ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.56886232
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.68249551
3	ATP synthesis coupled proton transport (GO:0015986)	4.53823741
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.53823741
5	proteasome assembly (GO:0043248)	4.33260257
6	protein neddylation (GO:0045116)	3.96825941
7	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.89255431
8	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.81915076
9	cytidine deamination (GO:0009972)	3.80892040
10	cytidine metabolic process (GO:0046087)	3.80892040
11	cytidine catabolic process (GO:0006216)	3.80892040
12	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.80093942
13	rRNA modification (GO:0000154)	3.71658755
14	kynurenine metabolic process (GO:0070189)	3.56364616
15	ribosomal small subunit assembly (GO:0000028)	3.55606275
16	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.53186187
17	electron transport chain (GO:0022900)	3.51588730
18	respiratory electron transport chain (GO:0022904)	3.50953081
19	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.49801336
20	respiratory chain complex IV assembly (GO:0008535)	3.41937659
21	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.41648154
22	behavioral response to nicotine (GO:0035095)	3.38765909
23	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.32179129
24	regulation of chronic inflammatory response (GO:0002676)	3.31960601
25	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.28208363
26	termination of RNA polymerase III transcription (GO:0006386)	3.28208363
27	protein complex biogenesis (GO:0070271)	3.27290738
28	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.25891012
29	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.25891012
30	maturation of 5.8S rRNA (GO:0000460)	3.25553583
31	regulation of cellular amino acid metabolic process (GO:0006521)	3.19143468
32	tryptophan catabolic process (GO:0006569)	3.17708588
33	indole-containing compound catabolic process (GO:0042436)	3.17708588
34	indolalkylamine catabolic process (GO:0046218)	3.17708588
35	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.17311007
36	cytochrome complex assembly (GO:0017004)	3.12031662
37	tryptophan metabolic process (GO:0006568)	3.11045470
38	water-soluble vitamin biosynthetic process (GO:0042364)	3.10468583
39	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.07490112
40	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.00109620
41	indolalkylamine metabolic process (GO:0006586)	2.98519102
42	rRNA catabolic process (GO:0016075)	2.95344839
43	histone mRNA metabolic process (GO:0008334)	2.95309531
44	mitochondrial respiratory chain complex assembly (GO:0033108)	2.94225205
45	negative regulation of heart rate (GO:0010459)	2.94010951
46	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.93160029
47	regulation of mitotic spindle checkpoint (GO:1903504)	2.93160029
48	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.91690861
49	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.89033568
50	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.89033568
51	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.89033568
52	rRNA methylation (GO:0031167)	2.87293463
53	pseudouridine synthesis (GO:0001522)	2.86479634
54	mannosylation (GO:0097502)	2.86465431
55	base-excision repair, AP site formation (GO:0006285)	2.85194727
56	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.83281637
57	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.83281637
58	NADH dehydrogenase complex assembly (GO:0010257)	2.83281637
59	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.83265880
60	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.81777935
61	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.81777935
62	chaperone-mediated protein transport (GO:0072321)	2.79610786
63	platelet dense granule organization (GO:0060155)	2.78044100
64	negative regulation of mast cell activation (GO:0033004)	2.75858908
65	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.74957589
66	hydrogen ion transmembrane transport (GO:1902600)	2.72920947
67	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.71524606
68	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.70122686
69	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.70122686
70	tRNA processing (GO:0008033)	2.69841743
71	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.69618389
72	negative regulation of ligase activity (GO:0051352)	2.69618389
73	proton transport (GO:0015992)	2.68881327
74	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.67719711
75	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.67719711
76	mismatch repair (GO:0006298)	2.66488106
77	aldehyde catabolic process (GO:0046185)	2.66024451
78	hydrogen transport (GO:0006818)	2.64579229
79	L-fucose catabolic process (GO:0042355)	2.62408913
80	fucose catabolic process (GO:0019317)	2.62408913
81	L-fucose metabolic process (GO:0042354)	2.62408913
82	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.60111870
83	protein-cofactor linkage (GO:0018065)	2.59773841
84	cellular ketone body metabolic process (GO:0046950)	2.55932380
85	preassembly of GPI anchor in ER membrane (GO:0016254)	2.55145498
86	ATP biosynthetic process (GO:0006754)	2.52979136
87	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.51816738
88	ribosomal large subunit biogenesis (GO:0042273)	2.51736793
89	DNA double-strand break processing (GO:0000729)	2.50623959
90	cullin deneddylation (GO:0010388)	2.48686309
91	oxidative phosphorylation (GO:0006119)	2.46462115
92	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.45419981
93	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.44694437
94	protein deneddylation (GO:0000338)	2.42383943
95	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.41406593
96	rRNA processing (GO:0006364)	2.41090752
97	rRNA metabolic process (GO:0016072)	2.40520661
98	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.40090748
99	replication fork processing (GO:0031297)	2.37974650
100	positive regulation of defense response to virus by host (GO:0002230)	2.36554843

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.87579612
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.78721604
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.41139219
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.04391423
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.99497870
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.98218833
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.92318563
8	VDR_22108803_ChIP-Seq_LS180_Human	2.64247760
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.53831020
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.42191338
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.40409474
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.38226109
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.37296706
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.36862245
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.28666212
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.28078813
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.20824162
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.12295789
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.09618435
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.07095160
21	EWS_26573619_Chip-Seq_HEK293_Human	2.05897214
22	FOXP3_21729870_ChIP-Seq_TREG_Human	2.01508428
23	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.97534276
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.86817464
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.82950645
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.82410537
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.81036376
28	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.79387253
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.73666946
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.69872834
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66344420
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65417761
33	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.64754695
34	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.64052503
35	FUS_26573619_Chip-Seq_HEK293_Human	1.63997020
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.57452088
37	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.54864167
38	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.53215557
39	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.53088376
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.50432281
41	P300_19829295_ChIP-Seq_ESCs_Human	1.49567521
42	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.49192336
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.40830209
44	AR_20517297_ChIP-Seq_VCAP_Human	1.39833686
45	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.35934634
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35437295
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35437295
48	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34423678
49	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.34019619
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33984365
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33984365
52	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.33607014
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.32419224
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.31897226
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.31897226
56	HTT_18923047_ChIP-ChIP_STHdh_Human	1.30432654
57	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.29100865
58	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.28999832
59	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.27640254
60	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.27005559
61	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.26092267
62	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.24883854
63	GATA3_26560356_Chip-Seq_TH2_Human	1.24702303
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22892735
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22249961
66	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.20714793
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.19298225
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17459686
69	DCP1A_22483619_ChIP-Seq_HELA_Human	1.15163733
70	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14927914
71	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13060441
72	GBX2_23144817_ChIP-Seq_PC3_Human	1.11567566
73	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.11552383
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09766434
75	MYB_26560356_Chip-Seq_TH2_Human	1.08646687
76	ERG_20517297_ChIP-Seq_VCAP_Human	1.06656373
77	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.06275886
78	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.04310613
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04286341
80	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.03804431
81	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01600671
82	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00486096
83	TCF4_22108803_ChIP-Seq_LS180_Human	0.99749950
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98954183
85	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98417779
86	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.98032213
87	TTF2_22483619_ChIP-Seq_HELA_Human	0.97467476
88	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.97048253
89	NCOR_22424771_ChIP-Seq_293T_Human	0.96757236
90	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.95165875
91	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.94866642
92	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.93829834
93	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.93097335
94	BCAT_22108803_ChIP-Seq_LS180_Human	0.92481190
95	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91664356
96	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.90524554
97	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.90402899
98	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.88158078
99	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.86149203
100	TAF2_19829295_ChIP-Seq_ESCs_Human	0.86008811

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	2.98507321
2	MP0008877_abnormal_DNA_methylation	2.83573223
3	MP0006072_abnormal_retinal_apoptosis	2.73930907
4	MP0001835_abnormal_antigen_presentation	2.69210720
5	MP0005646_abnormal_pituitary_gland	2.52041776
6	MP0006292_abnormal_olfactory_placode	2.50991823
7	MP0008875_abnormal_xenobiotic_pharmacok	2.45642755
8	MP0002102_abnormal_ear_morphology	2.28357958
9	MP0008872_abnormal_physiological_respon	2.20358410
10	MP0005084_abnormal_gallbladder_morpholo	2.15512728
11	MP0000372_irregular_coat_pigmentation	2.14633315
12	MP0002638_abnormal_pupillary_reflex	2.05158028
13	MP0003786_premature_aging	2.00018850
14	MP0004147_increased_porphyrin_level	1.97326458
15	MP0008995_early_reproductive_senescence	1.88737101
16	MP0008058_abnormal_DNA_repair	1.87060417
17	MP0009785_altered_susceptibility_to	1.85824381
18	MP0003195_calcinosis	1.83914083
19	MP0005253_abnormal_eye_physiology	1.79469652
20	MP0005645_abnormal_hypothalamus_physiol	1.79262809
21	MP0005551_abnormal_eye_electrophysiolog	1.77930732
22	MP0004145_abnormal_muscle_electrophysio	1.70449988
23	MP0001919_abnormal_reproductive_system	1.68232605
24	MP0002736_abnormal_nociception_after	1.62914240
25	MP0003011_delayed_dark_adaptation	1.61841492
26	MP0001873_stomach_inflammation	1.61091712
27	MP0002166_altered_tumor_susceptibility	1.59685278
28	MP0002148_abnormal_hypersensitivity_rea	1.58001757
29	MP0003787_abnormal_imprinting	1.53698562
30	MP0002139_abnormal_hepatobiliary_system	1.47045826
31	MP0001800_abnormal_humoral_immune	1.45825073
32	MP0003718_maternal_effect	1.44479217
33	MP0002006_tumorigenesis	1.43803261
34	MP0009697_abnormal_copulation	1.41157892
35	MP0004142_abnormal_muscle_tone	1.40118379
36	MP0001968_abnormal_touch/_nociception	1.39613774
37	MP0001764_abnormal_homeostasis	1.39414317
38	MP0005389_reproductive_system_phenotype	1.36760636
39	MP0005085_abnormal_gallbladder_physiolo	1.36588725
40	MP0002751_abnormal_autonomic_nervous	1.31184117
41	MP0002837_dystrophic_cardiac_calcinosis	1.30081794
42	MP0009764_decreased_sensitivity_to	1.24489416
43	MP0001501_abnormal_sleep_pattern	1.22941989
44	MP0006036_abnormal_mitochondrial_physio	1.21952454
45	MP0004885_abnormal_endolymph	1.21829626
46	MP0005000_abnormal_immune_tolerance	1.20261903
47	MP0002234_abnormal_pharynx_morphology	1.20213327
48	MP0003806_abnormal_nucleotide_metabolis	1.16125191
49	MP0004215_abnormal_myocardial_fiber	1.15930022
50	MP0002876_abnormal_thyroid_physiology	1.14953457
51	MP0003646_muscle_fatigue	1.13247761
52	MP0006276_abnormal_autonomic_nervous	1.12012607
53	MP0002277_abnormal_respiratory_mucosa	1.11735543
54	MP0003693_abnormal_embryo_hatching	1.10853395
55	MP0003186_abnormal_redox_activity	1.09426882
56	MP0005332_abnormal_amino_acid	1.04888043
57	MP0002160_abnormal_reproductive_system	1.04401728
58	MP0002723_abnormal_immune_serum	1.04336996
59	MP0001905_abnormal_dopamine_level	1.03944142
60	MP0005636_abnormal_mineral_homeostasis	1.02855573
61	MP0004043_abnormal_pH_regulation	1.00537591
62	MP0000631_abnormal_neuroendocrine_gland	0.99898147
63	MP0002272_abnormal_nervous_system	0.96438933
64	MP0009745_abnormal_behavioral_response	0.95975757
65	MP0003880_abnormal_central_pattern	0.95304236
66	MP0001502_abnormal_circadian_rhythm	0.94842553
67	MP0002733_abnormal_thermal_nociception	0.94377472
68	MP0001970_abnormal_pain_threshold	0.92953127
69	MP0002452_abnormal_antigen_presenting	0.92521759
70	MP0003137_abnormal_impulse_conducting	0.92481606
71	MP0003567_abnormal_fetal_cardiomyocyte	0.91843053
72	MP0002693_abnormal_pancreas_physiology	0.90866773
73	MP0009333_abnormal_splenocyte_physiolog	0.89990819
74	MP0001819_abnormal_immune_cell	0.88635080
75	MP0002420_abnormal_adaptive_immunity	0.88504402
76	MP0003045_fibrosis	0.87707209
77	MP0002138_abnormal_hepatobiliary_system	0.85341148
78	MP0010155_abnormal_intestine_physiology	0.84500341
79	MP0008007_abnormal_cellular_replicative	0.84437342
80	MP0010094_abnormal_chromosome_stability	0.83274260
81	MP0001293_anophthalmia	0.82766403
82	MP0005075_abnormal_melanosome_morpholog	0.82389361
83	MP0002938_white_spotting	0.81967724
84	MP0009046_muscle_twitch	0.81758201
85	MP0001765_abnormal_ion_homeostasis	0.79802747
86	MP0000427_abnormal_hair_cycle	0.76028185
87	MP0001929_abnormal_gametogenesis	0.75813071
88	MP0008789_abnormal_olfactory_epithelium	0.75554577
89	MP0003724_increased_susceptibility_to	0.74649715
90	MP0001845_abnormal_inflammatory_respons	0.73905725
91	MP0003866_abnormal_defecation	0.71777512
92	MP0000383_abnormal_hair_follicle	0.69271706
93	MP0004133_heterotaxia	0.69151731
94	MP0008775_abnormal_heart_ventricle	0.68890174
95	MP0005310_abnormal_salivary_gland	0.68285326
96	MP0002398_abnormal_bone_marrow	0.68243927
97	MP0000716_abnormal_immune_system	0.68214175
98	MP0004957_abnormal_blastocyst_morpholog	0.68114264
99	MP0008961_abnormal_basal_metabolism	0.67105460
100	MP0002090_abnormal_vision	0.66503161

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.03542852
2	Hypoproteinemia (HP:0003075)	3.76152992
3	Mitochondrial inheritance (HP:0001427)	3.61083466
4	Progressive macrocephaly (HP:0004481)	3.53236726
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.50708070
6	Methylmalonic acidemia (HP:0002912)	3.45470755
7	Acute encephalopathy (HP:0006846)	3.34845621
8	Increased CSF lactate (HP:0002490)	3.24428767
9	Increased hepatocellular lipid droplets (HP:0006565)	3.21322144
10	Stomach cancer (HP:0012126)	3.20245805
11	Pancreatic cysts (HP:0001737)	3.13498215
12	IgG deficiency (HP:0004315)	3.10463017
13	Hepatocellular necrosis (HP:0001404)	3.01068457
14	3-Methylglutaconic aciduria (HP:0003535)	2.97014184
15	Pancreatic fibrosis (HP:0100732)	2.96046573
16	Lipid accumulation in hepatocytes (HP:0006561)	2.90005383
17	Congenital stationary night blindness (HP:0007642)	2.88179101
18	Hepatic necrosis (HP:0002605)	2.85437137
19	Aplastic anemia (HP:0001915)	2.84224581
20	Methylmalonic aciduria (HP:0012120)	2.81293422
21	True hermaphroditism (HP:0010459)	2.77771865
22	Cerebral edema (HP:0002181)	2.76264739
23	Colon cancer (HP:0003003)	2.68127028
24	Molar tooth sign on MRI (HP:0002419)	2.67442583
25	Abnormality of midbrain morphology (HP:0002418)	2.67442583
26	Attenuation of retinal blood vessels (HP:0007843)	2.65798944
27	Abolished electroretinogram (ERG) (HP:0000550)	2.59603448
28	Abnormality of alanine metabolism (HP:0010916)	2.58892804
29	Hyperalaninemia (HP:0003348)	2.58892804
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.58892804
31	Pendular nystagmus (HP:0012043)	2.57364656
32	Renal Fanconi syndrome (HP:0001994)	2.56304243
33	Decreased central vision (HP:0007663)	2.54712447
34	Type I transferrin isoform profile (HP:0003642)	2.54461217
35	Abnormality of the renal cortex (HP:0011035)	2.54069407
36	Optic disc pallor (HP:0000543)	2.49366375
37	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.46152194
38	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.46151859
39	Stomatitis (HP:0010280)	2.45046894
40	Aplasia/hypoplasia of the uterus (HP:0008684)	2.44748819
41	Abnormality of the prostate (HP:0008775)	2.44390016
42	Congenital, generalized hypertrichosis (HP:0004540)	2.43496379
43	Abnormality of B cell number (HP:0010975)	2.42549766
44	Renal cortical cysts (HP:0000803)	2.39102253
45	Increased corneal curvature (HP:0100692)	2.30880072
46	Keratoconus (HP:0000563)	2.30880072
47	Hypoplasia of the uterus (HP:0000013)	2.29461873
48	Increased intramyocellular lipid droplets (HP:0012240)	2.27524543
49	Testicular atrophy (HP:0000029)	2.26860126
50	Nephronophthisis (HP:0000090)	2.26510091
51	Increased serum lactate (HP:0002151)	2.24878810
52	Reduced antithrombin III activity (HP:0001976)	2.22882667
53	Lactic acidosis (HP:0003128)	2.19775792
54	Abnormality of vitamin B metabolism (HP:0004340)	2.18722502
55	Abnormality of T cell number (HP:0011839)	2.17637368
56	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.17013983
57	Severe combined immunodeficiency (HP:0004430)	2.16863701
58	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.15705375
59	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.15705375
60	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.15077715
61	Thyroiditis (HP:0100646)	2.14701746
62	Type 2 muscle fiber atrophy (HP:0003554)	2.13115415
63	Exertional dyspnea (HP:0002875)	2.11344521
64	Abnormality of serum amino acid levels (HP:0003112)	2.09169223
65	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.08256422
66	Hypoplasia of the pons (HP:0012110)	2.07879324
67	Oral leukoplakia (HP:0002745)	2.07834781
68	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.07488141
69	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.06498563
70	Abnormal protein N-linked glycosylation (HP:0012347)	2.06498563
71	Abnormal protein glycosylation (HP:0012346)	2.06498563
72	Abnormal glycosylation (HP:0012345)	2.06498563
73	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.05716359
74	Dicarboxylic aciduria (HP:0003215)	2.05716359
75	Abnormality of the pons (HP:0007361)	2.05419048
76	Lethargy (HP:0001254)	2.04269423
77	Abnormal rod and cone electroretinograms (HP:0008323)	2.04122890
78	Constricted visual fields (HP:0001133)	2.01788689
79	Respiratory failure (HP:0002878)	2.01328118
80	Hyperglycinemia (HP:0002154)	2.01266649
81	Abnormality of the renal medulla (HP:0100957)	1.99049107
82	T lymphocytopenia (HP:0005403)	1.95831688
83	Panhypogammaglobulinemia (HP:0003139)	1.91571441
84	Autoimmune hemolytic anemia (HP:0001890)	1.90326119
85	Sclerocornea (HP:0000647)	1.88545529
86	Abnormality of eosinophils (HP:0001879)	1.86986527
87	Leukodystrophy (HP:0002415)	1.85822970
88	Increased IgM level (HP:0003496)	1.84578014
89	Meckel diverticulum (HP:0002245)	1.80940213
90	Pancytopenia (HP:0001876)	1.78208332
91	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.77990550
92	Delayed CNS myelination (HP:0002188)	1.77669099
93	Short tibia (HP:0005736)	1.77379191
94	Elevated erythrocyte sedimentation rate (HP:0003565)	1.76803865
95	Abnormality of the ileum (HP:0001549)	1.76237873
96	Autoimmune thrombocytopenia (HP:0001973)	1.75021403
97	Increased muscle lipid content (HP:0009058)	1.74669341
98	Abnormality of renal resorption (HP:0011038)	1.73040871
99	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.72691909
100	Fibular aplasia (HP:0002990)	1.72473233

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.68371457
2	ZAK	3.59277316
3	TLK1	3.10214503
4	TXK	2.75588726
5	VRK2	2.74943129
6	CDK19	2.63981429
7	NUAK1	2.57121557
8	EIF2AK3	2.41778004
9	ADRBK2	2.37838679
10	FRK	2.30493240
11	GRK1	2.29538012
12	BCKDK	2.12749359
13	MST4	2.02718272
14	SRPK1	2.01229600
15	PINK1	1.97143781
16	PBK	1.93413579
17	VRK1	1.83034915
18	BUB1	1.79690164
19	OXSR1	1.73954947
20	NME1	1.72866424
21	MKNK1	1.69889649
22	TAOK3	1.69506180
23	STK16	1.68412373
24	WNK3	1.63182307
25	BMPR1B	1.44750749
26	TEC	1.37285133
27	ITK	1.34849001
28	TRIM28	1.33198488
29	PASK	1.28971279
30	WNK4	1.27582418
31	IKBKE	1.18318148
32	PLK3	1.14815533
33	KDR	1.12898613
34	CAMKK2	1.12276644
35	NEK1	1.11285830
36	ERBB3	1.08970261
37	DYRK2	1.06045056
38	MATK	1.06011409
39	IKBKB	1.00678142
40	TNIK	0.99620702
41	BMPR2	0.97615239
42	TSSK6	0.93499734
43	INSRR	0.92207580
44	FLT3	0.91501999
45	PLK2	0.91399250
46	KIT	0.91352106
47	MAP3K12	0.90654002
48	TIE1	0.88762794
49	TAF1	0.87973402
50	STK39	0.87031719
51	EIF2AK2	0.86101017
52	RPS6KA5	0.83662739
53	MAPK13	0.79115823
54	PIK3CG	0.75674671
55	MKNK2	0.68746461
56	GRK6	0.68287492
57	EIF2AK1	0.68090919
58	SYK	0.66759012
59	CSNK1G1	0.64920132
60	CSNK1G3	0.63657751
61	CSF1R	0.59881364
62	PRKCE	0.58897421
63	PLK4	0.57308202
64	PHKG2	0.57040414
65	PHKG1	0.57040414
66	BTK	0.56596883
67	PRKCQ	0.56588843
68	BCR	0.56274521
69	LCK	0.53733808
70	EPHA3	0.53320195
71	FES	0.50826671
72	CSNK1G2	0.50137793
73	PLK1	0.49730423
74	ATR	0.49545796
75	CSNK1A1	0.47831244
76	MAP4K1	0.47789253
77	NEK9	0.46663900
78	IGF1R	0.44457474
79	LYN	0.44206429
80	IRAK4	0.43233229
81	CSNK1A1L	0.42576169
82	WEE1	0.41936501
83	TBK1	0.41500961
84	RPS6KA4	0.40409541
85	PIM1	0.40407253
86	MYLK	0.40386777
87	AURKB	0.39578760
88	STK4	0.39191779
89	OBSCN	0.38920133
90	CSNK2A1	0.38858470
91	MAP3K4	0.38617417
92	CDC7	0.37054253
93	GRK5	0.36854141
94	TNK2	0.35157207
95	PIK3CA	0.35076233
96	TESK2	0.34206184
97	CHUK	0.34203570
98	MAPKAPK5	0.34051814
99	PRKACA	0.34019605
100	GRK7	0.33660721

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.78687199
2	Proteasome_Homo sapiens_hsa03050	3.65362802
3	Allograft rejection_Homo sapiens_hsa05330	3.19892808
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.10442848
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.08095392
6	Protein export_Homo sapiens_hsa03060	2.99682415
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.68917245
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.65003070
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.59655458
10	Parkinsons disease_Homo sapiens_hsa05012	2.49670143
11	Ribosome_Homo sapiens_hsa03010	2.24897033
12	RNA polymerase_Homo sapiens_hsa03020	2.16668679
13	Caffeine metabolism_Homo sapiens_hsa00232	2.01931917
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.99357695
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.90574188
16	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.66336188
17	RNA degradation_Homo sapiens_hsa03018	1.64522585
18	Antigen processing and presentation_Homo sapiens_hsa04612	1.63820756
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.62273118
20	Propanoate metabolism_Homo sapiens_hsa00640	1.54293053
21	Phototransduction_Homo sapiens_hsa04744	1.53812213
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.52968428
23	Homologous recombination_Homo sapiens_hsa03440	1.51219838
24	Alzheimers disease_Homo sapiens_hsa05010	1.46416609
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.45095008
26	Huntingtons disease_Homo sapiens_hsa05016	1.43237830
27	One carbon pool by folate_Homo sapiens_hsa00670	1.42704591
28	Spliceosome_Homo sapiens_hsa03040	1.37679846
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.36344401
30	Rheumatoid arthritis_Homo sapiens_hsa05323	1.33662932
31	Basal transcription factors_Homo sapiens_hsa03022	1.33397400
32	Butanoate metabolism_Homo sapiens_hsa00650	1.32156728
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24963318
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.24934869
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.22029095
36	Mismatch repair_Homo sapiens_hsa03430	1.20841252
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.19304399
38	Linoleic acid metabolism_Homo sapiens_hsa00591	1.16036994
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.12698274
40	RNA transport_Homo sapiens_hsa03013	1.09081070
41	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.05607441
42	Tryptophan metabolism_Homo sapiens_hsa00380	0.99936854
43	Nucleotide excision repair_Homo sapiens_hsa03420	0.96634343
44	Purine metabolism_Homo sapiens_hsa00230	0.94967452
45	Pyrimidine metabolism_Homo sapiens_hsa00240	0.94470036
46	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.91576012
47	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.91423380
48	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.87942120
49	Base excision repair_Homo sapiens_hsa03410	0.86640651
50	Peroxisome_Homo sapiens_hsa04146	0.84591054
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83240160
52	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.79963217
53	Viral myocarditis_Homo sapiens_hsa05416	0.79901575
54	Olfactory transduction_Homo sapiens_hsa04740	0.79559043
55	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.75964445
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73436602
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.72556571
58	Retinol metabolism_Homo sapiens_hsa00830	0.69950101
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.67781696
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62981175
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62142299
62	Leishmaniasis_Homo sapiens_hsa05140	0.60157898
63	Non-homologous end-joining_Homo sapiens_hsa03450	0.59556963
64	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.58659887
65	Fatty acid elongation_Homo sapiens_hsa00062	0.57937264
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.56170399
67	Selenocompound metabolism_Homo sapiens_hsa00450	0.55718734
68	Metabolic pathways_Homo sapiens_hsa01100	0.55234955
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53115973
70	Taste transduction_Homo sapiens_hsa04742	0.52652055
71	DNA replication_Homo sapiens_hsa03030	0.52008240
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51798524
73	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.51693203
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.51569306
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51170540
76	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.50313956
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49748110
78	Herpes simplex infection_Homo sapiens_hsa05168	0.49712110
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48287465
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48164555
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46824920
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45400584
83	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.39155047
84	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.39102077
85	Nicotine addiction_Homo sapiens_hsa05033	0.38725676
86	Salivary secretion_Homo sapiens_hsa04970	0.38055542
87	Glutathione metabolism_Homo sapiens_hsa00480	0.37693359
88	ABC transporters_Homo sapiens_hsa02010	0.37141033
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36350277
90	Sulfur metabolism_Homo sapiens_hsa00920	0.35853158
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.35122320
92	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.34282334
93	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.33320767
94	Pyruvate metabolism_Homo sapiens_hsa00620	0.32872372
95	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.30920732
96	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.30809677
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.30321956
98	Regulation of autophagy_Homo sapiens_hsa04140	0.29319450
99	Morphine addiction_Homo sapiens_hsa05032	0.28713474
100	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.28663192

HNRNPA1P42

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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