ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.20386711
2	ATP synthesis coupled proton transport (GO:0015986)	5.72015028
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.72015028
4	sulfation (GO:0051923)	5.62489413
5	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.59287682
6	activated T cell proliferation (GO:0050798)	5.15257016
7	DNA deamination (GO:0045006)	5.14808958
8	fucose catabolic process (GO:0019317)	4.88277386
9	L-fucose metabolic process (GO:0042354)	4.88277386
10	L-fucose catabolic process (GO:0042355)	4.88277386
11	protein neddylation (GO:0045116)	4.65072292
12	sequestering of actin monomers (GO:0042989)	4.40053567
13	cullin deneddylation (GO:0010388)	4.27122624
14	water-soluble vitamin biosynthetic process (GO:0042364)	4.26906478
15	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.24573584
16	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.15202748
17	GMP metabolic process (GO:0046037)	3.84323783
18	protein deneddylation (GO:0000338)	3.81910848
19	purine-containing compound salvage (GO:0043101)	3.73918676
20	negative regulation of telomere maintenance (GO:0032205)	3.67191090
21	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.51022920
22	chaperone-mediated protein transport (GO:0072321)	3.43260715
23	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.43192710
24	sleep (GO:0030431)	3.33765022
25	electron transport chain (GO:0022900)	3.30356833
26	respiratory electron transport chain (GO:0022904)	3.29561709
27	vascular smooth muscle contraction (GO:0014829)	3.20018711
28	parturition (GO:0007567)	3.19644945
29	ATP biosynthetic process (GO:0006754)	3.17374637
30	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.15988325
31	response to pheromone (GO:0019236)	3.11475202
32	protein-cofactor linkage (GO:0018065)	3.06677626
33	regulation of mesoderm development (GO:2000380)	3.06058282
34	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.04742919
35	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.01250752
36	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.00342181
37	artery smooth muscle contraction (GO:0014824)	2.98591280
38	proteasome assembly (GO:0043248)	2.96402295
39	DNA replication-dependent nucleosome organization (GO:0034723)	2.94260377
40	DNA replication-dependent nucleosome assembly (GO:0006335)	2.94260377
41	regulation of chronic inflammatory response (GO:0002676)	2.91934355
42	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.90462645
43	inner mitochondrial membrane organization (GO:0007007)	2.90372025
44	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.89886855
45	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.89886855
46	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.89886855
47	hematopoietic stem cell proliferation (GO:0071425)	2.86257636
48	potassium ion export (GO:0071435)	2.86171192
49	gamma-aminobutyric acid transport (GO:0015812)	2.85219004
50	regulation of cellular amino acid metabolic process (GO:0006521)	2.85065854
51	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.85033402
52	GPI anchor metabolic process (GO:0006505)	2.81351037
53	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.75940803
54	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.75940803
55	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.75880685
56	base-excision repair, AP site formation (GO:0006285)	2.75523510
57	DNA damage response, detection of DNA damage (GO:0042769)	2.74801547
58	protein complex biogenesis (GO:0070271)	2.74648275
59	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.73700279
60	GPI anchor biosynthetic process (GO:0006506)	2.73461111
61	positive regulation of hair cycle (GO:0042635)	2.73281305
62	positive regulation of hair follicle development (GO:0051798)	2.73281305
63	glycerophospholipid catabolic process (GO:0046475)	2.72970437
64	DNA replication checkpoint (GO:0000076)	2.72627182
65	regulation of defense response to virus by host (GO:0050691)	2.72272463
66	pseudouridine synthesis (GO:0001522)	2.71980700
67	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.70774350
68	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.70774350
69	viral mRNA export from host cell nucleus (GO:0046784)	2.70501200
70	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.70387036
71	NAD biosynthetic process (GO:0009435)	2.69464616
72	rhodopsin mediated signaling pathway (GO:0016056)	2.68422624
73	replicative senescence (GO:0090399)	2.66613311
74	GTP biosynthetic process (GO:0006183)	2.64742477
75	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.64294257
76	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.64294257
77	negative regulation of ligase activity (GO:0051352)	2.61652534
78	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.61652534
79	tonic smooth muscle contraction (GO:0014820)	2.59241051
80	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.57650593
81	mitochondrial respiratory chain complex assembly (GO:0033108)	2.57584777
82	vitamin biosynthetic process (GO:0009110)	2.56651207
83	nonmotile primary cilium assembly (GO:0035058)	2.54807040
84	neurotransmitter-gated ion channel clustering (GO:0072578)	2.54001043
85	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.53357206
86	detection of light stimulus involved in visual perception (GO:0050908)	2.52687170
87	detection of light stimulus involved in sensory perception (GO:0050962)	2.52687170
88	termination of RNA polymerase III transcription (GO:0006386)	2.48850699
89	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.48850699
90	hydrogen ion transmembrane transport (GO:1902600)	2.48466614
91	positive regulation of meiosis (GO:0045836)	2.47895987
92	xenobiotic catabolic process (GO:0042178)	2.47714172
93	platelet dense granule organization (GO:0060155)	2.46839348
94	cytidine metabolic process (GO:0046087)	2.46490779
95	cytidine catabolic process (GO:0006216)	2.46490779
96	cytidine deamination (GO:0009972)	2.46490779
97	regulation of penile erection (GO:0060405)	2.46443561
98	oxidative phosphorylation (GO:0006119)	2.45693286
99	vocalization behavior (GO:0071625)	2.45507083
100	fusion of sperm to egg plasma membrane (GO:0007342)	2.43610777

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.12126139
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.79103715
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.55000703
4	VDR_22108803_ChIP-Seq_LS180_Human	3.28863609
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.97113788
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.96159617
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.90260404
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.67191542
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.62493340
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.57012763
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.42802951
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.22741037
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.19637269
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.11597356
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.11430085
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.10339543
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.00078403
18	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.96664754
19	EWS_26573619_Chip-Seq_HEK293_Human	1.92583757
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.91426646
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.85067565
22	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.83244810
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.82219626
24	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.82170445
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.75967630
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.75813142
27	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.73497045
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.72609156
29	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.66818066
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.66165646
31	P300_19829295_ChIP-Seq_ESCs_Human	1.66094710
32	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.65016555
33	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.64161624
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.63515348
35	FUS_26573619_Chip-Seq_HEK293_Human	1.61533156
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.61415244
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.58556374
38	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.58299781
39	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.57588748
40	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.57248269
41	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.56578266
42	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.53822984
43	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.43021880
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.41418696
45	TAF15_26573619_Chip-Seq_HEK293_Human	1.39784352
46	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.39212204
47	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.38494489
48	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.35974969
49	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.34100129
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.33707633
51	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.30056605
52	GBX2_23144817_ChIP-Seq_PC3_Human	1.26889497
53	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.24725659
54	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.24204039
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.21409535
56	AR_20517297_ChIP-Seq_VCAP_Human	1.21129389
57	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.19428216
58	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.18504970
59	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.17960707
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.17586665
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.17586665
62	HTT_18923047_ChIP-ChIP_STHdh_Human	1.15793765
63	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13425837
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12779967
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12779967
66	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.12325758
67	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.11474297
68	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.10974012
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09181895
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09181895
71	NCOR_22424771_ChIP-Seq_293T_Human	1.08888232
72	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.08429965
73	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.08125874
74	NANOG_20526341_ChIP-Seq_ESCs_Human	1.06692610
75	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.06635459
76	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04581154
77	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.04456231
78	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.01966300
79	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.01687400
80	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.00544757
81	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.95000737
82	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.94316182
83	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94312737
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94248292
85	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.92983539
86	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.92585643
87	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.90703453
88	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.90226659
89	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.90087093
90	RXR_22108803_ChIP-Seq_LS180_Human	0.90034038
91	CIITA_25753668_ChIP-Seq_RAJI_Human	0.89601115
92	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.89476223
93	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.88129161
94	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.87993579
95	TCF4_22108803_ChIP-Seq_LS180_Human	0.87275414
96	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.86938869
97	TAF2_19829295_ChIP-Seq_ESCs_Human	0.86389826
98	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.86265215
99	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.85408355
100	AR_25329375_ChIP-Seq_VCAP_Human	0.84963490

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	5.38914284
2	MP0002653_abnormal_ependyma_morphology	4.23715462
3	MP0005377_hearing/vestibular/ear_phenot	4.06759089
4	MP0003878_abnormal_ear_physiology	4.06759089
5	MP0002102_abnormal_ear_morphology	3.34162237
6	MP0006072_abnormal_retinal_apoptosis	3.20358730
7	MP0005671_abnormal_response_to	2.80606799
8	MP0003787_abnormal_imprinting	2.47905430
9	MP0005171_absent_coat_pigmentation	2.44921945
10	MP0005084_abnormal_gallbladder_morpholo	2.18588953
11	MP0001485_abnormal_pinna_reflex	2.10768809
12	MP0000372_irregular_coat_pigmentation	2.09541393
13	MP0006276_abnormal_autonomic_nervous	1.94147699
14	MP0001529_abnormal_vocalization	1.90249133
15	MP0005646_abnormal_pituitary_gland	1.84439110
16	MP0002736_abnormal_nociception_after	1.81369443
17	MP0004885_abnormal_endolymph	1.81247075
18	MP0005551_abnormal_eye_electrophysiolog	1.78856661
19	MP0001501_abnormal_sleep_pattern	1.76311407
20	MP0008872_abnormal_physiological_respon	1.75718287
21	MP0002272_abnormal_nervous_system	1.74970445
22	MP0003283_abnormal_digestive_organ	1.73947996
23	MP0002751_abnormal_autonomic_nervous	1.73789802
24	MP0003123_paternal_imprinting	1.72615919
25	MP0008877_abnormal_DNA_methylation	1.64742251
26	MP0001984_abnormal_olfaction	1.54963561
27	MP0001486_abnormal_startle_reflex	1.53102738
28	MP0002876_abnormal_thyroid_physiology	1.52676008
29	MP0005220_abnormal_exocrine_pancreas	1.51958537
30	MP0008058_abnormal_DNA_repair	1.51502909
31	MP0000631_abnormal_neuroendocrine_gland	1.49752864
32	MP0006292_abnormal_olfactory_placode	1.46707944
33	MP0001968_abnormal_touch/_nociception	1.42420982
34	MP0003567_abnormal_fetal_cardiomyocyte	1.40336314
35	MP0005187_abnormal_penis_morphology	1.28641652
36	MP0001661_extended_life_span	1.26896606
37	MP0003763_abnormal_thymus_physiology	1.26823543
38	MP0005253_abnormal_eye_physiology	1.24542256
39	MP0005645_abnormal_hypothalamus_physiol	1.24018893
40	MP0010094_abnormal_chromosome_stability	1.19294242
41	MP0003693_abnormal_embryo_hatching	1.18743579
42	MP0008789_abnormal_olfactory_epithelium	1.18681948
43	MP0001919_abnormal_reproductive_system	1.14025587
44	MP0003121_genomic_imprinting	1.13516708
45	MP0002928_abnormal_bile_duct	1.11506908
46	MP0009697_abnormal_copulation	1.09501172
47	MP0004133_heterotaxia	1.02739293
48	MP0005389_reproductive_system_phenotype	1.02638738
49	MP0005085_abnormal_gallbladder_physiolo	1.01850472
50	MP0004142_abnormal_muscle_tone	1.01422253
51	MP0003195_calcinosis	1.00597367
52	MP0004742_abnormal_vestibular_system	1.00072268
53	MP0000566_synostosis	0.98004074
54	MP0002090_abnormal_vision	0.97405660
55	MP0001293_anophthalmia	0.96311163
56	MP0002138_abnormal_hepatobiliary_system	0.93551153
57	MP0000613_abnormal_salivary_gland	0.92361073
58	MP0001727_abnormal_embryo_implantation	0.90007166
59	MP0001873_stomach_inflammation	0.89543554
60	MP0004924_abnormal_behavior	0.89142714
61	MP0005386_behavior/neurological_phenoty	0.89142714
62	MP0006036_abnormal_mitochondrial_physio	0.88004304
63	MP0001502_abnormal_circadian_rhythm	0.87412696
64	MP0002557_abnormal_social/conspecific_i	0.87389984
65	MP0002160_abnormal_reproductive_system	0.84152404
66	MP0008875_abnormal_xenobiotic_pharmacok	0.82539086
67	MP0009785_altered_susceptibility_to	0.82304620
68	MP0005332_abnormal_amino_acid	0.81534091
69	MP0005410_abnormal_fertilization	0.79199011
70	MP0002277_abnormal_respiratory_mucosa	0.78829225
71	MP0003866_abnormal_defecation	0.78625079
72	MP0005195_abnormal_posterior_eye	0.78449722
73	MP0008995_early_reproductive_senescence	0.78433320
74	MP0003122_maternal_imprinting	0.78083128
75	MP0003111_abnormal_nucleus_morphology	0.77943921
76	MP0000026_abnormal_inner_ear	0.77738504
77	MP0000490_abnormal_crypts_of	0.76325133
78	MP0001970_abnormal_pain_threshold	0.76273642
79	MP0003786_premature_aging	0.76266010
80	MP0003638_abnormal_response/metabolism_	0.75132175
81	MP0001963_abnormal_hearing_physiology	0.75117149
82	MP0000647_abnormal_sebaceous_gland	0.75108093
83	MP0003698_abnormal_male_reproductive	0.74984723
84	MP0003937_abnormal_limbs/digits/tail_de	0.74907456
85	MP0001764_abnormal_homeostasis	0.73532697
86	MP0004147_increased_porphyrin_level	0.73428978
87	MP0005075_abnormal_melanosome_morpholog	0.73122003
88	MP0001929_abnormal_gametogenesis	0.73055461
89	MP0002733_abnormal_thermal_nociception	0.71922251
90	MP0002938_white_spotting	0.71882569
91	MP0001663_abnormal_digestive_system	0.70174362
92	MP0000955_abnormal_spinal_cord	0.70012837
93	MP0002067_abnormal_sensory_capabilities	0.69869338
94	MP0000653_abnormal_sex_gland	0.69743867
95	MP0008775_abnormal_heart_ventricle	0.68988233
96	MP0001119_abnormal_female_reproductive	0.68772126
97	MP0003724_increased_susceptibility_to	0.68155375
98	MP0002572_abnormal_emotion/affect_behav	0.68096669
99	MP0000230_abnormal_systemic_arterial	0.67937111
100	MP0009046_muscle_twitch	0.67656354

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	3.43904304
2	Lipid accumulation in hepatocytes (HP:0006561)	3.33358888
3	Visual hallucinations (HP:0002367)	3.23722266
4	Acute necrotizing encephalopathy (HP:0006965)	3.21165396
5	Autoimmune thrombocytopenia (HP:0001973)	3.15925878
6	Congenital stationary night blindness (HP:0007642)	3.14181192
7	Mitochondrial inheritance (HP:0001427)	3.13628533
8	Hypomagnesemia (HP:0002917)	3.10082543
9	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.09655679
10	Absent/shortened dynein arms (HP:0200106)	3.09655679
11	Acute encephalopathy (HP:0006846)	3.09596440
12	Spastic diplegia (HP:0001264)	3.04404033
13	Prostate neoplasm (HP:0100787)	3.03475871
14	Abnormality of the labia minora (HP:0012880)	3.01831011
15	Septo-optic dysplasia (HP:0100842)	3.01121533
16	Abolished electroretinogram (ERG) (HP:0000550)	2.98566760
17	Aplasia/hypoplasia of the uterus (HP:0008684)	2.92611672
18	Abnormal mitochondria in muscle tissue (HP:0008316)	2.90634444
19	Testicular atrophy (HP:0000029)	2.88364176
20	Hyperglycinemia (HP:0002154)	2.87341048
21	Progressive cerebellar ataxia (HP:0002073)	2.87261200
22	True hermaphroditism (HP:0010459)	2.82867105
23	Increased CSF lactate (HP:0002490)	2.77497347
24	Progressive macrocephaly (HP:0004481)	2.69706034
25	Hepatocellular necrosis (HP:0001404)	2.68716465
26	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.68711671
27	Asplenia (HP:0001746)	2.68301207
28	Hypothermia (HP:0002045)	2.62990951
29	Abnormality of midbrain morphology (HP:0002418)	2.60967256
30	Molar tooth sign on MRI (HP:0002419)	2.60967256
31	Rib fusion (HP:0000902)	2.60082308
32	Abnormal auditory evoked potentials (HP:0006958)	2.59039041
33	Hyperphosphaturia (HP:0003109)	2.57192439
34	Abnormality of the diencephalon (HP:0010662)	2.53431155
35	Abnormal number of erythroid precursors (HP:0012131)	2.49711512
36	Abnormal ciliary motility (HP:0012262)	2.46882497
37	Pancreatic cysts (HP:0001737)	2.43886240
38	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.43433168
39	Autoimmune hemolytic anemia (HP:0001890)	2.43106260
40	Increased intramyocellular lipid droplets (HP:0012240)	2.42834065
41	Abnormality of magnesium homeostasis (HP:0004921)	2.41659663
42	Methylmalonic acidemia (HP:0002912)	2.40937199
43	Renal Fanconi syndrome (HP:0001994)	2.39815310
44	Horizontal nystagmus (HP:0000666)	2.38640960
45	Increased serum lactate (HP:0002151)	2.36740270
46	Constricted visual fields (HP:0001133)	2.32799663
47	Type II lissencephaly (HP:0007260)	2.32026725
48	Hepatic necrosis (HP:0002605)	2.29895843
49	Cerebral edema (HP:0002181)	2.29438870
50	Methylmalonic aciduria (HP:0012120)	2.27401569
51	Optic disc pallor (HP:0000543)	2.26122726
52	Esophageal atresia (HP:0002032)	2.24562803
53	Polyphagia (HP:0002591)	2.23413366
54	Abnormal respiratory motile cilium physiology (HP:0012261)	2.21340723
55	Hypoplasia of the uterus (HP:0000013)	2.18270285
56	Abnormal respiratory epithelium morphology (HP:0012253)	2.17867478
57	Abnormal respiratory motile cilium morphology (HP:0005938)	2.17867478
58	Exertional dyspnea (HP:0002875)	2.16616082
59	Cerebellar dysplasia (HP:0007033)	2.16004415
60	Concave nail (HP:0001598)	2.15157787
61	Pancreatic fibrosis (HP:0100732)	2.10961267
62	Retinal dysplasia (HP:0007973)	2.10644117
63	Tubulointerstitial fibrosis (HP:0005576)	2.08812557
64	Large for gestational age (HP:0001520)	2.08796745
65	Central scotoma (HP:0000603)	2.08295654
66	Abnormality of the prostate (HP:0008775)	2.08169855
67	Chronic hepatic failure (HP:0100626)	2.07811066
68	Sclerocornea (HP:0000647)	2.05545366
69	Scotoma (HP:0000575)	2.05385791
70	Abnormality of cells of the erythroid lineage (HP:0012130)	2.03850012
71	Increased muscle lipid content (HP:0009058)	2.00956707
72	Opisthotonus (HP:0002179)	2.00361811
73	Abnormality of purine metabolism (HP:0004352)	2.00330694
74	Hypoplasia of the fovea (HP:0007750)	1.99543242
75	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.99543242
76	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.97570397
77	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.97570397
78	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.96060236
79	Polyuria (HP:0000103)	1.95722592
80	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.95495150
81	Dyschromatopsia (HP:0007641)	1.94968170
82	Lactic acidosis (HP:0003128)	1.93400472
83	Abnormality of the pons (HP:0007361)	1.93289014
84	3-Methylglutaconic aciduria (HP:0003535)	1.93169653
85	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.90586310
86	Metabolic alkalosis (HP:0200114)	1.89944075
87	Hyperventilation (HP:0002883)	1.88987709
88	Abnormal urine output (HP:0012590)	1.88493277
89	Renal salt wasting (HP:0000127)	1.88235432
90	Arthropathy (HP:0003040)	1.87665410
91	Attenuation of retinal blood vessels (HP:0007843)	1.87480312
92	Rhinitis (HP:0012384)	1.86089171
93	Glycosuria (HP:0003076)	1.84345640
94	Abnormality of urine glucose concentration (HP:0011016)	1.84345640
95	Abnormality of T cells (HP:0002843)	1.81373804
96	Abnormality of serine family amino acid metabolism (HP:0010894)	1.81325692
97	Abnormality of glycine metabolism (HP:0010895)	1.81325692
98	Hypoplasia of the pons (HP:0012110)	1.80856822
99	Nephronophthisis (HP:0000090)	1.79641718
100	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.78227465

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	6.78238571
2	ZAK	5.22913618
3	TLK1	3.88366332
4	MST4	3.33981286
5	MAPK15	3.02455533
6	PNCK	2.69984423
7	TSSK6	2.52890555
8	TNIK	2.51673889
9	MAP4K1	2.47709686
10	TAOK3	2.23961503
11	VRK1	2.16142024
12	CASK	2.11409560
13	KDR	1.99134136
14	BMPR1B	1.80821888
15	TXK	1.71698003
16	CDK8	1.67828345
17	TNK2	1.67535711
18	ADRBK2	1.60391910
19	CDK19	1.56759277
20	WEE1	1.54074457
21	VRK2	1.46112763
22	MAP3K4	1.34696260
23	GRK6	1.30521783
24	GRK1	1.21693661
25	PINK1	1.21384309
26	KIT	1.19703162
27	PASK	1.17081078
28	STK16	1.11141683
29	PLK2	1.09253327
30	TESK2	1.08038380
31	TGFBR1	1.02396315
32	PLK3	0.99395638
33	BMPR2	0.94158335
34	EIF2AK3	0.91026606
35	STK38L	0.88319406
36	CSNK1A1L	0.85267755
37	MKNK1	0.83076793
38	CSNK1G3	0.82345693
39	BCKDK	0.82208116
40	PLK1	0.79328165
41	FES	0.79012498
42	DYRK3	0.78275337
43	NUAK1	0.78188042
44	TRIM28	0.76567387
45	NEK1	0.73341253
46	DYRK2	0.72172910
47	ERBB3	0.68871584
48	CDC7	0.68753346
49	OXSR1	0.65141939
50	TIE1	0.65022872
51	WNK3	0.63862728
52	CSNK1G1	0.63529635
53	SRPK1	0.63356198
54	CHEK2	0.62671169
55	MATK	0.61746646
56	MAP2K6	0.61444363
57	EPHB2	0.58266385
58	SYK	0.58199908
59	PIM1	0.57932519
60	BUB1	0.54114071
61	FRK	0.54091669
62	TAF1	0.53646810
63	CSNK1G2	0.53466071
64	RPS6KA4	0.53049775
65	TTK	0.50975968
66	FLT3	0.50603733
67	PRKCE	0.49443278
68	MAP3K11	0.48509493
69	TBK1	0.47630263
70	LIMK1	0.46723266
71	GRK7	0.46232890
72	MAP2K2	0.44118838
73	CDK3	0.43604762
74	ADRBK1	0.42897650
75	RPS6KA5	0.39802949
76	AURKA	0.37592799
77	ATR	0.37533706
78	INSRR	0.35110140
79	PHKG1	0.31967164
80	PHKG2	0.31967164
81	IKBKB	0.31275330
82	ZAP70	0.31066127
83	IKBKE	0.30970389
84	CSNK1A1	0.30778715
85	LYN	0.30732129
86	OBSCN	0.30688189
87	CSNK2A1	0.30551977
88	FER	0.30329848
89	AURKB	0.29807383
90	PRKCQ	0.29580511
91	MAP2K7	0.27415210
92	EIF2AK2	0.25073847
93	EPHA4	0.23611597
94	CAMK2D	0.23086929
95	NME1	0.22650700
96	KSR1	0.21422815
97	TESK1	0.20740328
98	ATM	0.20444794
99	MYLK	0.20367582
100	PRKCG	0.19277809

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.97991337
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.50187365
3	Parkinsons disease_Homo sapiens_hsa05012	3.03306295
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.01489385
5	RNA polymerase_Homo sapiens_hsa03020	2.44490315
6	Ribosome_Homo sapiens_hsa03010	2.31296283
7	Phototransduction_Homo sapiens_hsa04744	2.30103441
8	Mismatch repair_Homo sapiens_hsa03430	2.10172789
9	Sulfur metabolism_Homo sapiens_hsa00920	2.04290503
10	Alzheimers disease_Homo sapiens_hsa05010	1.98877858
11	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.95978685
12	Huntingtons disease_Homo sapiens_hsa05016	1.95428813
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.85431593
14	RNA degradation_Homo sapiens_hsa03018	1.81656482
15	Protein export_Homo sapiens_hsa03060	1.79761563
16	Propanoate metabolism_Homo sapiens_hsa00640	1.79409838
17	Antigen processing and presentation_Homo sapiens_hsa04612	1.64913930
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.58640773
19	Spliceosome_Homo sapiens_hsa03040	1.57214407
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.55981116
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.54874644
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.53525617
23	Steroid biosynthesis_Homo sapiens_hsa00100	1.51423302
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.45812257
25	DNA replication_Homo sapiens_hsa03030	1.45213821
26	Asthma_Homo sapiens_hsa05310	1.44235850
27	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.42718601
28	Graft-versus-host disease_Homo sapiens_hsa05332	1.39984365
29	Homologous recombination_Homo sapiens_hsa03440	1.38986187
30	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.35302266
31	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.34634262
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34413890
33	Type I diabetes mellitus_Homo sapiens_hsa04940	1.33357422
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.32820183
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.31935281
36	Allograft rejection_Homo sapiens_hsa05330	1.30856520
37	One carbon pool by folate_Homo sapiens_hsa00670	1.30308479
38	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.25884488
39	Basal transcription factors_Homo sapiens_hsa03022	1.25371610
40	Fanconi anemia pathway_Homo sapiens_hsa03460	1.17311727
41	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.16081941
42	Butanoate metabolism_Homo sapiens_hsa00650	1.13220124
43	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.11640579
44	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.09749110
45	Pyrimidine metabolism_Homo sapiens_hsa00240	1.08885164
46	Taste transduction_Homo sapiens_hsa04742	1.08178152
47	Nucleotide excision repair_Homo sapiens_hsa03420	1.06525278
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.03272140
49	Purine metabolism_Homo sapiens_hsa00230	1.00357389
50	Caffeine metabolism_Homo sapiens_hsa00232	1.00071841
51	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.99981191
52	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.99000707
53	Base excision repair_Homo sapiens_hsa03410	0.97776003
54	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.97075756
55	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.95667883
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.94555094
57	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.94528333
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.89843519
59	RNA transport_Homo sapiens_hsa03013	0.87067244
60	Fatty acid degradation_Homo sapiens_hsa00071	0.83429065
61	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.78881769
62	Rheumatoid arthritis_Homo sapiens_hsa05323	0.75619735
63	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.75492407
64	Regulation of autophagy_Homo sapiens_hsa04140	0.73255970
65	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.72622900
66	Olfactory transduction_Homo sapiens_hsa04740	0.67150534
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.62333071
68	Metabolic pathways_Homo sapiens_hsa01100	0.62297729
69	Retinol metabolism_Homo sapiens_hsa00830	0.61776140
70	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.61626877
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58298615
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.57592784
73	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56855097
74	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.56138302
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.56090692
76	Basal cell carcinoma_Homo sapiens_hsa05217	0.55299067
77	Selenocompound metabolism_Homo sapiens_hsa00450	0.54159005
78	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.53632571
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53054021
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52149568
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51217800
82	Peroxisome_Homo sapiens_hsa04146	0.50752585
83	Fatty acid metabolism_Homo sapiens_hsa01212	0.48950025
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.47349768
85	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46934013
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46465227
87	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.45164515
88	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.45084510
89	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.44509326
90	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.40255345
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.37172769
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36440740
93	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.35990149
94	Nicotine addiction_Homo sapiens_hsa05033	0.34489784
95	Glutathione metabolism_Homo sapiens_hsa00480	0.33321284
96	Non-homologous end-joining_Homo sapiens_hsa03450	0.32781667
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.30785904
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.30216965
99	mRNA surveillance pathway_Homo sapiens_hsa03015	0.29880310
100	p53 signaling pathway_Homo sapiens_hsa04115	0.29456334

HNRNPA1P45

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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