HNRNPA1P32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.61394490
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.41244551
3ATP synthesis coupled proton transport (GO:0015986)6.41244551
4DNA deamination (GO:0045006)5.39734171
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.26861140
6nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.54914945
7exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.49105819
8chaperone-mediated protein transport (GO:0072321)4.16717987
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.13419098
10rRNA modification (GO:0000154)4.03087204
11kynurenine metabolic process (GO:0070189)3.90664912
12electron transport chain (GO:0022900)3.87182605
13respiratory electron transport chain (GO:0022904)3.86173964
14ATP biosynthetic process (GO:0006754)3.85279411
15protein complex biogenesis (GO:0070271)3.79984556
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.78516844
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74713830
18purine nucleobase biosynthetic process (GO:0009113)3.68682571
19mitochondrial respiratory chain complex assembly (GO:0033108)3.56990290
20positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.55776234
21positive regulation of prostaglandin secretion (GO:0032308)3.54015097
22ribosomal large subunit biogenesis (GO:0042273)3.52893765
23regulation of cellular amino acid metabolic process (GO:0006521)3.51631989
24inner mitochondrial membrane organization (GO:0007007)3.50569053
25regulation of chronic inflammatory response (GO:0002676)3.46651844
26regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.43058001
27purine-containing compound salvage (GO:0043101)3.42642086
28purine nucleoside triphosphate biosynthetic process (GO:0009145)3.41038143
29negative regulation of ligase activity (GO:0051352)3.40039038
30negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.40039038
31purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.38349290
32negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.36426927
33protein neddylation (GO:0045116)3.35978920
34purine nucleotide salvage (GO:0032261)3.32901293
35DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.30852525
36proteasome assembly (GO:0043248)3.29900271
37signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.25716389
38signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.25716389
39signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.25716389
40nucleobase biosynthetic process (GO:0046112)3.23673286
41pseudouridine synthesis (GO:0001522)3.21404051
42signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.20820842
43intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.20820842
44respiratory chain complex IV assembly (GO:0008535)3.18927283
45cytidine deamination (GO:0009972)3.18641747
46cytidine metabolic process (GO:0046087)3.18641747
47cytidine catabolic process (GO:0006216)3.18641747
48cytochrome complex assembly (GO:0017004)3.18478806
49anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.13913734
50negative regulation of heart rate (GO:0010459)3.12632187
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.12109241
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.12109241
53NADH dehydrogenase complex assembly (GO:0010257)3.12109241
54signal transduction involved in DNA integrity checkpoint (GO:0072401)3.09651856
55signal transduction involved in DNA damage checkpoint (GO:0072422)3.09651856
56preassembly of GPI anchor in ER membrane (GO:0016254)3.08634624
57protein-cofactor linkage (GO:0018065)3.07168603
58purine nucleoside monophosphate biosynthetic process (GO:0009127)3.07078612
59purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.07078612
60signal transduction involved in cell cycle checkpoint (GO:0072395)3.06902883
61rRNA methylation (GO:0031167)3.05527435
62tryptophan catabolic process (GO:0006569)3.05097134
63indole-containing compound catabolic process (GO:0042436)3.05097134
64indolalkylamine catabolic process (GO:0046218)3.05097134
65regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.04815337
66regulation of mitotic spindle checkpoint (GO:1903504)3.04815337
67transcription elongation from RNA polymerase III promoter (GO:0006385)2.99795449
68termination of RNA polymerase III transcription (GO:0006386)2.99795449
69regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.99629858
70IMP biosynthetic process (GO:0006188)2.96286047
71positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.91889403
72positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.91058388
73positive regulation of protein homodimerization activity (GO:0090073)2.90935425
74somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.89791977
75somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.89791977
76isotype switching (GO:0045190)2.89791977
77neuronal action potential propagation (GO:0019227)2.88762783
78ribonucleoside triphosphate biosynthetic process (GO:0009201)2.86172580
79positive regulation of ligase activity (GO:0051351)2.85888357
80DNA double-strand break processing (GO:0000729)2.84538090
81organelle disassembly (GO:1903008)2.84087457
82hydrogen ion transmembrane transport (GO:1902600)2.82690811
83mast cell degranulation (GO:0043303)2.82660206
84mast cell activation involved in immune response (GO:0002279)2.82660206
85ribosomal small subunit assembly (GO:0000028)2.81940278
86regulation of prostaglandin secretion (GO:0032306)2.80843905
87intracellular protein transmembrane import (GO:0044743)2.76694988
88DNA catabolic process, exonucleolytic (GO:0000738)2.73029464
89kinetochore assembly (GO:0051382)2.71917650
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.71809459
91GMP metabolic process (GO:0046037)2.70573059
92regulation of cellular amine metabolic process (GO:0033238)2.69180899
93regulation of mitochondrial translation (GO:0070129)2.68953927
94translation (GO:0006412)2.67840869
95piRNA metabolic process (GO:0034587)2.65562603
96protein deneddylation (GO:0000338)2.64664234
97SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.62998534
98tryptophan metabolic process (GO:0006568)2.60577841
99pyrimidine ribonucleoside catabolic process (GO:0046133)2.60492933
100protein peptidyl-prolyl isomerization (GO:0000413)2.59689372

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.54450716
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.19455340
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.81383200
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.77533878
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.02606575
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.97916606
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.81760685
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.77017370
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60076704
10VDR_23849224_ChIP-Seq_CD4+_Human2.53536697
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.51710041
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48995178
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.46482588
14ELK1_19687146_ChIP-ChIP_HELA_Human2.44707507
15VDR_22108803_ChIP-Seq_LS180_Human2.29584984
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27521488
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.24734812
18E2F7_22180533_ChIP-Seq_HELA_Human2.20484912
19TAF15_26573619_Chip-Seq_HEK293_Human2.18129056
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17778133
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14623085
22ZNF274_21170338_ChIP-Seq_K562_Hela2.06178591
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99813479
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.98011600
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92935604
26FOXP3_21729870_ChIP-Seq_TREG_Human1.92569608
27EWS_26573619_Chip-Seq_HEK293_Human1.92343250
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90758358
29MYC_18940864_ChIP-ChIP_HL60_Human1.89810443
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78768548
31FUS_26573619_Chip-Seq_HEK293_Human1.72023482
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71685280
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67954397
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64125478
35IGF1R_20145208_ChIP-Seq_DFB_Human1.63269918
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.55074245
37IRF1_19129219_ChIP-ChIP_H3396_Human1.55039910
38TP53_22573176_ChIP-Seq_HFKS_Human1.53511182
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50836791
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50675370
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50324709
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46093456
43DCP1A_22483619_ChIP-Seq_HELA_Human1.43792610
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41993619
45P300_19829295_ChIP-Seq_ESCs_Human1.40451737
46TTF2_22483619_ChIP-Seq_HELA_Human1.39157788
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38577690
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35336915
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33911132
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32028483
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30983709
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30183599
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.30183599
54NANOG_19829295_ChIP-Seq_ESCs_Human1.27648348
55SOX2_19829295_ChIP-Seq_ESCs_Human1.27648348
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27347972
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26728814
58GATA3_26560356_Chip-Seq_TH2_Human1.26609174
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26416025
60IRF8_21731497_ChIP-ChIP_J774_Mouse1.25101710
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.24957640
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23208010
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22850440
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21816326
65EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19896003
66AR_20517297_ChIP-Seq_VCAP_Human1.17337672
67ER_23166858_ChIP-Seq_MCF-7_Human1.16906052
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15645010
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14791257
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09958142
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09622965
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09128547
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08852140
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06120732
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06024151
76ERG_20517297_ChIP-Seq_VCAP_Human1.05524572
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.04295869
78STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03950286
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03720251
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03345199
81GABP_19822575_ChIP-Seq_HepG2_Human1.02008557
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98927439
83FOXH1_21741376_ChIP-Seq_EPCs_Human0.98193186
84IRF8_22096565_ChIP-ChIP_GC-B_Human0.96715823
85EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95770256
86GATA3_26560356_Chip-Seq_TH1_Human0.95656012
87TCF4_22108803_ChIP-Seq_LS180_Human0.95454760
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94814001
89MYB_26560356_Chip-Seq_TH2_Human0.94230389
90THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92267093
91EZH2_27294783_Chip-Seq_NPCs_Mouse0.91730248
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91379388
93GATA3_21878914_ChIP-Seq_MCF-7_Human0.91058738
94E2F1_21310950_ChIP-Seq_MCF-7_Human0.90954620
95CBP_20019798_ChIP-Seq_JUKART_Human0.90392694
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90392694
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89980268
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88358316
99NCOR_22424771_ChIP-Seq_293T_Human0.88024526
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.86085988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.37704333
2MP0008058_abnormal_DNA_repair3.07420586
3MP0005671_abnormal_response_to2.99528554
4MP0006072_abnormal_retinal_apoptosis2.95220088
5MP0001835_abnormal_antigen_presentation2.90710124
6MP0003806_abnormal_nucleotide_metabolis2.89479692
7MP0008875_abnormal_xenobiotic_pharmacok2.82221411
8MP0005084_abnormal_gallbladder_morpholo2.62318703
9MP0004147_increased_porphyrin_level2.45725563
10MP0003195_calcinosis2.24106354
11MP0002138_abnormal_hepatobiliary_system2.22476412
12MP0002166_altered_tumor_susceptibility2.22398657
13MP0006292_abnormal_olfactory_placode2.17571924
14MP0001348_abnormal_lacrimal_gland2.11875649
15MP0010094_abnormal_chromosome_stability2.08744263
16MP0000372_irregular_coat_pigmentation2.07645262
17MP0002006_tumorigenesis1.93754119
18MP0002736_abnormal_nociception_after1.88691655
19MP0009697_abnormal_copulation1.79493795
20MP0002102_abnormal_ear_morphology1.77285689
21MP0001873_stomach_inflammation1.69672769
22MP0008872_abnormal_physiological_respon1.69589435
23MP0005645_abnormal_hypothalamus_physiol1.66585387
24MP0001968_abnormal_touch/_nociception1.65844306
25MP0000685_abnormal_immune_system1.62135442
26MP0003693_abnormal_embryo_hatching1.55411801
27MP0002254_reproductive_system_inflammat1.52989649
28MP0003786_premature_aging1.52470716
29MP0005253_abnormal_eye_physiology1.51534331
30MP0006035_abnormal_mitochondrial_morpho1.51208030
31MP0002876_abnormal_thyroid_physiology1.51089700
32MP0002938_white_spotting1.47210898
33MP0006036_abnormal_mitochondrial_physio1.46758293
34MP0001800_abnormal_humoral_immune1.45114473
35MP0005551_abnormal_eye_electrophysiolog1.44938470
36MP0001919_abnormal_reproductive_system1.36235855
37MP0005387_immune_system_phenotype1.35687547
38MP0001790_abnormal_immune_system1.35687547
39MP0004957_abnormal_blastocyst_morpholog1.34462319
40MP0009333_abnormal_splenocyte_physiolog1.33740920
41MP0009785_altered_susceptibility_to1.31067056
42MP0003763_abnormal_thymus_physiology1.28817828
43MP0005389_reproductive_system_phenotype1.27609530
44MP0003252_abnormal_bile_duct1.25811660
45MP0002160_abnormal_reproductive_system1.19166194
46MP0003787_abnormal_imprinting1.17226725
47MP0001293_anophthalmia1.16711541
48MP0001501_abnormal_sleep_pattern1.16107197
49MP0002090_abnormal_vision1.11724608
50MP0001986_abnormal_taste_sensitivity1.10952595
51MP0001984_abnormal_olfaction1.09760196
52MP0005085_abnormal_gallbladder_physiolo1.08705426
53MP0006082_CNS_inflammation1.05944886
54MP0009745_abnormal_behavioral_response1.05339314
55MP0003880_abnormal_central_pattern1.03793918
56MP0003111_abnormal_nucleus_morphology1.03697670
57MP0004142_abnormal_muscle_tone1.02293426
58MP0002452_abnormal_antigen_presenting1.02287926
59MP0002277_abnormal_respiratory_mucosa1.02229604
60MP0003718_maternal_effect1.01567858
61MP0003866_abnormal_defecation1.01341796
62MP0002723_abnormal_immune_serum1.00717092
63MP0001905_abnormal_dopamine_level1.00078813
64MP0001929_abnormal_gametogenesis0.99555239
65MP0006276_abnormal_autonomic_nervous0.99374103
66MP0005000_abnormal_immune_tolerance0.99197398
67MP0003077_abnormal_cell_cycle0.98150534
68MP0001486_abnormal_startle_reflex0.96597195
69MP0002272_abnormal_nervous_system0.95743622
70MP0002148_abnormal_hypersensitivity_rea0.95719264
71MP0001819_abnormal_immune_cell0.95635845
72MP0001764_abnormal_homeostasis0.95289764
73MP0002837_dystrophic_cardiac_calcinosis0.93650098
74MP0001346_abnormal_lacrimal_gland0.91891805
75MP0005167_abnormal_blood-brain_barrier0.91459783
76MP0002420_abnormal_adaptive_immunity0.91024292
77MP0002210_abnormal_sex_determination0.90898576
78MP0008995_early_reproductive_senescence0.90134152
79MP0003186_abnormal_redox_activity0.89571264
80MP0008007_abnormal_cellular_replicative0.87839167
81MP0009764_decreased_sensitivity_to0.85878308
82MP0009046_muscle_twitch0.85361716
83MP0003646_muscle_fatigue0.83524070
84MP0005646_abnormal_pituitary_gland0.82693362
85MP0005410_abnormal_fertilization0.82388737
86MP0003724_increased_susceptibility_to0.80971100
87MP0002933_joint_inflammation0.80265498
88MP0002733_abnormal_thermal_nociception0.80044708
89MP0005310_abnormal_salivary_gland0.79053306
90MP0003567_abnormal_fetal_cardiomyocyte0.78580536
91MP0000653_abnormal_sex_gland0.77908251
92MP0010155_abnormal_intestine_physiology0.77875537
93MP0002735_abnormal_chemical_nociception0.76953122
94MP0001502_abnormal_circadian_rhythm0.76524351
95MP0003436_decreased_susceptibility_to0.74997826
96MP0002751_abnormal_autonomic_nervous0.74812058
97MP0001970_abnormal_pain_threshold0.74798562
98MP0005075_abnormal_melanosome_morpholog0.74203656
99MP0003137_abnormal_impulse_conducting0.73882409
100MP0003698_abnormal_male_reproductive0.71892312

Predicted human phenotypes

RankGene SetZ-score
1Congenital, generalized hypertrichosis (HP:0004540)4.49991652
2Testicular atrophy (HP:0000029)4.39748429
3Acute necrotizing encephalopathy (HP:0006965)4.12069272
4Lipid accumulation in hepatocytes (HP:0006561)4.10909223
5Mitochondrial inheritance (HP:0001427)3.87749006
6Abnormal mitochondria in muscle tissue (HP:0008316)3.72319475
7Increased hepatocellular lipid droplets (HP:0006565)3.69496705
8Increased CSF lactate (HP:0002490)3.68432525
93-Methylglutaconic aciduria (HP:0003535)3.63338372
10Progressive macrocephaly (HP:0004481)3.46650191
11Acute encephalopathy (HP:0006846)3.46592290
12IgG deficiency (HP:0004315)3.25247757
13Methylmalonic acidemia (HP:0002912)3.15710363
14Autoimmune thrombocytopenia (HP:0001973)3.06475278
15Hepatocellular necrosis (HP:0001404)2.87627238
16Cerebral edema (HP:0002181)2.83877406
17Autoimmune hemolytic anemia (HP:0001890)2.82039978
18Increased serum lactate (HP:0002151)2.66719896
19Hepatic necrosis (HP:0002605)2.66394974
20Abolished electroretinogram (ERG) (HP:0000550)2.57011940
21Increased muscle lipid content (HP:0009058)2.52130637
22Optic disc pallor (HP:0000543)2.49943998
23Increased intramyocellular lipid droplets (HP:0012240)2.48868453
24Renal Fanconi syndrome (HP:0001994)2.48774529
25Congenital stationary night blindness (HP:0007642)2.45969192
26Supernumerary spleens (HP:0009799)2.43013266
27Type 2 muscle fiber atrophy (HP:0003554)2.40333745
28Hypoplasia of the pons (HP:0012110)2.37751113
29Pancreatic cysts (HP:0001737)2.37058705
30Methylmalonic aciduria (HP:0012120)2.35277449
31B lymphocytopenia (HP:0010976)2.34876918
32Hypomagnesemia (HP:0002917)2.34501358
33Exertional dyspnea (HP:0002875)2.33183559
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.31644178
35Attenuation of retinal blood vessels (HP:0007843)2.31402305
36Lactic acidosis (HP:0003128)2.30509838
37Abnormality of the pons (HP:0007361)2.30291812
38Megaloblastic anemia (HP:0001889)2.29488815
39Pancreatic fibrosis (HP:0100732)2.24248428
40Opisthotonus (HP:0002179)2.23564695
41Nephronophthisis (HP:0000090)2.22198871
42Tetraparesis (HP:0002273)2.21686356
43Abnormality of B cell number (HP:0010975)2.15331469
44Dyschromatopsia (HP:0007641)2.14167184
45Prostate neoplasm (HP:0100787)2.14121417
46Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.13135260
47Abnormal rod and cone electroretinograms (HP:0008323)2.11839477
48Lethargy (HP:0001254)2.11655602
49Macrocytic anemia (HP:0001972)2.10999163
50Molar tooth sign on MRI (HP:0002419)2.10911208
51Abnormality of midbrain morphology (HP:0002418)2.10911208
52Chronic sinusitis (HP:0011109)2.09479485
53Hyperglycinuria (HP:0003108)2.07363685
54Hyperinsulinemic hypoglycemia (HP:0000825)2.06064302
55Stomatitis (HP:0010280)2.05490119
56Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04737835
57Large for gestational age (HP:0001520)2.04613603
58Abnormality of the prostate (HP:0008775)2.03408424
59Abnormality of T cells (HP:0002843)2.03233761
60Abnormality of T cell physiology (HP:0011840)1.98859712
61Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98059670
62Ketoacidosis (HP:0001993)1.95171555
63Abnormality of the vitamin B12 metabolism (HP:0004341)1.94837960
64Exercise intolerance (HP:0003546)1.94587278
65Respiratory failure (HP:0002878)1.94530888
66Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93228539
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93228539
68Adrenal hypoplasia (HP:0000835)1.91597834
69Muscle fiber atrophy (HP:0100295)1.90068683
70Abnormality of magnesium homeostasis (HP:0004921)1.87846316
71Abnormality of vitamin B metabolism (HP:0004340)1.87287645
72Abnormality of methionine metabolism (HP:0010901)1.86250687
73Parakeratosis (HP:0001036)1.85475412
74Abnormality of the labia minora (HP:0012880)1.84934325
75Abnormal spermatogenesis (HP:0008669)1.84716403
76Abnormality of macular pigmentation (HP:0008002)1.84540373
77Azoospermia (HP:0000027)1.84310226
78Abnormality of the ileum (HP:0001549)1.83674900
79Amniotic constriction ring (HP:0009775)1.82781864
80Abnormality of placental membranes (HP:0011409)1.82781864
81Meckel diverticulum (HP:0002245)1.81811104
82Cerebral palsy (HP:0100021)1.80848949
83Increased neuronal autofluorescent lipopigment (HP:0002074)1.79315902
84Pancytopenia (HP:0001876)1.78709409
85Chronic mucocutaneous candidiasis (HP:0002728)1.76768504
86Recurrent cutaneous fungal infections (HP:0011370)1.76768504
87Abnormality of eosinophils (HP:0001879)1.75753579
88True hermaphroditism (HP:0010459)1.74743686
89Severe combined immunodeficiency (HP:0004430)1.74373108
90Abnormality of the renal medulla (HP:0100957)1.74114247
91Abnormality of serine family amino acid metabolism (HP:0010894)1.73823836
92Abnormality of glycine metabolism (HP:0010895)1.73823836
93Elevated erythrocyte sedimentation rate (HP:0003565)1.69589976
94Congenital ichthyosiform erythroderma (HP:0007431)1.69332090
95Visual hallucinations (HP:0002367)1.69252853
96Absent rod-and cone-mediated responses on ERG (HP:0007688)1.68648463
97Hypoproteinemia (HP:0003075)1.67343774
98Constricted visual fields (HP:0001133)1.66720207
99Leukodystrophy (HP:0002415)1.66069505
100Erythroderma (HP:0001019)1.65564937

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.44113519
2TSSK63.23929755
3NEK12.96960930
4NUAK12.92311610
5ZAK2.87859517
6TXK2.85990595
7TLK12.73017052
8MAP3K122.56170496
9MAP4K22.51087897
10BUB12.37296709
11EIF2AK32.28772389
12ADRBK22.15039545
13VRK22.09155212
14KIT2.08445621
15INSRR2.06051095
16MST41.89541973
17VRK11.89209160
18PBK1.80731848
19MKNK11.80555627
20EIF2AK11.77946180
21PLK31.68021195
22GRK11.65118486
23PLK41.57380542
24WNK31.54576030
25BMPR21.50325099
26FRK1.44358301
27MAP4K11.25049679
28WNK41.24430037
29EIF2AK21.08524692
30SRPK11.06916776
31ERBB31.06818356
32PLK21.06604167
33BCKDK1.06152085
34TRIM281.03650881
35STK391.03113896
36MKNK21.01322043
37WEE10.99103487
38GRK60.98915125
39CDC70.98898508
40PASK0.92959458
41OXSR10.90841709
42IKBKE0.87444220
43MATK0.86653647
44SYK0.86526168
45MYLK0.85764941
46TIE10.85319751
47FES0.85093448
48TEC0.81706172
49IKBKB0.81496689
50PNCK0.76897162
51CDK190.76014477
52BMPR1B0.75349598
53MAPK150.75271767
54PLK10.69194636
55AURKB0.67891054
56TAF10.65953669
57TGFBR10.62229288
58PTK2B0.62210230
59PINK10.61991609
60SCYL20.61234217
61STK160.58447253
62RPS6KA50.58174708
63TNIK0.58065967
64TTK0.54055377
65KDR0.53763406
66LYN0.51972401
67ALK0.51679295
68ITK0.49020584
69DAPK10.48850992
70ADRBK10.48504896
71FLT30.48047814
72CSNK2A10.47346632
73CAMK2A0.46882514
74PHKG20.44583792
75PHKG10.44583792
76RPS6KA40.43900508
77PIK3CG0.43202316
78MAP2K60.41720672
79PRKG10.41322926
80IGF1R0.41159346
81MAP2K20.39886802
82CSNK1G20.38983164
83CSNK1A10.38669286
84CCNB10.38600869
85DYRK20.38575398
86MAP3K40.38309696
87BRSK20.38161022
88JAK30.37602993
89GRK50.36635423
90NEK60.36056488
91CSNK2A20.35453314
92CAMK2D0.34844848
93PRKCQ0.34834065
94PRKCG0.34461151
95CAMKK20.34407702
96NLK0.33990196
97PRKCE0.33949974
98BTK0.33169149
99LCK0.33075666
100PRKACA0.31813634

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.61979783
2Oxidative phosphorylation_Homo sapiens_hsa001903.45582696
3Asthma_Homo sapiens_hsa053103.13237650
4Parkinsons disease_Homo sapiens_hsa050123.07821233
5Ribosome_Homo sapiens_hsa030103.00492173
6Protein export_Homo sapiens_hsa030602.86525423
7Caffeine metabolism_Homo sapiens_hsa002322.34931778
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.30161335
9RNA polymerase_Homo sapiens_hsa030202.27413493
10Homologous recombination_Homo sapiens_hsa034402.11261520
11Alzheimers disease_Homo sapiens_hsa050102.06198345
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05295696
13Allograft rejection_Homo sapiens_hsa053302.03069931
14Huntingtons disease_Homo sapiens_hsa050162.01961980
15Mismatch repair_Homo sapiens_hsa034301.93132571
16Autoimmune thyroid disease_Homo sapiens_hsa053201.91877223
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80822816
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70832680
19RNA degradation_Homo sapiens_hsa030181.70281330
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61283862
21DNA replication_Homo sapiens_hsa030301.61230983
22Propanoate metabolism_Homo sapiens_hsa006401.61144863
23One carbon pool by folate_Homo sapiens_hsa006701.60553666
24Fanconi anemia pathway_Homo sapiens_hsa034601.55449997
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53372002
26Primary immunodeficiency_Homo sapiens_hsa053401.52059721
27Spliceosome_Homo sapiens_hsa030401.51993502
28Basal transcription factors_Homo sapiens_hsa030221.51857786
29Nucleotide excision repair_Homo sapiens_hsa034201.44525737
30Type I diabetes mellitus_Homo sapiens_hsa049401.42132731
31Cardiac muscle contraction_Homo sapiens_hsa042601.31708238
32Phototransduction_Homo sapiens_hsa047441.31296829
33Non-homologous end-joining_Homo sapiens_hsa034501.28556587
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25586371
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22732052
36Graft-versus-host disease_Homo sapiens_hsa053321.20079649
37Purine metabolism_Homo sapiens_hsa002301.17598921
38Base excision repair_Homo sapiens_hsa034101.12697085
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12362942
40Pyrimidine metabolism_Homo sapiens_hsa002401.07341967
41Antigen processing and presentation_Homo sapiens_hsa046121.06585976
42RNA transport_Homo sapiens_hsa030131.03690746
43Ether lipid metabolism_Homo sapiens_hsa005651.01936158
44Tryptophan metabolism_Homo sapiens_hsa003801.01860851
45Linoleic acid metabolism_Homo sapiens_hsa005910.98819549
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96516284
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.94405947
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93302057
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.87934416
50Peroxisome_Homo sapiens_hsa041460.87443100
51Butanoate metabolism_Homo sapiens_hsa006500.86707652
52Steroid biosynthesis_Homo sapiens_hsa001000.82227364
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76824020
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75712501
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.75661475
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73766131
57Nitrogen metabolism_Homo sapiens_hsa009100.73122456
58Folate biosynthesis_Homo sapiens_hsa007900.73027130
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71803826
60Glutathione metabolism_Homo sapiens_hsa004800.69450845
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65731919
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65691766
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65422391
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.64758015
65Regulation of autophagy_Homo sapiens_hsa041400.62989820
66Arachidonic acid metabolism_Homo sapiens_hsa005900.60580897
67Chemical carcinogenesis_Homo sapiens_hsa052040.60313502
68Metabolic pathways_Homo sapiens_hsa011000.59627380
69Rheumatoid arthritis_Homo sapiens_hsa053230.59379628
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57593469
71Fatty acid elongation_Homo sapiens_hsa000620.57101621
72Systemic lupus erythematosus_Homo sapiens_hsa053220.56650107
73Olfactory transduction_Homo sapiens_hsa047400.50408414
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50132369
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44035656
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43610787
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42879487
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42788197
79Selenocompound metabolism_Homo sapiens_hsa004500.41639645
80Nicotine addiction_Homo sapiens_hsa050330.41314985
81Fatty acid degradation_Homo sapiens_hsa000710.39180108
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.37132730
83Fat digestion and absorption_Homo sapiens_hsa049750.34101672
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33785383
85Mineral absorption_Homo sapiens_hsa049780.33235744
86Ovarian steroidogenesis_Homo sapiens_hsa049130.32797205
87Morphine addiction_Homo sapiens_hsa050320.30289953
88Hematopoietic cell lineage_Homo sapiens_hsa046400.30005539
89Cell cycle_Homo sapiens_hsa041100.29630360
90Oocyte meiosis_Homo sapiens_hsa041140.27266683
91Pyruvate metabolism_Homo sapiens_hsa006200.27206177
92Retinol metabolism_Homo sapiens_hsa008300.26289183
93Epstein-Barr virus infection_Homo sapiens_hsa051690.24894370
94Sulfur metabolism_Homo sapiens_hsa009200.24294122
95Vitamin digestion and absorption_Homo sapiens_hsa049770.22868188
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21775804
97Salivary secretion_Homo sapiens_hsa049700.21063158
98Taste transduction_Homo sapiens_hsa047420.20791031
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.20481968
100GABAergic synapse_Homo sapiens_hsa047270.18723415

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