HNRNPA1P46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)7.55554438
2pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.98595634
3base-excision repair, AP site formation (GO:0006285)6.74912820
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.48922031
5GDP-mannose metabolic process (GO:0019673)5.78151899
6pyrimidine nucleotide catabolic process (GO:0006244)5.70236285
7cellular response to ATP (GO:0071318)5.53037221
8establishment of protein localization to mitochondrial membrane (GO:0090151)5.35548528
9dolichol-linked oligosaccharide biosynthetic process (GO:0006488)5.21790483
10chaperone-mediated protein transport (GO:0072321)5.12589902
11UDP-N-acetylglucosamine metabolic process (GO:0006047)4.85752517
12pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.55447072
13protein complex biogenesis (GO:0070271)4.49731959
14protein K63-linked deubiquitination (GO:0070536)4.45110672
15glomerular visceral epithelial cell development (GO:0072015)4.40414546
16ATP synthesis coupled proton transport (GO:0015986)4.32343297
17energy coupled proton transport, down electrochemical gradient (GO:0015985)4.32343297
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.22757125
19protein neddylation (GO:0045116)4.18181695
20axonemal dynein complex assembly (GO:0070286)4.17349151
21DNA deamination (GO:0045006)4.16510854
22regulation of mitochondrial translation (GO:0070129)4.15130041
23mitochondrial respiratory chain complex assembly (GO:0033108)4.10094643
24viral mRNA export from host cell nucleus (GO:0046784)4.08528847
25rRNA modification (GO:0000154)4.03977166
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.95816249
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.95816249
28NADH dehydrogenase complex assembly (GO:0010257)3.95816249
29maturation of 5.8S rRNA (GO:0000460)3.83340026
30glomerular epithelial cell development (GO:0072310)3.81414923
31proteasome assembly (GO:0043248)3.77181130
32purine-containing compound salvage (GO:0043101)3.74992346
33mannosylation (GO:0097502)3.72448789
34ribosomal large subunit biogenesis (GO:0042273)3.71279877
35nucleotide-excision repair, DNA damage removal (GO:0000718)3.67804173
36DNA excision (GO:0044349)3.67804173
37regulation of cellular amino acid metabolic process (GO:0006521)3.61217356
38regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.60236070
39regulation of mitotic spindle checkpoint (GO:1903504)3.60236070
40negative regulation of telomere maintenance (GO:0032205)3.56119852
41activated T cell proliferation (GO:0050798)3.54456549
42deoxyribonucleotide catabolic process (GO:0009264)3.52556693
43epithelial cilium movement (GO:0003351)3.51108227
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.49775603
45nucleotide-sugar metabolic process (GO:0009225)3.43105032
46rRNA methylation (GO:0031167)3.42716543
47cytochrome complex assembly (GO:0017004)3.41811200
48exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.40963002
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.40428248
50DNA replication checkpoint (GO:0000076)3.39283162
51GTP biosynthetic process (GO:0006183)3.39051015
52rRNA processing (GO:0006364)3.33333513
53water-soluble vitamin biosynthetic process (GO:0042364)3.32090243
54ncRNA catabolic process (GO:0034661)3.28396957
55positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27129853
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.23891017
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.23639493
58rRNA metabolic process (GO:0016072)3.23450187
59spliceosomal snRNP assembly (GO:0000387)3.20574643
60N-acetylglucosamine metabolic process (GO:0006044)3.20532479
61fucose catabolic process (GO:0019317)3.18899618
62L-fucose metabolic process (GO:0042354)3.18899618
63L-fucose catabolic process (GO:0042355)3.18899618
64signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.14658060
65signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.14658060
66signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.14658060
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14368418
68intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.13702486
69signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.13702486
70SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.12226020
71preassembly of GPI anchor in ER membrane (GO:0016254)3.11680192
72nucleotide-sugar biosynthetic process (GO:0009226)3.09583659
73protein targeting to ER (GO:0045047)3.09531438
74transcription elongation from RNA polymerase III promoter (GO:0006385)3.09196735
75termination of RNA polymerase III transcription (GO:0006386)3.09196735
76deoxyribose phosphate catabolic process (GO:0046386)3.07939137
77cotranslational protein targeting to membrane (GO:0006613)3.07231202
78viral transcription (GO:0019083)3.05883556
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.05450899
80negative regulation of ligase activity (GO:0051352)3.05450899
817-methylguanosine mRNA capping (GO:0006370)3.04588431
82cellular component biogenesis (GO:0044085)3.02558222
83electron transport chain (GO:0022900)3.01413093
84ribosomal small subunit biogenesis (GO:0042274)3.01176733
85ribosomal small subunit assembly (GO:0000028)3.01121036
86rRNA catabolic process (GO:0016075)2.99692966
87signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98767236
88signal transduction involved in DNA damage checkpoint (GO:0072422)2.98767236
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98743490
90respiratory electron transport chain (GO:0022904)2.97497225
917-methylguanosine RNA capping (GO:0009452)2.96758213
92RNA capping (GO:0036260)2.96758213
93translation (GO:0006412)2.96188775
94protein localization to endoplasmic reticulum (GO:0070972)2.96181737
95signal transduction involved in cell cycle checkpoint (GO:0072395)2.95406130
96protein K48-linked deubiquitination (GO:0071108)2.94021808
97translational termination (GO:0006415)2.92003711
98interferon-gamma production (GO:0032609)2.90019656
99behavioral response to nicotine (GO:0035095)2.89017910
100translational elongation (GO:0006414)2.88845551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.70085934
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.40377735
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.21579127
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.95015135
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.53864761
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.52534471
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.49770610
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.16259527
9VDR_22108803_ChIP-Seq_LS180_Human3.08392592
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.86277233
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.85325692
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.79029237
13VDR_23849224_ChIP-Seq_CD4+_Human2.74702122
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.65363742
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.60986912
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60365040
17MYC_18940864_ChIP-ChIP_HL60_Human2.25792744
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.22617733
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14125527
20ELK1_19687146_ChIP-ChIP_HELA_Human2.13573269
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.13253139
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05737563
23FOXP3_21729870_ChIP-Seq_TREG_Human1.97103147
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.96739452
25POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.85917297
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.84372642
27DCP1A_22483619_ChIP-Seq_HELA_Human1.81430854
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76689584
29TTF2_22483619_ChIP-Seq_HELA_Human1.72047923
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.69797894
31XRN2_22483619_ChIP-Seq_HELA_Human1.68178879
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.66154466
33EWS_26573619_Chip-Seq_HEK293_Human1.65956861
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.62673441
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54036000
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.51826634
37ZNF274_21170338_ChIP-Seq_K562_Hela1.51793864
38ER_23166858_ChIP-Seq_MCF-7_Human1.50589095
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48383017
40GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.44454608
41ELK1_22589737_ChIP-Seq_MCF10A_Human1.43928350
42GABP_19822575_ChIP-Seq_HepG2_Human1.42685976
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39770472
44TP53_22573176_ChIP-Seq_HFKS_Human1.35460885
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34879116
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33395851
47IGF1R_20145208_ChIP-Seq_DFB_Human1.32264846
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30670101
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30176499
50TAF2_19829295_ChIP-Seq_ESCs_Human1.29048319
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27487019
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27030558
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26990346
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24643842
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22956017
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22349538
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21938137
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21923834
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20649467
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20132354
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19607645
62AR_21572438_ChIP-Seq_LNCaP_Human1.17929947
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17069321
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16599948
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15898603
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15332547
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12475525
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11641788
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08299321
70LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06302356
71FOXH1_21741376_ChIP-Seq_EPCs_Human1.05482580
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.03886739
73ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02942710
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01242769
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99458810
76P300_19829295_ChIP-Seq_ESCs_Human0.99284272
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96716355
78HOXB7_26014856_ChIP-Seq_BT474_Human0.96664244
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95617114
80ERA_21632823_ChIP-Seq_H3396_Human0.95502914
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94471388
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93283017
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91191765
84NANOG_20526341_ChIP-Seq_ESCs_Human0.90114715
85AR_20517297_ChIP-Seq_VCAP_Human0.90046286
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89620463
87ERG_20517297_ChIP-Seq_VCAP_Human0.87924221
88CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87099111
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86788619
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85549136
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84770040
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84384666
93GATA3_21878914_ChIP-Seq_MCF-7_Human0.84348699
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84320197
95ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82279951
96ELF5_23300383_ChIP-Seq_T47D_Human0.80104190
97OCT4_20526341_ChIP-Seq_ESCs_Human0.78919399
98SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77404416
99CIITA_25753668_ChIP-Seq_RAJI_Human0.76279956
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.75581025

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.75796131
2MP0005671_abnormal_response_to3.41898956
3MP0005084_abnormal_gallbladder_morpholo3.15267460
4MP0008058_abnormal_DNA_repair3.10364432
5MP0005408_hypopigmentation3.09110169
6MP0003646_muscle_fatigue3.05733867
7MP0002837_dystrophic_cardiac_calcinosis2.78160789
8MP0002102_abnormal_ear_morphology2.65543614
9MP0002938_white_spotting2.48422663
10MP0003786_premature_aging2.26275677
11MP0006292_abnormal_olfactory_placode2.23657741
12MP0004145_abnormal_muscle_electrophysio2.22856610
13MP0002736_abnormal_nociception_after2.15745249
14MP0004957_abnormal_blastocyst_morpholog2.09468412
15MP0000372_irregular_coat_pigmentation2.03965933
16MP0010030_abnormal_orbit_morphology1.99191974
17MP0003890_abnormal_embryonic-extraembry1.97200324
18MP0006072_abnormal_retinal_apoptosis1.96884968
19MP0000569_abnormal_digit_pigmentation1.92738313
20MP0004142_abnormal_muscle_tone1.88474417
21MP0003567_abnormal_fetal_cardiomyocyte1.83260555
22MP0008875_abnormal_xenobiotic_pharmacok1.80803673
23MP0004885_abnormal_endolymph1.77540729
24MP0003045_fibrosis1.72427008
25MP0003763_abnormal_thymus_physiology1.72274977
26MP0000566_synostosis1.68520503
27MP0002876_abnormal_thyroid_physiology1.67880618
28MP0002006_tumorigenesis1.62043909
29MP0001727_abnormal_embryo_implantation1.61037152
30MP0005167_abnormal_blood-brain_barrier1.58883965
31MP0003195_calcinosis1.57362107
32MP0001790_abnormal_immune_system1.49167925
33MP0005387_immune_system_phenotype1.49167925
34MP0008775_abnormal_heart_ventricle1.40694363
35MP0001968_abnormal_touch/_nociception1.40459366
36MP0008995_early_reproductive_senescence1.35692458
37MP0000049_abnormal_middle_ear1.35338362
38MP0008007_abnormal_cellular_replicative1.34743958
39MP0002166_altered_tumor_susceptibility1.33928586
40MP0010094_abnormal_chromosome_stability1.30668660
41MP0001905_abnormal_dopamine_level1.29072669
42MP0004147_increased_porphyrin_level1.27083808
43MP0001666_abnormal_nutrient_absorption1.25447476
44MP0008789_abnormal_olfactory_epithelium1.23375462
45MP0001485_abnormal_pinna_reflex1.23165710
46MP0001293_anophthalmia1.21602891
47MP0003011_delayed_dark_adaptation1.18920834
48MP0002090_abnormal_vision1.18898035
49MP0009785_altered_susceptibility_to1.17742763
50MP0003119_abnormal_digestive_system1.17203554
51MP0005253_abnormal_eye_physiology1.12706356
52MP0003111_abnormal_nucleus_morphology1.11125094
53MP0003950_abnormal_plasma_membrane1.08102838
54MP0001919_abnormal_reproductive_system1.07669946
55MP0005551_abnormal_eye_electrophysiolog1.05031496
56MP0003937_abnormal_limbs/digits/tail_de1.02474167
57MP0001873_stomach_inflammation0.98969162
58MP0005645_abnormal_hypothalamus_physiol0.98587690
59MP0003880_abnormal_central_pattern0.95824511
60MP0000747_muscle_weakness0.93606293
61MP0006036_abnormal_mitochondrial_physio0.92237526
62MP0004133_heterotaxia0.91817254
63MP0003943_abnormal_hepatobiliary_system0.90850732
64MP0008872_abnormal_physiological_respon0.90304415
65MP0002138_abnormal_hepatobiliary_system0.90025552
66MP0002210_abnormal_sex_determination0.88829807
67MP0005389_reproductive_system_phenotype0.87675823
68MP0005670_abnormal_white_adipose0.87207396
69MP0000613_abnormal_salivary_gland0.85719163
70MP0009379_abnormal_foot_pigmentation0.84859727
71MP0009053_abnormal_anal_canal0.84412041
72MP0002277_abnormal_respiratory_mucosa0.84381991
73MP0010368_abnormal_lymphatic_system0.84183030
74MP0003718_maternal_effect0.83739583
75MP0003938_abnormal_ear_development0.83302632
76MP0003866_abnormal_defecation0.82001660
77MP0002928_abnormal_bile_duct0.81579309
78MP0005195_abnormal_posterior_eye0.80583645
79MP0008877_abnormal_DNA_methylation0.80493887
80MP0000653_abnormal_sex_gland0.78324631
81MP0002653_abnormal_ependyma_morphology0.77983001
82MP0003077_abnormal_cell_cycle0.76354814
83MP0000470_abnormal_stomach_morphology0.73585031
84MP0001529_abnormal_vocalization0.72314292
85MP0002405_respiratory_system_inflammati0.71900893
86MP0002084_abnormal_developmental_patter0.71815964
87MP0002254_reproductive_system_inflammat0.69869605
88MP0006082_CNS_inflammation0.69092093
89MP0008057_abnormal_DNA_replication0.65951479
90MP0002160_abnormal_reproductive_system0.65250668
91MP0001145_abnormal_male_reproductive0.65231169
92MP0002067_abnormal_sensory_capabilities0.64938668
93MP0001119_abnormal_female_reproductive0.63252512
94MP0009697_abnormal_copulation0.62871312
95MP0004019_abnormal_vitamin_homeostasis0.62618223
96MP0002234_abnormal_pharynx_morphology0.59622110
97MP0005395_other_phenotype0.59337062
98MP0002420_abnormal_adaptive_immunity0.57633163
99MP0002752_abnormal_somatic_nervous0.57455212
100MP0000749_muscle_degeneration0.57197970

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)5.39623044
2Abnormal protein glycosylation (HP:0012346)5.20026121
3Abnormal glycosylation (HP:0012345)5.20026121
4Abnormal isoelectric focusing of serum transferrin (HP:0003160)5.20026121
5Abnormal protein N-linked glycosylation (HP:0012347)5.20026121
6Reduced antithrombin III activity (HP:0001976)4.82003218
7Abnormal respiratory epithelium morphology (HP:0012253)4.35802059
8Abnormal respiratory motile cilium morphology (HP:0005938)4.35802059
9Hypoproteinemia (HP:0003075)4.16963305
103-Methylglutaconic aciduria (HP:0003535)4.06478202
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.95982815
12Absent/shortened dynein arms (HP:0200106)3.95982815
13Testicular atrophy (HP:0000029)3.72817824
14Abnormality of the pons (HP:0007361)3.70622399
15Acute necrotizing encephalopathy (HP:0006965)3.69756681
16Hypoplasia of the pons (HP:0012110)3.68831412
17Abnormal mitochondria in muscle tissue (HP:0008316)3.51020466
18Abnormality of DNA repair (HP:0003254)3.43576797
19Aplastic anemia (HP:0001915)3.25182332
20Supernumerary spleens (HP:0009799)3.16008385
21Hepatocellular necrosis (HP:0001404)3.13835326
22Esophageal atresia (HP:0002032)3.13228015
23Mitochondrial inheritance (HP:0001427)3.11913664
24Myopathic facies (HP:0002058)3.10169494
25Methylmalonic acidemia (HP:0002912)2.96144667
26Acute encephalopathy (HP:0006846)2.94778070
27Progressive macrocephaly (HP:0004481)2.94575643
28Hepatic necrosis (HP:0002605)2.90689245
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.89752473
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.89752473
31Abnormal ciliary motility (HP:0012262)2.87169302
32Prolonged QT interval (HP:0001657)2.66778994
33Dyschromatopsia (HP:0007641)2.64639684
34Duplicated collecting system (HP:0000081)2.64574440
35Absent speech (HP:0001344)2.61578232
36Increased CSF lactate (HP:0002490)2.61344674
37Autoimmune thrombocytopenia (HP:0001973)2.60131082
38Molar tooth sign on MRI (HP:0002419)2.56839543
39Abnormality of midbrain morphology (HP:0002418)2.56839543
40Abnormal respiratory motile cilium physiology (HP:0012261)2.55086348
41Abnormality of the renal collecting system (HP:0004742)2.50766144
42Methylmalonic aciduria (HP:0012120)2.47008561
43Absent phalangeal crease (HP:0006109)2.46493457
44Symphalangism affecting the phalanges of the hand (HP:0009773)2.46266847
45Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.42823335
46Decreased subcutaneous fat (HP:0001002)2.41210217
47Increased hepatocellular lipid droplets (HP:0006565)2.38277468
48Visual hallucinations (HP:0002367)2.37070919
49Infertility (HP:0000789)2.33898516
50Autoimmune hemolytic anemia (HP:0001890)2.33018363
51Bronchiectasis (HP:0002110)2.32000179
52Abnormality of the phalanges of the 5th finger (HP:0004213)2.30246200
53Reticulocytopenia (HP:0001896)2.22120500
54Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.20227289
55Exercise intolerance (HP:0003546)2.20029259
56Pancytopenia (HP:0001876)2.19506485
57Cerebral edema (HP:0002181)2.17058777
58CNS demyelination (HP:0007305)2.15853533
59Lipid accumulation in hepatocytes (HP:0006561)2.13398588
60Asplenia (HP:0001746)2.10417078
61Poor head control (HP:0002421)2.10341238
62Abnormal finger flexion creases (HP:0006143)2.07762791
63Adrenal hypoplasia (HP:0000835)2.07690297
64Absent thumb (HP:0009777)2.06291756
65Aplasia/Hypoplasia of the spleen (HP:0010451)2.05667669
66Aplasia/Hypoplasia involving the musculature (HP:0001460)2.05164511
67Generalized aminoaciduria (HP:0002909)2.03673296
68Increased neuronal autofluorescent lipopigment (HP:0002074)1.96298071
69Aplasia/Hypoplasia of the uvula (HP:0010293)1.95263391
70Increased intramyocellular lipid droplets (HP:0012240)1.94510546
71Nephronophthisis (HP:0000090)1.94390851
72Exertional dyspnea (HP:0002875)1.93302872
73Abnormality of the vitamin B12 metabolism (HP:0004341)1.92958186
74Large for gestational age (HP:0001520)1.90137667
75Central scotoma (HP:0000603)1.89228337
76Congenital stationary night blindness (HP:0007642)1.87520759
77Gastrointestinal atresia (HP:0002589)1.85901977
78Gout (HP:0001997)1.83748288
79Humeroradial synostosis (HP:0003041)1.83094990
80Synostosis involving the elbow (HP:0003938)1.83094990
81Abnormality of purine metabolism (HP:0004352)1.81721629
82Broad distal phalanx of finger (HP:0009836)1.81633106
83Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81119954
84Nasal polyposis (HP:0100582)1.78237536
85Abnormality of the middle phalanges of the toes (HP:0010183)1.77467082
86Respiratory failure (HP:0002878)1.76918805
87Parakeratosis (HP:0001036)1.75524308
88Hypochromic microcytic anemia (HP:0004840)1.75210996
89Abnormality of the renal cortex (HP:0011035)1.74366312
90Macrocytic anemia (HP:0001972)1.73724006
91Abnormality of vitamin B metabolism (HP:0004340)1.72290714
92Increased serum lactate (HP:0002151)1.72100768
93Cerebral hypomyelination (HP:0006808)1.71644593
94Lactic acidosis (HP:0003128)1.70913681
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.69822547
96Rhinitis (HP:0012384)1.68980613
97Milia (HP:0001056)1.68364242
98Clubbing of toes (HP:0100760)1.66062010
99Abnormality of the labia minora (HP:0012880)1.65270417
100Abnormality of subcutaneous fat tissue (HP:0001001)1.64792162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.30345124
2CAMKK23.17675096
3BCKDK2.88502064
4BUB12.80325604
5GRK12.72679126
6NEK12.71335164
7TXK2.67050031
8NEK92.52043289
9VRK22.41369810
10MAP3K122.36508024
11STK162.15475806
12TSSK62.06377973
13IKBKE2.01064748
14TLK11.97114976
15WNK41.83237015
16EIF2AK11.74264000
17STK391.69953963
18MST41.68910970
19KDR1.66897057
20TESK21.66764950
21INSRR1.62031185
22PLK41.53096401
23WNK31.52356381
24BRSK21.40509049
25TAF11.32124373
26ZAK1.31224654
27OXSR11.25873060
28DAPK21.21995280
29JAK31.21007241
30ADRBK21.18620826
31NUAK11.11907016
32LIMK11.11859678
33TAOK31.11631606
34PNCK1.08359868
35PIK3CG1.06084093
36CHEK21.05908328
37IKBKB1.05695178
38DAPK11.05284915
39EIF2AK31.04266158
40NME11.03261697
41CCNB10.95161512
42WEE10.94487904
43PHKG10.93182658
44PHKG20.93182658
45MAP4K20.91683531
46BRSK10.91064985
47PLK30.90329439
48DYRK20.89588651
49MAP4K10.85782230
50NME20.82412617
51CAMK2D0.81597098
52AURKA0.78257344
53CDK70.77794431
54MAP2K70.75210904
55OBSCN0.72517221
56ATR0.71410553
57CDC70.70422318
58CAMKK10.68737904
59PLK10.68268570
60WNK10.67151541
61CAMK2G0.66001054
62MAP3K140.65620206
63TEC0.62632994
64CAMK1D0.62559696
65EPHA40.60476601
66VRK10.57871702
67CSNK1A10.57654045
68SRPK10.55787133
69PINK10.55614489
70ITK0.54989975
71MAPK150.54491939
72IRAK10.53069556
73MAP3K110.52977280
74TRIM280.51394160
75FRK0.50363257
76CSNK1G20.49698972
77CSNK2A20.49171594
78CSNK2A10.48394866
79EPHB20.47406570
80MYLK0.47266317
81LRRK20.46991580
82CSNK1G30.46516422
83ABL20.46456164
84GRK50.46409803
85CSNK1A1L0.45752799
86ATM0.45177529
87FES0.45148754
88TESK10.44808093
89MAPK100.44209762
90ALK0.42412643
91MKNK10.41341594
92ILK0.40761733
93MARK10.37355056
94AURKB0.37039321
95STK40.35287481
96PASK0.35082251
97GSK3A0.34971800
98LMTK20.34846200
99PRKCE0.34231920
100PRKDC0.33546034

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.11724466
2Ribosome_Homo sapiens_hsa030103.68703928
3Oxidative phosphorylation_Homo sapiens_hsa001903.55303737
4Protein export_Homo sapiens_hsa030603.05982499
5Parkinsons disease_Homo sapiens_hsa050122.85224714
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.76497985
7RNA polymerase_Homo sapiens_hsa030202.51443363
8Homologous recombination_Homo sapiens_hsa034402.43102853
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.31647670
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.31468689
11Basal transcription factors_Homo sapiens_hsa030222.29206212
12Nucleotide excision repair_Homo sapiens_hsa034202.22085555
13N-Glycan biosynthesis_Homo sapiens_hsa005102.11920282
14Huntingtons disease_Homo sapiens_hsa050162.05748789
15Spliceosome_Homo sapiens_hsa030401.98012168
16One carbon pool by folate_Homo sapiens_hsa006701.95082656
17Alzheimers disease_Homo sapiens_hsa050101.89086527
18Cardiac muscle contraction_Homo sapiens_hsa042601.79925425
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.76937040
20DNA replication_Homo sapiens_hsa030301.74160418
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.71897063
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68161834
23RNA degradation_Homo sapiens_hsa030181.61604906
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60272357
25RNA transport_Homo sapiens_hsa030131.49971122
26Mismatch repair_Homo sapiens_hsa034301.43673966
27Fanconi anemia pathway_Homo sapiens_hsa034601.41916381
28Pyrimidine metabolism_Homo sapiens_hsa002401.35304084
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33031585
30Steroid biosynthesis_Homo sapiens_hsa001001.28880267
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28408589
32Phototransduction_Homo sapiens_hsa047441.21919052
33Purine metabolism_Homo sapiens_hsa002301.21357847
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16827082
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14633480
36Base excision repair_Homo sapiens_hsa034101.11722036
37Sulfur metabolism_Homo sapiens_hsa009201.11023949
38Selenocompound metabolism_Homo sapiens_hsa004501.02652802
39Propanoate metabolism_Homo sapiens_hsa006400.98211929
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97659394
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97398266
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94293996
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92641709
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91040696
45Vitamin digestion and absorption_Homo sapiens_hsa049770.87554530
46Linoleic acid metabolism_Homo sapiens_hsa005910.86050446
47beta-Alanine metabolism_Homo sapiens_hsa004100.81352628
48Histidine metabolism_Homo sapiens_hsa003400.80643367
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79286296
50Primary immunodeficiency_Homo sapiens_hsa053400.75524643
51Tryptophan metabolism_Homo sapiens_hsa003800.75372638
52Pyruvate metabolism_Homo sapiens_hsa006200.74751514
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73237889
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72485699
55Metabolic pathways_Homo sapiens_hsa011000.70078833
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68894753
57Fructose and mannose metabolism_Homo sapiens_hsa000510.63920856
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63299381
59Olfactory transduction_Homo sapiens_hsa047400.63015356
60Ether lipid metabolism_Homo sapiens_hsa005650.62063161
61Antigen processing and presentation_Homo sapiens_hsa046120.61491576
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58531281
63Regulation of autophagy_Homo sapiens_hsa041400.54135131
64mRNA surveillance pathway_Homo sapiens_hsa030150.50748762
65Nicotine addiction_Homo sapiens_hsa050330.47410908
66ABC transporters_Homo sapiens_hsa020100.45142999
67Rheumatoid arthritis_Homo sapiens_hsa053230.45098040
68Caffeine metabolism_Homo sapiens_hsa002320.44694497
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43527002
70Epstein-Barr virus infection_Homo sapiens_hsa051690.41735068
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.41519054
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41026171
73Butanoate metabolism_Homo sapiens_hsa006500.39543643
74Nitrogen metabolism_Homo sapiens_hsa009100.36926118
75Collecting duct acid secretion_Homo sapiens_hsa049660.35969461
76Arachidonic acid metabolism_Homo sapiens_hsa005900.32388073
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32258907
78Allograft rejection_Homo sapiens_hsa053300.31680182
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.31286904
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31127537
81TGF-beta signaling pathway_Homo sapiens_hsa043500.30657988
82Tight junction_Homo sapiens_hsa045300.30477427
83Glutathione metabolism_Homo sapiens_hsa004800.30241700
84Retinol metabolism_Homo sapiens_hsa008300.28772495
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.28020342
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.27854936
87Mineral absorption_Homo sapiens_hsa049780.27670527
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27327163
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26987552
90Autoimmune thyroid disease_Homo sapiens_hsa053200.26433523
91Oocyte meiosis_Homo sapiens_hsa041140.26112486
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.26103276
93Systemic lupus erythematosus_Homo sapiens_hsa053220.24315654
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23037493
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22981591
96Glycerolipid metabolism_Homo sapiens_hsa005610.22024018
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21034901
98Chemical carcinogenesis_Homo sapiens_hsa052040.20425213
99Taste transduction_Homo sapiens_hsa047420.19743137
100Type I diabetes mellitus_Homo sapiens_hsa049400.18674177

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