HNRNPA1P25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.25546029
2establishment of protein localization to mitochondrial membrane (GO:0090151)7.23972697
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.54010133
4ATP synthesis coupled proton transport (GO:0015986)6.54010133
5cytidine deamination (GO:0009972)6.02162958
6cytidine metabolic process (GO:0046087)6.02162958
7cytidine catabolic process (GO:0006216)6.02162958
8ribosomal small subunit assembly (GO:0000028)5.87115647
9DNA deamination (GO:0045006)5.69908343
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.64408179
11viral transcription (GO:0019083)5.57882165
12translational termination (GO:0006415)5.37414201
13pyrimidine ribonucleoside catabolic process (GO:0046133)5.17747818
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.08345172
15cotranslational protein targeting to membrane (GO:0006613)5.02211755
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.01097210
17protein targeting to ER (GO:0045047)4.94861803
18translational elongation (GO:0006414)4.79294755
19respiratory electron transport chain (GO:0022904)4.77925639
20electron transport chain (GO:0022900)4.72256928
21establishment of protein localization to endoplasmic reticulum (GO:0072599)4.67917650
22maturation of SSU-rRNA (GO:0030490)4.64746153
23protein localization to endoplasmic reticulum (GO:0070972)4.61608322
24proteasome assembly (GO:0043248)4.37871501
25chaperone-mediated protein transport (GO:0072321)4.26665453
26response to pheromone (GO:0019236)4.23252152
27protein neddylation (GO:0045116)4.15551502
28cellular protein complex disassembly (GO:0043624)4.05300047
29viral life cycle (GO:0019058)4.04955001
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.98186600
31termination of RNA polymerase III transcription (GO:0006386)3.98186600
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.95659756
33tryptophan catabolic process (GO:0006569)3.90243734
34indole-containing compound catabolic process (GO:0042436)3.90243734
35indolalkylamine catabolic process (GO:0046218)3.90243734
36protein complex biogenesis (GO:0070271)3.89049382
37ribosomal large subunit biogenesis (GO:0042273)3.88687634
38sequestering of actin monomers (GO:0042989)3.77877713
39translation (GO:0006412)3.77680432
40inner mitochondrial membrane organization (GO:0007007)3.77389492
41water-soluble vitamin biosynthetic process (GO:0042364)3.73644264
42translational initiation (GO:0006413)3.67785552
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.67582841
44ribosomal small subunit biogenesis (GO:0042274)3.64858136
45intracellular protein transmembrane import (GO:0044743)3.63065651
46ATP biosynthetic process (GO:0006754)3.61559701
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.56008527
48mitochondrial respiratory chain complex assembly (GO:0033108)3.55954220
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.44406509
50regulation of chronic inflammatory response (GO:0002676)3.40771172
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.35213306
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.33389250
53mitochondrial respiratory chain complex I assembly (GO:0032981)3.33389250
54NADH dehydrogenase complex assembly (GO:0010257)3.33389250
55regulation of cellular amino acid metabolic process (GO:0006521)3.33385428
56signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.31774451
57signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.31774451
58signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.31774451
59hydrogen ion transmembrane transport (GO:1902600)3.30490791
60intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.25913108
61signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.25913108
62protein targeting to membrane (GO:0006612)3.24875531
63protein complex disassembly (GO:0043241)3.24865384
64purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.20671255
65oxidative phosphorylation (GO:0006119)3.19961793
66purine nucleoside triphosphate biosynthetic process (GO:0009145)3.19708397
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18176508
68signal transduction involved in DNA integrity checkpoint (GO:0072401)3.16386634
69signal transduction involved in DNA damage checkpoint (GO:0072422)3.16386634
70signal transduction involved in cell cycle checkpoint (GO:0072395)3.13846765
71macromolecular complex disassembly (GO:0032984)3.11448680
72proton transport (GO:0015992)3.07331132
73kynurenine metabolic process (GO:0070189)3.06984605
74negative regulation of ligase activity (GO:0051352)3.06246326
75negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.06246326
76spliceosomal complex assembly (GO:0000245)3.05134885
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.04259577
78nuclear-transcribed mRNA catabolic process (GO:0000956)3.02661783
79tryptophan metabolic process (GO:0006568)3.00698461
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99880248
81indolalkylamine metabolic process (GO:0006586)2.98963174
82hydrogen transport (GO:0006818)2.98672948
83cytochrome complex assembly (GO:0017004)2.95802122
84RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.93508164
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.93508164
86behavioral response to nicotine (GO:0035095)2.92351638
87protein-cofactor linkage (GO:0018065)2.92289742
88spliceosomal snRNP assembly (GO:0000387)2.91038123
89production of molecular mediator involved in inflammatory response (GO:0002532)2.89920506
90cell wall macromolecule metabolic process (GO:0044036)2.88813692
91mRNA catabolic process (GO:0006402)2.85723136
92intracellular protein transmembrane transport (GO:0065002)2.85372419
93iron-sulfur cluster assembly (GO:0016226)2.84072598
94metallo-sulfur cluster assembly (GO:0031163)2.84072598
95antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.83194435
96respiratory chain complex IV assembly (GO:0008535)2.80250439
97cytolysis (GO:0019835)2.76068106
98ribonucleoside triphosphate biosynthetic process (GO:0009201)2.71165848
99RNA catabolic process (GO:0006401)2.70661379
100anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70585125

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.48138548
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.20274903
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.07705883
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.94502957
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.81750401
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.18835800
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.91051428
8CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.86586867
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85953325
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.67661075
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.61000232
12VDR_22108803_ChIP-Seq_LS180_Human2.52981741
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.45546603
14VDR_23849224_ChIP-Seq_CD4+_Human2.44952460
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37670903
16ELK1_19687146_ChIP-ChIP_HELA_Human2.16044283
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14958786
18FOXP3_21729870_ChIP-Seq_TREG_Human2.09170294
19TAF15_26573619_Chip-Seq_HEK293_Human2.07642936
20MYC_18940864_ChIP-ChIP_HL60_Human2.06408879
21ZNF274_21170338_ChIP-Seq_K562_Hela2.04428138
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84142077
23EWS_26573619_Chip-Seq_HEK293_Human1.83732496
24IGF1R_20145208_ChIP-Seq_DFB_Human1.81571051
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80310339
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72007945
27TTF2_22483619_ChIP-Seq_HELA_Human1.65992678
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63689358
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60739935
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.60400727
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.58474009
32POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.56345325
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54355257
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.54293288
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.52864870
36FUS_26573619_Chip-Seq_HEK293_Human1.52730001
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50809039
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48662653
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44912177
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41215734
41TP53_22573176_ChIP-Seq_HFKS_Human1.39629834
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.39091782
43XRN2_22483619_ChIP-Seq_HELA_Human1.34856941
44ELK1_22589737_ChIP-Seq_MCF10A_Human1.31682579
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31374672
46DCP1A_22483619_ChIP-Seq_HELA_Human1.28330987
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27117209
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25914640
49AR_20517297_ChIP-Seq_VCAP_Human1.25578941
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.25223790
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25090110
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24573532
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24419601
54AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24105327
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23318751
56ER_23166858_ChIP-Seq_MCF-7_Human1.23054289
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22909330
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20083621
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.19926343
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18049989
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17934061
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15979158
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14830059
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14064512
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14056452
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13851461
67HTT_18923047_ChIP-ChIP_STHdh_Human1.12671806
68ERG_20517297_ChIP-Seq_VCAP_Human1.12052986
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10765733
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09821669
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07834198
72CBP_20019798_ChIP-Seq_JUKART_Human1.07834198
73PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07580561
74GATA3_26560356_Chip-Seq_TH2_Human1.06433104
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06221146
76P300_19829295_ChIP-Seq_ESCs_Human1.05601516
77GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05356641
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05327970
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05199250
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03933731
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02498619
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.02498619
83NCOR_22424771_ChIP-Seq_293T_Human1.02052490
84TAF2_19829295_ChIP-Seq_ESCs_Human1.01965802
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00499737
86SOX2_19829295_ChIP-Seq_ESCs_Human0.99731299
87NANOG_19829295_ChIP-Seq_ESCs_Human0.99731299
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98190053
89FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97871060
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.97350417
91E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95370512
92ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95199904
93GATA6_21074721_ChIP-Seq_CACO-2_Human0.95003717
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93999908
95CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92469273
96FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.91883349
97RBPJ_21746931_ChIP-Seq_IB4_Human0.90999142
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89935438
99GABP_19822575_ChIP-Seq_HepG2_Human0.89531487
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.86505956

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.43709734
2MP0006292_abnormal_olfactory_placode4.35083041
3MP0005671_abnormal_response_to3.74586968
4MP0003878_abnormal_ear_physiology2.59673653
5MP0005377_hearing/vestibular/ear_phenot2.59673653
6MP0008875_abnormal_xenobiotic_pharmacok2.49565058
7MP0005084_abnormal_gallbladder_morpholo2.46101988
8MP0009785_altered_susceptibility_to2.22901585
9MP0008058_abnormal_DNA_repair2.16857784
10MP0003136_yellow_coat_color2.08960578
11MP0008872_abnormal_physiological_respon2.06391837
12MP0002102_abnormal_ear_morphology2.04563761
13MP0003880_abnormal_central_pattern1.91881661
14MP0001873_stomach_inflammation1.87965604
15MP0001485_abnormal_pinna_reflex1.86605516
16MP0006082_CNS_inflammation1.83783520
17MP0006072_abnormal_retinal_apoptosis1.83237927
18MP0001835_abnormal_antigen_presentation1.79967884
19MP0009333_abnormal_splenocyte_physiolog1.75934754
20MP0003567_abnormal_fetal_cardiomyocyte1.68547445
21MP0004142_abnormal_muscle_tone1.62523292
22MP0005645_abnormal_hypothalamus_physiol1.62087577
23MP0002095_abnormal_skin_pigmentation1.55278224
24MP0003763_abnormal_thymus_physiology1.54045568
25MP0008877_abnormal_DNA_methylation1.52363255
26MP0002938_white_spotting1.52358360
27MP0005551_abnormal_eye_electrophysiolog1.51117108
28MP0002148_abnormal_hypersensitivity_rea1.49980323
29MP0003950_abnormal_plasma_membrane1.48134684
30MP0002736_abnormal_nociception_after1.45017672
31MP0003866_abnormal_defecation1.44892380
32MP0004145_abnormal_muscle_electrophysio1.42994531
33MP0002277_abnormal_respiratory_mucosa1.40430170
34MP0004885_abnormal_endolymph1.38772672
35MP0005646_abnormal_pituitary_gland1.37510867
36MP0000685_abnormal_immune_system1.35300172
37MP0002638_abnormal_pupillary_reflex1.35110646
38MP0002138_abnormal_hepatobiliary_system1.34211789
39MP0001800_abnormal_humoral_immune1.33400270
40MP0004133_heterotaxia1.31281957
41MP0000372_irregular_coat_pigmentation1.28798238
42MP0005253_abnormal_eye_physiology1.27299382
43MP0005410_abnormal_fertilization1.26679933
44MP0001905_abnormal_dopamine_level1.22837167
45MP0003011_delayed_dark_adaptation1.19968936
46MP0008995_early_reproductive_senescence1.19817269
47MP0006035_abnormal_mitochondrial_morpho1.19387396
48MP0002234_abnormal_pharynx_morphology1.17126333
49MP0005000_abnormal_immune_tolerance1.16797712
50MP0002876_abnormal_thyroid_physiology1.16675570
51MP0001968_abnormal_touch/_nociception1.15457638
52MP0003195_calcinosis1.14970272
53MP0005387_immune_system_phenotype1.12941026
54MP0001790_abnormal_immune_system1.12941026
55MP0006036_abnormal_mitochondrial_physio1.12785645
56MP0001348_abnormal_lacrimal_gland1.12609659
57MP0010030_abnormal_orbit_morphology1.09909710
58MP0002160_abnormal_reproductive_system1.08917749
59MP0002006_tumorigenesis1.07262466
60MP0002723_abnormal_immune_serum1.03560844
61MP0002166_altered_tumor_susceptibility1.03022226
62MP0003786_premature_aging1.02652514
63MP0002420_abnormal_adaptive_immunity1.02520708
64MP0001764_abnormal_homeostasis1.01412881
65MP0001819_abnormal_immune_cell1.00193294
66MP0000049_abnormal_middle_ear0.99302951
67MP0002837_dystrophic_cardiac_calcinosis0.98158622
68MP0000631_abnormal_neuroendocrine_gland0.97766269
69MP0001293_anophthalmia0.96642315
70MP0005025_abnormal_response_to0.96333362
71MP0003938_abnormal_ear_development0.96220450
72MP0003137_abnormal_impulse_conducting0.92574645
73MP0008789_abnormal_olfactory_epithelium0.91019065
74MP0001919_abnormal_reproductive_system0.89976625
75MP0001529_abnormal_vocalization0.89599961
76MP0003186_abnormal_redox_activity0.87773989
77MP0000716_abnormal_immune_system0.86691678
78MP0005389_reproductive_system_phenotype0.86463291
79MP0001486_abnormal_startle_reflex0.85340184
80MP0004957_abnormal_blastocyst_morpholog0.84958249
81MP0002396_abnormal_hematopoietic_system0.84829584
82MP0001346_abnormal_lacrimal_gland0.84438841
83MP0005195_abnormal_posterior_eye0.83551309
84MP0001666_abnormal_nutrient_absorption0.81933129
85MP0005085_abnormal_gallbladder_physiolo0.80352402
86MP0005075_abnormal_melanosome_morpholog0.79932038
87MP0010155_abnormal_intestine_physiology0.79268384
88MP0003283_abnormal_digestive_organ0.78940869
89MP0010094_abnormal_chromosome_stability0.78690309
90MP0002405_respiratory_system_inflammati0.77878840
91MP0000703_abnormal_thymus_morphology0.77789269
92MP0003936_abnormal_reproductive_system0.76812209
93MP0002452_abnormal_antigen_presenting0.75928595
94MP0002398_abnormal_bone_marrow0.75632568
95MP0009745_abnormal_behavioral_response0.74965971
96MP0001845_abnormal_inflammatory_respons0.74749250
97MP0001502_abnormal_circadian_rhythm0.73812140
98MP0001663_abnormal_digestive_system0.71635200
99MP0000026_abnormal_inner_ear0.68433125
100MP0006276_abnormal_autonomic_nervous0.66826761

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.65108224
2Mitochondrial inheritance (HP:0001427)4.30036111
3Abnormal mitochondria in muscle tissue (HP:0008316)4.03009355
4Aplastic anemia (HP:0001915)3.94532996
5Hepatocellular necrosis (HP:0001404)3.85141620
6Acute encephalopathy (HP:0006846)3.80367020
7Progressive macrocephaly (HP:0004481)3.76638645
83-Methylglutaconic aciduria (HP:0003535)3.71214493
9Increased CSF lactate (HP:0002490)3.68297942
10Pancreatic cysts (HP:0001737)3.66338728
11Reticulocytopenia (HP:0001896)3.64757556
12Autoimmune thrombocytopenia (HP:0001973)3.63169526
13True hermaphroditism (HP:0010459)3.59310878
14Autoimmune hemolytic anemia (HP:0001890)3.37419871
15Colon cancer (HP:0003003)3.36871292
16Hepatic necrosis (HP:0002605)3.36182984
17Abnormality of B cell number (HP:0010975)3.25177014
18Increased hepatocellular lipid droplets (HP:0006565)3.25018947
19Macrocytic anemia (HP:0001972)3.09188742
20Pancreatic fibrosis (HP:0100732)3.00419052
21Methylmalonic acidemia (HP:0002912)2.96616552
22Cerebral edema (HP:0002181)2.93651933
23Lipid accumulation in hepatocytes (HP:0006561)2.90356325
24Congenital, generalized hypertrichosis (HP:0004540)2.75556192
25Congenital stationary night blindness (HP:0007642)2.74071319
26Optic disc pallor (HP:0000543)2.71155600
27Stomach cancer (HP:0012126)2.60788576
28Pendular nystagmus (HP:0012043)2.57008226
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.55860071
30Aplasia/Hypoplasia of the sacrum (HP:0008517)2.55046270
31Sclerocornea (HP:0000647)2.52214974
32Abnormal number of erythroid precursors (HP:0012131)2.50784594
33Methylmalonic aciduria (HP:0012120)2.47847367
34Abnormality of cells of the erythroid lineage (HP:0012130)2.47504272
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.44735282
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.44735282
37Respiratory failure (HP:0002878)2.44688276
38Renal Fanconi syndrome (HP:0001994)2.44470879
39Abnormality of midbrain morphology (HP:0002418)2.42611251
40Molar tooth sign on MRI (HP:0002419)2.42611251
41Pallor (HP:0000980)2.40637036
42Increased serum lactate (HP:0002151)2.37385079
43Increased IgM level (HP:0003496)2.37061171
44Bile duct proliferation (HP:0001408)2.32948038
45Abnormal biliary tract physiology (HP:0012439)2.32948038
46Leukodystrophy (HP:0002415)2.32182948
47Hypoproteinemia (HP:0003075)2.31762888
48Septo-optic dysplasia (HP:0100842)2.30877839
49Abnormality of T cell number (HP:0011839)2.28415291
50Abnormal rod and cone electroretinograms (HP:0008323)2.25231679
51Oral leukoplakia (HP:0002745)2.24487944
52Lactic acidosis (HP:0003128)2.19448831
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.17098726
54Pancytopenia (HP:0001876)2.16458024
55Nephronophthisis (HP:0000090)2.14713995
56Medial flaring of the eyebrow (HP:0010747)2.13518224
57Abolished electroretinogram (ERG) (HP:0000550)2.13467873
58B lymphocytopenia (HP:0010976)2.09169535
59Attenuation of retinal blood vessels (HP:0007843)2.07698168
60IgG deficiency (HP:0004315)2.07584934
61Megaloblastic anemia (HP:0001889)2.01751531
62Aplasia/hypoplasia of the uterus (HP:0008684)1.99030238
63Exertional dyspnea (HP:0002875)1.98874554
64Abnormality of the phalanges of the 2nd finger (HP:0009541)1.98546477
65Severe combined immunodeficiency (HP:0004430)1.98148626
66Fibular aplasia (HP:0002990)1.98018026
67Abnormality of T cells (HP:0002843)1.97277617
68Lethargy (HP:0001254)1.95079812
69Central scotoma (HP:0000603)1.94990728
70Aplasia/Hypoplasia of the ulna (HP:0006495)1.93965479
71Abnormality of the vitamin B12 metabolism (HP:0004341)1.93687500
72Abnormal delayed hypersensitivity skin test (HP:0002963)1.92366830
73Abnormality of the ileum (HP:0001549)1.92287796
74Meckel diverticulum (HP:0002245)1.91401513
75Dyschromatopsia (HP:0007641)1.90737079
76Cellular immunodeficiency (HP:0005374)1.89808082
77Abnormal number of incisors (HP:0011064)1.88803421
78Hypokalemic alkalosis (HP:0001949)1.88757904
79Abnormality of the renal cortex (HP:0011035)1.87520389
80Male pseudohermaphroditism (HP:0000037)1.85954120
81Postaxial foot polydactyly (HP:0001830)1.85885811
82Testicular atrophy (HP:0000029)1.84214488
83Absent thumb (HP:0009777)1.83355927
84Cystic liver disease (HP:0006706)1.82907169
85Anencephaly (HP:0002323)1.82607014
86Triphalangeal thumb (HP:0001199)1.82218190
87Maternal diabetes (HP:0009800)1.82196356
88T lymphocytopenia (HP:0005403)1.81458396
89Constricted visual fields (HP:0001133)1.81362919
90Abnormality of vitamin B metabolism (HP:0004340)1.80868999
91Abnormality of the pons (HP:0007361)1.80335628
92Hypoalbuminemia (HP:0003073)1.79827849
93Abnormal albumin level (HP:0012116)1.79827849
94Increased intramyocellular lipid droplets (HP:0012240)1.79593117
95Hypoplasia of the ulna (HP:0003022)1.79127796
96Abnormality of the prostate (HP:0008775)1.78011144
97Stenosis of the external auditory canal (HP:0000402)1.76253672
98Renal cortical cysts (HP:0000803)1.75823692
99Abnormality of eosinophils (HP:0001879)1.73927183
100Abnormality of renal resorption (HP:0011038)1.73215907

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.04095530
2ZAK3.72919927
3PASK3.72314810
4TXK3.03876714
5PNCK2.61526334
6VRK12.51850652
7KDR2.28801212
8BUB12.28466308
9ADRBK22.28408638
10NEK12.20903085
11MAP4K12.19631444
12MAP4K22.19271910
13MST42.18737306
14EPHA42.15153633
15TLK12.06283303
16WEE11.87060281
17STK161.83454394
18NME11.80236992
19EIF2AK31.78425286
20WNK41.72094872
21SRPK11.72058246
22TAF11.67465912
23GRK11.62759431
24TRIM281.60439207
25TSSK61.58820023
26BCKDK1.57252595
27PINK11.47097421
28PLK31.46488325
29ITK1.42904375
30NUAK11.35966874
31BRSK21.31091680
32INSRR1.28084475
33PBK1.12932547
34MAPKAPK31.11100447
35PIK3CA1.09212115
36MAP3K111.04237741
37DYRK21.02454857
38MKNK11.02371509
39MAPK151.02247359
40MAP3K121.01895311
41WNK31.00277651
42TESK20.99654760
43FRK0.97410282
44CDC70.91186008
45PRKCQ0.89645490
46EIF2AK20.87193243
47TEC0.84486059
48EIF2AK10.83393295
49CHEK20.79982933
50TIE10.76318425
51SYK0.75847500
52ADRBK10.73063329
53IKBKE0.72021399
54FES0.68068303
55NTRK30.67562820
56LYN0.66874409
57MARK30.66151415
58CAMKK20.64684004
59LCK0.61130985
60JAK30.60430168
61STK38L0.60360896
62CDK190.60062436
63ATR0.59897890
64PRKCG0.58101467
65MAPKAPK50.57171732
66TGFBR10.57048275
67CSNK2A10.56176524
68GRK60.53581955
69GRK70.52148501
70IKBKB0.51276264
71CAMKK10.51031440
72CSNK2A20.48915052
73RPS6KB10.48236663
74OBSCN0.47387596
75OXSR10.46990289
76AURKB0.45840251
77DAPK10.45649457
78DAPK20.44845255
79BTK0.44541653
80RPS6KA50.43954756
81PIK3CG0.43255402
82PLK10.43103237
83MAP2K70.42044991
84PLK20.39974096
85PRKCA0.39692381
86DAPK30.39272688
87PRKACA0.38358006
88BRSK10.37454186
89MATK0.36852144
90MYLK0.36208364
91TYRO30.36034673
92BMPR1B0.35695664
93RPS6KA40.35639708
94RPS6KB20.34912203
95FGFR10.34566881
96IGF1R0.34188070
97CSNK1A10.33114312
98PRKCI0.32541003
99PIM10.32528505
100MAP3K50.31483201

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.87711731
2Proteasome_Homo sapiens_hsa030504.50026786
3Oxidative phosphorylation_Homo sapiens_hsa001904.27592388
4Parkinsons disease_Homo sapiens_hsa050123.57165432
5RNA polymerase_Homo sapiens_hsa030202.80147160
6Protein export_Homo sapiens_hsa030602.77491677
7Caffeine metabolism_Homo sapiens_hsa002322.64088908
8Huntingtons disease_Homo sapiens_hsa050162.41841858
9Alzheimers disease_Homo sapiens_hsa050102.28804644
10Primary immunodeficiency_Homo sapiens_hsa053402.24524826
11Homologous recombination_Homo sapiens_hsa034402.16462583
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.10422228
13Allograft rejection_Homo sapiens_hsa053301.97476872
14Mismatch repair_Homo sapiens_hsa034301.87674429
15Autoimmune thyroid disease_Homo sapiens_hsa053201.86748238
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85264219
17Cardiac muscle contraction_Homo sapiens_hsa042601.78694696
18Asthma_Homo sapiens_hsa053101.77936880
19Spliceosome_Homo sapiens_hsa030401.77665033
20Graft-versus-host disease_Homo sapiens_hsa053321.77513764
21Antigen processing and presentation_Homo sapiens_hsa046121.70087719
22DNA replication_Homo sapiens_hsa030301.63507729
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59272709
24Type I diabetes mellitus_Homo sapiens_hsa049401.49252413
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.42026289
26Nitrogen metabolism_Homo sapiens_hsa009101.37596808
27RNA degradation_Homo sapiens_hsa030181.35126435
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34506067
29Phototransduction_Homo sapiens_hsa047441.29713626
30Pyrimidine metabolism_Homo sapiens_hsa002401.27640980
31Fanconi anemia pathway_Homo sapiens_hsa034601.24501692
32Hematopoietic cell lineage_Homo sapiens_hsa046401.21382113
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14153140
34Tryptophan metabolism_Homo sapiens_hsa003801.11793733
35Nucleotide excision repair_Homo sapiens_hsa034201.08005801
36Purine metabolism_Homo sapiens_hsa002301.07349872
37Linoleic acid metabolism_Homo sapiens_hsa005911.04322964
38RNA transport_Homo sapiens_hsa030131.03832653
39Rheumatoid arthritis_Homo sapiens_hsa053231.01904867
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99633643
41Base excision repair_Homo sapiens_hsa034100.92110478
42One carbon pool by folate_Homo sapiens_hsa006700.88660458
43Propanoate metabolism_Homo sapiens_hsa006400.87810092
44Primary bile acid biosynthesis_Homo sapiens_hsa001200.85746688
45Maturity onset diabetes of the young_Homo sapiens_hsa049500.84723751
46Basal transcription factors_Homo sapiens_hsa030220.83144282
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78835136
48Ether lipid metabolism_Homo sapiens_hsa005650.77898323
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75777216
50Non-homologous end-joining_Homo sapiens_hsa034500.74480517
51Butanoate metabolism_Homo sapiens_hsa006500.71594661
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70507122
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69044848
54Systemic lupus erythematosus_Homo sapiens_hsa053220.67403607
55Peroxisome_Homo sapiens_hsa041460.65910458
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64297717
57Olfactory transduction_Homo sapiens_hsa047400.63154641
58Metabolic pathways_Homo sapiens_hsa011000.60606548
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57492353
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56547370
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52772335
62T cell receptor signaling pathway_Homo sapiens_hsa046600.51689468
63Chemical carcinogenesis_Homo sapiens_hsa052040.51180026
64Collecting duct acid secretion_Homo sapiens_hsa049660.50705165
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50651715
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.50300827
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48587482
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47144908
69Regulation of autophagy_Homo sapiens_hsa041400.44920878
70Measles_Homo sapiens_hsa051620.42637364
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.41721566
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41683448
73Retinol metabolism_Homo sapiens_hsa008300.40982659
74Taste transduction_Homo sapiens_hsa047420.40347882
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39990475
76Vitamin digestion and absorption_Homo sapiens_hsa049770.39343266
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.37313372
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37055130
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36583966
80Epstein-Barr virus infection_Homo sapiens_hsa051690.35223891
81Arachidonic acid metabolism_Homo sapiens_hsa005900.32355043
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31243378
83Fat digestion and absorption_Homo sapiens_hsa049750.30929117
84Selenocompound metabolism_Homo sapiens_hsa004500.30494317
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30013371
86beta-Alanine metabolism_Homo sapiens_hsa004100.29097912
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.27948434
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26164041
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25877586
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23110109
91Glutathione metabolism_Homo sapiens_hsa004800.22872679
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22445641
93Mineral absorption_Homo sapiens_hsa049780.22301865
94Morphine addiction_Homo sapiens_hsa050320.22027984
95Viral myocarditis_Homo sapiens_hsa054160.21610559
96Nicotine addiction_Homo sapiens_hsa050330.18977498
97Malaria_Homo sapiens_hsa051440.16324324
98mRNA surveillance pathway_Homo sapiens_hsa030150.15149281
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14206038
100Pyruvate metabolism_Homo sapiens_hsa006200.13813101

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