

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | rRNA modification (GO:0000154) | 5.02511314 |
| 2 | ATP synthesis coupled proton transport (GO:0015986) | 4.89081188 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.89081188 |
| 4 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.86674359 |
| 5 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.83373706 |
| 6 | IMP biosynthetic process (GO:0006188) | 4.70357902 |
| 7 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 4.39554561 |
| 8 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 4.39215602 |
| 9 | DNA deamination (GO:0045006) | 4.35504717 |
| 10 | rRNA methylation (GO:0031167) | 4.34687255 |
| 11 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.23463944 |
| 12 | proteasome assembly (GO:0043248) | 4.19975302 |
| 13 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.02813501 |
| 14 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.99718929 |
| 15 | chaperone-mediated protein transport (GO:0072321) | 3.99148179 |
| 16 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.96441277 |
| 17 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.94827064 |
| 18 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.94453366 |
| 19 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.94453366 |
| 20 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.94453366 |
| 21 | IMP metabolic process (GO:0046040) | 3.92875204 |
| 22 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.85703359 |
| 23 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.85703359 |
| 24 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.84343715 |
| 25 | ribosome assembly (GO:0042255) | 3.81726252 |
| 26 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.81549688 |
| 27 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.80978998 |
| 28 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.80978998 |
| 29 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.79495250 |
| 30 | cullin deneddylation (GO:0010388) | 3.79289034 |
| 31 | ribosomal large subunit biogenesis (GO:0042273) | 3.78734864 |
| 32 | negative regulation of ligase activity (GO:0051352) | 3.77581299 |
| 33 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.77581299 |
| 34 | establishment of integrated proviral latency (GO:0075713) | 3.72744219 |
| 35 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.71712084 |
| 36 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.67262710 |
| 37 | pseudouridine synthesis (GO:0001522) | 3.64638977 |
| 38 | inner mitochondrial membrane organization (GO:0007007) | 3.63387896 |
| 39 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.57776908 |
| 40 | protein deneddylation (GO:0000338) | 3.57537712 |
| 41 | DNA damage response, detection of DNA damage (GO:0042769) | 3.47233076 |
| 42 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.46595348 |
| 43 | DNA strand elongation (GO:0022616) | 3.46165029 |
| 44 | DNA double-strand break processing (GO:0000729) | 3.44057038 |
| 45 | GTP biosynthetic process (GO:0006183) | 3.37907554 |
| 46 | purine nucleobase biosynthetic process (GO:0009113) | 3.32767469 |
| 47 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.30691569 |
| 48 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.24181896 |
| 49 | positive regulation of ligase activity (GO:0051351) | 3.24085838 |
| 50 | tRNA aminoacylation for protein translation (GO:0006418) | 3.24005856 |
| 51 | spliceosomal snRNP assembly (GO:0000387) | 3.21033024 |
| 52 | tRNA processing (GO:0008033) | 3.20263443 |
| 53 | amino acid activation (GO:0043038) | 3.19905420 |
| 54 | tRNA aminoacylation (GO:0043039) | 3.19905420 |
| 55 | respiratory chain complex IV assembly (GO:0008535) | 3.19372256 |
| 56 | protein neddylation (GO:0045116) | 3.17818125 |
| 57 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.13469607 |
| 58 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.11342878 |
| 59 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.11342878 |
| 60 | establishment of viral latency (GO:0019043) | 3.10695749 |
| 61 | tRNA metabolic process (GO:0006399) | 3.09089530 |
| 62 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.07866548 |
| 63 | nucleobase biosynthetic process (GO:0046112) | 3.06412327 |
| 64 | termination of RNA polymerase I transcription (GO:0006363) | 3.04918857 |
| 65 | ribosomal small subunit assembly (GO:0000028) | 3.03717073 |
| 66 | 7-methylguanosine mRNA capping (GO:0006370) | 3.01842020 |
| 67 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.01305736 |
| 68 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.00624800 |
| 69 | termination of RNA polymerase III transcription (GO:0006386) | 3.00624800 |
| 70 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.00103523 |
| 71 | tRNA modification (GO:0006400) | 2.99704310 |
| 72 | UTP biosynthetic process (GO:0006228) | 2.99492569 |
| 73 | chromatin remodeling at centromere (GO:0031055) | 2.98225699 |
| 74 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.97715288 |
| 75 | maturation of SSU-rRNA (GO:0030490) | 2.96787218 |
| 76 | rRNA processing (GO:0006364) | 2.96504023 |
| 77 | GMP metabolic process (GO:0046037) | 2.93844554 |
| 78 | RNA capping (GO:0036260) | 2.93795605 |
| 79 | 7-methylguanosine RNA capping (GO:0009452) | 2.93795605 |
| 80 | CTP biosynthetic process (GO:0006241) | 2.93372982 |
| 81 | CTP metabolic process (GO:0046036) | 2.93372982 |
| 82 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.93215168 |
| 83 | purine-containing compound salvage (GO:0043101) | 2.93070821 |
| 84 | positive regulation of cell cycle arrest (GO:0071158) | 2.92985733 |
| 85 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.91852788 |
| 86 | telomere maintenance via telomere lengthening (GO:0010833) | 2.89775733 |
| 87 | protein K6-linked ubiquitination (GO:0085020) | 2.89074241 |
| 88 | behavioral response to nicotine (GO:0035095) | 2.88341762 |
| 89 | regulation of cellular amine metabolic process (GO:0033238) | 2.87142967 |
| 90 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.86718565 |
| 91 | rRNA metabolic process (GO:0016072) | 2.86234999 |
| 92 | replication fork processing (GO:0031297) | 2.86037922 |
| 93 | ATP biosynthetic process (GO:0006754) | 2.85022994 |
| 94 | translation (GO:0006412) | 2.84616417 |
| 95 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.84136628 |
| 96 | UTP metabolic process (GO:0046051) | 2.83982018 |
| 97 | DNA demethylation (GO:0080111) | 2.83939255 |
| 98 | protein complex biogenesis (GO:0070271) | 2.83572335 |
| 99 | regulation of ligase activity (GO:0051340) | 2.83155420 |
| 100 | negative regulation of protein ubiquitination (GO:0031397) | 2.82140630 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.81587283 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.74508234 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.59309574 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.09168735 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.49933769 |
| 6 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.32326526 |
| 7 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.30953294 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.29104706 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.23449103 |
| 10 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.17295661 |
| 11 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.08161798 |
| 12 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.94948579 |
| 13 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.94788344 |
| 14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.90858253 |
| 15 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.79789588 |
| 16 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.79406740 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.78572531 |
| 18 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.73395214 |
| 19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.50038537 |
| 20 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.39919662 |
| 21 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.26248017 |
| 22 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.26175863 |
| 23 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.19788299 |
| 24 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.10727240 |
| 25 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.09758892 |
| 26 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.07324982 |
| 27 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.06757841 |
| 28 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.04936055 |
| 29 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.04678596 |
| 30 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.98122579 |
| 31 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.94061012 |
| 32 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.93553883 |
| 33 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.90159936 |
| 34 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.87938418 |
| 35 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.85933458 |
| 36 | VDR_22108803_ChIP-Seq_LS180_Human | 1.85565440 |
| 37 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.85326665 |
| 38 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.79907568 |
| 39 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.78479961 |
| 40 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.75447023 |
| 41 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.75147622 |
| 42 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.66611718 |
| 43 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.66511879 |
| 44 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.66031603 |
| 45 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.63470004 |
| 46 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.62589451 |
| 47 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.56356188 |
| 48 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.51312050 |
| 49 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.47033018 |
| 50 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.46682532 |
| 51 | EWS_26573619_Chip-Seq_HEK293_Human | 1.44996335 |
| 52 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.44994264 |
| 53 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.44280495 |
| 54 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.33221226 |
| 55 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.33142667 |
| 56 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.27554881 |
| 57 | FUS_26573619_Chip-Seq_HEK293_Human | 1.23571945 |
| 58 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.21963207 |
| 59 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.15044683 |
| 60 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.14380068 |
| 61 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.14215456 |
| 62 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.14120914 |
| 63 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.14083953 |
| 64 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.13523288 |
| 65 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.13334084 |
| 66 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.10072607 |
| 67 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.09084929 |
| 68 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.08836689 |
| 69 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.07991686 |
| 70 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.07976345 |
| 71 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.02275945 |
| 72 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.02202717 |
| 73 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.97264442 |
| 74 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.95144095 |
| 75 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.91300138 |
| 76 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.91101030 |
| 77 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.91026030 |
| 78 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.90279401 |
| 79 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.89836224 |
| 80 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.88527869 |
| 81 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.88180662 |
| 82 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.85688077 |
| 83 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 0.83942799 |
| 84 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.82809052 |
| 85 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.82756289 |
| 86 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.81480303 |
| 87 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.81480303 |
| 88 | P300_19829295_ChIP-Seq_ESCs_Human | 0.81169138 |
| 89 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.80494683 |
| 90 | AR_20517297_ChIP-Seq_VCAP_Human | 0.80355865 |
| 91 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.80001665 |
| 92 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.78522558 |
| 93 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.77915497 |
| 94 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.77090433 |
| 95 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.76995853 |
| 96 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.74928555 |
| 97 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.74120697 |
| 98 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.73755312 |
| 99 | NCOR_22424771_ChIP-Seq_293T_Human | 0.73112544 |
| 100 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.72847832 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 4.57411833 |
| 2 | MP0002102_abnormal_ear_morphology | 3.75705544 |
| 3 | MP0010094_abnormal_chromosome_stability | 3.70644046 |
| 4 | MP0008877_abnormal_DNA_methylation | 3.57832008 |
| 5 | MP0003693_abnormal_embryo_hatching | 3.51980695 |
| 6 | MP0006292_abnormal_olfactory_placode | 3.34827402 |
| 7 | MP0002254_reproductive_system_inflammat | 2.95180406 |
| 8 | MP0003111_abnormal_nucleus_morphology | 2.88514650 |
| 9 | MP0004147_increased_porphyrin_level | 2.76736528 |
| 10 | MP0004957_abnormal_blastocyst_morpholog | 2.72369006 |
| 11 | MP0003786_premature_aging | 2.33316903 |
| 12 | MP0008789_abnormal_olfactory_epithelium | 2.27579085 |
| 13 | MP0008057_abnormal_DNA_replication | 2.19299116 |
| 14 | MP0005394_taste/olfaction_phenotype | 2.09889392 |
| 15 | MP0005499_abnormal_olfactory_system | 2.09889392 |
| 16 | MP0006072_abnormal_retinal_apoptosis | 2.07579488 |
| 17 | MP0005084_abnormal_gallbladder_morpholo | 2.07286917 |
| 18 | MP0003718_maternal_effect | 2.06298979 |
| 19 | MP0003077_abnormal_cell_cycle | 1.98068878 |
| 20 | MP0005671_abnormal_response_to | 1.83884854 |
| 21 | MP0002736_abnormal_nociception_after | 1.71888753 |
| 22 | MP0004145_abnormal_muscle_electrophysio | 1.67102392 |
| 23 | MP0001529_abnormal_vocalization | 1.65780218 |
| 24 | MP0008872_abnormal_physiological_respon | 1.64797761 |
| 25 | MP0009697_abnormal_copulation | 1.56378275 |
| 26 | MP0000372_irregular_coat_pigmentation | 1.50382386 |
| 27 | MP0001293_anophthalmia | 1.48540579 |
| 28 | MP0005551_abnormal_eye_electrophysiolog | 1.47448757 |
| 29 | MP0002876_abnormal_thyroid_physiology | 1.46818205 |
| 30 | MP0008932_abnormal_embryonic_tissue | 1.40222247 |
| 31 | MP0006036_abnormal_mitochondrial_physio | 1.39091897 |
| 32 | MP0002837_dystrophic_cardiac_calcinosis | 1.39044590 |
| 33 | MP0002938_white_spotting | 1.37898597 |
| 34 | MP0003763_abnormal_thymus_physiology | 1.37165651 |
| 35 | MP0008875_abnormal_xenobiotic_pharmacok | 1.36180772 |
| 36 | MP0003567_abnormal_fetal_cardiomyocyte | 1.35352603 |
| 37 | MP0002210_abnormal_sex_determination | 1.30364194 |
| 38 | MP0005253_abnormal_eye_physiology | 1.26761128 |
| 39 | MP0006035_abnormal_mitochondrial_morpho | 1.24894899 |
| 40 | MP0003806_abnormal_nucleotide_metabolis | 1.24108692 |
| 41 | MP0001727_abnormal_embryo_implantation | 1.16460409 |
| 42 | MP0001929_abnormal_gametogenesis | 1.16198824 |
| 43 | MP0001873_stomach_inflammation | 1.14276996 |
| 44 | MP0001984_abnormal_olfaction | 1.09867449 |
| 45 | MP0001835_abnormal_antigen_presentation | 1.09797469 |
| 46 | MP0003119_abnormal_digestive_system | 1.08224696 |
| 47 | MP0009785_altered_susceptibility_to | 1.06152413 |
| 48 | MP0002090_abnormal_vision | 1.06148255 |
| 49 | MP0003186_abnormal_redox_activity | 1.05274071 |
| 50 | MP0005645_abnormal_hypothalamus_physiol | 1.03220083 |
| 51 | MP0001145_abnormal_male_reproductive | 1.02607366 |
| 52 | MP0003195_calcinosis | 1.02106626 |
| 53 | MP0008995_early_reproductive_senescence | 1.02102125 |
| 54 | MP0000653_abnormal_sex_gland | 0.99075248 |
| 55 | MP0001764_abnormal_homeostasis | 0.98711012 |
| 56 | MP0008007_abnormal_cellular_replicative | 0.98548580 |
| 57 | MP0002277_abnormal_respiratory_mucosa | 0.95520540 |
| 58 | MP0001346_abnormal_lacrimal_gland | 0.93998906 |
| 59 | MP0001188_hyperpigmentation | 0.93965527 |
| 60 | MP0004885_abnormal_endolymph | 0.92736764 |
| 61 | MP0005647_abnormal_sex_gland | 0.92160342 |
| 62 | MP0002751_abnormal_autonomic_nervous | 0.90574541 |
| 63 | MP0001968_abnormal_touch/_nociception | 0.87583415 |
| 64 | MP0000490_abnormal_crypts_of | 0.86281898 |
| 65 | MP0005167_abnormal_blood-brain_barrier | 0.85960874 |
| 66 | MP0005332_abnormal_amino_acid | 0.85324266 |
| 67 | MP0009333_abnormal_splenocyte_physiolog | 0.84274269 |
| 68 | MP0002653_abnormal_ependyma_morphology | 0.82826138 |
| 69 | MP0000427_abnormal_hair_cycle | 0.81627185 |
| 70 | MP0001119_abnormal_female_reproductive | 0.81120447 |
| 71 | MP0002160_abnormal_reproductive_system | 0.80544153 |
| 72 | MP0003938_abnormal_ear_development | 0.80164080 |
| 73 | MP0003698_abnormal_male_reproductive | 0.79340883 |
| 74 | MP0000358_abnormal_cell_content/ | 0.77947777 |
| 75 | MP0005377_hearing/vestibular/ear_phenot | 0.75443221 |
| 76 | MP0003878_abnormal_ear_physiology | 0.75443221 |
| 77 | MP0005379_endocrine/exocrine_gland_phen | 0.74385992 |
| 78 | MP0003937_abnormal_limbs/digits/tail_de | 0.73447576 |
| 79 | MP0005410_abnormal_fertilization | 0.73319917 |
| 80 | MP0000647_abnormal_sebaceous_gland | 0.72255100 |
| 81 | MP0001853_heart_inflammation | 0.71913864 |
| 82 | MP0010386_abnormal_urinary_bladder | 0.71449467 |
| 83 | MP0009764_decreased_sensitivity_to | 0.69995503 |
| 84 | MP0000465_gastrointestinal_hemorrhage | 0.69820047 |
| 85 | MP0002006_tumorigenesis | 0.69684714 |
| 86 | MP0000685_abnormal_immune_system | 0.66274590 |
| 87 | MP0009379_abnormal_foot_pigmentation | 0.65675437 |
| 88 | MP0003011_delayed_dark_adaptation | 0.63675020 |
| 89 | MP0001905_abnormal_dopamine_level | 0.62800710 |
| 90 | MP0001348_abnormal_lacrimal_gland | 0.62744361 |
| 91 | MP0004215_abnormal_myocardial_fiber | 0.61839592 |
| 92 | MP0005365_abnormal_bile_salt | 0.61120569 |
| 93 | MP0000313_abnormal_cell_death | 0.61037229 |
| 94 | MP0006276_abnormal_autonomic_nervous | 0.60944652 |
| 95 | MP0005389_reproductive_system_phenotype | 0.60180842 |
| 96 | MP0002148_abnormal_hypersensitivity_rea | 0.60162092 |
| 97 | MP0000049_abnormal_middle_ear | 0.59883363 |
| 98 | MP0005636_abnormal_mineral_homeostasis | 0.58920488 |
| 99 | MP0004742_abnormal_vestibular_system | 0.58853212 |
| 100 | MP0002111_abnormal_tail_morphology | 0.58563783 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Testicular atrophy (HP:0000029) | 4.30235011 |
| 2 | Lipid accumulation in hepatocytes (HP:0006561) | 4.19013216 |
| 3 | Increased hepatocellular lipid droplets (HP:0006565) | 4.10833151 |
| 4 | Mitochondrial inheritance (HP:0001427) | 3.76802548 |
| 5 | Acute necrotizing encephalopathy (HP:0006965) | 3.73027404 |
| 6 | 3-Methylglutaconic aciduria (HP:0003535) | 3.66313301 |
| 7 | Increased CSF lactate (HP:0002490) | 3.52508942 |
| 8 | Acute encephalopathy (HP:0006846) | 3.24891991 |
| 9 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.24764489 |
| 10 | Methylmalonic acidemia (HP:0002912) | 3.22055780 |
| 11 | Progressive macrocephaly (HP:0004481) | 2.98619472 |
| 12 | Reticulocytopenia (HP:0001896) | 2.93131463 |
| 13 | Renal Fanconi syndrome (HP:0001994) | 2.92646855 |
| 14 | Microvesicular hepatic steatosis (HP:0001414) | 2.91455478 |
| 15 | Hepatocellular necrosis (HP:0001404) | 2.91294092 |
| 16 | Respiratory difficulties (HP:0002880) | 2.91261921 |
| 17 | Opisthotonus (HP:0002179) | 2.89420384 |
| 18 | Meckel diverticulum (HP:0002245) | 2.80550057 |
| 19 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.77055610 |
| 20 | Increased serum lactate (HP:0002151) | 2.75031792 |
| 21 | Abnormality of the ileum (HP:0001549) | 2.68196353 |
| 22 | Chromsome breakage (HP:0040012) | 2.66469890 |
| 23 | Cerebral edema (HP:0002181) | 2.65425229 |
| 24 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.65272164 |
| 25 | Abnormality of alanine metabolism (HP:0010916) | 2.65272164 |
| 26 | Hyperalaninemia (HP:0003348) | 2.65272164 |
| 27 | Delayed CNS myelination (HP:0002188) | 2.62781357 |
| 28 | Hepatic necrosis (HP:0002605) | 2.60612040 |
| 29 | Methylmalonic aciduria (HP:0012120) | 2.53347692 |
| 30 | Type I transferrin isoform profile (HP:0003642) | 2.52089476 |
| 31 | Prostate neoplasm (HP:0100787) | 2.49812951 |
| 32 | Abnormality of the labia minora (HP:0012880) | 2.47020051 |
| 33 | Optic disc pallor (HP:0000543) | 2.44057917 |
| 34 | Increased serum pyruvate (HP:0003542) | 2.43181348 |
| 35 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.42970643 |
| 36 | Lactic acidosis (HP:0003128) | 2.39331713 |
| 37 | Abnormality of the preputium (HP:0100587) | 2.38595079 |
| 38 | Pancytopenia (HP:0001876) | 2.38438113 |
| 39 | Colon cancer (HP:0003003) | 2.36907788 |
| 40 | Exertional dyspnea (HP:0002875) | 2.35373995 |
| 41 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.33890530 |
| 42 | Visual hallucinations (HP:0002367) | 2.32513228 |
| 43 | Parakeratosis (HP:0001036) | 2.29237841 |
| 44 | Abnormal glycosylation (HP:0012345) | 2.28141435 |
| 45 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.28141435 |
| 46 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.28141435 |
| 47 | Abnormal protein glycosylation (HP:0012346) | 2.28141435 |
| 48 | Dyschromatopsia (HP:0007641) | 2.27106634 |
| 49 | Cerebral hypomyelination (HP:0006808) | 2.25577311 |
| 50 | Abolished electroretinogram (ERG) (HP:0000550) | 2.24824470 |
| 51 | Short tibia (HP:0005736) | 2.23275520 |
| 52 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.21701017 |
| 53 | Abnormality of chromosome stability (HP:0003220) | 2.20887466 |
| 54 | Congenital, generalized hypertrichosis (HP:0004540) | 2.20794942 |
| 55 | Abnormality of midbrain morphology (HP:0002418) | 2.17399150 |
| 56 | Molar tooth sign on MRI (HP:0002419) | 2.17399150 |
| 57 | Gout (HP:0001997) | 2.15871710 |
| 58 | Abnormality of glycolysis (HP:0004366) | 2.14865721 |
| 59 | Increased intramyocellular lipid droplets (HP:0012240) | 2.14589473 |
| 60 | Carpal bone hypoplasia (HP:0001498) | 2.14568812 |
| 61 | Megaloblastic anemia (HP:0001889) | 2.13422942 |
| 62 | Pendular nystagmus (HP:0012043) | 2.11313647 |
| 63 | Lethargy (HP:0001254) | 2.10480658 |
| 64 | Pancreatic cysts (HP:0001737) | 2.10025050 |
| 65 | Spastic diplegia (HP:0001264) | 2.09143780 |
| 66 | Oral leukoplakia (HP:0002745) | 2.06252143 |
| 67 | Abnormality of vitamin B metabolism (HP:0004340) | 2.03117273 |
| 68 | Congenital stationary night blindness (HP:0007642) | 2.02673974 |
| 69 | Clubbing of toes (HP:0100760) | 1.99704405 |
| 70 | Leukodystrophy (HP:0002415) | 1.99032389 |
| 71 | Increased muscle lipid content (HP:0009058) | 1.97667763 |
| 72 | Respiratory failure (HP:0002878) | 1.96947321 |
| 73 | Hypoplasia of the pons (HP:0012110) | 1.96838023 |
| 74 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.96072913 |
| 75 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.96072913 |
| 76 | Adrenal hypoplasia (HP:0000835) | 1.95503562 |
| 77 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.95149349 |
| 78 | Lissencephaly (HP:0001339) | 1.95044763 |
| 79 | Macrocytic anemia (HP:0001972) | 1.94326744 |
| 80 | Duodenal stenosis (HP:0100867) | 1.94232740 |
| 81 | Small intestinal stenosis (HP:0012848) | 1.94232740 |
| 82 | Inability to walk (HP:0002540) | 1.91176553 |
| 83 | Nephronophthisis (HP:0000090) | 1.91164630 |
| 84 | Abnormality of the prostate (HP:0008775) | 1.90238771 |
| 85 | Duplicated collecting system (HP:0000081) | 1.89589795 |
| 86 | Abnormality of serum amino acid levels (HP:0003112) | 1.88085345 |
| 87 | Amniotic constriction ring (HP:0009775) | 1.88018846 |
| 88 | Abnormality of placental membranes (HP:0011409) | 1.88018846 |
| 89 | Thyroid-stimulating hormone excess (HP:0002925) | 1.86345247 |
| 90 | Supernumerary spleens (HP:0009799) | 1.86300885 |
| 91 | Abnormality of methionine metabolism (HP:0010901) | 1.85788010 |
| 92 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.85424496 |
| 93 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.85380308 |
| 94 | CNS hypomyelination (HP:0003429) | 1.82857436 |
| 95 | Retinal dysplasia (HP:0007973) | 1.82679586 |
| 96 | Triphalangeal thumb (HP:0001199) | 1.81965993 |
| 97 | IgG deficiency (HP:0004315) | 1.81790527 |
| 98 | Abnormality of the pons (HP:0007361) | 1.81152015 |
| 99 | Autoimmune thrombocytopenia (HP:0001973) | 1.80585314 |
| 100 | Sloping forehead (HP:0000340) | 1.80277025 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K2 | 4.27643432 |
| 2 | ZAK | 3.92515806 |
| 3 | VRK2 | 3.82506613 |
| 4 | NEK1 | 3.61888023 |
| 5 | MST4 | 3.45610870 |
| 6 | BUB1 | 3.28694868 |
| 7 | TSSK6 | 3.12364287 |
| 8 | TAF1 | 2.63640378 |
| 9 | PBK | 2.56718061 |
| 10 | NUAK1 | 2.43619351 |
| 11 | TXK | 2.42014010 |
| 12 | EIF2AK3 | 2.22757411 |
| 13 | EIF2AK1 | 2.08293362 |
| 14 | SRPK1 | 2.04808599 |
| 15 | CDC7 | 2.00651198 |
| 16 | VRK1 | 1.94768095 |
| 17 | TLK1 | 1.89745565 |
| 18 | PLK3 | 1.83744827 |
| 19 | ADRBK2 | 1.69916889 |
| 20 | BCKDK | 1.57194890 |
| 21 | STK16 | 1.53545553 |
| 22 | CDK19 | 1.49391305 |
| 23 | NME1 | 1.40901723 |
| 24 | TRIM28 | 1.39365736 |
| 25 | CSNK1G3 | 1.33268109 |
| 26 | CSNK1A1L | 1.32993921 |
| 27 | PLK4 | 1.32692993 |
| 28 | OXSR1 | 1.29277101 |
| 29 | PASK | 1.28365627 |
| 30 | TTK | 1.28287344 |
| 31 | STK38L | 1.21004837 |
| 32 | MKNK1 | 1.20697456 |
| 33 | CSNK1G1 | 1.19631486 |
| 34 | DYRK2 | 1.12955996 |
| 35 | EIF2AK2 | 1.12866314 |
| 36 | GRK1 | 1.09712668 |
| 37 | PLK1 | 1.06870743 |
| 38 | WNK3 | 1.02215392 |
| 39 | CSNK1G2 | 1.00527135 |
| 40 | CASK | 0.94675146 |
| 41 | ATR | 0.92716325 |
| 42 | DAPK1 | 0.89123243 |
| 43 | WEE1 | 0.89018129 |
| 44 | CCNB1 | 0.88971746 |
| 45 | TAOK1 | 0.88318528 |
| 46 | PDK2 | 0.87984589 |
| 47 | NME2 | 0.86141624 |
| 48 | WNK4 | 0.84580938 |
| 49 | AURKA | 0.83114205 |
| 50 | MAP4K1 | 0.81653044 |
| 51 | MAP3K4 | 0.79533531 |
| 52 | BCR | 0.79087946 |
| 53 | CHEK2 | 0.78120208 |
| 54 | AURKB | 0.76379617 |
| 55 | PLK2 | 0.70493225 |
| 56 | PAK4 | 0.69241725 |
| 57 | TGFBR1 | 0.61698541 |
| 58 | MAPKAPK5 | 0.59489090 |
| 59 | STK39 | 0.58253963 |
| 60 | ATM | 0.54541726 |
| 61 | DAPK3 | 0.50311303 |
| 62 | DAPK2 | 0.48923544 |
| 63 | SMG1 | 0.48449764 |
| 64 | CSNK2A1 | 0.47742331 |
| 65 | MAP2K7 | 0.47348220 |
| 66 | IKBKB | 0.44929597 |
| 67 | CSNK2A2 | 0.43275046 |
| 68 | CSNK1A1 | 0.42957095 |
| 69 | PHKG2 | 0.42549990 |
| 70 | PHKG1 | 0.42549990 |
| 71 | ERBB4 | 0.41111273 |
| 72 | BMPR1B | 0.40328191 |
| 73 | MKNK2 | 0.39778308 |
| 74 | IRAK4 | 0.38345088 |
| 75 | PNCK | 0.38326724 |
| 76 | CHEK1 | 0.37430665 |
| 77 | IKBKE | 0.37240943 |
| 78 | CDK7 | 0.37204039 |
| 79 | ALK | 0.36765327 |
| 80 | RPS6KA5 | 0.36551586 |
| 81 | RPS6KA4 | 0.35296686 |
| 82 | TIE1 | 0.35101196 |
| 83 | DYRK3 | 0.34351642 |
| 84 | TNIK | 0.33511678 |
| 85 | BRSK2 | 0.32134249 |
| 86 | FES | 0.27980257 |
| 87 | MAPK13 | 0.27506884 |
| 88 | STK10 | 0.25246415 |
| 89 | PRKCG | 0.23943834 |
| 90 | GRK5 | 0.23899971 |
| 91 | STK4 | 0.23864504 |
| 92 | CDK9 | 0.23569202 |
| 93 | ADRBK1 | 0.23200009 |
| 94 | WNK1 | 0.22878646 |
| 95 | PRKDC | 0.22873345 |
| 96 | TEC | 0.22441503 |
| 97 | IGF1R | 0.22398676 |
| 98 | EPHB2 | 0.21841421 |
| 99 | CSNK1E | 0.21383642 |
| 100 | MAP3K14 | 0.19893536 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.00238986 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.04688432 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 2.92431251 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.74784165 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 2.71790932 |
| 6 | Ribosome_Homo sapiens_hsa03010 | 2.70130104 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 2.56614081 |
| 8 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.54736518 |
| 9 | Protein export_Homo sapiens_hsa03060 | 2.53347988 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.49677670 |
| 11 | Parkinsons disease_Homo sapiens_hsa05012 | 2.33522332 |
| 12 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.27747650 |
| 13 | Spliceosome_Homo sapiens_hsa03040 | 2.16074052 |
| 14 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.09672250 |
| 15 | RNA degradation_Homo sapiens_hsa03018 | 2.06647494 |
| 16 | Basal transcription factors_Homo sapiens_hsa03022 | 1.96556035 |
| 17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.93809628 |
| 18 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.77644216 |
| 19 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.76712153 |
| 20 | Base excision repair_Homo sapiens_hsa03410 | 1.75028902 |
| 21 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.74068921 |
| 22 | RNA transport_Homo sapiens_hsa03013 | 1.71611515 |
| 23 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.70866408 |
| 24 | Huntingtons disease_Homo sapiens_hsa05016 | 1.69092155 |
| 25 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.44446129 |
| 26 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.40067233 |
| 27 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.36083971 |
| 28 | Purine metabolism_Homo sapiens_hsa00230 | 1.35814998 |
| 29 | Alzheimers disease_Homo sapiens_hsa05010 | 1.35127850 |
| 30 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.31675666 |
| 31 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.17401243 |
| 32 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.15272277 |
| 33 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.14930822 |
| 34 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.14379446 |
| 35 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.09520894 |
| 36 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.08057842 |
| 37 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.07478067 |
| 38 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.04727156 |
| 39 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.03593003 |
| 40 | Asthma_Homo sapiens_hsa05310 | 1.02956700 |
| 41 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.00920202 |
| 42 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.00755864 |
| 43 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.98208022 |
| 44 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.97221194 |
| 45 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.92476857 |
| 46 | Peroxisome_Homo sapiens_hsa04146 | 0.91452440 |
| 47 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.88596287 |
| 48 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.88286744 |
| 49 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.87456231 |
| 50 | Phototransduction_Homo sapiens_hsa04744 | 0.86036460 |
| 51 | Cell cycle_Homo sapiens_hsa04110 | 0.85690588 |
| 52 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.81023713 |
| 53 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.80644562 |
| 54 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.76277868 |
| 55 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.75850050 |
| 56 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.75532611 |
| 57 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.72032024 |
| 58 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.71725192 |
| 59 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.70327215 |
| 60 | Metabolic pathways_Homo sapiens_hsa01100 | 0.69629773 |
| 61 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.69270958 |
| 62 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.68483197 |
| 63 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.65291383 |
| 64 | Allograft rejection_Homo sapiens_hsa05330 | 0.62476895 |
| 65 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.61770580 |
| 66 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.58463586 |
| 67 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.57121480 |
| 68 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.56343031 |
| 69 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.55891765 |
| 70 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.55377250 |
| 71 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.54235270 |
| 72 | Carbon metabolism_Homo sapiens_hsa01200 | 0.52981813 |
| 73 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.51090405 |
| 74 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.49967510 |
| 75 | Sulfur relay system_Homo sapiens_hsa04122 | 0.48955251 |
| 76 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.48859692 |
| 77 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.48126406 |
| 78 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.47387021 |
| 79 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.47077329 |
| 80 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.47023631 |
| 81 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.46538608 |
| 82 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.46090667 |
| 83 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.43319859 |
| 84 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.43184520 |
| 85 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.43150440 |
| 86 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.41634920 |
| 87 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.39561608 |
| 88 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.39217849 |
| 89 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.37418604 |
| 90 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.37129529 |
| 91 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.35731955 |
| 92 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.33543308 |
| 93 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.32284454 |
| 94 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.31117548 |
| 95 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.30670644 |
| 96 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.30323583 |
| 97 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.29643612 |
| 98 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.29583626 |
| 99 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.28530843 |
| 100 | Retinol metabolism_Homo sapiens_hsa00830 | 0.28041716 |

