HNRNPA1P33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.54297660
2keratinocyte proliferation (GO:0043616)5.24705620
3bundle of His cell to Purkinje myocyte communication (GO:0086069)5.12358039
4keratinocyte development (GO:0003334)4.68155624
5establishment of skin barrier (GO:0061436)4.66561617
6gap junction assembly (GO:0016264)4.39791360
7ribosomal large subunit biogenesis (GO:0042273)4.35541770
8DNA deamination (GO:0045006)4.21832178
9ribosomal small subunit assembly (GO:0000028)4.15676063
10positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.15046915
11lateral sprouting from an epithelium (GO:0060601)3.96855780
12ribosome assembly (GO:0042255)3.95220633
13regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.89748332
14proteasome assembly (GO:0043248)3.88560574
15regulation of water loss via skin (GO:0033561)3.81261244
16negative regulation of keratinocyte proliferation (GO:0010839)3.78245700
17keratinization (GO:0031424)3.60482235
18sequestering of actin monomers (GO:0042989)3.60463873
19regulation of memory T cell differentiation (GO:0043380)3.57973302
20positive regulation of interleukin-17 production (GO:0032740)3.56028321
21ribonucleoprotein complex biogenesis (GO:0022613)3.50183924
22molting cycle (GO:0042303)3.49540092
23hair cycle (GO:0042633)3.49540092
24nucleoside transmembrane transport (GO:1901642)3.44243002
25ribosome biogenesis (GO:0042254)3.42956398
26polarized epithelial cell differentiation (GO:0030859)3.39236806
27cornea development in camera-type eye (GO:0061303)3.39133526
28regulation of cellular amino acid metabolic process (GO:0006521)3.38923597
29nucleoside transport (GO:0015858)3.36183952
30transcription elongation from RNA polymerase I promoter (GO:0006362)3.34923401
31positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.34364654
32maturation of SSU-rRNA (GO:0030490)3.30564566
33regulation of keratinocyte proliferation (GO:0010837)3.30148709
34intermediate filament organization (GO:0045109)3.26872144
35viral transcription (GO:0019083)3.20504500
36translational termination (GO:0006415)3.20358161
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19283049
38cotranslational protein targeting to membrane (GO:0006613)3.13128594
39protein targeting to ER (GO:0045047)3.11046648
40negative regulation of cell aging (GO:0090344)3.07555852
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.04413357
42translational elongation (GO:0006414)3.04157009
43positive regulation of hair follicle development (GO:0051798)3.02544332
44positive regulation of hair cycle (GO:0042635)3.02544332
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.02489910
46regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.02338004
47epidermis development (GO:0008544)3.02070546
48ribosomal small subunit biogenesis (GO:0042274)3.01498996
49protein localization to endoplasmic reticulum (GO:0070972)2.98294811
50RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.95683747
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95598965
52rRNA processing (GO:0006364)2.93938297
53keratinocyte differentiation (GO:0030216)2.93456747
54DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93259006
55translational initiation (GO:0006413)2.92808322
56protein neddylation (GO:0045116)2.92336569
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.92179495
58signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.90000862
59signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.90000862
60signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.90000862
61rRNA metabolic process (GO:0016072)2.87626069
62intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.87030409
63signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.87030409
64behavioral response to nicotine (GO:0035095)2.85746929
65organ formation (GO:0048645)2.82875397
66formation of translation preinitiation complex (GO:0001731)2.82762644
67rRNA modification (GO:0000154)2.79819522
68signal transduction involved in DNA damage checkpoint (GO:0072422)2.77642425
69signal transduction involved in DNA integrity checkpoint (GO:0072401)2.77642425
70translation (GO:0006412)2.76913642
71negative regulation of acute inflammatory response (GO:0002674)2.76644372
72cellular component biogenesis (GO:0044085)2.76449944
73regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.75480926
74AMP metabolic process (GO:0046033)2.74504889
75signal transduction involved in cell cycle checkpoint (GO:0072395)2.74439304
76cell-substrate junction assembly (GO:0007044)2.73103758
77protein autoprocessing (GO:0016540)2.72314117
78diterpenoid biosynthetic process (GO:0016102)2.71738670
79regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70289017
80regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.68751008
81GMP metabolic process (GO:0046037)2.67471595
82regulation of activation of Janus kinase activity (GO:0010533)2.65099850
83negative regulation of ligase activity (GO:0051352)2.64850599
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.64850599
85energy coupled proton transport, down electrochemical gradient (GO:0015985)2.63687487
86ATP synthesis coupled proton transport (GO:0015986)2.63687487
87drug transmembrane transport (GO:0006855)2.62362823
88type B pancreatic cell proliferation (GO:0044342)2.62191604
89DNA double-strand break processing (GO:0000729)2.62008815
90hepatocyte differentiation (GO:0070365)2.61101224
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.60634146
92polyketide metabolic process (GO:0030638)2.59939110
93doxorubicin metabolic process (GO:0044598)2.59939110
94daunorubicin metabolic process (GO:0044597)2.59939110
95terpenoid biosynthetic process (GO:0016114)2.57312066
96base-excision repair, AP site formation (GO:0006285)2.56869481
97positive regulation of T-helper 1 type immune response (GO:0002827)2.54306043
98antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.53240777
99positive regulation of T cell mediated cytotoxicity (GO:0001916)2.53121441
100hemidesmosome assembly (GO:0031581)10.2005470

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.80128745
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.62432691
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.30880011
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.28959730
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.02903782
6ZNF263_19887448_ChIP-Seq_K562_Human3.01127873
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.80331974
8ELK1_19687146_ChIP-ChIP_HELA_Human2.64271624
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.54511753
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.45197972
11ZNF274_21170338_ChIP-Seq_K562_Hela2.22583007
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14844476
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.11357071
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02965357
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02936775
16TP63_17297297_ChIP-ChIP_HaCaT_Human10.0298707
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97564889
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95266810
19SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.92235472
20SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.92235472
21VDR_23849224_ChIP-Seq_CD4+_Human1.85670591
22MYC_19030024_ChIP-ChIP_MESCs_Mouse1.81961792
23IGF1R_20145208_ChIP-Seq_DFB_Human1.81551170
24ELK1_22589737_ChIP-Seq_MCF10A_Human1.76706385
25P63_26484246_Chip-Seq_KERATINOCYTES_Human1.73724577
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68352799
27DCP1A_22483619_ChIP-Seq_HELA_Human1.64687158
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59791260
29TAF15_26573619_Chip-Seq_HEK293_Human1.57063309
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55734667
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55674311
32EWS_26573619_Chip-Seq_HEK293_Human1.55076522
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53975208
34VDR_22108803_ChIP-Seq_LS180_Human1.48309388
35MYC_18940864_ChIP-ChIP_HL60_Human1.46540964
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45387056
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.43325858
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42524028
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39652927
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38769872
41FUS_26573619_Chip-Seq_HEK293_Human1.37225980
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36073158
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34717598
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34642697
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34383691
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.33562653
47PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.33385806
48FOXP3_21729870_ChIP-Seq_TREG_Human1.29265415
49TTF2_22483619_ChIP-Seq_HELA_Human1.27065044
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25566472
51TP63_23658742_ChIP-Seq_EP156T_Human1.24363210
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.23226261
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22538565
54AR_21909140_ChIP-Seq_LNCAP_Human1.17811478
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.17413238
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14334507
57CJUN_26792858_Chip-Seq_BT549_Human1.07997038
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.07820795
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06920781
60E2F7_22180533_ChIP-Seq_HELA_Human1.06433323
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04675730
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.04655156
63ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04341613
64ELF5_23300383_ChIP-Seq_T47D_Human1.04336915
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02974813
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.02974813
67ER_23166858_ChIP-Seq_MCF-7_Human1.01810489
68GATA4_25053715_ChIP-Seq_YYC3_Human1.00104695
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98184452
70AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97109366
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96298758
72NANOG_19829295_ChIP-Seq_ESCs_Human0.92796356
73SOX2_19829295_ChIP-Seq_ESCs_Human0.92796356
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92407836
75GATA3_24758297_ChIP-Seq_MCF-7_Human0.90740288
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.90116706
77XRN2_22483619_ChIP-Seq_HELA_Human0.89753645
78AR_20517297_ChIP-Seq_VCAP_Human0.89626440
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86581971
80HTT_18923047_ChIP-ChIP_STHdh_Human0.85502555
81EZH2_27294783_Chip-Seq_NPCs_Mouse0.85378694
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84645828
83PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84261196
84TP53_18474530_ChIP-ChIP_U2OS_Human0.84220358
85TAF2_19829295_ChIP-Seq_ESCs_Human0.84193421
86E2F1_21310950_ChIP-Seq_MCF-7_Human0.83806792
87GABP_19822575_ChIP-Seq_HepG2_Human0.83748799
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83151128
89NFE2_27457419_Chip-Seq_LIVER_Mouse0.82791448
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82525984
91CBP_20019798_ChIP-Seq_JUKART_Human0.82525984
92HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80720538
93BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79828235
94CTBP1_25329375_ChIP-Seq_LNCAP_Human0.78967853
95PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78657866
96GATA1_22025678_ChIP-Seq_K562_Human0.77019372
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.76633704
98JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75558719
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75084916
100FOXA1_21572438_ChIP-Seq_LNCaP_Human0.74338736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology6.39452213
2MP0000566_synostosis4.58522800
3MP0010234_abnormal_vibrissa_follicle3.86735349
4MP0002796_impaired_skin_barrier3.51574828
5MP0002234_abnormal_pharynx_morphology3.15201344
6MP0009053_abnormal_anal_canal2.77233358
7MP0000762_abnormal_tongue_morphology2.75402406
8MP0000467_abnormal_esophagus_morphology2.75352321
9MP0010678_abnormal_skin_adnexa2.73872390
10MP0000383_abnormal_hair_follicle2.51640122
11MP0003806_abnormal_nucleotide_metabolis2.50738308
12MP0001216_abnormal_epidermal_layer2.47521639
13MP0008875_abnormal_xenobiotic_pharmacok2.42524279
14MP0005501_abnormal_skin_physiology2.38357411
15MP0002098_abnormal_vibrissa_morphology2.26591218
16MP0005275_abnormal_skin_tensile2.20174823
17MP0003941_abnormal_skin_development2.17974038
18MP0005360_urolithiasis2.13958261
19MP0002060_abnormal_skin_morphology2.09998263
20MP0004957_abnormal_blastocyst_morpholog2.01555983
21MP0009697_abnormal_copulation1.97010986
22MP0010771_integument_phenotype1.94808008
23MP0000537_abnormal_urethra_morphology1.94168452
24MP0001348_abnormal_lacrimal_gland1.78759440
25MP0004782_abnormal_surfactant_physiolog1.75673003
26MP0001661_extended_life_span1.73033221
27MP0003693_abnormal_embryo_hatching1.65776807
28MP0000377_abnormal_hair_follicle1.63232930
29MP0000647_abnormal_sebaceous_gland1.60377595
30MP0003950_abnormal_plasma_membrane1.59174486
31MP0008872_abnormal_physiological_respon1.52422133
32MP0003453_abnormal_keratinocyte_physiol1.51485843
33MP0003718_maternal_effect1.51081631
34MP0003786_premature_aging1.49799536
35MP0008058_abnormal_DNA_repair1.49629051
36MP0002102_abnormal_ear_morphology1.49112750
37MP0005085_abnormal_gallbladder_physiolo1.45903304
38MP0005451_abnormal_body_composition1.44971280
39MP0005023_abnormal_wound_healing1.42060128
40MP0005257_abnormal_intraocular_pressure1.34224937
41MP0010030_abnormal_orbit_morphology1.33092785
42MP0009379_abnormal_foot_pigmentation1.30340944
43MP0004381_abnormal_hair_follicle1.25888815
44MP0002282_abnormal_trachea_morphology1.25202088
45MP0000627_abnormal_mammary_gland1.23865755
46MP0004019_abnormal_vitamin_homeostasis1.23731529
47MP0006072_abnormal_retinal_apoptosis1.22058021
48MP0002160_abnormal_reproductive_system1.19441406
49MP0005389_reproductive_system_phenotype1.14941479
50MP0000372_irregular_coat_pigmentation1.14808859
51MP0003252_abnormal_bile_duct1.13725423
52MP0002876_abnormal_thyroid_physiology1.11509580
53MP0000427_abnormal_hair_cycle1.11079878
54MP0010368_abnormal_lymphatic_system1.07017560
55MP0004272_abnormal_basement_membrane1.06088811
56MP0008877_abnormal_DNA_methylation1.04598020
57MP0003937_abnormal_limbs/digits/tail_de1.02396207
58MP0003638_abnormal_response/metabolism_1.01380187
59MP0003566_abnormal_cell_adhesion0.99619061
60MP0001984_abnormal_olfaction0.95172794
61MP0001919_abnormal_reproductive_system0.92620272
62MP0003315_abnormal_perineum_morphology0.89796798
63MP0001191_abnormal_skin_condition0.89670544
64MP0003936_abnormal_reproductive_system0.86372826
65MP0003755_abnormal_palate_morphology0.85046464
66MP0001764_abnormal_homeostasis0.82556932
67MP0009780_abnormal_chondrocyte_physiolo0.81962180
68MP0010352_gastrointestinal_tract_polyps0.81783789
69MP0001881_abnormal_mammary_gland0.80839625
70MP0010094_abnormal_chromosome_stability0.78483990
71MP0005075_abnormal_melanosome_morpholog0.78107033
72MP0005197_abnormal_uvea_morphology0.76929690
73MP0003045_fibrosis0.75889651
74MP0004885_abnormal_endolymph0.75653651
75MP0000013_abnormal_adipose_tissue0.74499633
76MP0000367_abnormal_coat/_hair0.72151151
77MP0009931_abnormal_skin_appearance0.72021224
78MP0001835_abnormal_antigen_presentation0.68828444
79MP0001243_abnormal_dermal_layer0.66198392
80MP0002697_abnormal_eye_size0.65509308
81MP0002111_abnormal_tail_morphology0.62851533
82MP0008789_abnormal_olfactory_epithelium0.62595688
83MP0009785_altered_susceptibility_to0.61993092
84MP0001286_abnormal_eye_development0.61923257
85MP0006054_spinal_hemorrhage0.61449506
86MP0010386_abnormal_urinary_bladder0.61177803
87MP0001727_abnormal_embryo_implantation0.60794470
88MP0005671_abnormal_response_to0.58431749
89MP0006292_abnormal_olfactory_placode0.57467935
90MP0005084_abnormal_gallbladder_morpholo0.57206628
91MP0001340_abnormal_eyelid_morphology0.57168931
92MP0009765_abnormal_xenobiotic_induced0.57153500
93MP0002109_abnormal_limb_morphology0.55964907
94MP0000462_abnormal_digestive_system0.55927563
95MP0004264_abnormal_extraembryonic_tissu0.55839748
96MP0002006_tumorigenesis0.55619949
97MP0004142_abnormal_muscle_tone0.55457060
98MP0002736_abnormal_nociception_after0.54679028
99MP0002139_abnormal_hepatobiliary_system0.54412470
100MP0001853_heart_inflammation0.54385745

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)8.20359630
2Onycholysis (HP:0001806)6.70594499
3Milia (HP:0001056)6.68045809
4Plantar hyperkeratosis (HP:0007556)6.12972689
5Palmoplantar hyperkeratosis (HP:0000972)4.88726993
6Palmar hyperkeratosis (HP:0010765)4.64260059
7Thick nail (HP:0001805)4.24020035
8Alopecia of scalp (HP:0002293)4.13867510
9Erythroderma (HP:0001019)4.12529275
10Nail dystrophy (HP:0008404)4.12077003
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.00937277
12Atrophic scars (HP:0001075)4.00791099
13Abnormality of nail color (HP:0100643)3.98937458
14Dry hair (HP:0011359)3.60361200
15Hypotrichosis (HP:0001006)3.56270685
16Congenital ichthyosiform erythroderma (HP:0007431)3.54725213
17Sparse eyelashes (HP:0000653)3.38013137
18Aplasia cutis congenita (HP:0001057)3.13970131
19Oral leukoplakia (HP:0002745)3.04991950
20Hypoplasia of dental enamel (HP:0006297)3.04661129
21Selective tooth agenesis (HP:0001592)2.96574026
22Abnormal blistering of the skin (HP:0008066)2.91605817
23Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.88798820
24Ridged nail (HP:0001807)2.72218741
25Parakeratosis (HP:0001036)2.68178674
26Brittle hair (HP:0002299)2.67491207
27Pili torti (HP:0003777)2.65672167
28Amniotic constriction ring (HP:0009775)2.65190336
29Abnormality of placental membranes (HP:0011409)2.65190336
30Right ventricular cardiomyopathy (HP:0011663)2.63598658
31Woolly hair (HP:0002224)2.61778771
32Congenital, generalized hypertrichosis (HP:0004540)2.58251903
33Abnormal hair laboratory examination (HP:0003328)2.53516351
34Abnormality of secondary sexual hair (HP:0009888)2.52256133
35Abnormality of the axillary hair (HP:0100134)2.52256133
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.51660327
37Abnormality of alanine metabolism (HP:0010916)2.51660327
38Hyperalaninemia (HP:0003348)2.51660327
39Aplasia involving bones of the upper limbs (HP:0009823)2.50481450
40Aplasia of the phalanges of the hand (HP:0009802)2.50481450
41Aplasia involving bones of the extremities (HP:0009825)2.50481450
42Corneal erosion (HP:0200020)2.47935280
43Hypoplastic labia majora (HP:0000059)2.45069833
44Decreased subcutaneous fat (HP:0001002)2.42014980
45Conical tooth (HP:0000698)2.40862842
46Amelogenesis imperfecta (HP:0000705)2.40202533
47Xerostomia (HP:0000217)2.38900214
48Duplicated collecting system (HP:0000081)2.29553250
49Hypoplasia of the uterus (HP:0000013)2.29093120
50Fatigable weakness (HP:0003473)2.21560401
51Abnormality of the neuromuscular junction (HP:0003398)2.21560401
52Abnormality of the labia majora (HP:0012881)2.21306662
53Reduced antithrombin III activity (HP:0001976)2.19139494
54Split foot (HP:0001839)2.16451140
55Fragile skin (HP:0001030)2.14645961
56Abnormality of the renal collecting system (HP:0004742)2.12975528
57Abnormality of the distal phalanges of the toes (HP:0010182)2.10939528
58Nasolacrimal duct obstruction (HP:0000579)2.10079825
59Adrenal hypoplasia (HP:0000835)2.08084392
60Sparse scalp hair (HP:0002209)2.07035066
61Esophageal atresia (HP:0002032)2.03384474
62Palmoplantar keratoderma (HP:0000982)2.03352928
63Short middle phalanx of the 5th finger (HP:0004220)2.02885469
64Abnormality of the salivary glands (HP:0010286)2.02532345
65Popliteal pterygium (HP:0009756)2.02095922
66Aplastic anemia (HP:0001915)2.00473537
67Absent eyelashes (HP:0000561)1.99830294
68Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.99018890
69Anonychia (HP:0001798)1.98649743
70Lip pit (HP:0100267)1.97421999
71Poikiloderma (HP:0001029)1.94838950
72Squamous cell carcinoma (HP:0002860)1.94685712
73Pterygium (HP:0001059)1.93783787
74Methylmalonic acidemia (HP:0002912)1.92445501
75Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92280790
76Abnormality of the dental root (HP:0006486)1.90648579
77Taurodontia (HP:0000679)1.90648579
78Abnormality of permanent molar morphology (HP:0011071)1.90648579
79Erythema (HP:0010783)1.90465617
80Aplasia/hypoplasia of the uterus (HP:0008684)1.89071128
81Recurrent corneal erosions (HP:0000495)1.87661771
82Bilateral sensorineural hearing impairment (HP:0008619)1.87231709
83Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.84068608
84Abnormality of the dental pulp (HP:0006479)1.82996681
85Abnormality of serum amino acid levels (HP:0003112)1.79288458
86Abnormality of the phalanges of the 5th finger (HP:0004213)1.77564584
87Natal tooth (HP:0000695)1.75863257
88Abnormality of the alveolar ridges (HP:0006477)1.74712364
89Fibular aplasia (HP:0002990)1.71484691
90IgG deficiency (HP:0004315)1.71169584
91Decreased electroretinogram (ERG) amplitude (HP:0000654)1.69649148
92Abnormality of molar (HP:0011077)1.68291542
93Abnormality of molar morphology (HP:0011070)1.68291542
94Carious teeth (HP:0000670)1.67395334
95Cerebellar dysplasia (HP:0007033)1.66673110
96Abnormality of the lacrimal duct (HP:0011481)1.65915869
97Attenuation of retinal blood vessels (HP:0007843)1.65434264
98Congenital stationary night blindness (HP:0007642)1.65241818
99Abnormality of subcutaneous fat tissue (HP:0001001)1.63309670
100Sensory axonal neuropathy (HP:0003390)1.62140117

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.06363157
2MAP4K23.51714162
3PBK3.01940886
4EPHA22.88765269
5EIF2AK32.79114369
6NEK12.64795776
7MST42.57017607
8TSSK62.53500756
9ZAK2.28320655
10BUB12.15878219
11BCKDK2.11437542
12TGFBR12.09504759
13MET1.99043238
14STK241.96269005
15MKNK11.84233583
16ADRBK21.76760329
17VRK21.71083947
18RPS6KA41.70771270
19TLK11.63069747
20EIF2AK11.60514642
21NUAK11.60158938
22PASK1.59611373
23MAP3K121.56291891
24ERBB31.49028946
25ARAF1.48589607
26STK38L1.46572015
27FLT31.41464892
28TXK1.32895041
29BRSK21.30834671
30MAPKAPK51.25337770
31RPS6KB21.22026492
32TRIM281.21557781
33PDK21.20825070
34ERBB41.19093601
35SRPK11.12827999
36MAP3K91.05980900
37ITK1.02792504
38NME20.96496983
39MAPKAPK30.95481423
40CDK190.93354411
41ADRBK10.92529264
42PLK30.91956832
43MAP3K20.91301916
44EPHB20.90816771
45AURKB0.90201069
46TRPM70.90107399
47GRK10.89344063
48LATS10.85677181
49LIMK10.82949423
50STK30.82421863
51PRKCE0.78173549
52KDR0.77741427
53TAF10.76758127
54OXSR10.76728765
55MAP3K60.76691441
56WEE10.75721922
57FER0.74708198
58PLK10.71991874
59GRK60.68010074
60PRKCI0.67837093
61EIF2AK20.66843370
62NME10.65869212
63FRK0.64815907
64PNCK0.64369496
65PINK10.61864433
66CSNK1G30.61451008
67TESK10.61414165
68IGF1R0.61378012
69PIK3CG0.60953211
70RPS6KA50.58691347
71WNK40.58542941
72PAK40.57643867
73VRK10.52317886
74MAP3K40.51533373
75BCR0.50659726
76CSNK1A1L0.49321984
77CSNK1G10.48239812
78BMPR1B0.47898011
79TESK20.47830421
80CSNK1G20.47087374
81CAMK2G0.46645148
82MYLK0.45770014
83STK100.45432893
84MAP2K70.44732031
85PIM20.44222770
86JAK30.43533803
87TTK0.41897542
88CDK70.41624303
89TEC0.41538726
90CDK80.38036371
91CAMKK20.37481785
92AURKA0.37193327
93CSNK2A10.36124173
94STK390.34684550
95IKBKB0.34319859
96CAMK2D0.33499143
97BRSK10.32886330
98DAPK10.32087043
99PLK40.31960194
100CSNK2A20.29667799

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.92291952
2Ribosome_Homo sapiens_hsa030103.59493172
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86897624
4Protein export_Homo sapiens_hsa030602.66491390
5Nucleotide excision repair_Homo sapiens_hsa034202.47102911
6RNA polymerase_Homo sapiens_hsa030202.24850959
7Basal transcription factors_Homo sapiens_hsa030222.22673107
8Phototransduction_Homo sapiens_hsa047442.19993302
9Oxidative phosphorylation_Homo sapiens_hsa001901.88704288
10Mismatch repair_Homo sapiens_hsa034301.69839792
11DNA replication_Homo sapiens_hsa030301.60679768
12RNA transport_Homo sapiens_hsa030131.56126150
13Pyrimidine metabolism_Homo sapiens_hsa002401.53959175
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47445217
15Asthma_Homo sapiens_hsa053101.47105306
16Spliceosome_Homo sapiens_hsa030401.44626445
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.44409341
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42947395
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39303802
20RNA degradation_Homo sapiens_hsa030181.39110894
21ECM-receptor interaction_Homo sapiens_hsa045121.38391674
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37998208
23Linoleic acid metabolism_Homo sapiens_hsa005911.36135063
24Allograft rejection_Homo sapiens_hsa053301.34895366
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32785215
26Autoimmune thyroid disease_Homo sapiens_hsa053201.29275529
27Parkinsons disease_Homo sapiens_hsa050121.28715927
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26149906
29Histidine metabolism_Homo sapiens_hsa003401.24936631
30Base excision repair_Homo sapiens_hsa034101.24228819
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23351420
32One carbon pool by folate_Homo sapiens_hsa006701.22566336
33Type I diabetes mellitus_Homo sapiens_hsa049401.22522459
34Steroid biosynthesis_Homo sapiens_hsa001001.21660267
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21057204
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.21011904
37Chemical carcinogenesis_Homo sapiens_hsa052041.20664564
38Sulfur metabolism_Homo sapiens_hsa009201.19104921
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18179793
40Graft-versus-host disease_Homo sapiens_hsa053321.16720979
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.16038167
42Retinol metabolism_Homo sapiens_hsa008301.15049962
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11691099
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07333639
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06807983
46Nitrogen metabolism_Homo sapiens_hsa009101.05926291
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04789265
48Alzheimers disease_Homo sapiens_hsa050101.02966207
49Homologous recombination_Homo sapiens_hsa034401.01813058
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00616832
51Antigen processing and presentation_Homo sapiens_hsa046120.99724379
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98971847
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94517768
54Fatty acid elongation_Homo sapiens_hsa000620.93169269
55Purine metabolism_Homo sapiens_hsa002300.92624485
56Propanoate metabolism_Homo sapiens_hsa006400.91750409
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.89894265
58Fanconi anemia pathway_Homo sapiens_hsa034600.88078052
59Rheumatoid arthritis_Homo sapiens_hsa053230.85743891
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84657220
61Arachidonic acid metabolism_Homo sapiens_hsa005900.83836980
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78616697
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.78043009
64Tryptophan metabolism_Homo sapiens_hsa003800.77395924
65Huntingtons disease_Homo sapiens_hsa050160.75967141
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74915341
67Non-homologous end-joining_Homo sapiens_hsa034500.74605655
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74592154
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73583045
70Pyruvate metabolism_Homo sapiens_hsa006200.71377482
71Metabolic pathways_Homo sapiens_hsa011000.71209446
72Ether lipid metabolism_Homo sapiens_hsa005650.71100685
73Peroxisome_Homo sapiens_hsa041460.69996052
74beta-Alanine metabolism_Homo sapiens_hsa004100.69865283
75p53 signaling pathway_Homo sapiens_hsa041150.69271598
76Regulation of autophagy_Homo sapiens_hsa041400.67220629
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65999322
78Hematopoietic cell lineage_Homo sapiens_hsa046400.62060760
79Phenylalanine metabolism_Homo sapiens_hsa003600.59645313
80Primary immunodeficiency_Homo sapiens_hsa053400.59494720
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59067825
82Caffeine metabolism_Homo sapiens_hsa002320.57986201
83Arginine biosynthesis_Homo sapiens_hsa002200.57393759
84Hedgehog signaling pathway_Homo sapiens_hsa043400.56811700
85Biosynthesis of amino acids_Homo sapiens_hsa012300.56667214
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56551097
87Small cell lung cancer_Homo sapiens_hsa052220.53992954
88ABC transporters_Homo sapiens_hsa020100.51773522
89Glutathione metabolism_Homo sapiens_hsa004800.51621680
90Selenocompound metabolism_Homo sapiens_hsa004500.51541014
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51383104
92Basal cell carcinoma_Homo sapiens_hsa052170.50801766
93Arginine and proline metabolism_Homo sapiens_hsa003300.50354503
94Folate biosynthesis_Homo sapiens_hsa007900.46351852
95Ovarian steroidogenesis_Homo sapiens_hsa049130.46174176
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45517325
97Systemic lupus erythematosus_Homo sapiens_hsa053220.45287282
98N-Glycan biosynthesis_Homo sapiens_hsa005100.44111535
99Viral myocarditis_Homo sapiens_hsa054160.42033135
100Hippo signaling pathway_Homo sapiens_hsa043900.41730258

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