HNRNPA1P35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.85791366
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.83986399
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.66338313
4ATP synthesis coupled proton transport (GO:0015986)5.44984824
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.44984824
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.45171867
7chaperone-mediated protein transport (GO:0072321)4.44477252
8ribosomal small subunit assembly (GO:0000028)4.44373324
9protein neddylation (GO:0045116)4.39335835
10respiratory electron transport chain (GO:0022904)4.15514318
11electron transport chain (GO:0022900)4.13179490
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.13051466
13proteasome assembly (GO:0043248)4.08389838
14protein complex biogenesis (GO:0070271)4.05540461
15cytidine deamination (GO:0009972)4.02310807
16cytidine metabolic process (GO:0046087)4.02310807
17cytidine catabolic process (GO:0006216)4.02310807
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.85913811
19NADH dehydrogenase complex assembly (GO:0010257)3.85913811
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.85913811
21nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.84761605
22sequestering of actin monomers (GO:0042989)3.77897351
23mitochondrial respiratory chain complex assembly (GO:0033108)3.73302861
24exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.72551277
25rRNA modification (GO:0000154)3.71043640
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59369512
27regulation of cellular amino acid metabolic process (GO:0006521)3.56868682
28RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.55997563
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.55997563
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.53746392
31signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.45659396
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.45659396
33signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.45659396
34signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.42794169
35intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.42794169
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.39535709
37translational termination (GO:0006415)3.38786923
38cotranslational protein targeting to membrane (GO:0006613)3.35538538
39pyrimidine ribonucleoside catabolic process (GO:0046133)3.35081839
40viral transcription (GO:0019083)3.34971175
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.33977314
42protein targeting to ER (GO:0045047)3.32217858
43maturation of SSU-rRNA (GO:0030490)3.29459639
44platelet dense granule organization (GO:0060155)3.27877236
45mannosylation (GO:0097502)3.27125679
46signal transduction involved in DNA integrity checkpoint (GO:0072401)3.26343578
47signal transduction involved in DNA damage checkpoint (GO:0072422)3.26343578
48signal transduction involved in cell cycle checkpoint (GO:0072395)3.25252170
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.24361502
50negative regulation of ligase activity (GO:0051352)3.24361502
51rRNA methylation (GO:0031167)3.22332828
52intracellular protein transmembrane import (GO:0044743)3.19681997
53regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.18722853
54translational elongation (GO:0006414)3.16751701
55establishment of protein localization to endoplasmic reticulum (GO:0072599)3.15168609
56protein localization to endoplasmic reticulum (GO:0070972)3.13481797
57ribosomal large subunit biogenesis (GO:0042273)3.11551448
58preassembly of GPI anchor in ER membrane (GO:0016254)3.05548521
59transcription elongation from RNA polymerase III promoter (GO:0006385)3.05254243
60termination of RNA polymerase III transcription (GO:0006386)3.05254243
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.03314161
62response to pheromone (GO:0019236)3.00689984
63translation (GO:0006412)2.97536617
64cytochrome complex assembly (GO:0017004)2.95662542
65ATP biosynthetic process (GO:0006754)2.94814855
66water-soluble vitamin biosynthetic process (GO:0042364)2.93629789
67hydrogen ion transmembrane transport (GO:1902600)2.92998455
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.92409016
69base-excision repair, AP site formation (GO:0006285)2.91513055
70GPI anchor metabolic process (GO:0006505)2.91249073
71aldehyde catabolic process (GO:0046185)2.91143870
72respiratory chain complex IV assembly (GO:0008535)2.89203454
73Arp2/3 complex-mediated actin nucleation (GO:0034314)2.89196748
74purine nucleoside triphosphate biosynthetic process (GO:0009145)2.87498771
75purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.85862528
76GPI anchor biosynthetic process (GO:0006506)2.84802507
77antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.82973556
78oxidative phosphorylation (GO:0006119)2.82158059
79negative regulation of calcium ion transport into cytosol (GO:0010523)2.81687071
80positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.80504680
81histone mRNA metabolic process (GO:0008334)2.80418783
82proton transport (GO:0015992)2.77081981
83translational initiation (GO:0006413)2.74376832
84L-fucose metabolic process (GO:0042354)2.74343683
85L-fucose catabolic process (GO:0042355)2.74343683
86fucose catabolic process (GO:0019317)2.74343683
87hydrogen transport (GO:0006818)2.71381172
88DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.70229741
89cellular protein complex disassembly (GO:0043624)2.69741086
90deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.69261588
91behavioral response to nicotine (GO:0035095)2.65495668
92neuron fate determination (GO:0048664)2.64508140
93positive regulation of ligase activity (GO:0051351)2.62674384
94negative regulation of mast cell activation (GO:0033004)2.59319826
95GTP biosynthetic process (GO:0006183)2.57513492
96actin nucleation (GO:0045010)2.57293719
97regulation of cellular amine metabolic process (GO:0033238)2.56162100
98cellular component biogenesis (GO:0044085)2.55286326
99positive regulation of cell cycle arrest (GO:0071158)2.54841277
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.54719496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.34312019
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.06689815
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.58921632
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.53988519
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.39908750
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.04319769
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95141144
8VDR_23849224_ChIP-Seq_CD4+_Human2.62368730
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60209488
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52492046
11ZNF274_21170338_ChIP-Seq_K562_Hela2.45347793
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45312179
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.40731686
14VDR_22108803_ChIP-Seq_LS180_Human2.37790473
15ELK1_19687146_ChIP-ChIP_HELA_Human2.24540565
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.23228927
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20075785
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19001468
19EWS_26573619_Chip-Seq_HEK293_Human2.15274826
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15201812
21TAF15_26573619_Chip-Seq_HEK293_Human2.06606803
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.05215356
23FOXP3_21729870_ChIP-Seq_TREG_Human2.00899551
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86083533
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83901081
26MYC_18940864_ChIP-ChIP_HL60_Human1.81087665
27EZH2_22144423_ChIP-Seq_EOC_Human1.79021944
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.74409134
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.73411667
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71740388
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69158400
32FUS_26573619_Chip-Seq_HEK293_Human1.64901867
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55042256
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52734917
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50052621
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48542927
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46555744
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46490259
39TP53_22573176_ChIP-Seq_HFKS_Human1.44881930
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43604810
41P300_19829295_ChIP-Seq_ESCs_Human1.43485409
42IGF1R_20145208_ChIP-Seq_DFB_Human1.38615721
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.38450733
44IRF1_19129219_ChIP-ChIP_H3396_Human1.37259849
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36408975
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.35420935
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33938828
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29159659
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28417354
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27050602
51ER_23166858_ChIP-Seq_MCF-7_Human1.26607078
52TTF2_22483619_ChIP-Seq_HELA_Human1.26346031
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24771014
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24017503
55AR_20517297_ChIP-Seq_VCAP_Human1.23966034
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23767536
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21889987
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.21617945
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21136151
60NANOG_19829295_ChIP-Seq_ESCs_Human1.19225388
61SOX2_19829295_ChIP-Seq_ESCs_Human1.19225388
62MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18648268
63GATA3_26560356_Chip-Seq_TH2_Human1.18042437
64DCP1A_22483619_ChIP-Seq_HELA_Human1.17357752
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.15039833
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15039833
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14871126
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14669315
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.13284471
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.12285145
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.08911504
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07619729
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07227901
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05495341
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04023902
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03570299
77HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02940777
78GABP_19822575_ChIP-Seq_HepG2_Human0.99432226
79CBP_20019798_ChIP-Seq_JUKART_Human0.98345483
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98345483
81EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98213275
82HTT_18923047_ChIP-ChIP_STHdh_Human0.97946703
83IRF8_21731497_ChIP-ChIP_J774_Mouse0.96620346
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96361686
85CBX2_27304074_Chip-Seq_ESCs_Mouse0.95377361
86PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95263933
87MYB_26560356_Chip-Seq_TH2_Human0.94413018
88CIITA_25753668_ChIP-Seq_RAJI_Human0.94120226
89FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94111236
90CRX_20693478_ChIP-Seq_RETINA_Mouse0.91765203
91NCOR_22424771_ChIP-Seq_293T_Human0.91336178
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91066256
93ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91006907
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90872277
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89071465
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.88227565
97IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87617094
98BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87204064
99EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.86899953
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86156873

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.80312961
2MP0005671_abnormal_response_to3.78111330
3MP0002102_abnormal_ear_morphology3.23860502
4MP0006292_abnormal_olfactory_placode3.21932510
5MP0001986_abnormal_taste_sensitivity3.08752676
6MP0009379_abnormal_foot_pigmentation2.92082317
7MP0006072_abnormal_retinal_apoptosis2.87745055
8MP0001835_abnormal_antigen_presentation2.64877795
9MP0008877_abnormal_DNA_methylation2.16925614
10MP0003880_abnormal_central_pattern2.09979738
11MP0005075_abnormal_melanosome_morpholog2.06150286
12MP0004142_abnormal_muscle_tone1.95238377
13MP0003806_abnormal_nucleotide_metabolis1.90196176
14MP0005084_abnormal_gallbladder_morpholo1.89989255
15MP0008995_early_reproductive_senescence1.89776730
16MP0009785_altered_susceptibility_to1.85084320
17MP0002277_abnormal_respiratory_mucosa1.81488902
18MP0008872_abnormal_physiological_respon1.73827767
19MP0000372_irregular_coat_pigmentation1.70481573
20MP0004147_increased_porphyrin_level1.69272581
21MP0001905_abnormal_dopamine_level1.63247206
22MP0005253_abnormal_eye_physiology1.63206707
23MP0001873_stomach_inflammation1.62474307
24MP0003567_abnormal_fetal_cardiomyocyte1.60586039
25MP0008058_abnormal_DNA_repair1.57778679
26MP0004742_abnormal_vestibular_system1.54991753
27MP0003786_premature_aging1.52233013
28MP0005551_abnormal_eye_electrophysiolog1.51729528
29MP0003693_abnormal_embryo_hatching1.49620330
30MP0002736_abnormal_nociception_after1.48665896
31MP0003195_calcinosis1.48091640
32MP0006276_abnormal_autonomic_nervous1.47871027
33MP0001800_abnormal_humoral_immune1.44286305
34MP0008875_abnormal_xenobiotic_pharmacok1.42602099
35MP0002234_abnormal_pharynx_morphology1.42046894
36MP0002138_abnormal_hepatobiliary_system1.40463928
37MP0002938_white_spotting1.38289311
38MP0008961_abnormal_basal_metabolism1.37653438
39MP0001529_abnormal_vocalization1.32463913
40MP0002166_altered_tumor_susceptibility1.30358909
41MP0001968_abnormal_touch/_nociception1.27233027
42MP0002006_tumorigenesis1.26683598
43MP0003878_abnormal_ear_physiology1.26140675
44MP0005377_hearing/vestibular/ear_phenot1.26140675
45MP0006036_abnormal_mitochondrial_physio1.26074379
46MP0005645_abnormal_hypothalamus_physiol1.25131029
47MP0003011_delayed_dark_adaptation1.23361147
48MP0006035_abnormal_mitochondrial_morpho1.22927719
49MP0002095_abnormal_skin_pigmentation1.19451213
50MP0005000_abnormal_immune_tolerance1.15463600
51MP0000049_abnormal_middle_ear1.13746366
52MP0005423_abnormal_somatic_nervous1.12990498
53MP0009333_abnormal_splenocyte_physiolog1.08598897
54MP0003646_muscle_fatigue1.08370552
55MP0002723_abnormal_immune_serum1.08112088
56MP0001293_anophthalmia1.03146355
57MP0002148_abnormal_hypersensitivity_rea1.02936531
58MP0005646_abnormal_pituitary_gland0.99563018
59MP0010094_abnormal_chromosome_stability0.99185376
60MP0001819_abnormal_immune_cell0.97212110
61MP0005085_abnormal_gallbladder_physiolo0.96947744
62MP0002420_abnormal_adaptive_immunity0.96658434
63MP0001919_abnormal_reproductive_system0.94222285
64MP0004133_heterotaxia0.93197506
65MP0002452_abnormal_antigen_presenting0.92070308
66MP0005387_immune_system_phenotype0.90936897
67MP0001790_abnormal_immune_system0.90936897
68MP0003937_abnormal_limbs/digits/tail_de0.90645188
69MP0000566_synostosis0.89561641
70MP0002751_abnormal_autonomic_nervous0.87577213
71MP0004957_abnormal_blastocyst_morpholog0.87040661
72MP0000685_abnormal_immune_system0.86874141
73MP0009697_abnormal_copulation0.86154247
74MP0002876_abnormal_thyroid_physiology0.84956067
75MP0002398_abnormal_bone_marrow0.83197464
76MP0000631_abnormal_neuroendocrine_gland0.81186318
77MP0002405_respiratory_system_inflammati0.80192123
78MP0000716_abnormal_immune_system0.79883392
79MP0002272_abnormal_nervous_system0.79445625
80MP0001486_abnormal_startle_reflex0.79000661
81MP0002653_abnormal_ependyma_morphology0.78497297
82MP0000689_abnormal_spleen_morphology0.78187611
83MP0002837_dystrophic_cardiac_calcinosis0.77235293
84MP0003866_abnormal_defecation0.76915840
85MP0003186_abnormal_redox_activity0.76153567
86MP0000026_abnormal_inner_ear0.75516480
87MP0005389_reproductive_system_phenotype0.73403127
88MP0003718_maternal_effect0.72826268
89MP0005410_abnormal_fertilization0.72039489
90MP0004885_abnormal_endolymph0.71657118
91MP0001485_abnormal_pinna_reflex0.71328403
92MP0000703_abnormal_thymus_morphology0.70303904
93MP0003638_abnormal_response/metabolism_0.68818451
94MP0003938_abnormal_ear_development0.68731928
95MP0002210_abnormal_sex_determination0.68532921
96MP0003137_abnormal_impulse_conducting0.67515450
97MP0005187_abnormal_penis_morphology0.67218566
98MP0004145_abnormal_muscle_electrophysio0.67008238
99MP0001119_abnormal_female_reproductive0.66554451
100MP0005025_abnormal_response_to0.66097811

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.19475672
2Mitochondrial inheritance (HP:0001427)4.13151911
3Abnormal mitochondria in muscle tissue (HP:0008316)3.81253941
4Aplastic anemia (HP:0001915)3.64438503
5Increased CSF lactate (HP:0002490)3.63860665
6Methylmalonic acidemia (HP:0002912)3.49432168
7Hepatocellular necrosis (HP:0001404)3.48376288
8Increased hepatocellular lipid droplets (HP:0006565)3.45210551
9Hypoproteinemia (HP:0003075)3.44006607
10Hypoplasia of the pons (HP:0012110)3.43310843
11Abnormality of the pons (HP:0007361)3.43141010
12Progressive macrocephaly (HP:0004481)3.41373085
133-Methylglutaconic aciduria (HP:0003535)3.41293888
14Acute encephalopathy (HP:0006846)3.34755779
15Lipid accumulation in hepatocytes (HP:0006561)3.28180522
16IgG deficiency (HP:0004315)3.22790567
17Hepatic necrosis (HP:0002605)3.19968732
18Abnormality of midbrain morphology (HP:0002418)2.98884759
19Molar tooth sign on MRI (HP:0002419)2.98884759
20Renal Fanconi syndrome (HP:0001994)2.98160388
21Methylmalonic aciduria (HP:0012120)2.89603890
22Cerebral edema (HP:0002181)2.88086714
23Congenital stationary night blindness (HP:0007642)2.79150269
24Pancreatic cysts (HP:0001737)2.78306809
25Abnormality of B cell number (HP:0010975)2.77803362
26True hermaphroditism (HP:0010459)2.62834197
27Congenital, generalized hypertrichosis (HP:0004540)2.59418734
28Type I transferrin isoform profile (HP:0003642)2.59175998
29Optic disc pallor (HP:0000543)2.58131674
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.56736829
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.56736829
32Increased intramyocellular lipid droplets (HP:0012240)2.55303764
33Pancreatic fibrosis (HP:0100732)2.55289263
34Severe combined immunodeficiency (HP:0004430)2.55228151
35Stomatitis (HP:0010280)2.52714985
36Nephronophthisis (HP:0000090)2.51905802
37Increased serum lactate (HP:0002151)2.51520147
38Abolished electroretinogram (ERG) (HP:0000550)2.49183870
39Exertional dyspnea (HP:0002875)2.44297472
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.39131413
41Abnormality of the prostate (HP:0008775)2.38749336
42Abnormal number of erythroid precursors (HP:0012131)2.36203075
43Abnormality of T cell number (HP:0011839)2.35946157
44T lymphocytopenia (HP:0005403)2.32713506
45Colon cancer (HP:0003003)2.32415563
46Reticulocytopenia (HP:0001896)2.30471888
47B lymphocytopenia (HP:0010976)2.29489458
48Increased IgM level (HP:0003496)2.26964835
49Abnormality of cells of the erythroid lineage (HP:0012130)2.26702340
50Lactic acidosis (HP:0003128)2.26354425
51Constricted visual fields (HP:0001133)2.25510775
52Macrocytic anemia (HP:0001972)2.21051950
53Renal cortical cysts (HP:0000803)2.19918528
54Thyroiditis (HP:0100646)2.18447900
55Increased muscle lipid content (HP:0009058)2.12156894
56Microvesicular hepatic steatosis (HP:0001414)2.11141360
57Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07200724
58Abnormality of the renal medulla (HP:0100957)2.05675552
59Respiratory failure (HP:0002878)2.03914130
60Exercise intolerance (HP:0003546)2.03753556
61Pancytopenia (HP:0001876)2.02387162
62Type 2 muscle fiber atrophy (HP:0003554)2.01821779
63Generalized aminoaciduria (HP:0002909)2.01632075
64Attenuation of retinal blood vessels (HP:0007843)2.00716736
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99613065
66IgM deficiency (HP:0002850)1.99425436
67Abnormality of the vitamin B12 metabolism (HP:0004341)1.98800488
68Abnormality of the renal cortex (HP:0011035)1.97591805
69Testicular atrophy (HP:0000029)1.97188378
70Abnormality of T cells (HP:0002843)1.96845567
71Lethargy (HP:0001254)1.96018996
72Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95865134
73Abnormal protein N-linked glycosylation (HP:0012347)1.95865134
74Abnormal protein glycosylation (HP:0012346)1.95865134
75Abnormal glycosylation (HP:0012345)1.95865134
76Leukodystrophy (HP:0002415)1.93366372
77Elevated erythrocyte sedimentation rate (HP:0003565)1.91013609
78Dicarboxylic aciduria (HP:0003215)1.89343506
79Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89343506
80Abnormal rod and cone electroretinograms (HP:0008323)1.88031242
81Combined immunodeficiency (HP:0005387)1.87167085
82Abnormality of vitamin B metabolism (HP:0004340)1.86341851
83Panhypogammaglobulinemia (HP:0003139)1.83877375
84Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79359690
85CNS demyelination (HP:0007305)1.78008278
86Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76785061
87Bile duct proliferation (HP:0001408)1.76268213
88Abnormal biliary tract physiology (HP:0012439)1.76268213
89Abnormality of renal resorption (HP:0011038)1.75823251
90Supernumerary spleens (HP:0009799)1.75643850
91Abnormality of eosinophils (HP:0001879)1.75405791
92Pendular nystagmus (HP:0012043)1.73171332
93Reduced antithrombin III activity (HP:0001976)1.72203180
94Carpal bone hypoplasia (HP:0001498)1.72115719
95Abnormality of the phalanges of the 2nd finger (HP:0009541)1.71989926
96Oral leukoplakia (HP:0002745)1.71978896
97Hypothermia (HP:0002045)1.71776376
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71756880
99Abnormality of alanine metabolism (HP:0010916)1.71756880
100Hyperalaninemia (HP:0003348)1.71756880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.00878026
2MAP4K22.97685882
3VRK22.93880626
4TLK12.83463534
5GRK12.77200893
6TESK22.66147266
7ZAK2.64134445
8EIF2AK32.63047041
9BCKDK2.40751049
10TAOK32.35105537
11VRK12.33106399
12ADRBK22.28449524
13KDR2.27830471
14CDK192.16397711
15ERBB32.15917488
16TAF12.08859886
17BUB11.97184222
18PASK1.74053813
19MAP3K121.68281152
20KIT1.59662843
21NUAK11.58791895
22MKNK11.52045816
23BMPR1B1.50276317
24SCYL21.48058842
25TIE11.46312750
26MST41.44297125
27DYRK21.37590484
28WNK31.36219606
29SRPK11.35276856
30TEC1.34681195
31PLK31.32782632
32TSSK61.29312210
33TNIK1.21084776
34STK161.19992010
35NME11.19000004
36FRK1.17756065
37CDC71.16191846
38MAP4K11.13664115
39ITK1.08093926
40SYK0.99344928
41TRIM280.99170444
42PLK40.98010405
43OXSR10.94475609
44PBK0.91869633
45INSRR0.90252721
46PINK10.83159141
47MKNK20.77956434
48MAPK130.77231020
49RPS6KA40.72874553
50GRK60.71542967
51IKBKB0.71223575
52EIF2AK10.70090294
53WNK40.69783921
54TNK20.69137734
55PNCK0.67471451
56CSNK1G30.67463245
57WEE10.66448944
58PLK20.65486446
59TGFBR10.63604623
60CSNK1G10.60563593
61MAP3K40.60153014
62ATR0.58810508
63CDK80.58571025
64MAPKAPK30.54581466
65DYRK30.53247444
66DAPK10.52803507
67LIMK10.52728515
68MYLK0.52081447
69PRKCE0.50506410
70IKBKE0.49687211
71NEK10.49321591
72BTK0.48982347
73AURKB0.48454042
74RPS6KA50.48416188
75IGF1R0.46722203
76PIK3CG0.46451008
77FES0.46393142
78LCK0.46015861
79CSNK1G20.45889234
80LYN0.45629504
81FLT30.45575328
82OBSCN0.45320135
83ABL20.44921323
84BCR0.44667507
85NTRK30.44324072
86CSNK1A1L0.44303908
87CSNK2A10.44201447
88EIF2AK20.43679360
89CHEK20.41654056
90JAK30.39495223
91PRKCQ0.39089034
92CLK10.38955187
93CSNK2A20.38422341
94ERBB40.38320042
95PLK10.35362545
96PIM10.34093337
97CSF1R0.33382448
98GRK50.33044583
99CSNK1A10.32749643
100PRKACA0.32490041

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.36359558
2Oxidative phosphorylation_Homo sapiens_hsa001903.75093471
3Ribosome_Homo sapiens_hsa030103.27638966
4Parkinsons disease_Homo sapiens_hsa050123.22757607
5Protein export_Homo sapiens_hsa030603.11790359
6Asthma_Homo sapiens_hsa053102.91270845
7Primary immunodeficiency_Homo sapiens_hsa053402.57484223
8Allograft rejection_Homo sapiens_hsa053302.50563914
9Autoimmune thyroid disease_Homo sapiens_hsa053202.44687403
10RNA polymerase_Homo sapiens_hsa030202.35983069
11Graft-versus-host disease_Homo sapiens_hsa053322.23823491
12Huntingtons disease_Homo sapiens_hsa050162.09835654
13Alzheimers disease_Homo sapiens_hsa050102.07884397
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.05480573
15Antigen processing and presentation_Homo sapiens_hsa046121.98283085
16Type I diabetes mellitus_Homo sapiens_hsa049401.97041568
17Homologous recombination_Homo sapiens_hsa034401.91183541
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88331038
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.71651879
20DNA replication_Homo sapiens_hsa030301.60826192
21Spliceosome_Homo sapiens_hsa030401.57877846
22Cardiac muscle contraction_Homo sapiens_hsa042601.57562464
23RNA degradation_Homo sapiens_hsa030181.53030415
24Mismatch repair_Homo sapiens_hsa034301.52975858
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48468890
26Base excision repair_Homo sapiens_hsa034101.43883733
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41419932
28Basal transcription factors_Homo sapiens_hsa030221.41365807
29Fanconi anemia pathway_Homo sapiens_hsa034601.39152508
30Phototransduction_Homo sapiens_hsa047441.38002747
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29190401
32Propanoate metabolism_Homo sapiens_hsa006401.23255960
33Rheumatoid arthritis_Homo sapiens_hsa053231.23186566
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18216347
35Pyrimidine metabolism_Homo sapiens_hsa002401.07953006
36RNA transport_Homo sapiens_hsa030131.05718742
37Hematopoietic cell lineage_Homo sapiens_hsa046401.01920801
38Non-homologous end-joining_Homo sapiens_hsa034500.96704452
39Viral myocarditis_Homo sapiens_hsa054160.96280491
40One carbon pool by folate_Homo sapiens_hsa006700.95417661
41Purine metabolism_Homo sapiens_hsa002300.95165932
42Nucleotide excision repair_Homo sapiens_hsa034200.92625372
43Peroxisome_Homo sapiens_hsa041460.86954876
44Caffeine metabolism_Homo sapiens_hsa002320.86144011
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84681496
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84471517
47Systemic lupus erythematosus_Homo sapiens_hsa053220.84122992
48Folate biosynthesis_Homo sapiens_hsa007900.82188644
49Nitrogen metabolism_Homo sapiens_hsa009100.80196765
50Linoleic acid metabolism_Homo sapiens_hsa005910.79793514
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77104530
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73849904
53Regulation of autophagy_Homo sapiens_hsa041400.72010320
54Fatty acid elongation_Homo sapiens_hsa000620.68426218
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68317231
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.65287724
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65166381
58Tryptophan metabolism_Homo sapiens_hsa003800.64054182
59Selenocompound metabolism_Homo sapiens_hsa004500.59422146
60Chemical carcinogenesis_Homo sapiens_hsa052040.58547301
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57565297
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.57342974
63Olfactory transduction_Homo sapiens_hsa047400.56989292
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56459483
65Butanoate metabolism_Homo sapiens_hsa006500.56106112
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52664072
67Metabolic pathways_Homo sapiens_hsa011000.52183138
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50166143
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49569902
70Retinol metabolism_Homo sapiens_hsa008300.49390962
71Leishmaniasis_Homo sapiens_hsa051400.48571724
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.46989688
73Staphylococcus aureus infection_Homo sapiens_hsa051500.46470587
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46164901
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44834008
76Epstein-Barr virus infection_Homo sapiens_hsa051690.44694173
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44444017
78T cell receptor signaling pathway_Homo sapiens_hsa046600.44121246
79Herpes simplex infection_Homo sapiens_hsa051680.44105672
80Pyruvate metabolism_Homo sapiens_hsa006200.43761655
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.43603077
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43509434
83Taste transduction_Homo sapiens_hsa047420.41859312
84Steroid biosynthesis_Homo sapiens_hsa001000.40573400
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40478533
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39675814
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38188966
88Collecting duct acid secretion_Homo sapiens_hsa049660.36536096
89Sulfur metabolism_Homo sapiens_hsa009200.36080464
90Nicotine addiction_Homo sapiens_hsa050330.35254994
91Arachidonic acid metabolism_Homo sapiens_hsa005900.33707981
92Glutathione metabolism_Homo sapiens_hsa004800.33403216
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.32241165
94Ether lipid metabolism_Homo sapiens_hsa005650.31734245
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29992120
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29275201
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27841593
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.25770753
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24919983
100Fatty acid degradation_Homo sapiens_hsa000710.23859373

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