Rank | Gene Set | Z-score |
---|---|---|
1 | response to pheromone (GO:0019236) | 5.79169804 |
2 | regulation of isotype switching to IgG isotypes (GO:0048302) | 4.83532154 |
3 | base-excision repair, AP site formation (GO:0006285) | 4.69715666 |
4 | DNA deamination (GO:0045006) | 4.57024964 |
5 | L-fucose catabolic process (GO:0042355) | 4.52196208 |
6 | fucose catabolic process (GO:0019317) | 4.52196208 |
7 | L-fucose metabolic process (GO:0042354) | 4.52196208 |
8 | rRNA catabolic process (GO:0016075) | 4.23188788 |
9 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.22900364 |
10 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.22900364 |
11 | NADH dehydrogenase complex assembly (GO:0010257) | 4.22900364 |
12 | DNA catabolic process, exonucleolytic (GO:0000738) | 4.04439892 |
13 | protein complex biogenesis (GO:0070271) | 3.97463382 |
14 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.96875454 |
15 | regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339 | 3.94944455 |
16 | respiratory chain complex IV assembly (GO:0008535) | 3.92435564 |
17 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.92391669 |
18 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.89851897 |
19 | maturation of 5.8S rRNA (GO:0000460) | 3.83892008 |
20 | vitamin transmembrane transport (GO:0035461) | 3.75490546 |
21 | rRNA modification (GO:0000154) | 3.72730067 |
22 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.69686417 |
23 | regulation of podosome assembly (GO:0071801) | 3.58788254 |
24 | rRNA methylation (GO:0031167) | 3.41355655 |
25 | cullin deneddylation (GO:0010388) | 3.40762450 |
26 | cellular ketone body metabolic process (GO:0046950) | 3.39582321 |
27 | cytochrome complex assembly (GO:0017004) | 3.37525214 |
28 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.36515407 |
29 | ribosomal small subunit assembly (GO:0000028) | 3.35329888 |
30 | DNA double-strand break processing (GO:0000729) | 3.35194867 |
31 | chaperone-mediated protein transport (GO:0072321) | 3.31727766 |
32 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.28280673 |
33 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.27276251 |
34 | DNA damage response, detection of DNA damage (GO:0042769) | 3.26016037 |
35 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.25841653 |
36 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.16390307 |
37 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.14884398 |
38 | proteasome assembly (GO:0043248) | 3.14391593 |
39 | regulation of memory T cell differentiation (GO:0043380) | 3.12352999 |
40 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.09854488 |
41 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.09854488 |
42 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.09854488 |
43 | protein deneddylation (GO:0000338) | 3.08427354 |
44 | aldehyde catabolic process (GO:0046185) | 3.07209504 |
45 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.05101655 |
46 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.05101655 |
47 | protein K6-linked ubiquitination (GO:0085020) | 3.05088597 |
48 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.04891666 |
49 | DNA replication checkpoint (GO:0000076) | 3.03276659 |
50 | positive regulation of chemokine biosynthetic process (GO:0045080) | 3.01954226 |
51 | fucosylation (GO:0036065) | 3.01154167 |
52 | ubiquinone biosynthetic process (GO:0006744) | 2.99722210 |
53 | intracellular protein transmembrane import (GO:0044743) | 2.98844404 |
54 | pyrimidine-containing compound transmembrane transport (GO:0072531) | 2.98801332 |
55 | ketone body metabolic process (GO:1902224) | 2.97812698 |
56 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.95932635 |
57 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.93353096 |
58 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.93353096 |
59 | negative regulation of ligase activity (GO:0051352) | 2.93055777 |
60 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.93055777 |
61 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.92165764 |
62 | ribosomal large subunit biogenesis (GO:0042273) | 2.90270519 |
63 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.89828699 |
64 | signal peptide processing (GO:0006465) | 2.88601870 |
65 | behavioral response to nicotine (GO:0035095) | 2.88085475 |
66 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.87761330 |
67 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.87761330 |
68 | IMP biosynthetic process (GO:0006188) | 2.86690594 |
69 | rRNA metabolic process (GO:0016072) | 2.85671413 |
70 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 2.82892112 |
71 | mitochondrial RNA metabolic process (GO:0000959) | 2.82696085 |
72 | rRNA processing (GO:0006364) | 2.82070477 |
73 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.78961258 |
74 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.78072450 |
75 | termination of RNA polymerase III transcription (GO:0006386) | 2.78072450 |
76 | protein neddylation (GO:0045116) | 2.77682744 |
77 | replication fork processing (GO:0031297) | 2.77550705 |
78 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.77433018 |
79 | maturation of SSU-rRNA (GO:0030490) | 2.76791195 |
80 | spliceosomal snRNP assembly (GO:0000387) | 2.75377511 |
81 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.74952678 |
82 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.74952678 |
83 | ncRNA catabolic process (GO:0034661) | 2.74039540 |
84 | negative regulation of thymocyte apoptotic process (GO:0070244) | 2.73394697 |
85 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.73377278 |
86 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 2.73237282 |
87 | histone-serine phosphorylation (GO:0035404) | 2.72870923 |
88 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.72500904 |
89 | ATP synthesis coupled proton transport (GO:0015986) | 2.72500904 |
90 | regulation of chronic inflammatory response (GO:0002676) | 2.72464594 |
91 | positive regulation of isotype switching (GO:0045830) | 2.69174154 |
92 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.68850771 |
93 | spliceosomal complex assembly (GO:0000245) | 2.67658757 |
94 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.66953081 |
95 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 2.64918619 |
96 | quinone biosynthetic process (GO:1901663) | 2.64312200 |
97 | regulation of MHC class II biosynthetic process (GO:0045346) | 2.63969983 |
98 | chromatin remodeling at centromere (GO:0031055) | 2.62350121 |
99 | ubiquinone metabolic process (GO:0006743) | 2.61271805 |
100 | protein-cofactor linkage (GO:0018065) | 2.60731314 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 5.78952853 |
2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.38167820 |
3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.00343068 |
4 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.77232522 |
5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.63263236 |
6 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.41442304 |
7 | VDR_22108803_ChIP-Seq_LS180_Human | 3.25756286 |
8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.10796404 |
9 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.79410665 |
10 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.64039147 |
11 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.53224161 |
12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.52371612 |
13 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.47883555 |
14 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.41833960 |
15 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.33769860 |
16 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.32201075 |
17 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.28234110 |
18 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.11673360 |
19 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.11604831 |
20 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.08370273 |
21 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.96860308 |
22 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.87676149 |
23 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.86517675 |
24 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.86139332 |
25 | EWS_26573619_Chip-Seq_HEK293_Human | 1.84383277 |
26 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.79100854 |
27 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.77980822 |
28 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.75598135 |
29 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.74027427 |
30 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.67728221 |
31 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.61013112 |
32 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.51499160 |
33 | FUS_26573619_Chip-Seq_HEK293_Human | 1.47434646 |
34 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.45616896 |
35 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.40811672 |
36 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.38770029 |
37 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.36969668 |
38 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.35943486 |
39 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.35380431 |
40 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.33273991 |
41 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.32340141 |
42 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.31583344 |
43 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.28364482 |
44 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.28147960 |
45 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.25261784 |
46 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.23344629 |
47 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.23344629 |
48 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.22654484 |
49 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.20719837 |
50 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.20623517 |
51 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.19357810 |
52 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.17899998 |
53 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.17725083 |
54 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.17361851 |
55 | P300_19829295_ChIP-Seq_ESCs_Human | 1.17118088 |
56 | GATA1_22025678_ChIP-Seq_K562_Human | 1.16611176 |
57 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.15879555 |
58 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.15163273 |
59 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.15163273 |
60 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.12416233 |
61 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.11372085 |
62 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.09065790 |
63 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.07536458 |
64 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.07413087 |
65 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.06903159 |
66 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.06245679 |
67 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.04936294 |
68 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.04890793 |
69 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.04749682 |
70 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.04239961 |
71 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.03780394 |
72 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.02848501 |
73 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.02749784 |
74 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.02317940 |
75 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.99713998 |
76 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.99394914 |
77 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.99112594 |
78 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.98155729 |
79 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.97386862 |
80 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.95191319 |
81 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.94777634 |
82 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.94567202 |
83 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.91915754 |
84 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.91475366 |
85 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.91259666 |
86 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 0.91041975 |
87 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.90091481 |
88 | AR_20517297_ChIP-Seq_VCAP_Human | 0.89641041 |
89 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.88901084 |
90 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.88074692 |
91 | GATA3_26560356_Chip-Seq_TH2_Human | 0.86645164 |
92 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.86518106 |
93 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.85494054 |
94 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.85207984 |
95 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.84731492 |
96 | ERA_21632823_ChIP-Seq_H3396_Human | 0.84659264 |
97 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.81519490 |
98 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.79935492 |
99 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.79625743 |
100 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.79284023 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0008877_abnormal_DNA_methylation | 3.55360196 |
2 | MP0008875_abnormal_xenobiotic_pharmacok | 3.19510036 |
3 | MP0003195_calcinosis | 3.10519071 |
4 | MP0004147_increased_porphyrin_level | 3.01001214 |
5 | MP0003693_abnormal_embryo_hatching | 2.98633150 |
6 | MP0001873_stomach_inflammation | 2.98026655 |
7 | MP0009379_abnormal_foot_pigmentation | 2.66689868 |
8 | MP0002102_abnormal_ear_morphology | 2.64504765 |
9 | MP0008872_abnormal_physiological_respon | 2.50783208 |
10 | MP0008058_abnormal_DNA_repair | 2.48162022 |
11 | MP0005671_abnormal_response_to | 2.30169992 |
12 | MP0003718_maternal_effect | 2.21365605 |
13 | MP0001835_abnormal_antigen_presentation | 2.17953916 |
14 | MP0002736_abnormal_nociception_after | 2.00851386 |
15 | MP0004885_abnormal_endolymph | 1.98174873 |
16 | MP0000685_abnormal_immune_system | 1.93096636 |
17 | MP0001348_abnormal_lacrimal_gland | 1.87357598 |
18 | MP0010094_abnormal_chromosome_stability | 1.86063486 |
19 | MP0004742_abnormal_vestibular_system | 1.86041119 |
20 | MP0006072_abnormal_retinal_apoptosis | 1.74993339 |
21 | MP0003950_abnormal_plasma_membrane | 1.73792549 |
22 | MP0002653_abnormal_ependyma_morphology | 1.70762047 |
23 | MP0000372_irregular_coat_pigmentation | 1.68355485 |
24 | MP0001986_abnormal_taste_sensitivity | 1.63348812 |
25 | MP0009333_abnormal_splenocyte_physiolog | 1.59824725 |
26 | MP0003136_yellow_coat_color | 1.59008530 |
27 | MP0004782_abnormal_surfactant_physiolog | 1.57738628 |
28 | MP0003186_abnormal_redox_activity | 1.56640181 |
29 | MP0005645_abnormal_hypothalamus_physiol | 1.54993446 |
30 | MP0004957_abnormal_blastocyst_morpholog | 1.51478997 |
31 | MP0001968_abnormal_touch/_nociception | 1.42684513 |
32 | MP0005387_immune_system_phenotype | 1.42553207 |
33 | MP0001790_abnormal_immune_system | 1.42553207 |
34 | MP0006292_abnormal_olfactory_placode | 1.42505883 |
35 | MP0003646_muscle_fatigue | 1.39411456 |
36 | MP0006036_abnormal_mitochondrial_physio | 1.38122114 |
37 | MP0008789_abnormal_olfactory_epithelium | 1.37041060 |
38 | MP0005551_abnormal_eye_electrophysiolog | 1.36599837 |
39 | MP0004145_abnormal_muscle_electrophysio | 1.34931079 |
40 | MP0003806_abnormal_nucleotide_metabolis | 1.34264216 |
41 | MP0009785_altered_susceptibility_to | 1.32943645 |
42 | MP0002148_abnormal_hypersensitivity_rea | 1.32346490 |
43 | MP0009745_abnormal_behavioral_response | 1.31123668 |
44 | MP0002163_abnormal_gland_morphology | 1.30247739 |
45 | MP0000569_abnormal_digit_pigmentation | 1.25490461 |
46 | MP0005085_abnormal_gallbladder_physiolo | 1.22112445 |
47 | MP0001800_abnormal_humoral_immune | 1.20945734 |
48 | MP0005365_abnormal_bile_salt | 1.19921535 |
49 | MP0003878_abnormal_ear_physiology | 1.18927268 |
50 | MP0005377_hearing/vestibular/ear_phenot | 1.18927268 |
51 | MP0009765_abnormal_xenobiotic_induced | 1.17920888 |
52 | MP0001984_abnormal_olfaction | 1.17612847 |
53 | MP0005084_abnormal_gallbladder_morpholo | 1.17178222 |
54 | MP0005310_abnormal_salivary_gland | 1.16894746 |
55 | MP0001485_abnormal_pinna_reflex | 1.03607854 |
56 | MP0005360_urolithiasis | 1.01182781 |
57 | MP0002272_abnormal_nervous_system | 0.99613760 |
58 | MP0002822_catalepsy | 0.98126263 |
59 | MP0002160_abnormal_reproductive_system | 0.97845065 |
60 | MP0001529_abnormal_vocalization | 0.97306855 |
61 | MP0005379_endocrine/exocrine_gland_phen | 0.96866831 |
62 | MP0009764_decreased_sensitivity_to | 0.96672628 |
63 | MP0005389_reproductive_system_phenotype | 0.96296354 |
64 | MP0002210_abnormal_sex_determination | 0.93187435 |
65 | MP0005174_abnormal_tail_pigmentation | 0.88968389 |
66 | MP0002277_abnormal_respiratory_mucosa | 0.87908923 |
67 | MP0008057_abnormal_DNA_replication | 0.87797204 |
68 | MP0005000_abnormal_immune_tolerance | 0.86067764 |
69 | MP0000383_abnormal_hair_follicle | 0.84843492 |
70 | MP0003786_premature_aging | 0.83970525 |
71 | MP0001501_abnormal_sleep_pattern | 0.83499928 |
72 | MP0001119_abnormal_female_reproductive | 0.83468728 |
73 | MP0001905_abnormal_dopamine_level | 0.82797310 |
74 | MP0002064_seizures | 0.81077242 |
75 | MP0000427_abnormal_hair_cycle | 0.76573477 |
76 | MP0003567_abnormal_fetal_cardiomyocyte | 0.76350298 |
77 | MP0002733_abnormal_thermal_nociception | 0.76016536 |
78 | MP0001929_abnormal_gametogenesis | 0.75475720 |
79 | MP0003111_abnormal_nucleus_morphology | 0.75020313 |
80 | MP0002138_abnormal_hepatobiliary_system | 0.74716647 |
81 | MP0005253_abnormal_eye_physiology | 0.74221786 |
82 | MP0005395_other_phenotype | 0.73919382 |
83 | MP0004215_abnormal_myocardial_fiber | 0.73506070 |
84 | MP0002723_abnormal_immune_serum | 0.72895810 |
85 | MP0003880_abnormal_central_pattern | 0.72238058 |
86 | MP0003329_amyloid_beta_deposits | 0.71801410 |
87 | MP0003077_abnormal_cell_cycle | 0.71140626 |
88 | MP0005636_abnormal_mineral_homeostasis | 0.70802135 |
89 | MP0002405_respiratory_system_inflammati | 0.70002215 |
90 | MP0001663_abnormal_digestive_system | 0.69567205 |
91 | MP0002638_abnormal_pupillary_reflex | 0.69094245 |
92 | MP0003119_abnormal_digestive_system | 0.68649612 |
93 | MP0008995_early_reproductive_senescence | 0.68639860 |
94 | MP0005499_abnormal_olfactory_system | 0.68454077 |
95 | MP0005394_taste/olfaction_phenotype | 0.68454077 |
96 | MP0004133_heterotaxia | 0.68446293 |
97 | MP0010155_abnormal_intestine_physiology | 0.65931332 |
98 | MP0005075_abnormal_melanosome_morpholog | 0.65187694 |
99 | MP0004142_abnormal_muscle_tone | 0.65057078 |
100 | MP0005319_abnormal_enzyme/_coenzyme | 0.63749788 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormality of the pons (HP:0007361) | 4.17695602 |
2 | Duplicated collecting system (HP:0000081) | 3.98098664 |
3 | Acute necrotizing encephalopathy (HP:0006965) | 3.77898303 |
4 | Abnormality of the renal collecting system (HP:0004742) | 3.65828089 |
5 | Increased CSF lactate (HP:0002490) | 3.58646926 |
6 | Large for gestational age (HP:0001520) | 3.50211435 |
7 | Mitochondrial inheritance (HP:0001427) | 3.48716698 |
8 | Hepatocellular necrosis (HP:0001404) | 3.40076798 |
9 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.33016546 |
10 | Abnormality of alanine metabolism (HP:0010916) | 3.33016546 |
11 | Hyperalaninemia (HP:0003348) | 3.33016546 |
12 | Colon cancer (HP:0003003) | 3.31218615 |
13 | Inability to walk (HP:0002540) | 3.30380961 |
14 | Hepatic necrosis (HP:0002605) | 3.27448439 |
15 | Cerebral hypomyelination (HP:0006808) | 3.26490223 |
16 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.25253942 |
17 | Acute encephalopathy (HP:0006846) | 3.12024534 |
18 | Concave nail (HP:0001598) | 3.10501866 |
19 | Hypoplasia of the pons (HP:0012110) | 3.09367278 |
20 | 3-Methylglutaconic aciduria (HP:0003535) | 3.08708248 |
21 | Abnormality of the labia minora (HP:0012880) | 3.03076799 |
22 | Molar tooth sign on MRI (HP:0002419) | 3.02673623 |
23 | Abnormality of midbrain morphology (HP:0002418) | 3.02673623 |
24 | Progressive macrocephaly (HP:0004481) | 3.01963896 |
25 | IgG deficiency (HP:0004315) | 2.87073687 |
26 | Increased serum lactate (HP:0002151) | 2.86484919 |
27 | Pancreatic cysts (HP:0001737) | 2.80052448 |
28 | Increased hepatocellular lipid droplets (HP:0006565) | 2.77613019 |
29 | Abnormal number of erythroid precursors (HP:0012131) | 2.76774819 |
30 | Birth length less than 3rd percentile (HP:0003561) | 2.76462176 |
31 | Reticulocytopenia (HP:0001896) | 2.73003178 |
32 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.63239928 |
33 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.63239928 |
34 | Increased serum pyruvate (HP:0003542) | 2.60914624 |
35 | Lipid accumulation in hepatocytes (HP:0006561) | 2.58197044 |
36 | Congenital, generalized hypertrichosis (HP:0004540) | 2.52436633 |
37 | Conical tooth (HP:0000698) | 2.47986829 |
38 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.47157456 |
39 | IgA deficiency (HP:0002720) | 2.46660798 |
40 | Confusion (HP:0001289) | 2.44357068 |
41 | Pendular nystagmus (HP:0012043) | 2.43343385 |
42 | Nephronophthisis (HP:0000090) | 2.41487797 |
43 | Cerebral edema (HP:0002181) | 2.40813967 |
44 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.39595627 |
45 | Abnormality of glycolysis (HP:0004366) | 2.33181641 |
46 | Optic disc pallor (HP:0000543) | 2.28379567 |
47 | IgM deficiency (HP:0002850) | 2.25773778 |
48 | Opisthotonus (HP:0002179) | 2.23638272 |
49 | Congenital stationary night blindness (HP:0007642) | 2.22690172 |
50 | Lactic acidosis (HP:0003128) | 2.20524511 |
51 | Absent thumb (HP:0009777) | 2.17319806 |
52 | True hermaphroditism (HP:0010459) | 2.16629797 |
53 | Ureteral duplication (HP:0000073) | 2.16251333 |
54 | Patellar aplasia (HP:0006443) | 2.12969459 |
55 | Mutism (HP:0002300) | 2.10814037 |
56 | Pancreatic fibrosis (HP:0100732) | 2.10628101 |
57 | Respiratory difficulties (HP:0002880) | 2.09765335 |
58 | Hypothermia (HP:0002045) | 2.09619018 |
59 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.08854359 |
60 | Absent/shortened dynein arms (HP:0200106) | 2.08854359 |
61 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.08659626 |
62 | CNS demyelination (HP:0007305) | 2.06203595 |
63 | Lethargy (HP:0001254) | 2.06194025 |
64 | Stomach cancer (HP:0012126) | 2.05527123 |
65 | Meckel diverticulum (HP:0002245) | 2.03863612 |
66 | Abnormality of the ileum (HP:0001549) | 2.03079853 |
67 | Partial agenesis of the corpus callosum (HP:0001338) | 2.02732595 |
68 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.01788547 |
69 | Hyperglycinuria (HP:0003108) | 2.00011449 |
70 | Abnormality of the renal cortex (HP:0011035) | 1.95385222 |
71 | Renal cortical cysts (HP:0000803) | 1.94347597 |
72 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.92471136 |
73 | Abnormality of T cell physiology (HP:0011840) | 1.92131384 |
74 | CNS hypomyelination (HP:0003429) | 1.91482825 |
75 | Decreased circulating renin level (HP:0003351) | 1.90348746 |
76 | Methylmalonic aciduria (HP:0012120) | 1.86629466 |
77 | Decreased central vision (HP:0007663) | 1.86374826 |
78 | Abnormality of the preputium (HP:0100587) | 1.84524357 |
79 | Abnormal albumin level (HP:0012116) | 1.84265869 |
80 | Hypoalbuminemia (HP:0003073) | 1.84265869 |
81 | Supernumerary spleens (HP:0009799) | 1.83830936 |
82 | Generalized aminoaciduria (HP:0002909) | 1.83685096 |
83 | Abnormality of T cells (HP:0002843) | 1.83120959 |
84 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.82472472 |
85 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.82472472 |
86 | Bile duct proliferation (HP:0001408) | 1.82432326 |
87 | Abnormal biliary tract physiology (HP:0012439) | 1.82432326 |
88 | Respiratory failure (HP:0002878) | 1.81155365 |
89 | Exercise intolerance (HP:0003546) | 1.80786401 |
90 | Type II lissencephaly (HP:0007260) | 1.80636424 |
91 | Clubbing of toes (HP:0100760) | 1.79888863 |
92 | Renal Fanconi syndrome (HP:0001994) | 1.78941071 |
93 | Increased intramyocellular lipid droplets (HP:0012240) | 1.78479334 |
94 | Palpebral edema (HP:0100540) | 1.78312433 |
95 | Abnormality of the renal medulla (HP:0100957) | 1.78243689 |
96 | Furrowed tongue (HP:0000221) | 1.78229885 |
97 | Chromsome breakage (HP:0040012) | 1.78192948 |
98 | Morphological abnormality of the inner ear (HP:0011390) | 1.77218439 |
99 | Bronchiectasis (HP:0002110) | 1.75934528 |
100 | Azoospermia (HP:0000027) | 1.72377280 |
Rank | Gene Set | Z-score |
---|---|---|
1 | VRK2 | 3.70430148 |
2 | TSSK6 | 3.61835445 |
3 | ADRBK2 | 3.54226882 |
4 | ZAK | 3.53425270 |
5 | PBK | 3.14452924 |
6 | TLK1 | 2.97133730 |
7 | BUB1 | 2.93238780 |
8 | EIF2AK3 | 2.77779155 |
9 | EIF2AK1 | 2.77425601 |
10 | VRK1 | 2.68517087 |
11 | TRIM28 | 2.54039682 |
12 | NUAK1 | 2.17537151 |
13 | TNIK | 2.07770174 |
14 | MST4 | 2.06362928 |
15 | ALK | 1.83423207 |
16 | NME1 | 1.80488810 |
17 | WNK3 | 1.73340282 |
18 | PASK | 1.70179773 |
19 | TXK | 1.65270749 |
20 | NEK1 | 1.63121806 |
21 | PDK2 | 1.59300288 |
22 | ACVR1B | 1.58561271 |
23 | PLK4 | 1.58488142 |
24 | DAPK2 | 1.58457280 |
25 | PLK3 | 1.57543614 |
26 | BMPR1B | 1.56309211 |
27 | MKNK1 | 1.53715943 |
28 | BCKDK | 1.53240762 |
29 | GRK1 | 1.46086875 |
30 | TGFBR1 | 1.40349523 |
31 | STK16 | 1.39277526 |
32 | MAP2K2 | 1.37655946 |
33 | MAP2K6 | 1.27256715 |
34 | WNK4 | 1.17563046 |
35 | DYRK2 | 1.14933701 |
36 | CCNB1 | 1.11714175 |
37 | NLK | 1.11105141 |
38 | MKNK2 | 1.10751252 |
39 | FRK | 1.08540267 |
40 | PINK1 | 1.06311791 |
41 | CAMKK2 | 1.04509833 |
42 | ADRBK1 | 0.95384704 |
43 | CDC7 | 0.90896350 |
44 | EIF2AK2 | 0.88804430 |
45 | ITK | 0.86691723 |
46 | IKBKB | 0.82559792 |
47 | MAPK13 | 0.81707924 |
48 | NEK6 | 0.81506172 |
49 | PKN1 | 0.80007768 |
50 | PNCK | 0.79964091 |
51 | PLK2 | 0.77823767 |
52 | MELK | 0.76593133 |
53 | GRK5 | 0.73723372 |
54 | BRSK2 | 0.73339124 |
55 | TIE1 | 0.73234035 |
56 | MAP2K7 | 0.69711281 |
57 | CDK8 | 0.67010767 |
58 | MAP4K2 | 0.66730485 |
59 | KDR | 0.65700133 |
60 | RPS6KA5 | 0.65352523 |
61 | INSRR | 0.64873000 |
62 | MAPKAPK3 | 0.64842415 |
63 | OXSR1 | 0.64588374 |
64 | MAP4K1 | 0.64131406 |
65 | TTK | 0.63297062 |
66 | PLK1 | 0.61119396 |
67 | WEE1 | 0.59941775 |
68 | PRKCQ | 0.58943349 |
69 | ERBB4 | 0.57715382 |
70 | CDK3 | 0.57087955 |
71 | STK4 | 0.56199395 |
72 | AURKB | 0.55418720 |
73 | SRPK1 | 0.54956072 |
74 | ATR | 0.53458662 |
75 | FLT3 | 0.52582630 |
76 | IRAK4 | 0.46954291 |
77 | FGFR1 | 0.43394687 |
78 | PHKG2 | 0.40991035 |
79 | PHKG1 | 0.40991035 |
80 | PIK3CG | 0.40944004 |
81 | PIK3CA | 0.40332116 |
82 | BRSK1 | 0.40046552 |
83 | CDK4 | 0.39773719 |
84 | PRKCI | 0.39075247 |
85 | MAP3K4 | 0.38334983 |
86 | CSNK2A1 | 0.37108725 |
87 | MAPKAPK5 | 0.36554526 |
88 | MAP3K5 | 0.36154331 |
89 | IKBKE | 0.33770898 |
90 | TAF1 | 0.32923682 |
91 | TEC | 0.32245483 |
92 | PIM1 | 0.32103929 |
93 | STK11 | 0.30749633 |
94 | GRK7 | 0.30208991 |
95 | BMPR2 | 0.29097242 |
96 | PRKCG | 0.28535998 |
97 | TAOK3 | 0.27988954 |
98 | STK39 | 0.27540799 |
99 | AURKA | 0.27493433 |
100 | CHUK | 0.26759377 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 4.64269023 |
2 | Ribosome_Homo sapiens_hsa03010 | 2.72347000 |
3 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.66401225 |
4 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.64010436 |
5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.51929078 |
6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.42276547 |
7 | RNA polymerase_Homo sapiens_hsa03020 | 2.37672890 |
8 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.28343800 |
9 | Homologous recombination_Homo sapiens_hsa03440 | 2.22828214 |
10 | Asthma_Homo sapiens_hsa05310 | 2.07470320 |
11 | Protein export_Homo sapiens_hsa03060 | 2.05374179 |
12 | Parkinsons disease_Homo sapiens_hsa05012 | 2.03155979 |
13 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.99431569 |
14 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.96325426 |
15 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.93768029 |
16 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.92506005 |
17 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.91023681 |
18 | RNA degradation_Homo sapiens_hsa03018 | 1.73717562 |
19 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.73086695 |
20 | DNA replication_Homo sapiens_hsa03030 | 1.71115420 |
21 | Allograft rejection_Homo sapiens_hsa05330 | 1.66202962 |
22 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.57149946 |
23 | Basal transcription factors_Homo sapiens_hsa03022 | 1.46621858 |
24 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.43489906 |
25 | Mismatch repair_Homo sapiens_hsa03430 | 1.38634786 |
26 | Huntingtons disease_Homo sapiens_hsa05016 | 1.37664346 |
27 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.36883752 |
28 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.35307548 |
29 | Base excision repair_Homo sapiens_hsa03410 | 1.34150042 |
30 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.34147745 |
31 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.33454564 |
32 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.30056238 |
33 | Spliceosome_Homo sapiens_hsa03040 | 1.29173455 |
34 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.24349887 |
35 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.22700621 |
36 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.20756977 |
37 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.20444167 |
38 | RNA transport_Homo sapiens_hsa03013 | 1.19589513 |
39 | Peroxisome_Homo sapiens_hsa04146 | 1.19526249 |
40 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.18752446 |
41 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.17992860 |
42 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.15104218 |
43 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.14642803 |
44 | Alzheimers disease_Homo sapiens_hsa05010 | 1.13086381 |
45 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.11897035 |
46 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.11835239 |
47 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.10566103 |
48 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.07466162 |
49 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.03373153 |
50 | Purine metabolism_Homo sapiens_hsa00230 | 1.02182285 |
51 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.98968974 |
52 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.97599333 |
53 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.97545025 |
54 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.94168377 |
55 | Phototransduction_Homo sapiens_hsa04744 | 0.93943365 |
56 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.93811135 |
57 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.92757527 |
58 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.89247831 |
59 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.88871746 |
60 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.85339487 |
61 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.84070571 |
62 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.83477412 |
63 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.81614709 |
64 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.80917454 |
65 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.80460719 |
66 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.74112686 |
67 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.73699185 |
68 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.71498517 |
69 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.71254509 |
70 | Retinol metabolism_Homo sapiens_hsa00830 | 0.70182664 |
71 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.68029301 |
72 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.66781559 |
73 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.63940145 |
74 | Metabolic pathways_Homo sapiens_hsa01100 | 0.62396230 |
75 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.61817212 |
76 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.61391673 |
77 | Nicotine addiction_Homo sapiens_hsa05033 | 0.60969176 |
78 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.60826003 |
79 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.59532520 |
80 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.55329564 |
81 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.55215617 |
82 | ABC transporters_Homo sapiens_hsa02010 | 0.50514879 |
83 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.49262919 |
84 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.41801994 |
85 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.41665109 |
86 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.40753388 |
87 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.39771404 |
88 | Olfactory transduction_Homo sapiens_hsa04740 | 0.39031574 |
89 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.38893838 |
90 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.38152150 |
91 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.37633084 |
92 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.37016264 |
93 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.36824192 |
94 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.36394051 |
95 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.35367242 |
96 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.33915592 |
97 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.33185072 |
98 | Histidine metabolism_Homo sapiens_hsa00340 | 0.33063746 |
99 | Cell cycle_Homo sapiens_hsa04110 | 0.32748763 |
100 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.31533223 |