ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.56329436
2	cell proliferation in forebrain (GO:0021846)	4.64600521
3	water-soluble vitamin biosynthetic process (GO:0042364)	4.11313254
4	protein complex biogenesis (GO:0070271)	4.06807654
5	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.01131778
6	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.01131778
7	NADH dehydrogenase complex assembly (GO:0010257)	4.01131778
8	DNA deamination (GO:0045006)	3.74849765
9	parturition (GO:0007567)	3.66844384
10	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.61580644
11	response to pheromone (GO:0019236)	3.58507165
12	protein polyglutamylation (GO:0018095)	3.55526000
13	mitochondrial respiratory chain complex assembly (GO:0033108)	3.55430566
14	protein neddylation (GO:0045116)	3.53328311
15	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.42332108
16	substrate-independent telencephalic tangential migration (GO:0021826)	3.42332108
17	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.41619399
18	ribosomal small subunit biogenesis (GO:0042274)	3.38283556
19	somite development (GO:0061053)	3.35562484
20	kynurenine metabolic process (GO:0070189)	3.34745478
21	negative regulation of appetite (GO:0032099)	3.26839705
22	negative regulation of response to food (GO:0032096)	3.26839705
23	transmission of nerve impulse (GO:0019226)	3.25979322
24	viral transcription (GO:0019083)	3.24115352
25	indolalkylamine metabolic process (GO:0006586)	3.20559037
26	pyrimidine nucleobase catabolic process (GO:0006208)	3.15418599
27	indolalkylamine catabolic process (GO:0046218)	3.14616833
28	tryptophan catabolic process (GO:0006569)	3.14616833
29	indole-containing compound catabolic process (GO:0042436)	3.14616833
30	ribosomal small subunit assembly (GO:0000028)	3.12153053
31	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.11472706
32	endoderm formation (GO:0001706)	3.10641901
33	translational termination (GO:0006415)	3.10290153
34	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.09845500
35	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.05452435
36	ATP synthesis coupled proton transport (GO:0015986)	2.99724015
37	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.99724015
38	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.97700729
39	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.96428934
40	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.96428934
41	synaptic transmission, cholinergic (GO:0007271)	2.95042541
42	epithelial cilium movement (GO:0003351)	2.89551994
43	negative regulation of mast cell activation (GO:0033004)	2.86574802
44	nonmotile primary cilium assembly (GO:0035058)	2.85789209
45	behavioral response to ethanol (GO:0048149)	2.83573346
46	negative regulation of telomere maintenance (GO:0032205)	2.81542258
47	ovulation cycle (GO:0042698)	2.80063814
48	gamma-aminobutyric acid transport (GO:0015812)	2.80013041
49	axoneme assembly (GO:0035082)	2.79318417
50	L-fucose catabolic process (GO:0042355)	2.79054861
51	fucose catabolic process (GO:0019317)	2.79054861
52	L-fucose metabolic process (GO:0042354)	2.79054861
53	negative regulation of systemic arterial blood pressure (GO:0003085)	2.75014443
54	kidney morphogenesis (GO:0060993)	2.72133539
55	amine catabolic process (GO:0009310)	2.72027190
56	cellular biogenic amine catabolic process (GO:0042402)	2.72027190
57	regulation of action potential (GO:0098900)	2.70007683
58	spinal cord development (GO:0021510)	2.69676264
59	adaptation of signaling pathway (GO:0023058)	2.68565089
60	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.67790797
61	positive regulation of T cell apoptotic process (GO:0070234)	2.66658023
62	sulfation (GO:0051923)	2.65358998
63	glycerophospholipid catabolic process (GO:0046475)	2.64208314
64	dentate gyrus development (GO:0021542)	2.64135155
65	regulation of cilium movement (GO:0003352)	2.64005278
66	platelet dense granule organization (GO:0060155)	2.63905876
67	appendage development (GO:0048736)	2.59523522
68	limb development (GO:0060173)	2.59523522
69	spinal cord association neuron differentiation (GO:0021527)	2.59471145
70	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.59037885
71	retinal ganglion cell axon guidance (GO:0031290)	2.58653896
72	nucleobase catabolic process (GO:0046113)	2.58476293
73	translational elongation (GO:0006414)	2.56837050
74	positive regulation of cAMP-mediated signaling (GO:0043950)	2.55893318
75	cytochrome complex assembly (GO:0017004)	2.55318609
76	rhodopsin mediated signaling pathway (GO:0016056)	2.55224196
77	indole-containing compound metabolic process (GO:0042430)	2.53816593
78	primary amino compound metabolic process (GO:1901160)	2.53736134
79	dendritic spine morphogenesis (GO:0060997)	2.53070111
80	negative regulation of astrocyte differentiation (GO:0048712)	2.52598017
81	negative regulation of telomerase activity (GO:0051974)	2.51832830
82	regulation of sequestering of triglyceride (GO:0010889)	2.50893670
83	head development (GO:0060322)	2.50423087
84	cardiovascular system development (GO:0072358)	2.49804057
85	regulation of telomerase activity (GO:0051972)	2.49443463
86	tryptophan metabolic process (GO:0006568)	2.45929227
87	axon ensheathment in central nervous system (GO:0032291)	2.45710900
88	central nervous system myelination (GO:0022010)	2.45710900
89	preassembly of GPI anchor in ER membrane (GO:0016254)	2.44477045
90	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.44403940
91	positive regulation of fatty acid oxidation (GO:0046321)	2.44258652
92	respiratory chain complex IV assembly (GO:0008535)	2.43337109
93	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.43333184
94	chaperone-mediated protein transport (GO:0072321)	2.42415384
95	cotranslational protein targeting to membrane (GO:0006613)	2.42393319
96	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.41853224
97	protein targeting to ER (GO:0045047)	2.41669400
98	regulation of neurotransmitter uptake (GO:0051580)	2.41399359
99	positive regulation of fatty acid transport (GO:2000193)	2.41226797
100	positive regulation of glomerulus development (GO:0090193)	2.40621286

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.73983566
2	ZNF274_21170338_ChIP-Seq_K562_Hela	2.77738401
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.73374150
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.53894162
5	VDR_22108803_ChIP-Seq_LS180_Human	2.38405921
6	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.34839166
7	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.32013467
8	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.29047408
9	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.26784195
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.24546468
11	IRF1_19129219_ChIP-ChIP_H3396_Human	2.13601587
12	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.13185735
13	REST_21632747_ChIP-Seq_MESCs_Mouse	2.11553194
14	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.99531113
15	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.98254026
16	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.91944766
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.90771514
18	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.90322113
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.89291828
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.88730694
21	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.87341209
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.83476171
23	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.82428709
24	RNF2_27304074_Chip-Seq_NSC_Mouse	1.78882949
25	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.75712169
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.73867297
27	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.68350555
28	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.66782192
29	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.64781110
30	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.63554566
31	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.59952241
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59400233
33	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.53867528
34	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.52521704
35	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.52521704
36	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.48960513
37	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.46279779
38	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.43257155
39	FUS_26573619_Chip-Seq_HEK293_Human	1.42215095
40	IGF1R_20145208_ChIP-Seq_DFB_Human	1.41885010
41	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.40132814
42	P300_19829295_ChIP-Seq_ESCs_Human	1.37259628
43	TAF15_26573619_Chip-Seq_HEK293_Human	1.35749962
44	NCOR_22424771_ChIP-Seq_293T_Human	1.35550211
45	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.35446823
46	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.34798351
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34464304
48	EWS_26573619_Chip-Seq_HEK293_Human	1.28808671
49	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.27885566
50	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.25077452
51	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.24466587
52	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.24448522
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24276218
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.22127885
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.21176180
56	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.20752225
57	ER_23166858_ChIP-Seq_MCF-7_Human	1.20286200
58	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.19993333
59	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.19985494
60	MYC_18940864_ChIP-ChIP_HL60_Human	1.19835013
61	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.18485548
62	BCAT_22108803_ChIP-Seq_LS180_Human	1.17566393
63	TAF2_19829295_ChIP-Seq_ESCs_Human	1.14842058
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.13115829
65	CBP_20019798_ChIP-Seq_JUKART_Human	1.12708689
66	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12708689
67	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11236413
68	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10963211
69	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.07927484
70	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07548105
71	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.05035408
72	ERA_21632823_ChIP-Seq_H3396_Human	1.04503217
73	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.04436865
74	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04436865
75	NANOG_20526341_ChIP-Seq_ESCs_Human	1.04143073
76	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.03964939
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03548958
78	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03293744
79	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03293744
80	SMAD4_21799915_ChIP-Seq_A2780_Human	1.00798192
81	AR_25329375_ChIP-Seq_VCAP_Human	0.99534875
82	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.98644060
83	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.97983762
84	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.97301813
85	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.96097630
86	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.95761300
87	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.95567725
88	STAT3_23295773_ChIP-Seq_U87_Human	0.94961450
89	MYC_19829295_ChIP-Seq_ESCs_Human	0.94903897
90	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.94792894
91	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94273094
92	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.93863581
93	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.93757484
94	TCF4_23295773_ChIP-Seq_U87_Human	0.93414348
95	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.92932156
96	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.92889575
97	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.92758764
98	DROSHA_22980978_ChIP-Seq_HELA_Human	0.92296670
99	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.92286672
100	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.91533707

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.77795477
2	MP0003646_muscle_fatigue	3.64292050
3	MP0003787_abnormal_imprinting	3.44759237
4	MP0002837_dystrophic_cardiac_calcinosis	3.32176439
5	MP0005646_abnormal_pituitary_gland	2.95938532
6	MP0009379_abnormal_foot_pigmentation	2.64881570
7	MP0002653_abnormal_ependyma_morphology	2.38842323
8	MP0001485_abnormal_pinna_reflex	2.15207028
9	MP0002163_abnormal_gland_morphology	2.15085468
10	MP0008877_abnormal_DNA_methylation	2.11166648
11	MP0002102_abnormal_ear_morphology	2.02350994
12	MP0006276_abnormal_autonomic_nervous	1.91478738
13	MP0003880_abnormal_central_pattern	1.90397803
14	MP0005551_abnormal_eye_electrophysiolog	1.90397591
15	MP0004130_abnormal_muscle_cell	1.88817755
16	MP0004142_abnormal_muscle_tone	1.88410496
17	MP0003011_delayed_dark_adaptation	1.88025314
18	MP0004885_abnormal_endolymph	1.86441789
19	MP0001968_abnormal_touch/_nociception	1.84091023
20	MP0002160_abnormal_reproductive_system	1.81383084
21	MP0003121_genomic_imprinting	1.80781620
22	MP0003122_maternal_imprinting	1.79643743
23	MP0003123_paternal_imprinting	1.76604190
24	MP0002272_abnormal_nervous_system	1.75016738
25	MP0008789_abnormal_olfactory_epithelium	1.73474356
26	MP0004133_heterotaxia	1.71660721
27	MP0002638_abnormal_pupillary_reflex	1.70754188
28	MP0000631_abnormal_neuroendocrine_gland	1.70085760
29	MP0009745_abnormal_behavioral_response	1.69714772
30	MP0000049_abnormal_middle_ear	1.65696929
31	MP0004145_abnormal_muscle_electrophysio	1.63720896
32	MP0002736_abnormal_nociception_after	1.62508285
33	MP0006072_abnormal_retinal_apoptosis	1.61399858
34	MP0008872_abnormal_physiological_respon	1.54033858
35	MP0003879_abnormal_hair_cell	1.53649358
36	MP0005389_reproductive_system_phenotype	1.49910445
37	MP0002876_abnormal_thyroid_physiology	1.49903646
38	MP0005379_endocrine/exocrine_gland_phen	1.45765792
39	MP0005423_abnormal_somatic_nervous	1.37673284
40	MP0000778_abnormal_nervous_system	1.37181003
41	MP0002733_abnormal_thermal_nociception	1.34971243
42	MP0009046_muscle_twitch	1.34617659
43	MP0003195_calcinosis	1.32007707
44	MP0001905_abnormal_dopamine_level	1.29710695
45	MP0005499_abnormal_olfactory_system	1.29338191
46	MP0005394_taste/olfaction_phenotype	1.29338191
47	MP0001970_abnormal_pain_threshold	1.29026689
48	MP0002557_abnormal_social/conspecific_i	1.24909720
49	MP0003878_abnormal_ear_physiology	1.23276798
50	MP0005377_hearing/vestibular/ear_phenot	1.23276798
51	MP0003635_abnormal_synaptic_transmissio	1.21037778
52	MP0003136_yellow_coat_color	1.21011471
53	MP0005195_abnormal_posterior_eye	1.20360524
54	MP0000026_abnormal_inner_ear	1.19516062
55	MP0002138_abnormal_hepatobiliary_system	1.19052192
56	MP0002063_abnormal_learning/memory/cond	1.17456500
57	MP0005253_abnormal_eye_physiology	1.17279273
58	MP0001986_abnormal_taste_sensitivity	1.15595903
59	MP0001440_abnormal_grooming_behavior	1.15135614
60	MP0001919_abnormal_reproductive_system	1.14885589
61	MP0002572_abnormal_emotion/affect_behav	1.13572303
62	MP0002064_seizures	1.13539603
63	MP0002184_abnormal_innervation	1.12206625
64	MP0002752_abnormal_somatic_nervous	1.12025158
65	MP0004742_abnormal_vestibular_system	1.11940011
66	MP0002734_abnormal_mechanical_nocicepti	1.11615397
67	MP0005645_abnormal_hypothalamus_physiol	1.10204006
68	MP0005670_abnormal_white_adipose	1.09787220
69	MP0008775_abnormal_heart_ventricle	1.09416806
70	MP0008875_abnormal_xenobiotic_pharmacok	1.09261726
71	MP0003938_abnormal_ear_development	1.08130427
72	MP0001529_abnormal_vocalization	1.08127552
73	MP0009053_abnormal_anal_canal	1.07971503
74	MP0001963_abnormal_hearing_physiology	1.07830319
75	MP0000955_abnormal_spinal_cord	1.04096743
76	MP0003119_abnormal_digestive_system	1.03782013
77	MP0001486_abnormal_startle_reflex	1.03498623
78	MP0000230_abnormal_systemic_arterial	1.02770102
79	MP0001188_hyperpigmentation	1.00264089
80	MP0005084_abnormal_gallbladder_morpholo	0.98186544
81	MP0002735_abnormal_chemical_nociception	0.95200274
82	MP0002938_white_spotting	0.93851677
83	MP0002067_abnormal_sensory_capabilities	0.92358984
84	MP0001293_anophthalmia	0.88370262
85	MP0000372_irregular_coat_pigmentation	0.87978314
86	MP0002277_abnormal_respiratory_mucosa	0.87063639
87	MP0002882_abnormal_neuron_morphology	0.87011556
88	MP0002234_abnormal_pharynx_morphology	0.85874056
89	MP0002928_abnormal_bile_duct	0.83229289
90	MP0003942_abnormal_urinary_system	0.81801921
91	MP0002229_neurodegeneration	0.81501149
92	MP0003890_abnormal_embryonic-extraembry	0.78739604
93	MP0005410_abnormal_fertilization	0.78525699
94	MP0004147_increased_porphyrin_level	0.76211441
95	MP0001984_abnormal_olfaction	0.76138552
96	MP0010386_abnormal_urinary_bladder	0.75165854
97	MP0004924_abnormal_behavior	0.74763101
98	MP0005386_behavior/neurological_phenoty	0.74763101
99	MP0000427_abnormal_hair_cycle	0.74638022
100	MP0004043_abnormal_pH_regulation	0.74462251

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Molar tooth sign on MRI (HP:0002419)	3.75772052
2	Abnormality of midbrain morphology (HP:0002418)	3.75772052
3	Congenital stationary night blindness (HP:0007642)	3.74848286
4	Pancreatic cysts (HP:0001737)	3.70548140
5	Pancreatic fibrosis (HP:0100732)	3.68614973
6	True hermaphroditism (HP:0010459)	3.50844093
7	Pendular nystagmus (HP:0012043)	3.48418607
8	Nephronophthisis (HP:0000090)	3.25469678
9	Stenosis of the external auditory canal (HP:0000402)	3.17298203
10	Acute necrotizing encephalopathy (HP:0006965)	3.13802641
11	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.08540636
12	Abolished electroretinogram (ERG) (HP:0000550)	3.03259777
13	Agitation (HP:0000713)	2.94688600
14	Abnormal rod and cone electroretinograms (HP:0008323)	2.93748686
15	Abnormal mitochondria in muscle tissue (HP:0008316)	2.72936706
16	Abnormality of the renal medulla (HP:0100957)	2.72074366
17	Hyperglycinemia (HP:0002154)	2.65949931
18	Progressive macrocephaly (HP:0004481)	2.65807285
19	Abnormality of cells of the erythroid lineage (HP:0012130)	2.64935349
20	Medial flaring of the eyebrow (HP:0010747)	2.62957930
21	Acute encephalopathy (HP:0006846)	2.62047899
22	Septo-optic dysplasia (HP:0100842)	2.61456173
23	Mitochondrial inheritance (HP:0001427)	2.60617852
24	Reticulocytopenia (HP:0001896)	2.50626384
25	Short 1st metacarpal (HP:0010034)	2.49774854
26	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.49774854
27	3-Methylglutaconic aciduria (HP:0003535)	2.49252342
28	Cystic liver disease (HP:0006706)	2.47587263
29	Absent thumb (HP:0009777)	2.47558907
30	Progressive cerebellar ataxia (HP:0002073)	2.45354210
31	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.44437634
32	Abnormality of the renal cortex (HP:0011035)	2.41805256
33	Asplenia (HP:0001746)	2.41566014
34	Tubular atrophy (HP:0000092)	2.40862799
35	Chronic hepatic failure (HP:0100626)	2.39708570
36	Sclerocornea (HP:0000647)	2.35214119
37	Increased CSF lactate (HP:0002490)	2.33558595
38	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.32564239
39	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.31675480
40	Abnormal number of erythroid precursors (HP:0012131)	2.30456892
41	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.29736102
42	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.28859698
43	Anencephaly (HP:0002323)	2.27720069
44	Type II lissencephaly (HP:0007260)	2.23988736
45	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.23492273
46	Decreased central vision (HP:0007663)	2.22872150
47	Abnormality of the nasal septum (HP:0000419)	2.22458195
48	Adrenal hypoplasia (HP:0000835)	2.21634179
49	Chorioretinal atrophy (HP:0000533)	2.21558149
50	Abnormality of the 1st metacarpal (HP:0010009)	2.18852555
51	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.17547178
52	Rib fusion (HP:0000902)	2.16698245
53	Keratoconus (HP:0000563)	2.15741329
54	Increased corneal curvature (HP:0100692)	2.15741329
55	Attenuation of retinal blood vessels (HP:0007843)	2.15688721
56	Abnormality of the renal collecting system (HP:0004742)	2.14887075
57	Abnormality of the middle phalanges of the toes (HP:0010183)	2.14302805
58	Myokymia (HP:0002411)	2.14027537
59	Gait imbalance (HP:0002141)	2.13974723
60	Congenital sensorineural hearing impairment (HP:0008527)	2.12560148
61	Optic nerve hypoplasia (HP:0000609)	2.11019233
62	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.09554915
63	Absent/shortened dynein arms (HP:0200106)	2.09554915
64	Abnormality of alanine metabolism (HP:0010916)	2.06709769
65	Hyperalaninemia (HP:0003348)	2.06709769
66	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.06709769
67	Methylmalonic acidemia (HP:0002912)	2.06412511
68	Optic disc pallor (HP:0000543)	2.06185416
69	Limb dystonia (HP:0002451)	2.04677378
70	Genetic anticipation (HP:0003743)	2.03137434
71	Male pseudohermaphroditism (HP:0000037)	2.00194031
72	Short hallux (HP:0010109)	1.97985138
73	Congenital primary aphakia (HP:0007707)	1.97196443
74	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.97078043
75	Congenital, generalized hypertrichosis (HP:0004540)	1.95908657
76	Polydipsia (HP:0001959)	1.95268253
77	Abnormal drinking behavior (HP:0030082)	1.95268253
78	Maternal diabetes (HP:0009800)	1.94597632
79	Hypoplasia of the ulna (HP:0003022)	1.92290041
80	Abnormal respiratory motile cilium morphology (HP:0005938)	1.90832346
81	Abnormal respiratory epithelium morphology (HP:0012253)	1.90832346
82	Morphological abnormality of the middle ear (HP:0008609)	1.89275169
83	Nephrogenic diabetes insipidus (HP:0009806)	1.89137501
84	Hyperthyroidism (HP:0000836)	1.89081391
85	Bony spicule pigmentary retinopathy (HP:0007737)	1.86931974
86	Methylmalonic aciduria (HP:0012120)	1.86331471
87	Thyroid-stimulating hormone excess (HP:0002925)	1.86161571
88	Neoplasm of the adrenal cortex (HP:0100641)	1.86113231
89	Hepatocellular necrosis (HP:0001404)	1.84721679
90	Concave nail (HP:0001598)	1.81500712
91	Abnormal ciliary motility (HP:0012262)	1.78917545
92	Polyuria (HP:0000103)	1.78218793
93	Lissencephaly (HP:0001339)	1.77965897
94	Anophthalmia (HP:0000528)	1.76289082
95	Pachygyria (HP:0001302)	1.76181645
96	Ectopic kidney (HP:0000086)	1.75864653
97	Abnormal pancreas size (HP:0012094)	1.75727896
98	Short femoral neck (HP:0100864)	1.75372560
99	Cerebral edema (HP:0002181)	1.74620003
100	Hypoplasia of the uterus (HP:0000013)	1.74463321

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.31431463
2	BMPR1B	3.20464695
3	GRK1	3.12875551
4	ADRBK2	3.12848065
5	WNK4	2.73296307
6	WNK3	2.53233581
7	STK16	2.47945670
8	ZAK	2.45885515
9	PINK1	2.43544907
10	TLK1	2.21772714
11	MAP4K2	2.20980011
12	MUSK	2.06890475
13	CASK	1.97574847
14	DYRK2	1.91343242
15	NUAK1	1.74748732
16	TAOK3	1.69661123
17	MAPK13	1.58738158
18	TXK	1.49089298
19	BCKDK	1.47708632
20	MAP3K4	1.44964168
21	TIE1	1.41708444
22	NTRK2	1.41302609
23	NTRK3	1.36517770
24	PRKCG	1.36346711
25	PIK3CA	1.31056729
26	CAMKK2	1.30629041
27	STK39	1.21443074
28	INSRR	1.20163969
29	MARK1	1.17697798
30	MAP2K7	1.16387126
31	ACVR1B	1.11108915
32	ADRBK1	1.10521866
33	OXSR1	1.05480684
34	PAK3	1.05171874
35	PLK2	1.02420769
36	EPHA4	1.01078020
37	CAMKK1	0.96979654
38	MAP3K9	0.96530562
39	TNIK	0.95293190
40	MAP3K11	0.95253635
41	SGK223	0.92921202
42	SGK494	0.92921202
43	CDK19	0.92514576
44	PRKCQ	0.90335582
45	LIMK1	0.88480220
46	PHKG2	0.86807522
47	PHKG1	0.86807522
48	MAPKAPK5	0.82753757
49	TYRO3	0.81815223
50	STK11	0.81292528
51	MINK1	0.80030616
52	EPHB2	0.79092646
53	PASK	0.77728158
54	DAPK2	0.77548211
55	CAMK1	0.76484304
56	CSNK1G2	0.76031370
57	TAF1	0.74429808
58	PRKACA	0.71051435
59	PRKCE	0.69427576
60	PRKCI	0.66804113
61	SGK2	0.65401299
62	MAP2K6	0.63791139
63	PKN1	0.60799611
64	CAMK2A	0.60672707
65	DYRK3	0.59350528
66	AKT3	0.58888377
67	VRK1	0.58125701
68	TEC	0.57533860
69	MAPKAPK3	0.56839112
70	SIK2	0.56751867
71	PRKCZ	0.55871746
72	RPS6KA5	0.55818967
73	PRKCH	0.55612125
74	CSNK1A1	0.54348547
75	GRK7	0.53028017
76	CSNK1G3	0.52584067
77	TNK2	0.51667849
78	PRKCA	0.51540104
79	KIT	0.51024469
80	GRK5	0.50629378
81	RPS6KA6	0.49290712
82	IKBKB	0.49103151
83	CDK5	0.48584689
84	SGK1	0.48513928
85	FGFR2	0.48142479
86	SYK	0.45858150
87	NME1	0.45269305
88	ABL2	0.43498704
89	BRAF	0.42934727
90	AURKA	0.42517327
91	CAMK1D	0.41819296
92	CSNK1G1	0.39596882
93	ERBB2	0.39420195
94	VRK2	0.38805617
95	TGFBR1	0.38776841
96	OBSCN	0.37641867
97	PRKCD	0.36738529
98	MKNK2	0.33547314
99	PRKD2	0.33451371
100	ITK	0.33342154

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.33663854
2	Phototransduction_Homo sapiens_hsa04744	3.23096525
3	Ribosome_Homo sapiens_hsa03010	3.23092438
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.81756329
5	Parkinsons disease_Homo sapiens_hsa05012	2.62184462
6	Nicotine addiction_Homo sapiens_hsa05033	2.29139197
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.22619273
8	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.21751768
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.20799744
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.09457484
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.05373013
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.93013763
13	Alzheimers disease_Homo sapiens_hsa05010	1.84701756
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.81140729
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.74572410
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.72275524
17	Huntingtons disease_Homo sapiens_hsa05016	1.72134054
18	Sulfur metabolism_Homo sapiens_hsa00920	1.66745534
19	Sulfur relay system_Homo sapiens_hsa04122	1.62749017
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.62199236
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.59933822
22	Morphine addiction_Homo sapiens_hsa05032	1.58454194
23	Caffeine metabolism_Homo sapiens_hsa00232	1.56011654
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.49432978
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.47893102
26	Butanoate metabolism_Homo sapiens_hsa00650	1.43956176
27	RNA polymerase_Homo sapiens_hsa03020	1.41961031
28	Olfactory transduction_Homo sapiens_hsa04740	1.33189930
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.29746783
30	Protein export_Homo sapiens_hsa03060	1.26476838
31	Peroxisome_Homo sapiens_hsa04146	1.23041916
32	Selenocompound metabolism_Homo sapiens_hsa00450	1.19467201
33	Collecting duct acid secretion_Homo sapiens_hsa04966	1.19097517
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.18372463
35	Retinol metabolism_Homo sapiens_hsa00830	1.16832094
36	Insulin secretion_Homo sapiens_hsa04911	1.15133296
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.14966211
38	GABAergic synapse_Homo sapiens_hsa04727	1.11920964
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.06880725
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.06262071
41	Glutamatergic synapse_Homo sapiens_hsa04724	1.06113778
42	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.06100251
43	Serotonergic synapse_Homo sapiens_hsa04726	1.05858142
44	Fat digestion and absorption_Homo sapiens_hsa04975	1.05426537
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.04800285
46	Homologous recombination_Homo sapiens_hsa03440	1.04473008
47	RNA degradation_Homo sapiens_hsa03018	1.04325817
48	Glycerolipid metabolism_Homo sapiens_hsa00561	1.01958423
49	Basal cell carcinoma_Homo sapiens_hsa05217	0.99598415
50	Circadian entrainment_Homo sapiens_hsa04713	0.98784427
51	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.98458703
52	Taste transduction_Homo sapiens_hsa04742	0.97179143
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.94305809
54	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.92988386
55	Fanconi anemia pathway_Homo sapiens_hsa03460	0.92435732
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.88600374
57	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.79028165
58	Dopaminergic synapse_Homo sapiens_hsa04728	0.77902092
59	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.73865036
60	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.72807963
61	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.71708501
62	Steroid biosynthesis_Homo sapiens_hsa00100	0.71487574
63	Basal transcription factors_Homo sapiens_hsa03022	0.71400030
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70932478
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70548490
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70255223
67	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.69706313
68	Axon guidance_Homo sapiens_hsa04360	0.67950302
69	Cocaine addiction_Homo sapiens_hsa05030	0.67171207
70	Regulation of autophagy_Homo sapiens_hsa04140	0.66506985
71	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.66292085
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65981217
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65432462
74	Metabolic pathways_Homo sapiens_hsa01100	0.64028797
75	Primary immunodeficiency_Homo sapiens_hsa05340	0.62791889
76	Cholinergic synapse_Homo sapiens_hsa04725	0.61112040
77	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.60910539
78	One carbon pool by folate_Homo sapiens_hsa00670	0.60136730
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.59993660
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.57576166
81	Pyrimidine metabolism_Homo sapiens_hsa00240	0.56566607
82	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.54226777
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53937619
84	Purine metabolism_Homo sapiens_hsa00230	0.51019871
85	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.49239406
86	Propanoate metabolism_Homo sapiens_hsa00640	0.45741103
87	Salivary secretion_Homo sapiens_hsa04970	0.45298029
88	Amphetamine addiction_Homo sapiens_hsa05031	0.41185805
89	Asthma_Homo sapiens_hsa05310	0.39901889
90	Long-term depression_Homo sapiens_hsa04730	0.39886607
91	Fatty acid degradation_Homo sapiens_hsa00071	0.39215218
92	cAMP signaling pathway_Homo sapiens_hsa04024	0.37777633
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.36122100
94	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.35591412
95	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.33706954
96	Type II diabetes mellitus_Homo sapiens_hsa04930	0.33188349
97	ABC transporters_Homo sapiens_hsa02010	0.32881371
98	Tyrosine metabolism_Homo sapiens_hsa00350	0.30389005
99	Histidine metabolism_Homo sapiens_hsa00340	0.30317810
100	Mineral absorption_Homo sapiens_hsa04978	0.29016722

HNRNPA1P40

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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