HNRNPA1P34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of isotype switching to IgG isotypes (GO:0048302)6.22946335
2regulation of chronic inflammatory response (GO:0002676)5.94913677
3DNA deamination (GO:0045006)5.90972667
4negative regulation of cell killing (GO:0031342)5.31542931
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.31542931
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.78607882
7cellular response to interleukin-15 (GO:0071350)4.73765486
8positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.61914968
9cytidine metabolic process (GO:0046087)4.55562714
10cytidine catabolic process (GO:0006216)4.55562714
11cytidine deamination (GO:0009972)4.55562714
12positive regulation of defense response to virus by host (GO:0002230)4.50106656
13negative T cell selection (GO:0043383)4.47902536
14rRNA catabolic process (GO:0016075)4.43113332
15negative thymic T cell selection (GO:0045060)4.42432771
16interferon-gamma production (GO:0032609)4.11420273
17response to interleukin-15 (GO:0070672)4.04866258
18regulation of memory T cell differentiation (GO:0043380)4.03933336
19negative regulation of T cell mediated immunity (GO:0002710)4.02445380
20regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.01027112
21activated T cell proliferation (GO:0050798)4.00219401
22regulation of immunoglobulin secretion (GO:0051023)3.89989412
23positive regulation of isotype switching (GO:0045830)3.88692948
24regulation of regulatory T cell differentiation (GO:0045589)3.84692846
25pyrimidine ribonucleoside catabolic process (GO:0046133)3.81843220
26regulation of T cell mediated cytotoxicity (GO:0001914)3.80316909
27positive regulation of immunoglobulin mediated immune response (GO:0002891)3.79988202
28positive regulation of B cell mediated immunity (GO:0002714)3.79988202
29positive regulation of immunoglobulin production (GO:0002639)3.78532793
30positive regulation of T cell mediated cytotoxicity (GO:0001916)3.77594190
31IMP biosynthetic process (GO:0006188)3.73111072
32regulation of leukocyte mediated cytotoxicity (GO:0001910)3.72488458
33positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.64805602
34positive regulation of DNA recombination (GO:0045911)3.60608854
35mast cell activation (GO:0045576)3.54787645
36exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.50196199
37positive regulation of T-helper 1 type immune response (GO:0002827)3.44915722
38regulation of isotype switching (GO:0045191)3.39639130
39RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.38989152
40positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.36419024
41regulation of cell killing (GO:0031341)3.36214632
42regulation of immunoglobulin production (GO:0002637)3.34913019
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.31775833
44positive regulation of interleukin-17 production (GO:0032740)3.29857559
45pseudouridine synthesis (GO:0001522)3.28243470
46GMP metabolic process (GO:0046037)3.27482250
47somatic hypermutation of immunoglobulin genes (GO:0016446)3.27401203
48somatic diversification of immune receptors via somatic mutation (GO:0002566)3.27401203
49positive regulation of cell killing (GO:0031343)3.25596048
50natural killer cell activation (GO:0030101)3.21584818
51tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.20507932
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.20507932
53establishment of protein localization to mitochondrial membrane (GO:0090151)3.18593176
54rRNA methylation (GO:0031167)3.16739994
55rRNA modification (GO:0000154)3.16699807
56Peyers patch development (GO:0048541)3.16603414
57mucosal-associated lymphoid tissue development (GO:0048537)3.16603414
58mast cell activation involved in immune response (GO:0002279)3.16571455
59mast cell degranulation (GO:0043303)3.16571455
60regulation of immunoglobulin mediated immune response (GO:0002889)3.14265740
61positive regulation of humoral immune response (GO:0002922)3.13520163
62regulation of defense response to virus by host (GO:0050691)3.13280732
63negative regulation of lymphocyte mediated immunity (GO:0002707)3.11070694
64regulation of gamma-delta T cell differentiation (GO:0045586)3.09236244
65positive regulation of lymphocyte mediated immunity (GO:0002708)3.08999695
66positive regulation of natural killer cell mediated immunity (GO:0002717)3.08913910
67regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.05040917
68regulation of natural killer cell mediated immunity (GO:0002715)3.05040917
69natural killer cell differentiation (GO:0001779)3.00750085
70regulation of B cell mediated immunity (GO:0002712)3.00721339
71negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.00239034
72positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.99000624
73negative regulation of alpha-beta T cell differentiation (GO:0046639)2.97922551
74DNA catabolic process, exonucleolytic (GO:0000738)2.97039190
75alpha-beta T cell differentiation (GO:0046632)2.92947812
76negative regulation of telomere maintenance (GO:0032205)2.91360308
77regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.86715313
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.85612546
79regulation of lymphocyte mediated immunity (GO:0002706)2.85509230
80IMP metabolic process (GO:0046040)2.84570270
81negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.84272453
82thymic T cell selection (GO:0045061)2.84272399
83regulation of T-helper 1 type immune response (GO:0002825)2.83330175
84lymph node development (GO:0048535)2.82880669
85tRNA processing (GO:0008033)2.82250354
86positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.78997809
87positive regulation of leukocyte mediated immunity (GO:0002705)2.76949369
88regulation of B cell receptor signaling pathway (GO:0050855)2.75849232
89positive regulation of T cell mediated immunity (GO:0002711)2.75488944
90folic acid-containing compound biosynthetic process (GO:0009396)2.71472987
91positive regulation of interferon-gamma production (GO:0032729)2.70836494
92mitochondrial respiratory chain complex I assembly (GO:0032981)2.70298228
93NADH dehydrogenase complex assembly (GO:0010257)2.70298228
94mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70298228
95CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.70251645
96positive regulation of alpha-beta T cell proliferation (GO:0046641)2.68984344
97positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.68882028
98negative regulation of alpha-beta T cell activation (GO:0046636)2.68687741
99regulation of activation of Janus kinase activity (GO:0010533)2.67988251
100negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.65825337

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.58112320
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.79770141
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.59624379
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.52775394
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.37138619
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.04180209
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.96099269
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.81190568
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.81110193
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.78118428
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76490094
12TAF15_26573619_Chip-Seq_HEK293_Human2.73207049
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59803389
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49567230
15VDR_23849224_ChIP-Seq_CD4+_Human2.47642532
16GATA3_26560356_Chip-Seq_TH2_Human2.31265584
17MYB_26560356_Chip-Seq_TH2_Human2.18207084
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06107427
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.05282539
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.97800251
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93499758
22IRF1_19129219_ChIP-ChIP_H3396_Human1.89571328
23STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88266833
24ELK1_19687146_ChIP-ChIP_HELA_Human1.87609467
25ZNF274_21170338_ChIP-Seq_K562_Hela1.87508991
26VDR_22108803_ChIP-Seq_LS180_Human1.85345621
27FOXP3_21729870_ChIP-Seq_TREG_Human1.82373115
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.79137616
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.76972665
30RUNX_20019798_ChIP-Seq_JUKART_Human1.76881488
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76733213
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.76358816
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74797760
34GATA1_22025678_ChIP-Seq_K562_Human1.73287040
35EZH2_22144423_ChIP-Seq_EOC_Human1.70702943
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57346202
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56300811
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.54945347
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51765537
40TP53_22573176_ChIP-Seq_HFKS_Human1.45503191
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43632375
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43286475
43ER_23166858_ChIP-Seq_MCF-7_Human1.42997655
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42744941
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41395384
46E2F7_22180533_ChIP-Seq_HELA_Human1.38454139
47GATA3_27048872_Chip-Seq_THYMUS_Human1.38367935
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35720844
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.35063444
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31370040
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29488983
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29488588
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23658596
54CBP_20019798_ChIP-Seq_JUKART_Human1.23658596
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23135060
56PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.22300145
57GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20630145
58MYC_18555785_ChIP-Seq_MESCs_Mouse1.19569604
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16440422
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15406711
61MYB_26560356_Chip-Seq_TH1_Human1.13392790
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.12903303
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12428111
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.12428111
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12328148
66GATA3_26560356_Chip-Seq_TH1_Human1.12103349
67BP1_19119308_ChIP-ChIP_Hs578T_Human1.11315391
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10781905
69GABP_19822575_ChIP-Seq_HepG2_Human1.08343063
70TP53_16413492_ChIP-PET_HCT116_Human1.07540275
71TCF4_22108803_ChIP-Seq_LS180_Human1.05850405
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05547918
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05254878
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05254878
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.04058438
76FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03004591
77MYC_18940864_ChIP-ChIP_HL60_Human1.02940930
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02645423
79CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02424357
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01179837
81AR_20517297_ChIP-Seq_VCAP_Human1.00797333
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99263008
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99046784
84EWS_26573619_Chip-Seq_HEK293_Human0.96168033
85ELK1_22589737_ChIP-Seq_MCF10A_Human0.96004547
86HOXB7_26014856_ChIP-Seq_BT474_Human0.95967139
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.93786028
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92900084
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92035477
90RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90764604
91FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89295892
92TAF2_19829295_ChIP-Seq_ESCs_Human0.89031973
93GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88130744
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87000922
95CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86805768
96AR_21572438_ChIP-Seq_LNCaP_Human0.85988242
97BCAT_22108803_ChIP-Seq_LS180_Human0.85480320
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85367965
99SPI1_23547873_ChIP-Seq_NB4_Human0.85240096
100POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84821095

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.22770200
2MP0001348_abnormal_lacrimal_gland3.29840304
3MP0001835_abnormal_antigen_presentation3.26442029
4MP0003763_abnormal_thymus_physiology2.81546329
5MP0000685_abnormal_immune_system2.70645555
6MP0008877_abnormal_DNA_methylation2.62210205
7MP0006072_abnormal_retinal_apoptosis2.58886122
8MP0003878_abnormal_ear_physiology2.50917986
9MP0005377_hearing/vestibular/ear_phenot2.50917986
10MP0006292_abnormal_olfactory_placode2.49624430
11MP0002148_abnormal_hypersensitivity_rea2.45152020
12MP0001346_abnormal_lacrimal_gland2.32020694
13MP0005408_hypopigmentation2.28310133
14MP0001790_abnormal_immune_system2.18814290
15MP0005387_immune_system_phenotype2.18814290
16MP0003436_decreased_susceptibility_to2.18655498
17MP0005000_abnormal_immune_tolerance2.16455640
18MP0008875_abnormal_xenobiotic_pharmacok2.15925344
19MP0008057_abnormal_DNA_replication2.15339719
20MP0009785_altered_susceptibility_to2.15272397
21MP0001800_abnormal_humoral_immune2.12860525
22MP0000372_irregular_coat_pigmentation1.93137802
23MP0001873_stomach_inflammation1.89595025
24MP0002102_abnormal_ear_morphology1.87018035
25MP0008058_abnormal_DNA_repair1.82167063
26MP0008872_abnormal_physiological_respon1.76525848
27MP0005310_abnormal_salivary_gland1.74170875
28MP0002723_abnormal_immune_serum1.73743756
29MP0002876_abnormal_thyroid_physiology1.67309415
30MP0002420_abnormal_adaptive_immunity1.65950817
31MP0002006_tumorigenesis1.65802729
32MP0001819_abnormal_immune_cell1.64845915
33MP0004147_increased_porphyrin_level1.61555257
34MP0001501_abnormal_sleep_pattern1.61136711
35MP0000703_abnormal_thymus_morphology1.58819643
36MP0005025_abnormal_response_to1.55305558
37MP0005075_abnormal_melanosome_morpholog1.48805853
38MP0002405_respiratory_system_inflammati1.48472079
39MP0002938_white_spotting1.47404876
40MP0002398_abnormal_bone_marrow1.46405517
41MP0000569_abnormal_digit_pigmentation1.45803510
42MP0009764_decreased_sensitivity_to1.44148418
43MP0002452_abnormal_antigen_presenting1.41154011
44MP0003866_abnormal_defecation1.38033242
45MP0005551_abnormal_eye_electrophysiolog1.36475376
46MP0000566_synostosis1.36273767
47MP0000716_abnormal_immune_system1.34230467
48MP0006082_CNS_inflammation1.34173127
49MP0005253_abnormal_eye_physiology1.32423358
50MP0009333_abnormal_splenocyte_physiolog1.31437953
51MP0002166_altered_tumor_susceptibility1.30661395
52MP0010155_abnormal_intestine_physiology1.29672046
53MP0000689_abnormal_spleen_morphology1.21651260
54MP0010094_abnormal_chromosome_stability1.20210735
55MP0003646_muscle_fatigue1.19325470
56MP0002722_abnormal_immune_system1.18165913
57MP0002736_abnormal_nociception_after1.14495664
58MP0001845_abnormal_inflammatory_respons1.12877418
59MP0003806_abnormal_nucleotide_metabolis1.12264910
60MP0005083_abnormal_biliary_tract1.10740866
61MP0001853_heart_inflammation1.09437679
62MP0004742_abnormal_vestibular_system1.08615809
63MP0002429_abnormal_blood_cell1.08541914
64MP0002254_reproductive_system_inflammat1.06217684
65MP0001188_hyperpigmentation1.05865695
66MP0003011_delayed_dark_adaptation1.04718157
67MP0002419_abnormal_innate_immunity1.04043609
68MP0001502_abnormal_circadian_rhythm1.02597751
69MP0006035_abnormal_mitochondrial_morpho0.99360196
70MP0001486_abnormal_startle_reflex0.99116683
71MP0003111_abnormal_nucleus_morphology0.97650493
72MP0001293_anophthalmia0.96145508
73MP0005645_abnormal_hypothalamus_physiol0.96030930
74MP0005248_abnormal_Harderian_gland0.94149808
75MP0004145_abnormal_muscle_electrophysio0.93726751
76MP0005379_endocrine/exocrine_gland_phen0.91094491
77MP0004142_abnormal_muscle_tone0.90872941
78MP0003786_premature_aging0.88114332
79MP0009697_abnormal_copulation0.83489503
80MP0002138_abnormal_hepatobiliary_system0.83292814
81MP0001919_abnormal_reproductive_system0.82993352
82MP0005085_abnormal_gallbladder_physiolo0.76619791
83MP0003252_abnormal_bile_duct0.74265016
84MP0004957_abnormal_blastocyst_morpholog0.74065775
85MP0002163_abnormal_gland_morphology0.72750302
86MP0000015_abnormal_ear_pigmentation0.71953917
87MP0000427_abnormal_hair_cycle0.70865870
88MP0004947_skin_inflammation0.70476322
89MP0001440_abnormal_grooming_behavior0.70176014
90MP0003718_maternal_effect0.70036152
91MP0002019_abnormal_tumor_incidence0.68704761
92MP0004381_abnormal_hair_follicle0.67929413
93MP0008469_abnormal_protein_level0.67815962
94MP0004084_abnormal_cardiac_muscle0.67147720
95MP0006036_abnormal_mitochondrial_physio0.66637944
96MP0000604_amyloidosis0.64582001
97MP0002396_abnormal_hematopoietic_system0.63149930
98MP0001881_abnormal_mammary_gland0.61330082
99MP0003724_increased_susceptibility_to0.61269270
100MP0001533_abnormal_skeleton_physiology0.60575727

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)4.78857599
2IgG deficiency (HP:0004315)4.77736812
3Absent rod-and cone-mediated responses on ERG (HP:0007688)4.42437915
4T lymphocytopenia (HP:0005403)4.00389493
5Abnormality of T cell number (HP:0011839)3.83362693
6Renal cortical cysts (HP:0000803)3.66209030
7Dyschromatopsia (HP:0007641)3.60353100
8Retrobulbar optic neuritis (HP:0100654)3.54947336
9Optic neuritis (HP:0100653)3.54947336
10Abnormality of the labia minora (HP:0012880)3.38053340
11Abnormal rod and cone electroretinograms (HP:0008323)3.33412022
12Abnormality of T cells (HP:0002843)3.29342017
13Myositis (HP:0100614)3.23425049
14Pancreatic cysts (HP:0001737)3.21714385
15Autoimmune hemolytic anemia (HP:0001890)3.21032412
16Visual hallucinations (HP:0002367)3.17500250
17Abnormality of eosinophils (HP:0001879)3.17045966
18Encephalitis (HP:0002383)2.94935959
19Abnormality of T cell physiology (HP:0011840)2.91778675
20Nephronophthisis (HP:0000090)2.87952524
21Keratoconjunctivitis (HP:0001096)2.87425592
22Severe combined immunodeficiency (HP:0004430)2.86920018
23Abnormality of alanine metabolism (HP:0010916)2.83253692
24Hyperalaninemia (HP:0003348)2.83253692
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.83253692
26Hypoplasia of the pons (HP:0012110)2.83156746
27Autoimmune thrombocytopenia (HP:0001973)2.81625628
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.77995606
29Orchitis (HP:0100796)2.76311353
30Short tibia (HP:0005736)2.76278983
31Stomatitis (HP:0010280)2.71174661
32Abolished electroretinogram (ERG) (HP:0000550)2.71120994
33Increased IgM level (HP:0003496)2.68185858
34Aplasia/Hypoplasia of the tibia (HP:0005772)2.66178273
35Hypoproteinemia (HP:0003075)2.64478444
36Methylmalonic acidemia (HP:0002912)2.64138587
37Conical tooth (HP:0000698)2.60660918
38Pancreatic fibrosis (HP:0100732)2.59108256
39Molar tooth sign on MRI (HP:0002419)2.57141447
40Abnormality of midbrain morphology (HP:0002418)2.57141447
41Microglossia (HP:0000171)2.55699338
42Abnormality of the pons (HP:0007361)2.54828611
43Eosinophilia (HP:0001880)2.50879691
44Abnormal biliary tract physiology (HP:0012439)2.50000439
45Bile duct proliferation (HP:0001408)2.50000439
46Keratoconjunctivitis sicca (HP:0001097)2.47267861
47Aplasia/Hypoplasia involving the musculature (HP:0001460)2.47131355
48Abnormality of the renal cortex (HP:0011035)2.45089850
49B lymphocytopenia (HP:0010976)2.39982987
50Asplenia (HP:0001746)2.37688921
51Aplasia/Hypoplasia of the tongue (HP:0010295)2.36358890
52Abnormality of B cell number (HP:0010975)2.34757354
53Vitreoretinal degeneration (HP:0000655)2.34708291
54Congenital stationary night blindness (HP:0007642)2.28031376
55Thyroiditis (HP:0100646)2.26578600
56Increased CSF lactate (HP:0002490)2.22353121
57Aplasia/Hypoplasia of the spleen (HP:0010451)2.19069132
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.18081717
59Mitochondrial inheritance (HP:0001427)2.17771609
60True hermaphroditism (HP:0010459)2.17652587
61Adrenal hypoplasia (HP:0000835)2.16630409
62Testicular atrophy (HP:0000029)2.16201234
63Prostate neoplasm (HP:0100787)2.13688474
64Stomach cancer (HP:0012126)2.10168895
65Anorexia (HP:0002039)2.09033207
66Abnormal ciliary motility (HP:0012262)2.08278604
67Abnormality of placental membranes (HP:0011409)2.07669450
68Amniotic constriction ring (HP:0009775)2.07669450
69Abnormality of the renal medulla (HP:0100957)2.07204486
70Facial hemangioma (HP:0000329)2.05670537
71Increased serum lactate (HP:0002151)2.04582866
72Combined immunodeficiency (HP:0005387)2.03024980
73Panhypogammaglobulinemia (HP:0003139)2.02894298
74Hepatocellular necrosis (HP:0001404)2.01474668
75Type II lissencephaly (HP:0007260)2.00117013
76Elevated erythrocyte sedimentation rate (HP:0003565)1.99307920
77Opisthotonus (HP:0002179)1.98523296
78Methylmalonic aciduria (HP:0012120)1.97976241
79Acute necrotizing encephalopathy (HP:0006965)1.97828493
80Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97559401
81Recurrent viral infections (HP:0004429)1.96505747
82Pigmentary retinal degeneration (HP:0001146)1.95799968
83Lipid accumulation in hepatocytes (HP:0006561)1.95464339
84Cerebellar dysplasia (HP:0007033)1.95045959
85Granulocytopenia (HP:0001913)1.92086878
86Carpal bone hypoplasia (HP:0001498)1.91121599
87Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88309943
88Alveolar cell carcinoma (HP:0006519)1.86034788
89Postaxial foot polydactyly (HP:0001830)1.84976720
90Lymphoma (HP:0002665)1.82291276
91Keratitis (HP:0000491)1.82129141
92Chronic diarrhea (HP:0002028)1.80342911
93Pulmonary infiltrates (HP:0002113)1.80114295
94Congenital, generalized hypertrichosis (HP:0004540)1.79673834
95Basal cell carcinoma (HP:0002671)1.79372004
96Increased hepatocellular lipid droplets (HP:0006565)1.77715941
97Decreased central vision (HP:0007663)1.77368734
98Gaze-evoked nystagmus (HP:0000640)1.77244600
99Acute encephalopathy (HP:0006846)1.77176201
100Recurrent fungal infections (HP:0002841)1.77079740

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.27457302
2TLK14.03160110
3TSSK63.32243925
4ZAK3.12325705
5BMPR22.94684573
6ADRBK22.59288072
7MAP3K142.29089755
8NEK12.27835197
9NUAK12.25172022
10ACVR1B2.24563366
11SRPK12.22840926
12TAOK32.17876536
13GRK62.07638011
14IKBKB2.07355561
15VRK22.03761440
16MAP4K11.92608438
17SIK21.92494597
18IKBKE1.74234561
19EIF2AK11.48011874
20JAK31.45464493
21WNK41.42125507
22AKT31.37843268
23BUB11.37611734
24PBK1.37348919
25EIF2AK31.35697108
26TRIM281.35334160
27MST41.34719976
28BCKDK1.26928018
29ALK1.21628331
30FRK1.18705679
31JAK11.14312193
32WNK31.09461196
33TBK11.08086578
34STK391.07639529
35EIF2AK21.07499314
36VRK11.07379192
37BTK1.03062531
38GRK11.00931488
39SIK30.96645482
40RIPK40.95853311
41ITK0.91014121
42EPHB10.90039692
43PRKCQ0.88067511
44FES0.87125033
45TAF10.86712253
46BMPR1B0.85602784
47OXSR10.84395152
48LCK0.83736934
49MAP4K20.82907760
50MARK30.82206187
51CAMKK20.82163672
52TEC0.81218343
53MAP2K60.80701832
54GRK70.80674809
55MAP2K20.80258720
56ATR0.79986502
57CDC70.79836865
58DYRK20.79718699
59DAPK10.79141480
60MAP3K40.76497746
61NEK20.75703781
62PIM10.73533179
63CSK0.72427300
64PIK3CG0.71855529
65LYN0.70066874
66RPS6KA50.69913967
67PASK0.69776572
68MAPKAPK30.67861359
69STK40.65944816
70PAK30.63259091
71TYK20.62268306
72SGK30.62070496
73SYK0.58933513
74IGF1R0.57490247
75PLK30.57235109
76DYRK30.56320355
77SGK20.55697029
78MAPKAPK20.53076994
79CHEK20.52971898
80KDR0.46494508
81BRAF0.45527370
82BCR0.44226289
83TGFBR10.43986142
84NEK60.43730062
85CHUK0.43322009
86INSRR0.40876089
87RPS6KB10.40215948
88CDK40.35128275
89HCK0.34692469
90SGK4940.33479197
91SGK2230.33479197
92PHKG20.33071970
93PHKG10.33071970
94RPS6KA40.32989180
95ADRBK10.31629510
96BRD40.31546705
97PLK10.31244159
98CSNK2A10.30674686
99CSNK1D0.29374233
100FYN0.29195303

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.54422190
2Proteasome_Homo sapiens_hsa030503.51479372
3Homologous recombination_Homo sapiens_hsa034402.70738920
4One carbon pool by folate_Homo sapiens_hsa006702.66567674
5Graft-versus-host disease_Homo sapiens_hsa053322.61610563
6Allograft rejection_Homo sapiens_hsa053302.59813473
7Autoimmune thyroid disease_Homo sapiens_hsa053202.42821484
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38479417
9RNA degradation_Homo sapiens_hsa030182.31860494
10Asthma_Homo sapiens_hsa053102.23060152
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.08865051
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06495421
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.04988811
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.03791420
15Antigen processing and presentation_Homo sapiens_hsa046122.02752136
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.96930632
17Basal transcription factors_Homo sapiens_hsa030221.91545608
18RNA polymerase_Homo sapiens_hsa030201.86926195
19Spliceosome_Homo sapiens_hsa030401.86370365
20Type I diabetes mellitus_Homo sapiens_hsa049401.80874232
21Mismatch repair_Homo sapiens_hsa034301.69000244
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63280431
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.61210840
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.57967971
25Protein export_Homo sapiens_hsa030601.55703468
26Caffeine metabolism_Homo sapiens_hsa002321.52600338
27Phototransduction_Homo sapiens_hsa047441.51878177
28Hematopoietic cell lineage_Homo sapiens_hsa046401.51043806
29T cell receptor signaling pathway_Homo sapiens_hsa046601.43052491
30Linoleic acid metabolism_Homo sapiens_hsa005911.42113493
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.41871204
32Fanconi anemia pathway_Homo sapiens_hsa034601.39536687
33Oxidative phosphorylation_Homo sapiens_hsa001901.38584994
34Non-homologous end-joining_Homo sapiens_hsa034501.35747788
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33110872
36DNA replication_Homo sapiens_hsa030301.32627040
37Pyrimidine metabolism_Homo sapiens_hsa002401.32263309
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21365316
39Nitrogen metabolism_Homo sapiens_hsa009101.20623208
40Measles_Homo sapiens_hsa051621.19666666
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.18697092
42Ether lipid metabolism_Homo sapiens_hsa005651.16794117
43Nucleotide excision repair_Homo sapiens_hsa034201.16768164
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12622166
45RNA transport_Homo sapiens_hsa030131.11920837
46Selenocompound metabolism_Homo sapiens_hsa004501.11767383
47Base excision repair_Homo sapiens_hsa034101.06648011
48Parkinsons disease_Homo sapiens_hsa050121.06534951
49Purine metabolism_Homo sapiens_hsa002301.02265273
50Ribosome_Homo sapiens_hsa030101.00811367
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00510813
52Vitamin digestion and absorption_Homo sapiens_hsa049770.93828104
53Huntingtons disease_Homo sapiens_hsa050160.89465781
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89247264
55Propanoate metabolism_Homo sapiens_hsa006400.89148684
56Steroid biosynthesis_Homo sapiens_hsa001000.86670485
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86361218
58Herpes simplex infection_Homo sapiens_hsa051680.85035808
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.79777507
60Retinol metabolism_Homo sapiens_hsa008300.74806555
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74584695
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74511096
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74404134
64Olfactory transduction_Homo sapiens_hsa047400.73713757
65Butanoate metabolism_Homo sapiens_hsa006500.72468957
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.70683408
67TNF signaling pathway_Homo sapiens_hsa046680.70154800
68Tryptophan metabolism_Homo sapiens_hsa003800.69324764
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63801794
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63578749
71Apoptosis_Homo sapiens_hsa042100.62755676
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59989936
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59757158
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58447857
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57785276
76Epstein-Barr virus infection_Homo sapiens_hsa051690.57285851
77Alzheimers disease_Homo sapiens_hsa050100.57091898
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.52882244
79Regulation of autophagy_Homo sapiens_hsa041400.50630257
80Fat digestion and absorption_Homo sapiens_hsa049750.47012931
81Arachidonic acid metabolism_Homo sapiens_hsa005900.46083251
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.45829104
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39690797
84Viral carcinogenesis_Homo sapiens_hsa052030.36617704
85Legionellosis_Homo sapiens_hsa051340.36040140
86Rheumatoid arthritis_Homo sapiens_hsa053230.35842406
87Cardiac muscle contraction_Homo sapiens_hsa042600.35497255
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35215889
89Sulfur metabolism_Homo sapiens_hsa009200.34282156
90African trypanosomiasis_Homo sapiens_hsa051430.32876708
91Peroxisome_Homo sapiens_hsa041460.31855837
92Metabolic pathways_Homo sapiens_hsa011000.30367482
93Mineral absorption_Homo sapiens_hsa049780.29657157
94Nicotine addiction_Homo sapiens_hsa050330.29548031
95Chemical carcinogenesis_Homo sapiens_hsa052040.29278801
96Circadian rhythm_Homo sapiens_hsa047100.27944924
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23373142
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23356716
99HTLV-I infection_Homo sapiens_hsa051660.22540575
100Leishmaniasis_Homo sapiens_hsa051400.21878655

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