

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.61394490 |
| 2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 6.41244551 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 6.41244551 |
| 4 | DNA deamination (GO:0045006) | 5.39734171 |
| 5 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.26861140 |
| 6 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 4.54914945 |
| 7 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 4.49105819 |
| 8 | chaperone-mediated protein transport (GO:0072321) | 4.16717987 |
| 9 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.13419098 |
| 10 | rRNA modification (GO:0000154) | 4.03087204 |
| 11 | kynurenine metabolic process (GO:0070189) | 3.90664912 |
| 12 | electron transport chain (GO:0022900) | 3.87182605 |
| 13 | respiratory electron transport chain (GO:0022904) | 3.86173964 |
| 14 | ATP biosynthetic process (GO:0006754) | 3.85279411 |
| 15 | protein complex biogenesis (GO:0070271) | 3.79984556 |
| 16 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.78516844 |
| 17 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.74713830 |
| 18 | purine nucleobase biosynthetic process (GO:0009113) | 3.68682571 |
| 19 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.56990290 |
| 20 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.55776234 |
| 21 | positive regulation of prostaglandin secretion (GO:0032308) | 3.54015097 |
| 22 | ribosomal large subunit biogenesis (GO:0042273) | 3.52893765 |
| 23 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.51631989 |
| 24 | inner mitochondrial membrane organization (GO:0007007) | 3.50569053 |
| 25 | regulation of chronic inflammatory response (GO:0002676) | 3.46651844 |
| 26 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.43058001 |
| 27 | purine-containing compound salvage (GO:0043101) | 3.42642086 |
| 28 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.41038143 |
| 29 | negative regulation of ligase activity (GO:0051352) | 3.40039038 |
| 30 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.40039038 |
| 31 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.38349290 |
| 32 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 3.36426927 |
| 33 | protein neddylation (GO:0045116) | 3.35978920 |
| 34 | purine nucleotide salvage (GO:0032261) | 3.32901293 |
| 35 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.30852525 |
| 36 | proteasome assembly (GO:0043248) | 3.29900271 |
| 37 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.25716389 |
| 38 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.25716389 |
| 39 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.25716389 |
| 40 | nucleobase biosynthetic process (GO:0046112) | 3.23673286 |
| 41 | pseudouridine synthesis (GO:0001522) | 3.21404051 |
| 42 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.20820842 |
| 43 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.20820842 |
| 44 | respiratory chain complex IV assembly (GO:0008535) | 3.18927283 |
| 45 | cytidine deamination (GO:0009972) | 3.18641747 |
| 46 | cytidine metabolic process (GO:0046087) | 3.18641747 |
| 47 | cytidine catabolic process (GO:0006216) | 3.18641747 |
| 48 | cytochrome complex assembly (GO:0017004) | 3.18478806 |
| 49 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.13913734 |
| 50 | negative regulation of heart rate (GO:0010459) | 3.12632187 |
| 51 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.12109241 |
| 52 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.12109241 |
| 53 | NADH dehydrogenase complex assembly (GO:0010257) | 3.12109241 |
| 54 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.09651856 |
| 55 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.09651856 |
| 56 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.08634624 |
| 57 | protein-cofactor linkage (GO:0018065) | 3.07168603 |
| 58 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 3.07078612 |
| 59 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 3.07078612 |
| 60 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.06902883 |
| 61 | rRNA methylation (GO:0031167) | 3.05527435 |
| 62 | tryptophan catabolic process (GO:0006569) | 3.05097134 |
| 63 | indole-containing compound catabolic process (GO:0042436) | 3.05097134 |
| 64 | indolalkylamine catabolic process (GO:0046218) | 3.05097134 |
| 65 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.04815337 |
| 66 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.04815337 |
| 67 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.99795449 |
| 68 | termination of RNA polymerase III transcription (GO:0006386) | 2.99795449 |
| 69 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 2.99629858 |
| 70 | IMP biosynthetic process (GO:0006188) | 2.96286047 |
| 71 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.91889403 |
| 72 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 2.91058388 |
| 73 | positive regulation of protein homodimerization activity (GO:0090073) | 2.90935425 |
| 74 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.89791977 |
| 75 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.89791977 |
| 76 | isotype switching (GO:0045190) | 2.89791977 |
| 77 | neuronal action potential propagation (GO:0019227) | 2.88762783 |
| 78 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.86172580 |
| 79 | positive regulation of ligase activity (GO:0051351) | 2.85888357 |
| 80 | DNA double-strand break processing (GO:0000729) | 2.84538090 |
| 81 | organelle disassembly (GO:1903008) | 2.84087457 |
| 82 | hydrogen ion transmembrane transport (GO:1902600) | 2.82690811 |
| 83 | mast cell degranulation (GO:0043303) | 2.82660206 |
| 84 | mast cell activation involved in immune response (GO:0002279) | 2.82660206 |
| 85 | ribosomal small subunit assembly (GO:0000028) | 2.81940278 |
| 86 | regulation of prostaglandin secretion (GO:0032306) | 2.80843905 |
| 87 | intracellular protein transmembrane import (GO:0044743) | 2.76694988 |
| 88 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.73029464 |
| 89 | kinetochore assembly (GO:0051382) | 2.71917650 |
| 90 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.71809459 |
| 91 | GMP metabolic process (GO:0046037) | 2.70573059 |
| 92 | regulation of cellular amine metabolic process (GO:0033238) | 2.69180899 |
| 93 | regulation of mitochondrial translation (GO:0070129) | 2.68953927 |
| 94 | translation (GO:0006412) | 2.67840869 |
| 95 | piRNA metabolic process (GO:0034587) | 2.65562603 |
| 96 | protein deneddylation (GO:0000338) | 2.64664234 |
| 97 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.62998534 |
| 98 | tryptophan metabolic process (GO:0006568) | 2.60577841 |
| 99 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 2.60492933 |
| 100 | protein peptidyl-prolyl isomerization (GO:0000413) | 2.59689372 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.54450716 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.19455340 |
| 3 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.81383200 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.77533878 |
| 5 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.02606575 |
| 6 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.97916606 |
| 7 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.81760685 |
| 8 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.77017370 |
| 9 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.60076704 |
| 10 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.53536697 |
| 11 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.51710041 |
| 12 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.48995178 |
| 13 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.46482588 |
| 14 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.44707507 |
| 15 | VDR_22108803_ChIP-Seq_LS180_Human | 2.29584984 |
| 16 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.27521488 |
| 17 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.24734812 |
| 18 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.20484912 |
| 19 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.18129056 |
| 20 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.17778133 |
| 21 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.14623085 |
| 22 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.06178591 |
| 23 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.99813479 |
| 24 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.98011600 |
| 25 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.92935604 |
| 26 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.92569608 |
| 27 | EWS_26573619_Chip-Seq_HEK293_Human | 1.92343250 |
| 28 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.90758358 |
| 29 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.89810443 |
| 30 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.78768548 |
| 31 | FUS_26573619_Chip-Seq_HEK293_Human | 1.72023482 |
| 32 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.71685280 |
| 33 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.67954397 |
| 34 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.64125478 |
| 35 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.63269918 |
| 36 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.55074245 |
| 37 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.55039910 |
| 38 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.53511182 |
| 39 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.50836791 |
| 40 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.50675370 |
| 41 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.50324709 |
| 42 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.46093456 |
| 43 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.43792610 |
| 44 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.41993619 |
| 45 | P300_19829295_ChIP-Seq_ESCs_Human | 1.40451737 |
| 46 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.39157788 |
| 47 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.38577690 |
| 48 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.35336915 |
| 49 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.33911132 |
| 50 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.32028483 |
| 51 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.30983709 |
| 52 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.30183599 |
| 53 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.30183599 |
| 54 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.27648348 |
| 55 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.27648348 |
| 56 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.27347972 |
| 57 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.26728814 |
| 58 | GATA3_26560356_Chip-Seq_TH2_Human | 1.26609174 |
| 59 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.26416025 |
| 60 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.25101710 |
| 61 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.24957640 |
| 62 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.23208010 |
| 63 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.22850440 |
| 64 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.21816326 |
| 65 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.19896003 |
| 66 | AR_20517297_ChIP-Seq_VCAP_Human | 1.17337672 |
| 67 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.16906052 |
| 68 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.15645010 |
| 69 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.14791257 |
| 70 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.09958142 |
| 71 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.09622965 |
| 72 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.09128547 |
| 73 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.08852140 |
| 74 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.06120732 |
| 75 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.06024151 |
| 76 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.05524572 |
| 77 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.04295869 |
| 78 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.03950286 |
| 79 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.03720251 |
| 80 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.03345199 |
| 81 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.02008557 |
| 82 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.98927439 |
| 83 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.98193186 |
| 84 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.96715823 |
| 85 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.95770256 |
| 86 | GATA3_26560356_Chip-Seq_TH1_Human | 0.95656012 |
| 87 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.95454760 |
| 88 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.94814001 |
| 89 | MYB_26560356_Chip-Seq_TH2_Human | 0.94230389 |
| 90 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 0.92267093 |
| 91 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.91730248 |
| 92 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.91379388 |
| 93 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.91058738 |
| 94 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.90954620 |
| 95 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.90392694 |
| 96 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.90392694 |
| 97 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.89980268 |
| 98 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.88358316 |
| 99 | NCOR_22424771_ChIP-Seq_293T_Human | 0.88024526 |
| 100 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.86085988 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008877_abnormal_DNA_methylation | 3.37704333 |
| 2 | MP0008058_abnormal_DNA_repair | 3.07420586 |
| 3 | MP0005671_abnormal_response_to | 2.99528554 |
| 4 | MP0006072_abnormal_retinal_apoptosis | 2.95220088 |
| 5 | MP0001835_abnormal_antigen_presentation | 2.90710124 |
| 6 | MP0003806_abnormal_nucleotide_metabolis | 2.89479692 |
| 7 | MP0008875_abnormal_xenobiotic_pharmacok | 2.82221411 |
| 8 | MP0005084_abnormal_gallbladder_morpholo | 2.62318703 |
| 9 | MP0004147_increased_porphyrin_level | 2.45725563 |
| 10 | MP0003195_calcinosis | 2.24106354 |
| 11 | MP0002138_abnormal_hepatobiliary_system | 2.22476412 |
| 12 | MP0002166_altered_tumor_susceptibility | 2.22398657 |
| 13 | MP0006292_abnormal_olfactory_placode | 2.17571924 |
| 14 | MP0001348_abnormal_lacrimal_gland | 2.11875649 |
| 15 | MP0010094_abnormal_chromosome_stability | 2.08744263 |
| 16 | MP0000372_irregular_coat_pigmentation | 2.07645262 |
| 17 | MP0002006_tumorigenesis | 1.93754119 |
| 18 | MP0002736_abnormal_nociception_after | 1.88691655 |
| 19 | MP0009697_abnormal_copulation | 1.79493795 |
| 20 | MP0002102_abnormal_ear_morphology | 1.77285689 |
| 21 | MP0001873_stomach_inflammation | 1.69672769 |
| 22 | MP0008872_abnormal_physiological_respon | 1.69589435 |
| 23 | MP0005645_abnormal_hypothalamus_physiol | 1.66585387 |
| 24 | MP0001968_abnormal_touch/_nociception | 1.65844306 |
| 25 | MP0000685_abnormal_immune_system | 1.62135442 |
| 26 | MP0003693_abnormal_embryo_hatching | 1.55411801 |
| 27 | MP0002254_reproductive_system_inflammat | 1.52989649 |
| 28 | MP0003786_premature_aging | 1.52470716 |
| 29 | MP0005253_abnormal_eye_physiology | 1.51534331 |
| 30 | MP0006035_abnormal_mitochondrial_morpho | 1.51208030 |
| 31 | MP0002876_abnormal_thyroid_physiology | 1.51089700 |
| 32 | MP0002938_white_spotting | 1.47210898 |
| 33 | MP0006036_abnormal_mitochondrial_physio | 1.46758293 |
| 34 | MP0001800_abnormal_humoral_immune | 1.45114473 |
| 35 | MP0005551_abnormal_eye_electrophysiolog | 1.44938470 |
| 36 | MP0001919_abnormal_reproductive_system | 1.36235855 |
| 37 | MP0005387_immune_system_phenotype | 1.35687547 |
| 38 | MP0001790_abnormal_immune_system | 1.35687547 |
| 39 | MP0004957_abnormal_blastocyst_morpholog | 1.34462319 |
| 40 | MP0009333_abnormal_splenocyte_physiolog | 1.33740920 |
| 41 | MP0009785_altered_susceptibility_to | 1.31067056 |
| 42 | MP0003763_abnormal_thymus_physiology | 1.28817828 |
| 43 | MP0005389_reproductive_system_phenotype | 1.27609530 |
| 44 | MP0003252_abnormal_bile_duct | 1.25811660 |
| 45 | MP0002160_abnormal_reproductive_system | 1.19166194 |
| 46 | MP0003787_abnormal_imprinting | 1.17226725 |
| 47 | MP0001293_anophthalmia | 1.16711541 |
| 48 | MP0001501_abnormal_sleep_pattern | 1.16107197 |
| 49 | MP0002090_abnormal_vision | 1.11724608 |
| 50 | MP0001986_abnormal_taste_sensitivity | 1.10952595 |
| 51 | MP0001984_abnormal_olfaction | 1.09760196 |
| 52 | MP0005085_abnormal_gallbladder_physiolo | 1.08705426 |
| 53 | MP0006082_CNS_inflammation | 1.05944886 |
| 54 | MP0009745_abnormal_behavioral_response | 1.05339314 |
| 55 | MP0003880_abnormal_central_pattern | 1.03793918 |
| 56 | MP0003111_abnormal_nucleus_morphology | 1.03697670 |
| 57 | MP0004142_abnormal_muscle_tone | 1.02293426 |
| 58 | MP0002452_abnormal_antigen_presenting | 1.02287926 |
| 59 | MP0002277_abnormal_respiratory_mucosa | 1.02229604 |
| 60 | MP0003718_maternal_effect | 1.01567858 |
| 61 | MP0003866_abnormal_defecation | 1.01341796 |
| 62 | MP0002723_abnormal_immune_serum | 1.00717092 |
| 63 | MP0001905_abnormal_dopamine_level | 1.00078813 |
| 64 | MP0001929_abnormal_gametogenesis | 0.99555239 |
| 65 | MP0006276_abnormal_autonomic_nervous | 0.99374103 |
| 66 | MP0005000_abnormal_immune_tolerance | 0.99197398 |
| 67 | MP0003077_abnormal_cell_cycle | 0.98150534 |
| 68 | MP0001486_abnormal_startle_reflex | 0.96597195 |
| 69 | MP0002272_abnormal_nervous_system | 0.95743622 |
| 70 | MP0002148_abnormal_hypersensitivity_rea | 0.95719264 |
| 71 | MP0001819_abnormal_immune_cell | 0.95635845 |
| 72 | MP0001764_abnormal_homeostasis | 0.95289764 |
| 73 | MP0002837_dystrophic_cardiac_calcinosis | 0.93650098 |
| 74 | MP0001346_abnormal_lacrimal_gland | 0.91891805 |
| 75 | MP0005167_abnormal_blood-brain_barrier | 0.91459783 |
| 76 | MP0002420_abnormal_adaptive_immunity | 0.91024292 |
| 77 | MP0002210_abnormal_sex_determination | 0.90898576 |
| 78 | MP0008995_early_reproductive_senescence | 0.90134152 |
| 79 | MP0003186_abnormal_redox_activity | 0.89571264 |
| 80 | MP0008007_abnormal_cellular_replicative | 0.87839167 |
| 81 | MP0009764_decreased_sensitivity_to | 0.85878308 |
| 82 | MP0009046_muscle_twitch | 0.85361716 |
| 83 | MP0003646_muscle_fatigue | 0.83524070 |
| 84 | MP0005646_abnormal_pituitary_gland | 0.82693362 |
| 85 | MP0005410_abnormal_fertilization | 0.82388737 |
| 86 | MP0003724_increased_susceptibility_to | 0.80971100 |
| 87 | MP0002933_joint_inflammation | 0.80265498 |
| 88 | MP0002733_abnormal_thermal_nociception | 0.80044708 |
| 89 | MP0005310_abnormal_salivary_gland | 0.79053306 |
| 90 | MP0003567_abnormal_fetal_cardiomyocyte | 0.78580536 |
| 91 | MP0000653_abnormal_sex_gland | 0.77908251 |
| 92 | MP0010155_abnormal_intestine_physiology | 0.77875537 |
| 93 | MP0002735_abnormal_chemical_nociception | 0.76953122 |
| 94 | MP0001502_abnormal_circadian_rhythm | 0.76524351 |
| 95 | MP0003436_decreased_susceptibility_to | 0.74997826 |
| 96 | MP0002751_abnormal_autonomic_nervous | 0.74812058 |
| 97 | MP0001970_abnormal_pain_threshold | 0.74798562 |
| 98 | MP0005075_abnormal_melanosome_morpholog | 0.74203656 |
| 99 | MP0003137_abnormal_impulse_conducting | 0.73882409 |
| 100 | MP0003698_abnormal_male_reproductive | 0.71892312 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Congenital, generalized hypertrichosis (HP:0004540) | 4.49991652 |
| 2 | Testicular atrophy (HP:0000029) | 4.39748429 |
| 3 | Acute necrotizing encephalopathy (HP:0006965) | 4.12069272 |
| 4 | Lipid accumulation in hepatocytes (HP:0006561) | 4.10909223 |
| 5 | Mitochondrial inheritance (HP:0001427) | 3.87749006 |
| 6 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.72319475 |
| 7 | Increased hepatocellular lipid droplets (HP:0006565) | 3.69496705 |
| 8 | Increased CSF lactate (HP:0002490) | 3.68432525 |
| 9 | 3-Methylglutaconic aciduria (HP:0003535) | 3.63338372 |
| 10 | Progressive macrocephaly (HP:0004481) | 3.46650191 |
| 11 | Acute encephalopathy (HP:0006846) | 3.46592290 |
| 12 | IgG deficiency (HP:0004315) | 3.25247757 |
| 13 | Methylmalonic acidemia (HP:0002912) | 3.15710363 |
| 14 | Autoimmune thrombocytopenia (HP:0001973) | 3.06475278 |
| 15 | Hepatocellular necrosis (HP:0001404) | 2.87627238 |
| 16 | Cerebral edema (HP:0002181) | 2.83877406 |
| 17 | Autoimmune hemolytic anemia (HP:0001890) | 2.82039978 |
| 18 | Increased serum lactate (HP:0002151) | 2.66719896 |
| 19 | Hepatic necrosis (HP:0002605) | 2.66394974 |
| 20 | Abolished electroretinogram (ERG) (HP:0000550) | 2.57011940 |
| 21 | Increased muscle lipid content (HP:0009058) | 2.52130637 |
| 22 | Optic disc pallor (HP:0000543) | 2.49943998 |
| 23 | Increased intramyocellular lipid droplets (HP:0012240) | 2.48868453 |
| 24 | Renal Fanconi syndrome (HP:0001994) | 2.48774529 |
| 25 | Congenital stationary night blindness (HP:0007642) | 2.45969192 |
| 26 | Supernumerary spleens (HP:0009799) | 2.43013266 |
| 27 | Type 2 muscle fiber atrophy (HP:0003554) | 2.40333745 |
| 28 | Hypoplasia of the pons (HP:0012110) | 2.37751113 |
| 29 | Pancreatic cysts (HP:0001737) | 2.37058705 |
| 30 | Methylmalonic aciduria (HP:0012120) | 2.35277449 |
| 31 | B lymphocytopenia (HP:0010976) | 2.34876918 |
| 32 | Hypomagnesemia (HP:0002917) | 2.34501358 |
| 33 | Exertional dyspnea (HP:0002875) | 2.33183559 |
| 34 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.31644178 |
| 35 | Attenuation of retinal blood vessels (HP:0007843) | 2.31402305 |
| 36 | Lactic acidosis (HP:0003128) | 2.30509838 |
| 37 | Abnormality of the pons (HP:0007361) | 2.30291812 |
| 38 | Megaloblastic anemia (HP:0001889) | 2.29488815 |
| 39 | Pancreatic fibrosis (HP:0100732) | 2.24248428 |
| 40 | Opisthotonus (HP:0002179) | 2.23564695 |
| 41 | Nephronophthisis (HP:0000090) | 2.22198871 |
| 42 | Tetraparesis (HP:0002273) | 2.21686356 |
| 43 | Abnormality of B cell number (HP:0010975) | 2.15331469 |
| 44 | Dyschromatopsia (HP:0007641) | 2.14167184 |
| 45 | Prostate neoplasm (HP:0100787) | 2.14121417 |
| 46 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.13135260 |
| 47 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.11839477 |
| 48 | Lethargy (HP:0001254) | 2.11655602 |
| 49 | Macrocytic anemia (HP:0001972) | 2.10999163 |
| 50 | Molar tooth sign on MRI (HP:0002419) | 2.10911208 |
| 51 | Abnormality of midbrain morphology (HP:0002418) | 2.10911208 |
| 52 | Chronic sinusitis (HP:0011109) | 2.09479485 |
| 53 | Hyperglycinuria (HP:0003108) | 2.07363685 |
| 54 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.06064302 |
| 55 | Stomatitis (HP:0010280) | 2.05490119 |
| 56 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.04737835 |
| 57 | Large for gestational age (HP:0001520) | 2.04613603 |
| 58 | Abnormality of the prostate (HP:0008775) | 2.03408424 |
| 59 | Abnormality of T cells (HP:0002843) | 2.03233761 |
| 60 | Abnormality of T cell physiology (HP:0011840) | 1.98859712 |
| 61 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.98059670 |
| 62 | Ketoacidosis (HP:0001993) | 1.95171555 |
| 63 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.94837960 |
| 64 | Exercise intolerance (HP:0003546) | 1.94587278 |
| 65 | Respiratory failure (HP:0002878) | 1.94530888 |
| 66 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.93228539 |
| 67 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.93228539 |
| 68 | Adrenal hypoplasia (HP:0000835) | 1.91597834 |
| 69 | Muscle fiber atrophy (HP:0100295) | 1.90068683 |
| 70 | Abnormality of magnesium homeostasis (HP:0004921) | 1.87846316 |
| 71 | Abnormality of vitamin B metabolism (HP:0004340) | 1.87287645 |
| 72 | Abnormality of methionine metabolism (HP:0010901) | 1.86250687 |
| 73 | Parakeratosis (HP:0001036) | 1.85475412 |
| 74 | Abnormality of the labia minora (HP:0012880) | 1.84934325 |
| 75 | Abnormal spermatogenesis (HP:0008669) | 1.84716403 |
| 76 | Abnormality of macular pigmentation (HP:0008002) | 1.84540373 |
| 77 | Azoospermia (HP:0000027) | 1.84310226 |
| 78 | Abnormality of the ileum (HP:0001549) | 1.83674900 |
| 79 | Amniotic constriction ring (HP:0009775) | 1.82781864 |
| 80 | Abnormality of placental membranes (HP:0011409) | 1.82781864 |
| 81 | Meckel diverticulum (HP:0002245) | 1.81811104 |
| 82 | Cerebral palsy (HP:0100021) | 1.80848949 |
| 83 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.79315902 |
| 84 | Pancytopenia (HP:0001876) | 1.78709409 |
| 85 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.76768504 |
| 86 | Recurrent cutaneous fungal infections (HP:0011370) | 1.76768504 |
| 87 | Abnormality of eosinophils (HP:0001879) | 1.75753579 |
| 88 | True hermaphroditism (HP:0010459) | 1.74743686 |
| 89 | Severe combined immunodeficiency (HP:0004430) | 1.74373108 |
| 90 | Abnormality of the renal medulla (HP:0100957) | 1.74114247 |
| 91 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.73823836 |
| 92 | Abnormality of glycine metabolism (HP:0010895) | 1.73823836 |
| 93 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.69589976 |
| 94 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.69332090 |
| 95 | Visual hallucinations (HP:0002367) | 1.69252853 |
| 96 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.68648463 |
| 97 | Hypoproteinemia (HP:0003075) | 1.67343774 |
| 98 | Constricted visual fields (HP:0001133) | 1.66720207 |
| 99 | Leukodystrophy (HP:0002415) | 1.66069505 |
| 100 | Erythroderma (HP:0001019) | 1.65564937 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TAOK3 | 3.44113519 |
| 2 | TSSK6 | 3.23929755 |
| 3 | NEK1 | 2.96960930 |
| 4 | NUAK1 | 2.92311610 |
| 5 | ZAK | 2.87859517 |
| 6 | TXK | 2.85990595 |
| 7 | TLK1 | 2.73017052 |
| 8 | MAP3K12 | 2.56170496 |
| 9 | MAP4K2 | 2.51087897 |
| 10 | BUB1 | 2.37296709 |
| 11 | EIF2AK3 | 2.28772389 |
| 12 | ADRBK2 | 2.15039545 |
| 13 | VRK2 | 2.09155212 |
| 14 | KIT | 2.08445621 |
| 15 | INSRR | 2.06051095 |
| 16 | MST4 | 1.89541973 |
| 17 | VRK1 | 1.89209160 |
| 18 | PBK | 1.80731848 |
| 19 | MKNK1 | 1.80555627 |
| 20 | EIF2AK1 | 1.77946180 |
| 21 | PLK3 | 1.68021195 |
| 22 | GRK1 | 1.65118486 |
| 23 | PLK4 | 1.57380542 |
| 24 | WNK3 | 1.54576030 |
| 25 | BMPR2 | 1.50325099 |
| 26 | FRK | 1.44358301 |
| 27 | MAP4K1 | 1.25049679 |
| 28 | WNK4 | 1.24430037 |
| 29 | EIF2AK2 | 1.08524692 |
| 30 | SRPK1 | 1.06916776 |
| 31 | ERBB3 | 1.06818356 |
| 32 | PLK2 | 1.06604167 |
| 33 | BCKDK | 1.06152085 |
| 34 | TRIM28 | 1.03650881 |
| 35 | STK39 | 1.03113896 |
| 36 | MKNK2 | 1.01322043 |
| 37 | WEE1 | 0.99103487 |
| 38 | GRK6 | 0.98915125 |
| 39 | CDC7 | 0.98898508 |
| 40 | PASK | 0.92959458 |
| 41 | OXSR1 | 0.90841709 |
| 42 | IKBKE | 0.87444220 |
| 43 | MATK | 0.86653647 |
| 44 | SYK | 0.86526168 |
| 45 | MYLK | 0.85764941 |
| 46 | TIE1 | 0.85319751 |
| 47 | FES | 0.85093448 |
| 48 | TEC | 0.81706172 |
| 49 | IKBKB | 0.81496689 |
| 50 | PNCK | 0.76897162 |
| 51 | CDK19 | 0.76014477 |
| 52 | BMPR1B | 0.75349598 |
| 53 | MAPK15 | 0.75271767 |
| 54 | PLK1 | 0.69194636 |
| 55 | AURKB | 0.67891054 |
| 56 | TAF1 | 0.65953669 |
| 57 | TGFBR1 | 0.62229288 |
| 58 | PTK2B | 0.62210230 |
| 59 | PINK1 | 0.61991609 |
| 60 | SCYL2 | 0.61234217 |
| 61 | STK16 | 0.58447253 |
| 62 | RPS6KA5 | 0.58174708 |
| 63 | TNIK | 0.58065967 |
| 64 | TTK | 0.54055377 |
| 65 | KDR | 0.53763406 |
| 66 | LYN | 0.51972401 |
| 67 | ALK | 0.51679295 |
| 68 | ITK | 0.49020584 |
| 69 | DAPK1 | 0.48850992 |
| 70 | ADRBK1 | 0.48504896 |
| 71 | FLT3 | 0.48047814 |
| 72 | CSNK2A1 | 0.47346632 |
| 73 | CAMK2A | 0.46882514 |
| 74 | PHKG2 | 0.44583792 |
| 75 | PHKG1 | 0.44583792 |
| 76 | RPS6KA4 | 0.43900508 |
| 77 | PIK3CG | 0.43202316 |
| 78 | MAP2K6 | 0.41720672 |
| 79 | PRKG1 | 0.41322926 |
| 80 | IGF1R | 0.41159346 |
| 81 | MAP2K2 | 0.39886802 |
| 82 | CSNK1G2 | 0.38983164 |
| 83 | CSNK1A1 | 0.38669286 |
| 84 | CCNB1 | 0.38600869 |
| 85 | DYRK2 | 0.38575398 |
| 86 | MAP3K4 | 0.38309696 |
| 87 | BRSK2 | 0.38161022 |
| 88 | JAK3 | 0.37602993 |
| 89 | GRK5 | 0.36635423 |
| 90 | NEK6 | 0.36056488 |
| 91 | CSNK2A2 | 0.35453314 |
| 92 | CAMK2D | 0.34844848 |
| 93 | PRKCQ | 0.34834065 |
| 94 | PRKCG | 0.34461151 |
| 95 | CAMKK2 | 0.34407702 |
| 96 | NLK | 0.33990196 |
| 97 | PRKCE | 0.33949974 |
| 98 | BTK | 0.33169149 |
| 99 | LCK | 0.33075666 |
| 100 | PRKACA | 0.31813634 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.61979783 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.45582696 |
| 3 | Asthma_Homo sapiens_hsa05310 | 3.13237650 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.07821233 |
| 5 | Ribosome_Homo sapiens_hsa03010 | 3.00492173 |
| 6 | Protein export_Homo sapiens_hsa03060 | 2.86525423 |
| 7 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.34931778 |
| 8 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.30161335 |
| 9 | RNA polymerase_Homo sapiens_hsa03020 | 2.27413493 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.11261520 |
| 11 | Alzheimers disease_Homo sapiens_hsa05010 | 2.06198345 |
| 12 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.05295696 |
| 13 | Allograft rejection_Homo sapiens_hsa05330 | 2.03069931 |
| 14 | Huntingtons disease_Homo sapiens_hsa05016 | 2.01961980 |
| 15 | Mismatch repair_Homo sapiens_hsa03430 | 1.93132571 |
| 16 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.91877223 |
| 17 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.80822816 |
| 18 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.70832680 |
| 19 | RNA degradation_Homo sapiens_hsa03018 | 1.70281330 |
| 20 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.61283862 |
| 21 | DNA replication_Homo sapiens_hsa03030 | 1.61230983 |
| 22 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.61144863 |
| 23 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.60553666 |
| 24 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.55449997 |
| 25 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.53372002 |
| 26 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.52059721 |
| 27 | Spliceosome_Homo sapiens_hsa03040 | 1.51993502 |
| 28 | Basal transcription factors_Homo sapiens_hsa03022 | 1.51857786 |
| 29 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.44525737 |
| 30 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.42132731 |
| 31 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.31708238 |
| 32 | Phototransduction_Homo sapiens_hsa04744 | 1.31296829 |
| 33 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.28556587 |
| 34 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.25586371 |
| 35 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.22732052 |
| 36 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.20079649 |
| 37 | Purine metabolism_Homo sapiens_hsa00230 | 1.17598921 |
| 38 | Base excision repair_Homo sapiens_hsa03410 | 1.12697085 |
| 39 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.12362942 |
| 40 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.07341967 |
| 41 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.06585976 |
| 42 | RNA transport_Homo sapiens_hsa03013 | 1.03690746 |
| 43 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.01936158 |
| 44 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.01860851 |
| 45 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.98819549 |
| 46 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.96516284 |
| 47 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.94405947 |
| 48 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.93302057 |
| 49 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.87934416 |
| 50 | Peroxisome_Homo sapiens_hsa04146 | 0.87443100 |
| 51 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.86707652 |
| 52 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.82227364 |
| 53 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.76824020 |
| 54 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.75712501 |
| 55 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.75661475 |
| 56 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.73766131 |
| 57 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.73122456 |
| 58 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.73027130 |
| 59 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.71803826 |
| 60 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.69450845 |
| 61 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.65731919 |
| 62 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.65691766 |
| 63 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.65422391 |
| 64 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.64758015 |
| 65 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.62989820 |
| 66 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.60580897 |
| 67 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.60313502 |
| 68 | Metabolic pathways_Homo sapiens_hsa01100 | 0.59627380 |
| 69 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.59379628 |
| 70 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.57593469 |
| 71 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.57101621 |
| 72 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.56650107 |
| 73 | Olfactory transduction_Homo sapiens_hsa04740 | 0.50408414 |
| 74 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.50132369 |
| 75 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.44035656 |
| 76 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.43610787 |
| 77 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.42879487 |
| 78 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.42788197 |
| 79 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.41639645 |
| 80 | Nicotine addiction_Homo sapiens_hsa05033 | 0.41314985 |
| 81 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.39180108 |
| 82 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.37132730 |
| 83 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.34101672 |
| 84 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.33785383 |
| 85 | Mineral absorption_Homo sapiens_hsa04978 | 0.33235744 |
| 86 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.32797205 |
| 87 | Morphine addiction_Homo sapiens_hsa05032 | 0.30289953 |
| 88 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.30005539 |
| 89 | Cell cycle_Homo sapiens_hsa04110 | 0.29630360 |
| 90 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.27266683 |
| 91 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.27206177 |
| 92 | Retinol metabolism_Homo sapiens_hsa00830 | 0.26289183 |
| 93 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.24894370 |
| 94 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.24294122 |
| 95 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.22868188 |
| 96 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.21775804 |
| 97 | Salivary secretion_Homo sapiens_hsa04970 | 0.21063158 |
| 98 | Taste transduction_Homo sapiens_hsa04742 | 0.20791031 |
| 99 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.20481968 |
| 100 | GABAergic synapse_Homo sapiens_hsa04727 | 0.18723415 |

