ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	phenol-containing compound catabolic process (GO:0019336)	8.17418844
2	hormone catabolic process (GO:0042447)	7.53525624
3	thyroid hormone generation (GO:0006590)	5.32190545
4	thyroid hormone metabolic process (GO:0042403)	4.78736039
5	presynaptic membrane assembly (GO:0097105)	4.51178572
6	mitotic sister chromatid cohesion (GO:0007064)	4.49266529
7	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.27606906
8	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.27606906
9	regulation of translation, ncRNA-mediated (GO:0045974)	4.27606906
10	kinetochore organization (GO:0051383)	3.96696223
11	cellular modified amino acid catabolic process (GO:0042219)	3.96325267
12	nonmotile primary cilium assembly (GO:0035058)	3.83495418
13	ganglion development (GO:0061548)	3.76623987
14	presynaptic membrane organization (GO:0097090)	3.68236417
15	meiotic chromosome segregation (GO:0045132)	3.67629413
16	protein localization to kinetochore (GO:0034501)	3.50602255
17	musculoskeletal movement (GO:0050881)	3.50368587
18	multicellular organismal movement (GO:0050879)	3.50368587
19	pre-miRNA processing (GO:0031054)	3.48828386
20	regulation of sarcomere organization (GO:0060297)	3.41131596
21	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.40687950
22	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.39357917
23	sister chromatid segregation (GO:0000819)	3.36416320
24	protein K11-linked deubiquitination (GO:0035871)	3.35768227
25	metaphase plate congression (GO:0051310)	3.35671664
26	attachment of spindle microtubules to kinetochore (GO:0008608)	3.35136815
27	neuromuscular synaptic transmission (GO:0007274)	3.34802786
28	C4-dicarboxylate transport (GO:0015740)	3.34348850
29	microtubule anchoring (GO:0034453)	3.33736420
30	mitotic metaphase plate congression (GO:0007080)	3.31410447
31	auditory behavior (GO:0031223)	3.18889257
32	regulation of centriole replication (GO:0046599)	3.18211834
33	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.10746334
34	microtubule polymerization or depolymerization (GO:0031109)	3.09467411
35	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.08511184
36	kinetochore assembly (GO:0051382)	3.07679367
37	regulation of DNA endoreduplication (GO:0032875)	3.07596023
38	mitotic sister chromatid segregation (GO:0000070)	3.04690494
39	response to pheromone (GO:0019236)	3.04084484
40	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	3.03690048
41	regulation of mitotic spindle organization (GO:0060236)	3.03528635
42	signal peptide processing (GO:0006465)	3.03483009
43	spindle checkpoint (GO:0031577)	2.94839120
44	photoreceptor cell maintenance (GO:0045494)	2.94011197
45	atrial cardiac muscle cell action potential (GO:0086014)	2.93154880
46	mechanosensory behavior (GO:0007638)	2.91480410
47	microtubule depolymerization (GO:0007019)	2.90101386
48	olfactory bulb development (GO:0021772)	2.87940079
49	DNA double-strand break processing (GO:0000729)	2.85732050
50	chromatin remodeling at centromere (GO:0031055)	2.84272920
51	nuclear pore complex assembly (GO:0051292)	2.82662650
52	replication fork processing (GO:0031297)	2.80449670
53	reflex (GO:0060004)	2.77519035
54	branched-chain amino acid catabolic process (GO:0009083)	2.77091880
55	acrosome assembly (GO:0001675)	2.76261135
56	DNA topological change (GO:0006265)	2.73170356
57	retinal rod cell development (GO:0046548)	2.73156070
58	monoubiquitinated protein deubiquitination (GO:0035520)	2.72735052
59	cellular response to sterol (GO:0036315)	2.72104726
60	ncRNA catabolic process (GO:0034661)	2.70027242
61	regulation of centrosome duplication (GO:0010824)	2.67566704
62	cranial nerve development (GO:0021545)	2.66651301
63	genitalia morphogenesis (GO:0035112)	2.65641394
64	retinal cone cell development (GO:0046549)	2.64556310
65	regulation of mesoderm development (GO:2000380)	2.63808882
66	prenylation (GO:0097354)	2.63729893
67	protein prenylation (GO:0018342)	2.63729893
68	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.60625838
69	appendage development (GO:0048736)	2.60384372
70	limb development (GO:0060173)	2.60384372
71	CENP-A containing nucleosome assembly (GO:0034080)	2.59176219
72	indole-containing compound catabolic process (GO:0042436)	2.58158189
73	indolalkylamine catabolic process (GO:0046218)	2.58158189
74	tryptophan catabolic process (GO:0006569)	2.58158189
75	regulation of spindle organization (GO:0090224)	2.58090442
76	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.57911682
77	gamma-aminobutyric acid transport (GO:0015812)	2.57870328
78	histone exchange (GO:0043486)	2.57067125
79	DNA ligation (GO:0006266)	2.52520927
80	membrane assembly (GO:0071709)	2.51786694
81	cardiac myofibril assembly (GO:0055003)	2.49974147
82	centriole replication (GO:0007099)	2.49718845
83	dorsal/ventral axis specification (GO:0009950)	2.49532781
84	mitotic spindle checkpoint (GO:0071174)	2.49284814
85	purine nucleobase biosynthetic process (GO:0009113)	2.48366778
86	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.47773616
87	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.47773616
88	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.47773616
89	regulation of timing of cell differentiation (GO:0048505)	2.47546058
90	double-strand break repair via homologous recombination (GO:0000724)	2.47245041
91	resolution of meiotic recombination intermediates (GO:0000712)	2.46025225
92	DNA damage response, detection of DNA damage (GO:0042769)	2.44837773
93	recombinational repair (GO:0000725)	2.43936024
94	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.43182019
95	innervation (GO:0060384)	2.42865373
96	DNA demethylation (GO:0080111)	2.42761421
97	nucleobase biosynthetic process (GO:0046112)	2.42343131
98	neuronal action potential propagation (GO:0019227)	2.42342488
99	myelin assembly (GO:0032288)	2.41372332
100	negative regulation of osteoblast proliferation (GO:0033689)	2.40737014

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	4.64113690
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.82905063
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.81666733
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.78913189
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.77011254
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.70717406
7	EWS_26573619_Chip-Seq_HEK293_Human	2.56282132
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.52767671
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.45726907
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.39976444
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.33350943
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.30999428
13	P300_19829295_ChIP-Seq_ESCs_Human	2.27311733
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.27103433
15	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.24390136
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.24143893
17	VDR_22108803_ChIP-Seq_LS180_Human	2.19898598
18	FUS_26573619_Chip-Seq_HEK293_Human	2.17609692
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.15868826
20	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.08955195
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.92645251
22	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.85890982
23	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.85880578
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.78978272
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.77731065
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.76584835
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.72568366
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.72340031
29	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67938580
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.66781004
31	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62319071
32	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.62306923
33	STAT3_23295773_ChIP-Seq_U87_Human	1.61100785
34	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.60389198
35	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.58675732
36	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.56331205
37	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.53676576
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.51224943
39	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.51224943
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50379028
41	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47584334
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.45418815
43	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.44388190
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.42196942
45	E2F7_22180533_ChIP-Seq_HELA_Human	1.41526019
46	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.40036967
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.39598042
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39091588
49	AR_25329375_ChIP-Seq_VCAP_Human	1.38553067
50	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.37775362
51	EZH2_22144423_ChIP-Seq_EOC_Human	1.35876357
52	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.35730274
53	IGF1R_20145208_ChIP-Seq_DFB_Human	1.35084645
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.33572715
55	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.32511225
56	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.31606827
57	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.31149464
58	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31028896
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.29934740
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.29459689
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29459689
62	TCF4_23295773_ChIP-Seq_U87_Human	1.27509730
63	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.27203919
64	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.26141056
65	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.25802730
66	TP53_16413492_ChIP-PET_HCT116_Human	1.25524968
67	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.24329623
68	TP53_18474530_ChIP-ChIP_U2OS_Human	1.24328294
69	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.23102271
70	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.21491271
71	AR_21909140_ChIP-Seq_LNCAP_Human	1.20745257
72	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.19661287
73	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.17994133
74	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16879787
75	TBL1_22424771_ChIP-Seq_293T_Human	1.16465132
76	SOX9_26525672_Chip-Seq_HEART_Mouse	1.15468498
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15166164
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15162448
79	P53_22387025_ChIP-Seq_ESCs_Mouse	1.13885712
80	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.13547163
81	RXR_22108803_ChIP-Seq_LS180_Human	1.12159752
82	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11358126
83	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.11153106
84	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.11153106
85	KDM2B_26808549_Chip-Seq_REH_Human	1.09900241
86	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.09156738
87	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.08554275
88	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.08333344
89	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.07748897
90	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.05928863
91	ELK1_19687146_ChIP-ChIP_HELA_Human	1.04246258
92	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.03932572
93	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.03921908
94	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.03558512
95	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.02789727
96	AR_21572438_ChIP-Seq_LNCaP_Human	1.02339909
97	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01771658
98	CJUN_26792858_Chip-Seq_BT549_Human	1.01092681
99	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.00301733
100	CDX2_22108803_ChIP-Seq_LS180_Human	0.99649295

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003868_abnormal_feces_composition	3.98207230
2	MP0002736_abnormal_nociception_after	3.42513700
3	MP0006072_abnormal_retinal_apoptosis	2.84597148
4	MP0008789_abnormal_olfactory_epithelium	2.74285870
5	MP0004145_abnormal_muscle_electrophysio	2.60271240
6	MP0002233_abnormal_nose_morphology	2.42675432
7	MP0005253_abnormal_eye_physiology	2.33184105
8	MP0001293_anophthalmia	2.18153191
9	MP0005499_abnormal_olfactory_system	2.15814620
10	MP0005394_taste/olfaction_phenotype	2.15814620
11	MP0006054_spinal_hemorrhage	1.99365833
12	MP0003937_abnormal_limbs/digits/tail_de	1.97315813
13	MP0001968_abnormal_touch/_nociception	1.88087948
14	MP0004084_abnormal_cardiac_muscle	1.87921691
15	MP0003890_abnormal_embryonic-extraembry	1.86336244
16	MP0008057_abnormal_DNA_replication	1.79740797
17	MP0010094_abnormal_chromosome_stability	1.71570218
18	MP0009697_abnormal_copulation	1.68177066
19	MP0005391_vision/eye_phenotype	1.59990900
20	MP0009780_abnormal_chondrocyte_physiolo	1.55465491
21	MP0002697_abnormal_eye_size	1.53343545
22	MP0000383_abnormal_hair_follicle	1.50938996
23	MP0001286_abnormal_eye_development	1.47871624
24	MP0002102_abnormal_ear_morphology	1.46372146
25	MP0001501_abnormal_sleep_pattern	1.46289526
26	MP0005551_abnormal_eye_electrophysiolog	1.45925555
27	MP0010678_abnormal_skin_adnexa	1.43062940
28	MP0000538_abnormal_urinary_bladder	1.42995639
29	MP0003950_abnormal_plasma_membrane	1.40691389
30	MP0001984_abnormal_olfaction	1.40583986
31	MP0000516_abnormal_urinary_system	1.40372743
32	MP0005367_renal/urinary_system_phenotyp	1.40372743
33	MP0010030_abnormal_orbit_morphology	1.39428797
34	MP0002928_abnormal_bile_duct	1.37525381
35	MP0003755_abnormal_palate_morphology	1.36954671
36	MP0008872_abnormal_physiological_respon	1.36948975
37	MP0001764_abnormal_homeostasis	1.33952318
38	MP0010307_abnormal_tumor_latency	1.31923100
39	MP0002751_abnormal_autonomic_nervous	1.28519001
40	MP0003077_abnormal_cell_cycle	1.27337958
41	MP0000631_abnormal_neuroendocrine_gland	1.26677694
42	MP0001299_abnormal_eye_distance/	1.23757744
43	MP0006292_abnormal_olfactory_placode	1.23587844
44	MP0000569_abnormal_digit_pigmentation	1.19951493
45	MP0002184_abnormal_innervation	1.17463793
46	MP0003111_abnormal_nucleus_morphology	1.16718240
47	MP0003718_maternal_effect	1.15855492
48	MP0005646_abnormal_pituitary_gland	1.15475297
49	MP0005195_abnormal_posterior_eye	1.15403793
50	MP0002822_catalepsy	1.15365621
51	MP0009046_muscle_twitch	1.15258537
52	MP0003195_calcinosis	1.14997615
53	MP0003941_abnormal_skin_development	1.13437505
54	MP0001485_abnormal_pinna_reflex	1.12898163
55	MP0003252_abnormal_bile_duct	1.10597452
56	MP0009703_decreased_birth_body	1.10387574
57	MP0002733_abnormal_thermal_nociception	1.08903111
58	MP0004215_abnormal_myocardial_fiber	1.08646990
59	MP0008932_abnormal_embryonic_tissue	1.08423030
60	MP0000749_muscle_degeneration	1.05796563
61	MP0008877_abnormal_DNA_methylation	1.03826299
62	MP0004133_heterotaxia	1.00745455
63	MP0003935_abnormal_craniofacial_develop	1.00569606
64	MP0000427_abnormal_hair_cycle	0.98861207
65	MP0002752_abnormal_somatic_nervous	0.98007615
66	MP0002734_abnormal_mechanical_nocicepti	0.96316520
67	MP0003119_abnormal_digestive_system	0.95571060
68	MP0002938_white_spotting	0.94444614
69	MP0003567_abnormal_fetal_cardiomyocyte	0.92958759
70	MP0002168_other_aberrant_phenotype	0.92779526
71	MP0001986_abnormal_taste_sensitivity	0.91277176
72	MP0005395_other_phenotype	0.90933842
73	MP0002111_abnormal_tail_morphology	0.90864583
74	MP0008058_abnormal_DNA_repair	0.90225331
75	MP0000428_abnormal_craniofacial_morphol	0.89622608
76	MP0003943_abnormal_hepatobiliary_system	0.89612454
77	MP0001486_abnormal_startle_reflex	0.89394827
78	MP0000566_synostosis	0.89017102
79	MP0001177_atelectasis	0.88291807
80	MP0009745_abnormal_behavioral_response	0.88172695
81	MP0001929_abnormal_gametogenesis	0.86449235
82	MP0001529_abnormal_vocalization	0.86129214
83	MP0004197_abnormal_fetal_growth/weight/	0.85832529
84	MP0004043_abnormal_pH_regulation	0.84374271
85	MP0002092_abnormal_eye_morphology	0.83932885
86	MP0003693_abnormal_embryo_hatching	0.83706060
87	MP0002127_abnormal_cardiovascular_syste	0.82695378
88	MP0002272_abnormal_nervous_system	0.82692067
89	MP0000778_abnormal_nervous_system	0.81749502
90	MP0003880_abnormal_central_pattern	0.80923333
91	MP0004270_analgesia	0.79718981
92	MP0002234_abnormal_pharynx_morphology	0.79705150
93	MP0002109_abnormal_limb_morphology	0.79629247
94	MP0010352_gastrointestinal_tract_polyps	0.79161390
95	MP0000432_abnormal_head_morphology	0.78489982
96	MP0005084_abnormal_gallbladder_morpholo	0.78392017
97	MP0002557_abnormal_social/conspecific_i	0.77767314
98	MP0005220_abnormal_exocrine_pancreas	0.76231838
99	MP0003385_abnormal_body_wall	0.76221500
100	MP0001970_abnormal_pain_threshold	0.75601313

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Popliteal pterygium (HP:0009756)	5.50488521
2	Intestinal atresia (HP:0011100)	4.23318458
3	Volvulus (HP:0002580)	4.07317020
4	Long clavicles (HP:0000890)	3.83621891
5	Bifid tongue (HP:0010297)	3.73292304
6	Hyperventilation (HP:0002883)	3.52311191
7	Cystic hygroma (HP:0000476)	3.33359468
8	Supernumerary spleens (HP:0009799)	3.32116403
9	Type 2 muscle fiber atrophy (HP:0003554)	3.04834106
10	Abnormality of the labia majora (HP:0012881)	3.00348661
11	Hypoplastic labia majora (HP:0000059)	2.93299563
12	Genital tract atresia (HP:0001827)	2.91340051
13	Medial flaring of the eyebrow (HP:0010747)	2.89656559
14	Vaginal atresia (HP:0000148)	2.89497549
15	Congenital primary aphakia (HP:0007707)	2.89327763
16	Amniotic constriction ring (HP:0009775)	2.87933400
17	Abnormality of placental membranes (HP:0011409)	2.87933400
18	Hyperglycinemia (HP:0002154)	2.84393229
19	Gait imbalance (HP:0002141)	2.82289826
20	Abnormality of the ischium (HP:0003174)	2.76373912
21	Pterygium (HP:0001059)	2.66522657
22	Tubulointerstitial nephritis (HP:0001970)	2.66494428
23	Poor coordination (HP:0002370)	2.66134138
24	Hypoplastic ischia (HP:0003175)	2.58447808
25	Aplasia of the musculature (HP:0100854)	2.55088293
26	Pancreatic islet-cell hyperplasia (HP:0004510)	2.54977290
27	Abnormal lung lobation (HP:0002101)	2.52529554
28	Chronic hepatic failure (HP:0100626)	2.47586470
29	Chorioretinal atrophy (HP:0000533)	2.44460407
30	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.43824258
31	Thyroiditis (HP:0100646)	2.41656810
32	Nephrogenic diabetes insipidus (HP:0009806)	2.38051575
33	Muscle fiber atrophy (HP:0100295)	2.35352780
34	Gastrointestinal atresia (HP:0002589)	2.34256866
35	Labial hypoplasia (HP:0000066)	2.31988896
36	Depressed nasal tip (HP:0000437)	2.29124350
37	Left ventricular hypertrophy (HP:0001712)	2.27981494
38	Abnormality of the labia minora (HP:0012880)	2.24661678
39	Aplasia/Hypoplasia of the lens (HP:0008063)	2.23290835
40	Rib fusion (HP:0000902)	2.18541184
41	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.17318620
42	Mesomelia (HP:0003027)	2.16450631
43	Gaze-evoked nystagmus (HP:0000640)	2.13555782
44	Fetal akinesia sequence (HP:0001989)	2.13219586
45	Ectopic kidney (HP:0000086)	2.08604139
46	Hypoplastic female external genitalia (HP:0012815)	2.08508363
47	Papillary thyroid carcinoma (HP:0002895)	2.08252964
48	Calf muscle hypertrophy (HP:0008981)	2.06059385
49	Abnormality of the neuromuscular junction (HP:0003398)	1.99610693
50	Fatigable weakness (HP:0003473)	1.99610693
51	Oligodactyly (hands) (HP:0001180)	1.99543954
52	Genetic anticipation (HP:0003743)	1.98614169
53	Abnormality of the pubic bones (HP:0003172)	1.95198000
54	Rhabdomyosarcoma (HP:0002859)	1.95147079
55	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.93499780
56	Increased density of long bones (HP:0006392)	1.89910655
57	Renal hypoplasia (HP:0000089)	1.88670282
58	Dyschromatopsia (HP:0007641)	1.88168761
59	Thyroid carcinoma (HP:0002890)	1.88004688
60	Nephronophthisis (HP:0000090)	1.86691827
61	Impulsivity (HP:0100710)	1.84248934
62	Small hand (HP:0200055)	1.83873884
63	Broad-based gait (HP:0002136)	1.82754141
64	Preaxial foot polydactyly (HP:0001841)	1.82268111
65	Short tibia (HP:0005736)	1.80621318
66	Chin dimple (HP:0010751)	1.79877799
67	Esophageal atresia (HP:0002032)	1.79775357
68	Hemivertebrae (HP:0002937)	1.78678008
69	Abnormality of the renal medulla (HP:0100957)	1.77408859
70	Sclerocornea (HP:0000647)	1.77065690
71	Increased nuchal translucency (HP:0010880)	1.76749554
72	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.75878374
73	Anophthalmia (HP:0000528)	1.75128305
74	Abnormality of the labia (HP:0000058)	1.74303320
75	Broad foot (HP:0001769)	1.74079214
76	Deep philtrum (HP:0002002)	1.73750014
77	Barrel-shaped chest (HP:0001552)	1.72128738
78	Neoplasm of the oral cavity (HP:0100649)	1.70840323
79	Thin ribs (HP:0000883)	1.70522428
80	Dental crowding (HP:0000678)	1.70090835
81	Stillbirth (HP:0003826)	1.69985257
82	Pancreatic cysts (HP:0001737)	1.69364422
83	Muscle hypertrophy of the lower extremities (HP:0008968)	1.68331201
84	True hermaphroditism (HP:0010459)	1.68142050
85	Cutaneous finger syndactyly (HP:0010554)	1.66589397
86	Specific learning disability (HP:0001328)	1.65233942
87	Pendular nystagmus (HP:0012043)	1.64727316
88	Neoplasm of the adrenal cortex (HP:0100641)	1.64540142
89	Postaxial hand polydactyly (HP:0001162)	1.63697720
90	Embryonal renal neoplasm (HP:0011794)	1.62755017
91	Chorioretinal coloboma (HP:0000567)	1.62566350
92	Decreased muscle mass (HP:0003199)	1.62020557
93	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.61650023
94	Bony spicule pigmentary retinopathy (HP:0007737)	1.61267171
95	Abnormality of the parathyroid morphology (HP:0011766)	1.60382051
96	Abnormal ciliary motility (HP:0012262)	1.60373787
97	Weak cry (HP:0001612)	1.60206413
98	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.59454028
99	Hypoplastic iliac wings (HP:0002866)	1.58563168
100	Anencephaly (HP:0002323)	1.58238243

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.90715861
2	NEK1	2.99417100
3	CASK	2.91631508
4	MUSK	2.81697800
5	PLK4	2.73226842
6	MKNK2	2.69914668
7	TNIK	2.69106343
8	BMPR1B	2.64325666
9	ACVR1B	2.56868018
10	EIF2AK3	2.53178422
11	BUB1	2.43631509
12	WEE1	2.38906170
13	BRD4	2.25898117
14	WNK3	2.22355250
15	MKNK1	2.17443459
16	PNCK	2.12568774
17	NUAK1	1.98448485
18	CDC7	1.74515577
19	STK38L	1.66069090
20	PLK3	1.62163351
21	PBK	1.57496083
22	BRSK2	1.49726929
23	FGFR2	1.47199546
24	ZAK	1.38695379
25	TSSK6	1.36823189
26	TTK	1.32175550
27	AKT3	1.28943303
28	MAPK13	1.25514785
29	MAP3K4	1.22141071
30	INSRR	1.19855870
31	SRPK1	1.17333804
32	SGK2	1.15338652
33	MELK	1.09188494
34	NEK2	1.05647497
35	NTRK3	1.03594559
36	TGFBR1	1.02260730
37	TAF1	0.97964209
38	PLK1	0.96049775
39	CSNK1G1	0.91594383
40	ERBB3	0.88219799
41	YES1	0.88004127
42	EPHA4	0.82084726
43	MAP4K2	0.80274771
44	EIF2AK1	0.78979475
45	PLK2	0.78715601
46	ERBB4	0.78068978
47	STK3	0.77817177
48	CDK8	0.77063996
49	PRKCG	0.74809485
50	LATS1	0.74475629
51	EIF2AK2	0.73026247
52	ATM	0.72004694
53	STK39	0.70072750
54	ATR	0.64967645
55	MAP3K12	0.63661065
56	SGK223	0.61813369
57	SGK494	0.61813369
58	FGFR1	0.61600070
59	OBSCN	0.59061084
60	ADRBK2	0.57982682
61	OXSR1	0.57027981
62	DMPK	0.56908602
63	GRK1	0.56617126
64	CHEK1	0.55618123
65	CHEK2	0.55241731
66	NLK	0.55068760
67	MET	0.54271419
68	RPS6KA4	0.52314535
69	DYRK3	0.51951030
70	PAK3	0.51334142
71	ROCK1	0.48240923
72	CDK3	0.48068502
73	AURKB	0.47029558
74	PASK	0.46278433
75	PRKCE	0.45749964
76	NEK9	0.45673111
77	MAP2K7	0.44291841
78	BRSK1	0.44266644
79	DYRK2	0.43929319
80	RAF1	0.43862156
81	SGK3	0.43113710
82	CCNB1	0.42653431
83	TNK2	0.41008848
84	ERBB2	0.40857288
85	BCR	0.39941391
86	TAOK1	0.38957267
87	SGK1	0.38940195
88	VRK1	0.38725219
89	PRKCZ	0.37804262
90	CAMK1G	0.37242917
91	PAK6	0.35156317
92	CLK1	0.34808316
93	CAMK4	0.33061987
94	CDK1	0.29383828
95	CSNK1G2	0.28115816
96	FER	0.27979125
97	CAMK2G	0.27598310
98	CDK7	0.27244344
99	CAMK2A	0.26711303
100	PRKG1	0.25195892

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Propanoate metabolism_Homo sapiens_hsa00640	3.85988751
2	Non-homologous end-joining_Homo sapiens_hsa03450	2.77892136
3	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.69357308
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.62387415
5	Nicotine addiction_Homo sapiens_hsa05033	2.47657606
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.30232943
7	Mismatch repair_Homo sapiens_hsa03430	2.11939709
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.04958365
9	Homologous recombination_Homo sapiens_hsa03440	2.04313386
10	Steroid biosynthesis_Homo sapiens_hsa00100	1.93280441
11	Fanconi anemia pathway_Homo sapiens_hsa03460	1.91805966
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.90365223
13	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.89276280
14	Butanoate metabolism_Homo sapiens_hsa00650	1.83062911
15	Cell cycle_Homo sapiens_hsa04110	1.73894217
16	Circadian rhythm_Homo sapiens_hsa04710	1.69805121
17	Lysine degradation_Homo sapiens_hsa00310	1.69335923
18	RNA degradation_Homo sapiens_hsa03018	1.68446875
19	Basal transcription factors_Homo sapiens_hsa03022	1.67590639
20	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.50610317
21	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.49873742
22	Taste transduction_Homo sapiens_hsa04742	1.45567749
23	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.44956694
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.43867279
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.43714720
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.43209302
27	DNA replication_Homo sapiens_hsa03030	1.42045704
28	p53 signaling pathway_Homo sapiens_hsa04115	1.35902883
29	Glutamatergic synapse_Homo sapiens_hsa04724	1.34170227
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.30581491
31	Protein export_Homo sapiens_hsa03060	1.28893881
32	Base excision repair_Homo sapiens_hsa03410	1.26430287
33	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.25725934
34	RNA transport_Homo sapiens_hsa03013	1.23004985
35	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.11051946
36	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.07921847
37	Fatty acid metabolism_Homo sapiens_hsa01212	1.06683063
38	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.05533530
39	One carbon pool by folate_Homo sapiens_hsa00670	1.03324062
40	RNA polymerase_Homo sapiens_hsa03020	1.02810102
41	Circadian entrainment_Homo sapiens_hsa04713	1.02047496
42	Phototransduction_Homo sapiens_hsa04744	1.01117155
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94587442
44	Melanoma_Homo sapiens_hsa05218	0.93400997
45	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.90782491
46	Nitrogen metabolism_Homo sapiens_hsa00910	0.88622462
47	Cocaine addiction_Homo sapiens_hsa05030	0.88508426
48	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.87962215
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.86372175
50	Caffeine metabolism_Homo sapiens_hsa00232	0.86148369
51	Dopaminergic synapse_Homo sapiens_hsa04728	0.84969833
52	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.83998725
53	Oocyte meiosis_Homo sapiens_hsa04114	0.83605186
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.82911200
55	Purine metabolism_Homo sapiens_hsa00230	0.80898719
56	Tight junction_Homo sapiens_hsa04530	0.80421045
57	Histidine metabolism_Homo sapiens_hsa00340	0.79506555
58	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.78415293
59	Serotonergic synapse_Homo sapiens_hsa04726	0.78069620
60	Long-term depression_Homo sapiens_hsa04730	0.71633659
61	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.71113020
62	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.70304075
63	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.67978455
64	Calcium signaling pathway_Homo sapiens_hsa04020	0.67560686
65	Adherens junction_Homo sapiens_hsa04520	0.67503274
66	cAMP signaling pathway_Homo sapiens_hsa04024	0.66675122
67	mRNA surveillance pathway_Homo sapiens_hsa03015	0.63465745
68	Amphetamine addiction_Homo sapiens_hsa05031	0.63353487
69	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.61544554
70	Hippo signaling pathway_Homo sapiens_hsa04390	0.59930725
71	GABAergic synapse_Homo sapiens_hsa04727	0.59594265
72	Alcoholism_Homo sapiens_hsa05034	0.58315953
73	Retinol metabolism_Homo sapiens_hsa00830	0.57988536
74	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.57985156
75	Fatty acid elongation_Homo sapiens_hsa00062	0.57265819
76	Morphine addiction_Homo sapiens_hsa05032	0.57226953
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56647992
78	Sulfur metabolism_Homo sapiens_hsa00920	0.55449417
79	Arginine and proline metabolism_Homo sapiens_hsa00330	0.54041550
80	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.53390007
81	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52944162
82	Basal cell carcinoma_Homo sapiens_hsa05217	0.52391720
83	MicroRNAs in cancer_Homo sapiens_hsa05206	0.51021677
84	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.49753656
85	Linoleic acid metabolism_Homo sapiens_hsa00591	0.49536792
86	Prostate cancer_Homo sapiens_hsa05215	0.48235873
87	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.47691940
88	Olfactory transduction_Homo sapiens_hsa04740	0.47252914
89	Insulin secretion_Homo sapiens_hsa04911	0.46676931
90	Colorectal cancer_Homo sapiens_hsa05210	0.46056491
91	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41883262
92	Ether lipid metabolism_Homo sapiens_hsa00565	0.41327872
93	FoxO signaling pathway_Homo sapiens_hsa04068	0.40078230
94	Wnt signaling pathway_Homo sapiens_hsa04310	0.38204369
95	Pyruvate metabolism_Homo sapiens_hsa00620	0.37516068
96	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37510443
97	Pyrimidine metabolism_Homo sapiens_hsa00240	0.37120580
98	Peroxisome_Homo sapiens_hsa04146	0.34607309
99	Type II diabetes mellitus_Homo sapiens_hsa04930	0.34437274
100	Sphingolipid metabolism_Homo sapiens_hsa00600	0.33703602

HNRNPA1P29

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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