HNRNPA1P36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1snRNA processing (GO:0016180)7.09102045
2protein K11-linked deubiquitination (GO:0035871)6.99763416
3snRNA metabolic process (GO:0016073)6.36558423
4rRNA catabolic process (GO:0016075)6.24248893
5peptidyl-threonine dephosphorylation (GO:0035970)6.17136090
6mitochondrion degradation (GO:0000422)6.07323310
7regulation of MHC class II biosynthetic process (GO:0045346)5.59036278
8UDP-N-acetylglucosamine metabolic process (GO:0006047)5.48962156
9rRNA modification (GO:0000154)5.45487729
10mismatch repair (GO:0006298)5.40364215
11histone H3-K4 trimethylation (GO:0080182)5.39634066
12rRNA methylation (GO:0031167)5.32493587
13purine nucleobase biosynthetic process (GO:0009113)4.87015508
14C-terminal protein lipidation (GO:0006501)4.83155347
15reciprocal DNA recombination (GO:0035825)4.76038722
16reciprocal meiotic recombination (GO:0007131)4.76038722
17acrosome assembly (GO:0001675)4.71302306
18kynurenine metabolic process (GO:0070189)4.53174417
19positive regulation of triglyceride biosynthetic process (GO:0010867)4.53009893
20cellular response to exogenous dsRNA (GO:0071360)4.35119334
21positive regulation of defense response to virus by host (GO:0002230)4.30329922
22C-terminal protein amino acid modification (GO:0018410)4.27712855
23nucleobase biosynthetic process (GO:0046112)4.26225098
24IMP biosynthetic process (GO:0006188)4.24123324
25tryptophan catabolic process (GO:0006569)4.23312583
26indole-containing compound catabolic process (GO:0042436)4.23312583
27indolalkylamine catabolic process (GO:0046218)4.23312583
28fucose catabolic process (GO:0019317)4.17455943
29L-fucose metabolic process (GO:0042354)4.17455943
30L-fucose catabolic process (GO:0042355)4.17455943
31auditory receptor cell stereocilium organization (GO:0060088)4.07799302
32positive regulation of histone H3-K4 methylation (GO:0051571)4.07170947
33phosphatidylinositol acyl-chain remodeling (GO:0036149)4.04938645
34DNA deamination (GO:0045006)4.02890416
35phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.98612287
36N-acetylneuraminate metabolic process (GO:0006054)3.96046960
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.94497891
38folic acid-containing compound biosynthetic process (GO:0009396)3.91033491
39phosphatidylserine acyl-chain remodeling (GO:0036150)3.85436281
40negative regulation of NF-kappaB import into nucleus (GO:0042347)3.80998990
41negative regulation of type I interferon production (GO:0032480)3.79321093
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.78733040
43exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.76278511
44positive regulation of mitochondrial fission (GO:0090141)3.75482510
45inner ear receptor stereocilium organization (GO:0060122)3.71632249
46positive regulation of cytokinesis (GO:0032467)3.71109285
47regulation of meiosis I (GO:0060631)3.68498756
48vesicle targeting (GO:0006903)3.67764463
49tryptophan metabolic process (GO:0006568)3.63365434
50female gamete generation (GO:0007292)3.62788659
51granulocyte differentiation (GO:0030851)3.60099494
52ncRNA catabolic process (GO:0034661)3.59781299
53carnitine metabolic process (GO:0009437)3.57897865
54IMP metabolic process (GO:0046040)3.56776625
55mitochondrial RNA metabolic process (GO:0000959)3.38790202
56regulation of nuclear cell cycle DNA replication (GO:0033262)3.33810272
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.28361527
58base-excision repair, AP site formation (GO:0006285)3.14956293
59indolalkylamine metabolic process (GO:0006586)3.14551417
60regulation of triglyceride biosynthetic process (GO:0010866)3.12565349
61negative regulation of meiosis (GO:0045835)3.11147812
62phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.08511613
63energy coupled proton transport, down electrochemical gradient (GO:0015985)3.07364502
64ATP synthesis coupled proton transport (GO:0015986)3.07364502
65interleukin-6-mediated signaling pathway (GO:0070102)3.07310496
66negative regulation of defense response to virus (GO:0050687)3.00485753
67meiosis I (GO:0007127)2.99737554
68regulation of defense response to virus by host (GO:0050691)2.98862884
69behavioral response to nicotine (GO:0035095)2.97963663
70somite development (GO:0061053)2.93256507
71regulation of mitochondrial fission (GO:0090140)2.92803249
72response to pheromone (GO:0019236)2.91392668
73peptidyl-lysine trimethylation (GO:0018023)2.90402976
74amino-acid betaine metabolic process (GO:0006577)2.90043191
75RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.89429547
76positive regulation of DNA-templated transcription, elongation (GO:0032786)2.88833518
77cellular response to dsRNA (GO:0071359)2.88827820
78mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.87979852
79positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.87979852
80interkinetic nuclear migration (GO:0022027)2.87261357
81regulation of memory T cell differentiation (GO:0043380)2.86300943
82positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.83767502
83positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.83767502
84positive regulation of mitotic sister chromatid separation (GO:1901970)2.83767502
85DNA replication checkpoint (GO:0000076)2.82610923
86negative regulation of fatty acid biosynthetic process (GO:0045717)2.81865238
87regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.81091550
88male meiosis (GO:0007140)2.80496701
89regulation of histone H3-K4 methylation (GO:0051569)2.80476798
90axonemal dynein complex assembly (GO:0070286)2.79976642
91adenosine metabolic process (GO:0046085)2.78760159
92protein-cofactor linkage (GO:0018065)2.75636785
93chaperone-mediated protein transport (GO:0072321)2.71513482
94N-acetylglucosamine metabolic process (GO:0006044)2.70624105
95positive regulation of digestive system process (GO:0060456)2.69235059
96cell fate commitment involved in formation of primary germ layer (GO:0060795)2.69059401
97positive regulation of granulocyte differentiation (GO:0030854)2.66518897
98pseudouridine synthesis (GO:0001522)2.66236891
99protein K63-linked deubiquitination (GO:0070536)2.64840647
100meiotic chromosome segregation (GO:0045132)10.0908445

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_21190229_ChIP-Seq_SHEP-21N_Human4.70207797
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.29758390
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.90850343
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.01777910
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.97855863
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.97350734
7EWS_26573619_Chip-Seq_HEK293_Human2.80990453
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69113519
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46761489
10VDR_22108803_ChIP-Seq_LS180_Human2.45147401
11ZNF274_21170338_ChIP-Seq_K562_Hela2.38517022
12TAF15_26573619_Chip-Seq_HEK293_Human2.35713398
13VDR_23849224_ChIP-Seq_CD4+_Human2.27480641
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.14742971
15MYC_18940864_ChIP-ChIP_HL60_Human2.08942953
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.07425496
17FOXP3_21729870_ChIP-Seq_TREG_Human1.99798794
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91002050
19FUS_26573619_Chip-Seq_HEK293_Human1.90281352
20GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.89298926
21EGR1_23403033_ChIP-Seq_LIVER_Mouse1.83772224
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70192705
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68475142
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67629234
25FOXA1_27270436_Chip-Seq_PROSTATE_Human1.66082928
26FOXA1_25329375_ChIP-Seq_VCAP_Human1.66082928
27GBX2_23144817_ChIP-Seq_PC3_Human1.63491206
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59741567
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.58235237
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.57002323
31TP53_22573176_ChIP-Seq_HFKS_Human1.54233528
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52899504
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52258798
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.50437996
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50367268
36AR_20517297_ChIP-Seq_VCAP_Human1.48332226
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47904694
38ER_23166858_ChIP-Seq_MCF-7_Human1.45421149
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45014845
40CBP_20019798_ChIP-Seq_JUKART_Human1.45014845
41HOXB7_26014856_ChIP-Seq_BT474_Human1.44807981
42EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.44413645
43PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.44382101
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42236749
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40316260
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40316260
47WDR5_24793694_ChIP-Seq_LNCAP_Human1.40059022
48ELK1_19687146_ChIP-ChIP_HELA_Human1.38929634
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38796145
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38692357
51BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.38638035
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37284205
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36817139
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36382359
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35302492
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.34153092
57AUTS2_25519132_ChIP-Seq_293T-REX_Human1.33026882
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32961633
59P300_19829295_ChIP-Seq_ESCs_Human1.31892520
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31487713
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.30198668
62FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30058513
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27629467
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.23569970
65DCP1A_22483619_ChIP-Seq_HELA_Human1.21255336
66TTF2_22483619_ChIP-Seq_HELA_Human1.20669990
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19247068
68TCF4_23295773_ChIP-Seq_U87_Human1.17823279
69LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17158785
70FOXH1_21741376_ChIP-Seq_EPCs_Human1.16634473
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15182439
72CDX2_22108803_ChIP-Seq_LS180_Human1.14695545
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12782090
74RBPJ_21746931_ChIP-Seq_IB4_Human1.11593690
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10201169
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08973843
77BCAT_22108803_ChIP-Seq_LS180_Human1.06743463
78IRF1_19129219_ChIP-ChIP_H3396_Human1.05454516
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03821929
80NCOR_22424771_ChIP-Seq_293T_Human1.03009833
81ETV1_20927104_ChIP-Seq_GIST48_Human1.00786111
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00690801
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99257441
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99034524
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98871487
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98263342
87MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97816809
88IGF1R_20145208_ChIP-Seq_DFB_Human0.97604957
89TCF4_18268006_ChIP-ChIP_LS174T_Human0.96933518
90KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95234946
91NANOG_19829295_ChIP-Seq_ESCs_Human0.94687412
92SOX2_19829295_ChIP-Seq_ESCs_Human0.94687412
93P53_21459846_ChIP-Seq_SAOS-2_Human0.93641092
94PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.93629835
95GATA3_21878914_ChIP-Seq_MCF-7_Human0.92437362
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92330343
97HTT_18923047_ChIP-ChIP_STHdh_Human0.92324227
98NANOG_20526341_ChIP-Seq_ESCs_Human0.91341235
99GATA3_26560356_Chip-Seq_TH2_Human0.90239428
100TFEB_21752829_ChIP-Seq_HELA_Human0.88768174

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005646_abnormal_pituitary_gland3.70134338
2MP0005310_abnormal_salivary_gland3.63288145
3MP0006072_abnormal_retinal_apoptosis3.49872154
4MP0005085_abnormal_gallbladder_physiolo3.45492685
5MP0003011_delayed_dark_adaptation3.36708055
6MP0004484_altered_response_of2.93959146
7MP0009764_decreased_sensitivity_to2.74220426
8MP0003136_yellow_coat_color2.67349699
9MP0004147_increased_porphyrin_level2.67205372
10MP0003718_maternal_effect2.35187007
11MP0005551_abnormal_eye_electrophysiolog2.33826266
12MP0003195_calcinosis2.23367321
13MP0005253_abnormal_eye_physiology2.18225847
14MP0002876_abnormal_thyroid_physiology2.15723998
15MP0008877_abnormal_DNA_methylation2.09130364
16MP0008872_abnormal_physiological_respon2.02919340
17MP0009379_abnormal_foot_pigmentation1.92181099
18MP0009780_abnormal_chondrocyte_physiolo1.91730240
19MP0008058_abnormal_DNA_repair1.91280650
20MP0005167_abnormal_blood-brain_barrier1.89245230
21MP0005365_abnormal_bile_salt1.89076729
22MP0001764_abnormal_homeostasis1.88561051
23MP0008875_abnormal_xenobiotic_pharmacok1.87499226
24MP0003646_muscle_fatigue1.86964519
25MP0004885_abnormal_endolymph1.81526728
26MP0000372_irregular_coat_pigmentation1.65033193
27MP0004742_abnormal_vestibular_system1.64909808
28MP0002928_abnormal_bile_duct1.61160129
29MP0005410_abnormal_fertilization1.59919781
30MP0002638_abnormal_pupillary_reflex1.53987295
31MP0009697_abnormal_copulation1.52631656
32MP0000631_abnormal_neuroendocrine_gland1.51603992
33MP0009643_abnormal_urine_homeostasis1.49885348
34MP0005360_urolithiasis1.48561931
35MP0004043_abnormal_pH_regulation1.47574774
36MP0009745_abnormal_behavioral_response1.47011019
37MP0002138_abnormal_hepatobiliary_system1.36790737
38MP0004215_abnormal_myocardial_fiber1.35347164
39MP0005332_abnormal_amino_acid1.31279962
40MP0003638_abnormal_response/metabolism_1.29850926
41MP0002254_reproductive_system_inflammat1.27621774
42MP0002693_abnormal_pancreas_physiology1.27172280
43MP0004957_abnormal_blastocyst_morpholog1.21507858
44MP0010094_abnormal_chromosome_stability1.18044043
45MP0005084_abnormal_gallbladder_morpholo1.13945717
46MP0006292_abnormal_olfactory_placode1.13917131
47MP0003878_abnormal_ear_physiology1.12913440
48MP0005377_hearing/vestibular/ear_phenot1.12913440
49MP0004782_abnormal_surfactant_physiolog1.11939297
50MP0005165_increased_susceptibility_to1.09314609
51MP0002127_abnormal_cardiovascular_syste1.06351272
52MP0002210_abnormal_sex_determination1.05523629
53MP0005187_abnormal_penis_morphology1.04281111
54MP0001324_abnormal_eye_pigmentation1.02281853
55MP0001502_abnormal_circadian_rhythm1.01478803
56MP0001666_abnormal_nutrient_absorption1.01377527
57MP0005671_abnormal_response_to0.99966341
58MP0002938_white_spotting0.99245783
59MP0001905_abnormal_dopamine_level0.99094268
60MP0002102_abnormal_ear_morphology0.98806229
61MP0008775_abnormal_heart_ventricle0.98453579
62MP0004133_heterotaxia0.96895290
63MP0003787_abnormal_imprinting0.96376058
64MP0006036_abnormal_mitochondrial_physio0.95378984
65MP0000230_abnormal_systemic_arterial0.92570159
66MP0005195_abnormal_posterior_eye0.91503861
67MP0000383_abnormal_hair_follicle0.90182165
68MP0002090_abnormal_vision0.87267061
69MP0004084_abnormal_cardiac_muscle0.86680850
70MP0002277_abnormal_respiratory_mucosa0.85817928
71MP0001986_abnormal_taste_sensitivity0.85453631
72MP0001501_abnormal_sleep_pattern0.85243230
73MP0002733_abnormal_thermal_nociception0.84320948
74MP0005391_vision/eye_phenotype0.83144773
75MP0001929_abnormal_gametogenesis0.82205903
76MP0001293_anophthalmia0.82004729
77MP0001188_hyperpigmentation0.81897160
78MP0001970_abnormal_pain_threshold0.79979812
79MP0002136_abnormal_kidney_physiology0.79820051
80MP0001800_abnormal_humoral_immune0.79702011
81MP0003221_abnormal_cardiomyocyte_apopto0.79544588
82MP0006276_abnormal_autonomic_nervous0.78944632
83MP0003698_abnormal_male_reproductive0.78120337
84MP0010386_abnormal_urinary_bladder0.77463004
85MP0005645_abnormal_hypothalamus_physiol0.75646173
86MP0002723_abnormal_immune_serum0.74313539
87MP0005395_other_phenotype0.73612260
88MP0005075_abnormal_melanosome_morpholog0.72454332
89MP0000653_abnormal_sex_gland0.71691117
90MP0001119_abnormal_female_reproductive0.70931107
91MP0004085_abnormal_heartbeat0.70327185
92MP0001286_abnormal_eye_development0.69196270
93MP0002557_abnormal_social/conspecific_i0.68829559
94MP0008469_abnormal_protein_level0.68721576
95MP0000427_abnormal_hair_cycle0.68578858
96MP0005647_abnormal_sex_gland0.68065483
97MP0002272_abnormal_nervous_system0.68013029
98MP0002234_abnormal_pharynx_morphology0.65456588
99MP0001968_abnormal_touch/_nociception0.64598444
100MP0002095_abnormal_skin_pigmentation0.63797201

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)5.19058609
2Abnormal rod and cone electroretinograms (HP:0008323)4.56376894
3Bile duct proliferation (HP:0001408)4.39782642
4Abnormal biliary tract physiology (HP:0012439)4.39782642
5Pigmentary retinal degeneration (HP:0001146)4.28350315
6Chronic bronchitis (HP:0004469)4.20194018
7Pancreatic cysts (HP:0001737)4.07277818
8Choroideremia (HP:0001139)4.03924572
9Congenital stationary night blindness (HP:0007642)3.95741477
10True hermaphroditism (HP:0010459)3.73661128
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.71796693
12Decreased central vision (HP:0007663)3.57150542
13Pancreatic fibrosis (HP:0100732)3.49463419
14Lipid accumulation in hepatocytes (HP:0006561)3.38273264
15Decreased circulating renin level (HP:0003351)3.37607782
16Attenuation of retinal blood vessels (HP:0007843)3.35388446
17Molar tooth sign on MRI (HP:0002419)3.09563190
18Abnormality of midbrain morphology (HP:0002418)3.09563190
19Abnormality of alanine metabolism (HP:0010916)3.00003003
20Hyperalaninemia (HP:0003348)3.00003003
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.00003003
22Thyroid-stimulating hormone excess (HP:0002925)2.99981719
23Bony spicule pigmentary retinopathy (HP:0007737)2.77745113
24Abnormality of the pons (HP:0007361)2.73041828
25Increased hepatocellular lipid droplets (HP:0006565)2.70270834
26Hypoplasia of the pons (HP:0012110)2.63887245
27Rimmed vacuoles (HP:0003805)2.57084875
28Increased neuronal autofluorescent lipopigment (HP:0002074)2.51410850
29Flat occiput (HP:0005469)2.50537341
30Abnormal respiratory motile cilium physiology (HP:0012261)2.49055956
31Central scotoma (HP:0000603)2.49045359
32Chronic hepatic failure (HP:0100626)2.40640065
33Biliary tract neoplasm (HP:0100574)2.38332591
34Constricted visual fields (HP:0001133)2.35171871
35Severe Myopia (HP:0011003)2.33828426
36Ependymoma (HP:0002888)2.27549057
37Mitochondrial inheritance (HP:0001427)2.27235071
38Cystic liver disease (HP:0006706)2.26998881
39Abnormality of the renal cortex (HP:0011035)2.25179149
40Bronchitis (HP:0012387)2.22092210
41Abnormal number of erythroid precursors (HP:0012131)2.19084326
42Type II lissencephaly (HP:0007260)2.17690997
43Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17283157
44Increased serum lactate (HP:0002151)2.17187835
45Meckel diverticulum (HP:0002245)2.16556624
46Neutropenia (HP:0001875)2.15532036
47Rhinitis (HP:0012384)2.14459966
48Hyperkalemia (HP:0002153)2.14445057
49Polydipsia (HP:0001959)2.12551967
50Abnormal drinking behavior (HP:0030082)2.12551967
51Conical tooth (HP:0000698)2.11265025
523-Methylglutaconic aciduria (HP:0003535)2.10805395
53Colon cancer (HP:0003003)2.10550904
54IgG deficiency (HP:0004315)2.10485581
55IgM deficiency (HP:0002850)2.07996429
56Increased CSF lactate (HP:0002490)2.07603607
57Hypokalemic alkalosis (HP:0001949)2.05193804
58Recurrent otitis media (HP:0000403)2.05098838
59Oral leukoplakia (HP:0002745)2.03189200
60Abnormality of the ileum (HP:0001549)2.03029824
61Furrowed tongue (HP:0000221)2.02720885
62Anencephaly (HP:0002323)2.02109441
63Congenital hepatic fibrosis (HP:0002612)1.98853756
64Nephronophthisis (HP:0000090)1.98602773
65Cerebellar dysplasia (HP:0007033)1.97929832
66Aplasia/hypoplasia of the uterus (HP:0008684)1.97695721
67Congenital, generalized hypertrichosis (HP:0004540)1.97228324
68Acute necrotizing encephalopathy (HP:0006965)1.96417936
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.95701732
70Decreased activity of mitochondrial respiratory chain (HP:0008972)1.95701732
71Confusion (HP:0001289)1.95051981
72Sclerocornea (HP:0000647)1.94932224
73Aplastic anemia (HP:0001915)1.91348861
74Respiratory difficulties (HP:0002880)1.90853072
75Hepatocellular necrosis (HP:0001404)1.90744270
76Supernumerary spleens (HP:0009799)1.89849137
77Male pseudohermaphroditism (HP:0000037)1.85296832
78Abnormality of the preputium (HP:0100587)1.84921272
79Hepatic necrosis (HP:0002605)1.84868867
80Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83781419
81Renal Fanconi syndrome (HP:0001994)1.81541055
82Abnormality of renin-angiotensin system (HP:0000847)1.81204876
83Aplasia/Hypoplasia of the uvula (HP:0010293)1.80723251
84Renal cortical cysts (HP:0000803)1.80436595
85Hyperactive renin-angiotensin system (HP:0000841)1.77924531
86Abnormality of cells of the erythroid lineage (HP:0012130)1.77574580
87Retinitis pigmentosa (HP:0000510)1.77446812
88Increased cerebral lipofuscin (HP:0011813)1.77121159
89Abolished electroretinogram (ERG) (HP:0000550)1.76825692
90Occipital encephalocele (HP:0002085)1.76053343
91Glioma (HP:0009733)1.74130855
92Polyuria (HP:0000103)1.73134896
93Clubbing of toes (HP:0100760)1.72900229
94Pendular nystagmus (HP:0012043)1.72263711
95Hypoalbuminemia (HP:0003073)1.71805606
96Abnormal albumin level (HP:0012116)1.71805606
97Lactic acidosis (HP:0003128)1.71713691
98Increased muscle lipid content (HP:0009058)1.71065940
99Opisthotonus (HP:0002179)1.71015594
100Hyperaldosteronism (HP:0000859)1.70934982

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK7.90254516
2MAP3K94.95924996
3ZAK3.43153733
4FRK3.35341995
5CAMKK23.27318493
6CAMK1D2.69451570
7PINK12.16754524
8VRK22.12603526
9NUAK12.02464854
10MAPKAPK51.92614773
11SRPK11.87591093
12GRK11.85686118
13DYRK31.78696016
14TLK11.74407913
15VRK11.65995586
16WNK31.62496191
17MST41.61843718
18CAMK1G1.58250051
19TAOK31.51013360
20MKNK11.49496275
21ADRBK21.45274430
22TAF11.41502739
23RPS6KA41.35390695
24PDK11.31931616
25TNK21.31666027
26DYRK21.24999627
27PDPK11.23045529
28WNK41.20996017
29TSSK61.17687939
30TXK1.14394938
31CDC71.12211168
32BUB11.10461358
33CAMK41.03974577
34MKNK21.00167717
35MAPKAPK30.98328851
36OXSR10.96029795
37PLK30.93551709
38NEK10.91514244
39MAP4K20.86038157
40STK38L0.85273529
41HIPK20.85113886
42EPHA40.84252378
43DAPK20.83197302
44MELK0.81043685
45ITK0.80261415
46CAMKK10.79415932
47MUSK0.77134302
48RPS6KA50.76176125
49STK160.74196094
50TESK20.73987029
51KIT0.73673350
52MARK30.72069361
53IKBKB0.69839053
54STK390.67668678
55ATR0.64405104
56FLT30.64327463
57PASK0.62204215
58BMPR1B0.60415084
59ALK0.59250981
60PLK40.56862827
61CSNK1E0.55568731
62PRKCQ0.53436541
63ACVR1B0.51260467
64WEE10.51151365
65PLK10.50781054
66ADRBK10.50627252
67PBK0.50602872
68AURKB0.49433858
69LYN0.46628920
70CDK190.46538156
71NLK0.45710793
72EIF2AK30.44884286
73PRKCE0.44734447
74CSNK2A20.44080378
75MAPK150.42981672
76CDK90.42448963
77INSRR0.42429971
78TIE10.41934820
79TTK0.39132529
80TEC0.39043887
81GSK3A0.38357259
82ERBB20.36570341
83CDK80.32632522
84MAP3K40.31780256
85CAMK10.31338910
86MAP2K60.29924211
87TRIM280.29556484
88RPS6KA60.27576429
89TGFBR10.26063235
90MAP3K50.25158624
91TNIK0.24612400
92PRKCG0.24567072
93BRSK20.23857274
94PRKG10.23612316
95PIM10.23579779
96CHEK20.23172984
97PRKG20.23147647
98NEK20.21919439
99PRKCI0.21866753
100TRPM70.21392426

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of autophagy_Homo sapiens_hsa041403.69600452
2Propanoate metabolism_Homo sapiens_hsa006403.29840456
3Linoleic acid metabolism_Homo sapiens_hsa005913.12389962
4One carbon pool by folate_Homo sapiens_hsa006703.09128569
5Caffeine metabolism_Homo sapiens_hsa002322.90041234
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.81407504
7Proteasome_Homo sapiens_hsa030502.71249440
8Ribosome_Homo sapiens_hsa030102.32028256
9Mismatch repair_Homo sapiens_hsa034302.29593110
10Pyruvate metabolism_Homo sapiens_hsa006202.07990478
11Cysteine and methionine metabolism_Homo sapiens_hsa002702.06687737
12Oxidative phosphorylation_Homo sapiens_hsa001902.05564712
13RNA polymerase_Homo sapiens_hsa030201.96529471
14Tryptophan metabolism_Homo sapiens_hsa003801.94648289
15Selenocompound metabolism_Homo sapiens_hsa004501.88126782
16Phototransduction_Homo sapiens_hsa047441.86187755
17Basal transcription factors_Homo sapiens_hsa030221.83198549
18Sulfur metabolism_Homo sapiens_hsa009201.79164439
19RNA degradation_Homo sapiens_hsa030181.73147473
20Homologous recombination_Homo sapiens_hsa034401.71817076
21Protein export_Homo sapiens_hsa030601.69715095
22Fatty acid degradation_Homo sapiens_hsa000711.68871679
23Parkinsons disease_Homo sapiens_hsa050121.66654864
24Ether lipid metabolism_Homo sapiens_hsa005651.52064039
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43825051
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.36812394
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36274485
28Asthma_Homo sapiens_hsa053101.33722996
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32541352
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17855548
31Huntingtons disease_Homo sapiens_hsa050161.17046483
32Nitrogen metabolism_Homo sapiens_hsa009101.16836593
33Primary immunodeficiency_Homo sapiens_hsa053401.16592935
34Arachidonic acid metabolism_Homo sapiens_hsa005901.15754095
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11232581
36Fatty acid metabolism_Homo sapiens_hsa012121.08701486
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07385315
38Fanconi anemia pathway_Homo sapiens_hsa034601.06520017
39Allograft rejection_Homo sapiens_hsa053301.00022502
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99792048
41Primary bile acid biosynthesis_Homo sapiens_hsa001200.96863078
42Alzheimers disease_Homo sapiens_hsa050100.93776258
43Purine metabolism_Homo sapiens_hsa002300.93577565
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93365703
45Spliceosome_Homo sapiens_hsa030400.92425021
46Cardiac muscle contraction_Homo sapiens_hsa042600.86781740
47RNA transport_Homo sapiens_hsa030130.86047857
48Sulfur relay system_Homo sapiens_hsa041220.85451997
49Fat digestion and absorption_Homo sapiens_hsa049750.85422011
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83974600
51Butanoate metabolism_Homo sapiens_hsa006500.83849309
52Autoimmune thyroid disease_Homo sapiens_hsa053200.83110011
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82959620
54Staphylococcus aureus infection_Homo sapiens_hsa051500.81825889
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80545302
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.80348091
57Retinol metabolism_Homo sapiens_hsa008300.79216741
58Pyrimidine metabolism_Homo sapiens_hsa002400.79178682
59Ovarian steroidogenesis_Homo sapiens_hsa049130.77999275
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74631624
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73753291
62Steroid biosynthesis_Homo sapiens_hsa001000.73307058
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71617155
64DNA replication_Homo sapiens_hsa030300.71280188
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.69340736
66Base excision repair_Homo sapiens_hsa034100.65162616
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65066182
68Morphine addiction_Homo sapiens_hsa050320.64892490
69Metabolic pathways_Homo sapiens_hsa011000.62661330
70PPAR signaling pathway_Homo sapiens_hsa033200.60125581
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59219309
72Arginine and proline metabolism_Homo sapiens_hsa003300.58788826
73Non-homologous end-joining_Homo sapiens_hsa034500.58737762
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58096704
75Lysine degradation_Homo sapiens_hsa003100.56478010
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56244496
77Chemical carcinogenesis_Homo sapiens_hsa052040.52941611
78Serotonergic synapse_Homo sapiens_hsa047260.51978325
79Taste transduction_Homo sapiens_hsa047420.50998029
80Cell cycle_Homo sapiens_hsa041100.48872937
81Arginine biosynthesis_Homo sapiens_hsa002200.48288360
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.47914383
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45517106
84Olfactory transduction_Homo sapiens_hsa047400.43519414
85Glutathione metabolism_Homo sapiens_hsa004800.42773592
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42078591
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39764209
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39561991
89Nucleotide excision repair_Homo sapiens_hsa034200.39313957
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38187024
91FoxO signaling pathway_Homo sapiens_hsa040680.36981674
92Nicotine addiction_Homo sapiens_hsa050330.35420617
93Graft-versus-host disease_Homo sapiens_hsa053320.34977315
94Glucagon signaling pathway_Homo sapiens_hsa049220.33843231
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32159035
96Type I diabetes mellitus_Homo sapiens_hsa049400.31620993
97Antigen processing and presentation_Homo sapiens_hsa046120.29612084
98Hematopoietic cell lineage_Homo sapiens_hsa046400.29367009
99Mineral absorption_Homo sapiens_hsa049780.28961737
100Peroxisome_Homo sapiens_hsa041460.28794782

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