ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.31594489
2	regulation of germinal center formation (GO:0002634)	4.16358570
3	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.97826976
4	isotype switching (GO:0045190)	3.97826976
5	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.97826976
6	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.96885293
7	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.90564903
8	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.74218948
9	positive regulation of defense response to virus by host (GO:0002230)	3.72845254
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.63294706
11	ATP synthesis coupled proton transport (GO:0015986)	3.63294706
12	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.61999248
13	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.59145206
14	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.58824731
15	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.53370149
16	behavioral response to nicotine (GO:0035095)	3.48250823
17	ribosomal small subunit assembly (GO:0000028)	3.45872548
18	regulation of cilium movement (GO:0003352)	3.43562768
19	protein polyglutamylation (GO:0018095)	3.42760386
20	protein-cofactor linkage (GO:0018065)	3.40102279
21	rRNA modification (GO:0000154)	3.38282930
22	water-soluble vitamin biosynthetic process (GO:0042364)	3.37621531
23	somatic diversification of immunoglobulins (GO:0016445)	3.36626293
24	positive regulation of T cell differentiation in thymus (GO:0033089)	3.34414261
25	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.33380876
26	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.33380876
27	cellular response to exogenous dsRNA (GO:0071360)	3.32274081
28	pseudouridine synthesis (GO:0001522)	3.26780099
29	DNA ligation (GO:0006266)	3.25269172
30	preassembly of GPI anchor in ER membrane (GO:0016254)	3.24155469
31	mannosylation (GO:0097502)	3.21141397
32	regulation of mitotic spindle checkpoint (GO:1903504)	3.13761331
33	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.13761331
34	tRNA processing (GO:0008033)	3.05672032
35	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.03499301
36	termination of RNA polymerase III transcription (GO:0006386)	3.03499301
37	ribosome assembly (GO:0042255)	3.02882574
38	maturation of 5.8S rRNA (GO:0000460)	2.95561077
39	aspartate family amino acid catabolic process (GO:0009068)	2.94894370
40	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.94888257
41	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.94791960
42	rRNA methylation (GO:0031167)	2.93333010
43	rRNA catabolic process (GO:0016075)	2.89487522
44	regulation of defense response to virus by host (GO:0050691)	2.87070079
45	somatic diversification of immune receptors (GO:0002200)	2.86014959
46	protein K6-linked ubiquitination (GO:0085020)	2.85699045
47	estrogen biosynthetic process (GO:0006703)	2.85661294
48	organelle disassembly (GO:1903008)	2.84455811
49	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.83499049
50	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.81180426
51	inositol phosphate dephosphorylation (GO:0046855)	2.81180426
52	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.79545799
53	protein complex biogenesis (GO:0070271)	2.76355041
54	fucose catabolic process (GO:0019317)	2.75340290
55	L-fucose metabolic process (GO:0042354)	2.75340290
56	L-fucose catabolic process (GO:0042355)	2.75340290
57	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.75025550
58	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.75025550
59	NADH dehydrogenase complex assembly (GO:0010257)	2.75025550
60	protein deneddylation (GO:0000338)	2.73464790
61	nucleobase biosynthetic process (GO:0046112)	2.72931660
62	regulation of memory T cell differentiation (GO:0043380)	2.72279877
63	positive regulation of RNA splicing (GO:0033120)	2.72135124
64	cullin deneddylation (GO:0010388)	2.71633628
65	positive regulation of prostaglandin secretion (GO:0032308)	2.70780851
66	respiratory chain complex IV assembly (GO:0008535)	2.69859399
67	regulation of T cell receptor signaling pathway (GO:0050856)	2.68053583
68	piRNA metabolic process (GO:0034587)	2.67232318
69	proteasome assembly (GO:0043248)	2.66266510
70	ribosomal large subunit biogenesis (GO:0042273)	2.64858255
71	DNA replication checkpoint (GO:0000076)	2.64290372
72	mitochondrial respiratory chain complex assembly (GO:0033108)	2.63939733
73	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.62769958
74	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.62769958
75	regulation of microtubule-based movement (GO:0060632)	2.61516487
76	ubiquinone biosynthetic process (GO:0006744)	2.60763276
77	tRNA metabolic process (GO:0006399)	2.59475397
78	inositol phosphate catabolic process (GO:0071545)	2.59201376
79	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.57137473
80	purine nucleobase biosynthetic process (GO:0009113)	2.56913006
81	chaperone-mediated protein transport (GO:0072321)	2.55369229
82	spliceosomal complex assembly (GO:0000245)	2.54982714
83	cytidine deamination (GO:0009972)	2.54014021
84	cytidine metabolic process (GO:0046087)	2.54014021
85	cytidine catabolic process (GO:0006216)	2.54014021
86	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.52551660
87	somatic cell DNA recombination (GO:0016444)	2.52323782
88	somatic diversification of immune receptors via germline recombination within a single locus (GO:000	2.52323782
89	rRNA metabolic process (GO:0016072)	2.50998236
90	positive regulation of mitochondrial fission (GO:0090141)	2.49597115
91	cytochrome complex assembly (GO:0017004)	2.49401115
92	adenosine metabolic process (GO:0046085)	2.49329355
93	rRNA processing (GO:0006364)	2.48662070
94	mitochondrial RNA metabolic process (GO:0000959)	2.47763407
95	kynurenine metabolic process (GO:0070189)	2.46744540
96	S-adenosylmethionine metabolic process (GO:0046500)	2.46619165
97	cellular ketone body metabolic process (GO:0046950)	2.46080171
98	ubiquinone metabolic process (GO:0006743)	2.45772655
99	GMP metabolic process (GO:0046037)	2.45532552
100	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.43887043

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.12395149
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.08182387
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.30624495
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.06250824
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.92644463
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.83448375
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.81551654
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.81383078
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.78003218
10	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.77290465
11	VDR_22108803_ChIP-Seq_LS180_Human	2.76791907
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.73114587
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.67459655
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.55029131
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.26770609
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.22572350
17	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.21607934
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.18649514
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.16721099
20	FOXP3_21729870_ChIP-Seq_TREG_Human	2.15383011
21	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.14360366
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.94279433
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.87492695
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.85927086
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.79162542
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77868337
27	IGF1R_20145208_ChIP-Seq_DFB_Human	1.75798343
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.75707009
29	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.70294995
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.67580302
31	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.64489507
32	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.63593480
33	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.62370171
34	EWS_26573619_Chip-Seq_HEK293_Human	1.61560788
35	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.58227167
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.57202543
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53052867
38	E2F7_22180533_ChIP-Seq_HELA_Human	1.49590631
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.49067832
40	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.47396655
41	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.44593845
42	TAF15_26573619_Chip-Seq_HEK293_Human	1.44241477
43	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.43285929
44	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.42802213
45	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.39861201
46	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.36383670
47	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.35165487
48	FUS_26573619_Chip-Seq_HEK293_Human	1.33738378
49	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.31382050
50	ER_23166858_ChIP-Seq_MCF-7_Human	1.30099763
51	GATA3_26560356_Chip-Seq_TH2_Human	1.29941795
52	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.29295725
53	AR_20517297_ChIP-Seq_VCAP_Human	1.29263028
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.28821367
55	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.24007142
56	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.23787729
57	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.23111150
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22069252
59	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.20668062
60	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.19247553
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18999668
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.18999668
63	P300_19829295_ChIP-Seq_ESCs_Human	1.17921841
64	TTF2_22483619_ChIP-Seq_HELA_Human	1.16508608
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16086370
66	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16086370
67	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.15979457
68	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.15953311
69	DCP1A_22483619_ChIP-Seq_HELA_Human	1.13456333
70	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.11860499
71	GABP_19822575_ChIP-Seq_HepG2_Human	1.11771193
72	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.09413392
73	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08893164
74	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.08531043
75	NCOR_22424771_ChIP-Seq_293T_Human	1.08279674
76	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.07994433
77	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.07289316
78	BCAT_22108803_ChIP-Seq_LS180_Human	1.07092845
79	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.06502378
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.04852080
81	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.04013697
82	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03154456
83	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03154456
84	GATA1_22025678_ChIP-Seq_K562_Human	1.02521053
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.01738327
86	STAT1_20625510_ChIP-Seq_HELA_Human	0.98530078
87	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.98035293
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97842172
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96505803
90	HOXB7_26014856_ChIP-Seq_BT474_Human	0.96095025
91	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95006593
92	MYB_26560356_Chip-Seq_TH2_Human	0.94720681
93	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.94329539
94	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.94253231
95	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.94079287
96	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.93210041
97	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92905714
98	NANOG_20526341_ChIP-Seq_ESCs_Human	0.92188448
99	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.91507698
100	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.90899656

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.78551607
2	MP0008877_abnormal_DNA_methylation	3.25215427
3	MP0006072_abnormal_retinal_apoptosis	3.06590656
4	MP0003011_delayed_dark_adaptation	3.02863372
5	MP0000372_irregular_coat_pigmentation	2.73248837
6	MP0008058_abnormal_DNA_repair	2.64128260
7	MP0002837_dystrophic_cardiac_calcinosis	2.57153157
8	MP0003786_premature_aging	2.38066049
9	MP0008995_early_reproductive_senescence	2.31677531
10	MP0005671_abnormal_response_to	2.29228855
11	MP0003806_abnormal_nucleotide_metabolis	2.11737659
12	MP0004147_increased_porphyrin_level	2.10578133
13	MP0005646_abnormal_pituitary_gland	2.10381991
14	MP0005253_abnormal_eye_physiology	1.92906825
15	MP0006292_abnormal_olfactory_placode	1.90845530
16	MP0005551_abnormal_eye_electrophysiolog	1.86403777
17	MP0001986_abnormal_taste_sensitivity	1.85249809
18	MP0003646_muscle_fatigue	1.82857759
19	MP0004145_abnormal_muscle_electrophysio	1.79577100
20	MP0003186_abnormal_redox_activity	1.75522972
21	MP0008872_abnormal_physiological_respon	1.72354191
22	MP0008875_abnormal_xenobiotic_pharmacok	1.66604543
23	MP0002876_abnormal_thyroid_physiology	1.64882328
24	MP0001529_abnormal_vocalization	1.59046648
25	MP0005075_abnormal_melanosome_morpholog	1.55307164
26	MP0008775_abnormal_heart_ventricle	1.53541505
27	MP0002148_abnormal_hypersensitivity_rea	1.51737152
28	MP0001835_abnormal_antigen_presentation	1.50796916
29	MP0006036_abnormal_mitochondrial_physio	1.49215856
30	MP0001919_abnormal_reproductive_system	1.49046946
31	MP0006035_abnormal_mitochondrial_morpho	1.48650798
32	MP0005645_abnormal_hypothalamus_physiol	1.47947076
33	MP0010094_abnormal_chromosome_stability	1.43881560
34	MP0003718_maternal_effect	1.43223344
35	MP0006276_abnormal_autonomic_nervous	1.39598667
36	MP0001293_anophthalmia	1.37869383
37	MP0002938_white_spotting	1.34420892
38	MP0009697_abnormal_copulation	1.33681218
39	MP0005389_reproductive_system_phenotype	1.32904833
40	MP0002277_abnormal_respiratory_mucosa	1.30521087
41	MP0005000_abnormal_immune_tolerance	1.29825498
42	MP0001800_abnormal_humoral_immune	1.29665971
43	MP0001440_abnormal_grooming_behavior	1.29206730
44	MP0009785_altered_susceptibility_to	1.23718764
45	MP0001968_abnormal_touch/_nociception	1.18180865
46	MP0001984_abnormal_olfaction	1.16213789
47	MP0005377_hearing/vestibular/ear_phenot	1.15796150
48	MP0003878_abnormal_ear_physiology	1.15796150
49	MP0008789_abnormal_olfactory_epithelium	1.14770349
50	MP0003638_abnormal_response/metabolism_	1.11234551
51	MP0005084_abnormal_gallbladder_morpholo	1.11095150
52	MP0002166_altered_tumor_susceptibility	1.10361943
53	MP0004215_abnormal_myocardial_fiber	1.10190773
54	MP0005167_abnormal_blood-brain_barrier	1.09909759
55	MP0001501_abnormal_sleep_pattern	1.09564533
56	MP0002736_abnormal_nociception_after	1.09421501
57	MP0004142_abnormal_muscle_tone	1.07434161
58	MP0002723_abnormal_immune_serum	1.06352635
59	MP0002452_abnormal_antigen_presenting	1.04927874
60	MP0003195_calcinosis	1.04815536
61	MP0004885_abnormal_endolymph	1.04271771
62	MP0003283_abnormal_digestive_organ	1.02757534
63	MP0004742_abnormal_vestibular_system	1.02651255
64	MP0003252_abnormal_bile_duct	1.02077434
65	MP0001486_abnormal_startle_reflex	0.97293273
66	MP0003567_abnormal_fetal_cardiomyocyte	0.96215308
67	MP0002733_abnormal_thermal_nociception	0.95299290
68	MP0002638_abnormal_pupillary_reflex	0.95013767
69	MP0003724_increased_susceptibility_to	0.94507124
70	MP0001819_abnormal_immune_cell	0.91865131
71	MP0002272_abnormal_nervous_system	0.90762103
72	MP0002006_tumorigenesis	0.90617875
73	MP0009764_decreased_sensitivity_to	0.90284147
74	MP0002160_abnormal_reproductive_system	0.89871180
75	MP0002420_abnormal_adaptive_immunity	0.89620620
76	MP0000689_abnormal_spleen_morphology	0.89371638
77	MP0001764_abnormal_homeostasis	0.89234651
78	MP0002009_preneoplasia	0.89183705
79	MP0001905_abnormal_dopamine_level	0.88600195
80	MP0005410_abnormal_fertilization	0.88179377
81	MP0003111_abnormal_nucleus_morphology	0.87820741
82	MP0002139_abnormal_hepatobiliary_system	0.85921586
83	MP0005085_abnormal_gallbladder_physiolo	0.85365153
84	MP0004957_abnormal_blastocyst_morpholog	0.85068377
85	MP0003693_abnormal_embryo_hatching	0.84968770
86	MP0003436_decreased_susceptibility_to	0.84138635
87	MP0001485_abnormal_pinna_reflex	0.83589675
88	MP0010155_abnormal_intestine_physiology	0.82295633
89	MP0000013_abnormal_adipose_tissue	0.81256992
90	MP0000647_abnormal_sebaceous_gland	0.80931948
91	MP0002751_abnormal_autonomic_nervous	0.79742902
92	MP0000427_abnormal_hair_cycle	0.79543575
93	MP0004043_abnormal_pH_regulation	0.78766673
94	MP0003866_abnormal_defecation	0.78235351
95	MP0000383_abnormal_hair_follicle	0.78205045
96	MP0009745_abnormal_behavioral_response	0.77990701
97	MP0002398_abnormal_bone_marrow	0.74371362
98	MP0001929_abnormal_gametogenesis	0.73291896
99	MP0000230_abnormal_systemic_arterial	0.71847820
100	MP0006054_spinal_hemorrhage	0.71109405

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abolished electroretinogram (ERG) (HP:0000550)	3.90815121
2	IgG deficiency (HP:0004315)	3.72896086
3	Nephronophthisis (HP:0000090)	3.43697917
4	Acute necrotizing encephalopathy (HP:0006965)	3.21919657
5	Elevated erythrocyte sedimentation rate (HP:0003565)	3.20724049
6	Pancreatic cysts (HP:0001737)	3.19400046
7	Stomatitis (HP:0010280)	3.12658391
8	Severe combined immunodeficiency (HP:0004430)	3.11082993
9	Molar tooth sign on MRI (HP:0002419)	3.10747306
10	Abnormality of midbrain morphology (HP:0002418)	3.10747306
11	Dyschromatopsia (HP:0007641)	3.06545274
12	Pancreatic fibrosis (HP:0100732)	2.99932540
13	True hermaphroditism (HP:0010459)	2.95631677
14	Mitochondrial inheritance (HP:0001427)	2.95614012
15	Acute encephalopathy (HP:0006846)	2.92050348
16	Progressive macrocephaly (HP:0004481)	2.89577505
17	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.89440139
18	Methylmalonic acidemia (HP:0002912)	2.82128021
19	Type 2 muscle fiber atrophy (HP:0003554)	2.80557699
20	Abnormal mitochondria in muscle tissue (HP:0008316)	2.76812164
21	Increased CSF lactate (HP:0002490)	2.73028195
22	Abnormality of the prostate (HP:0008775)	2.65770486
23	Abnormality of the renal medulla (HP:0100957)	2.59931849
24	Thyroiditis (HP:0100646)	2.57754524
25	Retinal dysplasia (HP:0007973)	2.51271380
26	Type I transferrin isoform profile (HP:0003642)	2.48278844
27	Methylmalonic aciduria (HP:0012120)	2.42646838
28	Combined immunodeficiency (HP:0005387)	2.42445522
29	Optic disc pallor (HP:0000543)	2.41193654
30	Chronic hepatic failure (HP:0100626)	2.39734805
31	Renal cortical cysts (HP:0000803)	2.39325831
32	Muscle fiber atrophy (HP:0100295)	2.28162964
33	Congenital stationary night blindness (HP:0007642)	2.27399882
34	Abnormal hemoglobin (HP:0011902)	2.27218798
35	Abnormal respiratory motile cilium morphology (HP:0005938)	2.26950006
36	Abnormal respiratory epithelium morphology (HP:0012253)	2.26950006
37	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.24807547
38	Abnormal protein N-linked glycosylation (HP:0012347)	2.24807547
39	Abnormal protein glycosylation (HP:0012346)	2.24807547
40	Abnormal glycosylation (HP:0012345)	2.24807547
41	Cerebral edema (HP:0002181)	2.22998793
42	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.22024135
43	Medial flaring of the eyebrow (HP:0010747)	2.20690299
44	Lipid accumulation in hepatocytes (HP:0006561)	2.18524219
45	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.18319809
46	Abnormality of the renal cortex (HP:0011035)	2.16958369
47	Asplenia (HP:0001746)	2.16306975
48	Abnormal rod and cone electroretinograms (HP:0008323)	2.16221551
49	Panhypogammaglobulinemia (HP:0003139)	2.15476467
50	Abnormality of the labia minora (HP:0012880)	2.15143076
51	Lactic acidosis (HP:0003128)	2.13311589
52	Absent/shortened dynein arms (HP:0200106)	2.13154325
53	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.13154325
54	Hepatic necrosis (HP:0002605)	2.13153056
55	Abnormal biliary tract physiology (HP:0012439)	2.12270435
56	Bile duct proliferation (HP:0001408)	2.12270435
57	Hepatocellular necrosis (HP:0001404)	2.11843237
58	Abnormality of eosinophils (HP:0001879)	2.11320386
59	Abnormality of T cell physiology (HP:0011840)	2.09505409
60	Stomach cancer (HP:0012126)	2.07706926
61	Abnormality of DNA repair (HP:0003254)	2.05254051
62	Pancytopenia (HP:0001876)	2.04003663
63	Increased hepatocellular lipid droplets (HP:0006565)	2.02147683
64	Prostate neoplasm (HP:0100787)	2.01338388
65	Congenital hepatic fibrosis (HP:0002612)	2.00591850
66	Decreased central vision (HP:0007663)	2.00517896
67	Type II lissencephaly (HP:0007260)	1.98692014
68	Abnormality of the pons (HP:0007361)	1.98494330
69	3-Methylglutaconic aciduria (HP:0003535)	1.97439867
70	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.97410904
71	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.96871492
72	T lymphocytopenia (HP:0005403)	1.96503318
73	Chromsome breakage (HP:0040012)	1.92838566
74	Abnormality of B cell number (HP:0010975)	1.92713292
75	Aplasia/hypoplasia of the uterus (HP:0008684)	1.91875753
76	Lethargy (HP:0001254)	1.89756723
77	Concave nail (HP:0001598)	1.89505686
78	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.87917345
79	Dicarboxylic aciduria (HP:0003215)	1.87917345
80	Increased serum lactate (HP:0002151)	1.86999818
81	Attenuation of retinal blood vessels (HP:0007843)	1.86711179
82	Duplicated collecting system (HP:0000081)	1.85952906
83	Abnormality of the ileum (HP:0001549)	1.84611906
84	Abnormality of the renal collecting system (HP:0004742)	1.84397962
85	Meckel diverticulum (HP:0002245)	1.83514941
86	Abnormality of T cell number (HP:0011839)	1.81943356
87	Constricted visual fields (HP:0001133)	1.81838045
88	Abnormality of T cells (HP:0002843)	1.81829810
89	Retrobulbar optic neuritis (HP:0100654)	1.81405218
90	Optic neuritis (HP:0100653)	1.81405218
91	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.79736771
92	Pendular nystagmus (HP:0012043)	1.79725504
93	Sclerocornea (HP:0000647)	1.76589650
94	Abnormality of homocysteine metabolism (HP:0010919)	1.76357360
95	Homocystinuria (HP:0002156)	1.76357360
96	Cerebellar dysplasia (HP:0007033)	1.76157800
97	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.75750861
98	Myositis (HP:0100614)	1.75071833
99	Furrowed tongue (HP:0000221)	1.74668970
100	Hypoplasia of the pons (HP:0012110)	1.73249959

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.84615839
2	TAOK3	3.53615782
3	TLK1	3.51949698
4	STK16	3.28563236
5	TXK	3.03063270
6	VRK2	2.90880833
7	MAP4K2	2.38268158
8	MST4	2.10827676
9	VRK1	2.10320134
10	TEC	2.09969399
11	ADRBK2	2.08097578
12	FRK	2.02351130
13	BMPR1B	1.99130258
14	EIF2AK3	1.97576238
15	CDC7	1.87577108
16	PINK1	1.85698622
17	BCKDK	1.80488718
18	SRPK1	1.76707827
19	CSF1R	1.71429034
20	MAP3K12	1.70876324
21	ITK	1.57431129
22	EIF2AK2	1.56341687
23	PLK4	1.54751233
24	BUB1	1.44068055
25	MKNK1	1.44019446
26	IKBKB	1.39022291
27	PBK	1.29874260
28	GRK1	1.29378920
29	KIT	1.29206089
30	NUAK1	1.27579863
31	MAP3K14	1.25449220
32	PLK3	1.24945290
33	WNK4	1.21374779
34	CLK1	1.16283135
35	WNK3	1.15999523
36	TBK1	1.14069551
37	DYRK2	1.13221832
38	PHKG2	1.08164368
39	PHKG1	1.08164368
40	BTK	1.07787477
41	FES	1.07781876
42	IKBKE	1.07524787
43	SIK2	1.04611108
44	MAP2K2	1.03945119
45	DAPK2	1.02442025
46	IRAK1	1.02084889
47	TSSK6	1.01868216
48	GRK6	0.99845583
49	SYK	0.97850446
50	NEK2	0.93272536
51	MAP3K4	0.92729765
52	DAPK1	0.91271788
53	PDK2	0.90946514
54	RPS6KA5	0.85231498
55	MKNK2	0.84100563
56	MAP2K6	0.81283264
57	TIE1	0.79810914
58	CHUK	0.77289550
59	TRIM28	0.72960319
60	ADRBK1	0.68835305
61	PLK2	0.68805270
62	EPHA3	0.66422704
63	PASK	0.66162484
64	PRKCQ	0.64852658
65	WEE1	0.64267816
66	INSRR	0.61193911
67	IGF1R	0.59588085
68	CHEK2	0.59263829
69	AURKB	0.58197156
70	JAK1	0.57184626
71	MAPKAPK5	0.55860064
72	MAPK13	0.54581971
73	PTK2B	0.53534564
74	LCK	0.53287883
75	MATK	0.52879834
76	HCK	0.50914568
77	PLK1	0.50344244
78	EIF2AK1	0.49497312
79	NEK1	0.48099552
80	ATR	0.47534011
81	CSNK1G3	0.40797947
82	LYN	0.39041088
83	CSNK1G2	0.37656549
84	BRSK2	0.37483979
85	TNIK	0.36500031
86	CSNK1G1	0.35946744
87	PIK3CG	0.34384094
88	CSNK2A1	0.33442760
89	ABL1	0.33158064
90	CSNK1A1L	0.32842021
91	RPS6KA1	0.31746446
92	GRK7	0.31115618
93	NLK	0.28737733
94	ATM	0.28281269
95	STK38L	0.28249250
96	PRKCG	0.27771295
97	OXSR1	0.26974377
98	PRKCE	0.26779913
99	BMPR2	0.26115098
100	ALK	0.25902044

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.41002226
2	Protein export_Homo sapiens_hsa03060	2.70595703
3	RNA polymerase_Homo sapiens_hsa03020	2.63031892
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.54081304
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.44574057
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.39535870
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.24754131
8	Homologous recombination_Homo sapiens_hsa03440	2.17320071
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.09342469
10	Basal transcription factors_Homo sapiens_hsa03022	2.05406566
11	Ribosome_Homo sapiens_hsa03010	2.04876629
12	RNA degradation_Homo sapiens_hsa03018	2.00747908
13	Asthma_Homo sapiens_hsa05310	1.95834143
14	Phototransduction_Homo sapiens_hsa04744	1.87561789
15	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.87227623
16	Parkinsons disease_Homo sapiens_hsa05012	1.86597318
17	Non-homologous end-joining_Homo sapiens_hsa03450	1.84002400
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.73788376
19	One carbon pool by folate_Homo sapiens_hsa00670	1.73017858
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.65968915
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.62390997
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.59842321
23	Spliceosome_Homo sapiens_hsa03040	1.57498195
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.54685200
25	Peroxisome_Homo sapiens_hsa04146	1.52576873
26	Allograft rejection_Homo sapiens_hsa05330	1.43459320
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.42195700
28	Base excision repair_Homo sapiens_hsa03410	1.40276244
29	Mismatch repair_Homo sapiens_hsa03430	1.38548195
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.38334661
31	Propanoate metabolism_Homo sapiens_hsa00640	1.36845841
32	Graft-versus-host disease_Homo sapiens_hsa05332	1.36644523
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.36255826
34	DNA replication_Homo sapiens_hsa03030	1.35930729
35	Nucleotide excision repair_Homo sapiens_hsa03420	1.35424354
36	Sulfur metabolism_Homo sapiens_hsa00920	1.30894496
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30473189
38	Type I diabetes mellitus_Homo sapiens_hsa04940	1.29869110
39	RNA transport_Homo sapiens_hsa03013	1.29308786
40	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.28331271
41	Huntingtons disease_Homo sapiens_hsa05016	1.19399084
42	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.18028214
43	Purine metabolism_Homo sapiens_hsa00230	1.17881852
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.17397159
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.13420567
46	Butanoate metabolism_Homo sapiens_hsa00650	1.12737815
47	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.12580219
48	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.10652989
49	Alzheimers disease_Homo sapiens_hsa05010	1.10147219
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.08189021
51	Antigen processing and presentation_Homo sapiens_hsa04612	1.06180725
52	Tryptophan metabolism_Homo sapiens_hsa00380	1.03529630
53	Rheumatoid arthritis_Homo sapiens_hsa05323	1.03123912
54	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.01971610
55	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.00450048
56	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.00330234
57	Fatty acid elongation_Homo sapiens_hsa00062	0.99973314
58	Caffeine metabolism_Homo sapiens_hsa00232	0.96114281
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.95340438
60	Olfactory transduction_Homo sapiens_hsa04740	0.94545413
61	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.93465052
62	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.85432544
63	Retinol metabolism_Homo sapiens_hsa00830	0.81398591
64	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.80996817
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79643956
66	Nicotine addiction_Homo sapiens_hsa05033	0.78895132
67	Regulation of autophagy_Homo sapiens_hsa04140	0.69502611
68	Glutathione metabolism_Homo sapiens_hsa00480	0.66876577
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.64731518
70	Cardiac muscle contraction_Homo sapiens_hsa04260	0.62806100
71	Metabolic pathways_Homo sapiens_hsa01100	0.62663804
72	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.62626201
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61333148
74	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.60953661
75	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57839002
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.55227854
77	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.54926626
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53840682
79	Salivary secretion_Homo sapiens_hsa04970	0.51122776
80	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.50177921
81	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.47830500
82	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.46385710
83	Ether lipid metabolism_Homo sapiens_hsa00565	0.46059938
84	Fatty acid degradation_Homo sapiens_hsa00071	0.45748211
85	Steroid biosynthesis_Homo sapiens_hsa00100	0.44944509
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.44543673
87	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.42430831
88	Herpes simplex infection_Homo sapiens_hsa05168	0.42233245
89	Taste transduction_Homo sapiens_hsa04742	0.41772538
90	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41629800
91	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.41473102
92	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.40489827
93	Pyruvate metabolism_Homo sapiens_hsa00620	0.40419754
94	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.40383791
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39339890
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38778913
97	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.37608406
98	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.36954904
99	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.35660648
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.35519970

HNRNPA1P23

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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