000049_abnormal_middle_ear	1.02458947
59	MP0004885_abnormal_endolymph	1.02306439
60	MP0004215_abnormal_myocardial_fiber	1.02061236
61	MP0002736_abnormal_nociception_after	0.99988957
62	MP0001905_abnormal_dopamine_level	0.98333545
63	MP0009697_abnormal_copulation	0.98237366
64	MP0004043_abnormal_pH_regulation	0.96773740
65	MP0005410_abnormal_fertilization	0.93594116
66	MP0003121_genomic_imprinting	0.93300308
67	MP0005645_abnormal_hypothalamus_physiol	0.92881596
68	MP0001800_abnormal_humoral_immune	0.91790894
69	MP0009046_muscle_twitch	0.91484171
70	MP0002234_abnormal_pharynx_morphology	0.90464233
71	MP0005448_abnormal_energy_balance	0.89784734
72	MP0002735_abnormal_chemical_nociception	0.89255937
73	MP0001440_abnormal_grooming_behavior	0.87515262
74	MP0000647_abnormal_sebaceous_gland	0.87094733
75	MP0004957_abnormal_blastocyst_morpholog	0.87074715
76	MP0000465_gastrointestinal_hemorrhage	0.86046023
77	MP0002638_abnormal_pupillary_reflex	0.83347302
78	MP0008775_abnormal_heart_ventricle	0.82731087
79	MP0002751_abnormal_autonomic_nervous	0.81984888
80	MP0002210_abnormal_sex_determination	0.81813711
81	MP0004133_heterotaxia	0.81639797
82	MP0005394_taste/olfaction_phenotype	0.79832081
83	MP0005499_abnormal_olfactory_system	0.79832081
84	MP0001986_abnormal_taste_sensitivity	0.77017948
85	MP0002069_abnormal_eating/drinking_beha	0.76966190
86	MP0006036_abnormal_mitochondrial_physio	0.76390354
87	MP0003186_abnormal_redox_activity	0.76311048
88	MP0003646_muscle_fatigue	0.75775332
89	MP0001486_abnormal_startle_reflex	0.75221439
90	MP0005195_abnormal_posterior_eye	0.74171506
91	MP0002064_seizures	0.73019483
92	MP0010094_abnormal_chromosome_stability	0.72677475
93	MP0003936_abnormal_reproductive_system	0.72371426
94	MP0002148_abnormal_hypersensitivity_rea	0.71244437
95	MP0003724_increased_susceptibility_to	0.70819777
96	MP0005266_abnormal_metabolism	0.70563381
97	MP0002572_abnormal_emotion/affect_behav	0.69982161
98	MP0000653_abnormal_sex_gland	0.68197280
99	MP0000230_abnormal_systemic_arterial	0.64461274
100	MP0000427_abnormal_hair_cycle	0.63106388

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	5.41781518
2	Synostosis involving the elbow (HP:0003938)	4.14725955
3	Humeroradial synostosis (HP:0003041)	4.14725955
4	Acute necrotizing encephalopathy (HP:0006965)	4.13722598
5	Acute encephalopathy (HP:0006846)	3.65220390
6	Pancreatic cysts (HP:0001737)	3.59137707
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.57833220
8	Pancreatic fibrosis (HP:0100732)	3.55834802
9	Abnormality of alanine metabolism (HP:0010916)	3.53739902
10	Hyperalaninemia (HP:0003348)	3.53739902
11	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.53739902
12	Birth length less than 3rd percentile (HP:0003561)	3.38991927
13	True hermaphroditism (HP:0010459)	3.36382698
14	Colon cancer (HP:0003003)	3.32393046
15	Progressive macrocephaly (HP:0004481)	3.30619302
16	Abnormality of midbrain morphology (HP:0002418)	3.26413025
17	Molar tooth sign on MRI (HP:0002419)	3.26413025
18	Abnormality of the labia minora (HP:0012880)	3.24761324
19	Mitochondrial inheritance (HP:0001427)	3.18630015
20	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.09169962
21	Chorioretinal atrophy (HP:0000533)	3.09002137
22	Increased CSF lactate (HP:0002490)	3.07447827
23	Hypoplasia of the uterus (HP:0000013)	3.02057451
24	Nephronophthisis (HP:0000090)	2.97361736
25	Supernumerary spleens (HP:0009799)	2.94260217
26	Aplasia/hypoplasia of the uterus (HP:0008684)	2.89315106
27	Cerebral edema (HP:0002181)	2.80516154
28	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.79666005
29	Hyperglycinemia (HP:0002154)	2.77944456
30	Pendular nystagmus (HP:0012043)	2.75549028
31	Abnormal biliary tract physiology (HP:0012439)	2.61655110
32	Bile duct proliferation (HP:0001408)	2.61655110
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.57650976
34	Stomach cancer (HP:0012126)	2.44777710
35	Thyroid-stimulating hormone excess (HP:0002925)	2.41950220
36	Increased serum lactate (HP:0002151)	2.39848028
37	Lactic acidosis (HP:0003128)	2.31470872
38	Progressive inability to walk (HP:0002505)	2.27321145
39	Optic disc pallor (HP:0000543)	2.27212665
40	Hepatic necrosis (HP:0002605)	2.25956656
41	Methylmalonic acidemia (HP:0002912)	2.25138667
42	Microretrognathia (HP:0000308)	2.24280023
43	Abnormality of the renal medulla (HP:0100957)	2.23970231
44	Hepatocellular necrosis (HP:0001404)	2.23539296
45	Pigmentary retinal degeneration (HP:0001146)	2.23197983
46	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.22509682
47	Cystic liver disease (HP:0006706)	2.20806270
48	Brittle hair (HP:0002299)	2.18428961
49	Inability to walk (HP:0002540)	2.17988110
50	Abnormal respiratory epithelium morphology (HP:0012253)	2.17952636
51	Abnormal respiratory motile cilium morphology (HP:0005938)	2.17952636
52	CNS hypomyelination (HP:0003429)	2.15805868
53	Abnormality of serum amino acid levels (HP:0003112)	2.14817643
54	Patellar aplasia (HP:0006443)	2.12642873
55	Aplasia/Hypoplasia of the patella (HP:0006498)	2.11457753
56	Agitation (HP:0000713)	2.09066241
57	Ulnar claw (HP:0001178)	2.07320131
58	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.02555949
59	Abolished electroretinogram (ERG) (HP:0000550)	2.02186393
60	Stomatitis (HP:0010280)	2.01393965
61	Furrowed tongue (HP:0000221)	2.00313272
62	Absent/shortened dynein arms (HP:0200106)	1.99471598
63	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.99471598
64	Concave nail (HP:0001598)	1.99391873
65	IgG deficiency (HP:0004315)	1.98634773
66	Leukodystrophy (HP:0002415)	1.98503746
67	Abnormality of macular pigmentation (HP:0008002)	1.97735202
68	Breast hypoplasia (HP:0003187)	1.96876436
69	Abnormality of glycine metabolism (HP:0010895)	1.96622831
70	Abnormality of serine family amino acid metabolism (HP:0010894)	1.96622831
71	Renal cortical cysts (HP:0000803)	1.95712000
72	Anencephaly (HP:0002323)	1.95412377
73	Brushfield spots (HP:0001088)	1.94829359
74	Abnormality of methionine metabolism (HP:0010901)	1.94201290
75	Prostate neoplasm (HP:0100787)	1.91292988
76	Clumsiness (HP:0002312)	1.90629363
77	Female pseudohermaphroditism (HP:0010458)	1.88892809
78	Gaze-evoked nystagmus (HP:0000640)	1.87062836
79	Hypoproteinemia (HP:0003075)	1.86973791
80	Increased hepatocellular lipid droplets (HP:0006565)	1.86716821
81	Redundant skin (HP:0001582)	1.85917388
82	Occipital encephalocele (HP:0002085)	1.84979417
83	Delayed CNS myelination (HP:0002188)	1.84298689
84	Lethargy (HP:0001254)	1.81432397
85	Sclerocornea (HP:0000647)	1.80422338
86	Mesangial abnormality (HP:0001966)	1.79389587
87	Type 2 muscle fiber atrophy (HP:0003554)	1.78609098
88	Preaxial hand polydactyly (HP:0001177)	1.78511923
89	Chronic hepatic failure (HP:0100626)	1.78007700
90	Oculomotor apraxia (HP:0000657)	1.76037966
91	Methylmalonic aciduria (HP:0012120)	1.74721022
92	Male pseudohermaphroditism (HP:0000037)	1.73970881
93	Large for gestational age (HP:0001520)	1.73642934
94	Stenosis of the external auditory canal (HP:0000402)	1.73135860
95	Hyperglycinuria (HP:0003108)	1.72993222
96	Abnormal number of erythroid precursors (HP:0012131)	1.72660703
97	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.71718282
98	Gonadotropin excess (HP:0000837)	1.70769594
99	Abnormal glycosylation (HP:0012345)	1.70513764
100	Abnormal protein N-linked glycosylation (HP:0012347)	1.70513764

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.49592332
2	BMPR1B	3.30191403
3	ACVR1B	3.23880855
4	TLK1	3.22736358
5	ZAK	3.06207343
6	TAOK3	2.56942143
7	CAMKK2	2.50684149
8	WNK3	2.46235152
9	BUB1	2.32681718
10	NEK1	2.31200543
11	STK16	2.23783088
12	NUAK1	2.17974413
13	VRK2	2.06424896
14	TSSK6	2.02747756
15	TXK	1.91529386
16	TGFBR1	1.80496188
17	OXSR1	1.79081431
18	GRK1	1.79075165
19	BRSK2	1.73312258
20	ADRBK2	1.67521793
21	BCKDK	1.63033785
22	TIE1	1.54237476
23	MKNK1	1.51999437
24	TRIM28	1.48405113
25	CDK19	1.48118430
26	VRK1	1.47667095
27	FRK	1.42334116
28	PINK1	1.36377648
29	NME1	1.34022570
30	TEC	1.33790190
31	PLK3	1.25683575
32	MST4	1.18767213
33	CSNK1G3	1.17865224
34	SRPK1	1.15938550
35	PDK2	1.06904726
36	CSNK1G1	1.02821129
37	IKBKB	1.01567698
38	BCR	0.99464565
39	CSNK1A1L	0.98998829
40	MST1R	0.98257244
41	CSNK1G2	0.98177931
42	ITK	0.96036199
43	LIMK1	0.95917130
44	TNK2	0.92832092
45	MAP2K1	0.91299833
46	WNK4	0.87324102
47	STK39	0.86033071
48	MAP2K2	0.84306845
49	PHKG2	0.80465348
50	PHKG1	0.80465348
51	ERBB3	0.80083267
52	EIF2AK3	0.79752375
53	ADRBK1	0.78490058
54	CDC7	0.76545138
55	MKNK2	0.73139814
56	EIF2AK2	0.72766137
57	DYRK2	0.65231043
58	PLK4	0.64480635
59	CHUK	0.59594423
60	IRAK1	0.58606419
61	BTK	0.55740794
62	PAK3	0.55266760
63	SYK	0.54502540
64	FGFR2	0.52840841
65	PIK3CA	0.52478453
66	CASK	0.51866443
67	AURKB	0.49470450
68	IRAK4	0.48490832
69	DAPK2	0.48460986
70	PBK	0.47795257
71	PLK1	0.47534588
72	MAP2K6	0.46940859
73	IGF1R	0.46449132
74	RPS6KA4	0.45915770
75	TNIK	0.45617763
76	CSNK1E	0.44317044
77	MAP3K9	0.44279008
78	INSRR	0.44049122
79	ATR	0.43588124
80	ABL2	0.43248396
81	GRK5	0.42637970
82	GRK7	0.40261583
83	PRKCE	0.39433996
84	BRSK1	0.39421208
85	TAF1	0.38870522
86	PIM1	0.38656941
87	CSNK1D	0.36987710
88	SIK2	0.35261588
89	PRKCG	0.35134906
90	MAPKAPK5	0.34156054
91	RPS6KA5	0.33329653
92	CSNK2A1	0.33232097
93	ALK	0.32694091
94	MAP3K4	0.29798773
95	PRKCQ	0.29520851
96	CAMKK1	0.29058679
97	CAMK2A	0.28863493
98	PIK3CG	0.28790804
99	CSNK2A2	0.28550744
100	PRKAA1	0.28287428

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	RNA polymerase_Homo sapiens_hsa03020	3.53778055
2	Proteasome_Homo sapiens_hsa03050	3.52160316
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.09894660
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.69427477
5	Parkinsons disease_Homo sapiens_hsa05012	2.56856082
6	Ribosome_Homo sapiens_hsa03010	2.54846290
7	Protein export_Homo sapiens_hsa03060	2.42772828
8	Phototransduction_Homo sapiens_hsa04744	2.33833068
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.08871418
10	Propanoate metabolism_Homo sapiens_hsa00640	1.84826529
11	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.79015698
12	One carbon pool by folate_Homo sapiens_hsa00670	1.77258973
13	RNA degradation_Homo sapiens_hsa03018	1.77166839
14	Basal transcription factors_Homo sapiens_hsa03022	1.74443392
15	Huntingtons disease_Homo sapiens_hsa05016	1.73709190
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73134699
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.71637142
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.68266810
19	Homologous recombination_Homo sapiens_hsa03440	1.67045511
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.58574661
21	Mismatch repair_Homo sapiens_hsa03430	1.52435414
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.51887800
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.51435098
24	Sulfur metabolism_Homo sapiens_hsa00920	1.48203873
25	Alzheimers disease_Homo sapiens_hsa05010	1.47056819
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.43738638
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.42674847
28	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.41155046
29	Olfactory transduction_Homo sapiens_hsa04740	1.38632415
30	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.38482677
31	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.38041691
32	Spliceosome_Homo sapiens_hsa03040	1.36935041
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.36929459
34	Butanoate metabolism_Homo sapiens_hsa00650	1.36219175
35	Peroxisome_Homo sapiens_hsa04146	1.36115978
36	Nicotine addiction_Homo sapiens_hsa05033	1.36049065
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.35421233
38	Asthma_Homo sapiens_hsa05310	1.35195722
39	Purine metabolism_Homo sapiens_hsa00230	1.35105052
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.31315862
41	RNA transport_Homo sapiens_hsa03013	1.29257885
42	Caffeine metabolism_Homo sapiens_hsa00232	1.27537713
43	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.22801293
44	Non-homologous end-joining_Homo sapiens_hsa03450	1.20735016
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.19751998
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.19718618
47	Nucleotide excision repair_Homo sapiens_hsa03420	1.18412510
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.13132198
49	Ether lipid metabolism_Homo sapiens_hsa00565	1.01864845
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.00376464
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.98568150
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.98076418
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.96511927
54	DNA replication_Homo sapiens_hsa03030	0.94528098
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.89869905
56	Cardiac muscle contraction_Homo sapiens_hsa04260	0.89218597
57	Allograft rejection_Homo sapiens_hsa05330	0.87977254
58	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.87295094
59	Regulation of autophagy_Homo sapiens_hsa04140	0.82584938
60	Circadian rhythm_Homo sapiens_hsa04710	0.80184821
61	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.79193140
62	Type I diabetes mellitus_Homo sapiens_hsa04940	0.79009719
63	Fatty acid elongation_Homo sapiens_hsa00062	0.77904612
64	Base excision repair_Homo sapiens_hsa03410	0.77767200
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.76489783
66	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.75528040
67	Metabolic pathways_Homo sapiens_hsa01100	0.74775249
68	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.69549743
69	Primary immunodeficiency_Homo sapiens_hsa05340	0.68989317
70	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.68600813
71	Glutathione metabolism_Homo sapiens_hsa00480	0.64213596
72	Graft-versus-host disease_Homo sapiens_hsa05332	0.61696088
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59358370
74	Taste transduction_Homo sapiens_hsa04742	0.57661162
75	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.56356996
76	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.55470869
77	Fat digestion and absorption_Homo sapiens_hsa04975	0.55143516
78	Retinol metabolism_Homo sapiens_hsa00830	0.54894283
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.54516368
80	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.54298642
81	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54292421
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51485450
83	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.50412422
84	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47900518
85	Morphine addiction_Homo sapiens_hsa05032	0.47197424
86	p53 signaling pathway_Homo sapiens_hsa04115	0.45112404
87	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.42469682
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42123961
89	Rheumatoid arthritis_Homo sapiens_hsa05323	0.38592900
90	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.37892757
91	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.37350418
92	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.37125519
93	Pyruvate metabolism_Homo sapiens_hsa00620	0.35055925
94	Carbon metabolism_Homo sapiens_hsa01200	0.34114821
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.34025562
96	Serotonergic synapse_Homo sapiens_hsa04726	0.32694238
97	Folate biosynthesis_Homo sapiens_hsa00790	0.32641858
98	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.31497884
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.28738906
100	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.28370230

HNRNPA1P20

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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