ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.11655462
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.15233551
3	sequestering of actin monomers (GO:0042989)	4.51455690
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.49048970
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.36274883
6	ATP synthesis coupled proton transport (GO:0015986)	4.36274883
7	cytidine deamination (GO:0009972)	4.23682641
8	cytidine metabolic process (GO:0046087)	4.23682641
9	cytidine catabolic process (GO:0006216)	4.23682641
10	protein neddylation (GO:0045116)	4.07944717
11	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.84741950
12	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.68860788
13	protein deneddylation (GO:0000338)	3.68547178
14	chaperone-mediated protein transport (GO:0072321)	3.66515079
15	ribosomal small subunit assembly (GO:0000028)	3.63493913
16	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.62055935
17	proteasome assembly (GO:0043248)	3.58677892
18	cullin deneddylation (GO:0010388)	3.58610661
19	respiratory electron transport chain (GO:0022904)	3.54680495
20	electron transport chain (GO:0022900)	3.53516356
21	protein complex biogenesis (GO:0070271)	3.47101067
22	positive regulation of prostaglandin secretion (GO:0032308)	3.47021002
23	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.42958509
24	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.38252600
25	regulation of cellular amino acid metabolic process (GO:0006521)	3.37851490
26	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.36636436
27	metallo-sulfur cluster assembly (GO:0031163)	3.34913190
28	iron-sulfur cluster assembly (GO:0016226)	3.34913190
29	mitochondrial respiratory chain complex assembly (GO:0033108)	3.27739247
30	platelet dense granule organization (GO:0060155)	3.26572368
31	water-soluble vitamin biosynthetic process (GO:0042364)	3.25148498
32	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.18211573
33	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.18211573
34	mannosylation (GO:0097502)	3.15711123
35	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.14000222
36	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.11962663
37	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.08195143
38	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.08195143
39	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.08195143
40	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.07021566
41	NADH dehydrogenase complex assembly (GO:0010257)	3.07021566
42	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.07021566
43	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.02123143
44	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.02123143
45	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.99541396
46	termination of RNA polymerase III transcription (GO:0006386)	2.99233627
47	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.99233627
48	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.97023089
49	kynurenine metabolic process (GO:0070189)	2.93259056
50	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.91707037
51	negative regulation of T cell apoptotic process (GO:0070233)	2.91674386
52	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.90947065
53	negative regulation of ligase activity (GO:0051352)	2.90947065
54	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.90470523
55	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.90470523
56	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.89168672
57	protein-cofactor linkage (GO:0018065)	2.87237153
58	tryptophan metabolic process (GO:0006568)	2.86167741
59	rRNA modification (GO:0000154)	2.84367240
60	indole-containing compound catabolic process (GO:0042436)	2.84262084
61	indolalkylamine catabolic process (GO:0046218)	2.84262084
62	tryptophan catabolic process (GO:0006569)	2.84262084
63	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.84136469
64	purine deoxyribonucleotide catabolic process (GO:0009155)	2.83551703
65	oxidative phosphorylation (GO:0006119)	2.81602481
66	regulation of chronic inflammatory response (GO:0002676)	2.81310833
67	actin nucleation (GO:0045010)	2.80931857
68	response to interferon-beta (GO:0035456)	2.80712703
69	indolalkylamine metabolic process (GO:0006586)	2.80385581
70	negative regulation by host of viral transcription (GO:0043922)	2.79069890
71	cytochrome complex assembly (GO:0017004)	2.77587993
72	positive regulation of fatty acid transport (GO:2000193)	2.76336939
73	respiratory chain complex IV assembly (GO:0008535)	2.72163835
74	response to pheromone (GO:0019236)	2.70741430
75	cellular response to interleukin-15 (GO:0071350)	2.70469952
76	positive regulation of icosanoid secretion (GO:0032305)	2.67477505
77	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.65843817
78	regulation of regulatory T cell differentiation (GO:0045589)	2.64275660
79	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.62958102
80	hydrogen ion transmembrane transport (GO:1902600)	2.62055377
81	base-excision repair, AP site formation (GO:0006285)	2.61605496
82	regulation of prostaglandin secretion (GO:0032306)	2.61531100
83	DNA catabolic process, exonucleolytic (GO:0000738)	2.60064823
84	positive regulation of interleukin-8 secretion (GO:2000484)	2.58071965
85	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.57562547
86	DNA double-strand break processing (GO:0000729)	2.57351263
87	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.57073645
88	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.56470153
89	proton transport (GO:0015992)	2.55189282
90	regulation of mitotic spindle checkpoint (GO:1903504)	2.54671759
91	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.54671759
92	pseudouridine synthesis (GO:0001522)	2.53612698
93	regulation of mitochondrial translation (GO:0070129)	2.53089057
94	negative T cell selection (GO:0043383)	2.50949161
95	GPI anchor metabolic process (GO:0006505)	2.50741471
96	hydrogen transport (GO:0006818)	2.50662433
97	regulation of T cell receptor signaling pathway (GO:0050856)	2.49930246
98	protein polyglutamylation (GO:0018095)	2.49244666
99	cytolysis (GO:0019835)	2.49160664
100	S-adenosylmethionine metabolic process (GO:0046500)	2.48751666

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.22409176
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.94425687
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.77614941
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.47396673
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.45558384
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.11817452
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.08760306
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.95962440
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.90983439
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.71950158
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.67127755
12	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.39284936
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.39165528
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.37112202
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.29063633
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.27207082
17	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.24442143
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.23956697
19	VDR_22108803_ChIP-Seq_LS180_Human	2.17855727
20	FOXP3_21729870_ChIP-Seq_TREG_Human	2.10526541
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.05610976
22	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.95241955
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.91717893
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.91356185
25	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.89572751
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.86924300
27	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.86430347
28	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.83020787
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.80295844
30	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.59779628
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.57059134
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.54110756
33	EWS_26573619_Chip-Seq_HEK293_Human	1.54097184
34	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.50997934
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.50141393
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.45720832
37	FUS_26573619_Chip-Seq_HEK293_Human	1.35300877
38	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.34807032
39	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.34645177
40	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.33105933
41	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.32865984
42	AR_20517297_ChIP-Seq_VCAP_Human	1.30655392
43	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.30030480
44	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.29304454
45	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.29019244
46	GATA3_26560356_Chip-Seq_TH2_Human	1.28734869
47	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.28613230
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28186320
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28186320
50	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.27216505
51	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.26099563
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.25446488
53	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.25383337
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.25332595
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25272979
56	DCP1A_22483619_ChIP-Seq_HELA_Human	1.24707467
57	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.23606202
58	MYB_26560356_Chip-Seq_TH2_Human	1.19482956
59	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.18443578
60	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17727359
61	ER_23166858_ChIP-Seq_MCF-7_Human	1.17500921
62	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16985653
63	GABP_19822575_ChIP-Seq_HepG2_Human	1.16781832
64	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.16597359
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15704376
66	P300_19829295_ChIP-Seq_ESCs_Human	1.15572041
67	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.12528129
68	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.12105774
69	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.11967561
70	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.11804368
71	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10509060
72	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08384586
73	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.08198562
74	CBP_20019798_ChIP-Seq_JUKART_Human	1.08198562
75	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08188569
76	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.07660629
77	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.07259131
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05886564
79	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.05652913
80	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.04715648
81	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04509608
82	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04509608
83	TTF2_22483619_ChIP-Seq_HELA_Human	1.03583297
84	NCOR_22424771_ChIP-Seq_293T_Human	1.02843002
85	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.02842668
86	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02803611
87	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.02065170
88	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.00750653
89	ERG_20517297_ChIP-Seq_VCAP_Human	1.00298806
90	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.98572516
91	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.98524609
92	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.98151850
93	GATA3_27048872_Chip-Seq_THYMUS_Human	0.98127987
94	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.97969535
95	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.97929102
96	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.96821939
97	EZH2_22144423_ChIP-Seq_EOC_Human	0.96158892
98	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95377310
99	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.94681459
100	CIITA_25753668_ChIP-Seq_RAJI_Human	0.93535000

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.24599826
2	MP0006072_abnormal_retinal_apoptosis	3.20200265
3	MP0006292_abnormal_olfactory_placode	2.62405250
4	MP0008875_abnormal_xenobiotic_pharmacok	2.41300332
5	MP0001835_abnormal_antigen_presentation	2.25605660
6	MP0009785_altered_susceptibility_to	2.18799890
7	MP0004147_increased_porphyrin_level	2.14042905
8	MP0003786_premature_aging	2.07953730
9	MP0008995_early_reproductive_senescence	2.06842277
10	MP0002102_abnormal_ear_morphology	2.00432198
11	MP0005084_abnormal_gallbladder_morpholo	1.99691066
12	MP0000372_irregular_coat_pigmentation	1.99350003
13	MP0003011_delayed_dark_adaptation	1.88761445
14	MP0003195_calcinosis	1.88756876
15	MP0005551_abnormal_eye_electrophysiolog	1.87214906
16	MP0008058_abnormal_DNA_repair	1.86811188
17	MP0005253_abnormal_eye_physiology	1.86562449
18	MP0005645_abnormal_hypothalamus_physiol	1.83679630
19	MP0008872_abnormal_physiological_respon	1.81690934
20	MP0003763_abnormal_thymus_physiology	1.80423777
21	MP0002653_abnormal_ependyma_morphology	1.67547535
22	MP0005646_abnormal_pituitary_gland	1.67333975
23	MP0001968_abnormal_touch/_nociception	1.59194391
24	MP0003878_abnormal_ear_physiology	1.57784181
25	MP0005377_hearing/vestibular/ear_phenot	1.57784181
26	MP0008877_abnormal_DNA_methylation	1.57186698
27	MP0008789_abnormal_olfactory_epithelium	1.56293982
28	MP0001986_abnormal_taste_sensitivity	1.54802320
29	MP0002006_tumorigenesis	1.52095088
30	MP0001529_abnormal_vocalization	1.51676591
31	MP0002736_abnormal_nociception_after	1.51624408
32	MP0002166_altered_tumor_susceptibility	1.50107842
33	MP0001764_abnormal_homeostasis	1.49207113
34	MP0001984_abnormal_olfaction	1.48127731
35	MP0005000_abnormal_immune_tolerance	1.46465248
36	MP0002148_abnormal_hypersensitivity_rea	1.43151097
37	MP0003866_abnormal_defecation	1.39452691
38	MP0001800_abnormal_humoral_immune	1.37701699
39	MP0000685_abnormal_immune_system	1.35404237
40	MP0001905_abnormal_dopamine_level	1.34761733
41	MP0005389_reproductive_system_phenotype	1.29893293
42	MP0003724_increased_susceptibility_to	1.27362636
43	MP0002723_abnormal_immune_serum	1.24603926
44	MP0010386_abnormal_urinary_bladder	1.23997734
45	MP0006036_abnormal_mitochondrial_physio	1.23461237
46	MP0001919_abnormal_reproductive_system	1.21553123
47	MP0002420_abnormal_adaptive_immunity	1.20771082
48	MP0002234_abnormal_pharynx_morphology	1.20020282
49	MP0003252_abnormal_bile_duct	1.19698989
50	MP0002277_abnormal_respiratory_mucosa	1.19510085
51	MP0001819_abnormal_immune_cell	1.18884541
52	MP0001873_stomach_inflammation	1.16952918
53	MP0002837_dystrophic_cardiac_calcinosis	1.16166856
54	MP0005075_abnormal_melanosome_morpholog	1.11045754
55	MP0005025_abnormal_response_to	1.10864152
56	MP0003880_abnormal_central_pattern	1.07981101
57	MP0006276_abnormal_autonomic_nervous	1.07693318
58	MP0002638_abnormal_pupillary_reflex	1.06107406
59	MP0003646_muscle_fatigue	1.05716618
60	MP0005387_immune_system_phenotype	1.05075387
61	MP0001790_abnormal_immune_system	1.05075387
62	MP0004142_abnormal_muscle_tone	1.04188238
63	MP0006035_abnormal_mitochondrial_morpho	1.04094767
64	MP0005085_abnormal_gallbladder_physiolo	1.03085485
65	MP0002160_abnormal_reproductive_system	1.02783289
66	MP0000689_abnormal_spleen_morphology	1.02712656
67	MP0004885_abnormal_endolymph	1.01881582
68	MP0002876_abnormal_thyroid_physiology	1.01537812
69	MP0004145_abnormal_muscle_electrophysio	1.01299997
70	MP0003806_abnormal_nucleotide_metabolis	1.01235662
71	MP0000716_abnormal_immune_system	1.00698869
72	MP0000703_abnormal_thymus_morphology	0.99085818
73	MP0009333_abnormal_splenocyte_physiolog	0.98807335
74	MP0002452_abnormal_antigen_presenting	0.98193451
75	MP0002398_abnormal_bone_marrow	0.97359648
76	MP0009697_abnormal_copulation	0.96155096
77	MP0005499_abnormal_olfactory_system	0.95954329
78	MP0005394_taste/olfaction_phenotype	0.95954329
79	MP0002722_abnormal_immune_system	0.95750273
80	MP0005167_abnormal_blood-brain_barrier	0.95064089
81	MP0003718_maternal_effect	0.93202693
82	MP0000631_abnormal_neuroendocrine_gland	0.91884657
83	MP0002933_joint_inflammation	0.91106479
84	MP0000465_gastrointestinal_hemorrhage	0.90288342
85	MP0003137_abnormal_impulse_conducting	0.89712546
86	MP0002405_respiratory_system_inflammati	0.88965402
87	MP0001501_abnormal_sleep_pattern	0.88806131
88	MP0005410_abnormal_fertilization	0.86482573
89	MP0001485_abnormal_pinna_reflex	0.85731726
90	MP0004043_abnormal_pH_regulation	0.85369340
91	MP0010094_abnormal_chromosome_stability	0.84949987
92	MP0002751_abnormal_autonomic_nervous	0.82485105
93	MP0003436_decreased_susceptibility_to	0.82282018
94	MP0009764_decreased_sensitivity_to	0.81798908
95	MP0004133_heterotaxia	0.81142926
96	MP0009745_abnormal_behavioral_response	0.80408682
97	MP0002095_abnormal_skin_pigmentation	0.80322966
98	MP0002272_abnormal_nervous_system	0.78451467
99	MP0002429_abnormal_blood_cell	0.76978196
100	MP0010155_abnormal_intestine_physiology	0.76084380

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Mitochondrial inheritance (HP:0001427)	4.01822631
2	3-Methylglutaconic aciduria (HP:0003535)	3.85491755
3	Severe combined immunodeficiency (HP:0004430)	3.80916467
4	Acute necrotizing encephalopathy (HP:0006965)	3.80797745
5	Hepatocellular necrosis (HP:0001404)	3.73551043
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.56454630
7	Increased CSF lactate (HP:0002490)	3.43213997
8	Pancreatic cysts (HP:0001737)	3.41849366
9	Hepatic necrosis (HP:0002605)	3.41253843
10	Congenital stationary night blindness (HP:0007642)	3.39914823
11	IgG deficiency (HP:0004315)	3.38433975
12	True hermaphroditism (HP:0010459)	3.32882070
13	Increased hepatocellular lipid droplets (HP:0006565)	3.25139627
14	Acute encephalopathy (HP:0006846)	3.22310238
15	Aplastic anemia (HP:0001915)	3.17059628
16	Pancreatic fibrosis (HP:0100732)	3.16912016
17	Progressive macrocephaly (HP:0004481)	3.08016059
18	Lipid accumulation in hepatocytes (HP:0006561)	3.06108307
19	Methylmalonic acidemia (HP:0002912)	3.01277374
20	Thyroiditis (HP:0100646)	2.96977606
21	Combined immunodeficiency (HP:0005387)	2.94615463
22	T lymphocytopenia (HP:0005403)	2.90153462
23	Elevated erythrocyte sedimentation rate (HP:0003565)	2.88895337
24	Increased intramyocellular lipid droplets (HP:0012240)	2.88158663
25	Abnormality of T cell number (HP:0011839)	2.86230302
26	Colon cancer (HP:0003003)	2.84932568
27	Hypoproteinemia (HP:0003075)	2.82187561
28	Abnormality of B cell number (HP:0010975)	2.80450894
29	Renal cortical cysts (HP:0000803)	2.78916871
30	Abolished electroretinogram (ERG) (HP:0000550)	2.72247635
31	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.70946214
32	Renal Fanconi syndrome (HP:0001994)	2.64230104
33	Nephronophthisis (HP:0000090)	2.60604873
34	Cerebral edema (HP:0002181)	2.60321415
35	Methylmalonic aciduria (HP:0012120)	2.58798088
36	Attenuation of retinal blood vessels (HP:0007843)	2.57274513
37	Type I transferrin isoform profile (HP:0003642)	2.52851139
38	Increased serum lactate (HP:0002151)	2.51886282
39	Abnormality of T cells (HP:0002843)	2.49758317
40	Optic disc pallor (HP:0000543)	2.48949530
41	Molar tooth sign on MRI (HP:0002419)	2.45721436
42	Abnormality of midbrain morphology (HP:0002418)	2.45721436
43	Abnormality of eosinophils (HP:0001879)	2.44709903
44	Pancytopenia (HP:0001876)	2.43382884
45	Stomach cancer (HP:0012126)	2.43075461
46	Lactic acidosis (HP:0003128)	2.41891151
47	Increased muscle lipid content (HP:0009058)	2.40252073
48	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.36819618
49	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.36819618
50	Abnormal protein glycosylation (HP:0012346)	2.36149631
51	Abnormal glycosylation (HP:0012345)	2.36149631
52	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.36149631
53	Abnormal protein N-linked glycosylation (HP:0012347)	2.36149631
54	Abnormal rod and cone electroretinograms (HP:0008323)	2.35585197
55	B lymphocytopenia (HP:0010976)	2.31498247
56	Abnormality of the prostate (HP:0008775)	2.28718576
57	Aplasia/hypoplasia of the uterus (HP:0008684)	2.28035938
58	Abnormality of the renal cortex (HP:0011035)	2.27351369
59	Medial flaring of the eyebrow (HP:0010747)	2.26170519
60	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.25875715
61	Dicarboxylic aciduria (HP:0003215)	2.25875715
62	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.24025180
63	Hyperglycinemia (HP:0002154)	2.22497015
64	Type 2 muscle fiber atrophy (HP:0003554)	2.18636715
65	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.17476165
66	Respiratory failure (HP:0002878)	2.13474115
67	Exertional dyspnea (HP:0002875)	2.12750003
68	Increased IgM level (HP:0003496)	2.12659438
69	Abnormality of the renal medulla (HP:0100957)	2.11694071
70	Lethargy (HP:0001254)	2.07772624
71	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.07521029
72	Abnormality of alanine metabolism (HP:0010916)	2.07521029
73	Hyperalaninemia (HP:0003348)	2.07521029
74	Stomatitis (HP:0010280)	2.04625565
75	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.02337886
76	Decreased central vision (HP:0007663)	2.02205299
77	Autoimmune hemolytic anemia (HP:0001890)	2.01342314
78	Abnormal biliary tract physiology (HP:0012439)	2.01202936
79	Bile duct proliferation (HP:0001408)	2.01202936
80	Hypoplasia of the uterus (HP:0000013)	2.00885675
81	Sclerocornea (HP:0000647)	1.98529976
82	Generalized aminoaciduria (HP:0002909)	1.95552230
83	Cerebral palsy (HP:0100021)	1.94983270
84	Autoimmune thrombocytopenia (HP:0001973)	1.92917518
85	Pendular nystagmus (HP:0012043)	1.91957434
86	Encephalitis (HP:0002383)	1.91045297
87	Abnormal number of erythroid precursors (HP:0012131)	1.90806839
88	Congenital, generalized hypertrichosis (HP:0004540)	1.88186522
89	Thyroid-stimulating hormone excess (HP:0002925)	1.87329480
90	Muscle fiber atrophy (HP:0100295)	1.86968451
91	Abnormality of serum amino acid levels (HP:0003112)	1.86460052
92	Eosinophilia (HP:0001880)	1.85355401
93	IgM deficiency (HP:0002850)	1.84613355
94	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.83723360
95	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.82654402
96	Abnormality of the labia minora (HP:0012880)	1.82213106
97	Abnormality of T cell physiology (HP:0011840)	1.81883769
98	Exercise intolerance (HP:0003546)	1.81434153
99	Cystic liver disease (HP:0006706)	1.81019917
100	Panhypogammaglobulinemia (HP:0003139)	1.80175880

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	4.41077546
2	TXK	4.33661303
3	MAP4K2	4.12999460
4	ZAK	3.55652847
5	VRK2	3.26951465
6	KDR	3.14755397
7	BCKDK	2.59675708
8	TAOK3	2.55608976
9	TLK1	2.51232049
10	ADRBK2	2.34186536
11	NUAK1	2.15614197
12	GRK1	2.02399984
13	VRK1	1.94553105
14	BUB1	1.59031379
15	MAP4K1	1.52210207
16	MST4	1.48009741
17	ITK	1.39564469
18	SRPK1	1.35834553
19	PINK1	1.32086025
20	STK16	1.28316811
21	EIF2AK3	1.23338678
22	LIMK1	1.22007061
23	WNK3	1.21660402
24	PASK	1.19039984
25	FRK	1.18917030
26	TRIM28	1.14060579
27	BMPR1B	1.12946201
28	TEC	1.08108797
29	WNK4	1.06997990
30	GRK6	1.06319688
31	NME1	1.05089049
32	MKNK1	1.04678849
33	TAF1	1.02025624
34	CSNK1G3	1.00012413
35	PBK	0.99227901
36	KIT	0.97583711
37	ERBB3	0.92462355
38	RPS6KA5	0.91427581
39	CDK19	0.89021796
40	DYRK2	0.86205452
41	SYK	0.82326387
42	BCR	0.80078902
43	OXSR1	0.79601149
44	PRKCQ	0.78924165
45	TIE1	0.78772005
46	CSNK1A1L	0.78396291
47	EIF2AK2	0.78223858
48	CSNK1G1	0.77433933
49	TESK1	0.76100757
50	MAP2K7	0.75403944
51	PLK3	0.75331391
52	DAPK1	0.74939654
53	CSNK1G2	0.74660387
54	IKBKE	0.72946176
55	IKBKB	0.72285193
56	MAPK13	0.70700260
57	EPHA4	0.69904460
58	LCK	0.68746788
59	MAP3K12	0.66300907
60	INSRR	0.65533235
61	GRK7	0.64938516
62	MAP2K2	0.64156098
63	CAMKK2	0.63431077
64	FES	0.61765777
65	NEK1	0.60833902
66	LYN	0.60660594
67	RPS6KA4	0.60627828
68	CDC7	0.60435462
69	CSF1R	0.56406673
70	PLK4	0.55631333
71	GRK5	0.55436476
72	FLT3	0.54074281
73	MATK	0.53985375
74	ATR	0.51008244
75	TBK1	0.50631475
76	ADRBK1	0.50339703
77	BTK	0.46503826
78	SCYL2	0.45656345
79	IGF1R	0.45035179
80	BRSK2	0.44975029
81	PLK2	0.44730177
82	MAP3K4	0.42852026
83	AURKB	0.41507454
84	TSSK6	0.41122897
85	CSNK1A1	0.41013065
86	PKN1	0.40425835
87	CSNK2A1	0.39748451
88	PLK1	0.39698562
89	STK39	0.37174239
90	OBSCN	0.36724600
91	CDK8	0.35648140
92	ZAP70	0.35131393
93	PIM1	0.35126284
94	TNK2	0.34833169
95	MAP2K6	0.33984975
96	AURKA	0.33924556
97	PIK3CG	0.32876671
98	JAK3	0.31163563
99	CSNK2A2	0.30019752
100	PRKCA	0.29587759

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.32689818
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.44120847
3	Primary immunodeficiency_Homo sapiens_hsa05340	3.19343815
4	Parkinsons disease_Homo sapiens_hsa05012	2.94768875
5	RNA polymerase_Homo sapiens_hsa03020	2.49331247
6	Protein export_Homo sapiens_hsa03060	2.41220374
7	Ribosome_Homo sapiens_hsa03010	2.36294748
8	Caffeine metabolism_Homo sapiens_hsa00232	2.14365297
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.04902172
10	Huntingtons disease_Homo sapiens_hsa05016	1.82827190
11	Alzheimers disease_Homo sapiens_hsa05010	1.79383312
12	Homologous recombination_Homo sapiens_hsa03440	1.77510537
13	Graft-versus-host disease_Homo sapiens_hsa05332	1.71015266
14	Allograft rejection_Homo sapiens_hsa05330	1.69524600
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.67624152
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.65410152
17	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.64576467
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.64383628
19	Antigen processing and presentation_Homo sapiens_hsa04612	1.61194739
20	Phototransduction_Homo sapiens_hsa04744	1.60769917
21	Mismatch repair_Homo sapiens_hsa03430	1.54094835
22	Propanoate metabolism_Homo sapiens_hsa00640	1.50483719
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.49218167
24	DNA replication_Homo sapiens_hsa03030	1.49000227
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.46518438
26	Spliceosome_Homo sapiens_hsa03040	1.45867454
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.44663891
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.44588233
29	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.43696647
30	RNA degradation_Homo sapiens_hsa03018	1.38237630
31	Asthma_Homo sapiens_hsa05310	1.36380759
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.30733340
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.30344044
34	Butanoate metabolism_Homo sapiens_hsa00650	1.28454343
35	Basal transcription factors_Homo sapiens_hsa03022	1.28102945
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.25315606
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.22961863
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.21979521
39	Base excision repair_Homo sapiens_hsa03410	1.21004854
40	One carbon pool by folate_Homo sapiens_hsa00670	1.19462961
41	Peroxisome_Homo sapiens_hsa04146	1.16671030
42	Linoleic acid metabolism_Homo sapiens_hsa00591	1.15694271
43	Nucleotide excision repair_Homo sapiens_hsa03420	1.15605027
44	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.15134045
45	Sulfur metabolism_Homo sapiens_hsa00920	1.11310560
46	Rheumatoid arthritis_Homo sapiens_hsa05323	1.07255290
47	Purine metabolism_Homo sapiens_hsa00230	1.06985509
48	Fatty acid elongation_Homo sapiens_hsa00062	1.03622177
49	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.00238716
50	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.00068545
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.97332037
52	Non-homologous end-joining_Homo sapiens_hsa03450	0.91668512
53	Retinol metabolism_Homo sapiens_hsa00830	0.91135713
54	RNA transport_Homo sapiens_hsa03013	0.90273968
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.86373457
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.84536554
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.82675119
58	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.80601465
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77806218
60	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.77162302
61	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.75453264
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74558347
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.72636708
64	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.69180981
65	Metabolic pathways_Homo sapiens_hsa01100	0.68120058
66	Selenocompound metabolism_Homo sapiens_hsa00450	0.66168444
67	Olfactory transduction_Homo sapiens_hsa04740	0.64942243
68	Glutathione metabolism_Homo sapiens_hsa00480	0.64777448
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62504041
70	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.61369280
71	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.59974444
72	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.59158604
73	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.58333786
74	Steroid biosynthesis_Homo sapiens_hsa00100	0.56282154
75	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.55384887
76	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.54252130
77	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53986343
78	Regulation of autophagy_Homo sapiens_hsa04140	0.53201150
79	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.52585173
80	Nicotine addiction_Homo sapiens_hsa05033	0.52462156
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.52063727
82	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.48938795
83	Taste transduction_Homo sapiens_hsa04742	0.48508615
84	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.47500018
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45935972
86	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.45282021
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43179441
88	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.42286254
89	Folate biosynthesis_Homo sapiens_hsa00790	0.40970735
90	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.38887301
91	Ether lipid metabolism_Homo sapiens_hsa00565	0.38549192
92	Fatty acid degradation_Homo sapiens_hsa00071	0.36407619
93	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.35327976
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.35312565
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.33173338
96	Sulfur relay system_Homo sapiens_hsa04122	0.32829206
97	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.32763556
98	Fat digestion and absorption_Homo sapiens_hsa04975	0.32468362
99	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.32442821
100	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.31641631

HNRNPA1P39

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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