ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.44971424
2	DNA deamination (GO:0045006)	6.26269139
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.14291475
4	ATP synthesis coupled proton transport (GO:0015986)	6.14291475
5	chaperone-mediated protein transport (GO:0072321)	4.81423121
6	ribosomal small subunit assembly (GO:0000028)	4.62460472
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.61386259
8	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.58473940
9	rRNA modification (GO:0000154)	4.51510795
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.37207879
11	protein neddylation (GO:0045116)	4.21483047
12	respiratory electron transport chain (GO:0022904)	4.11454231
13	cytidine metabolic process (GO:0046087)	4.11444813
14	cytidine catabolic process (GO:0006216)	4.11444813
15	cytidine deamination (GO:0009972)	4.11444813
16	electron transport chain (GO:0022900)	4.09952668
17	sequestering of actin monomers (GO:0042989)	4.05210942
18	behavioral response to nicotine (GO:0035095)	3.94608078
19	viral transcription (GO:0019083)	3.90172202
20	maturation of SSU-rRNA (GO:0030490)	3.89870198
21	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.88761482
22	translational termination (GO:0006415)	3.86598443
23	proteasome assembly (GO:0043248)	3.85348117
24	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.80561655
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.76534153
26	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.76534153
27	NADH dehydrogenase complex assembly (GO:0010257)	3.76534153
28	protein complex biogenesis (GO:0070271)	3.69546524
29	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.65935567
30	ribosomal large subunit biogenesis (GO:0042273)	3.61321276
31	cotranslational protein targeting to membrane (GO:0006613)	3.58494365
32	mitochondrial respiratory chain complex assembly (GO:0033108)	3.58472687
33	protein targeting to ER (GO:0045047)	3.55520712
34	ATP biosynthetic process (GO:0006754)	3.53701476
35	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.48857740
36	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.46302958
37	translational elongation (GO:0006414)	3.45394093
38	preassembly of GPI anchor in ER membrane (GO:0016254)	3.42007113
39	rRNA methylation (GO:0031167)	3.39693707
40	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.39191389
41	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.37715637
42	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.35251531
43	protein localization to endoplasmic reticulum (GO:0070972)	3.34809324
44	GTP biosynthetic process (GO:0006183)	3.33519242
45	respiratory chain complex IV assembly (GO:0008535)	3.29690534
46	cellular ketone body metabolic process (GO:0046950)	3.28276337
47	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.22448057
48	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.22448057
49	protein deneddylation (GO:0000338)	3.21386776
50	base-excision repair, AP site formation (GO:0006285)	3.20311006
51	translation (GO:0006412)	3.20089775
52	regulation of cellular amino acid metabolic process (GO:0006521)	3.14171076
53	cullin deneddylation (GO:0010388)	3.12825599
54	purine nucleobase biosynthetic process (GO:0009113)	3.12560617
55	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.07951385
56	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.06971129
57	UTP metabolic process (GO:0046051)	3.06466063
58	water-soluble vitamin biosynthetic process (GO:0042364)	3.05043902
59	mannosylation (GO:0097502)	3.03469804
60	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.03031567
61	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.03031567
62	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.03031567
63	oxidative phosphorylation (GO:0006119)	3.01120135
64	response to pheromone (GO:0019236)	2.97354195
65	guanosine-containing compound biosynthetic process (GO:1901070)	2.96438781
66	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.95772539
67	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.95772539
68	pseudouridine synthesis (GO:0001522)	2.93756761
69	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.93433323
70	translational initiation (GO:0006413)	2.93184475
71	spliceosomal snRNP assembly (GO:0000387)	2.92813630
72	ketone body metabolic process (GO:1902224)	2.92099982
73	nucleobase biosynthetic process (GO:0046112)	2.91440642
74	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.90931663
75	negative regulation of ligase activity (GO:0051352)	2.90931663
76	hydrogen ion transmembrane transport (GO:1902600)	2.90107611
77	cellular protein complex disassembly (GO:0043624)	2.89988409
78	cytochrome complex assembly (GO:0017004)	2.89342945
79	UTP biosynthetic process (GO:0006228)	2.89300160
80	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.89230834
81	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.89149635
82	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.88676193
83	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.88676193
84	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.87088839
85	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.87088839
86	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.86011026
87	negative regulation of telomere maintenance (GO:0032205)	2.82197805
88	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.82003428
89	termination of RNA polymerase III transcription (GO:0006386)	2.82003428
90	rRNA processing (GO:0006364)	2.82002076
91	cellular component biogenesis (GO:0044085)	2.81719921
92	chromatin remodeling at centromere (GO:0031055)	2.81279739
93	intracellular protein transmembrane import (GO:0044743)	2.78735918
94	GPI anchor metabolic process (GO:0006505)	2.78633461
95	nucleoside triphosphate biosynthetic process (GO:0009142)	2.78453722
96	viral life cycle (GO:0019058)	2.77909065
97	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.77182130
98	rRNA metabolic process (GO:0016072)	2.76308908
99	indolalkylamine metabolic process (GO:0006586)	2.76004641
100	CENP-A containing nucleosome assembly (GO:0034080)	2.75236750

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.37685342
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.32283039
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.83565371
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.54949507
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.34555635
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.27544983
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.20443780
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.83705396
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.75881774
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.63579936
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.55810836
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.48784833
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.43171128
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.41984690
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.41591343
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.38386883
17	VDR_22108803_ChIP-Seq_LS180_Human	2.36701284
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.35378979
19	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.25548589
20	EZH2_22144423_ChIP-Seq_EOC_Human	2.25445768
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.15961904
22	FOXP3_21729870_ChIP-Seq_TREG_Human	2.05560256
23	IGF1R_20145208_ChIP-Seq_DFB_Human	1.89700667
24	EWS_26573619_Chip-Seq_HEK293_Human	1.89283849
25	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.86571579
26	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.84096439
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.80539046
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.74971962
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.73960617
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.71907400
31	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.68527541
32	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.62490134
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.59120565
34	E2F7_22180533_ChIP-Seq_HELA_Human	1.55703814
35	FUS_26573619_Chip-Seq_HEK293_Human	1.53417091
36	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.52510297
37	TTF2_22483619_ChIP-Seq_HELA_Human	1.49617994
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49055405
39	DCP1A_22483619_ChIP-Seq_HELA_Human	1.46215028
40	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.43247431
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.41616004
42	P300_19829295_ChIP-Seq_ESCs_Human	1.40179372
43	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.38079099
44	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.35797045
45	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.35055152
46	ER_23166858_ChIP-Seq_MCF-7_Human	1.34560933
47	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33160608
48	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.31027514
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.27829178
50	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.27687852
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26683674
52	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.26593897
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26335868
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26335868
55	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.26081928
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25823486
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25823486
58	GABP_19822575_ChIP-Seq_HepG2_Human	1.25130225
59	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.24617673
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23322154
61	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.23279730
62	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.21980132
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.17980053
64	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.16986136
65	IRF1_19129219_ChIP-ChIP_H3396_Human	1.13687149
66	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.13431870
67	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.13355631
68	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.11925553
69	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.10009308
70	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.09759785
71	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.08973151
72	AR_20517297_ChIP-Seq_VCAP_Human	1.08613752
73	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.06272577
74	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03080244
75	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.02472645
76	XRN2_22483619_ChIP-Seq_HELA_Human	1.02287490
77	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01936011
78	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.01213722
79	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.00939340
80	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.98865826
81	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.97522728
82	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.97481564
83	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.97100712
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96612160
85	ERG_20517297_ChIP-Seq_VCAP_Human	0.93786289
86	HTT_18923047_ChIP-ChIP_STHdh_Human	0.93361389
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.93214659
88	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.92549607
89	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.91455802
90	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.91217404
91	NCOR_22424771_ChIP-Seq_293T_Human	0.90557667
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.89581439
93	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.89454705
94	CBP_20019798_ChIP-Seq_JUKART_Human	0.89454705
95	TCF4_22108803_ChIP-Seq_LS180_Human	0.88213698
96	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.87913432
97	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.86200360
98	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.85647999
99	HOXB7_26014856_ChIP-Seq_BT474_Human	0.84824658
100	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.84306869

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.54073227
2	MP0006292_abnormal_olfactory_placode	3.53563780
3	MP0002102_abnormal_ear_morphology	2.67797511
4	MP0004147_increased_porphyrin_level	2.54552230
5	MP0005671_abnormal_response_to	2.49206520
6	MP0008877_abnormal_DNA_methylation	2.41292685
7	MP0008995_early_reproductive_senescence	2.15143416
8	MP0005084_abnormal_gallbladder_morpholo	2.13949061
9	MP0006072_abnormal_retinal_apoptosis	2.07151209
10	MP0002736_abnormal_nociception_after	2.04087352
11	MP0001529_abnormal_vocalization	2.02953278
12	MP0008875_abnormal_xenobiotic_pharmacok	1.97945316
13	MP0008058_abnormal_DNA_repair	1.95014319
14	MP0001293_anophthalmia	1.92736098
15	MP0008872_abnormal_physiological_respon	1.90426787
16	MP0002234_abnormal_pharynx_morphology	1.87563019
17	MP0003011_delayed_dark_adaptation	1.87217874
18	MP0002277_abnormal_respiratory_mucosa	1.84958388
19	MP0003786_premature_aging	1.83141891
20	MP0002938_white_spotting	1.78379491
21	MP0001485_abnormal_pinna_reflex	1.71330047
22	MP0005646_abnormal_pituitary_gland	1.70795006
23	MP0005551_abnormal_eye_electrophysiolog	1.68464489
24	MP0003136_yellow_coat_color	1.64264986
25	MP0003283_abnormal_digestive_organ	1.62966333
26	MP0005645_abnormal_hypothalamus_physiol	1.59475589
27	MP0004885_abnormal_endolymph	1.58841023
28	MP0003693_abnormal_embryo_hatching	1.57934141
29	MP0003718_maternal_effect	1.50235211
30	MP0004957_abnormal_blastocyst_morpholog	1.47716181
31	MP0001968_abnormal_touch/_nociception	1.47388868
32	MP0003787_abnormal_imprinting	1.46570761
33	MP0001835_abnormal_antigen_presentation	1.46200612
34	MP0003195_calcinosis	1.43776961
35	MP0010094_abnormal_chromosome_stability	1.38871643
36	MP0009785_altered_susceptibility_to	1.38569098
37	MP0002653_abnormal_ependyma_morphology	1.38389341
38	MP0000631_abnormal_neuroendocrine_gland	1.37269080
39	MP0000049_abnormal_middle_ear	1.31717190
40	MP0006036_abnormal_mitochondrial_physio	1.28013041
41	MP0004142_abnormal_muscle_tone	1.27020613
42	MP0005253_abnormal_eye_physiology	1.26310158
43	MP0009333_abnormal_splenocyte_physiolog	1.22463815
44	MP0002837_dystrophic_cardiac_calcinosis	1.19665831
45	MP0001905_abnormal_dopamine_level	1.14312560
46	MP0000372_irregular_coat_pigmentation	1.13198729
47	MP0003567_abnormal_fetal_cardiomyocyte	1.12196025
48	MP0003646_muscle_fatigue	1.12069295
49	MP0001873_stomach_inflammation	1.10492034
50	MP0003938_abnormal_ear_development	1.09140158
51	MP0002822_catalepsy	1.08414208
52	MP0003186_abnormal_redox_activity	1.06998189
53	MP0003121_genomic_imprinting	1.05570215
54	MP0002272_abnormal_nervous_system	1.05323843
55	MP0009697_abnormal_copulation	1.03867411
56	MP0002751_abnormal_autonomic_nervous	1.03617237
57	MP0005389_reproductive_system_phenotype	1.03359767
58	MP0002160_abnormal_reproductive_system	1.02814080
59	MP0005085_abnormal_gallbladder_physiolo	1.02655207
60	MP0005379_endocrine/exocrine_gland_phen	1.02509104
61	MP0008789_abnormal_olfactory_epithelium	1.01861397
62	MP0003111_abnormal_nucleus_morphology	0.97560018
63	MP0006035_abnormal_mitochondrial_morpho	0.95620845
64	MP0001986_abnormal_taste_sensitivity	0.94841505
65	MP0005377_hearing/vestibular/ear_phenot	0.94837668
66	MP0003878_abnormal_ear_physiology	0.94837668
67	MP0008007_abnormal_cellular_replicative	0.93600327
68	MP0001348_abnormal_lacrimal_gland	0.92708912
69	MP0006276_abnormal_autonomic_nervous	0.92458210
70	MP0005636_abnormal_mineral_homeostasis	0.87783307
71	MP0004145_abnormal_muscle_electrophysio	0.86888790
72	MP0002282_abnormal_trachea_morphology	0.85992289
73	MP0002148_abnormal_hypersensitivity_rea	0.85867403
74	MP0002095_abnormal_skin_pigmentation	0.85857716
75	MP0001963_abnormal_hearing_physiology	0.85733882
76	MP0005195_abnormal_posterior_eye	0.85330445
77	MP0000026_abnormal_inner_ear	0.85131974
78	MP0001919_abnormal_reproductive_system	0.84518550
79	MP0001501_abnormal_sleep_pattern	0.84393830
80	MP0002210_abnormal_sex_determination	0.84010895
81	MP0004742_abnormal_vestibular_system	0.83617814
82	MP0003077_abnormal_cell_cycle	0.81678757
83	MP0003119_abnormal_digestive_system	0.79998316
84	MP0003880_abnormal_central_pattern	0.79991432
85	MP0001929_abnormal_gametogenesis	0.79972723
86	MP0009745_abnormal_behavioral_response	0.73751544
87	MP0001486_abnormal_startle_reflex	0.73047401
88	MP0002163_abnormal_gland_morphology	0.72330375
89	MP0003937_abnormal_limbs/digits/tail_de	0.71689859
90	MP0008775_abnormal_heart_ventricle	0.71551629
91	MP0008057_abnormal_DNA_replication	0.71060290
92	MP0002735_abnormal_chemical_nociception	0.70388649
93	MP0001286_abnormal_eye_development	0.69539636
94	MP0009764_decreased_sensitivity_to	0.69069594
95	MP0002876_abnormal_thyroid_physiology	0.68329983
96	MP0000685_abnormal_immune_system	0.68214133
97	MP0002733_abnormal_thermal_nociception	0.67827216
98	MP0001119_abnormal_female_reproductive	0.66975190
99	MP0002752_abnormal_somatic_nervous	0.66969954
100	MP0001145_abnormal_male_reproductive	0.66941778

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Mitochondrial inheritance (HP:0001427)	4.06203586
2	Acute necrotizing encephalopathy (HP:0006965)	4.04357610
3	3-Methylglutaconic aciduria (HP:0003535)	3.92892034
4	Increased CSF lactate (HP:0002490)	3.82053634
5	Acute encephalopathy (HP:0006846)	3.76599694
6	Hepatocellular necrosis (HP:0001404)	3.70501684
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.47520428
8	Increased hepatocellular lipid droplets (HP:0006565)	3.41822267
9	Methylmalonic acidemia (HP:0002912)	3.40174600
10	Hepatic necrosis (HP:0002605)	3.24013404
11	Progressive macrocephaly (HP:0004481)	3.22358150
12	Lipid accumulation in hepatocytes (HP:0006561)	3.03443703
13	Pancreatic cysts (HP:0001737)	2.98973129
14	Cerebral edema (HP:0002181)	2.93624463
15	Reticulocytopenia (HP:0001896)	2.85950696
16	Pancreatic fibrosis (HP:0100732)	2.77662930
17	Pancytopenia (HP:0001876)	2.76575937
18	Aplastic anemia (HP:0001915)	2.75179497
19	Methylmalonic aciduria (HP:0012120)	2.65891218
20	Type I transferrin isoform profile (HP:0003642)	2.59198517
21	Renal Fanconi syndrome (HP:0001994)	2.55191462
22	Macrocytic anemia (HP:0001972)	2.52030382
23	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.48486435
24	Optic disc pallor (HP:0000543)	2.48459233
25	True hermaphroditism (HP:0010459)	2.46816450
26	Increased serum lactate (HP:0002151)	2.44552992
27	Hypoproteinemia (HP:0003075)	2.43168680
28	B lymphocytopenia (HP:0010976)	2.35294139
29	Septo-optic dysplasia (HP:0100842)	2.35214678
30	Molar tooth sign on MRI (HP:0002419)	2.33999017
31	Abnormality of midbrain morphology (HP:0002418)	2.33999017
32	IgG deficiency (HP:0004315)	2.33913121
33	Abnormal number of erythroid precursors (HP:0012131)	2.32626564
34	Lactic acidosis (HP:0003128)	2.31693626
35	Abnormality of cells of the erythroid lineage (HP:0012130)	2.27700296
36	Abnormal protein glycosylation (HP:0012346)	2.26952538
37	Abnormal glycosylation (HP:0012345)	2.26952538
38	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.26952538
39	Abnormal protein N-linked glycosylation (HP:0012347)	2.26952538
40	Abnormality of B cell number (HP:0010975)	2.25821343
41	Hyperglycinemia (HP:0002154)	2.24804788
42	Colon cancer (HP:0003003)	2.23651876
43	Congenital, generalized hypertrichosis (HP:0004540)	2.22801344
44	Testicular atrophy (HP:0000029)	2.19914129
45	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.19641206
46	Pendular nystagmus (HP:0012043)	2.19201113
47	Type 2 muscle fiber atrophy (HP:0003554)	2.18447122
48	Exertional dyspnea (HP:0002875)	2.18238724
49	Abolished electroretinogram (ERG) (HP:0000550)	2.17833889
50	Abnormality of alanine metabolism (HP:0010916)	2.15895335
51	Hyperalaninemia (HP:0003348)	2.15895335
52	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.15895335
53	Congenital stationary night blindness (HP:0007642)	2.14326732
54	Abnormality of the renal collecting system (HP:0004742)	2.13496345
55	Renal cortical cysts (HP:0000803)	2.13028880
56	CNS demyelination (HP:0007305)	2.12977488
57	Attenuation of retinal blood vessels (HP:0007843)	2.11264040
58	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.10847469
59	Dicarboxylic aciduria (HP:0003215)	2.10847469
60	Lethargy (HP:0001254)	2.08973490
61	Abnormality of the labia minora (HP:0012880)	2.06449582
62	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.05507900
63	Bilateral microphthalmos (HP:0007633)	2.04306738
64	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.04292566
65	Duplicated collecting system (HP:0000081)	2.00494988
66	Abnormality of the renal cortex (HP:0011035)	1.99162899
67	Respiratory failure (HP:0002878)	1.98996635
68	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.98367028
69	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.98089018
70	Nephronophthisis (HP:0000090)	1.97155539
71	Abnormality of the ileum (HP:0001549)	1.96599519
72	Sclerocornea (HP:0000647)	1.95545123
73	Large eyes (HP:0001090)	1.95497525
74	Anophthalmia (HP:0000528)	1.95371593
75	Asplenia (HP:0001746)	1.94944738
76	Chronic hepatic failure (HP:0100626)	1.93910705
77	Meckel diverticulum (HP:0002245)	1.93589916
78	Emotional lability (HP:0000712)	1.93354119
79	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.92486120
80	Increased intramyocellular lipid droplets (HP:0012240)	1.90631753
81	Abnormality of the prostate (HP:0008775)	1.90176737
82	Abnormal respiratory motile cilium physiology (HP:0012261)	1.89479653
83	Duodenal stenosis (HP:0100867)	1.89354285
84	Small intestinal stenosis (HP:0012848)	1.89354285
85	Absent thumb (HP:0009777)	1.88556065
86	Muscle fiber atrophy (HP:0100295)	1.87521930
87	Supernumerary spleens (HP:0009799)	1.84151817
88	Abnormality of vitamin B metabolism (HP:0004340)	1.82968115
89	Stomatitis (HP:0010280)	1.82874033
90	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.81820512
91	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.81528671
92	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.81528671
93	Leukodystrophy (HP:0002415)	1.79614706
94	Carpal bone hypoplasia (HP:0001498)	1.78783042
95	Constricted visual fields (HP:0001133)	1.78742658
96	Microvesicular hepatic steatosis (HP:0001414)	1.77972838
97	Autoimmune hemolytic anemia (HP:0001890)	1.77659176
98	Pallor (HP:0000980)	1.77196431
99	Abnormality of the pons (HP:0007361)	1.75183373
100	Reduced antithrombin III activity (HP:0001976)	1.74968252

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	4.13906581
2	BCKDK	3.89454049
3	VRK2	3.48589853
4	BUB1	3.08255801
5	TLK1	3.07617740
6	MAP4K2	2.98023864
7	ADRBK2	2.56494746
8	TXK	2.46779148
9	STK16	2.46130013
10	VRK1	2.26313208
11	WNK3	2.17688302
12	MKNK1	2.14266770
13	TIE1	2.08011716
14	MST4	1.97169581
15	GRK1	1.91247957
16	BMPR1B	1.79050639
17	TSSK6	1.73922717
18	NUAK1	1.71669213
19	TAOK3	1.67136374
20	WNK4	1.51935234
21	DYRK2	1.42984199
22	NEK1	1.34081515
23	NME1	1.33587081
24	PINK1	1.32172584
25	PLK3	1.29533886
26	PASK	1.22484425
27	OXSR1	1.20666283
28	SRPK1	1.19628022
29	EIF2AK3	1.18276313
30	TNIK	1.09676728
31	ACVR1B	1.08621534
32	PBK	1.02205884
33	KIT	1.02153480
34	TGFBR1	1.00272864
35	TEC	0.99842537
36	KDR	0.96123302
37	CDK19	0.94749035
38	CDC7	0.94284537
39	CSNK1G3	0.90308413
40	FLT3	0.87443004
41	STK39	0.84402732
42	ITK	0.82886939
43	WEE1	0.82282192
44	EPHA4	0.81644134
45	PLK1	0.79961202
46	IKBKE	0.79618444
47	CSNK1G1	0.78624280
48	AURKB	0.78381020
49	RPS6KA5	0.77405549
50	RPS6KA4	0.77284508
51	INSRR	0.75520806
52	TRIM28	0.75423527
53	MKNK2	0.74457943
54	FRK	0.74103478
55	MAP4K1	0.74023714
56	DYRK3	0.73734830
57	PLK4	0.73411574
58	TTK	0.72384652
59	CSNK1G2	0.72307150
60	IKBKB	0.71696892
61	PDK2	0.71294755
62	CHEK2	0.71209382
63	ATR	0.70196341
64	CSNK1A1	0.67258125
65	TESK2	0.67103858
66	MAPK13	0.66367670
67	TAF1	0.64981730
68	CSNK1A1L	0.63337238
69	ADRBK1	0.62502890
70	MAP3K12	0.60671330
71	CSNK2A1	0.60236301
72	BRSK2	0.58916697
73	ERBB3	0.56730914
74	CSNK2A2	0.56281820
75	PHKG2	0.55344769
76	PHKG1	0.55344769
77	PKN1	0.54904665
78	MYLK	0.54061002
79	BCR	0.53789543
80	OBSCN	0.53757789
81	DAPK1	0.51659741
82	DAPK2	0.51647334
83	EIF2AK2	0.51547549
84	NME2	0.51448657
85	GRK7	0.50471518
86	EIF2AK1	0.47910078
87	STK4	0.47551511
88	PRKCG	0.45513873
89	SYK	0.45325464
90	DAPK3	0.41244473
91	PRKACA	0.38324962
92	AURKA	0.37985886
93	PIK3CG	0.37328963
94	PIM1	0.37145084
95	MAPKAPK5	0.36030654
96	GRK6	0.35930277
97	NTRK2	0.34869285
98	EPHB2	0.34713963
99	BTK	0.34008906
100	PRKCA	0.32591506

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.18162098
2	Ribosome_Homo sapiens_hsa03010	3.77213457
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.66570559
4	Parkinsons disease_Homo sapiens_hsa05012	3.14342883
5	Protein export_Homo sapiens_hsa03060	2.70327194
6	RNA polymerase_Homo sapiens_hsa03020	2.57269354
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.49519239
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.47133470
9	Homologous recombination_Homo sapiens_hsa03440	2.22635884
10	Huntingtons disease_Homo sapiens_hsa05016	2.13539828
11	DNA replication_Homo sapiens_hsa03030	2.10067632
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.09673857
13	Mismatch repair_Homo sapiens_hsa03430	2.09023247
14	Alzheimers disease_Homo sapiens_hsa05010	1.98915420
15	Spliceosome_Homo sapiens_hsa03040	1.96430368
16	Base excision repair_Homo sapiens_hsa03410	1.90538296
17	One carbon pool by folate_Homo sapiens_hsa00670	1.89549556
18	Propanoate metabolism_Homo sapiens_hsa00640	1.74369978
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.64809637
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.61907471
21	Asthma_Homo sapiens_hsa05310	1.61832452
22	RNA degradation_Homo sapiens_hsa03018	1.61181156
23	Nucleotide excision repair_Homo sapiens_hsa03420	1.57778659
24	Allograft rejection_Homo sapiens_hsa05330	1.52581513
25	Primary immunodeficiency_Homo sapiens_hsa05340	1.49564949
26	RNA transport_Homo sapiens_hsa03013	1.48846297
27	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.48037498
28	Basal transcription factors_Homo sapiens_hsa03022	1.47493906
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.44431353
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.39920862
31	Type I diabetes mellitus_Homo sapiens_hsa04940	1.26333917
32	Purine metabolism_Homo sapiens_hsa00230	1.24798269
33	Graft-versus-host disease_Homo sapiens_hsa05332	1.22656997
34	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.22128175
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.21198042
36	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.19652599
37	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.12828631
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.12005344
39	Phototransduction_Homo sapiens_hsa04744	1.11376791
40	Linoleic acid metabolism_Homo sapiens_hsa00591	1.10433856
41	Butanoate metabolism_Homo sapiens_hsa00650	1.08639549
42	Selenocompound metabolism_Homo sapiens_hsa00450	1.04135368
43	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.99843495
44	Peroxisome_Homo sapiens_hsa04146	0.95122138
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.93514421
46	Sulfur metabolism_Homo sapiens_hsa00920	0.92786626
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.90182673
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89894815
49	Nitrogen metabolism_Homo sapiens_hsa00910	0.76811381
50	Antigen processing and presentation_Homo sapiens_hsa04612	0.75134625
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74412979
52	Retinol metabolism_Homo sapiens_hsa00830	0.74382206
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.74367575
54	Histidine metabolism_Homo sapiens_hsa00340	0.74101994
55	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.73304609
56	Metabolic pathways_Homo sapiens_hsa01100	0.72382770
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.71650897
58	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.69399804
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67596732
60	Rheumatoid arthritis_Homo sapiens_hsa05323	0.67146767
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65777433
62	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.65661453
63	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.60978401
64	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.60098851
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.59048134
66	Taste transduction_Homo sapiens_hsa04742	0.58439203
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57574663
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57089525
69	Caffeine metabolism_Homo sapiens_hsa00232	0.56104539
70	Non-homologous end-joining_Homo sapiens_hsa03450	0.55852151
71	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.55690886
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54212557
73	Glutathione metabolism_Homo sapiens_hsa00480	0.54010810
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51815667
75	Nicotine addiction_Homo sapiens_hsa05033	0.50434981
76	Fatty acid elongation_Homo sapiens_hsa00062	0.49959119
77	Pyruvate metabolism_Homo sapiens_hsa00620	0.49917056
78	Olfactory transduction_Homo sapiens_hsa04740	0.49469599
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49014218
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48957616
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.47632328
82	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.47588486
83	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.47070510
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.46943079
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.46419918
86	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.44150015
87	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.41475757
88	Cell cycle_Homo sapiens_hsa04110	0.40108822
89	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.35155380
90	mRNA surveillance pathway_Homo sapiens_hsa03015	0.33023699
91	Fatty acid degradation_Homo sapiens_hsa00071	0.32954226
92	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.32608926
93	p53 signaling pathway_Homo sapiens_hsa04115	0.32083153
94	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.31091928
95	Regulation of autophagy_Homo sapiens_hsa04140	0.27765997
96	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.26079085
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.25476242
98	Oocyte meiosis_Homo sapiens_hsa04114	0.24299716
99	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.24061313
100	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.23787495

HNRNPA1P38

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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