ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.11815414
2	DNA deamination (GO:0045006)	4.80059124
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.60186805
4	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.51048138
5	termination of RNA polymerase III transcription (GO:0006386)	4.41592597
6	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.41592597
7	pseudouridine synthesis (GO:0001522)	4.34986770
8	ATP synthesis coupled proton transport (GO:0015986)	4.20644218
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.20644218
10	response to pheromone (GO:0019236)	4.14444458
11	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.13707891
12	NADH dehydrogenase complex assembly (GO:0010257)	3.95110189
13	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.95110189
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.95110189
15	rRNA modification (GO:0000154)	3.94152945
16	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	3.83975022
17	protein complex biogenesis (GO:0070271)	3.83916362
18	regulation of mitotic spindle checkpoint (GO:1903504)	3.79314859
19	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.79314859
20	chaperone-mediated protein transport (GO:0072321)	3.74796804
21	cytidine metabolic process (GO:0046087)	3.74718162
22	cytidine catabolic process (GO:0006216)	3.74718162
23	cytidine deamination (GO:0009972)	3.74718162
24	proteasome assembly (GO:0043248)	3.69326142
25	regulation of mitochondrial translation (GO:0070129)	3.63863309
26	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.59156132
27	respiratory electron transport chain (GO:0022904)	3.58619371
28	mitochondrial respiratory chain complex assembly (GO:0033108)	3.58420568
29	folic acid-containing compound biosynthetic process (GO:0009396)	3.57784558
30	base-excision repair, AP site formation (GO:0006285)	3.56196986
31	electron transport chain (GO:0022900)	3.53105170
32	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.41533498
33	glucosamine-containing compound catabolic process (GO:1901072)	3.36370958
34	respiratory chain complex IV assembly (GO:0008535)	3.35139810
35	negative regulation by host of viral transcription (GO:0043922)	3.29721615
36	rRNA methylation (GO:0031167)	3.28917987
37	DNA catabolic process, exonucleolytic (GO:0000738)	3.24315093
38	rRNA processing (GO:0006364)	3.19686488
39	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.18853456
40	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.18853456
41	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.17248468
42	IMP biosynthetic process (GO:0006188)	3.16923607
43	DNA double-strand break processing (GO:0000729)	3.14634172
44	rhodopsin mediated signaling pathway (GO:0016056)	3.12323149
45	protein neddylation (GO:0045116)	3.10420867
46	pteridine-containing compound biosynthetic process (GO:0042559)	3.09706705
47	viral mRNA export from host cell nucleus (GO:0046784)	3.08829567
48	water-soluble vitamin biosynthetic process (GO:0042364)	3.08605574
49	rRNA metabolic process (GO:0016072)	3.06313465
50	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.01801211
51	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.01744579
52	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.97401585
53	multicellular organism reproduction (GO:0032504)	2.96300611
54	cytochrome complex assembly (GO:0017004)	2.95605294
55	inner mitochondrial membrane organization (GO:0007007)	2.89175911
56	lymphocyte chemotaxis (GO:0048247)	2.88690688
57	maturation of SSU-rRNA (GO:0030490)	2.87005347
58	translation (GO:0006412)	2.86783151
59	mast cell activation (GO:0045576)	2.85368815
60	platelet dense granule organization (GO:0060155)	2.84454703
61	ribosome biogenesis (GO:0042254)	2.84222555
62	regulation of cellular amino acid metabolic process (GO:0006521)	2.82586957
63	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.78403997
64	cellular component biogenesis (GO:0044085)	2.77716848
65	RNA phosphodiester bond hydrolysis (GO:0090501)	2.75713030
66	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.74855170
67	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.72424309
68	translational termination (GO:0006415)	2.72078852
69	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.71997119
70	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.71162049
71	translational elongation (GO:0006414)	2.66536902
72	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.66518802
73	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.66417850
74	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.65409440
75	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.65256371
76	pyrimidine nucleotide catabolic process (GO:0006244)	2.64201849
77	viral transcription (GO:0019083)	2.63727413
78	intracellular protein transmembrane import (GO:0044743)	2.63349198
79	positive regulation of humoral immune response (GO:0002922)	2.62900128
80	DNA damage response, detection of DNA damage (GO:0042769)	2.62453225
81	negative regulation of ligase activity (GO:0051352)	2.60907599
82	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.60907599
83	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.60539883
84	regulation of regulatory T cell differentiation (GO:0045589)	2.60414802
85	IMP metabolic process (GO:0046040)	2.58500218
86	tRNA processing (GO:0008033)	2.56892314
87	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.55571681
88	isotype switching (GO:0045190)	2.55571681
89	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.55571681
90	deoxyribose phosphate catabolic process (GO:0046386)	2.50078082
91	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.49113888
92	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.49113888
93	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.49113888
94	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.48871154
95	tRNA metabolic process (GO:0006399)	2.48382912
96	dopamine transport (GO:0015872)	2.47401508
97	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.46690922
98	ATP biosynthetic process (GO:0006754)	2.46327913
99	B cell mediated immunity (GO:0019724)	2.45162184
100	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.44502988

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.18184242
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.07154342
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.93565912
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.79945253
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.75539871
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.59933779
7	E2F7_22180533_ChIP-Seq_HELA_Human	3.29653047
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.09796694
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.82577141
10	VDR_22108803_ChIP-Seq_LS180_Human	2.77218435
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.73298748
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.64650774
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.64521388
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.62816067
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.31867421
16	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.29971425
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.25645131
18	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.23857363
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.23838783
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.22817309
21	ZNF274_21170338_ChIP-Seq_K562_Hela	2.06191044
22	MYC_18940864_ChIP-ChIP_HL60_Human	2.03490932
23	ELK1_19687146_ChIP-ChIP_HELA_Human	2.01310137
24	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.97949803
25	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.91005071
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.83879788
27	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.74661586
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.66453478
29	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.60269944
30	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.58146492
31	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.57091728
32	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.56835669
33	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.56379107
34	EWS_26573619_Chip-Seq_HEK293_Human	1.55983689
35	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.51045699
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48623428
37	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.46437461
38	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.45174141
39	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.41489116
40	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.39062891
41	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.37708898
42	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.37578444
43	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.35539939
44	FUS_26573619_Chip-Seq_HEK293_Human	1.34917951
45	EZH2_22144423_ChIP-Seq_EOC_Human	1.34870114
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28740571
47	GABP_19822575_ChIP-Seq_HepG2_Human	1.28255544
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28122028
49	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.27758319
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27624140
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27624140
52	DCP1A_22483619_ChIP-Seq_HELA_Human	1.26668651
53	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.24810462
54	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.23002566
55	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.21713512
56	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.21507582
57	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.21458516
58	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.19875899
59	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.17993693
60	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.16635644
61	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.15216489
62	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.14879592
63	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.14227713
64	TAF15_26573619_Chip-Seq_HEK293_Human	1.13093449
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.12775791
66	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12582064
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11696645
68	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.10905373
69	TTF2_22483619_ChIP-Seq_HELA_Human	1.10660638
70	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.10581605
71	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.10271958
72	CIITA_25753668_ChIP-Seq_RAJI_Human	1.09988326
73	ER_23166858_ChIP-Seq_MCF-7_Human	1.09854228
74	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.08844400
75	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07330540
76	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.06835333
77	AR_20517297_ChIP-Seq_VCAP_Human	1.05463235
78	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.04261266
79	NANOG_20526341_ChIP-Seq_ESCs_Human	1.03070362
80	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.02931135
81	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.01830741
82	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.01505320
83	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.01219714
84	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.99220876
85	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.99102290
86	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.98410345
87	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.97843229
88	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97660752
89	XRN2_22483619_ChIP-Seq_HELA_Human	0.96956716
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96268879
91	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.95442309
92	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.95226901
93	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.93799724
94	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.92955049
95	GATA3_26560356_Chip-Seq_TH2_Human	0.91789864
96	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.90686851
97	P300_19829295_ChIP-Seq_ESCs_Human	0.90362743
98	NCOR_22424771_ChIP-Seq_293T_Human	0.89968416
99	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.89677487
100	CBP_20019798_ChIP-Seq_JUKART_Human	0.89677487

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.16767107
2	MP0006072_abnormal_retinal_apoptosis	3.50527527
3	MP0002638_abnormal_pupillary_reflex	2.64837149
4	MP0000566_synostosis	2.57638284
5	MP0003806_abnormal_nucleotide_metabolis	2.27106378
6	MP0003646_muscle_fatigue	2.26789623
7	MP0000569_abnormal_digit_pigmentation	2.16137686
8	MP0001835_abnormal_antigen_presentation	2.15582801
9	MP0005085_abnormal_gallbladder_physiolo	2.09748115
10	MP0005253_abnormal_eye_physiology	2.06815792
11	MP0000685_abnormal_immune_system	2.04625464
12	MP0008872_abnormal_physiological_respon	2.01285086
13	MP0003786_premature_aging	1.95395488
14	MP0010094_abnormal_chromosome_stability	1.93426361
15	MP0002006_tumorigenesis	1.85911860
16	MP0009785_altered_susceptibility_to	1.84582131
17	MP0001764_abnormal_homeostasis	1.83725204
18	MP0009333_abnormal_splenocyte_physiolog	1.76032898
19	MP0002736_abnormal_nociception_after	1.74883056
20	MP0009379_abnormal_foot_pigmentation	1.71862416
21	MP0005387_immune_system_phenotype	1.69067483
22	MP0001790_abnormal_immune_system	1.69067483
23	MP0005551_abnormal_eye_electrophysiolog	1.67101877
24	MP0008875_abnormal_xenobiotic_pharmacok	1.64105355
25	MP0003567_abnormal_fetal_cardiomyocyte	1.62079513
26	MP0008877_abnormal_DNA_methylation	1.60561018
27	MP0003763_abnormal_thymus_physiology	1.58943872
28	MP0005645_abnormal_hypothalamus_physiol	1.57432475
29	MP0002163_abnormal_gland_morphology	1.55855742
30	MP0006292_abnormal_olfactory_placode	1.54307209
31	MP0002102_abnormal_ear_morphology	1.54094947
32	MP0008995_early_reproductive_senescence	1.51266346
33	MP0003693_abnormal_embryo_hatching	1.51019625
34	MP0004957_abnormal_blastocyst_morpholog	1.50666576
35	MP0001800_abnormal_humoral_immune	1.47705422
36	MP0005084_abnormal_gallbladder_morpholo	1.46411894
37	MP0006036_abnormal_mitochondrial_physio	1.45145870
38	MP0008058_abnormal_DNA_repair	1.42669511
39	MP0002876_abnormal_thyroid_physiology	1.40432770
40	MP0001968_abnormal_touch/_nociception	1.39604123
41	MP0002166_altered_tumor_susceptibility	1.39030824
42	MP0001919_abnormal_reproductive_system	1.36081446
43	MP0003252_abnormal_bile_duct	1.34978332
44	MP0002148_abnormal_hypersensitivity_rea	1.34923977
45	MP0005365_abnormal_bile_salt	1.32742566
46	MP0008057_abnormal_DNA_replication	1.32025584
47	MP0010155_abnormal_intestine_physiology	1.27799105
48	MP0004043_abnormal_pH_regulation	1.24840995
49	MP0009764_decreased_sensitivity_to	1.19250699
50	MP0000490_abnormal_crypts_of	1.18655065
51	MP0002095_abnormal_skin_pigmentation	1.15407452
52	MP0005000_abnormal_immune_tolerance	1.13042125
53	MP0001873_stomach_inflammation	1.12988791
54	MP0002723_abnormal_immune_serum	1.11076962
55	MP0009745_abnormal_behavioral_response	1.09480775
56	MP0005167_abnormal_blood-brain_barrier	1.08797975
57	MP0005025_abnormal_response_to	1.08594677
58	MP0005360_urolithiasis	1.05608430
59	MP0002452_abnormal_antigen_presenting	1.05251836
60	MP0002420_abnormal_adaptive_immunity	1.04874235
61	MP0001819_abnormal_immune_cell	1.04718356
62	MP0002139_abnormal_hepatobiliary_system	1.03908924
63	MP0005389_reproductive_system_phenotype	1.02639306
64	MP0003890_abnormal_embryonic-extraembry	1.01819478
65	MP0002210_abnormal_sex_determination	1.01534055
66	MP0001119_abnormal_female_reproductive	0.99675450
67	MP0003111_abnormal_nucleus_morphology	0.98380594
68	MP0003718_maternal_effect	0.97931770
69	MP0001293_anophthalmia	0.97111506
70	MP0004142_abnormal_muscle_tone	0.96943259
71	MP0003195_calcinosis	0.96724698
72	MP0000703_abnormal_thymus_morphology	0.96097501
73	MP0010329_abnormal_lipoprotein_level	0.92064033
74	MP0002272_abnormal_nervous_system	0.89416296
75	MP0001905_abnormal_dopamine_level	0.89257540
76	MP0000716_abnormal_immune_system	0.88991193
77	MP0002398_abnormal_bone_marrow	0.88797712
78	MP0005391_vision/eye_phenotype	0.88014011
79	MP0003866_abnormal_defecation	0.87497039
80	MP0005379_endocrine/exocrine_gland_phen	0.87200361
81	MP0000689_abnormal_spleen_morphology	0.86493400
82	MP0001666_abnormal_nutrient_absorption	0.83968476
83	MP0005410_abnormal_fertilization	0.83621556
84	MP0001501_abnormal_sleep_pattern	0.80031706
85	MP0000653_abnormal_sex_gland	0.77302618
86	MP0002822_catalepsy	0.77182523
87	MP0002138_abnormal_hepatobiliary_system	0.76981823
88	MP0001929_abnormal_gametogenesis	0.76955046
89	MP0009046_muscle_twitch	0.76340419
90	MP0001986_abnormal_taste_sensitivity	0.76292825
91	MP0006082_CNS_inflammation	0.75738568
92	MP0001485_abnormal_pinna_reflex	0.75433368
93	MP0002722_abnormal_immune_system	0.75184996
94	MP0002233_abnormal_nose_morphology	0.74615547
95	MP0001529_abnormal_vocalization	0.74586170
96	MP0002429_abnormal_blood_cell	0.74452925
97	MP0003950_abnormal_plasma_membrane	0.73909757
98	MP0005195_abnormal_posterior_eye	0.73031727
99	MP0005310_abnormal_salivary_gland	0.72998984
100	MP0001145_abnormal_male_reproductive	0.72922636

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.96204125
2	Congenital stationary night blindness (HP:0007642)	4.49326414
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.39310638
4	Acute encephalopathy (HP:0006846)	4.33391789
5	Mitochondrial inheritance (HP:0001427)	4.31700451
6	Progressive macrocephaly (HP:0004481)	4.23608664
7	Increased CSF lactate (HP:0002490)	4.13903176
8	Hepatocellular necrosis (HP:0001404)	4.00560793
9	Hepatic necrosis (HP:0002605)	3.68945912
10	IgG deficiency (HP:0004315)	3.60383914
11	Aplastic anemia (HP:0001915)	3.18292246
12	Cerebral edema (HP:0002181)	3.09507325
13	Increased hepatocellular lipid droplets (HP:0006565)	3.04586244
14	Cerebral hypomyelination (HP:0006808)	2.94507765
15	Hypothermia (HP:0002045)	2.93901479
16	Lipid accumulation in hepatocytes (HP:0006561)	2.90327828
17	Hyperglycinemia (HP:0002154)	2.87445551
18	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.85704003
19	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.85704003
20	Abnormality of T cell number (HP:0011839)	2.71900070
21	Agammaglobulinemia (HP:0004432)	2.69468437
22	Increased serum lactate (HP:0002151)	2.63035363
23	Recurrent bronchitis (HP:0002837)	2.60100161
24	T lymphocytopenia (HP:0005403)	2.56419746
25	Increased intramyocellular lipid droplets (HP:0012240)	2.52340971
26	Type II lissencephaly (HP:0007260)	2.51706811
27	Generalized aminoaciduria (HP:0002909)	2.51454092
28	Chronic sinusitis (HP:0011109)	2.48849402
29	Optic disc pallor (HP:0000543)	2.47485836
30	Cerebellar dysplasia (HP:0007033)	2.42173185
31	Abnormality of macular pigmentation (HP:0008002)	2.40689570
32	Prostate neoplasm (HP:0100787)	2.39539745
33	Lactic acidosis (HP:0003128)	2.38836651
34	Severe combined immunodeficiency (HP:0004430)	2.38690570
35	Abnormality of T cells (HP:0002843)	2.37854924
36	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.37647187
37	Congenital, generalized hypertrichosis (HP:0004540)	2.34258770
38	Abnormal number of erythroid precursors (HP:0012131)	2.34017055
39	Methylmalonic acidemia (HP:0002912)	2.33343939
40	Reticulocytopenia (HP:0001896)	2.32046429
41	Respiratory failure (HP:0002878)	2.31494526
42	Abnormality of the labia minora (HP:0012880)	2.27923990
43	CNS hypomyelination (HP:0003429)	2.26299867
44	Renal cortical cysts (HP:0000803)	2.23815186
45	Delayed CNS myelination (HP:0002188)	2.23540221
46	Renal Fanconi syndrome (HP:0001994)	2.23258801
47	Thyroiditis (HP:0100646)	2.23195315
48	Parakeratosis (HP:0001036)	2.22675335
49	Abnormality of the ileum (HP:0001549)	2.21740719
50	B lymphocytopenia (HP:0010976)	2.20189412
51	Leukodystrophy (HP:0002415)	2.19475572
52	Pancreatic cysts (HP:0001737)	2.18295246
53	Meckel diverticulum (HP:0002245)	2.17068755
54	Abolished electroretinogram (ERG) (HP:0000550)	2.12919764
55	Increased muscle lipid content (HP:0009058)	2.10319631
56	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.07030896
57	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.05415962
58	Abnormal protein N-linked glycosylation (HP:0012347)	2.05415962
59	Abnormal protein glycosylation (HP:0012346)	2.05415962
60	Abnormal glycosylation (HP:0012345)	2.05415962
61	Abnormality of B cell number (HP:0010975)	2.05005037
62	Lethargy (HP:0001254)	2.04082761
63	Abnormality of eosinophils (HP:0001879)	2.03821300
64	Increased IgM level (HP:0003496)	2.01266299
65	Aplasia/hypoplasia of the uterus (HP:0008684)	2.00006619
66	Combined immunodeficiency (HP:0005387)	1.99541682
67	Methylmalonic aciduria (HP:0012120)	1.99357696
68	Type I transferrin isoform profile (HP:0003642)	1.98786649
69	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.98761256
70	Oral leukoplakia (HP:0002745)	1.98710762
71	Cellular immunodeficiency (HP:0005374)	1.98251097
72	Abnormality of cells of the erythroid lineage (HP:0012130)	1.96470012
73	Exercise intolerance (HP:0003546)	1.96178377
74	Multiple enchondromatosis (HP:0005701)	1.95565666
75	True hermaphroditism (HP:0010459)	1.95062604
76	Pancytopenia (HP:0001876)	1.92427551
77	Glycosuria (HP:0003076)	1.91745258
78	Abnormality of urine glucose concentration (HP:0011016)	1.91745258
79	IgM deficiency (HP:0002850)	1.91023671
80	Abnormality of the prostate (HP:0008775)	1.90003240
81	Hypoplasia of the pons (HP:0012110)	1.89998151
82	CNS demyelination (HP:0007305)	1.89475425
83	Abnormality of chromosome stability (HP:0003220)	1.87907138
84	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.87575292
85	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.86416514
86	Inability to walk (HP:0002540)	1.81298226
87	Premature ovarian failure (HP:0008209)	1.80515092
88	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.78532946
89	Abnormality of serum amino acid levels (HP:0003112)	1.78437218
90	Humeroradial synostosis (HP:0003041)	1.77827161
91	Synostosis involving the elbow (HP:0003938)	1.77827161
92	Abnormality of the pons (HP:0007361)	1.77040333
93	Azoospermia (HP:0000027)	1.76113971
94	Chromsome breakage (HP:0040012)	1.74160874
95	Abnormal spermatogenesis (HP:0008669)	1.73193536
96	Progressive microcephaly (HP:0000253)	1.70402653
97	Respiratory difficulties (HP:0002880)	1.69111230
98	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.68660342
99	Cleft eyelid (HP:0000625)	1.67716766
100	Bronchitis (HP:0012387)	1.67260804

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	5.05006025
2	MAP4K2	4.34385164
3	ZAK	3.63562881
4	STK16	3.23791448
5	BUB1	3.14443248
6	SIK2	3.03002882
7	TXK	2.99794619
8	GRK1	2.82057164
9	SIK3	2.34253583
10	TLK1	2.11003304
11	NEK1	1.99308431
12	TSSK6	1.97239699
13	MAPKAPK3	1.70729600
14	MST4	1.67302984
15	OXSR1	1.60726122
16	PINK1	1.55340907
17	CDK19	1.53075556
18	CDC7	1.49388919
19	SRPK1	1.46991207
20	TAOK3	1.43398939
21	WNK4	1.38608222
22	DAPK1	1.38181335
23	TNK2	1.37691614
24	TESK1	1.35943947
25	MAP3K12	1.33177261
26	PBK	1.33136503
27	WNK3	1.20874842
28	VRK1	1.19216307
29	ADRBK2	1.17420789
30	STK39	1.14602118
31	KDR	1.12765254
32	MST1R	1.07367788
33	GRK6	1.02416060
34	PLK4	1.00885633
35	MAP2K7	1.00883979
36	MAP4K1	1.00714847
37	SIK1	1.00040875
38	ITK	0.99641882
39	PASK	0.99059743
40	BCKDK	0.95742709
41	PLK3	0.95603345
42	CAMKK2	0.94486179
43	TNIK	0.92700855
44	FRK	0.90899117
45	VRK2	0.89907087
46	EIF2AK3	0.87569038
47	CCNB1	0.85159382
48	MARK3	0.84847528
49	BRSK2	0.84430945
50	AURKB	0.78518814
51	PIK3CG	0.78399487
52	JAK3	0.75173996
53	RPS6KA5	0.74654819
54	ATR	0.72447613
55	PLK1	0.66441230
56	NUAK1	0.66369658
57	DYRK2	0.66132423
58	LYN	0.64474329
59	PRKCQ	0.62686273
60	AURKA	0.61801231
61	TEC	0.59812607
62	PRKCG	0.57955470
63	STK38	0.57732990
64	INSRR	0.56862611
65	SYK	0.56527085
66	MKNK1	0.56385016
67	MAPK13	0.54078175
68	MKNK2	0.53194141
69	CHEK2	0.52572863
70	MYLK	0.48544078
71	IKBKE	0.47170889
72	CSNK2A2	0.46660935
73	BCR	0.46565167
74	CAMKK1	0.45644967
75	PIM1	0.45474128
76	LCK	0.44171536
77	PDK2	0.43005731
78	IKBKB	0.42715247
79	TYRO3	0.40666083
80	DAPK3	0.40089290
81	ALK	0.39573445
82	PAK3	0.39337811
83	TIE1	0.38420489
84	CAMK2B	0.38405271
85	CSNK2A1	0.37181188
86	CAMK2G	0.36403875
87	KIT	0.35028152
88	RIPK4	0.34815524
89	PRKACA	0.34691078
90	CSNK1A1	0.34492458
91	BMPR1B	0.33109068
92	ERBB2	0.32825701
93	PRKACG	0.32232065
94	BRSK1	0.30880701
95	PRKCA	0.30257506
96	CSNK1G2	0.30058554
97	PRKCD	0.29965943
98	EIF2AK1	0.29309618
99	PRKCB	0.28506898
100	ATM	0.27005773

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.50677517
2	RNA polymerase_Homo sapiens_hsa03020	3.11210136
3	One carbon pool by folate_Homo sapiens_hsa00670	3.07277960
4	Ribosome_Homo sapiens_hsa03010	3.05022516
5	Oxidative phosphorylation_Homo sapiens_hsa00190	3.04211094
6	Parkinsons disease_Homo sapiens_hsa05012	2.88377446
7	Phototransduction_Homo sapiens_hsa04744	2.22525989
8	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.19946102
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.03035167
10	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.99313515
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.94824034
12	Allograft rejection_Homo sapiens_hsa05330	1.86127431
13	Huntingtons disease_Homo sapiens_hsa05016	1.85778196
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.78359170
15	Asthma_Homo sapiens_hsa05310	1.77063080
16	Non-homologous end-joining_Homo sapiens_hsa03450	1.76854380
17	Alzheimers disease_Homo sapiens_hsa05010	1.76607758
18	Protein export_Homo sapiens_hsa03060	1.76366849
19	Homologous recombination_Homo sapiens_hsa03440	1.75710204
20	Caffeine metabolism_Homo sapiens_hsa00232	1.74073838
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.68685854
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.68020819
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.61969584
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.56497978
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.53131085
26	Base excision repair_Homo sapiens_hsa03410	1.49632846
27	RNA degradation_Homo sapiens_hsa03018	1.47438394
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.45920577
29	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.45527358
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.42176431
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.41457029
32	DNA replication_Homo sapiens_hsa03030	1.39862878
33	Sulfur relay system_Homo sapiens_hsa04122	1.36490744
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.30027391
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.25974861
36	RNA transport_Homo sapiens_hsa03013	1.25082507
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.24966712
38	Glutathione metabolism_Homo sapiens_hsa00480	1.23707907
39	Basal transcription factors_Homo sapiens_hsa03022	1.20588721
40	Cardiac muscle contraction_Homo sapiens_hsa04260	1.17567730
41	Antigen processing and presentation_Homo sapiens_hsa04612	1.17440106
42	Mismatch repair_Homo sapiens_hsa03430	1.14193112
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.10129757
44	Peroxisome_Homo sapiens_hsa04146	1.08498028
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.07549257
46	Propanoate metabolism_Homo sapiens_hsa00640	1.06690953
47	Purine metabolism_Homo sapiens_hsa00230	1.06139067
48	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.99332267
49	Fat digestion and absorption_Homo sapiens_hsa04975	0.92256221
50	Olfactory transduction_Homo sapiens_hsa04740	0.91577377
51	Spliceosome_Homo sapiens_hsa03040	0.91139131
52	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.90060288
53	Sulfur metabolism_Homo sapiens_hsa00920	0.85759418
54	Retinol metabolism_Homo sapiens_hsa00830	0.85552245
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.84726476
56	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.83840862
57	Tryptophan metabolism_Homo sapiens_hsa00380	0.83617543
58	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.83032611
59	Alcoholism_Homo sapiens_hsa05034	0.81214714
60	Taste transduction_Homo sapiens_hsa04742	0.78252701
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.74947638
62	Nucleotide excision repair_Homo sapiens_hsa03420	0.71665967
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.70422671
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69673294
65	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.69011301
66	Regulation of autophagy_Homo sapiens_hsa04140	0.68465584
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.66520980
68	Butanoate metabolism_Homo sapiens_hsa00650	0.65881843
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.65723534
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.63112636
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.62335276
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62105885
73	Rheumatoid arthritis_Homo sapiens_hsa05323	0.60684851
74	Folate biosynthesis_Homo sapiens_hsa00790	0.60358486
75	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.59964441
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59381599
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58325363
78	Metabolic pathways_Homo sapiens_hsa01100	0.57778246
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.56862719
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54452580
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.54276382
82	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.54166405
83	Fatty acid elongation_Homo sapiens_hsa00062	0.48671496
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.48012186
85	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.46952744
86	Nicotine addiction_Homo sapiens_hsa05033	0.46136290
87	Pyruvate metabolism_Homo sapiens_hsa00620	0.45922022
88	Legionellosis_Homo sapiens_hsa05134	0.41994975
89	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.41043896
90	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.37877593
91	Arginine biosynthesis_Homo sapiens_hsa00220	0.35938926
92	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.32451513
93	p53 signaling pathway_Homo sapiens_hsa04115	0.32270237
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.32242350
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.31621985
96	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.29501468
97	Cell cycle_Homo sapiens_hsa04110	0.25629419
98	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.24238322
99	Viral myocarditis_Homo sapiens_hsa05416	0.24112748
100	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.20637528

HNRNPA1P37

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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