

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of isotype switching to IgG isotypes (GO:0048302) | 6.22946335 |
| 2 | regulation of chronic inflammatory response (GO:0002676) | 5.94913677 |
| 3 | DNA deamination (GO:0045006) | 5.90972667 |
| 4 | negative regulation of cell killing (GO:0031342) | 5.31542931 |
| 5 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 5.31542931 |
| 6 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.78607882 |
| 7 | cellular response to interleukin-15 (GO:0071350) | 4.73765486 |
| 8 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 4.61914968 |
| 9 | cytidine metabolic process (GO:0046087) | 4.55562714 |
| 10 | cytidine catabolic process (GO:0006216) | 4.55562714 |
| 11 | cytidine deamination (GO:0009972) | 4.55562714 |
| 12 | positive regulation of defense response to virus by host (GO:0002230) | 4.50106656 |
| 13 | negative T cell selection (GO:0043383) | 4.47902536 |
| 14 | rRNA catabolic process (GO:0016075) | 4.43113332 |
| 15 | negative thymic T cell selection (GO:0045060) | 4.42432771 |
| 16 | interferon-gamma production (GO:0032609) | 4.11420273 |
| 17 | response to interleukin-15 (GO:0070672) | 4.04866258 |
| 18 | regulation of memory T cell differentiation (GO:0043380) | 4.03933336 |
| 19 | negative regulation of T cell mediated immunity (GO:0002710) | 4.02445380 |
| 20 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 4.01027112 |
| 21 | activated T cell proliferation (GO:0050798) | 4.00219401 |
| 22 | regulation of immunoglobulin secretion (GO:0051023) | 3.89989412 |
| 23 | positive regulation of isotype switching (GO:0045830) | 3.88692948 |
| 24 | regulation of regulatory T cell differentiation (GO:0045589) | 3.84692846 |
| 25 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.81843220 |
| 26 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.80316909 |
| 27 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.79988202 |
| 28 | positive regulation of B cell mediated immunity (GO:0002714) | 3.79988202 |
| 29 | positive regulation of immunoglobulin production (GO:0002639) | 3.78532793 |
| 30 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.77594190 |
| 31 | IMP biosynthetic process (GO:0006188) | 3.73111072 |
| 32 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.72488458 |
| 33 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.64805602 |
| 34 | positive regulation of DNA recombination (GO:0045911) | 3.60608854 |
| 35 | mast cell activation (GO:0045576) | 3.54787645 |
| 36 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.50196199 |
| 37 | positive regulation of T-helper 1 type immune response (GO:0002827) | 3.44915722 |
| 38 | regulation of isotype switching (GO:0045191) | 3.39639130 |
| 39 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.38989152 |
| 40 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 3.36419024 |
| 41 | regulation of cell killing (GO:0031341) | 3.36214632 |
| 42 | regulation of immunoglobulin production (GO:0002637) | 3.34913019 |
| 43 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.31775833 |
| 44 | positive regulation of interleukin-17 production (GO:0032740) | 3.29857559 |
| 45 | pseudouridine synthesis (GO:0001522) | 3.28243470 |
| 46 | GMP metabolic process (GO:0046037) | 3.27482250 |
| 47 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.27401203 |
| 48 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.27401203 |
| 49 | positive regulation of cell killing (GO:0031343) | 3.25596048 |
| 50 | natural killer cell activation (GO:0030101) | 3.21584818 |
| 51 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.20507932 |
| 52 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.20507932 |
| 53 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.18593176 |
| 54 | rRNA methylation (GO:0031167) | 3.16739994 |
| 55 | rRNA modification (GO:0000154) | 3.16699807 |
| 56 | Peyers patch development (GO:0048541) | 3.16603414 |
| 57 | mucosal-associated lymphoid tissue development (GO:0048537) | 3.16603414 |
| 58 | mast cell activation involved in immune response (GO:0002279) | 3.16571455 |
| 59 | mast cell degranulation (GO:0043303) | 3.16571455 |
| 60 | regulation of immunoglobulin mediated immune response (GO:0002889) | 3.14265740 |
| 61 | positive regulation of humoral immune response (GO:0002922) | 3.13520163 |
| 62 | regulation of defense response to virus by host (GO:0050691) | 3.13280732 |
| 63 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.11070694 |
| 64 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.09236244 |
| 65 | positive regulation of lymphocyte mediated immunity (GO:0002708) | 3.08999695 |
| 66 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 3.08913910 |
| 67 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.05040917 |
| 68 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.05040917 |
| 69 | natural killer cell differentiation (GO:0001779) | 3.00750085 |
| 70 | regulation of B cell mediated immunity (GO:0002712) | 3.00721339 |
| 71 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.00239034 |
| 72 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 2.99000624 |
| 73 | negative regulation of alpha-beta T cell differentiation (GO:0046639) | 2.97922551 |
| 74 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.97039190 |
| 75 | alpha-beta T cell differentiation (GO:0046632) | 2.92947812 |
| 76 | negative regulation of telomere maintenance (GO:0032205) | 2.91360308 |
| 77 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.86715313 |
| 78 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 2.85612546 |
| 79 | regulation of lymphocyte mediated immunity (GO:0002706) | 2.85509230 |
| 80 | IMP metabolic process (GO:0046040) | 2.84570270 |
| 81 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 2.84272453 |
| 82 | thymic T cell selection (GO:0045061) | 2.84272399 |
| 83 | regulation of T-helper 1 type immune response (GO:0002825) | 2.83330175 |
| 84 | lymph node development (GO:0048535) | 2.82880669 |
| 85 | tRNA processing (GO:0008033) | 2.82250354 |
| 86 | positive regulation of adaptive immune response based on somatic recombination of immune receptors b | 2.78997809 |
| 87 | positive regulation of leukocyte mediated immunity (GO:0002705) | 2.76949369 |
| 88 | regulation of B cell receptor signaling pathway (GO:0050855) | 2.75849232 |
| 89 | positive regulation of T cell mediated immunity (GO:0002711) | 2.75488944 |
| 90 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.71472987 |
| 91 | positive regulation of interferon-gamma production (GO:0032729) | 2.70836494 |
| 92 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.70298228 |
| 93 | NADH dehydrogenase complex assembly (GO:0010257) | 2.70298228 |
| 94 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.70298228 |
| 95 | CD4-positive, alpha-beta T cell differentiation (GO:0043367) | 2.70251645 |
| 96 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 2.68984344 |
| 97 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 2.68882028 |
| 98 | negative regulation of alpha-beta T cell activation (GO:0046636) | 2.68687741 |
| 99 | regulation of activation of Janus kinase activity (GO:0010533) | 2.67988251 |
| 100 | negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244) | 2.65825337 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.58112320 |
| 2 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.79770141 |
| 3 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.59624379 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.52775394 |
| 5 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.37138619 |
| 6 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.04180209 |
| 7 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.96099269 |
| 8 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.81190568 |
| 9 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.81110193 |
| 10 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.78118428 |
| 11 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.76490094 |
| 12 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.73207049 |
| 13 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.59803389 |
| 14 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.49567230 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.47642532 |
| 16 | GATA3_26560356_Chip-Seq_TH2_Human | 2.31265584 |
| 17 | MYB_26560356_Chip-Seq_TH2_Human | 2.18207084 |
| 18 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.06107427 |
| 19 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.05282539 |
| 20 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.97800251 |
| 21 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.93499758 |
| 22 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.89571328 |
| 23 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.88266833 |
| 24 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.87609467 |
| 25 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.87508991 |
| 26 | VDR_22108803_ChIP-Seq_LS180_Human | 1.85345621 |
| 27 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.82373115 |
| 28 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.79137616 |
| 29 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.76972665 |
| 30 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.76881488 |
| 31 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.76733213 |
| 32 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.76358816 |
| 33 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.74797760 |
| 34 | GATA1_22025678_ChIP-Seq_K562_Human | 1.73287040 |
| 35 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.70702943 |
| 36 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.57346202 |
| 37 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.56300811 |
| 38 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.54945347 |
| 39 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.51765537 |
| 40 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.45503191 |
| 41 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.43632375 |
| 42 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.43286475 |
| 43 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.42997655 |
| 44 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.42744941 |
| 45 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.41395384 |
| 46 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.38454139 |
| 47 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.38367935 |
| 48 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.35720844 |
| 49 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.35063444 |
| 50 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.31370040 |
| 51 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.29488983 |
| 52 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.29488588 |
| 53 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.23658596 |
| 54 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.23658596 |
| 55 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.23135060 |
| 56 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.22300145 |
| 57 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.20630145 |
| 58 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.19569604 |
| 59 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.16440422 |
| 60 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.15406711 |
| 61 | MYB_26560356_Chip-Seq_TH1_Human | 1.13392790 |
| 62 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.12903303 |
| 63 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.12428111 |
| 64 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.12428111 |
| 65 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.12328148 |
| 66 | GATA3_26560356_Chip-Seq_TH1_Human | 1.12103349 |
| 67 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.11315391 |
| 68 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.10781905 |
| 69 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.08343063 |
| 70 | TP53_16413492_ChIP-PET_HCT116_Human | 1.07540275 |
| 71 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.05850405 |
| 72 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.05547918 |
| 73 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.05254878 |
| 74 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.05254878 |
| 75 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.04058438 |
| 76 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.03004591 |
| 77 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.02940930 |
| 78 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.02645423 |
| 79 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.02424357 |
| 80 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.01179837 |
| 81 | AR_20517297_ChIP-Seq_VCAP_Human | 1.00797333 |
| 82 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.99263008 |
| 83 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.99046784 |
| 84 | EWS_26573619_Chip-Seq_HEK293_Human | 0.96168033 |
| 85 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.96004547 |
| 86 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.95967139 |
| 87 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.93786028 |
| 88 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.92900084 |
| 89 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.92035477 |
| 90 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.90764604 |
| 91 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 0.89295892 |
| 92 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.89031973 |
| 93 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.88130744 |
| 94 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.87000922 |
| 95 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.86805768 |
| 96 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.85988242 |
| 97 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.85480320 |
| 98 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.85367965 |
| 99 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.85240096 |
| 100 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.84821095 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005671_abnormal_response_to | 4.22770200 |
| 2 | MP0001348_abnormal_lacrimal_gland | 3.29840304 |
| 3 | MP0001835_abnormal_antigen_presentation | 3.26442029 |
| 4 | MP0003763_abnormal_thymus_physiology | 2.81546329 |
| 5 | MP0000685_abnormal_immune_system | 2.70645555 |
| 6 | MP0008877_abnormal_DNA_methylation | 2.62210205 |
| 7 | MP0006072_abnormal_retinal_apoptosis | 2.58886122 |
| 8 | MP0003878_abnormal_ear_physiology | 2.50917986 |
| 9 | MP0005377_hearing/vestibular/ear_phenot | 2.50917986 |
| 10 | MP0006292_abnormal_olfactory_placode | 2.49624430 |
| 11 | MP0002148_abnormal_hypersensitivity_rea | 2.45152020 |
| 12 | MP0001346_abnormal_lacrimal_gland | 2.32020694 |
| 13 | MP0005408_hypopigmentation | 2.28310133 |
| 14 | MP0001790_abnormal_immune_system | 2.18814290 |
| 15 | MP0005387_immune_system_phenotype | 2.18814290 |
| 16 | MP0003436_decreased_susceptibility_to | 2.18655498 |
| 17 | MP0005000_abnormal_immune_tolerance | 2.16455640 |
| 18 | MP0008875_abnormal_xenobiotic_pharmacok | 2.15925344 |
| 19 | MP0008057_abnormal_DNA_replication | 2.15339719 |
| 20 | MP0009785_altered_susceptibility_to | 2.15272397 |
| 21 | MP0001800_abnormal_humoral_immune | 2.12860525 |
| 22 | MP0000372_irregular_coat_pigmentation | 1.93137802 |
| 23 | MP0001873_stomach_inflammation | 1.89595025 |
| 24 | MP0002102_abnormal_ear_morphology | 1.87018035 |
| 25 | MP0008058_abnormal_DNA_repair | 1.82167063 |
| 26 | MP0008872_abnormal_physiological_respon | 1.76525848 |
| 27 | MP0005310_abnormal_salivary_gland | 1.74170875 |
| 28 | MP0002723_abnormal_immune_serum | 1.73743756 |
| 29 | MP0002876_abnormal_thyroid_physiology | 1.67309415 |
| 30 | MP0002420_abnormal_adaptive_immunity | 1.65950817 |
| 31 | MP0002006_tumorigenesis | 1.65802729 |
| 32 | MP0001819_abnormal_immune_cell | 1.64845915 |
| 33 | MP0004147_increased_porphyrin_level | 1.61555257 |
| 34 | MP0001501_abnormal_sleep_pattern | 1.61136711 |
| 35 | MP0000703_abnormal_thymus_morphology | 1.58819643 |
| 36 | MP0005025_abnormal_response_to | 1.55305558 |
| 37 | MP0005075_abnormal_melanosome_morpholog | 1.48805853 |
| 38 | MP0002405_respiratory_system_inflammati | 1.48472079 |
| 39 | MP0002938_white_spotting | 1.47404876 |
| 40 | MP0002398_abnormal_bone_marrow | 1.46405517 |
| 41 | MP0000569_abnormal_digit_pigmentation | 1.45803510 |
| 42 | MP0009764_decreased_sensitivity_to | 1.44148418 |
| 43 | MP0002452_abnormal_antigen_presenting | 1.41154011 |
| 44 | MP0003866_abnormal_defecation | 1.38033242 |
| 45 | MP0005551_abnormal_eye_electrophysiolog | 1.36475376 |
| 46 | MP0000566_synostosis | 1.36273767 |
| 47 | MP0000716_abnormal_immune_system | 1.34230467 |
| 48 | MP0006082_CNS_inflammation | 1.34173127 |
| 49 | MP0005253_abnormal_eye_physiology | 1.32423358 |
| 50 | MP0009333_abnormal_splenocyte_physiolog | 1.31437953 |
| 51 | MP0002166_altered_tumor_susceptibility | 1.30661395 |
| 52 | MP0010155_abnormal_intestine_physiology | 1.29672046 |
| 53 | MP0000689_abnormal_spleen_morphology | 1.21651260 |
| 54 | MP0010094_abnormal_chromosome_stability | 1.20210735 |
| 55 | MP0003646_muscle_fatigue | 1.19325470 |
| 56 | MP0002722_abnormal_immune_system | 1.18165913 |
| 57 | MP0002736_abnormal_nociception_after | 1.14495664 |
| 58 | MP0001845_abnormal_inflammatory_respons | 1.12877418 |
| 59 | MP0003806_abnormal_nucleotide_metabolis | 1.12264910 |
| 60 | MP0005083_abnormal_biliary_tract | 1.10740866 |
| 61 | MP0001853_heart_inflammation | 1.09437679 |
| 62 | MP0004742_abnormal_vestibular_system | 1.08615809 |
| 63 | MP0002429_abnormal_blood_cell | 1.08541914 |
| 64 | MP0002254_reproductive_system_inflammat | 1.06217684 |
| 65 | MP0001188_hyperpigmentation | 1.05865695 |
| 66 | MP0003011_delayed_dark_adaptation | 1.04718157 |
| 67 | MP0002419_abnormal_innate_immunity | 1.04043609 |
| 68 | MP0001502_abnormal_circadian_rhythm | 1.02597751 |
| 69 | MP0006035_abnormal_mitochondrial_morpho | 0.99360196 |
| 70 | MP0001486_abnormal_startle_reflex | 0.99116683 |
| 71 | MP0003111_abnormal_nucleus_morphology | 0.97650493 |
| 72 | MP0001293_anophthalmia | 0.96145508 |
| 73 | MP0005645_abnormal_hypothalamus_physiol | 0.96030930 |
| 74 | MP0005248_abnormal_Harderian_gland | 0.94149808 |
| 75 | MP0004145_abnormal_muscle_electrophysio | 0.93726751 |
| 76 | MP0005379_endocrine/exocrine_gland_phen | 0.91094491 |
| 77 | MP0004142_abnormal_muscle_tone | 0.90872941 |
| 78 | MP0003786_premature_aging | 0.88114332 |
| 79 | MP0009697_abnormal_copulation | 0.83489503 |
| 80 | MP0002138_abnormal_hepatobiliary_system | 0.83292814 |
| 81 | MP0001919_abnormal_reproductive_system | 0.82993352 |
| 82 | MP0005085_abnormal_gallbladder_physiolo | 0.76619791 |
| 83 | MP0003252_abnormal_bile_duct | 0.74265016 |
| 84 | MP0004957_abnormal_blastocyst_morpholog | 0.74065775 |
| 85 | MP0002163_abnormal_gland_morphology | 0.72750302 |
| 86 | MP0000015_abnormal_ear_pigmentation | 0.71953917 |
| 87 | MP0000427_abnormal_hair_cycle | 0.70865870 |
| 88 | MP0004947_skin_inflammation | 0.70476322 |
| 89 | MP0001440_abnormal_grooming_behavior | 0.70176014 |
| 90 | MP0003718_maternal_effect | 0.70036152 |
| 91 | MP0002019_abnormal_tumor_incidence | 0.68704761 |
| 92 | MP0004381_abnormal_hair_follicle | 0.67929413 |
| 93 | MP0008469_abnormal_protein_level | 0.67815962 |
| 94 | MP0004084_abnormal_cardiac_muscle | 0.67147720 |
| 95 | MP0006036_abnormal_mitochondrial_physio | 0.66637944 |
| 96 | MP0000604_amyloidosis | 0.64582001 |
| 97 | MP0002396_abnormal_hematopoietic_system | 0.63149930 |
| 98 | MP0001881_abnormal_mammary_gland | 0.61330082 |
| 99 | MP0003724_increased_susceptibility_to | 0.61269270 |
| 100 | MP0001533_abnormal_skeleton_physiology | 0.60575727 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | 3-Methylglutaconic aciduria (HP:0003535) | 4.78857599 |
| 2 | IgG deficiency (HP:0004315) | 4.77736812 |
| 3 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 4.42437915 |
| 4 | T lymphocytopenia (HP:0005403) | 4.00389493 |
| 5 | Abnormality of T cell number (HP:0011839) | 3.83362693 |
| 6 | Renal cortical cysts (HP:0000803) | 3.66209030 |
| 7 | Dyschromatopsia (HP:0007641) | 3.60353100 |
| 8 | Retrobulbar optic neuritis (HP:0100654) | 3.54947336 |
| 9 | Optic neuritis (HP:0100653) | 3.54947336 |
| 10 | Abnormality of the labia minora (HP:0012880) | 3.38053340 |
| 11 | Abnormal rod and cone electroretinograms (HP:0008323) | 3.33412022 |
| 12 | Abnormality of T cells (HP:0002843) | 3.29342017 |
| 13 | Myositis (HP:0100614) | 3.23425049 |
| 14 | Pancreatic cysts (HP:0001737) | 3.21714385 |
| 15 | Autoimmune hemolytic anemia (HP:0001890) | 3.21032412 |
| 16 | Visual hallucinations (HP:0002367) | 3.17500250 |
| 17 | Abnormality of eosinophils (HP:0001879) | 3.17045966 |
| 18 | Encephalitis (HP:0002383) | 2.94935959 |
| 19 | Abnormality of T cell physiology (HP:0011840) | 2.91778675 |
| 20 | Nephronophthisis (HP:0000090) | 2.87952524 |
| 21 | Keratoconjunctivitis (HP:0001096) | 2.87425592 |
| 22 | Severe combined immunodeficiency (HP:0004430) | 2.86920018 |
| 23 | Abnormality of alanine metabolism (HP:0010916) | 2.83253692 |
| 24 | Hyperalaninemia (HP:0003348) | 2.83253692 |
| 25 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.83253692 |
| 26 | Hypoplasia of the pons (HP:0012110) | 2.83156746 |
| 27 | Autoimmune thrombocytopenia (HP:0001973) | 2.81625628 |
| 28 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.77995606 |
| 29 | Orchitis (HP:0100796) | 2.76311353 |
| 30 | Short tibia (HP:0005736) | 2.76278983 |
| 31 | Stomatitis (HP:0010280) | 2.71174661 |
| 32 | Abolished electroretinogram (ERG) (HP:0000550) | 2.71120994 |
| 33 | Increased IgM level (HP:0003496) | 2.68185858 |
| 34 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.66178273 |
| 35 | Hypoproteinemia (HP:0003075) | 2.64478444 |
| 36 | Methylmalonic acidemia (HP:0002912) | 2.64138587 |
| 37 | Conical tooth (HP:0000698) | 2.60660918 |
| 38 | Pancreatic fibrosis (HP:0100732) | 2.59108256 |
| 39 | Molar tooth sign on MRI (HP:0002419) | 2.57141447 |
| 40 | Abnormality of midbrain morphology (HP:0002418) | 2.57141447 |
| 41 | Microglossia (HP:0000171) | 2.55699338 |
| 42 | Abnormality of the pons (HP:0007361) | 2.54828611 |
| 43 | Eosinophilia (HP:0001880) | 2.50879691 |
| 44 | Abnormal biliary tract physiology (HP:0012439) | 2.50000439 |
| 45 | Bile duct proliferation (HP:0001408) | 2.50000439 |
| 46 | Keratoconjunctivitis sicca (HP:0001097) | 2.47267861 |
| 47 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 2.47131355 |
| 48 | Abnormality of the renal cortex (HP:0011035) | 2.45089850 |
| 49 | B lymphocytopenia (HP:0010976) | 2.39982987 |
| 50 | Asplenia (HP:0001746) | 2.37688921 |
| 51 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.36358890 |
| 52 | Abnormality of B cell number (HP:0010975) | 2.34757354 |
| 53 | Vitreoretinal degeneration (HP:0000655) | 2.34708291 |
| 54 | Congenital stationary night blindness (HP:0007642) | 2.28031376 |
| 55 | Thyroiditis (HP:0100646) | 2.26578600 |
| 56 | Increased CSF lactate (HP:0002490) | 2.22353121 |
| 57 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.19069132 |
| 58 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.18081717 |
| 59 | Mitochondrial inheritance (HP:0001427) | 2.17771609 |
| 60 | True hermaphroditism (HP:0010459) | 2.17652587 |
| 61 | Adrenal hypoplasia (HP:0000835) | 2.16630409 |
| 62 | Testicular atrophy (HP:0000029) | 2.16201234 |
| 63 | Prostate neoplasm (HP:0100787) | 2.13688474 |
| 64 | Stomach cancer (HP:0012126) | 2.10168895 |
| 65 | Anorexia (HP:0002039) | 2.09033207 |
| 66 | Abnormal ciliary motility (HP:0012262) | 2.08278604 |
| 67 | Abnormality of placental membranes (HP:0011409) | 2.07669450 |
| 68 | Amniotic constriction ring (HP:0009775) | 2.07669450 |
| 69 | Abnormality of the renal medulla (HP:0100957) | 2.07204486 |
| 70 | Facial hemangioma (HP:0000329) | 2.05670537 |
| 71 | Increased serum lactate (HP:0002151) | 2.04582866 |
| 72 | Combined immunodeficiency (HP:0005387) | 2.03024980 |
| 73 | Panhypogammaglobulinemia (HP:0003139) | 2.02894298 |
| 74 | Hepatocellular necrosis (HP:0001404) | 2.01474668 |
| 75 | Type II lissencephaly (HP:0007260) | 2.00117013 |
| 76 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.99307920 |
| 77 | Opisthotonus (HP:0002179) | 1.98523296 |
| 78 | Methylmalonic aciduria (HP:0012120) | 1.97976241 |
| 79 | Acute necrotizing encephalopathy (HP:0006965) | 1.97828493 |
| 80 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.97559401 |
| 81 | Recurrent viral infections (HP:0004429) | 1.96505747 |
| 82 | Pigmentary retinal degeneration (HP:0001146) | 1.95799968 |
| 83 | Lipid accumulation in hepatocytes (HP:0006561) | 1.95464339 |
| 84 | Cerebellar dysplasia (HP:0007033) | 1.95045959 |
| 85 | Granulocytopenia (HP:0001913) | 1.92086878 |
| 86 | Carpal bone hypoplasia (HP:0001498) | 1.91121599 |
| 87 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 1.88309943 |
| 88 | Alveolar cell carcinoma (HP:0006519) | 1.86034788 |
| 89 | Postaxial foot polydactyly (HP:0001830) | 1.84976720 |
| 90 | Lymphoma (HP:0002665) | 1.82291276 |
| 91 | Keratitis (HP:0000491) | 1.82129141 |
| 92 | Chronic diarrhea (HP:0002028) | 1.80342911 |
| 93 | Pulmonary infiltrates (HP:0002113) | 1.80114295 |
| 94 | Congenital, generalized hypertrichosis (HP:0004540) | 1.79673834 |
| 95 | Basal cell carcinoma (HP:0002671) | 1.79372004 |
| 96 | Increased hepatocellular lipid droplets (HP:0006565) | 1.77715941 |
| 97 | Decreased central vision (HP:0007663) | 1.77368734 |
| 98 | Gaze-evoked nystagmus (HP:0000640) | 1.77244600 |
| 99 | Acute encephalopathy (HP:0006846) | 1.77176201 |
| 100 | Recurrent fungal infections (HP:0002841) | 1.77079740 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 5.27457302 |
| 2 | TLK1 | 4.03160110 |
| 3 | TSSK6 | 3.32243925 |
| 4 | ZAK | 3.12325705 |
| 5 | BMPR2 | 2.94684573 |
| 6 | ADRBK2 | 2.59288072 |
| 7 | MAP3K14 | 2.29089755 |
| 8 | NEK1 | 2.27835197 |
| 9 | NUAK1 | 2.25172022 |
| 10 | ACVR1B | 2.24563366 |
| 11 | SRPK1 | 2.22840926 |
| 12 | TAOK3 | 2.17876536 |
| 13 | GRK6 | 2.07638011 |
| 14 | IKBKB | 2.07355561 |
| 15 | VRK2 | 2.03761440 |
| 16 | MAP4K1 | 1.92608438 |
| 17 | SIK2 | 1.92494597 |
| 18 | IKBKE | 1.74234561 |
| 19 | EIF2AK1 | 1.48011874 |
| 20 | JAK3 | 1.45464493 |
| 21 | WNK4 | 1.42125507 |
| 22 | AKT3 | 1.37843268 |
| 23 | BUB1 | 1.37611734 |
| 24 | PBK | 1.37348919 |
| 25 | EIF2AK3 | 1.35697108 |
| 26 | TRIM28 | 1.35334160 |
| 27 | MST4 | 1.34719976 |
| 28 | BCKDK | 1.26928018 |
| 29 | ALK | 1.21628331 |
| 30 | FRK | 1.18705679 |
| 31 | JAK1 | 1.14312193 |
| 32 | WNK3 | 1.09461196 |
| 33 | TBK1 | 1.08086578 |
| 34 | STK39 | 1.07639529 |
| 35 | EIF2AK2 | 1.07499314 |
| 36 | VRK1 | 1.07379192 |
| 37 | BTK | 1.03062531 |
| 38 | GRK1 | 1.00931488 |
| 39 | SIK3 | 0.96645482 |
| 40 | RIPK4 | 0.95853311 |
| 41 | ITK | 0.91014121 |
| 42 | EPHB1 | 0.90039692 |
| 43 | PRKCQ | 0.88067511 |
| 44 | FES | 0.87125033 |
| 45 | TAF1 | 0.86712253 |
| 46 | BMPR1B | 0.85602784 |
| 47 | OXSR1 | 0.84395152 |
| 48 | LCK | 0.83736934 |
| 49 | MAP4K2 | 0.82907760 |
| 50 | MARK3 | 0.82206187 |
| 51 | CAMKK2 | 0.82163672 |
| 52 | TEC | 0.81218343 |
| 53 | MAP2K6 | 0.80701832 |
| 54 | GRK7 | 0.80674809 |
| 55 | MAP2K2 | 0.80258720 |
| 56 | ATR | 0.79986502 |
| 57 | CDC7 | 0.79836865 |
| 58 | DYRK2 | 0.79718699 |
| 59 | DAPK1 | 0.79141480 |
| 60 | MAP3K4 | 0.76497746 |
| 61 | NEK2 | 0.75703781 |
| 62 | PIM1 | 0.73533179 |
| 63 | CSK | 0.72427300 |
| 64 | PIK3CG | 0.71855529 |
| 65 | LYN | 0.70066874 |
| 66 | RPS6KA5 | 0.69913967 |
| 67 | PASK | 0.69776572 |
| 68 | MAPKAPK3 | 0.67861359 |
| 69 | STK4 | 0.65944816 |
| 70 | PAK3 | 0.63259091 |
| 71 | TYK2 | 0.62268306 |
| 72 | SGK3 | 0.62070496 |
| 73 | SYK | 0.58933513 |
| 74 | IGF1R | 0.57490247 |
| 75 | PLK3 | 0.57235109 |
| 76 | DYRK3 | 0.56320355 |
| 77 | SGK2 | 0.55697029 |
| 78 | MAPKAPK2 | 0.53076994 |
| 79 | CHEK2 | 0.52971898 |
| 80 | KDR | 0.46494508 |
| 81 | BRAF | 0.45527370 |
| 82 | BCR | 0.44226289 |
| 83 | TGFBR1 | 0.43986142 |
| 84 | NEK6 | 0.43730062 |
| 85 | CHUK | 0.43322009 |
| 86 | INSRR | 0.40876089 |
| 87 | RPS6KB1 | 0.40215948 |
| 88 | CDK4 | 0.35128275 |
| 89 | HCK | 0.34692469 |
| 90 | SGK494 | 0.33479197 |
| 91 | SGK223 | 0.33479197 |
| 92 | PHKG2 | 0.33071970 |
| 93 | PHKG1 | 0.33071970 |
| 94 | RPS6KA4 | 0.32989180 |
| 95 | ADRBK1 | 0.31629510 |
| 96 | BRD4 | 0.31546705 |
| 97 | PLK1 | 0.31244159 |
| 98 | CSNK2A1 | 0.30674686 |
| 99 | CSNK1D | 0.29374233 |
| 100 | FYN | 0.29195303 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.54422190 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 3.51479372 |
| 3 | Homologous recombination_Homo sapiens_hsa03440 | 2.70738920 |
| 4 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.66567674 |
| 5 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.61610563 |
| 6 | Allograft rejection_Homo sapiens_hsa05330 | 2.59813473 |
| 7 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.42821484 |
| 8 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.38479417 |
| 9 | RNA degradation_Homo sapiens_hsa03018 | 2.31860494 |
| 10 | Asthma_Homo sapiens_hsa05310 | 2.23060152 |
| 11 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.08865051 |
| 12 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.06495421 |
| 13 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.04988811 |
| 14 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.03791420 |
| 15 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.02752136 |
| 16 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.96930632 |
| 17 | Basal transcription factors_Homo sapiens_hsa03022 | 1.91545608 |
| 18 | RNA polymerase_Homo sapiens_hsa03020 | 1.86926195 |
| 19 | Spliceosome_Homo sapiens_hsa03040 | 1.86370365 |
| 20 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.80874232 |
| 21 | Mismatch repair_Homo sapiens_hsa03430 | 1.69000244 |
| 22 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.63280431 |
| 23 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.61210840 |
| 24 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.57967971 |
| 25 | Protein export_Homo sapiens_hsa03060 | 1.55703468 |
| 26 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.52600338 |
| 27 | Phototransduction_Homo sapiens_hsa04744 | 1.51878177 |
| 28 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.51043806 |
| 29 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.43052491 |
| 30 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.42113493 |
| 31 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.41871204 |
| 32 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.39536687 |
| 33 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.38584994 |
| 34 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.35747788 |
| 35 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.33110872 |
| 36 | DNA replication_Homo sapiens_hsa03030 | 1.32627040 |
| 37 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.32263309 |
| 38 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.21365316 |
| 39 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.20623208 |
| 40 | Measles_Homo sapiens_hsa05162 | 1.19666666 |
| 41 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.18697092 |
| 42 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.16794117 |
| 43 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.16768164 |
| 44 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.12622166 |
| 45 | RNA transport_Homo sapiens_hsa03013 | 1.11920837 |
| 46 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.11767383 |
| 47 | Base excision repair_Homo sapiens_hsa03410 | 1.06648011 |
| 48 | Parkinsons disease_Homo sapiens_hsa05012 | 1.06534951 |
| 49 | Purine metabolism_Homo sapiens_hsa00230 | 1.02265273 |
| 50 | Ribosome_Homo sapiens_hsa03010 | 1.00811367 |
| 51 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.00510813 |
| 52 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.93828104 |
| 53 | Huntingtons disease_Homo sapiens_hsa05016 | 0.89465781 |
| 54 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.89247264 |
| 55 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.89148684 |
| 56 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.86670485 |
| 57 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.86361218 |
| 58 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.85035808 |
| 59 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.79777507 |
| 60 | Retinol metabolism_Homo sapiens_hsa00830 | 0.74806555 |
| 61 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.74584695 |
| 62 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.74511096 |
| 63 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.74404134 |
| 64 | Olfactory transduction_Homo sapiens_hsa04740 | 0.73713757 |
| 65 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.72468957 |
| 66 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.70683408 |
| 67 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.70154800 |
| 68 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.69324764 |
| 69 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.63801794 |
| 70 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.63578749 |
| 71 | Apoptosis_Homo sapiens_hsa04210 | 0.62755676 |
| 72 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.59989936 |
| 73 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.59757158 |
| 74 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.58447857 |
| 75 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.57785276 |
| 76 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.57285851 |
| 77 | Alzheimers disease_Homo sapiens_hsa05010 | 0.57091898 |
| 78 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.52882244 |
| 79 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.50630257 |
| 80 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.47012931 |
| 81 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.46083251 |
| 82 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.45829104 |
| 83 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.39690797 |
| 84 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.36617704 |
| 85 | Legionellosis_Homo sapiens_hsa05134 | 0.36040140 |
| 86 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.35842406 |
| 87 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.35497255 |
| 88 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.35215889 |
| 89 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.34282156 |
| 90 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.32876708 |
| 91 | Peroxisome_Homo sapiens_hsa04146 | 0.31855837 |
| 92 | Metabolic pathways_Homo sapiens_hsa01100 | 0.30367482 |
| 93 | Mineral absorption_Homo sapiens_hsa04978 | 0.29657157 |
| 94 | Nicotine addiction_Homo sapiens_hsa05033 | 0.29548031 |
| 95 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.29278801 |
| 96 | Circadian rhythm_Homo sapiens_hsa04710 | 0.27944924 |
| 97 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.23373142 |
| 98 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.23356716 |
| 99 | HTLV-I infection_Homo sapiens_hsa05166 | 0.22540575 |
| 100 | Leishmaniasis_Homo sapiens_hsa05140 | 0.21878655 |

