ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	4.66276759
2	DNA deamination (GO:0045006)	4.63158157
3	pseudouridine synthesis (GO:0001522)	4.54456254
4	somatic hypermutation of immunoglobulin genes (GO:0016446)	4.48916810
5	somatic diversification of immune receptors via somatic mutation (GO:0002566)	4.48916810
6	IMP biosynthetic process (GO:0006188)	4.29038417
7	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.25017317
8	regulation of chronic inflammatory response (GO:0002676)	4.23308071
9	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.06712785
10	regulation of immunoglobulin secretion (GO:0051023)	4.06671799
11	chaperone-mediated protein transport (GO:0072321)	3.95920116
12	maturation of 5.8S rRNA (GO:0000460)	3.95167519
13	rRNA modification (GO:0000154)	3.82880711
14	behavioral response to nicotine (GO:0035095)	3.79262434
15	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.78168432
16	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.74482195
17	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.57395745
18	ATP synthesis coupled proton transport (GO:0015986)	3.57395745
19	peptidyl-histidine modification (GO:0018202)	3.56888471
20	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.53762007
21	IMP metabolic process (GO:0046040)	3.36924846
22	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.35791362
23	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.35119322
24	isotype switching (GO:0045190)	3.35119322
25	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.35119322
26	kinetochore assembly (GO:0051382)	3.34866897
27	tRNA modification (GO:0006400)	3.29582641
28	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.29385718
29	mismatch repair (GO:0006298)	3.26944563
30	somatic diversification of immunoglobulins (GO:0016445)	3.26350892
31	synapsis (GO:0007129)	3.23591214
32	DNA catabolic process, exonucleolytic (GO:0000738)	3.23485948
33	folic acid-containing compound biosynthetic process (GO:0009396)	3.21573238
34	tRNA processing (GO:0008033)	3.17088225
35	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.14387118
36	ribosome assembly (GO:0042255)	3.14168252
37	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.13382003
38	cullin deneddylation (GO:0010388)	3.13371239
39	regulation of mitotic spindle checkpoint (GO:1903504)	3.08169050
40	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.08169050
41	water-soluble vitamin biosynthetic process (GO:0042364)	3.07198406
42	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.06502098
43	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.06443815
44	regulation of cellular amino acid metabolic process (GO:0006521)	3.04589085
45	purine-containing compound salvage (GO:0043101)	3.03830372
46	rRNA methylation (GO:0031167)	3.02545939
47	regulation of regulatory T cell differentiation (GO:0045589)	3.02293351
48	negative regulation of DNA recombination (GO:0045910)	3.01926180
49	peptidyl-arginine omega-N-methylation (GO:0035247)	3.01779613
50	regulation of isotype switching to IgG isotypes (GO:0048302)	3.01675268
51	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.98914077
52	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.98914077
53	non-recombinational repair (GO:0000726)	2.98695146
54	double-strand break repair via nonhomologous end joining (GO:0006303)	2.98695146
55	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.96970257
56	termination of RNA polymerase III transcription (GO:0006386)	2.95697645
57	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.95697645
58	DNA double-strand break processing (GO:0000729)	2.94129110
59	GTP biosynthetic process (GO:0006183)	2.93179669
60	activated T cell proliferation (GO:0050798)	2.92563047
61	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.92015082
62	nucleobase biosynthetic process (GO:0046112)	2.91703921
63	negative regulation of ligase activity (GO:0051352)	2.90438118
64	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.90438118
65	purine nucleobase biosynthetic process (GO:0009113)	2.89914386
66	resolution of meiotic recombination intermediates (GO:0000712)	2.89902363
67	reciprocal DNA recombination (GO:0035825)	2.88934751
68	reciprocal meiotic recombination (GO:0007131)	2.88934751
69	protein deneddylation (GO:0000338)	2.87422961
70	regulation of helicase activity (GO:0051095)	2.87194446
71	inner mitochondrial membrane organization (GO:0007007)	2.87039995
72	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.86627784
73	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.86627784
74	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.86627784
75	CENP-A containing nucleosome assembly (GO:0034080)	2.85898863
76	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.85745125
77	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.85446857
78	positive regulation of isotype switching (GO:0045830)	2.84747262
79	positive regulation of humoral immune response (GO:0002922)	2.84002669
80	rRNA processing (GO:0006364)	2.82902522
81	RNA modification (GO:0009451)	2.81653932
82	GMP metabolic process (GO:0046037)	2.81315667
83	somatic diversification of immune receptors (GO:0002200)	2.80717008
84	ribosomal large subunit biogenesis (GO:0042273)	2.80513739
85	termination of RNA polymerase I transcription (GO:0006363)	2.80477836
86	piRNA metabolic process (GO:0034587)	2.78075160
87	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.77607712
88	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.77607712
89	intracellular protein transmembrane import (GO:0044743)	2.76057678
90	DNA replication-dependent nucleosome organization (GO:0034723)	2.75987227
91	DNA replication-dependent nucleosome assembly (GO:0006335)	2.75987227
92	tRNA metabolic process (GO:0006399)	2.75930180
93	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.75676458
94	rRNA metabolic process (GO:0016072)	2.75263804
95	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.75122312
96	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.75122312
97	spliceosomal snRNP assembly (GO:0000387)	2.74820224
98	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.74781158
99	7-methylguanosine mRNA capping (GO:0006370)	2.73851384
100	chromatin remodeling at centromere (GO:0031055)	2.73207319

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.41983806
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.03983090
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.99316489
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.49519514
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.35161419
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.33263383
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.18781712
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.06195698
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.00547964
10	E2F7_22180533_ChIP-Seq_HELA_Human	2.73181451
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.66541683
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.66476098
13	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.63885206
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.57562501
15	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.47135655
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.44754318
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.43267110
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.42944013
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.38313986
20	ZNF274_21170338_ChIP-Seq_K562_Hela	2.34121398
21	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.31953300
22	FOXP3_21729870_ChIP-Seq_TREG_Human	2.28284893
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.26119928
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.99219525
25	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.99128638
26	IGF1R_20145208_ChIP-Seq_DFB_Human	1.89257695
27	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.88409885
28	EWS_26573619_Chip-Seq_HEK293_Human	1.86530897
29	VDR_22108803_ChIP-Seq_LS180_Human	1.83117396
30	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77557650
31	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.71647203
32	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.71592407
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.70820910
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.70404019
35	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.69302036
36	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.67382234
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.66398256
38	DCP1A_22483619_ChIP-Seq_HELA_Human	1.65564527
39	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.64026081
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.63305958
41	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.61436399
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.61121124
43	TAF15_26573619_Chip-Seq_HEK293_Human	1.50843016
44	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.50265101
45	GABP_19822575_ChIP-Seq_HepG2_Human	1.46784024
46	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.40131734
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.39914728
48	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.36796204
49	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.35205648
50	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.28109711
51	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.27561176
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.24854809
53	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.24417321
54	TTF2_22483619_ChIP-Seq_HELA_Human	1.23348855
55	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.22628404
56	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.20533967
57	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.19643727
58	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.19285699
59	FUS_26573619_Chip-Seq_HEK293_Human	1.18776438
60	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.17710556
61	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.17307491
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15866169
63	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.14130509
64	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.12562526
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12108886
66	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10457024
67	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10457024
68	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.10310607
69	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.09074276
70	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06505265
71	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.06315603
72	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.03694688
73	GATA3_26560356_Chip-Seq_TH2_Human	1.03159645
74	GBX2_23144817_ChIP-Seq_PC3_Human	1.02829594
75	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.01241886
76	AR_20517297_ChIP-Seq_VCAP_Human	1.00671895
77	P300_19829295_ChIP-Seq_ESCs_Human	1.00547644
78	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.99609497
79	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.98646137
80	TCF4_22108803_ChIP-Seq_LS180_Human	0.97887765
81	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.96638279
82	CBP_20019798_ChIP-Seq_JUKART_Human	0.96638279
83	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.96149264
84	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.95957061
85	SOX2_19829295_ChIP-Seq_ESCs_Human	0.95157930
86	NANOG_19829295_ChIP-Seq_ESCs_Human	0.95157930
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94954338
88	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.90469778
89	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.90358236
90	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.89641848
91	XRN2_22483619_ChIP-Seq_HELA_Human	0.88359312
92	EZH2_22144423_ChIP-Seq_EOC_Human	0.88033239
93	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.85937911
94	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.85473092
95	NCOR_22424771_ChIP-Seq_293T_Human	0.84173671
96	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.83935080
97	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.83183245
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.81867957
99	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.80408801
100	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.80161796

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.03926486
2	MP0008058_abnormal_DNA_repair	3.62900936
3	MP0003718_maternal_effect	3.43085413
4	MP0010094_abnormal_chromosome_stability	2.93594607
5	MP0003693_abnormal_embryo_hatching	2.54992762
6	MP0008872_abnormal_physiological_respon	2.47696301
7	MP0006072_abnormal_retinal_apoptosis	2.42893030
8	MP0003111_abnormal_nucleus_morphology	2.41823137
9	MP0004957_abnormal_blastocyst_morpholog	2.34181666
10	MP0004147_increased_porphyrin_level	2.26176168
11	MP0003195_calcinosis	2.17716230
12	MP0008057_abnormal_DNA_replication	2.16159530
13	MP0003786_premature_aging	2.11183027
14	MP0003787_abnormal_imprinting	2.10153689
15	MP0006292_abnormal_olfactory_placode	2.07200070
16	MP0003077_abnormal_cell_cycle	2.06648399
17	MP0005551_abnormal_eye_electrophysiolog	2.04647938
18	MP0002736_abnormal_nociception_after	2.04055031
19	MP0001348_abnormal_lacrimal_gland	1.98375262
20	MP0003011_delayed_dark_adaptation	1.92312083
21	MP0001986_abnormal_taste_sensitivity	1.86712323
22	MP0001835_abnormal_antigen_presentation	1.81296137
23	MP0005671_abnormal_response_to	1.79286930
24	MP0001984_abnormal_olfaction	1.68393731
25	MP0002160_abnormal_reproductive_system	1.67677326
26	MP0005253_abnormal_eye_physiology	1.66080134
27	MP0006035_abnormal_mitochondrial_morpho	1.63196963
28	MP0005389_reproductive_system_phenotype	1.62646337
29	MP0000427_abnormal_hair_cycle	1.61842633
30	MP0000569_abnormal_digit_pigmentation	1.61786170
31	MP0008875_abnormal_xenobiotic_pharmacok	1.59285808
32	MP0003950_abnormal_plasma_membrane	1.54216053
33	MP0005167_abnormal_blood-brain_barrier	1.52757567
34	MP0001919_abnormal_reproductive_system	1.49891604
35	MP0002254_reproductive_system_inflammat	1.41256227
36	MP0008995_early_reproductive_senescence	1.41061366
37	MP0001968_abnormal_touch/_nociception	1.41007886
38	MP0002090_abnormal_vision	1.38807715
39	MP0002210_abnormal_sex_determination	1.37571368
40	MP0002102_abnormal_ear_morphology	1.37293744
41	MP0001929_abnormal_gametogenesis	1.37041782
42	MP0002938_white_spotting	1.27825688
43	MP0001501_abnormal_sleep_pattern	1.27019770
44	MP0005395_other_phenotype	1.26264556
45	MP0006036_abnormal_mitochondrial_physio	1.25696367
46	MP0004885_abnormal_endolymph	1.21804887
47	MP0000372_irregular_coat_pigmentation	1.16800011
48	MP0005645_abnormal_hypothalamus_physiol	1.15909643
49	MP0005646_abnormal_pituitary_gland	1.13861948
50	MP0002837_dystrophic_cardiac_calcinosis	1.12313555
51	MP0000685_abnormal_immune_system	1.10560669
52	MP0001502_abnormal_circadian_rhythm	1.09991533
53	MP0001873_stomach_inflammation	1.09503175
54	MP0009785_altered_susceptibility_to	1.07524197
55	MP0005379_endocrine/exocrine_gland_phen	1.07113864
56	MP0001119_abnormal_female_reproductive	1.05038719
57	MP0000653_abnormal_sex_gland	1.04899455
58	MP0002163_abnormal_gland_morphology	1.01508634
59	MP0003763_abnormal_thymus_physiology	1.01495450
60	MP0001293_anophthalmia	1.00555456
61	MP0005084_abnormal_gallbladder_morpholo	1.00331607
62	MP0002876_abnormal_thyroid_physiology	0.99074009
63	MP0002148_abnormal_hypersensitivity_rea	0.98918954
64	MP0008932_abnormal_embryonic_tissue	0.98711370
65	MP0002751_abnormal_autonomic_nervous	0.98058955
66	MP0001145_abnormal_male_reproductive	0.96341866
67	MP0002006_tumorigenesis	0.96210379
68	MP0003186_abnormal_redox_activity	0.90507346
69	MP0002653_abnormal_ependyma_morphology	0.89921381
70	MP0005085_abnormal_gallbladder_physiolo	0.89217833
71	MP0003121_genomic_imprinting	0.87151860
72	MP0008775_abnormal_heart_ventricle	0.85832040
73	MP0005410_abnormal_fertilization	0.85424302
74	MP0009745_abnormal_behavioral_response	0.85388522
75	MP0005310_abnormal_salivary_gland	0.85214079
76	MP0002272_abnormal_nervous_system	0.83684954
77	MP0001486_abnormal_startle_reflex	0.83635517
78	MP0008789_abnormal_olfactory_epithelium	0.83181419
79	MP0003698_abnormal_male_reproductive	0.83177927
80	MP0005647_abnormal_sex_gland	0.80729962
81	MP0002234_abnormal_pharynx_morphology	0.80504944
82	MP0009697_abnormal_copulation	0.79420690
83	MP0001853_heart_inflammation	0.79042435
84	MP0002638_abnormal_pupillary_reflex	0.78754576
85	MP0003866_abnormal_defecation	0.78524502
86	MP0003806_abnormal_nucleotide_metabolis	0.78515512
87	MP0003567_abnormal_fetal_cardiomyocyte	0.77619099
88	MP0003436_decreased_susceptibility_to	0.76448325
89	MP0009764_decreased_sensitivity_to	0.75004325
90	MP0004145_abnormal_muscle_electrophysio	0.74866659
91	MP0008007_abnormal_cellular_replicative	0.73947415
92	MP0001800_abnormal_humoral_immune	0.72382457
93	MP0009333_abnormal_splenocyte_physiolog	0.72244210
94	MP0002405_respiratory_system_inflammati	0.70498073
95	MP0004142_abnormal_muscle_tone	0.69513882
96	MP0008770_decreased_survivor_rate	0.68465562
97	MP0001346_abnormal_lacrimal_gland	0.67785387
98	MP0002139_abnormal_hepatobiliary_system	0.64992951
99	MP0003699_abnormal_female_reproductive	0.64757840
100	MP0000689_abnormal_spleen_morphology	0.63507335

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	3.94736286
2	3-Methylglutaconic aciduria (HP:0003535)	3.76252237
3	Renal cortical cysts (HP:0000803)	3.55443670
4	Increased CSF lactate (HP:0002490)	3.24664995
5	Acute necrotizing encephalopathy (HP:0006965)	3.23188321
6	Increased hepatocellular lipid droplets (HP:0006565)	3.19320780
7	Colon cancer (HP:0003003)	3.19070057
8	Type 2 muscle fiber atrophy (HP:0003554)	3.11992103
9	Lipid accumulation in hepatocytes (HP:0006561)	3.07838304
10	Nephronophthisis (HP:0000090)	3.07662343
11	Acute encephalopathy (HP:0006846)	3.06984658
12	Methylmalonic acidemia (HP:0002912)	3.05984066
13	Decreased central vision (HP:0007663)	3.01944499
14	Pancreatic cysts (HP:0001737)	2.98899721
15	Mitochondrial inheritance (HP:0001427)	2.96885122
16	Abnormality of the renal cortex (HP:0011035)	2.82463580
17	IgG deficiency (HP:0004315)	2.80612627
18	Abnormal mitochondria in muscle tissue (HP:0008316)	2.76516995
19	Testicular atrophy (HP:0000029)	2.74116082
20	Progressive macrocephaly (HP:0004481)	2.73350110
21	Ependymoma (HP:0002888)	2.68414751
22	Visual hallucinations (HP:0002367)	2.65245340
23	Prostate neoplasm (HP:0100787)	2.62853739
24	Muscle fiber atrophy (HP:0100295)	2.62250523
25	Congenital stationary night blindness (HP:0007642)	2.60721164
26	Autoimmune thrombocytopenia (HP:0001973)	2.59508484
27	Increased serum lactate (HP:0002151)	2.55873126
28	Abnormality of the pons (HP:0007361)	2.54397732
29	Focal motor seizures (HP:0011153)	2.53535850
30	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.49667752
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.49659711
32	Abnormality of alanine metabolism (HP:0010916)	2.48073853
33	Hyperalaninemia (HP:0003348)	2.48073853
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.48073853
35	Molar tooth sign on MRI (HP:0002419)	2.47440477
36	Abnormality of midbrain morphology (HP:0002418)	2.47440477
37	Pancreatic fibrosis (HP:0100732)	2.42661228
38	Abnormality of the renal medulla (HP:0100957)	2.39748828
39	Pendular nystagmus (HP:0012043)	2.36233016
40	Type II lissencephaly (HP:0007260)	2.31672765
41	True hermaphroditism (HP:0010459)	2.31354398
42	Stomatitis (HP:0010280)	2.30767954
43	Methylmalonic aciduria (HP:0012120)	2.30684485
44	Degeneration of anterior horn cells (HP:0002398)	2.30360922
45	Abnormality of the anterior horn cell (HP:0006802)	2.30360922
46	Aplasia/hypoplasia of the uterus (HP:0008684)	2.29552948
47	Opisthotonus (HP:0002179)	2.25996593
48	Duplicated collecting system (HP:0000081)	2.23486650
49	Hepatic necrosis (HP:0002605)	2.22656667
50	Glioma (HP:0009733)	2.21977602
51	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.20568037
52	Cerebral edema (HP:0002181)	2.15231187
53	Lactic acidosis (HP:0003128)	2.14597943
54	Supernumerary spleens (HP:0009799)	2.13648739
55	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.13225555
56	Hypoplasia of the uterus (HP:0000013)	2.11756368
57	Severe combined immunodeficiency (HP:0004430)	2.09430233
58	Hypoplasia of the pons (HP:0012110)	2.08765738
59	Hepatocellular necrosis (HP:0001404)	2.08197877
60	Renal Fanconi syndrome (HP:0001994)	2.07470609
61	Meckel diverticulum (HP:0002245)	2.07424695
62	Abnormality of the ileum (HP:0001549)	2.06481722
63	Progressive inability to walk (HP:0002505)	2.05903480
64	Optic disc pallor (HP:0000543)	2.05867013
65	Attenuation of retinal blood vessels (HP:0007843)	2.03526677
66	Abnormality of serum amino acid levels (HP:0003112)	2.03477989
67	Abnormality of the renal collecting system (HP:0004742)	2.01975358
68	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.00774241
69	Abnormality of T cell physiology (HP:0011840)	1.99538553
70	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.98067869
71	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.98067869
72	Oral leukoplakia (HP:0002745)	1.98066796
73	Lethargy (HP:0001254)	1.97988398
74	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.96239954
75	Asplenia (HP:0001746)	1.94871505
76	Increased serum pyruvate (HP:0003542)	1.94762322
77	Abnormality of vitamin B metabolism (HP:0004340)	1.93436532
78	Parakeratosis (HP:0001036)	1.92771275
79	Exertional dyspnea (HP:0002875)	1.92447517
80	Agnosia (HP:0010524)	1.91402218
81	Congenital, generalized hypertrichosis (HP:0004540)	1.91152619
82	Thyroiditis (HP:0100646)	1.91051942
83	Abnormality of B cell number (HP:0010975)	1.90479914
84	Fibular aplasia (HP:0002990)	1.90240622
85	Autoimmune hemolytic anemia (HP:0001890)	1.89688423
86	Short tibia (HP:0005736)	1.85125465
87	Abolished electroretinogram (ERG) (HP:0000550)	1.84830965
88	Abnormality of the astrocytes (HP:0100707)	1.84605190
89	Astrocytoma (HP:0009592)	1.84605190
90	B lymphocytopenia (HP:0010976)	1.84244110
91	Hypoplasia of the fovea (HP:0007750)	1.82154991
92	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.82154991
93	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.79427424
94	Pancytopenia (HP:0001876)	1.78692610
95	Exercise intolerance (HP:0003546)	1.78390747
96	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.78067284
97	Lissencephaly (HP:0001339)	1.77239863
98	Rhabdomyosarcoma (HP:0002859)	1.77181083
99	Abnormal spermatogenesis (HP:0008669)	1.75616062
100	Abnormality of the fovea (HP:0000493)	1.73792463

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	5.77016013
2	TSSK6	4.06619181
3	ZAK	3.84437251
4	NEK1	3.47238952
5	BUB1	3.31149372
6	EIF2AK1	2.98104621
7	TLK1	2.69948595
8	PBK	2.67771163
9	VRK2	2.67499886
10	EIF2AK3	2.58255296
11	SRPK1	2.15067863
12	VRK1	2.00849610
13	NUAK1	2.00234155
14	PLK3	1.91615502
15	STK16	1.89828402
16	MST4	1.86121600
17	ADRBK2	1.84800085
18	TXK	1.79701111
19	CDC7	1.73565331
20	MKNK1	1.54746433
21	FRK	1.54317608
22	BMPR1B	1.44768966
23	WNK3	1.43300898
24	TRIM28	1.35816588
25	STK4	1.35352357
26	BCKDK	1.30689484
27	GRK1	1.26123744
28	TAOK3	1.23616524
29	CSNK1G3	1.17210402
30	CSNK1A1L	1.14220315
31	DYRK2	1.07620961
32	EIF2AK2	1.07548718
33	MKNK2	1.03707732
34	CSNK1G1	1.02068571
35	TTK	1.00718506
36	PLK4	1.00622983
37	PLK1	0.94141350
38	CSNK1G2	0.91011576
39	WNK4	0.89665484
40	ATR	0.88877320
41	WEE1	0.87006980
42	MAP3K4	0.84713207
43	AURKB	0.84497186
44	PHKG2	0.83836892
45	PHKG1	0.83836892
46	PDK2	0.82326233
47	BMPR2	0.79627785
48	MAP4K1	0.78249454
49	ALK	0.77997067
50	PASK	0.77971324
51	CDK19	0.75612892
52	ATM	0.69162059
53	OXSR1	0.67612288
54	TAF1	0.66181781
55	DYRK3	0.65033843
56	CHEK2	0.63709351
57	NME2	0.63238120
58	TIE1	0.63179310
59	IKBKB	0.62356564
60	FES	0.60635556
61	PNCK	0.60157481
62	STK3	0.59155611
63	MAPK13	0.56914031
64	INSRR	0.55596934
65	CSNK1A1	0.49113914
66	CSNK2A1	0.49105282
67	AURKA	0.49104423
68	NME1	0.49065109
69	TEC	0.48579460
70	CSNK2A2	0.47767474
71	CAMKK2	0.47165742
72	MAP2K7	0.44609923
73	RPS6KA5	0.44464743
74	DAPK1	0.43145973
75	CSNK1E	0.42535923
76	CHEK1	0.40778242
77	BRSK2	0.38865518
78	CAMK2A	0.38383220
79	EPHA4	0.38356819
80	MAP2K6	0.36157149
81	BCR	0.35444791
82	MARK1	0.34694554
83	PAK4	0.33219982
84	TNIK	0.29563685
85	PAK3	0.29558730
86	PINK1	0.29386575
87	MET	0.26185470
88	PLK2	0.25834153
89	PRKCQ	0.25462721
90	GRK5	0.24086409
91	AKT3	0.23913844
92	PRKDC	0.23218395
93	CSNK1D	0.23150282
94	PRKACA	0.22127387
95	GRK6	0.21666682
96	IGF1R	0.21658240
97	PRKCA	0.20750315
98	CAMK2D	0.20735844
99	ERBB3	0.20446987
100	PRKCG	0.20203816

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.11412153
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.22761227
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.02277423
4	RNA polymerase_Homo sapiens_hsa03020	2.95224575
5	Homologous recombination_Homo sapiens_hsa03440	2.92397997
6	Mismatch repair_Homo sapiens_hsa03430	2.85992114
7	One carbon pool by folate_Homo sapiens_hsa00670	2.58561237
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.51003201
9	Basal transcription factors_Homo sapiens_hsa03022	2.32961642
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.22393559
11	RNA degradation_Homo sapiens_hsa03018	2.10203597
12	Spliceosome_Homo sapiens_hsa03040	2.09114990
13	Protein export_Homo sapiens_hsa03060	2.05576712
14	DNA replication_Homo sapiens_hsa03030	1.99977234
15	Parkinsons disease_Homo sapiens_hsa05012	1.97460498
16	Base excision repair_Homo sapiens_hsa03410	1.97259974
17	RNA transport_Homo sapiens_hsa03013	1.83670193
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.76420579
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.73541337
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.72232726
21	Phototransduction_Homo sapiens_hsa04744	1.61849335
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.60721488
23	Purine metabolism_Homo sapiens_hsa00230	1.57554549
24	Caffeine metabolism_Homo sapiens_hsa00232	1.57447660
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.53718978
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.53543375
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.52572669
28	Primary immunodeficiency_Homo sapiens_hsa05340	1.51068254
29	Ribosome_Homo sapiens_hsa03010	1.42848964
30	Propanoate metabolism_Homo sapiens_hsa00640	1.41829639
31	Huntingtons disease_Homo sapiens_hsa05016	1.39994851
32	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.39034613
33	Butanoate metabolism_Homo sapiens_hsa00650	1.33892942
34	Asthma_Homo sapiens_hsa05310	1.33336801
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.31119659
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.30706268
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.30249238
38	Steroid biosynthesis_Homo sapiens_hsa00100	1.24831935
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.21490201
40	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.15885398
41	Allograft rejection_Homo sapiens_hsa05330	1.12191293
42	Sulfur metabolism_Homo sapiens_hsa00920	1.08896618
43	Alzheimers disease_Homo sapiens_hsa05010	1.05102411
44	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.04641232
45	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.00958119
46	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.00726117
47	Linoleic acid metabolism_Homo sapiens_hsa00591	0.98531493
48	Peroxisome_Homo sapiens_hsa04146	0.95070871
49	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.85244697
50	Fatty acid elongation_Homo sapiens_hsa00062	0.85089207
51	Type I diabetes mellitus_Homo sapiens_hsa04940	0.84134982
52	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.76559606
53	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.76205837
54	Selenocompound metabolism_Homo sapiens_hsa00450	0.76066466
55	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.73446317
56	Cell cycle_Homo sapiens_hsa04110	0.72871861
57	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.70778233
58	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.69616136
59	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.69583339
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.68295284
61	Metabolic pathways_Homo sapiens_hsa01100	0.66479812
62	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.66100973
63	mRNA surveillance pathway_Homo sapiens_hsa03015	0.65251996
64	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.64923606
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.64853476
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.64415229
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.61327322
68	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.59327827
69	Olfactory transduction_Homo sapiens_hsa04740	0.58152603
70	Glutathione metabolism_Homo sapiens_hsa00480	0.54588601
71	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.52185939
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.48576199
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.48298921
74	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.45049913
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42969194
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.42318783
77	Retinol metabolism_Homo sapiens_hsa00830	0.41796408
78	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41013801
79	Alcoholism_Homo sapiens_hsa05034	0.40986518
80	Oocyte meiosis_Homo sapiens_hsa04114	0.38000488
81	Graft-versus-host disease_Homo sapiens_hsa05332	0.37097732
82	Cardiac muscle contraction_Homo sapiens_hsa04260	0.36670136
83	Pyruvate metabolism_Homo sapiens_hsa00620	0.36161133
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33839023
85	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.33543597
86	Circadian rhythm_Homo sapiens_hsa04710	0.33071314
87	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32963729
88	p53 signaling pathway_Homo sapiens_hsa04115	0.32023820
89	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.31472670
90	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.30724434
91	Nitrogen metabolism_Homo sapiens_hsa00910	0.30512327
92	Carbon metabolism_Homo sapiens_hsa01200	0.30368069
93	Folate biosynthesis_Homo sapiens_hsa00790	0.27643770
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.27589864
95	Taste transduction_Homo sapiens_hsa04742	0.26757481
96	Antigen processing and presentation_Homo sapiens_hsa04612	0.26508170
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.26439987
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.25615566
99	Chemical carcinogenesis_Homo sapiens_hsa05204	0.25354030
100	Mineral absorption_Homo sapiens_hsa04978	0.25329931

HNRNPA1P47

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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