ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of isotype switching to IgG isotypes (GO:0048302)	6.82534478
2	regulation of podosome assembly (GO:0071801)	6.76258374
3	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	5.90352561
4	positive regulation of chemokine biosynthetic process (GO:0045080)	5.43663724
5	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	5.25199728
6	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	5.21492917
7	regulation of immunoglobulin secretion (GO:0051023)	5.07688706
8	positive regulation of isotype switching (GO:0045830)	4.88272436
9	regulation of chronic inflammatory response (GO:0002676)	4.86618482
10	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.65980855
11	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.57606165
12	ATP synthesis coupled proton transport (GO:0015986)	4.50200126
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.50200126
14	positive regulation of DNA recombination (GO:0045911)	4.47500914
15	regulation of vitamin D biosynthetic process (GO:0060556)	4.39161221
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.31907805
17	regulation of chemokine biosynthetic process (GO:0045073)	3.97071034
18	regulation of MHC class II biosynthetic process (GO:0045346)	3.93129668
19	ribosomal small subunit assembly (GO:0000028)	3.88921423
20	positive regulation of immunoglobulin production (GO:0002639)	3.88589416
21	negative regulation of T-helper cell differentiation (GO:0045623)	3.86382282
22	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	3.86382282
23	negative regulation of alpha-beta T cell differentiation (GO:0046639)	3.78329463
24	positive regulation of organelle assembly (GO:1902117)	3.76219797
25	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.74982453
26	ribosomal large subunit biogenesis (GO:0042273)	3.70716494
27	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.61922851
28	termination of RNA polymerase I transcription (GO:0006363)	3.60881835
29	DNA deamination (GO:0045006)	3.60455153
30	proteasome assembly (GO:0043248)	3.56707270
31	regulation of vitamin metabolic process (GO:0030656)	3.55484987
32	N-acetylglucosamine metabolic process (GO:0006044)	3.50608155
33	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.45780370
34	regulation of cellular amino acid metabolic process (GO:0006521)	3.43629263
35	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.39967211
36	microtubule depolymerization (GO:0007019)	3.38704276
37	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.38206011
38	water-soluble vitamin biosynthetic process (GO:0042364)	3.37744004
39	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.36710360
40	alpha-beta T cell differentiation involved in immune response (GO:0002293)	3.36050973
41	alpha-beta T cell activation involved in immune response (GO:0002287)	3.36050973
42	T cell differentiation involved in immune response (GO:0002292)	3.36050973
43	T cell lineage commitment (GO:0002360)	3.35820425
44	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	3.35536739
45	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.34352015
46	negative regulation of ligase activity (GO:0051352)	3.34352015
47	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.31671123
48	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.30656036
49	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.30656036
50	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.30656036
51	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.28650316
52	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.28650316
53	cytokine production involved in immune response (GO:0002367)	3.27205937
54	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.19583390
55	rRNA modification (GO:0000154)	3.19199378
56	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.18156647
57	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.18156647
58	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.17639680
59	maturation of 5.8S rRNA (GO:0000460)	3.12367797
60	rRNA processing (GO:0006364)	3.11947765
61	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.11409294
62	GDP-mannose metabolic process (GO:0019673)	3.10842631
63	kinetochore assembly (GO:0051382)	3.04857851
64	negative regulation of acute inflammatory response (GO:0002674)	3.03887460
65	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.03754478
66	termination of RNA polymerase III transcription (GO:0006386)	3.03754478
67	rRNA metabolic process (GO:0016072)	3.03397833
68	protein complex biogenesis (GO:0070271)	3.02228352
69	positive regulation of activated T cell proliferation (GO:0042104)	3.02122658
70	behavioral response to nicotine (GO:0035095)	3.01091751
71	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.97469215
72	somite development (GO:0061053)	2.94720302
73	cotranslational protein targeting to membrane (GO:0006613)	2.94663525
74	translation (GO:0006412)	2.92799104
75	neuron fate determination (GO:0048664)	2.92006472
76	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.91920479
77	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.91920479
78	chaperone-mediated protein transport (GO:0072321)	2.91111608
79	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.91052772
80	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.91052772
81	NADH dehydrogenase complex assembly (GO:0010257)	2.91052772
82	transcription from RNA polymerase I promoter (GO:0006360)	2.90454006
83	mitochondrial respiratory chain complex assembly (GO:0033108)	2.90400010
84	cellular ketone body metabolic process (GO:0046950)	2.90004164
85	viral transcription (GO:0019083)	2.89138905
86	rRNA methylation (GO:0031167)	2.88091047
87	protein targeting to ER (GO:0045047)	2.86298488
88	translational termination (GO:0006415)	2.86250367
89	regulation of proton transport (GO:0010155)	2.85523824
90	maturation of SSU-rRNA (GO:0030490)	2.84875344
91	regulation of isotype switching (GO:0045191)	2.83720880
92	positive regulation of granulocyte differentiation (GO:0030854)	2.82442149
93	spliceosomal snRNP assembly (GO:0000387)	2.82016814
94	innate immune response in mucosa (GO:0002227)	2.80608514
95	positive regulation of B cell mediated immunity (GO:0002714)	2.80411942
96	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.80411942
97	DNA replication checkpoint (GO:0000076)	2.79983965
98	transcription initiation from RNA polymerase I promoter (GO:0006361)	2.79354040
99	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.78584258
100	protein neddylation (GO:0045116)	2.78511363

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.86511894
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.54360328
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.30284257
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.79135524
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.69571000
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.06733665
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.94778118
8	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.73846665
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.69494827
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.68287160
11	E2F7_22180533_ChIP-Seq_HELA_Human	2.67057671
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.63340625
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.62371134
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.55664213
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.50261130
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.44262136
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.42202736
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.42006877
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.30757844
20	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.23062287
21	EWS_26573619_Chip-Seq_HEK293_Human	2.22062962
22	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.16977452
23	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.15839047
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14975137
25	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.09342422
26	ZNF274_21170338_ChIP-Seq_K562_Hela	1.92790083
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.92227303
28	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.86422123
29	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.85534946
30	TTF2_22483619_ChIP-Seq_HELA_Human	1.81104579
31	DCP1A_22483619_ChIP-Seq_HELA_Human	1.79099128
32	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.76317378
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.73062022
34	VDR_22108803_ChIP-Seq_LS180_Human	1.72723955
35	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.71271024
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.66074913
37	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.65993827
38	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.63883647
39	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.63080879
40	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.57872115
41	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.53795316
42	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.52123719
43	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.51708304
44	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.50187651
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.45433328
46	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.41850370
47	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.37047130
48	XRN2_22483619_ChIP-Seq_HELA_Human	1.36316764
49	FUS_26573619_Chip-Seq_HEK293_Human	1.35955809
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.35870494
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.33625351
52	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.33503800
53	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.30145045
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28279536
55	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.27745265
56	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.26582959
57	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24270559
58	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.22305791
59	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.20414725
60	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.19703803
61	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.19643901
62	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.19610397
63	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.16611047
64	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.16208773
65	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.15885879
66	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.11825980
67	GABP_19822575_ChIP-Seq_HepG2_Human	1.10450375
68	IGF1R_20145208_ChIP-Seq_DFB_Human	1.08958531
69	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.08779432
70	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.08464294
71	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.08004398
72	P300_19829295_ChIP-Seq_ESCs_Human	1.06992873
73	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.06556755
74	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.06307133
75	ERG_20517297_ChIP-Seq_VCAP_Human	1.03536051
76	ER_23166858_ChIP-Seq_MCF-7_Human	1.03426227
77	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.01459687
78	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.00599477
79	CBP_20019798_ChIP-Seq_JUKART_Human	0.98340470
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.98340470
81	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98034259
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98034259
83	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.97807692
84	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.95433061
85	SOX2_19829295_ChIP-Seq_ESCs_Human	0.94391648
86	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94391648
87	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.93942210
88	TCF4_22108803_ChIP-Seq_LS180_Human	0.93862217
89	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.92409116
90	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.90829649
91	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89306239
92	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.88530110
93	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.88107185
94	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.88107185
95	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.88107185
96	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.85565265
97	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.85338223
98	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.84609666
99	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.82659931
100	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.82587581

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001873_stomach_inflammation	6.56028300
2	MP0001348_abnormal_lacrimal_gland	4.39511714
3	MP0001835_abnormal_antigen_presentation	4.00853742
4	MP0006292_abnormal_olfactory_placode	3.43433113
5	MP0005671_abnormal_response_to	3.29019386
6	MP0008875_abnormal_xenobiotic_pharmacok	3.18867137
7	MP0008058_abnormal_DNA_repair	2.93501203
8	MP0002102_abnormal_ear_morphology	2.91942366
9	MP0002234_abnormal_pharynx_morphology	2.64825966
10	MP0008872_abnormal_physiological_respon	2.30452058
11	MP0003693_abnormal_embryo_hatching	2.07928147
12	MP0006082_CNS_inflammation	2.07700419
13	MP0005646_abnormal_pituitary_gland	2.04440211
14	MP0003283_abnormal_digestive_organ	2.02564321
15	MP0003136_yellow_coat_color	2.01163004
16	MP0010094_abnormal_chromosome_stability	1.90441335
17	MP0003786_premature_aging	1.88026069
18	MP0003938_abnormal_ear_development	1.76546092
19	MP0005084_abnormal_gallbladder_morpholo	1.74830630
20	MP0003806_abnormal_nucleotide_metabolis	1.69824845
21	MP0002736_abnormal_nociception_after	1.63983674
22	MP0008877_abnormal_DNA_methylation	1.62316248
23	MP0003567_abnormal_fetal_cardiomyocyte	1.61173352
24	MP0004142_abnormal_muscle_tone	1.57470181
25	MP0002277_abnormal_respiratory_mucosa	1.57228504
26	MP0000383_abnormal_hair_follicle	1.55151647
27	MP0003950_abnormal_plasma_membrane	1.53865329
28	MP0000049_abnormal_middle_ear	1.51270890
29	MP0002254_reproductive_system_inflammat	1.50660228
30	MP0005310_abnormal_salivary_gland	1.48154731
31	MP0009333_abnormal_splenocyte_physiolog	1.46931186
32	MP0002282_abnormal_trachea_morphology	1.46100216
33	MP0001663_abnormal_digestive_system	1.43446158
34	MP0004742_abnormal_vestibular_system	1.39020240
35	MP0001790_abnormal_immune_system	1.36352116
36	MP0005387_immune_system_phenotype	1.36352116
37	MP0003195_calcinosis	1.36127591
38	MP0004957_abnormal_blastocyst_morpholog	1.31489664
39	MP0003890_abnormal_embryonic-extraembry	1.30977187
40	MP0005645_abnormal_hypothalamus_physiol	1.28934542
41	MP0002638_abnormal_pupillary_reflex	1.28227080
42	MP0008789_abnormal_olfactory_epithelium	1.24390505
43	MP0002938_white_spotting	1.24249580
44	MP0006072_abnormal_retinal_apoptosis	1.23595569
45	MP0003718_maternal_effect	1.23083976
46	MP0003763_abnormal_thymus_physiology	1.22410831
47	MP0005551_abnormal_eye_electrophysiolog	1.21210736
48	MP0003077_abnormal_cell_cycle	1.20934325
49	MP0002160_abnormal_reproductive_system	1.19401312
50	MP0003111_abnormal_nucleus_morphology	1.16840314
51	MP0001485_abnormal_pinna_reflex	1.16065793
52	MP0000372_irregular_coat_pigmentation	1.12374278
53	MP0002148_abnormal_hypersensitivity_rea	1.07241769
54	MP0001800_abnormal_humoral_immune	1.05541159
55	MP0002751_abnormal_autonomic_nervous	1.02402418
56	MP0008995_early_reproductive_senescence	0.99669248
57	MP0005381_digestive/alimentary_phenotyp	0.99230730
58	MP0001346_abnormal_lacrimal_gland	0.99100177
59	MP0001293_anophthalmia	0.98354408
60	MP0005000_abnormal_immune_tolerance	0.96833250
61	MP0009785_altered_susceptibility_to	0.96228458
62	MP0000631_abnormal_neuroendocrine_gland	0.96024088
63	MP0002006_tumorigenesis	0.95255847
64	MP0003186_abnormal_redox_activity	0.92667366
65	MP0005253_abnormal_eye_physiology	0.91641258
66	MP0001502_abnormal_circadian_rhythm	0.88657650
67	MP0005083_abnormal_biliary_tract	0.84638898
68	MP0001968_abnormal_touch/_nociception	0.84076403
69	MP0002138_abnormal_hepatobiliary_system	0.82496588
70	MP0010678_abnormal_skin_adnexa	0.80510323
71	MP0004147_increased_porphyrin_level	0.80435027
72	MP0003119_abnormal_digestive_system	0.79936685
73	MP0009053_abnormal_anal_canal	0.78492338
74	MP0004782_abnormal_surfactant_physiolog	0.76486173
75	MP0003011_delayed_dark_adaptation	0.75502155
76	MP0003937_abnormal_limbs/digits/tail_de	0.74117646
77	MP0002166_altered_tumor_susceptibility	0.73625578
78	MP0003866_abnormal_defecation	0.73458683
79	MP0005389_reproductive_system_phenotype	0.72998351
80	MP0002405_respiratory_system_inflammati	0.71980931
81	MP0001188_hyperpigmentation	0.71606493
82	MP0002249_abnormal_larynx_morphology	0.71353306
83	MP0002210_abnormal_sex_determination	0.70498863
84	MP0002090_abnormal_vision	0.69654023
85	MP0010155_abnormal_intestine_physiology	0.69560941
86	MP0000685_abnormal_immune_system	0.65833671
87	MP0000613_abnormal_salivary_gland	0.64866272
88	MP0005499_abnormal_olfactory_system	0.63245472
89	MP0005394_taste/olfaction_phenotype	0.63245472
90	MP0008057_abnormal_DNA_replication	0.62935749
91	MP0004145_abnormal_muscle_electrophysio	0.60789246
92	MP0000470_abnormal_stomach_morphology	0.60304656
93	MP0003880_abnormal_central_pattern	0.59403682
94	MP0005167_abnormal_blood-brain_barrier	0.59112350
95	MP0002693_abnormal_pancreas_physiology	0.58848588
96	MP0006035_abnormal_mitochondrial_morpho	0.58564623
97	MP0001666_abnormal_nutrient_absorption	0.58279970
98	MP0004885_abnormal_endolymph	0.57655609
99	MP0005085_abnormal_gallbladder_physiolo	0.57606629
100	MP0002876_abnormal_thyroid_physiology	0.57467374

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reduced antithrombin III activity (HP:0001976)	3.91736041
2	Abnormality of the pons (HP:0007361)	3.80192131
3	Acute necrotizing encephalopathy (HP:0006965)	3.66790703
4	Hypoplasia of the pons (HP:0012110)	3.52856753
5	Stomatitis (HP:0010280)	3.47151348
6	Increased hepatocellular lipid droplets (HP:0006565)	3.45858242
7	Methylmalonic acidemia (HP:0002912)	3.38035625
8	Hypoproteinemia (HP:0003075)	3.19685483
9	Mitochondrial inheritance (HP:0001427)	3.19519375
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.18083825
11	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.17125923
12	Abnormality of alanine metabolism (HP:0010916)	3.17125923
13	Hyperalaninemia (HP:0003348)	3.17125923
14	Acute encephalopathy (HP:0006846)	3.10746783
15	Type I transferrin isoform profile (HP:0003642)	3.05504260
16	Increased CSF lactate (HP:0002490)	3.03389070
17	Lipid accumulation in hepatocytes (HP:0006561)	2.99580310
18	Progressive macrocephaly (HP:0004481)	2.96976309
19	3-Methylglutaconic aciduria (HP:0003535)	2.87131783
20	Visual hallucinations (HP:0002367)	2.77334429
21	Congenital, generalized hypertrichosis (HP:0004540)	2.76573405
22	B lymphocytopenia (HP:0010976)	2.73581928
23	Colon cancer (HP:0003003)	2.72844103
24	Pendular nystagmus (HP:0012043)	2.62382521
25	Exertional dyspnea (HP:0002875)	2.61887201
26	Methylmalonic aciduria (HP:0012120)	2.61453826
27	Ependymoma (HP:0002888)	2.59329589
28	Autoimmune thrombocytopenia (HP:0001973)	2.55354082
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.50573230
30	Dyschromatopsia (HP:0007641)	2.47749842
31	Increased serum lactate (HP:0002151)	2.47398083
32	Testicular atrophy (HP:0000029)	2.46971312
33	Renal Fanconi syndrome (HP:0001994)	2.45112010
34	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.45065123
35	Aplastic anemia (HP:0001915)	2.44083315
36	Hypochromic microcytic anemia (HP:0004840)	2.41657772
37	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.40680811
38	Abnormal protein N-linked glycosylation (HP:0012347)	2.40680811
39	Abnormal protein glycosylation (HP:0012346)	2.40680811
40	Abnormal glycosylation (HP:0012345)	2.40680811
41	Decreased central vision (HP:0007663)	2.39366226
42	Nephronophthisis (HP:0000090)	2.38345977
43	Abnormality of B cell number (HP:0010975)	2.38087789
44	Spastic diplegia (HP:0001264)	2.35165683
45	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.31506573
46	Large for gestational age (HP:0001520)	2.31309318
47	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.28132544
48	Confusion (HP:0001289)	2.27255470
49	Renal cortical cysts (HP:0000803)	2.26402653
50	Megaloblastic anemia (HP:0001889)	2.25975639
51	Agitation (HP:0000713)	2.24175520
52	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.24124931
53	Septo-optic dysplasia (HP:0100842)	2.23083455
54	Pancreatic cysts (HP:0001737)	2.22450969
55	Cerebral edema (HP:0002181)	2.20393266
56	Hepatocellular necrosis (HP:0001404)	2.18341957
57	Optic disc pallor (HP:0000543)	2.18283499
58	Exercise intolerance (HP:0003546)	2.18243339
59	IgG deficiency (HP:0004315)	2.17501564
60	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.17347895
61	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.17347895
62	Autoimmune hemolytic anemia (HP:0001890)	2.16800326
63	True hermaphroditism (HP:0010459)	2.15538147
64	Hypoplasia of the ulna (HP:0003022)	2.14744752
65	Aplasia/Hypoplasia of the ulna (HP:0006495)	2.13411260
66	Abnormal number of incisors (HP:0011064)	2.12010321
67	Central scotoma (HP:0000603)	2.11997473
68	Intestinal atresia (HP:0011100)	2.11933054
69	Lethargy (HP:0001254)	2.10911203
70	Abnormality of vitamin B metabolism (HP:0004340)	2.10884111
71	Thyroid-stimulating hormone excess (HP:0002925)	2.09964296
72	Macrocytic anemia (HP:0001972)	2.09568948
73	Increased intramyocellular lipid droplets (HP:0012240)	2.09478136
74	Cleft eyelid (HP:0000625)	2.08875408
75	Bilateral microphthalmos (HP:0007633)	2.05383124
76	Aplasia/hypoplasia of the uterus (HP:0008684)	2.05115214
77	Pancytopenia (HP:0001876)	2.03057356
78	Abnormality of the renal cortex (HP:0011035)	2.01641976
79	Lactic acidosis (HP:0003128)	2.01295296
80	Abnormality of serum amino acid levels (HP:0003112)	2.01289490
81	Pancreatic fibrosis (HP:0100732)	1.99429422
82	Abnormality of the labia minora (HP:0012880)	1.99076527
83	Abnormal pupillary function (HP:0007686)	1.98072853
84	Abnormality of the renal medulla (HP:0100957)	1.97111867
85	Agnosia (HP:0010524)	1.92581652
86	Respiratory failure (HP:0002878)	1.92193435
87	Asplenia (HP:0001746)	1.91893641
88	Abnormal rod and cone electroretinograms (HP:0008323)	1.90523004
89	Severe combined immunodeficiency (HP:0004430)	1.90202345
90	Abnormality of the prostate (HP:0008775)	1.90165446
91	Congenital stationary night blindness (HP:0007642)	1.90092047
92	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.90084624
93	Multiple enchondromatosis (HP:0005701)	1.89748244
94	Attenuation of retinal blood vessels (HP:0007843)	1.88682547
95	Abnormality of the ileum (HP:0001549)	1.87636229
96	Esophageal atresia (HP:0002032)	1.86305011
97	Leukodystrophy (HP:0002415)	1.86030425
98	Hepatic necrosis (HP:0002605)	1.85864009
99	Gastrointestinal atresia (HP:0002589)	1.85264677
100	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.84341637

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PBK	6.80187031
2	TXK	3.11536614
3	VRK2	3.05704504
4	TSSK6	2.89142166
5	CDK19	2.79471234
6	BUB1	2.74555233
7	NME1	2.41745268
8	MKNK1	2.38612761
9	TRIM28	2.29021743
10	ZAK	2.28399826
11	MAP4K1	2.26338114
12	TLK1	2.21287722
13	EIF2AK1	2.15937111
14	EIF2AK3	2.03121596
15	PNCK	1.96277079
16	NEK1	1.92152073
17	MST4	1.86766490
18	WEE1	1.82291140
19	TAF1	1.69086645
20	VRK1	1.65280681
21	TAOK3	1.62757999
22	TNIK	1.60509011
23	SCYL2	1.47327352
24	ADRBK2	1.46257840
25	PLK4	1.41985358
26	STK4	1.35140432
27	MAP4K2	1.34652288
28	GRK1	1.32147961
29	PLK3	1.30637213
30	BCKDK	1.30203775
31	SRPK1	1.28410280
32	MKNK2	1.25782136
33	NUAK1	1.25255895
34	CDC7	1.22720402
35	MAP3K12	1.21272892
36	BMPR2	1.16331543
37	INSRR	1.13021044
38	NME2	1.10093411
39	FRK	1.07732319
40	OXSR1	1.01710075
41	WNK3	0.98160358
42	WNK4	0.96850468
43	BRSK2	0.89451527
44	STK39	0.85071624
45	BRD4	0.82954243
46	TEC	0.78333960
47	EPHA4	0.74209051
48	PASK	0.71885442
49	MAP2K6	0.70856974
50	PLK1	0.69588153
51	IKBKB	0.69321358
52	NEK9	0.67452326
53	BMPR1B	0.60416892
54	MYLK	0.59258517
55	PAK4	0.59140302
56	KIT	0.58038768
57	DYRK3	0.57704355
58	CDK8	0.57432647
59	CHEK2	0.51276127
60	PIK3CG	0.50989436
61	ATR	0.50239069
62	ITK	0.48001868
63	BCR	0.47844663
64	PLK2	0.45611828
65	AURKB	0.45286863
66	CCNB1	0.44614848
67	BRSK1	0.44360129
68	TIE1	0.44180137
69	DYRK2	0.43906854
70	MAP3K4	0.43226854
71	MAP2K4	0.40045665
72	TTK	0.39452640
73	ALK	0.39245058
74	ADRBK1	0.39149207
75	RPS6KA5	0.38733187
76	RPS6KB1	0.38406019
77	CSNK1A1	0.37018981
78	CSNK2A2	0.36201454
79	CSNK2A1	0.36111614
80	FGFR1	0.35751475
81	ZAP70	0.35126245
82	AKT3	0.34621112
83	TNK2	0.34502627
84	EIF2AK2	0.32666148
85	CAMK2D	0.32642428
86	MUSK	0.32503186
87	MAP2K3	0.32247150
88	IRAK1	0.31984507
89	IKBKE	0.29521814
90	MAP3K5	0.28971168
91	TGFBR1	0.27802940
92	STK16	0.25841323
93	BTK	0.25340641
94	GSK3A	0.24897125
95	MAP2K7	0.24846189
96	CAMKK2	0.23726565
97	SYK	0.23398298
98	ATM	0.23283410
99	CSNK1E	0.22720598
100	AURKA	0.22619420

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.93041880
2	Ribosome_Homo sapiens_hsa03010	3.21089984
3	Asthma_Homo sapiens_hsa05310	3.12395037
4	Allograft rejection_Homo sapiens_hsa05330	3.04365087
5	RNA polymerase_Homo sapiens_hsa03020	2.99328314
6	Protein export_Homo sapiens_hsa03060	2.85595617
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.67199900
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.60683807
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.51019268
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.37576100
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.31656547
12	Mismatch repair_Homo sapiens_hsa03430	2.19279480
13	Parkinsons disease_Homo sapiens_hsa05012	2.11687277
14	DNA replication_Homo sapiens_hsa03030	2.07805850
15	Spliceosome_Homo sapiens_hsa03040	2.05055881
16	Homologous recombination_Homo sapiens_hsa03440	2.02885938
17	RNA degradation_Homo sapiens_hsa03018	2.01272823
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.87267494
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.85043698
20	RNA transport_Homo sapiens_hsa03013	1.84540925
21	Pyrimidine metabolism_Homo sapiens_hsa00240	1.62794718
22	Basal transcription factors_Homo sapiens_hsa03022	1.59772527
23	Huntingtons disease_Homo sapiens_hsa05016	1.44340061
24	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.38659319
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.28183472
26	Purine metabolism_Homo sapiens_hsa00230	1.27829211
27	Non-homologous end-joining_Homo sapiens_hsa03450	1.27202090
28	Propanoate metabolism_Homo sapiens_hsa00640	1.20184155
29	One carbon pool by folate_Homo sapiens_hsa00670	1.18371193
30	Graft-versus-host disease_Homo sapiens_hsa05332	1.17621193
31	Alzheimers disease_Homo sapiens_hsa05010	1.14799549
32	Type I diabetes mellitus_Homo sapiens_hsa04940	1.13705326
33	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.12197799
34	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.11830076
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.06594744
36	Primary immunodeficiency_Homo sapiens_hsa05340	1.04988228
37	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.03574969
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.00790492
39	Linoleic acid metabolism_Homo sapiens_hsa00591	0.99627539
40	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.96083961
41	Peroxisome_Homo sapiens_hsa04146	0.93996013
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93454244
43	Phototransduction_Homo sapiens_hsa04744	0.92465370
44	Nitrogen metabolism_Homo sapiens_hsa00910	0.90392785
45	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.87967637
46	Rheumatoid arthritis_Homo sapiens_hsa05323	0.86792715
47	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.83468750
48	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.83395290
49	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.83383090
50	Steroid biosynthesis_Homo sapiens_hsa00100	0.82864521
51	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.81835131
52	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.81541150
53	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.81156777
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.79304886
55	mRNA surveillance pathway_Homo sapiens_hsa03015	0.78753496
56	Glutathione metabolism_Homo sapiens_hsa00480	0.74974155
57	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.74706697
58	Antigen processing and presentation_Homo sapiens_hsa04612	0.72224962
59	Butanoate metabolism_Homo sapiens_hsa00650	0.71231819
60	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.69424936
61	Base excision repair_Homo sapiens_hsa03410	0.67714945
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.67414935
63	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.64917554
64	Tryptophan metabolism_Homo sapiens_hsa00380	0.62279778
65	Cardiac muscle contraction_Homo sapiens_hsa04260	0.62052405
66	Regulation of autophagy_Homo sapiens_hsa04140	0.60389664
67	Caffeine metabolism_Homo sapiens_hsa00232	0.57851164
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57848704
69	Retinol metabolism_Homo sapiens_hsa00830	0.56562227
70	Metabolic pathways_Homo sapiens_hsa01100	0.55542779
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52685648
72	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.51409037
73	Olfactory transduction_Homo sapiens_hsa04740	0.50479041
74	Cell cycle_Homo sapiens_hsa04110	0.49561785
75	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.47109034
76	Measles_Homo sapiens_hsa05162	0.46599737
77	Pyruvate metabolism_Homo sapiens_hsa00620	0.46128753
78	Fat digestion and absorption_Homo sapiens_hsa04975	0.41357163
79	Arginine and proline metabolism_Homo sapiens_hsa00330	0.41245707
80	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.40572612
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.40236501
82	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.38171624
83	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.37737920
84	Alcoholism_Homo sapiens_hsa05034	0.37548375
85	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.36090710
86	Fatty acid degradation_Homo sapiens_hsa00071	0.35779332
87	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.35163522
88	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.34433950
89	Selenocompound metabolism_Homo sapiens_hsa00450	0.33247392
90	Chemical carcinogenesis_Homo sapiens_hsa05204	0.32210285
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.30813609
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.29909488
93	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.29574503
94	Basal cell carcinoma_Homo sapiens_hsa05217	0.28475744
95	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.25684504
96	Histidine metabolism_Homo sapiens_hsa00340	0.24149104
97	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.23335370
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.22129591
99	beta-Alanine metabolism_Homo sapiens_hsa00410	0.21989432
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.21910596

HNRNPA1P28

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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