ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.36957476
2	regulation of cilium movement (GO:0003352)	4.24529610
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.98765310
4	ATP synthesis coupled proton transport (GO:0015986)	3.98765310
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.92352072
6	water-soluble vitamin biosynthetic process (GO:0042364)	3.90202066
7	protein neddylation (GO:0045116)	3.81558145
8	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.64589974
9	proteasome assembly (GO:0043248)	3.63127255
10	sequestering of actin monomers (GO:0042989)	3.59767450
11	platelet dense granule organization (GO:0060155)	3.59525268
12	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.59083931
13	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.59083931
14	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.58740174
15	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.58740174
16	NADH dehydrogenase complex assembly (GO:0010257)	3.58740174
17	cullin deneddylation (GO:0010388)	3.56185303
18	chaperone-mediated protein transport (GO:0072321)	3.52428331
19	ubiquinone metabolic process (GO:0006743)	3.50315311
20	ubiquinone biosynthetic process (GO:0006744)	3.47573407
21	protein deneddylation (GO:0000338)	3.46280957
22	cytidine metabolic process (GO:0046087)	3.45941688
23	cytidine catabolic process (GO:0006216)	3.45941688
24	cytidine deamination (GO:0009972)	3.45941688
25	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.45707823
26	mannosylation (GO:0097502)	3.34852443
27	behavioral response to nicotine (GO:0035095)	3.31014296
28	protein complex biogenesis (GO:0070271)	3.31010474
29	mitochondrial respiratory chain complex assembly (GO:0033108)	3.27893288
30	cellular response to interleukin-15 (GO:0071350)	3.27527419
31	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.26426143
32	GPI anchor metabolic process (GO:0006505)	3.20542818
33	mast cell degranulation (GO:0043303)	3.18449757
34	mast cell activation involved in immune response (GO:0002279)	3.18449757
35	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.18274302
36	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.15851798
37	ribosomal small subunit assembly (GO:0000028)	3.12354690
38	termination of RNA polymerase III transcription (GO:0006386)	3.09082807
39	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.09082807
40	L-fucose catabolic process (GO:0042355)	3.07201362
41	fucose catabolic process (GO:0019317)	3.07201362
42	L-fucose metabolic process (GO:0042354)	3.07201362
43	pseudouridine synthesis (GO:0001522)	3.05798062
44	peptidyl-histidine modification (GO:0018202)	3.04874524
45	base-excision repair, AP site formation (GO:0006285)	3.03684820
46	regulation of chronic inflammatory response (GO:0002676)	3.03474305
47	respiratory chain complex IV assembly (GO:0008535)	3.01104189
48	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.00876975
49	sleep (GO:0030431)	2.99127297
50	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.96943198
51	GPI anchor biosynthetic process (GO:0006506)	2.96280524
52	DNA damage response, detection of DNA damage (GO:0042769)	2.91141702
53	S-adenosylmethionine metabolic process (GO:0046500)	2.89136989
54	estrogen biosynthetic process (GO:0006703)	2.86187661
55	rRNA catabolic process (GO:0016075)	2.85861531
56	maturation of 5.8S rRNA (GO:0000460)	2.85340786
57	iron-sulfur cluster assembly (GO:0016226)	2.83029178
58	metallo-sulfur cluster assembly (GO:0031163)	2.83029178
59	electron transport chain (GO:0022900)	2.82346411
60	quinone biosynthetic process (GO:1901663)	2.81706293
61	indolalkylamine metabolic process (GO:0006586)	2.81488080
62	respiratory electron transport chain (GO:0022904)	2.78683092
63	mast cell activation (GO:0045576)	2.78331593
64	positive regulation of defense response to virus by host (GO:0002230)	2.78190747
65	rRNA modification (GO:0000154)	2.75560988
66	negative regulation of mast cell activation (GO:0033004)	2.69146513
67	amino acid salvage (GO:0043102)	2.68379197
68	L-methionine salvage (GO:0071267)	2.68379197
69	L-methionine biosynthetic process (GO:0071265)	2.68379197
70	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.67756204
71	signal peptide processing (GO:0006465)	2.67425380
72	cytochrome complex assembly (GO:0017004)	2.65528790
73	intracellular protein transmembrane import (GO:0044743)	2.64909776
74	negative regulation of heart rate (GO:0010459)	2.63856721
75	preassembly of GPI anchor in ER membrane (GO:0016254)	2.61110282
76	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.60911221
77	tRNA processing (GO:0008033)	2.60023760
78	tryptophan metabolic process (GO:0006568)	2.58501997
79	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.57474834
80	regulation of mitotic spindle checkpoint (GO:1903504)	2.57474834
81	DNA catabolic process, exonucleolytic (GO:0000738)	2.56516898
82	GTP biosynthetic process (GO:0006183)	2.54904720
83	DNA demethylation (GO:0080111)	2.53625936
84	kynurenine metabolic process (GO:0070189)	2.53344704
85	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.52810119
86	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.48579406
87	positive regulation of prostaglandin secretion (GO:0032308)	2.47417574
88	isoprenoid biosynthetic process (GO:0008299)	2.45582003
89	protein prenylation (GO:0018342)	2.45107064
90	prenylation (GO:0097354)	2.45107064
91	histone mRNA metabolic process (GO:0008334)	2.44908243
92	adenosine metabolic process (GO:0046085)	2.41976769
93	regulation of cellular amino acid metabolic process (GO:0006521)	2.41940111
94	chromatin remodeling at centromere (GO:0031055)	2.41918948
95	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.41353720
96	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.39975456
97	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.38811336
98	regulation of hippo signaling (GO:0035330)	2.37914129
99	nonmotile primary cilium assembly (GO:0035058)	2.37552399
100	branched-chain amino acid catabolic process (GO:0009083)	2.35676702

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.98345768
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.91429428
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.65614982
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.10558211
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.09930982
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.01838101
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.93729412
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.65892671
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.61830838
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.59171460
11	VDR_22108803_ChIP-Seq_LS180_Human	2.48263371
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.48152737
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.47319237
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.43730588
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.30449158
16	MYC_18940864_ChIP-ChIP_HL60_Human	2.23812577
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.15547915
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.13830087
19	EWS_26573619_Chip-Seq_HEK293_Human	2.12987931
20	FOXP3_21729870_ChIP-Seq_TREG_Human	2.05829888
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.96895216
22	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.94195174
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.90401235
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.90302763
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.90142033
26	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.84534313
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82835959
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.82416163
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.74137174
30	FUS_26573619_Chip-Seq_HEK293_Human	1.73952341
31	P300_19829295_ChIP-Seq_ESCs_Human	1.70497043
32	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.70287963
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.66078724
34	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.64596839
35	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.61076420
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.58067601
37	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.57285358
38	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55557849
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.53316163
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49315344
41	AR_20517297_ChIP-Seq_VCAP_Human	1.47194450
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43734415
43	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43734415
44	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.42535367
45	ER_23166858_ChIP-Seq_MCF-7_Human	1.40975141
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.39842200
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.38679773
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.38679773
49	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.37914666
50	GATA3_26560356_Chip-Seq_TH2_Human	1.30736223
51	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.30484050
52	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.26282400
53	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.23873614
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.22185065
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.22185065
56	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.21661397
57	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.20949038
58	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.20913208
59	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.19294244
60	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.18546187
61	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.17248134
62	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.14769794
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14510408
64	GABP_19822575_ChIP-Seq_HepG2_Human	1.14001930
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12338128
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11539651
67	DCP1A_22483619_ChIP-Seq_HELA_Human	1.11025302
68	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08472541
69	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06587234
70	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05790824
71	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.05525203
72	NCOR_22424771_ChIP-Seq_293T_Human	1.04994170
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.04075891
74	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03592619
75	TAF2_19829295_ChIP-Seq_ESCs_Human	1.02408582
76	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.01629801
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01336361
78	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00240316
79	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99606215
80	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.99454152
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98581297
82	TCF4_22108803_ChIP-Seq_LS180_Human	0.97051563
83	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96576730
84	MYC_19829295_ChIP-Seq_ESCs_Human	0.96357836
85	ERG_20517297_ChIP-Seq_VCAP_Human	0.95878791
86	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.95773419
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95754050
88	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.95206987
89	CIITA_25753668_ChIP-Seq_RAJI_Human	0.92356904
90	AR_21572438_ChIP-Seq_LNCaP_Human	0.92002274
91	TTF2_22483619_ChIP-Seq_HELA_Human	0.91672419
92	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.91255054
93	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.91199943
94	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.90456265
95	GATA3_26560356_Chip-Seq_TH1_Human	0.90450578
96	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.90433074
97	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.90222871
98	GBX2_23144817_ChIP-Seq_PC3_Human	0.89629357
99	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.87184060
100	MYB_26560356_Chip-Seq_TH2_Human	0.86785550

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.71715392
2	MP0006072_abnormal_retinal_apoptosis	3.49677822
3	MP0002102_abnormal_ear_morphology	2.58907788
4	MP0006292_abnormal_olfactory_placode	2.34841299
5	MP0008875_abnormal_xenobiotic_pharmacok	2.33635727
6	MP0002876_abnormal_thyroid_physiology	2.28656033
7	MP0003724_increased_susceptibility_to	2.27751436
8	MP0009785_altered_susceptibility_to	2.17454341
9	MP0009697_abnormal_copulation	2.06284611
10	MP0008877_abnormal_DNA_methylation	2.05094441
11	MP0005253_abnormal_eye_physiology	2.02092586
12	MP0003567_abnormal_fetal_cardiomyocyte	2.01878338
13	MP0005645_abnormal_hypothalamus_physiol	2.00434549
14	MP0005551_abnormal_eye_electrophysiolog	1.94235143
15	MP0002166_altered_tumor_susceptibility	1.90376740
16	MP0003646_muscle_fatigue	1.89584525
17	MP0001529_abnormal_vocalization	1.87949332
18	MP0008872_abnormal_physiological_respon	1.86701783
19	MP0005646_abnormal_pituitary_gland	1.83555014
20	MP0001986_abnormal_taste_sensitivity	1.76884067
21	MP0003195_calcinosis	1.71659729
22	MP0006276_abnormal_autonomic_nervous	1.68564054
23	MP0002163_abnormal_gland_morphology	1.60171474
24	MP0002006_tumorigenesis	1.60071744
25	MP0009764_decreased_sensitivity_to	1.57015485
26	MP0008995_early_reproductive_senescence	1.53982802
27	MP0003011_delayed_dark_adaptation	1.53318662
28	MP0008789_abnormal_olfactory_epithelium	1.51128381
29	MP0002653_abnormal_ependyma_morphology	1.49959800
30	MP0002009_preneoplasia	1.49080504
31	MP0000372_irregular_coat_pigmentation	1.46690614
32	MP0001984_abnormal_olfaction	1.46332071
33	MP0002736_abnormal_nociception_after	1.45137933
34	MP0001873_stomach_inflammation	1.41675341
35	MP0003880_abnormal_central_pattern	1.41079991
36	MP0001501_abnormal_sleep_pattern	1.38836737
37	MP0002138_abnormal_hepatobiliary_system	1.38693636
38	MP0002234_abnormal_pharynx_morphology	1.38123943
39	MP0001800_abnormal_humoral_immune	1.37738730
40	MP0002148_abnormal_hypersensitivity_rea	1.36025437
41	MP0005000_abnormal_immune_tolerance	1.34780239
42	MP0005085_abnormal_gallbladder_physiolo	1.31073965
43	MP0004142_abnormal_muscle_tone	1.30065797
44	MP0008058_abnormal_DNA_repair	1.29965885
45	MP0004147_increased_porphyrin_level	1.26063683
46	MP0001919_abnormal_reproductive_system	1.25603498
47	MP0001485_abnormal_pinna_reflex	1.24186564
48	MP0001905_abnormal_dopamine_level	1.23060629
49	MP0002723_abnormal_immune_serum	1.22401504
50	MP0005379_endocrine/exocrine_gland_phen	1.21839238
51	MP0004145_abnormal_muscle_electrophysio	1.19005527
52	MP0003137_abnormal_impulse_conducting	1.15513738
53	MP0001968_abnormal_touch/_nociception	1.15484156
54	MP0006036_abnormal_mitochondrial_physio	1.14688320
55	MP0003786_premature_aging	1.12232931
56	MP0001764_abnormal_homeostasis	1.12215853
57	MP0005377_hearing/vestibular/ear_phenot	1.09833635
58	MP0003878_abnormal_ear_physiology	1.09833635
59	MP0001835_abnormal_antigen_presentation	1.09580047
60	MP0005084_abnormal_gallbladder_morpholo	1.08956300
61	MP0010386_abnormal_urinary_bladder	1.08430930
62	MP0004885_abnormal_endolymph	1.08351934
63	MP0005389_reproductive_system_phenotype	1.07191778
64	MP0003787_abnormal_imprinting	1.06233849
65	MP0009379_abnormal_foot_pigmentation	1.04094609
66	MP0005075_abnormal_melanosome_morpholog	1.03705689
67	MP0002452_abnormal_antigen_presenting	1.01520219
68	MP0003763_abnormal_thymus_physiology	1.01332112
69	MP0000631_abnormal_neuroendocrine_gland	1.00749995
70	MP0003693_abnormal_embryo_hatching	0.99805490
71	MP0003718_maternal_effect	0.99118722
72	MP0005332_abnormal_amino_acid	0.98992444
73	MP0000685_abnormal_immune_system	0.97168433
74	MP0001819_abnormal_immune_cell	0.96831018
75	MP0000049_abnormal_middle_ear	0.96779496
76	MP0002420_abnormal_adaptive_immunity	0.96022060
77	MP0002837_dystrophic_cardiac_calcinosis	0.95043638
78	MP0005387_immune_system_phenotype	0.89235786
79	MP0001790_abnormal_immune_system	0.89235786
80	MP0010155_abnormal_intestine_physiology	0.88560252
81	MP0005167_abnormal_blood-brain_barrier	0.87663883
82	MP0003436_decreased_susceptibility_to	0.85115522
83	MP0002751_abnormal_autonomic_nervous	0.83146785
84	MP0008775_abnormal_heart_ventricle	0.82944758
85	MP0004133_heterotaxia	0.82896037
86	MP0002254_reproductive_system_inflammat	0.82787591
87	MP0000613_abnormal_salivary_gland	0.82635773
88	MP0004742_abnormal_vestibular_system	0.81986721
89	MP0002272_abnormal_nervous_system	0.80279847
90	MP0005647_abnormal_sex_gland	0.80001647
91	MP0010094_abnormal_chromosome_stability	0.79206890
92	MP0005025_abnormal_response_to	0.78627323
93	MP0005195_abnormal_posterior_eye	0.77034321
94	MP0001293_anophthalmia	0.76092866
95	MP0003186_abnormal_redox_activity	0.75482052
96	MP0008469_abnormal_protein_level	0.75237639
97	MP0003938_abnormal_ear_development	0.75165044
98	MP0001845_abnormal_inflammatory_respons	0.74197260
99	MP0005499_abnormal_olfactory_system	0.73611379
100	MP0005394_taste/olfaction_phenotype	0.73611379

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Methylmalonic acidemia (HP:0002912)	3.65126718
2	IgG deficiency (HP:0004315)	3.50577593
3	Pancreatic cysts (HP:0001737)	3.29891636
4	Molar tooth sign on MRI (HP:0002419)	3.23741112
5	Abnormality of midbrain morphology (HP:0002418)	3.23741112
6	Hepatocellular necrosis (HP:0001404)	3.23529779
7	Acute necrotizing encephalopathy (HP:0006965)	3.18137634
8	Mitochondrial inheritance (HP:0001427)	3.15319892
9	True hermaphroditism (HP:0010459)	3.11815201
10	Pancreatic fibrosis (HP:0100732)	3.05934830
11	Severe combined immunodeficiency (HP:0004430)	3.02478478
12	Methylmalonic aciduria (HP:0012120)	3.02358476
13	3-Methylglutaconic aciduria (HP:0003535)	2.98748567
14	Hepatic necrosis (HP:0002605)	2.97516330
15	Abolished electroretinogram (ERG) (HP:0000550)	2.92471786
16	Increased CSF lactate (HP:0002490)	2.90426883
17	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.87525968
18	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.87525968
19	Type I transferrin isoform profile (HP:0003642)	2.84414919
20	Medial flaring of the eyebrow (HP:0010747)	2.83686890
21	Abnormal mitochondria in muscle tissue (HP:0008316)	2.81637543
22	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.78987867
23	Acute encephalopathy (HP:0006846)	2.75098832
24	Progressive macrocephaly (HP:0004481)	2.74317769
25	Nephronophthisis (HP:0000090)	2.72833776
26	Renal cortical cysts (HP:0000803)	2.70348140
27	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.64952343
28	Abnormality of alanine metabolism (HP:0010916)	2.64952343
29	Hyperalaninemia (HP:0003348)	2.64952343
30	Thyroiditis (HP:0100646)	2.63512979
31	Colon cancer (HP:0003003)	2.58114094
32	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.53604221
33	Abnormal protein N-linked glycosylation (HP:0012347)	2.53604221
34	Abnormal protein glycosylation (HP:0012346)	2.53604221
35	Abnormal glycosylation (HP:0012345)	2.53604221
36	Hypoproteinemia (HP:0003075)	2.51619167
37	Abnormality of the pons (HP:0007361)	2.48674987
38	Congenital, generalized hypertrichosis (HP:0004540)	2.45730891
39	Increased serum lactate (HP:0002151)	2.43488200
40	Increased hepatocellular lipid droplets (HP:0006565)	2.42847665
41	Congenital primary aphakia (HP:0007707)	2.41215512
42	Lipid accumulation in hepatocytes (HP:0006561)	2.41205332
43	Congenital stationary night blindness (HP:0007642)	2.40767843
44	Hyperglycinemia (HP:0002154)	2.39537652
45	Attenuation of retinal blood vessels (HP:0007843)	2.33449735
46	Type II lissencephaly (HP:0007260)	2.33388072
47	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.32489275
48	Reduced antithrombin III activity (HP:0001976)	2.31518240
49	Gait imbalance (HP:0002141)	2.29329434
50	Abnormality of the renal cortex (HP:0011035)	2.28962378
51	Combined immunodeficiency (HP:0005387)	2.28843277
52	Dicarboxylic aciduria (HP:0003215)	2.27385963
53	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.27385963
54	Abnormality of the renal medulla (HP:0100957)	2.25167872
55	Hypoplasia of the uterus (HP:0000013)	2.24869024
56	Stomach cancer (HP:0012126)	2.24133130
57	Aplasia/hypoplasia of the uterus (HP:0008684)	2.22436091
58	Constricted visual fields (HP:0001133)	2.21481847
59	Abnormality of serine family amino acid metabolism (HP:0010894)	2.20860341
60	Abnormality of glycine metabolism (HP:0010895)	2.20860341
61	Abnormality of the prostate (HP:0008775)	2.18958697
62	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.18849707
63	Stomatitis (HP:0010280)	2.18155430
64	Abnormality of vitamin B metabolism (HP:0004340)	2.16664199
65	Pendular nystagmus (HP:0012043)	2.16448458
66	Hypoplasia of the pons (HP:0012110)	2.16260948
67	Abnormal rod and cone electroretinograms (HP:0008323)	2.16054858
68	Optic disc pallor (HP:0000543)	2.11714512
69	Cerebral edema (HP:0002181)	2.10614011
70	T lymphocytopenia (HP:0005403)	2.09610192
71	Nephrogenic diabetes insipidus (HP:0009806)	2.09606149
72	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.08970146
73	CNS demyelination (HP:0007305)	2.06967124
74	Abnormality of the ileum (HP:0001549)	2.04819476
75	Abnormality of eosinophils (HP:0001879)	2.04418991
76	Pancytopenia (HP:0001876)	2.04109693
77	Asplenia (HP:0001746)	2.02069897
78	Inability to walk (HP:0002540)	2.01659815
79	Lactic acidosis (HP:0003128)	2.01035019
80	Meckel diverticulum (HP:0002245)	2.00559952
81	Aplastic anemia (HP:0001915)	1.98697956
82	Decreased central vision (HP:0007663)	1.96804479
83	Hyperglycinuria (HP:0003108)	1.96736536
84	Lethargy (HP:0001254)	1.96164542
85	Abnormality of serum amino acid levels (HP:0003112)	1.95512565
86	Increased intramyocellular lipid droplets (HP:0012240)	1.94844616
87	Abnormality of B cell number (HP:0010975)	1.94662659
88	Opisthotonus (HP:0002179)	1.93181443
89	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.92755990
90	Sclerocornea (HP:0000647)	1.92646153
91	B lymphocytopenia (HP:0010976)	1.92523248
92	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.86896423
93	Abnormality of T cell number (HP:0011839)	1.86890419
94	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.86812266
95	Retinal dysplasia (HP:0007973)	1.83851944
96	Cystic liver disease (HP:0006706)	1.81236363
97	Abnormality of the renal collecting system (HP:0004742)	1.80999797
98	Brushfield spots (HP:0001088)	1.79035928
99	Poor head control (HP:0002421)	1.77136883
100	Large for gestational age (HP:0001520)	1.76602247

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.43204012
2	TLK1	3.82038681
3	ZAK	3.77321821
4	TAOK3	3.34512698
5	TXK	2.67618236
6	BCKDK	2.52060198
7	NUAK1	2.30249752
8	FRK	2.29780865
9	VRK2	2.23543319
10	GRK1	2.17891371
11	ADRBK2	2.05887759
12	BMPR1B	2.04913682
13	VRK1	2.04297872
14	MST4	2.01162860
15	NEK1	1.99517454
16	WNK3	1.81311845
17	TRIM28	1.69809247
18	BUB1	1.55875979
19	ERBB3	1.43957754
20	KDR	1.41941967
21	MKNK1	1.41781461
22	CSNK1G3	1.41310261
23	SRPK1	1.34878142
24	TESK2	1.25461571
25	TSSK6	1.24616749
26	WNK4	1.22526280
27	CSNK1G2	1.21336781
28	IKBKB	1.20067965
29	BMPR2	1.19001928
30	CSNK1G1	1.18956506
31	CSNK1A1L	1.14957547
32	KIT	1.12253919
33	INSRR	1.09916598
34	BCR	1.08749169
35	IKBKE	1.07760603
36	EPHA4	1.03394057
37	STK16	1.02907250
38	TIE1	1.00727807
39	PKN1	0.95164750
40	OXSR1	0.94122153
41	FES	0.93436934
42	PLK3	0.93154431
43	GRK6	0.90881873
44	MAP3K14	0.90780308
45	DYRK2	0.88491065
46	PINK1	0.86308957
47	CDK8	0.84550778
48	FLT3	0.84291310
49	PLK4	0.84126241
50	PLK2	0.81300582
51	MAP2K2	0.81047520
52	NME1	0.77225608
53	RPS6KA5	0.74445091
54	RPS6KA4	0.72933583
55	EPHA3	0.72323231
56	MAP3K4	0.69847564
57	EIF2AK3	0.69102074
58	MAP3K12	0.64262090
59	MAP2K7	0.62834590
60	PIK3CG	0.60515605
61	TEC	0.59103673
62	SYK	0.55942206
63	TGFBR1	0.53963732
64	PRKCQ	0.53527916
65	CSF1R	0.52395821
66	MATK	0.51666204
67	DYRK1B	0.51573393
68	JAK3	0.50530030
69	AURKB	0.48929378
70	IGF1R	0.48030646
71	TNK2	0.47521104
72	LYN	0.46920685
73	PLK1	0.46707621
74	PBK	0.46666497
75	DAPK1	0.46545083
76	MAPK13	0.46184813
77	MAP4K1	0.46179253
78	ITK	0.46046269
79	TNIK	0.46025472
80	CDK19	0.45994001
81	CSNK1A1	0.45320441
82	PRKCE	0.45149997
83	ATR	0.45120762
84	ADRBK1	0.44330837
85	LCK	0.41761583
86	PIM1	0.41021462
87	DAPK2	0.40975000
88	STK38L	0.40721159
89	MUSK	0.40102004
90	STK39	0.39899895
91	MAPKAPK5	0.39498203
92	CSNK2A1	0.36922277
93	OBSCN	0.35493619
94	EIF2AK2	0.35267105
95	TBK1	0.34767599
96	LIMK1	0.34349733
97	NEK2	0.34290450
98	PRKACA	0.30757260
99	JAK1	0.29851078
100	SIK3	0.29069594

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.01041401
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.88116652
3	Asthma_Homo sapiens_hsa05310	2.53144663
4	Protein export_Homo sapiens_hsa03060	2.47809756
5	RNA polymerase_Homo sapiens_hsa03020	2.42890010
6	Primary immunodeficiency_Homo sapiens_hsa05340	2.42870659
7	Ribosome_Homo sapiens_hsa03010	2.39020394
8	Parkinsons disease_Homo sapiens_hsa05012	2.32073528
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.27855236
10	Homologous recombination_Homo sapiens_hsa03440	2.22197558
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.17579563
12	Allograft rejection_Homo sapiens_hsa05330	2.07747782
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.02566992
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.99326049
15	Graft-versus-host disease_Homo sapiens_hsa05332	1.95566651
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.94356374
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.78081669
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.76464782
19	Type I diabetes mellitus_Homo sapiens_hsa04940	1.71319947
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.65520533
21	RNA degradation_Homo sapiens_hsa03018	1.58909929
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.55739785
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.54544417
24	Sulfur metabolism_Homo sapiens_hsa00920	1.51854864
25	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.49745824
26	Antigen processing and presentation_Homo sapiens_hsa04612	1.45353710
27	Huntingtons disease_Homo sapiens_hsa05016	1.42210947
28	Propanoate metabolism_Homo sapiens_hsa00640	1.41459136
29	Spliceosome_Homo sapiens_hsa03040	1.39747777
30	One carbon pool by folate_Homo sapiens_hsa00670	1.39613739
31	Phototransduction_Homo sapiens_hsa04744	1.37070448
32	Alzheimers disease_Homo sapiens_hsa05010	1.35491513
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.33940838
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.33671127
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.33341301
36	Peroxisome_Homo sapiens_hsa04146	1.31595740
37	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.25766282
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.23995863
39	Basal transcription factors_Homo sapiens_hsa03022	1.21997166
40	Mismatch repair_Homo sapiens_hsa03430	1.19704278
41	Base excision repair_Homo sapiens_hsa03410	1.17235928
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.14653022
43	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.03995914
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.03378496
45	Butanoate metabolism_Homo sapiens_hsa00650	1.03057108
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02943636
47	Purine metabolism_Homo sapiens_hsa00230	0.99045106
48	Rheumatoid arthritis_Homo sapiens_hsa05323	0.96933604
49	Cardiac muscle contraction_Homo sapiens_hsa04260	0.94444505
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.92938795
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.91778965
52	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.90812345
53	Caffeine metabolism_Homo sapiens_hsa00232	0.86969337
54	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.86517655
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.83036119
56	RNA transport_Homo sapiens_hsa03013	0.81149924
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.81146933
58	Retinol metabolism_Homo sapiens_hsa00830	0.81028685
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.80919698
60	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.79954879
61	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.78162373
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.77783858
63	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.76455740
64	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.75991255
65	Nucleotide excision repair_Homo sapiens_hsa03420	0.75401829
66	DNA replication_Homo sapiens_hsa03030	0.74985919
67	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.73526083
68	Steroid biosynthesis_Homo sapiens_hsa00100	0.72148753
69	Olfactory transduction_Homo sapiens_hsa04740	0.69785722
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.68227967
71	Metabolic pathways_Homo sapiens_hsa01100	0.67884947
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67850056
73	Sulfur relay system_Homo sapiens_hsa04122	0.67021593
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66763947
75	Nicotine addiction_Homo sapiens_hsa05033	0.66559677
76	Fatty acid degradation_Homo sapiens_hsa00071	0.65362435
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63783978
78	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63778911
79	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60661601
80	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58437564
81	Collecting duct acid secretion_Homo sapiens_hsa04966	0.57453339
82	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.57425503
83	Non-homologous end-joining_Homo sapiens_hsa03450	0.56788628
84	Taste transduction_Homo sapiens_hsa04742	0.55752721
85	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.55599443
86	Fat digestion and absorption_Homo sapiens_hsa04975	0.53533773
87	Pyruvate metabolism_Homo sapiens_hsa00620	0.53201953
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.52609910
89	Folate biosynthesis_Homo sapiens_hsa00790	0.52569896
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51396743
91	Histidine metabolism_Homo sapiens_hsa00340	0.49822609
92	Herpes simplex infection_Homo sapiens_hsa05168	0.48263676
93	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.47069398
94	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47063006
95	Viral myocarditis_Homo sapiens_hsa05416	0.43474082
96	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.41624074
97	Salivary secretion_Homo sapiens_hsa04970	0.40138333
98	Selenocompound metabolism_Homo sapiens_hsa00450	0.35966135
99	Regulation of autophagy_Homo sapiens_hsa04140	0.35024635
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.34490281

HNRNPA1P22

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »