ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of chronic inflammatory response (GO:0002676)	5.56737670
2	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.92594596
3	ribosome assembly (GO:0042255)	4.73886545
4	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.61917473
5	regulation of triglyceride catabolic process (GO:0010896)	4.57103182
6	regulation of isotype switching to IgG isotypes (GO:0048302)	4.50119519
7	keratinization (GO:0031424)	4.47700886
8	positive regulation of humoral immune response (GO:0002922)	4.46610892
9	response to pheromone (GO:0019236)	4.27200200
10	high-density lipoprotein particle remodeling (GO:0034375)	4.15050199
11	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	4.11323885
12	negative regulation of T-helper cell differentiation (GO:0045623)	4.11323885
13	proteasome assembly (GO:0043248)	4.10971921
14	regulation of immunoglobulin secretion (GO:0051023)	4.10512226
15	DNA deamination (GO:0045006)	4.09380600
16	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	3.76193673
17	phospholipid efflux (GO:0033700)	3.70109314
18	maturation of 5.8S rRNA (GO:0000460)	3.58060709
19	positive regulation of interleukin-17 production (GO:0032740)	3.46618488
20	heme transport (GO:0015886)	3.44007674
21	water-soluble vitamin biosynthetic process (GO:0042364)	3.43894531
22	positive regulation of isotype switching (GO:0045830)	3.40923830
23	mitochondrial RNA metabolic process (GO:0000959)	3.36296888
24	reverse cholesterol transport (GO:0043691)	3.36192644
25	negative regulation of alpha-beta T cell differentiation (GO:0046639)	3.35874214
26	positive regulation of DNA recombination (GO:0045911)	3.33465171
27	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	3.24903391
28	branched-chain amino acid catabolic process (GO:0009083)	3.18049795
29	positive regulation of immunoglobulin production (GO:0002639)	3.15218859
30	positive regulation of granulocyte differentiation (GO:0030854)	3.12048189
31	positive regulation of interleukin-8 secretion (GO:2000484)	3.06671410
32	negative regulation of epidermal cell differentiation (GO:0045605)	3.05534374
33	regulation of regulatory T cell differentiation (GO:0045589)	2.97666022
34	ribosomal large subunit biogenesis (GO:0042273)	2.94349359
35	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.92391084
36	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.92391084
37	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.92391084
38	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.89817016
39	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.88765520
40	positive regulation of protein homodimerization activity (GO:0090073)	2.86969608
41	negative regulation of NF-kappaB import into nucleus (GO:0042347)	2.85918727
42	positive regulation of B cell mediated immunity (GO:0002714)	2.76038659
43	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.76038659
44	negative regulation of B cell apoptotic process (GO:0002903)	2.72343929
45	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	2.69795525
46	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	2.69795525
47	rRNA catabolic process (GO:0016075)	2.68762285
48	rRNA modification (GO:0000154)	2.68647858
49	maturation of SSU-rRNA (GO:0030490)	2.68578038
50	positive regulation of B cell proliferation (GO:0030890)	2.66490860
51	chaperone-mediated protein transport (GO:0072321)	2.61197109
52	DNA catabolic process, exonucleolytic (GO:0000738)	2.60328812
53	positive regulation of T-helper 1 type immune response (GO:0002827)	2.58696662
54	positive regulation of activated T cell proliferation (GO:0042104)	2.57808335
55	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.57454717
56	isotype switching (GO:0045190)	2.57454717
57	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.57454717
58	RNA phosphodiester bond hydrolysis (GO:0090501)	2.57430893
59	ribosomal small subunit assembly (GO:0000028)	2.56786617
60	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.55721708
61	regulation of podosome assembly (GO:0071801)	2.55301298
62	protein K63-linked deubiquitination (GO:0070536)	2.52700755
63	GMP metabolic process (GO:0046037)	2.52236808
64	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	2.51671073
65	T-helper cell differentiation (GO:0042093)	2.51671073
66	IMP biosynthetic process (GO:0006188)	2.50625301
67	rRNA processing (GO:0006364)	2.49495875
68	regulation of cellular amino acid metabolic process (GO:0006521)	2.48603474
69	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.47429089
70	regulation of germinal center formation (GO:0002634)	2.46257031
71	branched-chain amino acid metabolic process (GO:0009081)	2.45102509
72	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.44836296
73	rRNA metabolic process (GO:0016072)	2.44574774
74	cellular response to ATP (GO:0071318)	2.42189125
75	ribosome biogenesis (GO:0042254)	2.41419901
76	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.40605669
77	cellular response to dsRNA (GO:0071359)	2.38187183
78	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.37284488
79	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.35874979
80	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.35874979
81	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.35546294
82	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.35546294
83	plasma lipoprotein particle remodeling (GO:0034369)	2.35469512
84	protein-lipid complex remodeling (GO:0034368)	2.35469512
85	macromolecular complex remodeling (GO:0034367)	2.35469512
86	DNA replication-dependent nucleosome organization (GO:0034723)	2.35198232
87	DNA replication-dependent nucleosome assembly (GO:0006335)	2.35198232
88	GTP biosynthetic process (GO:0006183)	2.34863905
89	IMP metabolic process (GO:0046040)	2.33892103
90	regulation of interleukin-8 secretion (GO:2000482)	2.33181508
91	regulation of T-helper cell differentiation (GO:0045622)	2.32349776
92	termination of RNA polymerase III transcription (GO:0006386)	2.31026585
93	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.31026585
94	regulation of T-helper 1 type immune response (GO:0002825)	2.30049753
95	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.29394989
96	regulation of cholesterol esterification (GO:0010872)	2.28747422
97	cytidine metabolic process (GO:0046087)	2.28735197
98	cytidine catabolic process (GO:0006216)	2.28735197
99	cytidine deamination (GO:0009972)	2.28735197
100	formation of translation preinitiation complex (GO:0001731)	2.28472463

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.73393144
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.08112948
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.87358544
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.01803778
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.85023920
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.78656573
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.72280003
8	VDR_23849224_ChIP-Seq_CD4+_Human	2.72190315
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.60827924
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.59366244
11	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.46292291
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.35194593
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.33991714
14	VDR_22108803_ChIP-Seq_LS180_Human	2.32847518
15	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.23867136
16	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.19247155
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.19042470
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.18991464
19	TAF15_26573619_Chip-Seq_HEK293_Human	2.18152011
20	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.10786034
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.07388319
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04797283
23	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.03072939
24	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.97583893
25	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.93782084
26	DCP1A_22483619_ChIP-Seq_HELA_Human	1.92086301
27	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.85264932
28	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.79198096
29	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.78384016
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.75567124
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.69972078
32	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.69893357
33	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.69449756
34	EWS_26573619_Chip-Seq_HEK293_Human	1.67633652
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65378030
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.64108982
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.61424887
38	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.61160166
39	GATA3_26560356_Chip-Seq_TH2_Human	1.59902670
40	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.58621213
41	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.53593901
42	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.51539744
43	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50818013
44	TTF2_22483619_ChIP-Seq_HELA_Human	1.50478732
45	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.49481325
46	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.41418309
47	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.39601492
48	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.38308767
49	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.34950209
50	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.32258181
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.31002066
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30334747
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30334747
54	FUS_26573619_Chip-Seq_HEK293_Human	1.28183523
55	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.26662423
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26417044
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26417044
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.25354773
59	GATA1_22025678_ChIP-Seq_K562_Human	1.23379306
60	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.22621963
61	MYB_26560356_Chip-Seq_TH2_Human	1.20081349
62	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19462543
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18400897
64	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.16725621
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14087242
66	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.12308284
67	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.11779130
68	RUNX_20019798_ChIP-Seq_JUKART_Human	1.11714903
69	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.10186521
70	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09907807
71	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.08763707
72	XRN2_22483619_ChIP-Seq_HELA_Human	1.07385367
73	GABP_19822575_ChIP-Seq_HepG2_Human	1.06543429
74	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04892117
75	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.04891638
76	IGF1R_20145208_ChIP-Seq_DFB_Human	1.04208860
77	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.04164763
78	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.03104788
79	GATA3_27048872_Chip-Seq_THYMUS_Human	0.99115947
80	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.98974366
81	P300_19829295_ChIP-Seq_ESCs_Human	0.98374440
82	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98101098
83	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.97894923
84	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.97474674
85	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.96807757
86	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.96442010
87	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.96300350
88	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.95077825
89	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.94513638
90	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.94409134
91	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.92853222
92	ELF5_23300383_ChIP-Seq_T47D_Human	0.92481185
93	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.92036836
94	NCOR_22424771_ChIP-Seq_293T_Human	0.91898635
95	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.91521660
96	PHF8_20622853_ChIP-Seq_HELA_Human	0.91024567
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.91009808
98	GATA3_26560356_Chip-Seq_TH1_Human	0.90175625
99	CDX2_22108803_ChIP-Seq_LS180_Human	0.88279278
100	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.87547289

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009840_abnormal_foam_cell	4.44901947
2	MP0009379_abnormal_foot_pigmentation	4.41409627
3	MP0008057_abnormal_DNA_replication	3.68976855
4	MP0001188_hyperpigmentation	3.11799397
5	MP0005084_abnormal_gallbladder_morpholo	3.07623707
6	MP0005360_urolithiasis	3.04340338
7	MP0008058_abnormal_DNA_repair	2.82439069
8	MP0001873_stomach_inflammation	2.69961621
9	MP0008875_abnormal_xenobiotic_pharmacok	2.47180558
10	MP0000383_abnormal_hair_follicle	2.35625021
11	MP0003693_abnormal_embryo_hatching	2.25646469
12	MP0008877_abnormal_DNA_methylation	2.21561113
13	MP0002876_abnormal_thyroid_physiology	2.17963330
14	MP0001835_abnormal_antigen_presentation	2.12677767
15	MP0003718_maternal_effect	2.07882866
16	MP0001348_abnormal_lacrimal_gland	1.97420371
17	MP0002102_abnormal_ear_morphology	1.92946515
18	MP0002138_abnormal_hepatobiliary_system	1.87738659
19	MP0002796_impaired_skin_barrier	1.85259355
20	MP0010678_abnormal_skin_adnexa	1.82532533
21	MP0005174_abnormal_tail_pigmentation	1.79888438
22	MP0000685_abnormal_immune_system	1.75908068
23	MP0001293_anophthalmia	1.72349520
24	MP0002396_abnormal_hematopoietic_system	1.69861189
25	MP0003300_gastrointestinal_ulcer	1.68501957
26	MP0002006_tumorigenesis	1.68250132
27	MP0000465_gastrointestinal_hemorrhage	1.66972186
28	MP0002254_reproductive_system_inflammat	1.59044260
29	MP0008872_abnormal_physiological_respon	1.58124519
30	MP0002751_abnormal_autonomic_nervous	1.46560401
31	MP0005310_abnormal_salivary_gland	1.45529462
32	MP0002148_abnormal_hypersensitivity_rea	1.40416499
33	MP0004145_abnormal_muscle_electrophysio	1.38688358
34	MP0010094_abnormal_chromosome_stability	1.36673346
35	MP0006072_abnormal_retinal_apoptosis	1.36404878
36	MP0005387_immune_system_phenotype	1.32453483
37	MP0001790_abnormal_immune_system	1.32453483
38	MP0004147_increased_porphyrin_level	1.29792350
39	MP0001800_abnormal_humoral_immune	1.28295658
40	MP0005075_abnormal_melanosome_morpholog	1.24656920
41	MP0005501_abnormal_skin_physiology	1.24486140
42	MP0000015_abnormal_ear_pigmentation	1.24245912
43	MP0000467_abnormal_esophagus_morphology	1.23272481
44	MP0003786_premature_aging	1.21755807
45	MP0004957_abnormal_blastocyst_morpholog	1.20033462
46	MP0009333_abnormal_splenocyte_physiolog	1.19042750
47	MP0002166_altered_tumor_susceptibility	1.18935180
48	MP0006082_CNS_inflammation	1.16803547
49	MP0005085_abnormal_gallbladder_physiolo	1.16573981
50	MP0003136_yellow_coat_color	1.14606892
51	MP0001663_abnormal_digestive_system	1.12139951
52	MP0004142_abnormal_muscle_tone	1.11028525
53	MP0004019_abnormal_vitamin_homeostasis	1.10340791
54	MP0005636_abnormal_mineral_homeostasis	1.09989659
55	MP0006292_abnormal_olfactory_placode	1.09266413
56	MP0002009_preneoplasia	1.09022617
57	MP0004782_abnormal_surfactant_physiolog	1.06342574
58	MP0005671_abnormal_response_to	1.05430283
59	MP0010155_abnormal_intestine_physiology	1.04895713
60	MP0003806_abnormal_nucleotide_metabolis	1.04815848
61	MP0008007_abnormal_cellular_replicative	1.04437545
62	MP0001501_abnormal_sleep_pattern	1.01517414
63	MP0002405_respiratory_system_inflammati	1.01365300
64	MP0000647_abnormal_sebaceous_gland	1.01331999
65	MP0003436_decreased_susceptibility_to	0.99080777
66	MP0003567_abnormal_fetal_cardiomyocyte	0.95119794
67	MP0006036_abnormal_mitochondrial_physio	0.93145518
68	MP0001764_abnormal_homeostasis	0.93030508
69	MP0003303_peritoneal_inflammation	0.87080017
70	MP0003077_abnormal_cell_cycle	0.85340598
71	MP0005000_abnormal_immune_tolerance	0.83759015
72	MP0006035_abnormal_mitochondrial_morpho	0.83059670
73	MP0002277_abnormal_respiratory_mucosa	0.82285589
74	MP0003111_abnormal_nucleus_morphology	0.81089361
75	MP0002139_abnormal_hepatobiliary_system	0.79809662
76	MP0002095_abnormal_skin_pigmentation	0.78833825
77	MP0002723_abnormal_immune_serum	0.78474016
78	MP0001730_embryonic_growth_arrest	0.78093420
79	MP0005332_abnormal_amino_acid	0.78002514
80	MP0005377_hearing/vestibular/ear_phenot	0.77662749
81	MP0003878_abnormal_ear_physiology	0.77662749
82	MP0000689_abnormal_spleen_morphology	0.73618586
83	MP0005389_reproductive_system_phenotype	0.72520422
84	MP0002019_abnormal_tumor_incidence	0.72080000
85	MP0010771_integument_phenotype	0.71747858
86	MP0005409_darkened_coat_color	0.71690805
87	MP0010329_abnormal_lipoprotein_level	0.71682460
88	MP0000372_irregular_coat_pigmentation	0.71577844
89	MP0001845_abnormal_inflammatory_respons	0.70884660
90	MP0002452_abnormal_antigen_presenting	0.70365830
91	MP0003950_abnormal_plasma_membrane	0.70138415
92	MP0004808_abnormal_hematopoietic_stem	0.69281569
93	MP0002398_abnormal_bone_marrow	0.69078487
94	MP0000716_abnormal_immune_system	0.68031436
95	MP0005166_decreased_susceptibility_to	0.67122471
96	MP0005551_abnormal_eye_electrophysiolog	0.67009009
97	MP0009764_decreased_sensitivity_to	0.66736155
98	MP0003045_fibrosis	0.65604458
99	MP0005381_digestive/alimentary_phenotyp	0.65418991
100	MP0002160_abnormal_reproductive_system	0.65380027

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	5.56002531
2	Pancreatic cysts (HP:0001737)	4.06765799
3	Abnormal rod and cone electroretinograms (HP:0008323)	3.65656827
4	Bile duct proliferation (HP:0001408)	3.44852425
5	Abnormal biliary tract physiology (HP:0012439)	3.44852425
6	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.40653228
7	Methylmalonic acidemia (HP:0002912)	3.37834290
8	Hyperglycinemia (HP:0002154)	3.30159888
9	Delayed CNS myelination (HP:0002188)	3.19517335
10	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.17482449
11	Pancreatic fibrosis (HP:0100732)	3.14845735
12	Abnormality of vitamin B metabolism (HP:0004340)	2.97293602
13	Posterior subcapsular cataract (HP:0007787)	2.83083817
14	True hermaphroditism (HP:0010459)	2.79429268
15	3-Methylglutaconic aciduria (HP:0003535)	2.78403365
16	Hyperglycinuria (HP:0003108)	2.76534456
17	Hypobetalipoproteinemia (HP:0003563)	2.76448632
18	Attenuation of retinal blood vessels (HP:0007843)	2.75593860
19	Abnormality of methionine metabolism (HP:0010901)	2.73085012
20	Type 2 muscle fiber atrophy (HP:0003554)	2.72916722
21	Abnormality of serine family amino acid metabolism (HP:0010894)	2.72233136
22	Abnormality of glycine metabolism (HP:0010895)	2.72233136
23	Reduced antithrombin III activity (HP:0001976)	2.70033918
24	Stomatitis (HP:0010280)	2.68922755
25	Abolished electroretinogram (ERG) (HP:0000550)	2.62987503
26	Renal cortical cysts (HP:0000803)	2.60365002
27	Oral leukoplakia (HP:0002745)	2.55838622
28	Decreased central vision (HP:0007663)	2.54888021
29	Methylmalonic aciduria (HP:0012120)	2.54569236
30	Molar tooth sign on MRI (HP:0002419)	2.50139336
31	Abnormality of midbrain morphology (HP:0002418)	2.50139336
32	Constricted visual fields (HP:0001133)	2.48142559
33	Hypoproteinemia (HP:0003075)	2.45033359
34	Absent/shortened dynein arms (HP:0200106)	2.43923347
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.43923347
36	Abnormality of serum amino acid levels (HP:0003112)	2.35371105
37	Pendular nystagmus (HP:0012043)	2.34902107
38	IgG deficiency (HP:0004315)	2.34791249
39	Increased corneal curvature (HP:0100692)	2.33032513
40	Keratoconus (HP:0000563)	2.33032513
41	Panhypogammaglobulinemia (HP:0003139)	2.28540303
42	Muscle fiber atrophy (HP:0100295)	2.27021389
43	Metaphyseal dysplasia (HP:0100255)	2.25176789
44	Abnormality of the renal cortex (HP:0011035)	2.22285981
45	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.21890045
46	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.21890045
47	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.19714335
48	Pancytopenia (HP:0001876)	2.18840095
49	Palpitations (HP:0001962)	2.17967102
50	Acute encephalopathy (HP:0006846)	2.17754190
51	Cystic liver disease (HP:0006706)	2.15650077
52	Nausea (HP:0002018)	2.15335340
53	Abnormality of the pons (HP:0007361)	2.13563976
54	Type I transferrin isoform profile (HP:0003642)	2.10397687
55	Parakeratosis (HP:0001036)	2.10174477
56	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.07707074
57	Nephronophthisis (HP:0000090)	2.06602290
58	Abnormality of macular pigmentation (HP:0008002)	2.05506387
59	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.04977617
60	Hypomagnesemia (HP:0002917)	2.04125373
61	Ependymoma (HP:0002888)	2.01792362
62	Acute necrotizing encephalopathy (HP:0006965)	1.99634223
63	Increased serum lactate (HP:0002151)	1.96463666
64	Abnormality of the prostate (HP:0008775)	1.96143660
65	Megaloblastic anemia (HP:0001889)	1.95989321
66	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.95890853
67	Increased hepatocellular lipid droplets (HP:0006565)	1.94796915
68	Elevated erythrocyte sedimentation rate (HP:0003565)	1.93112129
69	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.92872976
70	Facial hemangioma (HP:0000329)	1.92594669
71	Lipid accumulation in hepatocytes (HP:0006561)	1.91119263
72	Abnormality of vitamin metabolism (HP:0100508)	1.88028357
73	Colon cancer (HP:0003003)	1.87907664
74	Aplasia/hypoplasia of the uterus (HP:0008684)	1.86325063
75	Increased CSF lactate (HP:0002490)	1.86009740
76	Hepatocellular necrosis (HP:0001404)	1.85659593
77	Hypoplasia of the pons (HP:0012110)	1.84897997
78	Progressive inability to walk (HP:0002505)	1.84426351
79	Hepatic necrosis (HP:0002605)	1.84362623
80	Mitochondrial inheritance (HP:0001427)	1.83904028
81	Asplenia (HP:0001746)	1.83045429
82	Congenital ichthyosiform erythroderma (HP:0007431)	1.81883421
83	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.81737211
84	Furrowed tongue (HP:0000221)	1.80926192
85	Dyschromatopsia (HP:0007641)	1.80745631
86	Cerebral edema (HP:0002181)	1.79996567
87	Lactic acidosis (HP:0003128)	1.79093134
88	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.78910911
89	Optic disc pallor (HP:0000543)	1.78830424
90	Fatigue (HP:0012378)	1.77839532
91	Large for gestational age (HP:0001520)	1.75867523
92	Lethargy (HP:0001254)	1.75455283
93	Chronic hepatic failure (HP:0100626)	1.75418638
94	Tetany (HP:0001281)	1.75004431
95	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.74742400
96	Stomach cancer (HP:0012126)	1.74662610
97	Clubbing of toes (HP:0100760)	1.74343335
98	Abnormality of the renal medulla (HP:0100957)	1.73729937
99	Malnutrition (HP:0004395)	1.73446722
100	Erythroderma (HP:0001019)	1.73113450

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PBK	3.87199931
2	TSSK6	3.72399852
3	MUSK	3.12384174
4	BCKDK	3.09799150
5	PIK3CG	2.96227535
6	VRK2	2.76645716
7	MKNK1	2.56430068
8	MST4	2.51301515
9	ZAK	2.45833972
10	NUAK1	2.20241102
11	TAOK3	2.19978464
12	GRK1	1.99879666
13	NME1	1.99335311
14	STK24	1.93525546
15	NEK1	1.80834524
16	SRPK1	1.80784274
17	IKBKE	1.79125084
18	TEC	1.76796134
19	TRIM28	1.75407268
20	BUB1	1.74728715
21	TIE1	1.72103648
22	ADRBK2	1.70333672
23	IKBKB	1.67696492
24	CDC7	1.65717131
25	TLK1	1.61190984
26	EPHA2	1.60094711
27	EIF2AK3	1.57153531
28	PINK1	1.53474114
29	DYRK3	1.42889213
30	TXK	1.42404235
31	PLK3	1.37871838
32	EIF2AK2	1.34494676
33	ERBB3	1.30201471
34	VRK1	1.29330056
35	STK39	1.24104778
36	TNIK	1.18641600
37	TAF1	1.15137740
38	OXSR1	1.15081750
39	BRD4	1.13061881
40	WNK4	1.12761862
41	PASK	1.12493021
42	WNK3	1.10378402
43	ATR	1.00814220
44	STK4	1.00650137
45	CDK19	0.98081048
46	NEK9	0.96891533
47	ITK	0.96692480
48	ALK	0.94206320
49	MAPKAPK3	0.94191087
50	MKNK2	0.91539518
51	MAP4K1	0.88001629
52	STK38L	0.87295025
53	JAK3	0.85906095
54	BMPR2	0.83131946
55	CDK6	0.81911850
56	MAP4K2	0.79610693
57	RPS6KA4	0.75151711
58	TTK	0.74189019
59	IRAK4	0.71139021
60	NME2	0.70999401
61	CSNK1G1	0.70318025
62	MAP3K4	0.67522030
63	PHKG2	0.67091989
64	PHKG1	0.67091989
65	FGFR1	0.67026028
66	CSNK1G3	0.66659166
67	PLK4	0.63610569
68	ACVR1B	0.63329449
69	CSNK1A1L	0.58203097
70	DAPK1	0.55237830
71	IRAK1	0.54013624
72	PLK1	0.52653196
73	GRK6	0.51917820
74	CSNK1G2	0.48031723
75	BMPR1B	0.47058833
76	STK3	0.46797884
77	FRK	0.44952446
78	TESK2	0.43808737
79	PIM1	0.42593288
80	TGFBR1	0.42404437
81	EIF2AK1	0.41210162
82	PRKG2	0.40675281
83	RPS6KA5	0.40639766
84	CSNK2A1	0.39357530
85	PRKCE	0.37592619
86	CSNK2A2	0.36308339
87	MAP3K14	0.35005870
88	PRKCQ	0.33859503
89	FES	0.32759795
90	LCK	0.32476440
91	LYN	0.31384829
92	MAPKAPK5	0.31172643
93	NLK	0.30036803
94	BTK	0.28927934
95	CSNK1E	0.28713211
96	CDK7	0.27705533
97	ATM	0.25023727
98	ADRBK1	0.23788677
99	SIK3	0.23103081
100	CSNK1A1	0.22083471

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.96834036
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.23700509
3	Proteasome_Homo sapiens_hsa03050	3.19169698
4	Allograft rejection_Homo sapiens_hsa05330	3.11528193
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.07392474
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.99839129
7	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.63796498
8	Propanoate metabolism_Homo sapiens_hsa00640	2.23900271
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.17923806
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.17026087
11	Graft-versus-host disease_Homo sapiens_hsa05332	2.00248560
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.98637854
13	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.94252071
14	One carbon pool by folate_Homo sapiens_hsa00670	1.90410290
15	Protein export_Homo sapiens_hsa03060	1.81873404
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.75788348
17	RNA polymerase_Homo sapiens_hsa03020	1.72183587
18	RNA transport_Homo sapiens_hsa03013	1.70926954
19	RNA degradation_Homo sapiens_hsa03018	1.70790421
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.63287753
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.57516920
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.56777385
23	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.51781221
24	Basal transcription factors_Homo sapiens_hsa03022	1.47069470
25	Primary immunodeficiency_Homo sapiens_hsa05340	1.41981644
26	Fat digestion and absorption_Homo sapiens_hsa04975	1.38562193
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.34990198
28	Ribosome_Homo sapiens_hsa03010	1.31611436
29	Mismatch repair_Homo sapiens_hsa03430	1.28796811
30	Base excision repair_Homo sapiens_hsa03410	1.25455559
31	Homologous recombination_Homo sapiens_hsa03440	1.23398291
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.22337134
33	Spliceosome_Homo sapiens_hsa03040	1.21282827
34	Caffeine metabolism_Homo sapiens_hsa00232	1.20629630
35	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.16806983
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.16487088
37	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.07499597
38	Mineral absorption_Homo sapiens_hsa04978	1.07404067
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.06583249
40	Antigen processing and presentation_Homo sapiens_hsa04612	1.06062991
41	DNA replication_Homo sapiens_hsa03030	1.06038936
42	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.04667941
43	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.03976594
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.01960013
45	Arginine and proline metabolism_Homo sapiens_hsa00330	0.99619732
46	Purine metabolism_Homo sapiens_hsa00230	0.99419530
47	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.96546742
48	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.95395020
49	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.92333385
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.87678337
51	Phototransduction_Homo sapiens_hsa04744	0.86148720
52	Oxidative phosphorylation_Homo sapiens_hsa00190	0.85071651
53	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.84152910
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.81422321
55	Fanconi anemia pathway_Homo sapiens_hsa03460	0.78009361
56	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.77834118
57	Peroxisome_Homo sapiens_hsa04146	0.75443851
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74761633
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73984965
60	Fatty acid elongation_Homo sapiens_hsa00062	0.73923721
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.72699071
62	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.72222692
63	Fatty acid degradation_Homo sapiens_hsa00071	0.71775198
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70037500
65	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.69249727
66	Histidine metabolism_Homo sapiens_hsa00340	0.68797163
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.68293755
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66679916
69	Glutathione metabolism_Homo sapiens_hsa00480	0.65640720
70	Parkinsons disease_Homo sapiens_hsa05012	0.65524858
71	Sulfur metabolism_Homo sapiens_hsa00920	0.65081223
72	Retinol metabolism_Homo sapiens_hsa00830	0.63771571
73	Pyruvate metabolism_Homo sapiens_hsa00620	0.63672288
74	Galactose metabolism_Homo sapiens_hsa00052	0.62919688
75	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.62382587
76	Rheumatoid arthritis_Homo sapiens_hsa05323	0.59230594
77	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.58113614
78	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.57633737
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55321729
80	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.52688233
81	Metabolic pathways_Homo sapiens_hsa01100	0.52258643
82	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.52068970
83	Nitrogen metabolism_Homo sapiens_hsa00910	0.48791313
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48741761
85	ABC transporters_Homo sapiens_hsa02010	0.48279081
86	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.46756569
87	African trypanosomiasis_Homo sapiens_hsa05143	0.45142139
88	Herpes simplex infection_Homo sapiens_hsa05168	0.44776827
89	Huntingtons disease_Homo sapiens_hsa05016	0.44501478
90	Carbon metabolism_Homo sapiens_hsa01200	0.44381242
91	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.43365131
92	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.42678668
93	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.42099551
94	Butanoate metabolism_Homo sapiens_hsa00650	0.41567383
95	mRNA surveillance pathway_Homo sapiens_hsa03015	0.41100747
96	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.40847699
97	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.39962198
98	Viral myocarditis_Homo sapiens_hsa05416	0.38282559
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.37876076
100	Measles_Homo sapiens_hsa05162	0.36516597

HNRNPA1P27

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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