ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	snRNA processing (GO:0016180)	7.09102045
2	protein K11-linked deubiquitination (GO:0035871)	6.99763416
3	snRNA metabolic process (GO:0016073)	6.36558423
4	rRNA catabolic process (GO:0016075)	6.24248893
5	peptidyl-threonine dephosphorylation (GO:0035970)	6.17136090
6	mitochondrion degradation (GO:0000422)	6.07323310
7	regulation of MHC class II biosynthetic process (GO:0045346)	5.59036278
8	UDP-N-acetylglucosamine metabolic process (GO:0006047)	5.48962156
9	rRNA modification (GO:0000154)	5.45487729
10	mismatch repair (GO:0006298)	5.40364215
11	histone H3-K4 trimethylation (GO:0080182)	5.39634066
12	rRNA methylation (GO:0031167)	5.32493587
13	purine nucleobase biosynthetic process (GO:0009113)	4.87015508
14	C-terminal protein lipidation (GO:0006501)	4.83155347
15	reciprocal DNA recombination (GO:0035825)	4.76038722
16	reciprocal meiotic recombination (GO:0007131)	4.76038722
17	acrosome assembly (GO:0001675)	4.71302306
18	kynurenine metabolic process (GO:0070189)	4.53174417
19	positive regulation of triglyceride biosynthetic process (GO:0010867)	4.53009893
20	cellular response to exogenous dsRNA (GO:0071360)	4.35119334
21	positive regulation of defense response to virus by host (GO:0002230)	4.30329922
22	C-terminal protein amino acid modification (GO:0018410)	4.27712855
23	nucleobase biosynthetic process (GO:0046112)	4.26225098
24	IMP biosynthetic process (GO:0006188)	4.24123324
25	indole-containing compound catabolic process (GO:0042436)	4.23312583
26	indolalkylamine catabolic process (GO:0046218)	4.23312583
27	tryptophan catabolic process (GO:0006569)	4.23312583
28	fucose catabolic process (GO:0019317)	4.17455943
29	L-fucose metabolic process (GO:0042354)	4.17455943
30	L-fucose catabolic process (GO:0042355)	4.17455943
31	auditory receptor cell stereocilium organization (GO:0060088)	4.07799302
32	positive regulation of histone H3-K4 methylation (GO:0051571)	4.07170947
33	phosphatidylinositol acyl-chain remodeling (GO:0036149)	4.04938645
34	DNA deamination (GO:0045006)	4.02890416
35	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.98612287
36	N-acetylneuraminate metabolic process (GO:0006054)	3.96046960
37	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.94497891
38	folic acid-containing compound biosynthetic process (GO:0009396)	3.91033491
39	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.85436281
40	negative regulation of NF-kappaB import into nucleus (GO:0042347)	3.80998990
41	negative regulation of type I interferon production (GO:0032480)	3.79321093
42	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.78733040
43	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.76278511
44	positive regulation of mitochondrial fission (GO:0090141)	3.75482510
45	inner ear receptor stereocilium organization (GO:0060122)	3.71632249
46	positive regulation of cytokinesis (GO:0032467)	3.71109285
47	regulation of meiosis I (GO:0060631)	3.68498756
48	vesicle targeting (GO:0006903)	3.67764463
49	tryptophan metabolic process (GO:0006568)	3.63365434
50	female gamete generation (GO:0007292)	3.62788659
51	granulocyte differentiation (GO:0030851)	3.60099494
52	ncRNA catabolic process (GO:0034661)	3.59781299
53	carnitine metabolic process (GO:0009437)	3.57897865
54	IMP metabolic process (GO:0046040)	3.56776625
55	mitochondrial RNA metabolic process (GO:0000959)	3.38790202
56	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.33810272
57	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.28361527
58	base-excision repair, AP site formation (GO:0006285)	3.14956293
59	indolalkylamine metabolic process (GO:0006586)	3.14551417
60	regulation of triglyceride biosynthetic process (GO:0010866)	3.12565349
61	negative regulation of meiosis (GO:0045835)	3.11147812
62	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.08511613
63	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.07364502
64	ATP synthesis coupled proton transport (GO:0015986)	3.07364502
65	interleukin-6-mediated signaling pathway (GO:0070102)	3.07310496
66	negative regulation of defense response to virus (GO:0050687)	3.00485753
67	meiosis I (GO:0007127)	2.99737554
68	regulation of defense response to virus by host (GO:0050691)	2.98862884
69	behavioral response to nicotine (GO:0035095)	2.97963663
70	somite development (GO:0061053)	2.93256507
71	regulation of mitochondrial fission (GO:0090140)	2.92803249
72	response to pheromone (GO:0019236)	2.91392668
73	peptidyl-lysine trimethylation (GO:0018023)	2.90402976
74	amino-acid betaine metabolic process (GO:0006577)	2.90043191
75	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.89429547
76	positive regulation of DNA-templated transcription, elongation (GO:0032786)	2.88833518
77	cellular response to dsRNA (GO:0071359)	2.88827820
78	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.87979852
79	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.87979852
80	interkinetic nuclear migration (GO:0022027)	2.87261357
81	regulation of memory T cell differentiation (GO:0043380)	2.86300943
82	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.83767502
83	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.83767502
84	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.83767502
85	DNA replication checkpoint (GO:0000076)	2.82610923
86	negative regulation of fatty acid biosynthetic process (GO:0045717)	2.81865238
87	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.81091550
88	male meiosis (GO:0007140)	2.80496701
89	regulation of histone H3-K4 methylation (GO:0051569)	2.80476798
90	axonemal dynein complex assembly (GO:0070286)	2.79976642
91	adenosine metabolic process (GO:0046085)	2.78760159
92	protein-cofactor linkage (GO:0018065)	2.75636785
93	chaperone-mediated protein transport (GO:0072321)	2.71513482
94	N-acetylglucosamine metabolic process (GO:0006044)	2.70624105
95	positive regulation of digestive system process (GO:0060456)	2.69235059
96	cell fate commitment involved in formation of primary germ layer (GO:0060795)	2.69059401
97	positive regulation of granulocyte differentiation (GO:0030854)	2.66518897
98	pseudouridine synthesis (GO:0001522)	2.66236891
99	protein K63-linked deubiquitination (GO:0070536)	2.64840647
100	meiotic chromosome segregation (GO:0045132)	10.0908445

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	4.70207797
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.29758390
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.90850343
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.01777910
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.97855863
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.97350734
7	EWS_26573619_Chip-Seq_HEK293_Human	2.80990453
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.69113519
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.46761489
10	VDR_22108803_ChIP-Seq_LS180_Human	2.45147401
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.38517022
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.35713398
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.27480641
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14742971
15	MYC_18940864_ChIP-ChIP_HL60_Human	2.08942953
16	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.07425496
17	FOXP3_21729870_ChIP-Seq_TREG_Human	1.99798794
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.91002050
19	FUS_26573619_Chip-Seq_HEK293_Human	1.90281352
20	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.89298926
21	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.83772224
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.70192705
23	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.68475142
24	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.67629234
25	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.66082928
26	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.66082928
27	GBX2_23144817_ChIP-Seq_PC3_Human	1.63491206
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59741567
29	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.58235237
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.57002323
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.54233528
32	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.52899504
33	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.52258798
34	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.50437996
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50367268
36	AR_20517297_ChIP-Seq_VCAP_Human	1.48332226
37	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.47904694
38	ER_23166858_ChIP-Seq_MCF-7_Human	1.45421149
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.45014845
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.45014845
41	HOXB7_26014856_ChIP-Seq_BT474_Human	1.44807981
42	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.44413645
43	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.44382101
44	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42236749
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.40316260
46	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40316260
47	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.40059022
48	ELK1_19687146_ChIP-ChIP_HELA_Human	1.38929634
49	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.38796145
50	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.38692357
51	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.38638035
52	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.37284205
53	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.36817139
54	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.36382359
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35302492
56	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.34153092
57	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.33026882
58	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.32961633
59	P300_19829295_ChIP-Seq_ESCs_Human	1.31892520
60	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.31487713
61	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.30198668
62	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.30058513
63	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.27629467
64	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.23569970
65	DCP1A_22483619_ChIP-Seq_HELA_Human	1.21255336
66	TTF2_22483619_ChIP-Seq_HELA_Human	1.20669990
67	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19247068
68	TCF4_23295773_ChIP-Seq_U87_Human	1.17823279
69	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17158785
70	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.16634473
71	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.15182439
72	CDX2_22108803_ChIP-Seq_LS180_Human	1.14695545
73	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.12782090
74	RBPJ_21746931_ChIP-Seq_IB4_Human	1.11593690
75	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.10201169
76	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.08973843
77	BCAT_22108803_ChIP-Seq_LS180_Human	1.06743463
78	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05454516
79	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.03821929
80	NCOR_22424771_ChIP-Seq_293T_Human	1.03009833
81	ETV1_20927104_ChIP-Seq_GIST48_Human	1.00786111
82	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.00690801
83	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.99257441
84	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.99034524
85	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.98871487
86	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.98263342
87	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.97816809
88	IGF1R_20145208_ChIP-Seq_DFB_Human	0.97604957
89	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.96933518
90	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.95234946
91	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94687412
92	SOX2_19829295_ChIP-Seq_ESCs_Human	0.94687412
93	P53_21459846_ChIP-Seq_SAOS-2_Human	0.93641092
94	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.93629835
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.92437362
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.92330343
97	HTT_18923047_ChIP-ChIP_STHdh_Human	0.92324227
98	NANOG_20526341_ChIP-Seq_ESCs_Human	0.91341235
99	GATA3_26560356_Chip-Seq_TH2_Human	0.90239428
100	TFEB_21752829_ChIP-Seq_HELA_Human	0.88768174

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005646_abnormal_pituitary_gland	3.70134338
2	MP0005310_abnormal_salivary_gland	3.63288145
3	MP0006072_abnormal_retinal_apoptosis	3.49872154
4	MP0005085_abnormal_gallbladder_physiolo	3.45492685
5	MP0003011_delayed_dark_adaptation	3.36708055
6	MP0004484_altered_response_of	2.93959146
7	MP0009764_decreased_sensitivity_to	2.74220426
8	MP0003136_yellow_coat_color	2.67349699
9	MP0004147_increased_porphyrin_level	2.67205372
10	MP0003718_maternal_effect	2.35187007
11	MP0005551_abnormal_eye_electrophysiolog	2.33826266
12	MP0003195_calcinosis	2.23367321
13	MP0005253_abnormal_eye_physiology	2.18225847
14	MP0002876_abnormal_thyroid_physiology	2.15723998
15	MP0008877_abnormal_DNA_methylation	2.09130364
16	MP0008872_abnormal_physiological_respon	2.02919340
17	MP0009379_abnormal_foot_pigmentation	1.92181099
18	MP0009780_abnormal_chondrocyte_physiolo	1.91730240
19	MP0008058_abnormal_DNA_repair	1.91280650
20	MP0005167_abnormal_blood-brain_barrier	1.89245230
21	MP0005365_abnormal_bile_salt	1.89076729
22	MP0001764_abnormal_homeostasis	1.88561051
23	MP0008875_abnormal_xenobiotic_pharmacok	1.87499226
24	MP0003646_muscle_fatigue	1.86964519
25	MP0004885_abnormal_endolymph	1.81526728
26	MP0000372_irregular_coat_pigmentation	1.65033193
27	MP0004742_abnormal_vestibular_system	1.64909808
28	MP0002928_abnormal_bile_duct	1.61160129
29	MP0005410_abnormal_fertilization	1.59919781
30	MP0002638_abnormal_pupillary_reflex	1.53987295
31	MP0009697_abnormal_copulation	1.52631656
32	MP0000631_abnormal_neuroendocrine_gland	1.51603992
33	MP0009643_abnormal_urine_homeostasis	1.49885348
34	MP0005360_urolithiasis	1.48561931
35	MP0004043_abnormal_pH_regulation	1.47574774
36	MP0009745_abnormal_behavioral_response	1.47011019
37	MP0002138_abnormal_hepatobiliary_system	1.36790737
38	MP0004215_abnormal_myocardial_fiber	1.35347164
39	MP0005332_abnormal_amino_acid	1.31279962
40	MP0003638_abnormal_response/metabolism_	1.29850926
41	MP0002254_reproductive_system_inflammat	1.27621774
42	MP0002693_abnormal_pancreas_physiology	1.27172280
43	MP0004957_abnormal_blastocyst_morpholog	1.21507858
44	MP0010094_abnormal_chromosome_stability	1.18044043
45	MP0005084_abnormal_gallbladder_morpholo	1.13945717
46	MP0006292_abnormal_olfactory_placode	1.13917131
47	MP0003878_abnormal_ear_physiology	1.12913440
48	MP0005377_hearing/vestibular/ear_phenot	1.12913440
49	MP0004782_abnormal_surfactant_physiolog	1.11939297
50	MP0005165_increased_susceptibility_to	1.09314609
51	MP0002127_abnormal_cardiovascular_syste	1.06351272
52	MP0002210_abnormal_sex_determination	1.05523629
53	MP0005187_abnormal_penis_morphology	1.04281111
54	MP0001324_abnormal_eye_pigmentation	1.02281853
55	MP0001502_abnormal_circadian_rhythm	1.01478803
56	MP0001666_abnormal_nutrient_absorption	1.01377527
57	MP0005671_abnormal_response_to	0.99966341
58	MP0002938_white_spotting	0.99245783
59	MP0001905_abnormal_dopamine_level	0.99094268
60	MP0002102_abnormal_ear_morphology	0.98806229
61	MP0008775_abnormal_heart_ventricle	0.98453579
62	MP0004133_heterotaxia	0.96895290
63	MP0003787_abnormal_imprinting	0.96376058
64	MP0006036_abnormal_mitochondrial_physio	0.95378984
65	MP0000230_abnormal_systemic_arterial	0.92570159
66	MP0005195_abnormal_posterior_eye	0.91503861
67	MP0000383_abnormal_hair_follicle	0.90182165
68	MP0002090_abnormal_vision	0.87267061
69	MP0004084_abnormal_cardiac_muscle	0.86680850
70	MP0002277_abnormal_respiratory_mucosa	0.85817928
71	MP0001986_abnormal_taste_sensitivity	0.85453631
72	MP0001501_abnormal_sleep_pattern	0.85243230
73	MP0002733_abnormal_thermal_nociception	0.84320948
74	MP0005391_vision/eye_phenotype	0.83144773
75	MP0001929_abnormal_gametogenesis	0.82205903
76	MP0001293_anophthalmia	0.82004729
77	MP0001188_hyperpigmentation	0.81897160
78	MP0001970_abnormal_pain_threshold	0.79979812
79	MP0002136_abnormal_kidney_physiology	0.79820051
80	MP0001800_abnormal_humoral_immune	0.79702011
81	MP0003221_abnormal_cardiomyocyte_apopto	0.79544588
82	MP0006276_abnormal_autonomic_nervous	0.78944632
83	MP0003698_abnormal_male_reproductive	0.78120337
84	MP0010386_abnormal_urinary_bladder	0.77463004
85	MP0005645_abnormal_hypothalamus_physiol	0.75646173
86	MP0002723_abnormal_immune_serum	0.74313539
87	MP0005395_other_phenotype	0.73612260
88	MP0005075_abnormal_melanosome_morpholog	0.72454332
89	MP0000653_abnormal_sex_gland	0.71691117
90	MP0001119_abnormal_female_reproductive	0.70931107
91	MP0004085_abnormal_heartbeat	0.70327185
92	MP0001286_abnormal_eye_development	0.69196270
93	MP0002557_abnormal_social/conspecific_i	0.68829559
94	MP0008469_abnormal_protein_level	0.68721576
95	MP0000427_abnormal_hair_cycle	0.68578858
96	MP0005647_abnormal_sex_gland	0.68065483
97	MP0002272_abnormal_nervous_system	0.68013029
98	MP0002234_abnormal_pharynx_morphology	0.65456588
99	MP0001968_abnormal_touch/_nociception	0.64598444
100	MP0002095_abnormal_skin_pigmentation	0.63797201

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	5.19058609
2	Abnormal rod and cone electroretinograms (HP:0008323)	4.56376894
3	Abnormal biliary tract physiology (HP:0012439)	4.39782642
4	Bile duct proliferation (HP:0001408)	4.39782642
5	Pigmentary retinal degeneration (HP:0001146)	4.28350315
6	Chronic bronchitis (HP:0004469)	4.20194018
7	Pancreatic cysts (HP:0001737)	4.07277818
8	Choroideremia (HP:0001139)	4.03924572
9	Congenital stationary night blindness (HP:0007642)	3.95741477
10	True hermaphroditism (HP:0010459)	3.73661128
11	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.71796693
12	Decreased central vision (HP:0007663)	3.57150542
13	Pancreatic fibrosis (HP:0100732)	3.49463419
14	Lipid accumulation in hepatocytes (HP:0006561)	3.38273264
15	Decreased circulating renin level (HP:0003351)	3.37607782
16	Attenuation of retinal blood vessels (HP:0007843)	3.35388446
17	Molar tooth sign on MRI (HP:0002419)	3.09563190
18	Abnormality of midbrain morphology (HP:0002418)	3.09563190
19	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.00003003
20	Abnormality of alanine metabolism (HP:0010916)	3.00003003
21	Hyperalaninemia (HP:0003348)	3.00003003
22	Thyroid-stimulating hormone excess (HP:0002925)	2.99981719
23	Bony spicule pigmentary retinopathy (HP:0007737)	2.77745113
24	Abnormality of the pons (HP:0007361)	2.73041828
25	Increased hepatocellular lipid droplets (HP:0006565)	2.70270834
26	Hypoplasia of the pons (HP:0012110)	2.63887245
27	Rimmed vacuoles (HP:0003805)	2.57084875
28	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.51410850
29	Flat occiput (HP:0005469)	2.50537341
30	Abnormal respiratory motile cilium physiology (HP:0012261)	2.49055956
31	Central scotoma (HP:0000603)	2.49045359
32	Chronic hepatic failure (HP:0100626)	2.40640065
33	Biliary tract neoplasm (HP:0100574)	2.38332591
34	Constricted visual fields (HP:0001133)	2.35171871
35	Severe Myopia (HP:0011003)	2.33828426
36	Ependymoma (HP:0002888)	2.27549057
37	Mitochondrial inheritance (HP:0001427)	2.27235071
38	Cystic liver disease (HP:0006706)	2.26998881
39	Abnormality of the renal cortex (HP:0011035)	2.25179149
40	Bronchitis (HP:0012387)	2.22092210
41	Abnormal number of erythroid precursors (HP:0012131)	2.19084326
42	Type II lissencephaly (HP:0007260)	2.17690997
43	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.17283157
44	Increased serum lactate (HP:0002151)	2.17187835
45	Meckel diverticulum (HP:0002245)	2.16556624
46	Neutropenia (HP:0001875)	2.15532036
47	Rhinitis (HP:0012384)	2.14459966
48	Hyperkalemia (HP:0002153)	2.14445057
49	Polydipsia (HP:0001959)	2.12551967
50	Abnormal drinking behavior (HP:0030082)	2.12551967
51	Conical tooth (HP:0000698)	2.11265025
52	3-Methylglutaconic aciduria (HP:0003535)	2.10805395
53	Colon cancer (HP:0003003)	2.10550904
54	IgG deficiency (HP:0004315)	2.10485581
55	IgM deficiency (HP:0002850)	2.07996429
56	Increased CSF lactate (HP:0002490)	2.07603607
57	Hypokalemic alkalosis (HP:0001949)	2.05193804
58	Recurrent otitis media (HP:0000403)	2.05098838
59	Oral leukoplakia (HP:0002745)	2.03189200
60	Abnormality of the ileum (HP:0001549)	2.03029824
61	Furrowed tongue (HP:0000221)	2.02720885
62	Anencephaly (HP:0002323)	2.02109441
63	Congenital hepatic fibrosis (HP:0002612)	1.98853756
64	Nephronophthisis (HP:0000090)	1.98602773
65	Cerebellar dysplasia (HP:0007033)	1.97929832
66	Aplasia/hypoplasia of the uterus (HP:0008684)	1.97695721
67	Congenital, generalized hypertrichosis (HP:0004540)	1.97228324
68	Acute necrotizing encephalopathy (HP:0006965)	1.96417936
69	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.95701732
70	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.95701732
71	Confusion (HP:0001289)	1.95051981
72	Sclerocornea (HP:0000647)	1.94932224
73	Aplastic anemia (HP:0001915)	1.91348861
74	Respiratory difficulties (HP:0002880)	1.90853072
75	Hepatocellular necrosis (HP:0001404)	1.90744270
76	Supernumerary spleens (HP:0009799)	1.89849137
77	Male pseudohermaphroditism (HP:0000037)	1.85296832
78	Abnormality of the preputium (HP:0100587)	1.84921272
79	Hepatic necrosis (HP:0002605)	1.84868867
80	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.83781419
81	Renal Fanconi syndrome (HP:0001994)	1.81541055
82	Abnormality of renin-angiotensin system (HP:0000847)	1.81204876
83	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.80723251
84	Renal cortical cysts (HP:0000803)	1.80436595
85	Hyperactive renin-angiotensin system (HP:0000841)	1.77924531
86	Abnormality of cells of the erythroid lineage (HP:0012130)	1.77574580
87	Retinitis pigmentosa (HP:0000510)	1.77446812
88	Increased cerebral lipofuscin (HP:0011813)	1.77121159
89	Abolished electroretinogram (ERG) (HP:0000550)	1.76825692
90	Occipital encephalocele (HP:0002085)	1.76053343
91	Glioma (HP:0009733)	1.74130855
92	Polyuria (HP:0000103)	1.73134896
93	Clubbing of toes (HP:0100760)	1.72900229
94	Pendular nystagmus (HP:0012043)	1.72263711
95	Hypoalbuminemia (HP:0003073)	1.71805606
96	Abnormal albumin level (HP:0012116)	1.71805606
97	Lactic acidosis (HP:0003128)	1.71713691
98	Increased muscle lipid content (HP:0009058)	1.71065940
99	Opisthotonus (HP:0002179)	1.71015594
100	Hyperaldosteronism (HP:0000859)	1.70934982

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BLK	7.90254516
2	MAP3K9	4.95924996
3	ZAK	3.43153733
4	FRK	3.35341995
5	CAMKK2	3.27318493
6	CAMK1D	2.69451570
7	PINK1	2.16754524
8	VRK2	2.12603526
9	NUAK1	2.02464854
10	MAPKAPK5	1.92614773
11	SRPK1	1.87591093
12	GRK1	1.85686118
13	DYRK3	1.78696016
14	TLK1	1.74407913
15	VRK1	1.65995586
16	WNK3	1.62496191
17	MST4	1.61843718
18	CAMK1G	1.58250051
19	TAOK3	1.51013360
20	MKNK1	1.49496275
21	ADRBK2	1.45274430
22	TAF1	1.41502739
23	RPS6KA4	1.35390695
24	PDK1	1.31931616
25	TNK2	1.31666027
26	DYRK2	1.24999627
27	PDPK1	1.23045529
28	WNK4	1.20996017
29	TSSK6	1.17687939
30	TXK	1.14394938
31	CDC7	1.12211168
32	BUB1	1.10461358
33	CAMK4	1.03974577
34	MKNK2	1.00167717
35	MAPKAPK3	0.98328851
36	OXSR1	0.96029795
37	PLK3	0.93551709
38	NEK1	0.91514244
39	MAP4K2	0.86038157
40	STK38L	0.85273529
41	HIPK2	0.85113886
42	EPHA4	0.84252378
43	DAPK2	0.83197302
44	MELK	0.81043685
45	ITK	0.80261415
46	CAMKK1	0.79415932
47	MUSK	0.77134302
48	RPS6KA5	0.76176125
49	STK16	0.74196094
50	TESK2	0.73987029
51	KIT	0.73673350
52	MARK3	0.72069361
53	IKBKB	0.69839053
54	STK39	0.67668678
55	ATR	0.64405104
56	FLT3	0.64327463
57	PASK	0.62204215
58	BMPR1B	0.60415084
59	ALK	0.59250981
60	PLK4	0.56862827
61	CSNK1E	0.55568731
62	PRKCQ	0.53436541
63	ACVR1B	0.51260467
64	WEE1	0.51151365
65	PLK1	0.50781054
66	ADRBK1	0.50627252
67	PBK	0.50602872
68	AURKB	0.49433858
69	LYN	0.46628920
70	CDK19	0.46538156
71	NLK	0.45710793
72	EIF2AK3	0.44884286
73	PRKCE	0.44734447
74	CSNK2A2	0.44080378
75	MAPK15	0.42981672
76	CDK9	0.42448963
77	INSRR	0.42429971
78	TIE1	0.41934820
79	TTK	0.39132529
80	TEC	0.39043887
81	GSK3A	0.38357259
82	ERBB2	0.36570341
83	CDK8	0.32632522
84	MAP3K4	0.31780256
85	CAMK1	0.31338910
86	MAP2K6	0.29924211
87	TRIM28	0.29556484
88	RPS6KA6	0.27576429
89	TGFBR1	0.26063235
90	MAP3K5	0.25158624
91	TNIK	0.24612400
92	PRKCG	0.24567072
93	BRSK2	0.23857274
94	PRKG1	0.23612316
95	PIM1	0.23579779
96	CHEK2	0.23172984
97	PRKG2	0.23147647
98	NEK2	0.21919439
99	PRKCI	0.21866753
100	TRPM7	0.21392426

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Regulation of autophagy_Homo sapiens_hsa04140	3.69600452
2	Propanoate metabolism_Homo sapiens_hsa00640	3.29840456
3	Linoleic acid metabolism_Homo sapiens_hsa00591	3.12389962
4	One carbon pool by folate_Homo sapiens_hsa00670	3.09128569
5	Caffeine metabolism_Homo sapiens_hsa00232	2.90041234
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.81407504
7	Proteasome_Homo sapiens_hsa03050	2.71249440
8	Ribosome_Homo sapiens_hsa03010	2.32028256
9	Mismatch repair_Homo sapiens_hsa03430	2.29593110
10	Pyruvate metabolism_Homo sapiens_hsa00620	2.07990478
11	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.06687737
12	Oxidative phosphorylation_Homo sapiens_hsa00190	2.05564712
13	RNA polymerase_Homo sapiens_hsa03020	1.96529471
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.94648289
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.88126782
16	Phototransduction_Homo sapiens_hsa04744	1.86187755
17	Basal transcription factors_Homo sapiens_hsa03022	1.83198549
18	Sulfur metabolism_Homo sapiens_hsa00920	1.79164439
19	RNA degradation_Homo sapiens_hsa03018	1.73147473
20	Homologous recombination_Homo sapiens_hsa03440	1.71817076
21	Protein export_Homo sapiens_hsa03060	1.69715095
22	Fatty acid degradation_Homo sapiens_hsa00071	1.68871679
23	Parkinsons disease_Homo sapiens_hsa05012	1.66654864
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.52064039
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.43825051
26	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.36812394
27	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.36274485
28	Asthma_Homo sapiens_hsa05310	1.33722996
29	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.32541352
30	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.17855548
31	Huntingtons disease_Homo sapiens_hsa05016	1.17046483
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.16836593
33	Primary immunodeficiency_Homo sapiens_hsa05340	1.16592935
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.15754095
35	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.11232581
36	Fatty acid metabolism_Homo sapiens_hsa01212	1.08701486
37	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.07385315
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.06520017
39	Allograft rejection_Homo sapiens_hsa05330	1.00022502
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.99792048
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.96863078
42	Alzheimers disease_Homo sapiens_hsa05010	0.93776258
43	Purine metabolism_Homo sapiens_hsa00230	0.93577565
44	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.93365703
45	Spliceosome_Homo sapiens_hsa03040	0.92425021
46	Cardiac muscle contraction_Homo sapiens_hsa04260	0.86781740
47	RNA transport_Homo sapiens_hsa03013	0.86047857
48	Sulfur relay system_Homo sapiens_hsa04122	0.85451997
49	Fat digestion and absorption_Homo sapiens_hsa04975	0.85422011
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.83974600
51	Butanoate metabolism_Homo sapiens_hsa00650	0.83849309
52	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.83110011
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.82959620
54	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.81825889
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.80545302
56	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.80348091
57	Retinol metabolism_Homo sapiens_hsa00830	0.79216741
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.79178682
59	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.77999275
60	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.74631624
61	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.73753291
62	Steroid biosynthesis_Homo sapiens_hsa00100	0.73307058
63	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.71617155
64	DNA replication_Homo sapiens_hsa03030	0.71280188
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.69340736
66	Base excision repair_Homo sapiens_hsa03410	0.65162616
67	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.65066182
68	Morphine addiction_Homo sapiens_hsa05032	0.64892490
69	Metabolic pathways_Homo sapiens_hsa01100	0.62661330
70	PPAR signaling pathway_Homo sapiens_hsa03320	0.60125581
71	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59219309
72	Arginine and proline metabolism_Homo sapiens_hsa00330	0.58788826
73	Non-homologous end-joining_Homo sapiens_hsa03450	0.58737762
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58096704
75	Lysine degradation_Homo sapiens_hsa00310	0.56478010
76	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.56244496
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.52941611
78	Serotonergic synapse_Homo sapiens_hsa04726	0.51978325
79	Taste transduction_Homo sapiens_hsa04742	0.50998029
80	Cell cycle_Homo sapiens_hsa04110	0.48872937
81	Arginine biosynthesis_Homo sapiens_hsa00220	0.48288360
82	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47914383
83	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.45517106
84	Olfactory transduction_Homo sapiens_hsa04740	0.43519414
85	Glutathione metabolism_Homo sapiens_hsa00480	0.42773592
86	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.42078591
87	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.39764209
88	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.39561991
89	Nucleotide excision repair_Homo sapiens_hsa03420	0.39313957
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.38187024
91	FoxO signaling pathway_Homo sapiens_hsa04068	0.36981674
92	Nicotine addiction_Homo sapiens_hsa05033	0.35420617
93	Graft-versus-host disease_Homo sapiens_hsa05332	0.34977315
94	Glucagon signaling pathway_Homo sapiens_hsa04922	0.33843231
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.32159035
96	Type I diabetes mellitus_Homo sapiens_hsa04940	0.31620993
97	Antigen processing and presentation_Homo sapiens_hsa04612	0.29612084
98	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.29367009
99	Mineral absorption_Homo sapiens_hsa04978	0.28961737
100	Peroxisome_Homo sapiens_hsa04146	0.28794782

HNRNPA1P36

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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