ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.49548068
2	sequestering of actin monomers (GO:0042989)	5.11995121
3	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.67389009
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.65746828
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.36040752
6	ATP synthesis coupled proton transport (GO:0015986)	4.36040752
7	platelet dense granule organization (GO:0060155)	4.23586407
8	ribosomal small subunit assembly (GO:0000028)	4.18949171
9	cytidine deamination (GO:0009972)	3.94769931
10	cytidine metabolic process (GO:0046087)	3.94769931
11	cytidine catabolic process (GO:0006216)	3.94769931
12	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.74575922
13	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.74575922
14	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.71249026
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.67487347
16	protein neddylation (GO:0045116)	3.63965191
17	cellular response to interleukin-15 (GO:0071350)	3.62145368
18	behavioral response to nicotine (GO:0035095)	3.54733437
19	respiratory electron transport chain (GO:0022904)	3.48671476
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.47207676
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.47207676
22	NADH dehydrogenase complex assembly (GO:0010257)	3.47207676
23	electron transport chain (GO:0022900)	3.45706633
24	protein complex biogenesis (GO:0070271)	3.44173203
25	base-excision repair, AP site formation (GO:0006285)	3.39655336
26	mitochondrial respiratory chain complex assembly (GO:0033108)	3.33735834
27	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.24834129
28	proteasome assembly (GO:0043248)	3.20600485
29	regulation of chronic inflammatory response (GO:0002676)	3.19649351
30	regulation of female receptivity (GO:0045924)	3.15787977
31	regulation of T cell receptor signaling pathway (GO:0050856)	3.12439719
32	negative regulation of T cell receptor signaling pathway (GO:0050860)	3.11303001
33	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.10125594
34	water-soluble vitamin biosynthetic process (GO:0042364)	3.09695025
35	termination of RNA polymerase III transcription (GO:0006386)	3.07810355
36	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.07810355
37	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.06146363
38	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	3.05525504
39	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.03267775
40	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.03267775
41	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.03267775
42	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.01403760
43	regulation of cellular amino acid metabolic process (GO:0006521)	2.98961360
44	respiratory chain complex IV assembly (GO:0008535)	2.96585108
45	positive regulation of prostaglandin secretion (GO:0032308)	2.96319204
46	mast cell activation (GO:0045576)	2.95071535
47	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.94866292
48	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.94866292
49	negative regulation by host of viral transcription (GO:0043922)	2.87388385
50	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.87121836
51	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.87121836
52	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.85382541
53	mast cell activation involved in immune response (GO:0002279)	2.81917441
54	mast cell degranulation (GO:0043303)	2.81917441
55	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.80823761
56	response to interleukin-15 (GO:0070672)	2.80558878
57	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.78731372
58	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.77749269
59	viral transcription (GO:0019083)	2.75206383
60	translational termination (GO:0006415)	2.74079283
61	regulation of T cell mediated cytotoxicity (GO:0001914)	2.73770606
62	negative regulation of T cell apoptotic process (GO:0070233)	2.73768108
63	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.73365339
64	purine deoxyribonucleotide catabolic process (GO:0009155)	2.72899258
65	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.72392568
66	inner mitochondrial membrane organization (GO:0007007)	2.72303641
67	positive regulation of defense response to virus by host (GO:0002230)	2.72288623
68	regulation of B cell receptor signaling pathway (GO:0050855)	2.72157773
69	female mating behavior (GO:0060180)	2.71972196
70	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.69333365
71	S-adenosylmethionine metabolic process (GO:0046500)	2.69019842
72	cytochrome complex assembly (GO:0017004)	2.68778402
73	iron-sulfur cluster assembly (GO:0016226)	2.66567817
74	metallo-sulfur cluster assembly (GO:0031163)	2.66567817
75	kynurenine metabolic process (GO:0070189)	2.66059532
76	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.65518236
77	negative regulation of ligase activity (GO:0051352)	2.64848158
78	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.64848158
79	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.64274064
80	hydrogen ion transmembrane transport (GO:1902600)	2.64084211
81	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.61872288
82	cotranslational protein targeting to membrane (GO:0006613)	2.61360700
83	protein targeting to ER (GO:0045047)	2.59696646
84	proton transport (GO:0015992)	2.59123383
85	L-methionine salvage (GO:0071267)	2.58649094
86	L-methionine biosynthetic process (GO:0071265)	2.58649094
87	amino acid salvage (GO:0043102)	2.58649094
88	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.57370365
89	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.56849737
90	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.56730660
91	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.56384316
92	ribosomal large subunit biogenesis (GO:0042273)	2.56107516
93	L-fucose catabolic process (GO:0042355)	2.56075813
94	fucose catabolic process (GO:0019317)	2.56075813
95	L-fucose metabolic process (GO:0042354)	2.56075813
96	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.55297007
97	translational elongation (GO:0006414)	2.54970777
98	hydrogen transport (GO:0006818)	2.54740718
99	rRNA modification (GO:0000154)	2.52992967
100	ATP biosynthetic process (GO:0006754)	2.52274173

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.89204180
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.68102397
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.36836022
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.89854828
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.84771039
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.74472648
7	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.71515964
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.58278724
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.57639069
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.56065308
11	VDR_22108803_ChIP-Seq_LS180_Human	2.53756916
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.53068889
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.47424357
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.26726027
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.25454386
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.22356932
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.22129517
18	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.10293680
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.09874798
20	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.04552366
21	FOXP3_21729870_ChIP-Seq_TREG_Human	2.03369297
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.98572987
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.84662682
24	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.83719587
25	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.83482901
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.81253925
27	IGF1R_20145208_ChIP-Seq_DFB_Human	1.78766469
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76443066
29	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.74744141
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.74173672
31	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.71310882
32	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.66540049
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66253631
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.63280750
35	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.60406311
36	TAF15_26573619_Chip-Seq_HEK293_Human	1.59827354
37	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.59082126
38	GATA3_26560356_Chip-Seq_TH2_Human	1.56899034
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56419238
40	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.54171082
41	EWS_26573619_Chip-Seq_HEK293_Human	1.53925718
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.49443164
43	AR_20517297_ChIP-Seq_VCAP_Human	1.46838007
44	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.43325689
45	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.42383804
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.41603118
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.41603118
48	MYB_26560356_Chip-Seq_TH2_Human	1.40141895
49	FUS_26573619_Chip-Seq_HEK293_Human	1.39674343
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36790507
51	EZH2_22144423_ChIP-Seq_EOC_Human	1.35326856
52	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.33065773
53	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.30263381
54	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.29778887
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.27794531
56	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.26554858
57	P300_19829295_ChIP-Seq_ESCs_Human	1.24750566
58	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.23448695
59	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21684433
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21195312
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21195312
62	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.20861545
63	NCOR_22424771_ChIP-Seq_293T_Human	1.18586645
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18018782
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15314349
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14194247
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.13874595
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.13874595
69	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.12611243
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12476107
71	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.12341254
72	RUNX_20019798_ChIP-Seq_JUKART_Human	1.12079391
73	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.11208860
74	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.11175850
75	HTT_18923047_ChIP-ChIP_STHdh_Human	1.08684984
76	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.08648755
77	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.07751448
78	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07295265
79	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.06724796
80	IRF1_19129219_ChIP-ChIP_H3396_Human	1.06369647
81	ERG_20517297_ChIP-Seq_VCAP_Human	1.05312290
82	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.03814978
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03325874
84	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.03144224
85	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.02723498
86	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01842195
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99580685
88	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99488202
89	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.99450005
90	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.98181316
91	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97904791
92	TTF2_22483619_ChIP-Seq_HELA_Human	0.97231011
93	HOXB7_26014856_ChIP-Seq_BT474_Human	0.96789513
94	GATA3_27048872_Chip-Seq_THYMUS_Human	0.94622659
95	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94142143
96	TAF2_19829295_ChIP-Seq_ESCs_Human	0.93090092
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92765612
98	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.91694961
99	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.91510052
100	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.90926527

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.84494228
2	MP0000372_irregular_coat_pigmentation	3.34078587
3	MP0006072_abnormal_retinal_apoptosis	3.05139612
4	MP0003136_yellow_coat_color	2.89209427
5	MP0008877_abnormal_DNA_methylation	2.71377415
6	MP0004885_abnormal_endolymph	2.47572529
7	MP0002102_abnormal_ear_morphology	2.40301477
8	MP0005551_abnormal_eye_electrophysiolog	2.15290729
9	MP0006292_abnormal_olfactory_placode	2.08090286
10	MP0004147_increased_porphyrin_level	1.97574985
11	MP0008875_abnormal_xenobiotic_pharmacok	1.97261501
12	MP0009379_abnormal_foot_pigmentation	1.90595999
13	MP0005253_abnormal_eye_physiology	1.86820293
14	MP0003011_delayed_dark_adaptation	1.86181937
15	MP0008872_abnormal_physiological_respon	1.83778817
16	MP0009785_altered_susceptibility_to	1.78436622
17	MP0002736_abnormal_nociception_after	1.76826234
18	MP0001835_abnormal_antigen_presentation	1.75943705
19	MP0001986_abnormal_taste_sensitivity	1.71753832
20	MP0002876_abnormal_thyroid_physiology	1.63081641
21	MP0002234_abnormal_pharynx_morphology	1.63076657
22	MP0001800_abnormal_humoral_immune	1.60107174
23	MP0002148_abnormal_hypersensitivity_rea	1.57653600
24	MP0005075_abnormal_melanosome_morpholog	1.57075003
25	MP0005645_abnormal_hypothalamus_physiol	1.56370357
26	MP0003646_muscle_fatigue	1.53451516
27	MP0005000_abnormal_immune_tolerance	1.53259095
28	MP0005646_abnormal_pituitary_gland	1.52469872
29	MP0002163_abnormal_gland_morphology	1.49938967
30	MP0003878_abnormal_ear_physiology	1.49653959
31	MP0005377_hearing/vestibular/ear_phenot	1.49653959
32	MP0004142_abnormal_muscle_tone	1.49114398
33	MP0003866_abnormal_defecation	1.46519396
34	MP0003763_abnormal_thymus_physiology	1.40055970
35	MP0002277_abnormal_respiratory_mucosa	1.39033554
36	MP0009333_abnormal_splenocyte_physiolog	1.38935444
37	MP0001968_abnormal_touch/_nociception	1.37736331
38	MP0003283_abnormal_digestive_organ	1.34652460
39	MP0000685_abnormal_immune_system	1.33339550
40	MP0008995_early_reproductive_senescence	1.33160654
41	MP0002723_abnormal_immune_serum	1.32794249
42	MP0004742_abnormal_vestibular_system	1.30582959
43	MP0001873_stomach_inflammation	1.30543144
44	MP0003806_abnormal_nucleotide_metabolis	1.30307391
45	MP0005084_abnormal_gallbladder_morpholo	1.27553927
46	MP0002166_altered_tumor_susceptibility	1.27037515
47	MP0003567_abnormal_fetal_cardiomyocyte	1.26529223
48	MP0002006_tumorigenesis	1.25964254
49	MP0003938_abnormal_ear_development	1.24246436
50	MP0002638_abnormal_pupillary_reflex	1.19560354
51	MP0002420_abnormal_adaptive_immunity	1.18818663
52	MP0001819_abnormal_immune_cell	1.18640214
53	MP0003195_calcinosis	1.17756115
54	MP0002938_white_spotting	1.16045148
55	MP0008058_abnormal_DNA_repair	1.15719748
56	MP0001764_abnormal_homeostasis	1.15028434
57	MP0005387_immune_system_phenotype	1.13274621
58	MP0001790_abnormal_immune_system	1.13274621
59	MP0004145_abnormal_muscle_electrophysio	1.13128966
60	MP0001501_abnormal_sleep_pattern	1.12675513
61	MP0000631_abnormal_neuroendocrine_gland	1.10972129
62	MP0002095_abnormal_skin_pigmentation	1.09455881
63	MP0004381_abnormal_hair_follicle	1.07201404
64	MP0005379_endocrine/exocrine_gland_phen	1.06821749
65	MP0002933_joint_inflammation	1.06554517
66	MP0002452_abnormal_antigen_presenting	1.05430645
67	MP0001485_abnormal_pinna_reflex	1.04631347
68	MP0003718_maternal_effect	1.03972127
69	MP0003724_increased_susceptibility_to	1.02454305
70	MP0003786_premature_aging	1.02418410
71	MP0001919_abnormal_reproductive_system	1.01919802
72	MP0005025_abnormal_response_to	0.97618187
73	MP0009697_abnormal_copulation	0.97102167
74	MP0006276_abnormal_autonomic_nervous	0.94273111
75	MP0001905_abnormal_dopamine_level	0.94007330
76	MP0001293_anophthalmia	0.92330907
77	MP0000647_abnormal_sebaceous_gland	0.92137943
78	MP0006035_abnormal_mitochondrial_morpho	0.90953152
79	MP0005085_abnormal_gallbladder_physiolo	0.90023836
80	MP0000716_abnormal_immune_system	0.89783424
81	MP0005410_abnormal_fertilization	0.88793324
82	MP0006036_abnormal_mitochondrial_physio	0.86486833
83	MP0000689_abnormal_spleen_morphology	0.86371737
84	MP0000049_abnormal_middle_ear	0.85826931
85	MP0002751_abnormal_autonomic_nervous	0.85784769
86	MP0009745_abnormal_behavioral_response	0.85573242
87	MP0002398_abnormal_bone_marrow	0.83635458
88	MP0003119_abnormal_digestive_system	0.82620039
89	MP0000703_abnormal_thymus_morphology	0.81360652
90	MP0001984_abnormal_olfaction	0.81316947
91	MP0002272_abnormal_nervous_system	0.79113075
92	MP0003693_abnormal_embryo_hatching	0.78586757
93	MP0000383_abnormal_hair_follicle	0.78499801
94	MP0008961_abnormal_basal_metabolism	0.78371012
95	MP0003638_abnormal_response/metabolism_	0.78064278
96	MP0005389_reproductive_system_phenotype	0.77747072
97	MP0009764_decreased_sensitivity_to	0.75603055
98	MP0003436_decreased_susceptibility_to	0.74834158
99	MP0002132_abnormal_respiratory_system	0.74293095
100	MP0010155_abnormal_intestine_physiology	0.74105116

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.35174175
2	Stomach cancer (HP:0012126)	4.09605709
3	IgG deficiency (HP:0004315)	3.68051819
4	Mitochondrial inheritance (HP:0001427)	3.64059398
5	Aplastic anemia (HP:0001915)	3.59656794
6	Acute necrotizing encephalopathy (HP:0006965)	3.48145115
7	Pancreatic cysts (HP:0001737)	3.41275932
8	Severe combined immunodeficiency (HP:0004430)	3.40173624
9	True hermaphroditism (HP:0010459)	3.39810620
10	3-Methylglutaconic aciduria (HP:0003535)	3.39696543
11	Hepatocellular necrosis (HP:0001404)	3.37168037
12	Increased CSF lactate (HP:0002490)	3.21433463
13	Colon cancer (HP:0003003)	3.13107526
14	Increased hepatocellular lipid droplets (HP:0006565)	3.05611500
15	Hepatic necrosis (HP:0002605)	3.04348688
16	Abnormal mitochondria in muscle tissue (HP:0008316)	3.00109042
17	Thyroiditis (HP:0100646)	2.98411467
18	Pancreatic fibrosis (HP:0100732)	2.95498009
19	Lipid accumulation in hepatocytes (HP:0006561)	2.93203019
20	Abnormality of B cell number (HP:0010975)	2.91913969
21	Acute encephalopathy (HP:0006846)	2.89713848
22	Progressive macrocephaly (HP:0004481)	2.89653192
23	Hypoproteinemia (HP:0003075)	2.78143823
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.76401449
25	Abnormality of T cell number (HP:0011839)	2.72116162
26	Abnormality of midbrain morphology (HP:0002418)	2.71757817
27	Molar tooth sign on MRI (HP:0002419)	2.71757817
28	Thyroid-stimulating hormone excess (HP:0002925)	2.68606809
29	Congenital, generalized hypertrichosis (HP:0004540)	2.67745347
30	Combined immunodeficiency (HP:0005387)	2.62716623
31	Renal cortical cysts (HP:0000803)	2.59449293
32	T lymphocytopenia (HP:0005403)	2.55711332
33	Methylmalonic acidemia (HP:0002912)	2.51613148
34	Attenuation of retinal blood vessels (HP:0007843)	2.50753282
35	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.48133889
36	Abolished electroretinogram (ERG) (HP:0000550)	2.44427136
37	Renal Fanconi syndrome (HP:0001994)	2.39273947
38	Abnormality of eosinophils (HP:0001879)	2.38104077
39	Abnormality of the pons (HP:0007361)	2.36138446
40	Abnormality of the prostate (HP:0008775)	2.35823136
41	Increased serum lactate (HP:0002151)	2.35803127
42	Optic disc pallor (HP:0000543)	2.33138314
43	Pancytopenia (HP:0001876)	2.32390854
44	Concave nail (HP:0001598)	2.31339535
45	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.31131102
46	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.31131102
47	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.31019609
48	Abnormality of alanine metabolism (HP:0010916)	2.31019609
49	Hyperalaninemia (HP:0003348)	2.31019609
50	Abnormality of the renal cortex (HP:0011035)	2.30427716
51	Cerebral edema (HP:0002181)	2.30077446
52	Methylmalonic aciduria (HP:0012120)	2.24062306
53	Increased intramyocellular lipid droplets (HP:0012240)	2.23304810
54	Lactic acidosis (HP:0003128)	2.22832170
55	B lymphocytopenia (HP:0010976)	2.19308651
56	Abnormality of T cells (HP:0002843)	2.19194115
57	Type II lissencephaly (HP:0007260)	2.17367857
58	Abnormal number of erythroid precursors (HP:0012131)	2.17076566
59	Short tibia (HP:0005736)	2.15104855
60	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.14876092
61	Reticulocytopenia (HP:0001896)	2.12713118
62	Increased IgM level (HP:0003496)	2.12693516
63	Elevated erythrocyte sedimentation rate (HP:0003565)	2.10599819
64	Sclerocornea (HP:0000647)	2.06397589
65	Hypoplasia of the pons (HP:0012110)	2.06183502
66	Medial flaring of the eyebrow (HP:0010747)	2.04177290
67	Prostate neoplasm (HP:0100787)	2.02790862
68	Respiratory difficulties (HP:0002880)	2.00890382
69	Nephronophthisis (HP:0000090)	1.99076269
70	Abnormality of the renal collecting system (HP:0004742)	1.97097056
71	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.96618017
72	Aplasia/hypoplasia of the uterus (HP:0008684)	1.96249646
73	Type 2 muscle fiber atrophy (HP:0003554)	1.94639085
74	Absent thumb (HP:0009777)	1.93668231
75	Decreased central vision (HP:0007663)	1.90965430
76	Cystic liver disease (HP:0006706)	1.89060759
77	Hypoplasia of the uterus (HP:0000013)	1.87869349
78	Conical tooth (HP:0000698)	1.86536886
79	Anencephaly (HP:0002323)	1.86295090
80	Lethargy (HP:0001254)	1.86270037
81	Increased muscle lipid content (HP:0009058)	1.86143446
82	Stomatitis (HP:0010280)	1.85946691
83	Pendular nystagmus (HP:0012043)	1.85011683
84	Postaxial foot polydactyly (HP:0001830)	1.84719072
85	Cerebral palsy (HP:0100021)	1.83648862
86	Oral leukoplakia (HP:0002745)	1.83005849
87	Abnormality of cells of the erythroid lineage (HP:0012130)	1.81060346
88	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.80670152
89	Retinal dysplasia (HP:0007973)	1.80380955
90	Male pseudohermaphroditism (HP:0000037)	1.78909583
91	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.78589679
92	Respiratory failure (HP:0002878)	1.78273644
93	Exertional dyspnea (HP:0002875)	1.78167078
94	Cerebellar dysplasia (HP:0007033)	1.76471632
95	Bilateral microphthalmos (HP:0007633)	1.76346306
96	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.74280377
97	Macrocytic anemia (HP:0001972)	1.74160246
98	IgM deficiency (HP:0002850)	1.72527263
99	Duplicated collecting system (HP:0000081)	1.70413151
100	Anhidrosis (HP:0000970)	1.69445347

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.84136697
2	MAP4K2	4.18021894
3	TESK2	4.04564340
4	ZAK	3.70429412
5	VRK2	3.40038983
6	KDR	2.89866519
7	TLK1	2.78939810
8	ADRBK2	2.43625054
9	BUB1	2.39964086
10	BCKDK	2.23175592
11	PINK1	2.18823311
12	GRK1	2.07662630
13	TAOK3	2.03405854
14	VRK1	1.95426396
15	FRK	1.78139638
16	TAF1	1.76367847
17	NUAK1	1.72964409
18	PASK	1.67119723
19	MST4	1.62768742
20	TSSK6	1.57481570
21	INSRR	1.53652862
22	ITK	1.37600267
23	TIE1	1.32372515
24	CDK19	1.29213510
25	MKNK1	1.25607860
26	MAP4K1	1.23900999
27	SRPK1	1.22830024
28	GRK6	1.18075650
29	MUSK	1.08002066
30	KIT	1.05088416
31	WNK4	1.02950647
32	DYRK2	1.02272380
33	TEC	1.00542491
34	WNK3	0.96624389
35	IKBKB	0.95480515
36	PLK4	0.92573177
37	LIMK1	0.91104735
38	MAP3K12	0.90554021
39	PDK2	0.89692493
40	NME1	0.89319368
41	IKBKE	0.88077355
42	PLK3	0.87982106
43	MATK	0.85488326
44	MAPK13	0.83547775
45	MAP2K2	0.83156762
46	SYK	0.80685242
47	OXSR1	0.79163444
48	CSNK1G3	0.78519037
49	BMPR1B	0.77014342
50	DAPK1	0.76727080
51	FES	0.72758540
52	LCK	0.71615218
53	TRIM28	0.71131869
54	STK16	0.68287435
55	LYN	0.65815923
56	EIF2AK2	0.65760249
57	EIF2AK3	0.65302944
58	RPS6KA5	0.64118347
59	CAMKK2	0.59318815
60	PRKCQ	0.59042302
61	CSNK1G1	0.58749652
62	IGF1R	0.56950505
63	CSNK1G2	0.55187207
64	MAPK15	0.54488885
65	PBK	0.54457431
66	PLK2	0.53296544
67	DAPK2	0.53094734
68	BCR	0.52313830
69	CSNK1A1L	0.51715292
70	ADRBK1	0.50264011
71	CDK8	0.49976353
72	MAPKAPK3	0.49126778
73	ATR	0.45336867
74	GRK7	0.45249392
75	TBK1	0.44751174
76	RPS6KA4	0.42618060
77	MKNK2	0.42375632
78	CSNK2A1	0.41054290
79	ERBB2	0.40043870
80	PIK3CA	0.39545116
81	CDC7	0.38789542
82	MAP2K7	0.38439342
83	MAP3K14	0.37812160
84	PIK3CG	0.36501960
85	PAK3	0.36191170
86	AURKB	0.36106832
87	PIM1	0.35904371
88	CSNK1A1	0.35772371
89	OBSCN	0.35354026
90	CCNB1	0.33989027
91	STK39	0.33377677
92	CSF1R	0.32244525
93	BTK	0.31827109
94	PLK1	0.30440858
95	MYLK	0.30200168
96	PRKCA	0.28310129
97	MAPKAPK5	0.27940514
98	CSNK2A2	0.27402837
99	PRKACA	0.27319931
100	BMPR2	0.27117573

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.13755053
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.45465667
3	Parkinsons disease_Homo sapiens_hsa05012	2.92038019
4	Primary immunodeficiency_Homo sapiens_hsa05340	2.90227753
5	Ribosome_Homo sapiens_hsa03010	2.85422967
6	RNA polymerase_Homo sapiens_hsa03020	2.85177939
7	Protein export_Homo sapiens_hsa03060	2.50193548
8	Homologous recombination_Homo sapiens_hsa03440	2.21752887
9	Phototransduction_Homo sapiens_hsa04744	1.95167378
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.91263846
11	Huntingtons disease_Homo sapiens_hsa05016	1.90788657
12	Caffeine metabolism_Homo sapiens_hsa00232	1.86084177
13	Alzheimers disease_Homo sapiens_hsa05010	1.82242055
14	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.80205251
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.68042578
16	Allograft rejection_Homo sapiens_hsa05330	1.64736075
17	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.63707342
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.58966615
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.54915338
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.54737640
21	Mismatch repair_Homo sapiens_hsa03430	1.52384529
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.47892290
23	Basal transcription factors_Homo sapiens_hsa03022	1.47325525
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.46581295
25	Graft-versus-host disease_Homo sapiens_hsa05332	1.46399518
26	One carbon pool by folate_Homo sapiens_hsa00670	1.44880976
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.41830559
28	RNA degradation_Homo sapiens_hsa03018	1.37060800
29	Antigen processing and presentation_Homo sapiens_hsa04612	1.35552290
30	DNA replication_Homo sapiens_hsa03030	1.34183446
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.31373936
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.29825408
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.29222633
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.28072309
35	Spliceosome_Homo sapiens_hsa03040	1.26363397
36	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.24907050
37	Nucleotide excision repair_Homo sapiens_hsa03420	1.24048006
38	Type I diabetes mellitus_Homo sapiens_hsa04940	1.24024989
39	Purine metabolism_Homo sapiens_hsa00230	1.23507161
40	Base excision repair_Homo sapiens_hsa03410	1.22065551
41	Asthma_Homo sapiens_hsa05310	1.21847493
42	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.19980908
43	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.18451929
44	Sulfur metabolism_Homo sapiens_hsa00920	1.11413130
45	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.10430854
46	Non-homologous end-joining_Homo sapiens_hsa03450	1.01324884
47	Butanoate metabolism_Homo sapiens_hsa00650	1.00311741
48	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.00005882
49	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.99199275
50	RNA transport_Homo sapiens_hsa03013	0.98645863
51	Olfactory transduction_Homo sapiens_hsa04740	0.98571768
52	Propanoate metabolism_Homo sapiens_hsa00640	0.96035876
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.94745385
54	Peroxisome_Homo sapiens_hsa04146	0.91770074
55	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.90442157
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.89908602
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89048941
58	Rheumatoid arthritis_Homo sapiens_hsa05323	0.86843550
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.86377955
60	Retinol metabolism_Homo sapiens_hsa00830	0.86165905
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86147135
62	Nicotine addiction_Homo sapiens_hsa05033	0.77430283
63	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.77421762
64	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.76200791
65	Selenocompound metabolism_Homo sapiens_hsa00450	0.76037006
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.74340922
67	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73792984
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70177605
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70061060
70	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.67549211
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66005650
72	Folate biosynthesis_Homo sapiens_hsa00790	0.64338045
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62682499
74	Metabolic pathways_Homo sapiens_hsa01100	0.61666401
75	Taste transduction_Homo sapiens_hsa04742	0.57597589
76	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.54277301
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53538779
78	Steroid biosynthesis_Homo sapiens_hsa00100	0.52161906
79	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.51794011
80	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.48732702
81	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.46975164
82	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.42752197
83	Morphine addiction_Homo sapiens_hsa05032	0.42476999
84	Ether lipid metabolism_Homo sapiens_hsa00565	0.38932276
85	Collecting duct acid secretion_Homo sapiens_hsa04966	0.38899918
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37518565
87	Glutathione metabolism_Homo sapiens_hsa00480	0.36869849
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.35295888
89	Pyruvate metabolism_Homo sapiens_hsa00620	0.35014600
90	Salivary secretion_Homo sapiens_hsa04970	0.34803548
91	Measles_Homo sapiens_hsa05162	0.33320870
92	ABC transporters_Homo sapiens_hsa02010	0.32940458
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.32754225
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.31314614
95	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.30212805
96	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.30199458
97	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.30179796
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29030470
99	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.28802513
100	Sulfur relay system_Homo sapiens_hsa04122	0.25853899

HNRNPA1P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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