HNRNPA1P44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.41010820
2establishment of protein localization to mitochondrial membrane (GO:0090151)5.32120705
3mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.02762681
4mitochondrial respiratory chain complex I assembly (GO:0032981)5.02762681
5NADH dehydrogenase complex assembly (GO:0010257)5.02762681
6chaperone-mediated protein transport (GO:0072321)4.83155664
7protein complex biogenesis (GO:0070271)4.35455784
8mitochondrial respiratory chain complex assembly (GO:0033108)4.29951976
9RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.27269021
10tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.27269021
11protein deneddylation (GO:0000338)4.06060252
12ATP synthesis coupled proton transport (GO:0015986)4.05993721
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.05993721
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.90298857
15fucose catabolic process (GO:0019317)3.84170750
16L-fucose metabolic process (GO:0042354)3.84170750
17L-fucose catabolic process (GO:0042355)3.84170750
18negative regulation of mast cell activation (GO:0033004)3.69836131
19nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.69602283
20cullin deneddylation (GO:0010388)3.68538915
21water-soluble vitamin biosynthetic process (GO:0042364)3.65529217
22exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.60108202
23platelet dense granule organization (GO:0060155)3.38875562
24pseudouridine synthesis (GO:0001522)3.38471703
25maturation of 5.8S rRNA (GO:0000460)3.30994600
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.29629683
27protein neddylation (GO:0045116)3.28812232
28transcription elongation from RNA polymerase I promoter (GO:0006362)3.24643844
29negative regulation of telomere maintenance (GO:0032205)3.23594696
30respiratory chain complex IV assembly (GO:0008535)3.22778088
31proteasome assembly (GO:0043248)3.17370570
32somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.16821157
33isotype switching (GO:0045190)3.16821157
34somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.16821157
35somatic diversification of immunoglobulins (GO:0016445)3.13143596
36maturation of SSU-rRNA (GO:0030490)3.10176385
37positive regulation of oligodendrocyte differentiation (GO:0048714)3.08430429
38RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.05920627
39ubiquinone metabolic process (GO:0006743)3.02730761
40termination of RNA polymerase I transcription (GO:0006363)3.00071625
41somatic diversification of immune receptors via somatic mutation (GO:0002566)2.99004486
42somatic hypermutation of immunoglobulin genes (GO:0016446)2.99004486
43DNA damage response, detection of DNA damage (GO:0042769)2.98195119
44protein-cofactor linkage (GO:0018065)2.98141775
45somatic recombination of immunoglobulin gene segments (GO:0016447)2.96733259
46termination of RNA polymerase III transcription (GO:0006386)2.94975963
47transcription elongation from RNA polymerase III promoter (GO:0006385)2.94975963
48GTP biosynthetic process (GO:0006183)2.94911752
49tRNA processing (GO:0008033)2.93062979
50preassembly of GPI anchor in ER membrane (GO:0016254)2.91173505
51ubiquinone biosynthetic process (GO:0006744)2.85228225
52somite development (GO:0061053)2.81788461
53regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.81575940
54regulation of mitotic spindle checkpoint (GO:1903504)2.81575940
55rRNA metabolic process (GO:0016072)2.80770712
56rRNA processing (GO:0006364)2.79619264
57electron transport chain (GO:0022900)2.78198496
58folic acid-containing compound biosynthetic process (GO:0009396)2.77645220
59respiratory electron transport chain (GO:0022904)2.76519687
60inner mitochondrial membrane organization (GO:0007007)2.70465474
61response to pheromone (GO:0019236)2.70215613
62intracellular protein transmembrane import (GO:0044743)2.69655257
63protein localization to mitochondrion (GO:0070585)2.69646743
64aggressive behavior (GO:0002118)2.65836421
65protein targeting to mitochondrion (GO:0006626)2.64553387
66gamma-aminobutyric acid transport (GO:0015812)2.63792291
67ribosomal small subunit assembly (GO:0000028)2.63221122
68mannosylation (GO:0097502)2.62757509
69rRNA modification (GO:0000154)2.62653626
70tRNA metabolic process (GO:0006399)2.60929860
71establishment of protein localization to mitochondrion (GO:0072655)2.60729195
72telomere maintenance via telomerase (GO:0007004)2.58146329
73somatic diversification of immune receptors (GO:0002200)2.56717258
74DNA catabolic process, exonucleolytic (GO:0000738)2.55227182
75UTP biosynthetic process (GO:0006228)2.54858426
76regulation of timing of cell differentiation (GO:0048505)2.54069986
77ncRNA processing (GO:0034470)2.51869538
78rRNA catabolic process (GO:0016075)2.51714689
79ncRNA metabolic process (GO:0034660)2.51018554
80cellular component biogenesis (GO:0044085)2.50923839
81opioid receptor signaling pathway (GO:0038003)2.49381501
82positive regulation of mitochondrial fission (GO:0090141)2.49015357
83kynurenine metabolic process (GO:0070189)2.48803719
84spliceosomal snRNP assembly (GO:0000387)2.48033745
85purine nucleoside triphosphate biosynthetic process (GO:0009145)2.47956159
86transcription from RNA polymerase I promoter (GO:0006360)2.47620375
87purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.47506402
88UTP metabolic process (GO:0046051)2.47388701
89regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.45859955
90behavioral response to nicotine (GO:0035095)2.44676073
91negative regulation of DNA-dependent DNA replication (GO:2000104)2.42461996
92replication fork processing (GO:0031297)2.41222276
93somatic cell DNA recombination (GO:0016444)2.40150084
94somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.40150084
95cardiac left ventricle morphogenesis (GO:0003214)2.39772394
96indole-containing compound catabolic process (GO:0042436)2.39691447
97indolalkylamine catabolic process (GO:0046218)2.39691447
98tryptophan catabolic process (GO:0006569)2.39691447
99regulation of germinal center formation (GO:0002634)2.39523496
100DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.38630150

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.64504652
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.12016892
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.00665230
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.32492960
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.09511813
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.08507697
7ZNF274_21170338_ChIP-Seq_K562_Hela3.02976686
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61797003
9EWS_26573619_Chip-Seq_HEK293_Human2.46385050
10VDR_23849224_ChIP-Seq_CD4+_Human2.46060729
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.42683070
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40927305
13ELK1_19687146_ChIP-ChIP_HELA_Human2.40440285
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.35990109
15FUS_26573619_Chip-Seq_HEK293_Human2.22073066
16TAF15_26573619_Chip-Seq_HEK293_Human2.20353953
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.19730520
18VDR_22108803_ChIP-Seq_LS180_Human2.11596781
19MYC_18940864_ChIP-ChIP_HL60_Human2.07475661
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06682491
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03299119
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91809768
23FOXP3_21729870_ChIP-Seq_TREG_Human1.86205370
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85170856
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84254625
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81636655
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72959720
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.71671423
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.71651816
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.70896684
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70807769
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.67382477
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58530582
34EZH2_22144423_ChIP-Seq_EOC_Human1.52876070
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.50867825
36ER_23166858_ChIP-Seq_MCF-7_Human1.49738595
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48916831
38IRF1_19129219_ChIP-ChIP_H3396_Human1.48915075
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.48729301
40P300_19829295_ChIP-Seq_ESCs_Human1.48102886
41GBX2_23144817_ChIP-Seq_PC3_Human1.45974817
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43920047
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42786656
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42005835
45TTF2_22483619_ChIP-Seq_HELA_Human1.34597421
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33561132
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32794075
48TP53_22573176_ChIP-Seq_HFKS_Human1.30716151
49RNF2_27304074_Chip-Seq_NSC_Mouse1.27854335
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.24587914
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24361240
52AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23712034
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23690641
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23080731
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.19017412
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17643094
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15199499
58CBP_20019798_ChIP-Seq_JUKART_Human1.14869508
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14869508
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14530768
61GABP_19822575_ChIP-Seq_HepG2_Human1.13620429
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.12653418
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12653418
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10464575
65NANOG_19829295_ChIP-Seq_ESCs_Human1.09128740
66SOX2_19829295_ChIP-Seq_ESCs_Human1.09128740
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06776193
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.06396488
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05631415
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04528005
71MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04175509
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03619873
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.03532516
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.01577474
75FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98256877
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98174973
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98016206
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97414218
79CBX2_27304074_Chip-Seq_ESCs_Mouse0.96007853
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94964277
81DCP1A_22483619_ChIP-Seq_HELA_Human0.94507107
82IGF1R_20145208_ChIP-Seq_DFB_Human0.93929596
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93000996
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92576624
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92433989
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92258278
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92258278
88NFE2_27457419_Chip-Seq_LIVER_Mouse0.91936787
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91792449
90GATA3_26560356_Chip-Seq_TH2_Human0.90574512
91BCAT_22108803_ChIP-Seq_LS180_Human0.89703800
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.88803818
93AR_20517297_ChIP-Seq_VCAP_Human0.86859169
94HOXB7_26014856_ChIP-Seq_BT474_Human0.86809265
95TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85472501
96XRN2_22483619_ChIP-Seq_HELA_Human0.84826795
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84460977
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.83073503
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82700092
100SOX2_16153702_ChIP-ChIP_HESCs_Human0.82466942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.67376187
2MP0002138_abnormal_hepatobiliary_system3.45101682
3MP0006072_abnormal_retinal_apoptosis2.87806797
4MP0005646_abnormal_pituitary_gland2.50475082
5MP0008058_abnormal_DNA_repair2.44598404
6MP0003567_abnormal_fetal_cardiomyocyte2.40443516
7MP0002837_dystrophic_cardiac_calcinosis2.24062559
8MP0004133_heterotaxia2.15867980
9MP0000566_synostosis2.13251757
10MP0008875_abnormal_xenobiotic_pharmacok2.11797469
11MP0008872_abnormal_physiological_respon2.09483470
12MP0003693_abnormal_embryo_hatching2.09480481
13MP0001348_abnormal_lacrimal_gland2.06825964
14MP0003786_premature_aging1.99422288
15MP0008877_abnormal_DNA_methylation1.98913407
16MP0008789_abnormal_olfactory_epithelium1.97637341
17MP0006292_abnormal_olfactory_placode1.86851597
18MP0005084_abnormal_gallbladder_morpholo1.83789724
19MP0008995_early_reproductive_senescence1.77788035
20MP0003718_maternal_effect1.74128919
21MP0002277_abnormal_respiratory_mucosa1.74021690
22MP0000372_irregular_coat_pigmentation1.73933741
23MP0001968_abnormal_touch/_nociception1.73518951
24MP0005551_abnormal_eye_electrophysiolog1.71576662
25MP0000383_abnormal_hair_follicle1.67590851
26MP0004142_abnormal_muscle_tone1.67104267
27MP0001293_anophthalmia1.66803056
28MP0005394_taste/olfaction_phenotype1.64821433
29MP0005499_abnormal_olfactory_system1.64821433
30MP0003806_abnormal_nucleotide_metabolis1.59705800
31MP0001485_abnormal_pinna_reflex1.54657362
32MP0003195_calcinosis1.54430163
33MP0005671_abnormal_response_to1.53763504
34MP0006276_abnormal_autonomic_nervous1.53194913
35MP0003283_abnormal_digestive_organ1.47515055
36MP0004145_abnormal_muscle_electrophysio1.46316291
37MP0005253_abnormal_eye_physiology1.45916950
38MP0001501_abnormal_sleep_pattern1.40001355
39MP0000685_abnormal_immune_system1.36736104
40MP0003878_abnormal_ear_physiology1.36233324
41MP0005377_hearing/vestibular/ear_phenot1.36233324
42MP0002272_abnormal_nervous_system1.34696341
43MP0004885_abnormal_endolymph1.30805134
44MP0000631_abnormal_neuroendocrine_gland1.30496286
45MP0001486_abnormal_startle_reflex1.29588430
46MP0000569_abnormal_digit_pigmentation1.28263336
47MP0003011_delayed_dark_adaptation1.28036661
48MP0001984_abnormal_olfaction1.27972442
49MP0000049_abnormal_middle_ear1.25747754
50MP0002638_abnormal_pupillary_reflex1.24026181
51MP0001529_abnormal_vocalization1.19269068
52MP0004147_increased_porphyrin_level1.18208233
53MP0009745_abnormal_behavioral_response1.18187641
54MP0001835_abnormal_antigen_presentation1.17458774
55MP0005085_abnormal_gallbladder_physiolo1.15429097
56MP0003937_abnormal_limbs/digits/tail_de1.15399385
57MP0001764_abnormal_homeostasis1.14015109
58MP0005410_abnormal_fertilization1.12123794
59MP0003880_abnormal_central_pattern1.11360739
60MP0005389_reproductive_system_phenotype1.09690145
61MP0003119_abnormal_digestive_system1.08462293
62MP0002006_tumorigenesis1.08111187
63MP0002736_abnormal_nociception_after1.07193023
64MP0002751_abnormal_autonomic_nervous1.05657776
65MP0002938_white_spotting1.03268726
66MP0002822_catalepsy1.00669564
67MP0005310_abnormal_salivary_gland1.00142217
68MP0004742_abnormal_vestibular_system0.96375532
69MP0006036_abnormal_mitochondrial_physio0.95601374
70MP0009046_muscle_twitch0.93304124
71MP0002160_abnormal_reproductive_system0.93053440
72MP0002234_abnormal_pharynx_morphology0.92522226
73MP0005379_endocrine/exocrine_gland_phen0.91187121
74MP0010386_abnormal_urinary_bladder0.91026786
75MP0003938_abnormal_ear_development0.90955455
76MP0010094_abnormal_chromosome_stability0.89521358
77MP0002166_altered_tumor_susceptibility0.87562175
78MP0002233_abnormal_nose_morphology0.84232264
79MP0002557_abnormal_social/conspecific_i0.82961646
80MP0001919_abnormal_reproductive_system0.82653966
81MP0000613_abnormal_salivary_gland0.82563537
82MP0003890_abnormal_embryonic-extraembry0.79668859
83MP0010678_abnormal_skin_adnexa0.77159828
84MP0005195_abnormal_posterior_eye0.76652646
85MP0003646_muscle_fatigue0.74972875
86MP0000026_abnormal_inner_ear0.74055240
87MP0001188_hyperpigmentation0.73735176
88MP0002282_abnormal_trachea_morphology0.72975980
89MP0001800_abnormal_humoral_immune0.68088194
90MP0002733_abnormal_thermal_nociception0.68024094
91MP0002572_abnormal_emotion/affect_behav0.67800139
92MP0001119_abnormal_female_reproductive0.66585173
93MP0001905_abnormal_dopamine_level0.65489729
94MP0000647_abnormal_sebaceous_gland0.65446148
95MP0001970_abnormal_pain_threshold0.64892523
96MP0009053_abnormal_anal_canal0.64446406
97MP0005391_vision/eye_phenotype0.63349384
98MP0002752_abnormal_somatic_nervous0.62452789
99MP0001790_abnormal_immune_system0.62163641
100MP0005387_immune_system_phenotype0.62163641

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.46858062
2Congenital stationary night blindness (HP:0007642)4.07392726
3Acute encephalopathy (HP:0006846)3.86540784
4Abnormal mitochondria in muscle tissue (HP:0008316)3.84607068
5Progressive macrocephaly (HP:0004481)3.82792922
6Mitochondrial inheritance (HP:0001427)3.49449988
7Increased CSF lactate (HP:0002490)3.25027093
8Abnormality of midbrain morphology (HP:0002418)3.21583124
9Molar tooth sign on MRI (HP:0002419)3.21583124
10Methylmalonic acidemia (HP:0002912)3.06097676
11IgG deficiency (HP:0004315)3.00773992
12Congenital, generalized hypertrichosis (HP:0004540)2.98135142
13Pancreatic cysts (HP:0001737)2.91919631
14Hepatocellular necrosis (HP:0001404)2.91774978
15Type 2 muscle fiber atrophy (HP:0003554)2.88687361
16Fibular aplasia (HP:0002990)2.82345126
17Abnormality of the proximal phalanges of the hand (HP:0009834)2.78015424
183-Methylglutaconic aciduria (HP:0003535)2.77253692
19Renal cortical cysts (HP:0000803)2.72950536
20Nephronophthisis (HP:0000090)2.72170509
21Cerebral edema (HP:0002181)2.68457116
22Hypomagnesemia (HP:0002917)2.67978504
23Hepatic necrosis (HP:0002605)2.67817309
24Aplasia/hypoplasia of the uterus (HP:0008684)2.65459408
25Pancreatic fibrosis (HP:0100732)2.58683619
26Symphalangism affecting the phalanges of the hand (HP:0009773)2.57272552
27Meckel diverticulum (HP:0002245)2.53481854
28True hermaphroditism (HP:0010459)2.53200367
29Abolished electroretinogram (ERG) (HP:0000550)2.51152139
30Abnormal biliary tract physiology (HP:0012439)2.50372163
31Bile duct proliferation (HP:0001408)2.50372163
32Abnormality of the ileum (HP:0001549)2.47570027
33Pendular nystagmus (HP:0012043)2.47460457
34Hypoplasia of the uterus (HP:0000013)2.42021061
35Abnormality of the renal medulla (HP:0100957)2.38064709
36Hyperglycinemia (HP:0002154)2.37348500
37Methylmalonic aciduria (HP:0012120)2.35956930
38Humeroradial synostosis (HP:0003041)2.34848884
39Synostosis involving the elbow (HP:0003938)2.34848884
40Increased serum lactate (HP:0002151)2.34777078
41Abnormality of the renal cortex (HP:0011035)2.29878868
42Muscle fiber atrophy (HP:0100295)2.28272389
43Lactic acidosis (HP:0003128)2.28045284
44Aplasia/Hypoplasia of the spleen (HP:0010451)2.26353718
45Hypothermia (HP:0002045)2.26236094
46Fused cervical vertebrae (HP:0002949)2.23947281
47Intestinal atresia (HP:0011100)2.23944003
48Optic disc pallor (HP:0000543)2.22803848
49Prostate neoplasm (HP:0100787)2.21567541
50Abnormality of the middle phalanges of the toes (HP:0010183)2.17727572
51Asplenia (HP:0001746)2.17254157
52Increased hepatocellular lipid droplets (HP:0006565)2.16553110
53Abnormal rod and cone electroretinograms (HP:0008323)2.15814987
54Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.15727719
55Respiratory failure (HP:0002878)2.15141232
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12022668
57Leukodystrophy (HP:0002415)2.08548430
58Hypoplasia of the pons (HP:0012110)2.06311090
59Abnormality of the phalanges of the 2nd finger (HP:0009541)2.00630758
60Abnormality of the phalanges of the 5th finger (HP:0004213)1.99491510
61Inability to walk (HP:0002540)1.98205104
62Stomatitis (HP:0010280)1.97581874
63Abnormality of magnesium homeostasis (HP:0004921)1.96718227
64Oral leukoplakia (HP:0002745)1.96674665
65Short 1st metacarpal (HP:0010034)1.96604644
66Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.96604644
67Progressive inability to walk (HP:0002505)1.96108291
68Abnormality of the pons (HP:0007361)1.93905447
69Aplastic anemia (HP:0001915)1.93568912
70Bilateral microphthalmos (HP:0007633)1.93267403
71Abnormality of the neuromuscular junction (HP:0003398)1.89752175
72Fatigable weakness (HP:0003473)1.89752175
73Reduced antithrombin III activity (HP:0001976)1.88816553
74Abnormality of the prostate (HP:0008775)1.87906649
75Supernumerary spleens (HP:0009799)1.87394821
76Atonic seizures (HP:0010819)1.87289345
77Opisthotonus (HP:0002179)1.86827933
78Lethargy (HP:0001254)1.81830864
79Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.81536290
80Hypoplasia of the fovea (HP:0007750)1.81230822
81Aplasia/Hypoplasia of the fovea (HP:0008060)1.81230822
82Lipid accumulation in hepatocytes (HP:0006561)1.80907613
83Abnormality of the 1st metacarpal (HP:0010009)1.78170458
84Adactyly (HP:0009776)1.77627130
85Polyuria (HP:0000103)1.77113568
86Abnormality of serine family amino acid metabolism (HP:0010894)1.77042946
87Abnormality of glycine metabolism (HP:0010895)1.77042946
88Severe combined immunodeficiency (HP:0004430)1.76904240
89Brittle hair (HP:0002299)1.76489919
90Aplasia/Hypoplasia of the uvula (HP:0010293)1.75126959
91Volvulus (HP:0002580)1.74856467
92Colon cancer (HP:0003003)1.73870966
93Gonadotropin excess (HP:0000837)1.71613209
94Gaze-evoked nystagmus (HP:0000640)1.71448923
95Exercise intolerance (HP:0003546)1.70884034
96Short hallux (HP:0010109)1.69249042
97Palpitations (HP:0001962)1.68969846
98Abnormality of the pulmonary veins (HP:0011718)1.68595245
99Renal Fanconi syndrome (HP:0001994)1.68456471
100Multiple enchondromatosis (HP:0005701)1.67378501

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.01425292
2PINK13.41376500
3TSSK63.20827817
4VRK22.97585328
5TXK2.81623114
6ADRBK22.71335794
7NME12.57762453
8NUAK12.44381736
9WNK32.34366403
10ZAK2.33035304
11MKNK12.30970177
12FRK2.24613701
13EIF2AK12.21871408
14PBK2.18825149
15TAOK32.16702342
16TAF12.14877279
17EIF2AK32.13191547
18MST42.07257953
19TLK12.03034911
20SRPK11.94366174
21GRK11.90533132
22VRK11.82356514
23PLK21.59940725
24MKNK21.46677567
25TNIK1.46670263
26PLK31.41306082
27PLK41.36659330
28MAPKAPK31.29478592
29MAPKAPK51.28560689
30KIT1.16213980
31MAP4K11.15534014
32WNK41.11830517
33BCR1.10746571
34CDC71.10427967
35DYRK21.05619651
36TRIM281.02327576
37BCKDK1.01491124
38BUB10.99696070
39OXSR10.98847725
40PHKG20.98371256
41PHKG10.98371256
42BMPR1B0.96577672
43PASK0.95243417
44MAPK130.95064887
45RPS6KA50.90104547
46STK390.83967099
47STK160.81109924
48TNK20.79902076
49NEK10.76929649
50CSNK1G20.71887214
51RPS6KA40.71400201
52TAOK10.71317402
53EIF2AK20.71254243
54INSRR0.67323855
55PRKCE0.66363870
56MATK0.65095252
57TIE10.63890139
58CAMK2A0.63426398
59ALK0.58765170
60ITK0.57725432
61AURKB0.57592171
62CSNK1G10.57526422
63PRKCG0.54428124
64TGFBR10.53297050
65EPHA40.51860702
66CDK30.50918682
67DYRK30.49944863
68CSNK1G30.49041096
69SYK0.47436255
70LYN0.46660003
71WEE10.46315945
72IKBKE0.46051464
73IKBKB0.45384646
74PLK10.44426062
75CSNK1A10.44067736
76CSNK2A10.43450618
77MAP2K20.41827212
78GRK60.41205098
79DAPK10.40746703
80GRK50.40661413
81ATR0.40481348
82CSNK1E0.40013575
83CSNK2A20.39961392
84TTK0.39792576
85PNCK0.38616435
86PIK3CG0.38319831
87CDK80.37769577
88CSNK1A1L0.36567905
89CAMK2B0.36479762
90NEK90.35879891
91TEC0.35461783
92PRKCQ0.34380249
93NME20.33936870
94ADRBK10.33070907
95PRKACA0.32747261
96FLT30.31915278
97ERBB30.31735998
98MUSK0.31327584
99ERBB20.29522412
100PRKCI0.29459774

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.20510700
2Asthma_Homo sapiens_hsa053102.97025125
3RNA polymerase_Homo sapiens_hsa030202.76511050
4Protein export_Homo sapiens_hsa030602.68893528
5Oxidative phosphorylation_Homo sapiens_hsa001902.66295592
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.58073769
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.54338875
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.52067915
9Ribosome_Homo sapiens_hsa030102.33906851
10Parkinsons disease_Homo sapiens_hsa050122.32388610
11Allograft rejection_Homo sapiens_hsa053302.11772435
12Basal transcription factors_Homo sapiens_hsa030221.98954967
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98184601
14Autoimmune thyroid disease_Homo sapiens_hsa053201.94297809
15Sulfur metabolism_Homo sapiens_hsa009201.92401031
16RNA degradation_Homo sapiens_hsa030181.86581684
17Non-homologous end-joining_Homo sapiens_hsa034501.77885733
18Mismatch repair_Homo sapiens_hsa034301.76421217
19One carbon pool by folate_Homo sapiens_hsa006701.67363527
20Nucleotide excision repair_Homo sapiens_hsa034201.61251067
21Huntingtons disease_Homo sapiens_hsa050161.55567437
22Homologous recombination_Homo sapiens_hsa034401.53040850
23Linoleic acid metabolism_Homo sapiens_hsa005911.51047573
24Phototransduction_Homo sapiens_hsa047441.44963157
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43653771
26RNA transport_Homo sapiens_hsa030131.41608787
27Alzheimers disease_Homo sapiens_hsa050101.35007202
28Fanconi anemia pathway_Homo sapiens_hsa034601.34729045
29Nicotine addiction_Homo sapiens_hsa050331.33623093
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33057943
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.30338083
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26882701
33Spliceosome_Homo sapiens_hsa030401.26837045
34Type I diabetes mellitus_Homo sapiens_hsa049401.26424719
35Pyrimidine metabolism_Homo sapiens_hsa002401.25922722
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25832626
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25004897
38DNA replication_Homo sapiens_hsa030301.24839728
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23902707
40Purine metabolism_Homo sapiens_hsa002301.23188683
41Propanoate metabolism_Homo sapiens_hsa006401.20173220
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15562879
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13772709
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13413730
45Graft-versus-host disease_Homo sapiens_hsa053321.09236208
46Cardiac muscle contraction_Homo sapiens_hsa042601.04117230
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03217294
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01888775
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01553084
50Base excision repair_Homo sapiens_hsa034101.00327748
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00115539
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99459881
53Primary immunodeficiency_Homo sapiens_hsa053400.98694734
54Taste transduction_Homo sapiens_hsa047420.98173758
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97316688
56Selenocompound metabolism_Homo sapiens_hsa004500.97225081
57Vitamin B6 metabolism_Homo sapiens_hsa007500.96838077
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93567564
59Tryptophan metabolism_Homo sapiens_hsa003800.92758309
60Butanoate metabolism_Homo sapiens_hsa006500.92428803
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82503921
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82035054
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81559811
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77887124
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.77352842
66Nitrogen metabolism_Homo sapiens_hsa009100.77299262
67Peroxisome_Homo sapiens_hsa041460.74108157
68Pyruvate metabolism_Homo sapiens_hsa006200.70722186
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69469484
70Chemical carcinogenesis_Homo sapiens_hsa052040.69322491
71Retinol metabolism_Homo sapiens_hsa008300.65865729
72Morphine addiction_Homo sapiens_hsa050320.65843491
73Antigen processing and presentation_Homo sapiens_hsa046120.64840016
74Rheumatoid arthritis_Homo sapiens_hsa053230.62641732
75Ether lipid metabolism_Homo sapiens_hsa005650.61157277
76Metabolic pathways_Homo sapiens_hsa011000.59881839
77beta-Alanine metabolism_Homo sapiens_hsa004100.58996082
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58491840
79Systemic lupus erythematosus_Homo sapiens_hsa053220.56780436
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.55383761
81Fat digestion and absorption_Homo sapiens_hsa049750.55265692
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53635242
83Caffeine metabolism_Homo sapiens_hsa002320.52871893
84Arachidonic acid metabolism_Homo sapiens_hsa005900.52484921
85Folate biosynthesis_Homo sapiens_hsa007900.50625038
86Olfactory transduction_Homo sapiens_hsa047400.49018898
87Hematopoietic cell lineage_Homo sapiens_hsa046400.45428331
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44952229
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.44875875
90Glutathione metabolism_Homo sapiens_hsa004800.43771909
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43002424
92Regulation of autophagy_Homo sapiens_hsa041400.40922728
93GABAergic synapse_Homo sapiens_hsa047270.40871796
94Tyrosine metabolism_Homo sapiens_hsa003500.39005979
95Steroid biosynthesis_Homo sapiens_hsa001000.38980362
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36251266
97Glycerolipid metabolism_Homo sapiens_hsa005610.29517407
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28777720
99Viral myocarditis_Homo sapiens_hsa054160.26318352
100Serotonergic synapse_Homo sapiens_hsa047260.23780574

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