ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.71388372
2	DNA deamination (GO:0045006)	4.52212478
3	response to pheromone (GO:0019236)	4.02362231
4	behavioral response to ethanol (GO:0048149)	3.92655677
5	platelet dense granule organization (GO:0060155)	3.92489021
6	ATP synthesis coupled proton transport (GO:0015986)	3.82226003
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.82226003
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.72987469
9	water-soluble vitamin biosynthetic process (GO:0042364)	3.61871214
10	kynurenine metabolic process (GO:0070189)	3.57805444
11	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.54723920
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.51329302
13	sulfation (GO:0051923)	3.48703831
14	fucose catabolic process (GO:0019317)	3.46958333
15	L-fucose metabolic process (GO:0042354)	3.46958333
16	L-fucose catabolic process (GO:0042355)	3.46958333
17	tryptophan catabolic process (GO:0006569)	3.46874342
18	indole-containing compound catabolic process (GO:0042436)	3.46874342
19	indolalkylamine catabolic process (GO:0046218)	3.46874342
20	piRNA metabolic process (GO:0034587)	3.44940486
21	detection of light stimulus involved in sensory perception (GO:0050962)	3.42420274
22	detection of light stimulus involved in visual perception (GO:0050908)	3.42420274
23	indolalkylamine metabolic process (GO:0006586)	3.41710033
24	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.36520319
25	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.36520319
26	nonmotile primary cilium assembly (GO:0035058)	3.27286357
27	pyrimidine nucleobase catabolic process (GO:0006208)	3.25900195
28	protein complex biogenesis (GO:0070271)	3.22430671
29	regulation of cilium movement (GO:0003352)	3.21784424
30	cytidine deamination (GO:0009972)	3.18788662
31	cytidine metabolic process (GO:0046087)	3.18788662
32	cytidine catabolic process (GO:0006216)	3.18788662
33	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.10056203
34	protein-cofactor linkage (GO:0018065)	3.07644847
35	tryptophan metabolic process (GO:0006568)	3.06696728
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.03753844
37	NADH dehydrogenase complex assembly (GO:0010257)	3.03753844
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.03753844
39	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.02706815
40	neuronal action potential (GO:0019228)	2.99804815
41	cornea development in camera-type eye (GO:0061303)	2.99457725
42	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.97352609
43	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.96691565
44	somite development (GO:0061053)	2.95929036
45	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.95538754
46	mitochondrial respiratory chain complex assembly (GO:0033108)	2.93504831
47	regulation of action potential (GO:0098900)	2.93464318
48	transmission of nerve impulse (GO:0019226)	2.88909966
49	nucleobase catabolic process (GO:0046113)	2.88516001
50	axoneme assembly (GO:0035082)	2.87673668
51	epithelial cilium movement (GO:0003351)	2.87213183
52	preassembly of GPI anchor in ER membrane (GO:0016254)	2.85194679
53	protein neddylation (GO:0045116)	2.84148180
54	mannosylation (GO:0097502)	2.81962794
55	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.81740609
56	photoreceptor cell development (GO:0042461)	2.81726636
57	dopamine transport (GO:0015872)	2.81305359
58	cellular biogenic amine catabolic process (GO:0042402)	2.80982218
59	amine catabolic process (GO:0009310)	2.80982218
60	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.79603208
61	negative regulation of telomere maintenance (GO:0032205)	2.78734009
62	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.78653039
63	cilium morphogenesis (GO:0060271)	2.74267644
64	gamma-aminobutyric acid transport (GO:0015812)	2.72255330
65	electron transport chain (GO:0022900)	2.69723485
66	negative regulation of mast cell activation (GO:0033004)	2.69631988
67	rhodopsin mediated signaling pathway (GO:0016056)	2.69294435
68	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.69139279
69	respiratory chain complex IV assembly (GO:0008535)	2.69093449
70	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.68710747
71	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.68220556
72	DNA methylation involved in gamete generation (GO:0043046)	2.67343495
73	kidney morphogenesis (GO:0060993)	2.67053290
74	regulation of microtubule-based movement (GO:0060632)	2.66949513
75	respiratory electron transport chain (GO:0022904)	2.66283870
76	synaptic transmission, cholinergic (GO:0007271)	2.65494147
77	retinal cone cell development (GO:0046549)	2.63249867
78	protein polyglutamylation (GO:0018095)	2.62664554
79	indole-containing compound metabolic process (GO:0042430)	2.62460846
80	L-methionine salvage (GO:0071267)	2.61105027
81	L-methionine biosynthetic process (GO:0071265)	2.61105027
82	amino acid salvage (GO:0043102)	2.61105027
83	cytochrome complex assembly (GO:0017004)	2.59711479
84	neural tube formation (GO:0001841)	2.53808335
85	negative regulation of appetite (GO:0032099)	2.53685036
86	negative regulation of response to food (GO:0032096)	2.53685036
87	regulation of hexokinase activity (GO:1903299)	2.53675624
88	regulation of glucokinase activity (GO:0033131)	2.53675624
89	cellular response to ATP (GO:0071318)	2.52973406
90	RNA destabilization (GO:0050779)	2.52762323
91	eye photoreceptor cell development (GO:0042462)	2.52212072
92	negative regulation of T cell differentiation in thymus (GO:0033085)	2.46480410
93	negative regulation of membrane potential (GO:0045837)	2.46046989
94	regulation of transmission of nerve impulse (GO:0051969)	2.44776628
95	cellular ketone body metabolic process (GO:0046950)	2.44266262
96	positive regulation of fatty acid transport (GO:2000193)	2.44218568
97	hindbrain development (GO:0030902)	2.43895961
98	limb bud formation (GO:0060174)	2.43253925
99	hydrogen ion transmembrane transport (GO:1902600)	2.42696157
100	positive regulation of defense response to virus by host (GO:0002230)	2.41652320

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.29880038
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.90587918
3	VDR_22108803_ChIP-Seq_LS180_Human	3.29405762
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.90501667
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.72587942
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.70658484
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.70469416
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.51172530
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.34466289
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.18057913
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.08737484
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.07981051
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.07668816
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.05451089
15	P300_19829295_ChIP-Seq_ESCs_Human	2.02294222
16	FUS_26573619_Chip-Seq_HEK293_Human	1.97340642
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.89353015
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.84719998
19	EWS_26573619_Chip-Seq_HEK293_Human	1.82840272
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.78350546
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.76754684
22	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.74125912
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62309488
24	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.59786397
25	REST_21632747_ChIP-Seq_MESCs_Mouse	1.55579194
26	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.54121312
27	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.54121312
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.53752383
29	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.53147508
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52869430
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51493161
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.47928129
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.47479092
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47479092
35	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.46540578
36	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.45824522
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44029567
38	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43852358
39	AR_25329375_ChIP-Seq_VCAP_Human	1.43215435
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.41814232
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.41814232
42	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.41228778
43	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.40132073
44	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.36730326
45	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.35667369
46	RNF2_27304074_Chip-Seq_NSC_Mouse	1.35485351
47	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.33800060
48	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.33768569
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.31303794
50	AR_21572438_ChIP-Seq_LNCaP_Human	1.29140372
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28194781
52	STAT3_23295773_ChIP-Seq_U87_Human	1.26335811
53	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26008282
54	SMAD4_21799915_ChIP-Seq_A2780_Human	1.25790275
55	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.25165927
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.25031629
57	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24605615
58	TCF4_23295773_ChIP-Seq_U87_Human	1.24081534
59	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23459687
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23459687
61	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.23298138
62	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.21930649
63	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.21747733
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21692646
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.20368447
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.19837742
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.19772368
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19375076
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19307736
70	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.18795757
71	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.18127766
72	AR_20517297_ChIP-Seq_VCAP_Human	1.17243583
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.16352826
74	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.15874516
75	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15134977
76	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.14432598
77	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.14408235
78	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13805133
79	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11044909
80	NCOR_22424771_ChIP-Seq_293T_Human	1.09690399
81	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08790429
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07714615
83	RUNX2_22187159_ChIP-Seq_PCA_Human	1.07114237
84	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06788175
85	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.03565333
86	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.03100313
87	MYC_19829295_ChIP-Seq_ESCs_Human	1.02955676
88	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00931338
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00759121
90	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.00553612
91	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.00148398
92	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.97161939
93	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.96557601
94	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96453953
95	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.96424118
96	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.95764956
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.95298567
98	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.95098038
99	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94788879
100	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.93881118

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.74510910
2	MP0005646_abnormal_pituitary_gland	2.73425629
3	MP0002102_abnormal_ear_morphology	2.58395309
4	MP0005551_abnormal_eye_electrophysiolog	2.57851866
5	MP0006072_abnormal_retinal_apoptosis	2.55014080
6	MP0001968_abnormal_touch/_nociception	2.52291284
7	MP0008875_abnormal_xenobiotic_pharmacok	2.26971860
8	MP0000372_irregular_coat_pigmentation	2.19821089
9	MP0004147_increased_porphyrin_level	2.19570624
10	MP0005645_abnormal_hypothalamus_physiol	2.10240725
11	MP0002736_abnormal_nociception_after	2.06584751
12	MP0009046_muscle_twitch	2.05521756
13	MP0003136_yellow_coat_color	2.00913402
14	MP0009745_abnormal_behavioral_response	1.92922482
15	MP0003011_delayed_dark_adaptation	1.92399639
16	MP0003646_muscle_fatigue	1.92006175
17	MP0005253_abnormal_eye_physiology	1.89423489
18	MP0002272_abnormal_nervous_system	1.88113389
19	MP0006292_abnormal_olfactory_placode	1.86329877
20	MP0003195_calcinosis	1.80187715
21	MP0002638_abnormal_pupillary_reflex	1.76870356
22	MP0001984_abnormal_olfaction	1.75882678
23	MP0004142_abnormal_muscle_tone	1.72599693
24	MP0002837_dystrophic_cardiac_calcinosis	1.72039048
25	MP0004885_abnormal_endolymph	1.68215185
26	MP0005084_abnormal_gallbladder_morpholo	1.65746860
27	MP0008872_abnormal_physiological_respon	1.65541406
28	MP0002735_abnormal_chemical_nociception	1.65054767
29	MP0002733_abnormal_thermal_nociception	1.64760789
30	MP0006276_abnormal_autonomic_nervous	1.63928539
31	MP0008789_abnormal_olfactory_epithelium	1.63073953
32	MP0002938_white_spotting	1.62704243
33	MP0001986_abnormal_taste_sensitivity	1.60574084
34	MP0000569_abnormal_digit_pigmentation	1.60019907
35	MP0003880_abnormal_central_pattern	1.53647871
36	MP0000631_abnormal_neuroendocrine_gland	1.51827924
37	MP0003787_abnormal_imprinting	1.51058998
38	MP0001501_abnormal_sleep_pattern	1.50946791
39	MP0001529_abnormal_vocalization	1.50106438
40	MP0001486_abnormal_startle_reflex	1.49395426
41	MP0002572_abnormal_emotion/affect_behav	1.46507679
42	MP0001905_abnormal_dopamine_level	1.46229285
43	MP0002557_abnormal_social/conspecific_i	1.44711951
44	MP0002064_seizures	1.39701665
45	MP0002653_abnormal_ependyma_morphology	1.35260261
46	MP0001970_abnormal_pain_threshold	1.35195147
47	MP0002876_abnormal_thyroid_physiology	1.34584088
48	MP0010386_abnormal_urinary_bladder	1.33732952
49	MP0002928_abnormal_bile_duct	1.31465250
50	MP0004145_abnormal_muscle_electrophysio	1.30572916
51	MP0000427_abnormal_hair_cycle	1.27121763
52	MP0005389_reproductive_system_phenotype	1.22068586
53	MP0003635_abnormal_synaptic_transmissio	1.20784058
54	MP0005386_behavior/neurological_phenoty	1.20649196
55	MP0004924_abnormal_behavior	1.20649196
56	MP0002160_abnormal_reproductive_system	1.20139938
57	MP0002277_abnormal_respiratory_mucosa	1.16516705
58	MP0001919_abnormal_reproductive_system	1.16385936
59	MP0005195_abnormal_posterior_eye	1.16043706
60	MP0003122_maternal_imprinting	1.15957515
61	MP0005167_abnormal_blood-brain_barrier	1.15188792
62	MP0002067_abnormal_sensory_capabilities	1.14926014
63	MP0000778_abnormal_nervous_system	1.14793644
64	MP0003718_maternal_effect	1.13103910
65	MP0002063_abnormal_learning/memory/cond	1.11929489
66	MP0005394_taste/olfaction_phenotype	1.11774926
67	MP0005499_abnormal_olfactory_system	1.11774926
68	MP0004133_heterotaxia	1.11525670
69	MP0001440_abnormal_grooming_behavior	1.10779845
70	MP0002734_abnormal_mechanical_nocicepti	1.10542975
71	MP0002234_abnormal_pharynx_morphology	1.04015657
72	MP0001485_abnormal_pinna_reflex	1.03468926
73	MP0001324_abnormal_eye_pigmentation	1.03230985
74	MP0004742_abnormal_vestibular_system	1.01700400
75	MP0002752_abnormal_somatic_nervous	1.01639555
76	MP0003121_genomic_imprinting	0.99017361
77	MP0002095_abnormal_skin_pigmentation	0.98763635
78	MP0002184_abnormal_innervation	0.98067784
79	MP0008775_abnormal_heart_ventricle	0.96095354
80	MP0002254_reproductive_system_inflammat	0.95878970
81	MP0001764_abnormal_homeostasis	0.94608350
82	MP0003878_abnormal_ear_physiology	0.93780363
83	MP0005377_hearing/vestibular/ear_phenot	0.93780363
84	MP0001502_abnormal_circadian_rhythm	0.91713617
85	MP0002138_abnormal_hepatobiliary_system	0.90637032
86	MP0005075_abnormal_melanosome_morpholog	0.90335259
87	MP0005410_abnormal_fertilization	0.88284332
88	MP0002751_abnormal_autonomic_nervous	0.86849819
89	MP0003950_abnormal_plasma_membrane	0.85811205
90	MP0000026_abnormal_inner_ear	0.83263482
91	MP0004215_abnormal_myocardial_fiber	0.81331046
92	MP0005187_abnormal_penis_morphology	0.80689737
93	MP0005391_vision/eye_phenotype	0.80662695
94	MP0005085_abnormal_gallbladder_physiolo	0.78606762
95	MP0005174_abnormal_tail_pigmentation	0.76382320
96	MP0002163_abnormal_gland_morphology	0.75994855
97	MP0000230_abnormal_systemic_arterial	0.75348266
98	MP0001963_abnormal_hearing_physiology	0.74113760
99	MP0003698_abnormal_male_reproductive	0.73842010
100	MP0001188_hyperpigmentation	0.73676069

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.65085087
2	Pancreatic cysts (HP:0001737)	4.27880792
3	Abnormality of midbrain morphology (HP:0002418)	3.86719264
4	Molar tooth sign on MRI (HP:0002419)	3.86719264
5	Pancreatic fibrosis (HP:0100732)	3.85661494
6	True hermaphroditism (HP:0010459)	3.66743828
7	Nephronophthisis (HP:0000090)	3.34456446
8	Medial flaring of the eyebrow (HP:0010747)	3.29029178
9	Gait imbalance (HP:0002141)	3.05487302
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.01260166
11	Abnormality of the renal medulla (HP:0100957)	2.94373783
12	Abnormality of the renal cortex (HP:0011035)	2.93654182
13	Attenuation of retinal blood vessels (HP:0007843)	2.87458212
14	Acute necrotizing encephalopathy (HP:0006965)	2.84629258
15	Mitochondrial inheritance (HP:0001427)	2.82336429
16	Congenital primary aphakia (HP:0007707)	2.79897877
17	Pendular nystagmus (HP:0012043)	2.76740363
18	Increased corneal curvature (HP:0100692)	2.74001864
19	Keratoconus (HP:0000563)	2.74001864
20	Decreased central vision (HP:0007663)	2.63402007
21	Sclerocornea (HP:0000647)	2.62057850
22	Acute encephalopathy (HP:0006846)	2.61084004
23	Cystic liver disease (HP:0006706)	2.60617793
24	Nephrogenic diabetes insipidus (HP:0009806)	2.57895487
25	Abnormal drinking behavior (HP:0030082)	2.55442266
26	Polydipsia (HP:0001959)	2.55442266
27	Progressive macrocephaly (HP:0004481)	2.54231045
28	Increased CSF lactate (HP:0002490)	2.54159426
29	Abolished electroretinogram (ERG) (HP:0000550)	2.48692553
30	Lipid accumulation in hepatocytes (HP:0006561)	2.48567557
31	Abnormality of the labia minora (HP:0012880)	2.47063808
32	Large for gestational age (HP:0001520)	2.43576058
33	Hyperventilation (HP:0002883)	2.41675382
34	Abnormal mitochondria in muscle tissue (HP:0008316)	2.41610285
35	Increased hepatocellular lipid droplets (HP:0006565)	2.41545648
36	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.39967536
37	Methylmalonic acidemia (HP:0002912)	2.39314874
38	Tubular atrophy (HP:0000092)	2.38226819
39	Hyperglycinemia (HP:0002154)	2.37017850
40	Chronic hepatic failure (HP:0100626)	2.36982561
41	Hepatocellular necrosis (HP:0001404)	2.36368141
42	Congenital, generalized hypertrichosis (HP:0004540)	2.34124375
43	Type II lissencephaly (HP:0007260)	2.31628784
44	Hepatic necrosis (HP:0002605)	2.29210366
45	Focal motor seizures (HP:0011153)	2.28517998
46	Concave nail (HP:0001598)	2.23815122
47	Vaginal atresia (HP:0000148)	2.22217939
48	Anencephaly (HP:0002323)	2.16821792
49	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.16213291
50	Abnormality of macular pigmentation (HP:0008002)	2.15117420
51	Limb dystonia (HP:0002451)	2.15087052
52	Genital tract atresia (HP:0001827)	2.14038911
53	Optic disc pallor (HP:0000543)	2.12167154
54	Hyperglycinuria (HP:0003108)	2.11034944
55	Oligodactyly (hands) (HP:0001180)	2.07427065
56	Congenital hepatic fibrosis (HP:0002612)	2.06300390
57	Methylmalonic aciduria (HP:0012120)	2.01822561
58	Lissencephaly (HP:0001339)	1.99319322
59	Hypothermia (HP:0002045)	1.98476209
60	Inability to walk (HP:0002540)	1.98328963
61	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.98122578
62	Polyuria (HP:0000103)	1.97935395
63	Aplasia/hypoplasia of the uterus (HP:0008684)	1.95472679
64	Patellar aplasia (HP:0006443)	1.95077987
65	Aplasia/Hypoplasia of the patella (HP:0006498)	1.92734295
66	Renal cortical cysts (HP:0000803)	1.92276817
67	Furrowed tongue (HP:0000221)	1.92004178
68	Febrile seizures (HP:0002373)	1.91799834
69	Fibular aplasia (HP:0002990)	1.88780610
70	Poor coordination (HP:0002370)	1.88208664
71	Birth length less than 3rd percentile (HP:0003561)	1.87918903
72	Male pseudohermaphroditism (HP:0000037)	1.87667933
73	Adactyly (HP:0009776)	1.87120173
74	Abnormal respiratory epithelium morphology (HP:0012253)	1.86453097
75	Abnormal respiratory motile cilium morphology (HP:0005938)	1.86453097
76	Postaxial hand polydactyly (HP:0001162)	1.84199647
77	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.83451752
78	Renal Fanconi syndrome (HP:0001994)	1.83082276
79	Abnormality of serine family amino acid metabolism (HP:0010894)	1.81491514
80	Abnormality of glycine metabolism (HP:0010895)	1.81491514
81	Postaxial foot polydactyly (HP:0001830)	1.77597270
82	3-Methylglutaconic aciduria (HP:0003535)	1.77568410
83	Tubulointerstitial fibrosis (HP:0005576)	1.77121910
84	Intestinal atresia (HP:0011100)	1.75106738
85	Progressive cerebellar ataxia (HP:0002073)	1.74239953
86	Absent/shortened dynein arms (HP:0200106)	1.73586721
87	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.73586721
88	Optic nerve hypoplasia (HP:0000609)	1.73041922
89	Azoospermia (HP:0000027)	1.72762193
90	Gaze-evoked nystagmus (HP:0000640)	1.72291513
91	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.71148986
92	Chorioretinal atrophy (HP:0000533)	1.70553451
93	Asplenia (HP:0001746)	1.69313824
94	Stomatitis (HP:0010280)	1.69008728
95	Abnormality of the renal collecting system (HP:0004742)	1.68560105
96	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.68320808
97	Thyroid-stimulating hormone excess (HP:0002925)	1.67431805
98	Focal seizures (HP:0007359)	1.66559413
99	Agitation (HP:0000713)	1.65367446
100	Bony spicule pigmentary retinopathy (HP:0007737)	1.63768860

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.99227635
2	ADRBK2	3.68813944
3	ZAK	3.40775915
4	PINK1	3.26499746
5	GRK1	2.79221328
6	BMPR1B	2.70137054
7	CASK	2.60234854
8	MAPK13	2.59838090
9	TAOK3	2.55647526
10	NUAK1	2.45518789
11	WNK3	2.37384082
12	INSRR	2.30375462
13	MAP4K2	2.25233524
14	MARK1	2.09445729
15	TLK1	1.86711166
16	WNK4	1.80892409
17	DYRK2	1.58671020
18	TNIK	1.55256938
19	DAPK2	1.46673616
20	VRK1	1.43841353
21	NME1	1.37924471
22	STK39	1.31105550
23	BCKDK	1.28279991
24	MAP3K4	1.23330823
25	ADRBK1	1.22893994
26	TXK	1.21639697
27	TGFBR1	1.20712020
28	NTRK2	1.20044643
29	VRK2	1.18221926
30	STK16	1.14005904
31	ACVR1B	1.13727693
32	PRKCG	1.13043651
33	MAPK15	1.11081882
34	TRIM28	1.09541394
35	PAK3	1.07398741
36	OXSR1	1.06364657
37	NTRK3	1.05473098
38	TNK2	0.99558334
39	MKNK2	0.98444780
40	PLK3	0.89706873
41	PLK2	0.87906134
42	PRKCE	0.87815513
43	PRKCQ	0.87616751
44	TIE1	0.87116995
45	PKN1	0.81409116
46	EIF2AK3	0.79635649
47	MAP2K7	0.78935319
48	TAF1	0.77976234
49	PTK2B	0.77848946
50	STK38L	0.77556836
51	IRAK1	0.72505016
52	PHKG2	0.72294676
53	PHKG1	0.72294676
54	MAPKAPK3	0.72273992
55	LIMK1	0.70644161
56	FGFR2	0.69705867
57	CSNK1G2	0.68669924
58	MAPKAPK5	0.64745021
59	KDR	0.63879462
60	CAMK2A	0.63852184
61	CAMKK2	0.62921035
62	KIT	0.60130172
63	PLK4	0.59088365
64	PASK	0.58833083
65	CSNK1G1	0.58045859
66	RPS6KA5	0.57154442
67	PIK3CA	0.56935795
68	PNCK	0.56829830
69	IKBKB	0.55532002
70	GRK7	0.55342439
71	TEC	0.54782136
72	CSNK1G3	0.54192788
73	DYRK1A	0.51418421
74	MKNK1	0.50932326
75	BRSK2	0.50246351
76	PRKACA	0.49786062
77	BCR	0.49109938
78	PRKCI	0.49067480
79	ERBB3	0.48835896
80	MAP2K6	0.48327490
81	EPHA4	0.44952084
82	CSNK1A1L	0.44832129
83	MST4	0.43658302
84	GRK5	0.42907563
85	PRKCZ	0.41793407
86	EPHB2	0.41494964
87	CSNK1A1	0.37852095
88	CHEK2	0.37490995
89	TYRO3	0.37087898
90	PRKCA	0.36009378
91	CHUK	0.35680111
92	CAMK1	0.34991604
93	PRKCH	0.34966871
94	AKT3	0.34694962
95	SYK	0.32727685
96	WEE1	0.31927811
97	CAMKK1	0.31913563
98	CSNK1D	0.31132279
99	EIF2AK2	0.31060036
100	CDK8	0.29931396

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	3.66904363
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.13212939
3	Phototransduction_Homo sapiens_hsa04744	2.87999752
4	Parkinsons disease_Homo sapiens_hsa05012	2.61736307
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.56299060
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.48394340
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.42143717
8	Nicotine addiction_Homo sapiens_hsa05033	2.34739002
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.26447883
10	Protein export_Homo sapiens_hsa03060	2.12634511
11	Butanoate metabolism_Homo sapiens_hsa00650	2.10508639
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.03271591
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.98997784
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.96737799
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.93043253
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.84508221
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.73516180
18	Alzheimers disease_Homo sapiens_hsa05010	1.71098607
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.68799121
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.63349389
21	RNA polymerase_Homo sapiens_hsa03020	1.59444008
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.57920591
23	Huntingtons disease_Homo sapiens_hsa05016	1.54383759
24	Basal transcription factors_Homo sapiens_hsa03022	1.48076606
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.40916654
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.40063363
27	Taste transduction_Homo sapiens_hsa04742	1.37129272
28	Propanoate metabolism_Homo sapiens_hsa00640	1.36642864
29	Morphine addiction_Homo sapiens_hsa05032	1.34464617
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.31838845
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.29479838
32	Proteasome_Homo sapiens_hsa03050	1.29468526
33	Olfactory transduction_Homo sapiens_hsa04740	1.27519521
34	Ribosome_Homo sapiens_hsa03010	1.27344294
35	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.22528090
36	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.14738041
37	RNA degradation_Homo sapiens_hsa03018	1.13526668
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.11341066
39	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.09718069
40	Homologous recombination_Homo sapiens_hsa03440	1.08416161
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.06358808
42	Peroxisome_Homo sapiens_hsa04146	1.06177676
43	Primary immunodeficiency_Homo sapiens_hsa05340	1.03807553
44	One carbon pool by folate_Homo sapiens_hsa00670	1.03779377
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01492295
46	Serotonergic synapse_Homo sapiens_hsa04726	0.99449855
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.99322432
48	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.99321075
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.98047272
50	GABAergic synapse_Homo sapiens_hsa04727	0.95391807
51	Glutamatergic synapse_Homo sapiens_hsa04724	0.94790904
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.94744902
53	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.90071193
54	Circadian entrainment_Homo sapiens_hsa04713	0.88779288
55	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.88245154
56	Fat digestion and absorption_Homo sapiens_hsa04975	0.86327190
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83676663
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.81534936
59	Retinol metabolism_Homo sapiens_hsa00830	0.80518386
60	Insulin secretion_Homo sapiens_hsa04911	0.77055443
61	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.76459035
62	ABC transporters_Homo sapiens_hsa02010	0.72304901
63	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.69315535
64	Salivary secretion_Homo sapiens_hsa04970	0.68626955
65	Metabolic pathways_Homo sapiens_hsa01100	0.66506727
66	Folate biosynthesis_Homo sapiens_hsa00790	0.66332544
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.65789833
68	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65349649
69	Mineral absorption_Homo sapiens_hsa04978	0.64350457
70	Asthma_Homo sapiens_hsa05310	0.63015268
71	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.62259334
72	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.61177351
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.59810348
74	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.58916263
75	Graft-versus-host disease_Homo sapiens_hsa05332	0.57912427
76	Regulation of autophagy_Homo sapiens_hsa04140	0.57519675
77	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.56323352
78	Purine metabolism_Homo sapiens_hsa00230	0.55658199
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.53286044
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.52438641
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.51596573
82	Cocaine addiction_Homo sapiens_hsa05030	0.50980455
83	Dopaminergic synapse_Homo sapiens_hsa04728	0.50979277
84	Type I diabetes mellitus_Homo sapiens_hsa04940	0.46866614
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.46810820
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.46671091
87	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.46256433
88	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.43934340
89	Amphetamine addiction_Homo sapiens_hsa05031	0.41601496
90	Fatty acid degradation_Homo sapiens_hsa00071	0.38320239
91	Cholinergic synapse_Homo sapiens_hsa04725	0.38211794
92	Histidine metabolism_Homo sapiens_hsa00340	0.37885065
93	Sphingolipid metabolism_Homo sapiens_hsa00600	0.37007260
94	Rheumatoid arthritis_Homo sapiens_hsa05323	0.36344367
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34588864
96	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.34173778
97	Antigen processing and presentation_Homo sapiens_hsa04612	0.33910576
98	Sulfur metabolism_Homo sapiens_hsa00920	0.31601236
99	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.31201567
100	Steroid biosynthesis_Homo sapiens_hsa00100	0.29332009

HNRNPA1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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